DOCSLIB.ORG

Lung Transplantation in the Third Millennium Third the in Lung Transplantation in the Third Millennium

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Lung Transplantation in the Third Millennium Third the in Lung Transplantation in the Third Millennium AME Medical Book 1A025 1A025 Lung Transplantation in the Third Millennium Transplantation Lung in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta www.amegroups.com Editors: Federico Venuta Raemdonck Dirk Van Lung Transplantation in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta AME Publishing Company Room C 16F, Kings Wing Plaza 1, NO. 3 on Kwan Street, Shatin, NT, Hong Kong Information on this title: www.amegroups.com For more information, contact [email protected] Copyright © AME Publishing Company. All rights reserved. This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of AME Publishing Company. First published in 2018 Printed in China by AME Publishing Company Editors: Dirk Van Raemdonck, Federico Venuta Lung Transplantation in the Third Millennium (Hard Cover) ISBN: 978-988-77840-4-3 AME Publishing Company, Hong Kong AME Publishing Company has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. The advice and opinions expressed in this book are solely those of the authors and do not necessarily represent the views or practices of the publisher. No representation is made by the publisher about the suitability of the information contained in this book, and there is no consent, endorsement or recommendation provided by the publisher, express or implied, with regard to its contents. I LUNG TRANSPLANTATION IN THE THIRD MILLENNIUM (FIRST EDITION) EDITORS Greg L. Calligaro Division of Pulmonology, Department of Medicine, Groote Dirk Van Raemdonck Schuur Hospital, Cape Town, South Africa Department of Thoracic Surgery, University Hospitals Leuven and Department of Clinical and Experimental Edward Cantu Medicine, KU Leuven University, Leuven, Belgium Division of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA Federico Venuta Department of Thoracic Surgery, Policlinico Umberto I Andrew Courtwright and University of Rome La Sapienza, Rome, Italy Division of Pulmonary and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA CONTRIBUTORS Xavier-Benoit D’Journo Michaela R. Anderson Department of Thoracic Surgery, Disease of the Division of Pulmonary, Allergy and Critical Care Medicine, Oesophagus and Lung Transplantations, Hôpital Nord, Department of Medicine, Columbia University Medical Aix- Marseille University, Marseille, France Center, New York, USA Hiroshi Date Selim M. Arcasoy The Department of Thoracic Surgery, Kyoto University Division of Pulmonary, Allergy and Critical Care Medicine, Graduate School of Medicine, Kyoto, Japan Department of Medicine, Columbia University Medical Center, New York, USA Stephanie Dizier Department of Thoracic Surgery, Disease of the Christian Benden Oesophagus and Lung Transplantations, Hôpital Nord, Division of Pulmonology, University Hospital Zurich, Aix- Marseille University, Marseille, France Zurich, Switzerland Christophe Doddoli Luke J. Benvenuto Department of Thoracic Surgery, Disease of the Division of Pulmonary, Allergy and Critical Care Medicine, Oesophagus and Lung Transplantations, Hôpital Nord, Department of Medicine, Columbia University Medical Aix- Marseille University, Marseille, France Center, New York, USA Lieven Dupont Mark Benzimra Department of Respiratory Diseases, Lung Transplantation Heart and Lung Transplant Unit, St Vincent’s Hospital, Unit, University Hospital Gasthuisberg KU Leuven, Sydney, Australia Leuven, Belgium Geoffrey Brioude Department of Thoracic Surgery, Disease of the Oesophagus and Lung Transplantations, Hôpital Nord, Aix- Marseille University, Marseille, France © AME Publishing Company. All rights reserved. www.amegroups.com II Elie Fadel Fabio Ius Service de Chirurgie Thoracique, Vasculaire et Department of Cardiothoracic, Transplant and Vascular Transplantation Cardio-pulmonaire, H pital Marie- Surgery, Hannover Medical School, Hannover, Germany Lannelongue, Le Plessis-Robinson, France; Universit Paris-Sud, Facult de M decine, Universit Paris-Saclay, Le Jérôme Le Pavec Kremlin Bic tre, France; UMR_S 999, Universit Paris- Service de Chirurgie Thoracique, Vasculaire et Sud, INSERM, H pital Marie Lannelongue, Le Plessis- Transplantation Cardio-pulmonaire, H pital Marie- Robinson, France Lannelongue, Le Plessis-Robinson, France; Universit Paris-Sud, Facult de M decine, Universit Paris-Saclay, Le Pierre-Emmanuel Falcoz Kremlin Bic tre, France; UMR_S 999, Universit Paris- Lung Transplantation Group, University Hospital Sud, INSERM, H pital Marie Lannelongue, Le Plessis- Strasbourg, Strasbourg, France; INSERM (French institute Robinson, France for health and medical research) 1260 Regenerative Nanomedecine, Translational Medicine Federation of Marc Leone Strasbourg, University of Strasbourg, Strasbourg, France Department of Anesthesiology, Hôpital Nord, Aix- Marseille University, Marseille, France Andrew John Fisher Institute of Transplantation, Freeman Hospital, Newcastle Gabriel Loor Upon Tyne, UK; Institute of Cellular Medicine, Faculty of Division of Cardiothoracic Transplantation and Circulatory Medical Sciences, Newcastle University, Newcastle Upon Support, Department of Surgery, Baylor College of Tyne, UK Medicine, Houston, TX, USA Allan R. Glanville Herve Mal Heart and Lung Transplant Unit, St Vincent’s Hospital, INSERM U1152, Université Paris Diderot, Paris, France Sydney, Australia Gilbert Massard Jens Gottlieb Lung Transplantation Group, University Hospital Department of Respiratory Medicine, Hannover Medical Strasbourg, Strasbourg, France; INSERM (French institute School, Hannover, Germany; Biomedical Research in End- for health and medical research) 1260 Regenerative stage and Obstructive Disease (BREATH), German Centre Nanomedecine, Translational Medicine Federation of for Lung Research (DZL), Hannover, Germany Strasbourg, University of Strasbourg, Strasbourg, France Lucile Gust Bryan F. Meyers Department of Thoracic Surgery, Disease of the Division of Cardiothoracic Surgery, Washington University Oesophagus and Lung Transplantations, Hôpital Nord, School of Medicine, St. Louis, MO, USA Aix- Marseille University, Marseille, France Letizia Corinna Morlacchi Sébastien Hascoët Internal Medicine Department, Respiratory Unit and Cystic Universit Paris-Sud, Facult de M decine, Universit Paris- Fibrosis Adult Centre, Ca’ Granda Foundation IRCCS Saclay, Le Kremlin Bic tre, France; Service de Cardiop Ospedale Maggiore Policlinico, Milano, Italy; Department diatrie, Centre de R f rence des Malformations Cardiaques of Pathophysiology and Transplantation, Università degli Cong nitales Complexes M3C, H pital Marie-Lannelongue, Studi di Milano, Milano, Italy Le Plessis-Robinson, France Morvern Isabel Morrison Ilhan Inci Institute of Transplantation, Freeman Hospital, Newcastle Department of Thoracic Surgery, University Hospital, Upon Tyne, UK; Institute of Cellular Medicine, Faculty of University of Zurich, Zurich, Switzerland Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK © AME Publishing Company. All rights reserved. www.amegroups.com III Arne Neyrinck Melanie P. Subramanian Department of Amesthesiology, Lung Transplantation Unit, Division of Cardiothoracic Surgery, Washington University University Hospital Gasthuisberg KU Leuven, Leuven, School of Medicine, St. Louis, MO, USA Belgium Paolo Tarsia Mario Nosotti Internal Medicine Department, Respiratory Unit and Cystic Thoracic Surgery and Lung Transplantation Unit, Milano, Fibrosis Adult Centre, Ca’ Granda Foundation IRCCS Italy Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Anne Olland Studi di Milano, Milano, Italy Lung Transplantation Group, University Hospital Strasbourg, Strasbourg, France; INSERM (French Gabriel Thabut institute for health and medical research) 1260 Service de pneumologie et transplantation pulmonaire, Regenerative Nanomedecine, Translational Medicine Hôpital Bichat, Paris, France Federation of Strasbourg, University of Strasbourg, Strasbourg, France Pascal-Alexandre Thomas Department of Thoracic Surgery, Disease of the Amit Parulekar Oesophagus and Lung Transplantations, Hôpital Nord, Section of Pulmonary, Critical Care and Sleep Medicine, Aix- Marseille University, Marseille, France CHI St. Luke’s Health-Baylor St. Luke’s Medical Center, Houston, TX, USA Delphine Trousse Department of Thoracic Surgery, Disease of the Thomas Leonard Pither Oesophagus and Lung Transplantations, Hôpital Nord, Institute of Transplantation, Freeman Hospital, Newcastle Aix- Marseille University, Marseille, France Upon Tyne, UK; Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Igor Tudorache Tyne, UK Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany Filip Rega Department of Cardiac Surgery, University Hospitals Anke Van Herck Leuven, Leuven, Belgium; Department of Cardiovascular Department of Respiratory Diseases, University Hospitals Sciences, KU Leuven University, Leuven, Belgium Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), Division Steffen Rex of Respiratory Diseases, KU Leuven, Leuven, Belgium Department of Cardiovascular
Load more

Recommended publications
  • History of Lung Transplantation Akciğer Transplantasyonu Tarihçesi
    REVIEW History of Lung Transplantation Akciğer Transplantasyonu Tarihçesi Gül Dabak Unit of Pulmonology, Kartal Kosuyolu Yüksek Ihtisas Teaching Hospital for Cardiovascular Diseases and Surgery, İstanbul ABSTRACT ÖZET History of lung transplantation in the world dates back to the early 20 Dünyada akciğer transplantasyonu tarihçesi, deneysel çalışmala- th century, continues to the first clinical transplantation performed rın yapılmaya başlandığı 20. yüzyılın ilk yıllarından itibaren Ja- by James Hardy in the United States of America in 1963 and comes mes Hardy’ nin Amerika Birleşik Devletleri’nde 1963’te yaptığı to the present with increased frequency. Over 40.000 heart-lung ilk klinik transplantasyona uzanır ve hızlanarak günümüze gelir. and lung transplantations were carried out in the world up to 2011 yılına kadar dünyada 40,000’in üzerinde kalp-akciğer ve 2011. The number of transplant centers and patients is flourishing akciğer transplantasyonu yapılmıştır. Transplantasyon alanındaki in accordance with the increasing demand and success rate in that artan ihtiyaca ve başarılara paralel olarak transplant merkezleri arena. Lung transplantations that started in Turkey at Sureyyapasa ve hasta sayıları da giderek artmaktadır. Türkiye’de 2009 yılında Teaching Hospital for Pulmonary Diseases and Thoracic Surgery Süreyyapaşa Göğüs Hastalıkları ve Cerrahisi Eğitim ve Araştırma in 2009 are being performed at two centers actively to date. This Hastanesi’ nde başlayan akciğer transplantasyonları günümüzde review covers a general outlook on lung transplantations both in iki merkezde aktif olarak yapılmaktadır. Bu derlemede, ülkemiz- the world and in Turkey with details of the first successful lung deki ilk başarılı akciğer transplantasyonu detaylandırılarak dün- transplantation in our country. yada ve ülkemizdeki akciğer transplantasyonu tarihçesi gözden Keywords: Lung transplantation, heart-lung transplantation, his- geçirilmektedir.
    [Show full text]
  • Historical Perspectives of Lung Transplantation: Connecting the Dots
    4531 Review Article Historical perspectives of lung transplantation: connecting the dots Tanmay S. Panchabhai1, Udit Chaddha2, Kenneth R. McCurry3, Ross M. Bremner1, Atul C. Mehta4 1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA; 2Department of Pulmonary and Critical Care Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA; 3Department of Cardiothoracic Surgery, Sydell and Arnold Miller Family Heart and Vascular Institute; 4Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA Contributions: (I) Conception and design: TS Panchabhai, AC Mehta; (II) Administrative support: TS Panchabhai, RM Bremner, AC Mehta; (III) Provision of study materials or patients: TS Panchabhai, U Chaddha; (IV) Collection and assembly of data: TS Panchabhai, U Chaddha, AC Mehta; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Atul C. Mehta, MD, FCCP. Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Staff Physician, Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. Email: [email protected]. Abstract: Lung transplantation is now a treatment option for many patients with end-stage lung disease. Now 55 years since the first human lung transplant, this is a good time to reflect upon the history of lung transplantation, to recognize major milestones in the field, and to learn from others’ unsuccessful transplant experiences. James Hardy was instrumental in developing experimental thoracic transplantation, performing the first human lung transplant in 1963. George Magovern and Adolph Yates carried out the second human lung transplant a few days later.
    [Show full text]
  • HARBIN. NOVEMBER 2017. Sergio
    POWER OVER LIFE AND DEATH Natalie Köhle ARBIN. NOVEMBER 2017. Sergio NESS is NOT in the BRAIN, which seeks HCanavero and Ren Xiaoping 任晓 to prove the existence of an eternal 平 announced that the world’s first hu- soul on the basis of near death experi- man head transplant was ‘imminent’. ence, as well as two guides on seducing They had just completed an eight- women. He also drops flippant refer- een-hour rehearsal on two human ca- ences to Stalin or the Nazi doctor Josef davers, and now claimed to be ready Mengele. for the real deal: the transplant of a human head from a living person with a degenerative disease onto a healthy, but brain-dead, donor body.1 Ren — a US-educated Chinese orthopaedic surgeon, was part of the team that performed the first hand transplant in Louisville in 1999. Canavero, an Italian, and former neu- rosurgeon at the university of Turin, is the more controversial, maverick per- sona of the team. In addition to many respected scientific publications, he Frankenstein’s Monster from The Bride of Frankenstein (1935) published Immortal: Why CONSCIOUS- Source: Commons Wikimedia 276 tor function and sensation. It would 277 also depend on the unproven capacity of the human brain to adjust to — and gain control over — a new body and a new nervous system without suffering debilitating pain or going mad.2 So far, Ren and Canavero have Sergio Canavero transplanted the heads of numerous Source: 诗凯 陆, Flickr lab mice and one monkey, and they Ren and Canavero see the head have also severed and subsequently Power over Life and Death Natalie Köhle transplant, formally known as cepha- mended the spinal cords of several POWER losomatic anastomosis, as the logical dogs.
    [Show full text]
  • Lung Transplantation Adriaan Myburgh
    Lung Transplantation Adriaan Myburgh ! UNIVERSITY OF CAPE TOWN ! Department of Anaesthesia and Perioperative Medicine ! ! ! ! ! ! ! Disclosure Jenna Lowe “ Get me to 21” • 4065 Donors Phalo - URE History • 1947: Vladimir Demikhov performs first successful animal lung transplantation • 1963: James Hardy performs first human lung transplantation in Jackson Mississippi 3 December 1967: First Human heart transplant Denise Darvall to Louis Washkansy • 1986: Joel Cooper performs first successful human double lung transplantation • 2001: Stig Steen performed first successful Non Heart Beating lung transplantation • 2007: Stig Steen performs first ex-vivo reconditioning human lung transplantation Recipients Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions Orens JB et al. J Heart Lung Transplant 2006; 25: 745-55 Contraindications ? Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions ECMO Bridge-to-transplant Lung assist device (Novalung®) ECMO Strueber M. Curr Opin Organ
    [Show full text]
  • The Morality of Head Transplant: Frankenstein’S Allegory
    5 THE MORALITY OF HEAD TRANSPLANT: FRANKENSTEIN’S ALLEGORY Aníbal Monasterio Astobiza1 Abstract: In 1970 Robert J. White (1926-2010) tried to transplant the head of a Rhesus monkey into another monkey’s body. He was in- spired by the work of a Russian scientist, Vladimir Demikhov (1916- 1998), who had conducted similar experiments in dogs. Both Demikhov and White have been successful pioneers of organ transplantation, but their scientific attempts to transplant heads of mammals are often remem- bered as infamous. Both scientists encountered important difficulties in such experiments, including their incapacity to link the spinal cord, which ended up by creating quadriplegic animals. In 2013, neurosurgeon Sergio Canavero claimed his capacity and plan to carry out the first human head 1 I am grateful to the Basque Government sponsorship for carrying out a posdoc- toral research fellowship at the Uehiro Centre for Practical Ethics of the University of Oxford, and to the latter institution for its warm welcome. Also, I would like to thank David Rodríguez-Arias for his invaluable comments and suggestions for the improvement of this paper. As usual, any error is solely the author’s responsibility. This work was carried out within the framework of the following research projects: KONTUZ!: “Responsabilidad causal de la comisión por omisión: Una dilucidadión ético-jurídica de los problemas de la acción indebida” (MINECO FFI2014-53926-R); “La constitución del sujeto en la interacción social: identidad, normas y sentido de la acción desde la perspectiva de la filosofía de la acción, la epistemología y la filosofía experimental” (FFI2015-67569-C2-2-P), and “Artificial Intelligence and Biotechnol- ogy of Moral Enhancement Ethical Aspects” (FFI2016-79000-P).
    [Show full text]
  • An Overview of Anesthesia Practices for Heart Transplant in India
    Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 3 Issue 12 December 2019 Review Article An Overview of Anesthesia Practices for Heart Transplant in India Sandeep Kumar Kar* and Pallav Mishra Assistant Professor, Cardiac Anesthesiology, IPGMER, Kolkata, India *Corresponding Author: Sandeep Kumar Kar, Assistant Professor, Cardiac Anesthesiology, IPGMER, Kolkata, India. Received: November 20, 2019 DOI: 10.31080/ASPS.2019.03.0449 Abstract is growing. Immunosuppressive agents have dramatically improved success of heart transplantation. Non-ischemic cardiomyopathy Heart transplant has seen a significant progress the number of patients with heart failure qualifying for cardiac transplantation has surpassed ischemic cardiomyopathy as need for transplantation. The use of bridge therapy with mechanical circulatory support has improved both short-term and long-term survival of heart transplant recipients has gradually improved over time Keywords: Heart Transplant; Non-Ischemic Cardiomyopathy; Mechanical Circulatory Assist Introduction st Organ Transplantation in India under aegis of National Organi- Dr. Christiaan 1 successful adult heart transplant on Mr. Louis Neethling Washkansky 3 December 1967 at Groote Schuur zation Tissue Transplantation Organization (NOTTO) setup under Barnard hospital Cape town, South Africa Directorate General of Health Services established to oversee all Caves and Transvenous endomyocardial biopsy for diagnosis donation and transplantation activities. In this regard, the entire Colleagues of immune rejection of heart transplant in 1970. country is having the following setup at National, Regional and Jean Francois Immunosuppressive effects of cyclosporin A as State Level. Borel preventive strategy to cardiac rejection in 1976. Bruce Reitz National and Norman 1st successful combined heart lung transplant [4]. (NOTTO) Level Shumway Regional KEM Guwahati Table 2 PGIMER IPGME and RGGGH Level Hospital Medical Chandigarh R Kolkata Chennai (ROTTO) Mumbai College ents.
    [Show full text]
  • A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised
    MESTRADO INTEGRADO MEDICINA A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised Maria Inês dos Reis Rodrigues M 2019 A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program revised Maria Inês dos Reis Magalhães Rodrigues I [email protected] Mestrado Integrado em Medicina Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Orientador: Professor Doutor Humberto José da Silva Machado Professor Associado Convidado do Instituto de Ciências Biomédicas Abel Salazar Assistente Hospitalar Graduado Sénior de Anestesiologia do Centro Hospitalar do Porto Diretor do Serviço de Anestesiologia do Centro Hospitalar do Porto Adjunto da Direção Clínica do Centro Hospitalar do Porto Maio 2019 24 de maio de 2019 Agradecimentos Ao Professor Doutor Humberto Machado pela orientação, disponibilidade, interesse e apoio que sempre demonstrou, indispensáveis para a realização do presente trabalho. Aos meus pais e irmã, pelos valores transmitidos e por toda a ajuda e companheirismo ao longo do meu percurso de vida. i Resumo Introdução: O transplante pulmonar é atualmente uma opção terapêutica para doentes com doença pulmonar terminal. Nos últimos 30 anos verificou-se um constante crescimento na área da transplantação pulmonar e, com o desenvolvimento de novos fármacos imunossupressores e o aperfeiçoamento de técnicas cirúrgicas e de conservação de órgãos, houve um aumento da sobrevivência e da qualidade de vida dos doentes transplantados. Em Portugal, o programa de transplantação pulmonar teve início em 2001 no Hospital Santa Marta, Centro Hospitalar de Lisboa Central. Apesar de ser o único centro de transplantação pulmonar do país, um número crescente de transplantes pulmonares tem vindo a ser realizado, passando de 8 transplantes realizados em 2009 para 34 transplantes realizados em 2017.
    [Show full text]
  • Lung Transplant Consideration: Anesthesiologist Perspective
    ISSN: 2693-4965 DOI: 10.33552/OJCR.2020.04.000594 Online Journal of Cardiology Research & Reports Review Article Copyright © All rights are reserved by Sandeep Kumar Kar Lung Transplant Consideration: Anesthesiologist Perspective Sandeep Kumar Kar1* and Pallav Mishra2 Department of Cardiac Anesthesiology, Institute of Post Graduate Medical Education and Research, India *Corresponding author: Sandeep Kumar Kar, Department of Cardiac Received Date: August 07, 2020 Anesthesiology, Institute of Post Graduate Medical Education and Research, Kolkata, India. Published Date: October 21, 2020 Abstract Lung transplant has seen a significant progress since 1963 till this era. Worldwide lung transplant indications have broadened with time. Alpha 1 antitrypsin deficiency used to be the most common reason for transplant but now conditions like idiopathic pulmonary fibrosis, Cystic fibrosis, Non Cystic fibrosis bronchiectasis, lymphangioleiomyomatosis have become leading indications towards lung transplant. Relaxation of donor selection criteria management protocol preserving and optimizing lung function with development ex vivo perfusion techniques to recondition suboptimal lung has improved lung transplantation success. Post-transplant survival still poses challenge as median survival stands low around five years. Keywords: Lung transplant; Donor criteria; Ex vivo; Post-transplant Introduction country is having the following setup at National, Regional and Organ Transplantation in India under aegis of National State Level (Table 1 & 2). Lung transplant be considered for adults Organization Tissue Transplantation Organization (NOTTO) setup with chronic end stage lung disease meeting all of the following under Directorate General of Health Services established to oversee general criteria [5]. all donation and transplantation activities. In this regard, the entire Table 1: History of lung transplant.
    [Show full text]
  • Alternative Therapies for Orthotopic Heart Transplantation
    Alternative Therapies for Orthotopic Heart Transplantation Daniel J. Garry, M.D., Ph.D. Medical Grand Rounds, Department of Internal Medicine July 19, 2001 Disclosure: This is to acknowledge that Daniel Garry, M.D., Ph.D. has not disclosed any financial interests or other relationships with commercial concerns related directly or indirectly to this program. Dr. Garry will be discussing off-label uses in his presentation. BIOGRAPHICAL INFORMATION: Daniel J. Garry, M.D., Ph.D. Assistant Professor, Departments of Internal Medicine, Molecular Biology UT Southwestern Medical Center INTERESTS: Congestive Heart Failure/Cardiac Transplantation Basic science mechanisms·of stem cell biology & oxygen metabolism 2 Congestive heart failure (CHF) Therapeutic strategies for heart failure have evolved tremendously over the past several hundred years. Treatment of congestive heart failure (CHF) or what was referred to as "dropsy" was aimed initially at restoring a balance of fundamental elements and humors. In 1683, Thomas Sydenham recommended bleeding, purges, blistering, garlic and wine. Additional treatments were attempted and abandoned after unrewarding anecdotal experiences (i.e. death). Progress regarding the treatment of heart failure was evident with the introduction of amyl nitrate, mercurial diuretics, digitalis glycosides and bed rest in the early 20th century. Medical therapy for heart failure in the 1960's included digitalis, thiazide diuretics (introduced in 1962) and furosemide (introduced in 1965). The utilization of vasodilators for heart failure were implemented in the 1970's (nitroprusside in 1974 and hydralazine in 1977) and the first large, randomized, clinical trial for heart failure was not completed until 1986 (V-HeFf 1). Since then, the design and completion of a number of large, randomized, placebo-controlled clinical trials have established angiotensin-converting enzyme inhibitors and B-adrenergic receptor antagonists as the cornerstones of therapy.
    [Show full text]
  • Thoracic and Cardiovascular Surgery
    GREAT INSTITUTIONS One Hundred Years of History at Stanford University: Thoracic and Cardiovascular Surgery Y. Joseph Woo, MD, and Bruce A. Reitz, MD The history of thoracic and cardiovascular surgery at Stanford spans a century long period, beginning not long after the founding of Stanford University. Pioneering Stanford surgeons have made landmark discoveries and innovations in pulmonary, transplantation, thoracic aortic, mechanical circulatory support, minimally invasive, valvular, and congenital heart surgery. Fundamental research formed the foundation underlying these and many other advances. Educating and training the subsequent leaders of cardio- thoracic surgery has throughout this century-long history constituted a mission of the highest merit. New Stanford Adult Hospital Semin Thoracic Surg 27:388–397 I 2015 Elsevier Inc. All rights reserved. Central Message Keywords: History, Cardiovascular Surgery, Thoracic Surgery, Transplantation, Aortic Dissection Stanford: Upon a foundation of rigorous scien- tific investigation and dedicated teaching, Stan- ford thoracic and cardiovascular surgeons PRE-STANFORD UNIVERSITY Stanford Faculty in pioneered discoveries and innovations in pul- Lineage tracing of the history of Stanford Cardiothoracic 1914 and led the monary, transplantation, aortic, minimally inva- Surgery could be extended back to 1857, even before the Stanford surgical sive, and congenital heart surgery. founding of Stanford University. Elias Samuel Cooper, a San service at the San Francisco surgeon, authored “Report of an Operation to Francisco General Hospital2 (Fig. 2). Although he practiced a Remove a Foreign Body from Beneath the Heart” published broad spectrum of surgery, much of his clinical and experimental by the San Francisco Medico Chirurgical Association. The work and scholarly publications were in the arena of chest following year in 1858, Cooper founded the first medical surgery.
    [Show full text]
  • Norman Shumway
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Baumgartner et al PRESIDENTIAL BIOGRAPHY Presidentialprovided by BiographyElsevier - Publisher Connector Norman E. Shumway, MD, PhD: Visionary, innovator, humorist William A. Baumgartner, MD,a Bruce A. Reitz, MD,b Vincent L. Gott, MD,a and Sara J. Shumway, MDc Born in Kalamazoo, Michigan, in 1923, Norman Edward sent back into the infantry. He then did three quarters of Shumway, Jr, and his parents (Laura Vandervliet Shumway premed at Baylor University in Waco, Texas. and Norman Edward Shumway, Sr) moved to Jackson, When it was time for Dr Shumway to matriculate to med- Michigan, when he was 1 year of age. His parents’ business ical school, all of the military slots were filled. He took an was operating ‘‘The Home Dairy,’’ which consisted of the interim job at Western State Mental Institution in Memphis, dairy in the back section and a diner up front. He went to Tennessee, where he was an orderly for 6 months. A slot be- the local grade school and was influenced early in a potential came open at Vanderbilt University in 1945, where he career in medicine when one of his classmates died of appen- started medical school. At Vanderbilt he was influenced dicitis. At Jackson High School, Dr Shumway was active on by 2 prominent surgeons of the time: Dr Barney Brooks, the debate team. His team was highly successful and won the Chief of Surgery, and Dr Cobb Pilcher, Chief of Neurosur- Michigan state championship in his senior year and then gery.
    [Show full text]
  • Solid Organ Transplantation Basic Immunology Basic Immunology
    Basic Immunology Solid Organ Transplantation Daniel Maluf, MD Assistant Professor of Surgery VCU School of Medicine 1 2 Basic Immunology Basic Immunology 3 4 History of organ transplantation History of organ transplantation 1981 First successful heart-lung transplant 1954 First successful kidney transplant* Dr. Bruce Reitz, Stanford University Hospital, Stanford, CA Dr. Joseph E. Murray, Brigham & Women's Hospital, Boston, MA 1983 First successful single lung transplant* Dr. Joel Cooper, Toronto Lung Transplant Group, Toronto General 1966 First successful pancreas/kidney transplant Hospital, Toronto Canada Drs. Richard Lillehei, William Kelly, University of Minnesota, Minneapolis, MN 1986 First successful double lung transplant* Dr. Joel Cooper, Toronto Lung Transplant Group, Toronto General 1967 First successful liver transplant* Hospital, Toronto Canada Dr. Thomas Starzl, University of Colorado Health Sciences Center, 1989 First successful living-related liver transplant Denver, CO Dr. Christoph Broelsch, University of Chicago Medical Center, 1968 First isolated pancreas transplant Chicago, IL Dr. Richard Lillehei, University of Minnesota, Minneapolis, MN 1990 First successful living-related lung transplant Dr. Vaughn A. Starnes, Stanford University Medical Center, 1968 First successful heart transplant Stanford, CA Dr. Norman Shumway, Stanford University Hospital, Stanford, CA *Transplant was the first of its kind in the world 5 6 1 Cadaveric Donors, Cadaveric Transplants, Waiting List Additions 1994-2003: and Number on Waiting List U.S. 60,000 80,000 70,000 50,000 60,000 Waiting List at Year’s End 40,000 50,000 30,000 40,000 20,000 30,000 20,000 Transplants 10,000 Number of Registrations of Number 10,000 Donors 0 0 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 Year Kidney Liver Source: Donors from OPTN data as of 9/5/00; transplants from Scientific Registry data as of 9/5/00; snapshot of OPTN waiting list on the last day of each year.
    [Show full text]