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Borderline Ovarian Mucinous Cystadenoma with Invasion Of Bull. Eur. Ass. Fish Pathol., 34(1) 2014, 25 Borderline ovarian mucinous cystadenoma with ȱȱȱȱȱęȱ Carassius auratus (L.) L. A. Romano1Șǰȱǯȱ ě2ǰȱǯȱû2, R. V. Rodrigues3, M. B. Tesser3, M. A. R Garrido-Pereira1 and L. A. Sampaio3 1ȱàȱȱ ȱȱȱȱȱǰȱ ȱȱęǰȱȱ ȱȱȱ ǯȱ¡ȱȱŚŝŚǰȱȱşŜǯŘŖŗȬşŖŖǰȱȱ ǰȱǰȱDzȱ2 Programa de Pós- ³¨ȱȱǰȱȱȱȱȱ ǯȱ¡ȱȱŚŝŚǰȱȱşŜŘŖŗȬşŖŖǰȱ ȱ ǰȱǰȱDzȱ3ȱàȱȱȱȱȱǰȱ ȱȱęǰȱ ȱȱȱȱ ǯȱ¡ȱȱŚŝŚǰȱȱşŜŘŖŗȬşŖŖǰȱȱ ǰȱǰȱ Abstract ȱȱȱȱ¢ȱȱȱȱęǯȱȱȱȱ¡ȱ ȱȱȱȱȱȱȱȱ¢ȱȱȱ¡ȱ¢ȱȱȱȱ with basally situated nuclei and abundant intracellular mucins stained with Alcian blue. Sections ȱȱȱ ȱȱȱȱȱȱȱȱ¢ȱ- ȱ ȱȱȱȬȱǯȱȱȱȱ ȱȱ ¢ȱȱĴȱȱȱȱ ŝȱȱȱȱȱ¢ǯȱ ȱȱȱȱȱ ȱȱȱ ȱȱ ŝȱ¢ǯȱȱ¢ȱȱ ¢ȱŝȱǻ ŝǼȱ¡ȱȱȱȱ ȱȱȱȱȱȱě- ȱȱ ȱȱǰȱȱȱ¡ȱȱȱȱ ŝȱȱȱ ȱȱȱ ¢ȱȱȱȱȱȱ¢ȱȱ¢ȱȱȱȱȱ¢ǯ Introduction ȱęȱȱȱȱȱȱ ȱǻęǰȱǰȱȱǼǯȱ ȱȱȱǰȱ ȱȱŘŖǰŖŖŖȱ ¢ǰȱȱęȱȱęȱȱ known species. Their diversity and placement in is largely based on mammalian criteria (Ma- the phylogenetic tree make them ideal subjects sahito et al., 1998; Romano and Marozzi, 2004; ȱȱȱǰȱ- Romano et al., 2010). ing broader knowledge about basic mecha- nisms, in comparison to studies limited only to ȱȱȱȱȱȱȱȱ mammalian models. Previously, such studies in mammals and birds have been reported in have primarily dealt with tumors in the higher ęǯȱȱ¢ȱęǰȱ Ȭȱ vertebrates (mammals and bird); considerably ȱȱȱȱȱęǰȱ- ȱĴȱȱȱȱȱȱ ȱ ing viral-induced dermal sarcomas in walleye, * Corresponding author’s e-mail: [email protected] 26, Bull. Eur. Ass. Fish Pathol., 34(1) 2014 Stizostedion vitreumȱǻǼǰȱȱĚ¡Ȭ in 50 mL H2O2c. Counterstaining was then associated hepatocellular adenomas and carci- ȱ ȱ¡¢ȱǻ ȱȱǯǰȱŗşŞŗǼǯ nomas in rainbow trout, ¢ȱ¢ ǻǼǰȱȱȱȱȱ ȱ¢ȱȱ Results sporadic tumours in numerous other species The tumour was cystic and multilobulat- ǻȱȱǯǰȱŗşŝŗDzȱǰȱŘŖŗŘǼǯ ed with abundant mucins (Figure 1). Histo- pathological examination showed the tumour Materials and methods ȱȱȱȱȱ¢ȱȱ Massive abdominal enlargements were ob- that exhibited typical tall columnar cells with ȱȱȱȱęǰȱCarassius auratus basally situated nuclei and abundant intracellu- ǻǯǼȱȱȱȱęȱȱǻȱ lar mucins stained with Alcian blue (Figure 2). ǰȱǼǯȱȱęǰȱȱ ȱ¢ȱȱ ¢ȱ¢ȱȱȱ¢ȱȱ ǰȱȱȱ ȱȱŚŜŖȱȱȱȱȱȱ ȱǯȱ ȱȱ¢ǰȱȱęȱȱ ȱřŚřȱǯȱȱ¢ǰȱȱȱȱŗşȱȱȱ ęȱȱȱ¢ȱȱ- ȱ ȱȱȱȱȱ¢ǯȱ ȱȱ ȱȱȱĴǯ ȱȱȱȱ ȱę¡ȱȱŗŖƖȱ ěȱǰȱȱȱĜǰȱ- A transitional zone was observed between the tioned at 3 to 5 μm, and stained with haema- classical mucinous cystadenoma and papillary toxylin and eosin and alcian blue. In addition ǯȱȱȱȱȱ¢ȱȱ Ȭě- histological sections were also stained using entiated mucinous cells, the cysts were lined by immunohistochemical procedures, according ¢ȱȱȱ ȱęȱȱ ȱ ȱȱęȱȬȬ¡ȱ¡ȱ ȱȱ¢ǯȱȱȱȱȱ ȱ technique.2 This involved tissue slides being ȱȱȱȱȱȱȱ Ĝǰȱȱ ȱ¡¢ȱȱȱ- mucinous tumour associated with clusters ¢ȱ ȱȱȱěȱȱǻ- ȱȬȱǯȱȱȱ ȱǰȱşŖǰȱŞŖǰȱŝŖǰȱśŖƖǼǯȱȱȱ epithelial structures were prominent and the peroxidase activity was blocked by incubating ȱȱȱȱȱǻȱřȱȱŚǼǯ ȱȱȱŘŖȱȱȱŖǯřƖȱ ŘŘȱȱȱśƖȱ The immunohistochemical studies showed ȱǯȱȱ ȱȱȱȱ ȱ¢ȱȱĴȱȱ ȱȱȦŖǯŖśƖȬ ȱŘŖȱǰȱ¢ȱ ȱȱ ŝȱȱȱȱȱ¢- ȱȱȱȱŗȦŗŖŖȱa, in a tadenoma. The invasive stromal implant also 10% PBS bovine serum albumin (BSA) solution ȱȱȱ ȱȱ ŝȱ¢ȱ ȱȱȱȱřŖȱȱȱȱȱ (Figure 5). ǯȱȱǰȱȱ¢ȱȬȱ¢- ȱŝȱǻ ŝǼȱ¢b was added at a Discussion ȱȱŗDZŘŖŖȱȱȬȱŗŖƖǰȱȱȱȱ ȱ ȱ ęȱ ȱ ȱ ǰȱ were incubated overnight at 41°C in humid Cyprinus carpio L., are well represented in the ǯȱȱ ȱ ȱ¢ȱȱȱ ǯȱȱȱȱȱȱ ȱȱŝȱȱȱȱśŖȱȱřŖǯřȬ- ȱȱęȱȱȱ¢ǰȱ¢ȱȱȱ obenzidine solution containing 1% PBS-BSA ȱȱȱǯȱ ęȱȱȱ ȱ ǯȱǯȱǯȱȱǯǰȱřŚǻŗǼȱŘŖŗŚǰȱŘŝ Figure 1.ȱ ȱȱȱȱȱ¢ȱȱȱȱ¢ȱ¢ȱ ȱȱ walls with abundant mucins. Bar = 1 cm. Insert: Carassius auratus with massive abdominal enlargements. Bar = 4.5 cm Figure 2. Mature cyst showing typical tall columnar cells with basally situated nuclei and abundant intracellular mucins (arrow) supported connective tissue (SC). Haematoxylin and eosin. Bar = 200 μm 28, Bull. Eur. Ass. Fish Pathol., 34(1) 2014 Figure 3.ȱȱȱȱȱȱ¢ȱȱȱ ¢ǯȱ ȱ ȱ ȱȱȱȱ¢ȱȱ ȱȱȱȱȱǻ Ǽǯȱ ¡¢ȱ and eosin. Bar = 50 μm Figure 4.ȱȱȱ¢ȱȱȱ¢ȱ ȱ¢ȱȱ¢ȱȱ ǻ Ǽȱȱȱȱȱ¢ȱȱȱȱȱǻȘǼȱ ¡¢ȱȱǯȱȱƽȱŗŖŖȱ μm Bull. Eur. Ass. Fish Pathol., 34(1) 2014, 29 Figure 5.ȱȱ ȱȱȱȱȱ¡ȱ ŝȱ¡ȱǻ ǼǯȱȬ ŝȱ ȱ haematoxylin counterstain. Bar = 100 μm adapted to environments that are suboptimal or embryonic carcinomas. Squamous cell nests ȱȱȱȱęǯȱȱȱȱȱ ȱȱ ȱ¢ȱȱȱȱ ȱȱȱ¢ȱȱ¡¢ȱȱȱ tumor, but no mucinous cystadenoma was ob- damage caused by toxins that may be carcino- served. Thus, ovarian tumours in carp may have ǯȱȱ¢ȱȱȱȱȱȱěȱ diverse histogenetic origins and most likely ȱ¡ȱȱ¢ȱ¡ȱȱęȱ ȱȱȱȱȱȱȱȱ ȱȱȱȱȱȱǯ mesenchyme. Abdominal enlargement associated with ovarian ȱȱ¢ǰȱȱěȱȱ- neoplasia was previously described in eight ȱȱȱȱȱ¢ȱȱ 4-6-year-old adult carp living in breeding ponds primary ovarian mucinous tumours (atypical ȱȱęȱȱȱ ȱǻ ǰȱŘŖŖśǼǯȱ ȦȱȱǼȱȱȱ ȱȱ ȱ¢ȱęȱȱ Ĝȱȱȱȱȱȱ- ¢ȱȱȱȱ¢ǰȱ- phology. bly teratoid in nature. Another study described 21 ovarian neoplasias in ornamental hybrid ȱ¢ȱȱȱ¢ȱȱȱ ȱǻ ȱȱ¢ǰȱŗşŝŞǼǯ Histologi- epithelial origin and represent a unique inter- cally, these neoplasias exhibited considerable mediate stage between benign cystadenomas ǰȱȱ¢ȱ ȱȱ¢ȱȱ ȱǯȱ¢ȱȱȱȱ ȱ¢ȱȱȱȱȱȱȱȱ ¢ȱ¢ȱȱȱȱȱ¢ȱ dysgerminoma, granulosa or theca cell tumors ȱȱȬȱȱȱ¢ȱȱ 30, Bull. Eur. Ass. Fish Pathol., 34(1) 2014 ȱȱȱȱǯȱȱ ¢ȱȱ ȱȱȱ£- ȱ¢ȱȱȱȱȱ ȱȱȱǰȱȱǻȱȱ ȱȱȱȱȱǻǰȱ ȱřŖŗŖŖŘȦŘŖŗŘȬŜȱȱřŖŞŖŗřȦŘŖŖşȬřǼǯȱ 2005). References The World Health Organization (WHO) classi- Acs G (2005). Serous and mucinous borderline ǻ ȱȱǼȱȱȱȱ ęȱȱȱȱȱȱȃȱ ovary. American Journal of Clinical Pathology tumours”; they have been too widely recognized 123, ŗřȬśŝǯ ȱȱȱȱȃ ȱȱȄȱ ĵȱǰȱ ¢ȱ ǰȱ ȱǰȱ ȱ ǰȱ ȱ ȱȱȃȱȱǰȄȱ- MA and Burtom KL (2000). International nology that was accepted by the WHO in the ęȱȱȱȱȱ¢ǰȱ ¢ȱŘŖŖŖǯȱ¢ǰȱȱȱȱȱȱ 3th ed, World Health Organization (WHO), Geneva. ȃȱȱ¢ȱȱ ȱȱ- ȄȱȱȱȱǻĵǰȱȱǯǰȱŘŖŖŖǼǯȱ Hart WR (2005). Borderline epithelial tumors ȱȱ¢ǯȱModern Pathology 18, 33–50. ȱȱȱȱĚȱȱ Hsu SM, Raine L and Fanger H (1981). Use ȱ ȬȬ¡ȱ ¡ȱ ȱ ȱ ȱ ȱ ěȱ ȱ (ABC) in immunoperoxidase techniques: primary ovarian mucinous tumours and meta- a comparison between ABC an unlabeled static mucinous carcinomas in the human ovary. antibody (PAP) procedures. Journal of ȱ¢ȱȱ¢ȱŝȱǻ ŝǼȱ¡ȱȱ Histochemistry & Cytochemistry 29ǰȱśŝŝȮśŞśǯ restricted and allows ovarian mucinous tumors ȱȱȱ¢ȱȱǻŗşŝŞǼǯȱȱ ȱȱěȱȱ ȱȱ neoplasia in ornamental hybrid carp ǰȱȱȱ¡ȱȱȱȱ ŝȱȱ (Nishikigoi) in Japan. ȱȱȱ ȱ ȱ¢ȱȱ. 298, 330–341. ȱ ȱȱȱ¢ȱȱȱȱ ȱȱ¢ȱȱ¢ȱ- Lee DL, Wales JH and Sinnhuber RO ǻŗşŝŗǯȱ ȱ ȱȱȱȱ¢ǯȱ¢ȱȱ ȱĚ¡ȱȱȱ ȱȱ ȱȱ ȱ¢ȱ ¢ȱ- trout by methyl-malvalate and sterculate. ¢ȱȱȱ ȱŝȱǻşŞƖǼȱǻȱ Cancer Research 31, 960–963. 2011). Ovarian neoplasms have been reported in Masahito P, Ishikawa T and Sugano H (1998). ęǰȱȱȱȱ¢ȱȱ Fish tumors and their importance in cancer ȱ¢ȱ ȱȱȱȱȱǰȱ research. Japanese Journal of Cancer Research 79, 545–555. ȱȱ ȱȱȱȱȱęȱȱ case (Hart, 2005). Mc Cluggage WG (2011). Immunohistochemistry in the distinction between primary and metastatic Acknowledgments ovarian mucinous neoplasms. Journal of ȱȱ ȱȱȱ¢ȱ - Clinical Pathology 65, 596–600. ȱȱ£ȱȱȱȱȱ- Roberts RJ (2012). Fish Pathology. 4th ed. Wiley ȱȱȱǯȱ ěǰȱǯȱûǰȱ ǰȱ¡ǰȱ ǯ E.P. Gusmão, M.A. Garrido-Pereira. L.A.L.A. Romano LA and Marozzi VA (2004). Epithelio- Romano and L.A. Sampaio, who received pro- reticular cell thymoma in carp, Cyprinus Bull. Eur. Ass. Fish Pathol., 34(1) 2014, 31 carpio L. A case with ultrastructural study. Journal of Fish Diseases 27ǰȱřŜşȮřŝřǯ Romano LA, Tabata YA and Alexandrino AC (2010). Histopathological and ȱ ȱ ȱ ȱȱȱȱȱ ȱ trout (¢ȱ¢). Acta Scientiae Veterinariae 38, 319–322..
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