Tests Performed So Far to Try to Identify the Cause of CRGV

Tests performed so far to try to identify the cause of CRGV

• The urine of affected dogs has been tested for the following toxins:

Antiarrhythmics Antihistamines Doxapram Toxins Disopyramide Diphenhydramine Theophylline Alpha chloralose* screen Verapamil Chlorpheniramine Theobromine* Paraquat Cyclizine Propranolol Diquat Analgesics Reserpine Strychnine Dextropropoxyphene NSAIDS* Metaldehyde Phenothiazines Tramadol Acetylsalicylic acid* Methiocarb Pethidine Phenylbutazone Acepromazine Flunixin Chlorpromazine Separate single agents Anticonvulsants Meclofenamic acid Thioridazine not in panel Triﬂuoperazine Carbamazepine Diclofenac Ethylene glycol Promazine Phenobarbitone Ibubrofen Organophosphates/Carbamates Flurbiprofen Promethazine Coumarin derivatives Fluphenazine Antidepressants Diﬂunisal Carbon monoxide Indomethacin Cannabis Amitriptyline Tolmetin Drugs of Abuse Ricinine Imipramine Oxyphenylbutazone Desipramine Morphine* Pirioxicam (feldene) Barbiturates Trimipramine Methadone Naproxen Clomipramine Cocaine* Amylobarbitone Paracetamol Dothiepin Phencyclidine Secobarbitone Citalopram Ketamine Butobarbitone Miscellaneous Sertaline Pentobarbitone Hypnotics Fluoxetine Caffeine Diazepam Chocolate (Theobromine) Zopiclone Nicotine/Cotinine Xylazine

• Kidney tissue has been tested for heavy metals • Tissues have been tested for viral genetic material • Faeces, urine and skin lesions have been cultured to check for bacteria • Tissues have been tested for bacterial genetic material • Tissues and faeces have been tested for E.coli genetic material and shiga toxin • Dogs have been tested for Lyme’s disease and for Leptospirosis (Weil’s disease) via a number of different tests • Environmental testing for heavy metals, bacteria and semi-volatile toxic organic pollutants has been performed • A forensic botanist has been consulted and has performed a site visit regarding the possibility of plants (trees, shrubs, grasses, fungi) causing CRGV • Arachnologists have been consulted regarding possible venomous spiders causing CRGV So far all of these tests have been negative for identifying the cause of CRGV.