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Division Oncological Diagnostics and Therapy (E0100 / E010) Head: Prof Research Program E Division E0100 Radiological Diagnostics and Therapy Oncological Diagnostics and Therapy Division Oncological Diagnostics and Therapy (E0100 / E010) Head: Prof. Dr. Gerhard van Kaick (- 9/02), Priv.-Doz. Dr. Stefan Delorme (acting, 10 - 12/02)*) Scientists Most of our clinical projects evaluate technical improve- Priv.-Doz. Dr. Stefan Delorme ments in the field of Magnetic Resonance Imaging which Dr. Ljubica Dukic (1/02 -) are developed in close cooperation with the Division of Priv.-Doz. Dr. Marco Essig Biophysics (E0200). New methods are mainly related to Dr. Christian Fink functional imaging, e.g, of perfusion, diffusion, or metabo- Dr. Stefan Heckl (- 5/02) lism in tumors. We intend to obtain more information on Dr. Fabian Kießling the biological behavior of tumors, particularly their aggres- Dr. Martin Krix siveness and their response to radiotherapy, chemother- Dr. Matthias Lichy apy, or novel approaches, such as antiangiogenic treat- Dr. Dagmar Liebermann (½) ment. Together with E0200, we are evaluating new devel- Dr. Michael Puderbach (7/02 -) opments in interventional MRI, i.e., MR-guided treatment Dr. Cornelia Rehm using intravascular catheters or percutaneous probes for Priv.-Doz. Dr. Heinz-Peter Schlemmer (-5/02) local drug delivery or, e.g., thermal ablation. Priv.-Doz. Dr. Stefan Schönberg (-10/01) Besides MRI, multiphasic, contrast-enhanced spiral CT Dr. Bram Stieltjes (6/02 -) and new-developed ultrasound techniques are capable of Dr. Klaus Wasser (-6/02) assessing tissue perfusion. They are being evaluated in Dr. Marc-André Weber (-7/01) experimental and clinical settings for assessing therapeuti- cally induced changes in tumor perfusion, and are corre- Guest Scientists lated with reference measurements using MRI. Dr. Jutta Debus (5/02 -) Dr. Holger Hof (1-12/02) Since recently, we have opened a cooperation with the Di- Dr. Lin Jiang (China, Shanghai, -02/02) vision Differentiation and Carcinogenesis (B0600) where Dr. Maria-Katherina Ganten tumors in small animals (mice and rats) are examined non-invasively, using ultrasound or MRI. For anyone in- Technicians volved in studies with experimental tumors in animals, Peter Bontzol Adelheid Fuxa such functional examinations constitute a major gain, Jürgen Heiss Martina Jochim since until recently, an assessment of changes in a tumor Kathleen Knauer Barbara Rimmler (- 2/02) was only possible either with caliper size measurements, 221 Heike Streib-Retzbach (½) Susanne Wetzel or histologic preparation of the excised tumor. Marie Zuna (½) Besides numerous journal publications, four habilitation theses have been concluded in 2001 and 2002. With the retirement of Prof. Dr. Manfred Volm in January *) The founder and head of the Division Oncological Diag- 2000, his working group was closed. Publications of his nostics and Therapy, Prof. G. van Kaick, retired in Septem- group which have been published or accepted within the ber 2002. Priv.-Doz. S. Delorme acted temporarily as report period are listed separately below. Since January head. Since January 2003 Prof. Hans-Ulrich Kauczor is 2002, the working group Positron Emission Tomography head of the Division. (headed by Prof. Strauss) belongs to the Clinical Coopera- tion Unit Nuclear Medicine (E0600), headed by Prof. Haberkorn. This group’s publications that refer to its activi- ties until end of 2001 and are meanwhile published or in press are also listed separately. Their activities, however, are reported in detail by E0600. Publications by the groups of Prof. Strauss and Prof. Volm (* = external co-author) [1] Dimitrakopoulou-Strauss A; Strauss LG; Burger C*: Quantita- tive PET-studies in pretreated melanoma patients: a comparison of F-18-DOPA to F-18-FDG and O-15-water using compartment and non-compartment analysis. Journal of Nuclear Medicine, 42 (2001) 248-256. [2] Dimitrakopoulou-Strauss A; Strauss LG; Burger C*; Mikolajczyk K*; Lehnert T*; Bernd L*; Ewerbeck V*: Fractal di- mension based on box counting: A new parameter for the quantifi- cation of dynamic PET studies. Journal of Nuclear Medicine, in press. DKFZ 2003: Research Report 2001/2002 Research Program E Division E0100 Radiological Diagnostics and Therapy Oncological Diagnostics and Therapy [3] Dimitrakopoulou-Strauss A; Strauss LG; Schwarzbach M*; [20] Volm M; Koomägi R; Rittgen W: Cellular predictive factors of Burger C*; Heichel T*; Willeke F*; Mechtersheimer G*; Lehnert drug resistance in non-small cell lung carcinomas. In: Method in T*: Dynamic PET 18F-FDG studies in patients with primary and Molecular Medicine. Lung Cancer Vol. 2. Diagnostic and Thera- recurrent soft tissue sarcomas: impact on diagnosis and correla- peutic Methods and Reviews. Driscoll B (Ed.) Totowa NJ: tion with grading. Journal of Nuclear Medicine, 42 (2001) 713- Humana Press (2003) in press 720. [21] Volm M; Sauerbrey A*; Zintl F*; Koomägi R; Efferth T*: Pro- [4] Efferth T*; Koomägi R; Mattern J; Volm M: Expression profiles tein expression profile in newly diagnosed acute lymphoblastic of proteins involved in the xenotransplantability of non-small cell leukemia of children developing relapses. Oncology Reports lung cancer. International Journal of Oncology, 20 (2002) 391-395 (2003) in press. [5] Haberkorn U; Bellemann ME; Gerlach L; Morr I; Trojan H; Brix [22] Wu H; Dimitrakopoulou-Strauss A; Heichel TO*; Lehner B*; G; Doll J; Wießler M; van Kaick G: Positron emission tomography Bernd L*; Ewerbeck V*; Burger C*; Strauss LG: Quantitative of 2-fluror-2-deoxyglucose uptake in rat prostate adenocarcinoma evaluation of skeletal tumours with dynamic FDG PET: SUV in during chemotherapy with glucosylifosfamide. Nuclear Medicine comparison to patlak analysis. European Journal of Nuclear Medi- and Biology (2003) in press. cine, 28 (2001) 704-710. [6] Koomägi R; Zintl F*; Sauerbrey A*; Volm M: Vascular endothe- [23] Zhou X*; Frohlich ED*; Clorius JH; Haufe S: Functional and lial growth factor in newly diagnosed and recurrent childhood structural involvement of afferent and efferent glomerular arteri- acute lymphoblastic leukemia as measured by real-time quantita- oles in hypertension. Americal Journal of Kidney, 37 (2001) 1092- tive polymerase chain reaction. Clinical Cancer Research 7 1097. (2001) 3381-3384 [7] Masanek U*; Stammler G*; Volm M: Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P- glycoprotein 170 and PKC isoenzymes with antisense oligonucle- otides. Journal of Experimental Therapeutics and Oncology 2 (2002) 37-41 [8] Mattern J, Koomägi, R, Volm M: Characteristics of long-term survivors of untreated lung cancer. Lung cancer 36 (2002) 277- 282. [9] Mattern J: Role of angiogenesis in drug resistance. Anticancer Research, 21 (2001) 4265-4270 [10] Mattern J; Koomägi R; Volm M: Characteristics of long-term survivors of untreated lung cancer. In: Lung Cancer. Pontifex G (Ed.) Amsterdam: Excerpta Medica (2003) in press. [11] Mattern J; Koomägi R; Volm M: Expression of drug resis- tance gene products during progression of lung carcinomas. Anti- 222 cancer Research (2003) in press. [12] Mattern J; Volm M: Clinical estimation of the rate of lung can- cer. Anticancer Research, 21 (2001) 4067-4070. [13] Schwarzbach M*; Dimitrakopoulou-Strauss A; Mechtersheimer G*; Hinz U*; Willeke F*; Cardona S*; Attigah N*; Strauss LG; Herfarth C; Lehnert T: Assesment of soft tissue le- sions suspicious for liposarcoma by F18- deoxyglucose (FDG) positron emission tomography (PET). Anticancer Research, 21 (2001) 3609-3614. [14] Strauss LG; Dimitrakopoulou-Strauss A: Positronenemissionstomographie (PET) in der onkologischen Diagnostik und Therapieplanung. In: Onkologie: Grundlagen, Diagnostik, Therapie, Enrwicklung 1995, Vol. 1. Zeller WJ, zur Hausen H (Eds.) München-Landsberg: Ecomed (2001) Chapter III-5 [15] Strauss LG; Kontaxakis G; Dimitrakopoulou-Strauss A: Per- formance characteristics of iterative image reconstruction for rou- tine use in positron emission tomography. Alasbimn 3 (13) Octo- ber 2001, www.alasbimnjournals.cl/revistas/13/strauss.html. [16] Volm M and Koomägi R: Case revies: Prognostic relevance of angiogenic, proliferative and apotpotic factors in lung carcino- mas. In: Methods in Molecular Medicine. Lung Cancer Vol. 1: Mo- lecular Pathology methods and Reviews. Driscoll B (Ed.) Totowa NJ: Humana Press (2002) 271-284 [17] Volm M; Koomägi R; Mattern J; Efferth T*: Expression profile of genes in non-small cell lung carcinomas from long-term surviv- ing patients. Clinical Cancer Research (2003) in press. [18] Volm M; Koomägi R; Mattern J; Efferth T*: Expression pro- files involved in drug resistance of non-small cell lung cancer. Britisch Journal of Cancer (2003) in press. [19] Volm M; Koomägi R; Mattern J; Efferth T*: Protein expression profile of primary squamous cell lung carcinomas indicative for the incidence of metastases. Clinical and Experimental Metasta- sis (2003) in press. DKFZ 2003: Research Report 2001/2002 Research Program E Division E0100 Radiological Diagnostics and Therapy Oncological Diagnostics and Therapy Magnetic Resonance Imaging in Oncology the Division Differentiation and Carcinogenesis (B0600), (E0101) where we non-invasively monitor tumor growth and angio- genesis and evaluate the effects of anti-angiogenic sub- S. Delorme, M. Essig, C. Fink, F. Kießling, M. Krix, stances. M. Lichy, C. Rehm, H.-P. Schlemmer, B. Stieltjes, K. Wasser, M.-A. Weber Dynamic MR imaging For dynamic MRI, images or image stacks are rapidly ac- Magnetic resonance imaging (MRI) has become an in- quired after intravenous contrast
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