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ASPERGILLOSIS and MUCORMYCOSIS 27 - 29 February 2020 Lugano, Switzerland APPLICATIONS OPENING SOON ABSTRACT BOOK 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 Lugano, Switzerland www.AAAM2020.org APPLICATIONS OPENING SOON The Gilead Sciences International Research Scholars Program in Anti-fungals is to support innovative scientific research to advance knowledge in the field of anti-fungals and improve the lives of patients everywhere Each award will be funded up to USD $130K, to be paid in annual installments up to USD $65K Awards are subject to separate terms and conditions A scientific review committee of internationally recognized experts in the field of fungal infection will review all applications Applications will be accepted by residents of Europe, Middle East, Australia, Asia (Singapore, Hong Kong, Taiwan, South Korea) and Latin America (Mexico, Brazil, Argentina and Colombia) For complete program information and to submit an application, please visit the website: http://researchscholars.gilead.com © 2020 Gilead Sciences, Inc. All rights reserved. IHQ-ANF-2020-01-0007 GILEAD and the GILEAD logo are trademarks of Gilead Sciences, Inc. 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS Lugano, Switzerland 27 - 29 February 2020 Palazzo dei Congressi Lugano www.AAAM2020.org 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland Dear Advances Against Aspergillosis and Mucormycosis Colleague, This 9th Advances Against Aspergillosis and Mucormycosis conference continues to grow and change with the field. The previous eight meetings were overwhelmingly successful, including the first meeting in 2004 (San Francisco) where we had 364 attendees from 28 countries, the second meeting in 2006 (Athens) with 464 attendees from 44 countries, the third meeting in 2008 (Miami) with 351 attendees from 48 countries, the fourth meeting in 2010 (Rome) with 533 attendees from 41 countries, the fifth meeting in 2012 (Istanbul) with 375 attendees from 39 countries, the sixth meeting in 2014 (Madrid) with 342 attendees from 33 countries, the seventh meeting in 2016 (Manchester) with 363 attendees from 38 countries, and the eighth meeting in 2018 (Lisbon) with 334 attendees from 38 countries and the first meeting where we added molecular and clinical mucormycosis research. When our 2020 meeting convenes, it will represent the 18th year of Advances Against Aspergillosis activity, beginning with the initial supplement in Clinical Infectious Diseases. Because of all of you, this conference has now established itself as the premier forum for discussion of all aspects of Aspergillus and now mucormycosis infection and research. The Aspergillus field continues in a state of rapid advancement, including the publication of numerous post- genomic papers and substantial advances in translational, immunologic, and diagnostic research. We have seen the launch of another effective antifungal for invasive aspergillosis (isavuconazole) and ongoing or anticipated clinical trials of numerous newer compounds is an exciting time for mycology. Itraconazole, pan- azole, and echinocandin resistance has emerged, and combination therapy and targeted immune exploration remains an important area of interest. Greatly increased awareness of allergic aspergillosis has opened new market opportunities for both antifungal agents and immunotherapies. There is a continuing high death toll from invasive aspergillosis, particularly among patient groups not usually associated with this opportunistic infection. This meeting is another chance to gather the world’s aspergillosis and mucormycosis experts in one venue. A fundamental tenet of this colloquium continues to be to engender collaborative relationships amongst clinicians, scientists, and industry to further advance the field. Because of the international success of the Advances Against Aspergillosis meetings in raising awareness of filamentous fungal infections, in 2018 we expanded our program to also provide a home and venue for presentations on the related science and devastating clinical entities of mucormycosis. Due to the success of that venture, the 2020 program also includes an exciting new session and many posters for that discipline. We thank the many corporate and foundation sponsors, listed in this program; without their support, this conference would not have been possible. We also thank the Scientific Committee, especially our Scientific Committee Chair Prof. Cornelia Lass-Flörl, for helping to assemble a truly international speaker list from the top centers in the world, with a focus on contemporary topics. By our design, much of the newest published literature and hypotheses in the field have originated from the speakers of this conference. In the program, we have introduced many speakers who did not speak at the previous Advances Against Aspergillosis meetings, including some young scientists and clinicians - a pattern we would like to repeat in future years. This year we have again increased the number of oral presentations from submitted abstracts to represent the wider community. We also thank all the speakers and poster presenters for contributing to the success of this effort. Please also join us at the welcome reception, the symposia, the tour and dinner, and the poster sessions. An essential part of this conference is the new friendships we expect will result, and the support of young 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland scientists entering the field. To engage younger scientists in our field, over 9 meetings we have offered a total of 269 scholarships to trainees, largely from less developed countries, where the conference paid for travel and hotel costs to attend the meeting. The proceedings of this 9th meeting will be published in Journal of Fungi, creating what we hope will be highlights of the newer insights from the many disciplines that encompass Aspergillus research and care. As Advances Against Aspergillosis has become the leading global meeting for basic and clinical science regarding Aspergillus, its efforts form one of the foundations of the repository of knowledge about this pathogen; 267 papers have been published in 9 Supplements, comprising 2,026 pages, as well as 1,429 abstracts from the meetings (not including this meeting). Our plan is to continue this conference every other year, and you will notice that there is a special open planning session for the next conference at the end of this meeting. We invite you to come and offer any suggestions for new sessions or topics or locations you would like to see in the future. Yours sincerely, David W. Denning David A. Stevens William J. Steinbach Co-Organizer Co-Organizer Co-Organizer [email protected] [email protected] [email protected] 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland ACKNOWLEDGEMENTS We would like to offer very special thanks to the following organizations for their generous educational grants. Their financial support makes this conference possible. Silver Bronze Others 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland TABLE OF CONTENTS Chairs, Scientific Committee ....................................................... 1 Faculty List ................................................................................... 3 Faculty Disclosures ...................................................................... 5 Poster Abstract Index .................................................................. 7 Scholarship Awards ..................................................................... 21 Final Programme Thursday 27 February ............................................................ 23 Friday 28 February ................................................................. 26 Saturday 29 February ............................................................. 28 Abstracts Invited Faculty ........................................................................ 31 Poster Abstracts ....................................................................... 63 Conference Sponsors ................................................................... 251 Author Index ................................................................................ 257 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland CONFERENCE CHAIRS AND SCIENTIFIC COMMITTEE Chairs David W. Denning, MBBS / University of Manchester, UK William J. Steinbach, MD / Duke University, USA David A. Stevens, MD / Stanford University, USA Scientific Committee Elaine Bignell, PhD / University of Manchester, UK Oliver Cornely, MD / University of Cologne, Germany David B. Corry, MD / Baylor College of Medicine, USA Hubertus Haas, PhD / Medical University of Innsbruck, Austria Nina Khanna, MD / University Hospital of Basel, Switzerland Frederic Lamoth, MD / Lausanne University Hospital, Switzerland Cornelia Lass-Florl, MD PhD / Innsbruck Medical University, Austria Yoshitsugu Miyazaki, MD PhD / National Institute of Infectious Diseases, Japan Richard B. Moss, MD / Stanford University, USA Teresa Zelante, PhD / University of Perugia, Italy Li-Ping Zhu, MD PhD / Huashan Hospital, Fudan University, China - 1 - - 2 - 9th ADVANCES AGAINST ASPERGILLOSIS AND MUCORMYCOSIS 27 - 29 February 2020 - Lugano, Switzerland FACULTY David R. Andes, MD Kirk M. Druey, MD University of Wisconsin, USA National Institute of Allergy and Infectious Diseases/National Institutes of Health, USA Petra Bacher, PhD University
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