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LC-MS in Drug Analysis Methods and Protocols Second Edition M ETHODS in M OLECULAR B IOLOGY
Methods in Molecular Biology 1872 Loralie J. Langman Christine L.H. Snozek Editors LC-MS in Drug Analysis Methods and Protocols Second Edition M ETHODS IN M OLECULAR B IOLOGY Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK For further volumes: http://www.springer.com/series/7651 LC-MS in Drug Analysis Methods and Protocols Second Edition Edited by Loralie J. Langman Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA Christine L.H. Snozek Department of Laboratory Medicine and Pathology, Mayo Clinic in Arizona, Scottsdale, AZ, USA Editors Loralie J. Langman Christine L.H. Snozek Department of Laboratory Department of Laboratory Medicine and Pathology Medicine and Pathology Mayo Clinic Mayo Clinic in Arizona Rochester, MN, USA Scottsdale, AZ, USA ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8822-8 ISBN 978-1-4939-8823-5 (eBook) https://doi.org/10.1007/978-1-4939-8823-5 Library of Congress Control Number: 2018957456 © Springer Science+Business Media, LLC, part of Springer Nature 2012, 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. -
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( 12 ) United States Patent
US010166199B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 166 , 199 B2 Jones et al. ( 45 ) Date of Patent : Jan . 1 , 2019 ( 54 ) TRANSDERMAL PATCH COMPRISING A (58 ) Field of Classification Search ROPIVACAINE FORMULATION None (71 ) Applicant: BUZZZ PHARMACEUTICALS See application file for complete search history . LIMITED , Raheny , Dublin ( IE ) ( 56 ) References Cited ( 72 ) Inventors : Chris Jones , Cardiff GB( ) ; Darren U . S . PATENT DOCUMENTS Green , Cardiff (GB ) 4 , 956 , 171 A * 9 / 1990 Chang .. A61K 9 / 0014 ( 73 ) Assignee : Buzzz Pharmaceuticals Limited , 424 /448 Dublin (IE ) 9 , 295, 655 B2 * 3 / 2016 Choi .. .. .. .. .. .. A61K 9 / 7053 (Continued ) ( * ) Notice : Subject to any disclaimer , the term of this patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U . S . C . 154 ( b ) by 0 days . EP 1661560 5 /2006 (21 ) Appl. No. : 15 /027 , 905 EP 1964552 9 / 2008 ( Continued ) ( 22 ) PCT Filed : Oct . 7 , 2014 ( 86 ) PCT No .: PCT/ EP2014 /071437 OTHER PUBLICATIONS $ 371 ( c ) ( 1 ) , Merriam Webster definition of oil ( obtained online May 25, 2017 ). * ( 2 ) Date : Apr. 7 , 2016 (Continued ) ( 87 ) PCT Pub . No . : W02015 / 052183 Primary Examiner — Robert A Wax PCT Pub. Date : Apr. 16 , 2015 Assistant Examiner — Melissa S Mercier (74 ) Attorney , Agent, or Firm - Barnes & Thornburg , (65 ) Prior Publication Data LLP US 2016 / 0235689 A1 Aug. 18 , 2016 (57 ) ABSTRACT (30 ) Foreign Application Priority Data The present invention relates to a transdermal patch com prising a pharmaceutical formulation , the formulation com Oct . 7 , 2013 ( EP ) .. .. .. .. .. .. .. .. .. .. .. 1317718 prising ropivacaine or an opioid , a pharmaceutically - accept able adhesive and optionally one or more excipients selected (51 ) Int. -
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Ancient Spartan War Tactics
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ILLICIT DRUGS in the ENVIRONMENT Occurrence, Analysis, and Fate Using Mass Spectrometry
P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come ILLICIT DRUGS IN THE ENVIRONMENT Occurrence, Analysis, and Fate Using Mass Spectrometry Edited by SARA CASTIGLIONI ETTORE ZUCCATO ROBERTO FANELLI Department of Environmental Health Sciences Mario Negri Institute for Pharmacological Research Milan, Italy A JOHN WILEY & SONS, INC., PUBLICATION iii P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come ILLICIT DRUGS IN THE ENVIRONMENT i P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come WILEY-INTERSCIENCE SERIES IN MASS SPECTROMETRY Series Editors Dominic M. Desiderio Departments of Neurology and Biochemistry University of Tennessee Health Science Center Nico M. M. Nibbering Vrije Universiteit Amsterdam, The Netherlands A complete list of the titles in this series appears at the end of this volume. ii P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come ILLICIT DRUGS IN THE ENVIRONMENT Occurrence, Analysis, and Fate Using Mass Spectrometry Edited by SARA CASTIGLIONI ETTORE ZUCCATO ROBERTO FANELLI Department of Environmental Health Sciences Mario Negri Institute for Pharmacological Research Milan, Italy A JOHN WILEY & SONS, INC., PUBLICATION iii P1: OSO FM JWBS057-Castiglioni January 5, 2011 13:58 Printer Name: Yet to Come Copyright C 2011 by John Wiley & Sons, Inc. All rights reserved. Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published simultaneously -
WO 2017/066488 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2017/066488 A l 2 0 April 2017 (20.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/485 (2006.01) A61P 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/5415 (2006.01) A61P 1/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 16/0569 10 HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 13 October 2016 (13.10.201 6) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/240,965 13 October 2015 (13. 10.2015) US (84) Designated States (unless otherwise indicated, for every 62/300,014 25 February 2016 (25.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CHARLESTON LABORATORIES, INC. -
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