International Journal of Molecular Sciences Review Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis 1, 1, 1,2, 1 Ettore Dolcetti y, Antonio Bruno y , Livia Guadalupi y, Francesca Romana Rizzo , Alessandra Musella 2,3, Antonietta Gentile 2, Francesca De Vito 4, Silvia Caioli 4, Silvia Bullitta 1,2, Diego Fresegna 2, Valentina Vanni 1,2, Sara Balletta 1, Krizia Sanna 1, Fabio Buttari 4, Mario Stampanoni Bassi 4 , Diego Centonze 1,4,* and Georgia Mandolesi 2,3 1 Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy;
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[email protected] (G.M.) 3 Department of Human Sciences and Quality of Life Promotion, University of Rome San Raffaele, 00163 Rome, Italy 4 Unit of Neurology, IRCCS Neuromed, Pozzilli (Is), 86077 Pozzilli, Italy;
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[email protected]; Tel.:+39-06 7259-6010; Fax: +39-06-7259-6006 Co-first authors. y Received: 30 August 2020; Accepted: 1 October 2020; Published: 4 October 2020 Abstract: Extracellular vesicles (EVs) represent a new reality for many physiological and pathological functions as an alternative mode of intercellular communication.