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2014 FP 1-78:4-Color Section
FINAL PROGRAM 34th Annual Meeting and Scientific Sessions April 10 – 13, 2014 MANCHESTER GRAND HYATT SAN DIEGO International Society for Heart and Lung Transplantation Gilead is committed to expanding healthcare options for individuals living with cardiovascular and pulmonary diseases through innovative research, access, and education programs. © 2013 Gilead Sciences, Inc. All rights reserved. UNBP0009 March 2013 Gilead and the Gilead logo are trademarks of Gilead Sciences, Inc. INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION 34th ANNUAL MEETING and SCIENTIFIC SESSIONS April 10 – 13, 2014 TABLE OF CONTENTS About ISHLT 2 Board of Directors 4 Scientific Program Committee 6 Abstract Reviewers 8 Committees 17 Scientific Councils 25 Past Presidents 32 Daily Schedule Foldouts between 34-47 Award Recipients 35 Continuing Medical Education 46 Annual Meeting 49 Scientific Session Highlights Manchester Grand Hyatt Floor Plans 64 Annual Meeting 67 Schedule At a Glance Corporate Partners 78 Annual Meeting 79 Scientific Program and Schedule Exhibit Hall Floor Plan 278 List of Exhibitors 280 1 2 THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION (ISHLT) is a not-for-profit, multidisciplinary, professional organization dedicated to improving the care of patients with advanced heart or lung disease through transplantation, mechanical support and innovative therapies via research, educa- tion and advocacy. ISHLT was created in 1981 at a small gathering of The about 15 cardiologists and Purposes cardiac surgeons. Today we of the have over 2700 members from over 45 countries, rep- Society resenting over 15 different are: professional disciplines in- 1. To associate persons volved in the management interested in the fields of heart and treatment of end-stage and lung transplantation, end- heart and lung disease. -
Historical Perspectives of Lung Transplantation: Connecting the Dots
4531 Review Article Historical perspectives of lung transplantation: connecting the dots Tanmay S. Panchabhai1, Udit Chaddha2, Kenneth R. McCurry3, Ross M. Bremner1, Atul C. Mehta4 1Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA; 2Department of Pulmonary and Critical Care Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA; 3Department of Cardiothoracic Surgery, Sydell and Arnold Miller Family Heart and Vascular Institute; 4Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA Contributions: (I) Conception and design: TS Panchabhai, AC Mehta; (II) Administrative support: TS Panchabhai, RM Bremner, AC Mehta; (III) Provision of study materials or patients: TS Panchabhai, U Chaddha; (IV) Collection and assembly of data: TS Panchabhai, U Chaddha, AC Mehta; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Atul C. Mehta, MD, FCCP. Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA; Staff Physician, Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA. Email: [email protected]. Abstract: Lung transplantation is now a treatment option for many patients with end-stage lung disease. Now 55 years since the first human lung transplant, this is a good time to reflect upon the history of lung transplantation, to recognize major milestones in the field, and to learn from others’ unsuccessful transplant experiences. James Hardy was instrumental in developing experimental thoracic transplantation, performing the first human lung transplant in 1963. George Magovern and Adolph Yates carried out the second human lung transplant a few days later. -
HARBIN. NOVEMBER 2017. Sergio
POWER OVER LIFE AND DEATH Natalie Köhle ARBIN. NOVEMBER 2017. Sergio NESS is NOT in the BRAIN, which seeks HCanavero and Ren Xiaoping 任晓 to prove the existence of an eternal 平 announced that the world’s first hu- soul on the basis of near death experi- man head transplant was ‘imminent’. ence, as well as two guides on seducing They had just completed an eight- women. He also drops flippant refer- een-hour rehearsal on two human ca- ences to Stalin or the Nazi doctor Josef davers, and now claimed to be ready Mengele. for the real deal: the transplant of a human head from a living person with a degenerative disease onto a healthy, but brain-dead, donor body.1 Ren — a US-educated Chinese orthopaedic surgeon, was part of the team that performed the first hand transplant in Louisville in 1999. Canavero, an Italian, and former neu- rosurgeon at the university of Turin, is the more controversial, maverick per- sona of the team. In addition to many respected scientific publications, he Frankenstein’s Monster from The Bride of Frankenstein (1935) published Immortal: Why CONSCIOUS- Source: Commons Wikimedia 276 tor function and sensation. It would 277 also depend on the unproven capacity of the human brain to adjust to — and gain control over — a new body and a new nervous system without suffering debilitating pain or going mad.2 So far, Ren and Canavero have Sergio Canavero transplanted the heads of numerous Source: 诗凯 陆, Flickr lab mice and one monkey, and they Ren and Canavero see the head have also severed and subsequently Power over Life and Death Natalie Köhle transplant, formally known as cepha- mended the spinal cords of several POWER losomatic anastomosis, as the logical dogs. -
Lung Transplantation Adriaan Myburgh
Lung Transplantation Adriaan Myburgh ! UNIVERSITY OF CAPE TOWN ! Department of Anaesthesia and Perioperative Medicine ! ! ! ! ! ! ! Disclosure Jenna Lowe “ Get me to 21” • 4065 Donors Phalo - URE History • 1947: Vladimir Demikhov performs first successful animal lung transplantation • 1963: James Hardy performs first human lung transplantation in Jackson Mississippi 3 December 1967: First Human heart transplant Denise Darvall to Louis Washkansy • 1986: Joel Cooper performs first successful human double lung transplantation • 2001: Stig Steen performed first successful Non Heart Beating lung transplantation • 2007: Stig Steen performs first ex-vivo reconditioning human lung transplantation Recipients Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions Orens JB et al. J Heart Lung Transplant 2006; 25: 745-55 Contraindications ? Relative contraindications to lung transplantation • Age > 65 years • Critical or unstable condition (eg, shock, ECMO) • Severely limited functional status • Colonization with highly resistant bacteria, fungi or mycobacteria • Severe obesity (BMI > 30 kg/m2) • Severe osteoporosis • Mechanical ventilation • Other significant medical conditions ECMO Bridge-to-transplant Lung assist device (Novalung®) ECMO Strueber M. Curr Opin Organ -
The Morality of Head Transplant: Frankenstein’S Allegory
5 THE MORALITY OF HEAD TRANSPLANT: FRANKENSTEIN’S ALLEGORY Aníbal Monasterio Astobiza1 Abstract: In 1970 Robert J. White (1926-2010) tried to transplant the head of a Rhesus monkey into another monkey’s body. He was in- spired by the work of a Russian scientist, Vladimir Demikhov (1916- 1998), who had conducted similar experiments in dogs. Both Demikhov and White have been successful pioneers of organ transplantation, but their scientific attempts to transplant heads of mammals are often remem- bered as infamous. Both scientists encountered important difficulties in such experiments, including their incapacity to link the spinal cord, which ended up by creating quadriplegic animals. In 2013, neurosurgeon Sergio Canavero claimed his capacity and plan to carry out the first human head 1 I am grateful to the Basque Government sponsorship for carrying out a posdoc- toral research fellowship at the Uehiro Centre for Practical Ethics of the University of Oxford, and to the latter institution for its warm welcome. Also, I would like to thank David Rodríguez-Arias for his invaluable comments and suggestions for the improvement of this paper. As usual, any error is solely the author’s responsibility. This work was carried out within the framework of the following research projects: KONTUZ!: “Responsabilidad causal de la comisión por omisión: Una dilucidadión ético-jurídica de los problemas de la acción indebida” (MINECO FFI2014-53926-R); “La constitución del sujeto en la interacción social: identidad, normas y sentido de la acción desde la perspectiva de la filosofía de la acción, la epistemología y la filosofía experimental” (FFI2015-67569-C2-2-P), and “Artificial Intelligence and Biotechnol- ogy of Moral Enhancement Ethical Aspects” (FFI2016-79000-P). -
A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised
MESTRADO INTEGRADO MEDICINA A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program Revised Maria Inês dos Reis Rodrigues M 2019 A Contemporary Review of Adult Lung Transplantation and the Portuguese Lung Transplant Program revised Maria Inês dos Reis Magalhães Rodrigues I [email protected] Mestrado Integrado em Medicina Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Orientador: Professor Doutor Humberto José da Silva Machado Professor Associado Convidado do Instituto de Ciências Biomédicas Abel Salazar Assistente Hospitalar Graduado Sénior de Anestesiologia do Centro Hospitalar do Porto Diretor do Serviço de Anestesiologia do Centro Hospitalar do Porto Adjunto da Direção Clínica do Centro Hospitalar do Porto Maio 2019 24 de maio de 2019 Agradecimentos Ao Professor Doutor Humberto Machado pela orientação, disponibilidade, interesse e apoio que sempre demonstrou, indispensáveis para a realização do presente trabalho. Aos meus pais e irmã, pelos valores transmitidos e por toda a ajuda e companheirismo ao longo do meu percurso de vida. i Resumo Introdução: O transplante pulmonar é atualmente uma opção terapêutica para doentes com doença pulmonar terminal. Nos últimos 30 anos verificou-se um constante crescimento na área da transplantação pulmonar e, com o desenvolvimento de novos fármacos imunossupressores e o aperfeiçoamento de técnicas cirúrgicas e de conservação de órgãos, houve um aumento da sobrevivência e da qualidade de vida dos doentes transplantados. Em Portugal, o programa de transplantação pulmonar teve início em 2001 no Hospital Santa Marta, Centro Hospitalar de Lisboa Central. Apesar de ser o único centro de transplantação pulmonar do país, um número crescente de transplantes pulmonares tem vindo a ser realizado, passando de 8 transplantes realizados em 2009 para 34 transplantes realizados em 2017. -
Alternative Therapies for Orthotopic Heart Transplantation
Alternative Therapies for Orthotopic Heart Transplantation Daniel J. Garry, M.D., Ph.D. Medical Grand Rounds, Department of Internal Medicine July 19, 2001 Disclosure: This is to acknowledge that Daniel Garry, M.D., Ph.D. has not disclosed any financial interests or other relationships with commercial concerns related directly or indirectly to this program. Dr. Garry will be discussing off-label uses in his presentation. BIOGRAPHICAL INFORMATION: Daniel J. Garry, M.D., Ph.D. Assistant Professor, Departments of Internal Medicine, Molecular Biology UT Southwestern Medical Center INTERESTS: Congestive Heart Failure/Cardiac Transplantation Basic science mechanisms·of stem cell biology & oxygen metabolism 2 Congestive heart failure (CHF) Therapeutic strategies for heart failure have evolved tremendously over the past several hundred years. Treatment of congestive heart failure (CHF) or what was referred to as "dropsy" was aimed initially at restoring a balance of fundamental elements and humors. In 1683, Thomas Sydenham recommended bleeding, purges, blistering, garlic and wine. Additional treatments were attempted and abandoned after unrewarding anecdotal experiences (i.e. death). Progress regarding the treatment of heart failure was evident with the introduction of amyl nitrate, mercurial diuretics, digitalis glycosides and bed rest in the early 20th century. Medical therapy for heart failure in the 1960's included digitalis, thiazide diuretics (introduced in 1962) and furosemide (introduced in 1965). The utilization of vasodilators for heart failure were implemented in the 1970's (nitroprusside in 1974 and hydralazine in 1977) and the first large, randomized, clinical trial for heart failure was not completed until 1986 (V-HeFf 1). Since then, the design and completion of a number of large, randomized, placebo-controlled clinical trials have established angiotensin-converting enzyme inhibitors and B-adrenergic receptor antagonists as the cornerstones of therapy. -
Lung Transplantation in the Third Millennium Third the in Lung Transplantation in the Third Millennium
AME Medical Book 1A025 1A025 Lung Transplantation in the Third Millennium Transplantation Lung in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta www.amegroups.com Editors: Federico Venuta Raemdonck Dirk Van Lung Transplantation in the Third Millennium Editors: Dirk Van Raemdonck Federico Venuta AME Publishing Company Room C 16F, Kings Wing Plaza 1, NO. 3 on Kwan Street, Shatin, NT, Hong Kong Information on this title: www.amegroups.com For more information, contact [email protected] Copyright © AME Publishing Company. All rights reserved. This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of AME Publishing Company. First published in 2018 Printed in China by AME Publishing Company Editors: Dirk Van Raemdonck, Federico Venuta Lung Transplantation in the Third Millennium (Hard Cover) ISBN: 978-988-77840-4-3 AME Publishing Company, Hong Kong AME Publishing Company has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. The advice and opinions expressed in this book are solely those of the authors and do not necessarily represent the views or practices of the publisher. No representation is made by the publisher about the suitability of the information contained in this book, and there is no consent, endorsement or recommendation provided by the publisher, express or implied, with regard to its contents. I LUNG TRANSPLANTATION IN THE THIRD MILLENNIUM (FIRST EDITION) EDITORS Greg L. -
Newsletteralumni News of the Newyork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009
NEWSLETTERAlumni News of the NewYork-Presbyterian Hospital/Columbia University Department of Surgery Volume 12 Number 1 Spring 2009 Outliers All requires several iterative improvements and sometimes a leap of faith to cross a chasm of doubt and disappointment. This process is far more comfortable and promising if it is imbued with cross- discipline participation and basic science collaboration. Eric’s early incorporation of internist Ann Marie Schmidt’s basic science group within his Department continues to be a great example of the pro- ductivity that accrues from multidiscipline melding. Several speakers explored training in and acceptance of new techniques. The private practice community led the way in training and early adoption of laparoscopic cholecystectomy, which rapidly supplanted the open operation, despite an early unacceptable inci- dence of bile duct injuries. Mini-thoracotomies arose simultaneous- ly at multiple sites and are now well accepted as viable approaches to the coronaries and interior of the heart; whereas, more than a de- cade after their introduction, video assisted lobectomies for stage I, non-small-cell lung cancer account for <10% of US lobectomies. Os- tensibly, this reluctance reflects fear of uncontrollable bleeding and not doing an adequate cancer operation, neither of which has been a problem in the hands of VATS advocates. The May 8, 2009, 9th John Jones Surgical Day was a bit of an Lesions that are generally refractory to surgical treatment, outlier because the entire day was taken up by a single program, ex- such as glioblastomas and esophageal and pancreas cancers merit cept for a short business meeting and a lovely evening dinner party. -
Organ Transplantation a Clinical Guide
Organ Transplantation A Clinical Guide Organ Transplantation A Clinical Guide Edited by Andrew A. Klein Consultant, Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK Clive J. Lewis Consultant Cardiologist and Transplant Physician, Papworth Hospital, Cambridge, UK JorenC.Madsen Director of the MGH Transplant Center, Section Chief for Cardiac Surgery, and W. Gerald and Patricia R. Austen Distinguished Scholar in Cardiac Surgery, Massachusetts General Hospital, Boston, MA, USA CAMBRIDGE UNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, Sao˜ Paulo, Delhi, Tokyo, Mexico City Cambridge University Press The Edinburg Building, Cambridge CB2 8RU, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521197533 c Cambridge University Press 2011 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2011 Printed in the United Kingdom at the University Press, Cambridge A catalogue record for this publication is available from the British Library. Library of Congress Cataloguing in Publication data Organ transplantation : a clinical guide / edited by Andrew Klein, Clive J. Lewis, Joren C. Madsen. p. ; cm. Includes bibliographical references and index. ISBN 978-0-521-19753-3 (hardback) 1. Transplantation of organs, tissues, etc. 2. Transplantation immunology. I. Klein, Andrew. II. Lewis, Clive J., 1968– III. Madsen, Joren C., 1955– [DNLM: 1. Organ Transplantation. 2. Transplantation Immunology. WO 660] RD120.7.O717 2011 617.95 – dc22 2011002165 ISBN 978-0-521-19753-3 Hardback Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. -
Surgical Neurology International James I
OPEN ACCESS Editor: Surgical Neurology International James I. Ausman, MD, PhD For entire Editorial Board visit : University of California, Los http://www.surgicalneurologyint.com Angeles, CA, USA Letter to the Editor Ethical considerations regarding head transplantation Anto Čartolovni, Antonio G. Spagnolo Università Cattolica del S. Cuore (Catholic University of the Sacred Heart), "A. Gemelli" School of Medicine, Institute of Bioethics, 1, Largo Francesco Vito, I-00168 Rome, Italy E-mail: *Anto Čartolovni - [email protected]; Antonio G. Spagnolo - [email protected] *Corresponding author Received: 25 March 15 Accepted: 05 May 15 Published: 15 June 15 This article may be cited as: Cartolovni A, Spagnolo AG. Ethical considerations regarding head transplantation. Surg Neurol Int 2015;6:103. Available FREE in open access from: http://www.surgicalneurologyint.com/text.asp?2015/6/1/103/158785 Copyright: © 2015 Čartolovni A. This is an open‑access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Dear Editor, procedure but one for prolonging life, that could even play an essential role in the decision to accept it. Even if We read with interest and some perplexity the article the procedure is accepted in years to come, the subject by the Italian surgeon, Sergio Canavero, on the will be exposed to far greater and unknown risks than the subject of head transplantation commonly known as benefits of the procedure. First of all, assuming that the HEAVEN surgery shorthand for its more full name, spinal cord connection succeeds, the patient will need to “head anastomosis venture” and GEMINI spinal cord take a large amount of immunosupressive drugs and it fusion (SCF) procedure.[2] We find it essential to address is not even clear if the rejection problem will be solved some crucial ethical questions that might even clarify the by taking such drugs. -
Taylor 52 1..6
Published: 12 May 2015 © 2015 Faculty of 1000 Ltd Advances in the understanding and management of heart transplantation Dhssraj Singh and David O. Taylor* Address: Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA * Corresponding author: David O. Taylor ([email protected]) F1000Prime Reports 2015, 7:52 (doi:10.12703/P7-52) All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/legalcode), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The electronic version of this article is the complete one and can be found at: http://f1000.com/prime/reports/m/7/52 Abstract Cardiac transplantation represents one of the great triumphs in modern medicine and remains the cornerstone in the treatment of advanced heart failure. In this review, we contextualize pivotal developments in our understanding and management of cardiac transplant immunology, histopathology, rejection surveillance, drug development and surgery. We also discuss current limitations in their application and the impact of the left ventricular assist devices in bridging this gap. Introduction cardiac transplantation was only 29 days. Within 1 year, As we approach 2017, the 50th anniversary of the first all but 3 of the 50 early-adopting institutions shut down heart transplant, cardiac transplantation remains the their heart transplant programs. One year survival rates gold standard in the treatment of end-stage heart failure in the early days were hampered by allograft rejection. and represents one of the great triumphs of modern The initial immunosuppression regimen consisted of medicine.