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Click here for an analysis of the past 50 years of Prix Galien awards

MEDIA KIT 2O21 prix galien usa NEW YORK CITY, OCTOBER 28, 2021 PRE-EVENT & ON-SITE RESOURCES FOR JOURNALISTS

Galien Foundation events are conducted fully on the record, and we welcome and invite members of the media to participate as engaged stakeholders via onsite discussion, as well as via social media, and to report on proceedings and outcomes. MISSION We certainly appreciate coverage of our events, but our priority is to help you explore and uncover today’s key issues and connect The Prix Galien Award recognizes outstanding achievements with the people and diverse organizations we bring together that in improving the global human condition through the make the world a healthier place. development of innovative drugs and other treatments. To help facilitate your engagement with our speakers and The Prix Galien was created in 1970 in honor of Galien, stakeholders, we are delighted to work with you in the lead-up the father of medical science and modern pharmacology. to our 2021 Forum and Ceremony on: Worldwide the Prix Galien is regarded as the equivalent of the Nobel Prize in biopharmaceutical research. • Arranging interviews with key speakers and stakeholders

• Reserving private spaces for on-site interviews The Prix Galien is more than an award: it is a movement with a mandate to foster, recognize and reward excellence in scientific • Sharing our latest programs and speaker lists innovation to improve the state of human health. Building on an unrivaled network of top biomedical scientists including Nobel • Providing hi-resolutions imagery (including photos Laureates in medicine, the Prix Galien manages an independent, of people, spaces, logos, etc.) cross-functional and geographically diverse program of events and sponsorships to brand “the best of the best” in new KEEP IN TOUCH medicines and diagnostics. Our scope is global, and our commitment to progress in medicine is both measurable and concrete. Our members express this Stay up to date on the latest announcements, events and through the establishment of productive relationships to build happenings from the Galien Foundation’s newsletter lasting bridges between the commercial research enterprise (www.galienfoundation.org/index.php/2018/08/16/contact-2/) and local communities engaged in public policy, science, finance, academic research and the media. FOR MORE INFORMATION AND TO REGISTER In addition to recognizing advances in promising therapies, the FOR A PRESS PASS PLEASE CONTACT: Prix Galien’s annual Roy Vagelos Pro Bono Humanum Award for humanitarian achievements (www.galienfoundation.org/ index.php/2017/01/31/probono) brings a unique focus to the FINN PARTNERS intersection between science, business and politics. The outcome Holmes Report & PR News / Midsize Agency of the Year we seek is guided by the synthesis principle that underpins the CONTACT: conduct of science itself: successful innovation where financing, physical assets, knowledge and skills are combined from many • Kara Bradley, Account Supervisor sources to move new ideas quickly “from the bench to the T: +1 646 213 7243 - [email protected] bedside,” on behalf of patients everywhere. • Kelly Czochanski, Account Executive T: +1 646 213 7245 - [email protected] A truly global program present in 15 countries* HELPFUL LINKS : www.galienfoundation.org Our program includes a review of contributions from a new generation of innovators representing diverse sectors in health. • Prix Galien USA Our mission is to advance cross-cultural contacts and harmonize • Forum (latest programs, participants, registration regulation, internal business processes, new information and reports) technologies and public-private partnerships to remove barriers to the commercialization of good medicines and expand across to • Pro Bono Humanum Award these benefits to all who need them. • Med StartUp Award • Prix Galien Around the Globe • Prix Galien Hall of Fame This hyperlinked analysis of the past 50 years of Prix Galien awards innovation to improve the human condition

Sue Desmond-Hellmann, Ethiopia Clinic site visit

th 2021 : Prix Galien’s 50 Anniversary Our diverse geographic reach is evident with the International Africa Now! Senegal, Africa Selected As Permanent Host Prix Galien Awards, which launched in 1990, and is conducted for The International Prix Galien Awards Ceremony and every two years to highlight the "best of the best" in research that Launch of the Prix Galien Africa. brings dividends to patients across geographies with differing health needs. This desire to make biopharmaceutical and med The Prix Galien Golden Jubilee : 2021 is a landmark year tech innovation a global endeavor, bringing progress to patients celebrating 50 years of progress in recognizing excellence in in all corners of the world, will now be a key priority for the Prix biopharmaceutical and med tech innovations to improve the Galien community going forward. human condition. Under the sponsorship of the government of Senegal and the As a special feature, our 50th Golden Jubilee year will honor WHO Regional Office for Africa, the Prix Galien Africa is our the “global best of the very best” in: A- Pharmaceutical; first truly region-wide initiative. It stands as a living tribute to B- Biotechnology; C- Orphan and Rare diseases; D- Vaccines; and the vision of Foundation co-founder, 1986 Nobel peace laureate E- Medical technology products. Eligibility will be drawn from the Elie Wiesel, who believed in medical innovation not only as an 250 products awarded the Prix Galien by our 14 member-country industrial policy asset but as a source of social progress, where chapters since 1970, developed by more than 80 innovative private enterprise and public engagement combine to deliver a companies, most of whom continue to bring new therapies for greater public good – health equity and access for all. today’s patients with unmet medical needs. We invite all communities with a commitment The Galien Forum and Prix Galien USA Ceremony will take place to the conduct and promotion of life sciences on October 28 in New York City at the Alexandria Center for Life innovation to contribute to this important work. Science and Museum of Natural History, respectively. During the Ceremony, we will also announce the short list for the “Awards of the Jubilee” – which will be selected by all past and present Committee members across the globe. CONTENT The Golden Jubilee awards will be announced on December 11, 2021 in Dakar in the presence of the President of the Senegalese Republic, H.E. Macky Sall, alongside many African heads of state PRIX GALIEN USA FOUNDING COMMITTEE ...... 4 and ministers of health and/or environment, the WHO Director- 2021 AWARDS COMMITTEE ...... 5 General as well as hundreds of scientists and industry and innovation leaders. GALIEN FORUM ...... 6 Overview & Background The best locale to pursue our mission is the African continent, “They participated in the Forum” whose young population is destined to double to 2.5 billion people by 2050. According to the World Economic Forum, early-stage TESTIMONIALS FROM AROUND THE GLOBE...... 8 entrepreneurial activity is nearly 15% higher in Africa than the HALL OF FAME global average – yet while the continent is today home to 11% of HISTORY OF THE PRIZE AND MEDAL...... 10 the world’s population, it accounts for a mere 1% of total health spending and carries a crippling 25% of the global disease PRIX GALIEN USA ...... 11 burden. Taken together, these statistics reveal the progress THE ROY VAGELOS PRO BONO HUMANUM AWARD...... 12 inherent in what a few years will be the world’s youngest and potentially most productive population, but whose prospects WHO WAS GALEN ...... 13 depend on more investment in health care as the key driver of PRIX GALIEN MEDSTART UP ...... 14 development. PRIX GALIEN USA WINNERS ...... 15

* Africa, Belgium, Canada, , France, Germany, Greece, Italy, Netherlands, Poland, Russia, Spain, Switzerland, United Kingdom and the United States. “ Thanks to their gifts to society and their determination to alleviate and cure its woes, the scientists deserve to be ranked among prix galien usa the true friends of the human race.”

Elie WIESEL In Memoriam FOUNDING Honorary Founding President The Galien Foundation COMMITTEE Peace Nobel Laureate 2OO7-2O1 1 Boston University

Michael S. BROWN, MD Barry S. COLLER, MD Walter GILBERT, PhD Joseph GOLDSTEIN, MD Nobel Laureate Vice President for Nobel Laureate Nobel Laureate Professor of Molecular Medical Affairs Professor Emeritus Professor of Molecular Genetics and Internal and Physician-in-Chief, Harvard University Genetics and Internal Medicine Rockefeller University Medicine UT Southwestern UT, Southwestern Medical Center at Dallas Medical Center at Dallas

Paul GREENGARD, PhD Eric R. KANDEL, MD Joshua LEDERBERG, Richard A. LERNER, MD Nobel Laureate Nobel Laureate MD, PhD Professor of Professor of Molecular Professor of physiology Nobel Laureate Immunochemistry, Chair and Cellular Neuroscience and Cellular Biophysics Professor Emeritus, in Chemistry Rockefeller University Columbia University Laboratory of Molecular Scripps Research Institute Genetics and Informatics, Rockefeller University

Paul A. MARKS, MD Bengt SAMUELSSON, Jan T. VILCEK, MD Gerald WEISSMANN, MD Laboratory Head of Cell Biology MD, PhD Professor of Microbiology Professor of Rheumatology Memorial Sloan Kettering Nobel Laureate New York University School and Director of Cancer Center Professor of Medicine Biotechnology Study Center Karolinska Institutet; New York University School Former President of Medicine Karolinska Institutet; Former Chairman Nobel Foundation 4 prix galien usa Susan DESMOND-HELLMANN, MD, MPh COMMITTEE Committee Chair Former Chief Executive Officer 2O21 Bill & Melinda Gates Foundation

Pr Elie WIESEL Peace Nobel Laureate, Boston University. Honorary Founding President In Memoriam The Galien Foundation Richard AXEL, MD Linda B. BUCK, PhD Laurie GLIMCHER, MD Nobel Laureate Nobel Laureate President and CEO Dana Farber Co-director The Kavli Institute Fred Hutchinson Cancer Cancer Institute; for Brain Science, Research Center member, Professor of Medicine Columbia University and Professor of Physiology Harvard Medical School Medical Center and Biophysics University of Washington

Mary-Claire KING, PhD Robert S. LANGER Cato T. LAURENCIN, MD, PhD American Cancer Society David H. Koch Institute University Professor Professor of Genome Professor University of Connecticut Sciences and Medical Genetics Massachusetts Institute P. Roy VAGELOS University of Washington of Techonology Committee Chair 2012-2017

Retired Chairman and CEO, Merck & Co., Inc. Chairman of the Board, Regeneron Pharmaceuticals, Inc.

Steven LESTER, MD Michael ROSENBLATT, MD Bengt SAMUELSSON, MD, Ph Chief Medical Officer Chief Medical Officer Nobel Laureate Mayo Clinic-ASU Flagship Pioneering Professor Karolinska Institutet; MedTech Accelerator Former President Karolinska Institutet; Former Chairman Nobel Foundation

Marc TESSIER-LAVIGNE, PhD Tachi YAMADA, MD President Venture Partner Stanford University Frazier Healthcare Partners 5 PRIX GALIEN DIGITAL HEALTH CATEGORY Chairman: Bernard POUSSOT Director, Roche Holding, Former Chairman & CEO, WYETH THE JURY Roch DOLIVEUX Mikael DOLSTEN Jean-Pierre GARNIER Honorary CEO, Global R&D President, Former CEO, UCB Pfizer GSK Submit your product to the 2021 Prix Galien USA Robin Welbers: 917 781 0521 - [email protected] Penny HEATON Franz HUMER CEO - Bill & Melinda Gates Former Chairman & CEO, http://candidates.prix-galien-usa.com/submissions/home Medical Research Institute Roche

Sheri McCOY François MAISONROUGE Elias ZERHOUNI Board of Directors, AstraZeneca Senior Managing Director, Former Head of Global R&D, Chair of the Board, Certara Evercore Partners Sanofi

DIGITAL ADVISORY BOARD Junaid BAJWA, MD

Prix Galien Chief Medical Scientist, Microsoft Research

Company Name Title Photo DIGITAL ADVISORY BOARD Lisa Abbott Executive VP - Earnhardt Digital HealthMedical Device CompanyLisa EARNHARDTName Title Photo Abbott Lisa Executive VP - The Emmanuel MD, MBA, is a Earnhardt Future of Fombu physician, author,Executive ViceMedical President, Device Medical Device, Abbott Healthcare speaker and

healthcare The Emmanuel MD, MBA, is a executive turned ADVISORY Future of Fombu physician, author, Silicon Valley Emmanuel FOMBU, MD, MBA Healthcare speaker and entrepreneur

healthcare AbbVie Francisco Physician, Director, Digital Author, Speaker and healthcare executive turned Silicon Valley entrepreneur executive turned Rausa Health & AbbVie Francisco Director, Digital Silicon Valley entrepreneur TheInnovation Future of Healthcare

BOARDRausa Health & General Partner at Qualcomm Thomas dRx Capital, Head of Kluz Innovation Global Healthcare Investing, Qualcomm Thomas KLUZ

Ventures Qualcomm Thomas General Partner at Jian Yang dRx Capital, Head of Eli Lilly MD, Sr. Director,General Partner at dRx Capital, Head of Global Healthcare Investing, Qualcomm Ventures Kluz Global Healthcare Digital Health Investing, Qualcomm Ventures DIGITAL ADVISORY BOARD Sachin NANAVATI

Jian Yang Eli Lilly MD, Sr. Director, Oracle Steven Former Senior Vice Head of Industry, Healthcare. Google President of Oracle Rosenberg Company Name Title Photo Health Sciences and Digital Health Abbott Lisa Executive VP - General Manager of The Emmanuel MD, MBA, is a Oracle Health Earnhardt Former Senior Vice Medical DeviceFuture of Fombu physician, author, Oracle Steven Sciences Shez Partovi President of Oracle Amazon MD, Worldwide Rosenberg Healthcare speaker and Health Sciences and Lead: Healthcare, Shezhealthcare PARTOVI, MD General Manager of Life Sciences, executive turned Oracle Health Silicon Valley Sciences Genomics, Chief Innovation & Strategy Officer, Philips Medical Devices, entrepreneur Agriculture |

Amazon Web AbbVie Francisco Director, Digital Services Rausa Health &

General Partner Franciscoat RAUSA Innovation Qualcomm Thomas dRx Capital, Head of Kluz GlobalDIGITAL Healthcare ADVISORYDirector, BOARD Digital Health & Innovation, AbbVie Investing, Qualcomm Shez Partovi Ventures Amazon MD, Worldwide Company Name Title Photo Abbott Lisa Executive VP - Lead: Healthcare, Earnhardt MedicalMaryAnne Device Rizk, PhD Life Sciences, Eli Lilly Jian Yang MD, Sr. Director, Genomics, Digital Health CEO Rizk Management Consulting

Medical Devices, Oracle Steven FormerAbbVie Senior ViceFrancisco Director, Digital President of Oracle Agriculture | Rosenberg Rausa Health & Steven ROSENBERG Health Sciences and Innovation Amazon Web General Manager of Oracle Health Former Senior Vice President of Oracle Health Sciences Services Sciences and General Manager of Oracle Health Sciences

Eli Lilly Jian Yang MD, Sr. Director, Digital Health Amazon Shez Partovi MD, Worldwide Jian YANG, MD Lead: Healthcare, Life Sciences, Senior Director, Digital Health, Eli Lilly Genomics, Medical Devices, Agriculture | Shez Partovi Amazon Web Amazon MD, Worldwide Lead: Healthcare, Services Life Sciences, Genomics, PRIX GALIEN MEDSTARTUP Medical Devices, Agriculture | Amazon Web Continuous innovation is one of the Biopharmaceutical industry’s most definingServices characteristics.

New medications can be crucial for maintaining the quality of human life. In 2014, The Galien Fondation, and Business France have launched To date, the Galien Medstartup Awards has supported companies Galien Medstartup Awards, with an independent Selection Committee to raise $300 million in funds and given rise to 125 transatlantic chaired by Bernard Poussot, former CEO and President of Wyeth and partnerships that grew out of Prix Galien Medstartup leads. currently Board of Directors of Roche Holding. The mission of the The Prix Galien Medstartup USA nominates nominees in three categories: Galien Medstartup Awards is to be the catalyst for the development of the next generation of innovative treatment and technologies that will A- Best Collaboration in the Pharmaceutical & Biotechnology industrie; impact human health and save lives. The Galien Medstartup Awards B- Best Collaboration in the Medtech & Digital Health industries; and fosters private-sector collaborations with the focal point of including the most innovative start-up companies. It aims at strengthening C- Best Collaboration dedicated to the developing or underserved scientific and commercial partnerships that bridge the traditional silos populations worldwide. Winners are announced during the Forum between government, industry, and academia; defraying the growing Galien USA, which takes place at in New York in October of each year. complexity and cost burden of medicines R&D; and promoting cross- border trade, jobs, and economic growth. JOIN US ON : 6 http://medstartup.galienfoundation.org + PRIX GALIEN USA WINNERS AND IN 2O21, THE WINNERS ARE…

Digital Galien Week of InnovatioN October 25, 26, 27, 2021 Around 20 webinars covering the therapeutics areas of the 2021 Prix Galien USA Nominees that will include one spokesperson for each Nominee

Submit your product to the 2021 Prix Galien USA

Robin Welbers: 917 781 0521 - [email protected] http://candidates.prix-galien-usa.com/submissions/home 2O20 Click here for an analysis of the • Best Pharmaceutical Product: Pretomanid, TB Alliance past 50 years of Prix Galien awards Elias ZERHOUNI • Best Biotechnology Product: Tegsedi®, Akcea Therapeutics and Ionis Pharmaceuticals Former Head of Global R&D, ONPATTRO®, Alnylam Pharmaceuticals Sanofi VYNDAQEL®, Pfizer Inc. • Best Medical Technology: Abbott’s MitraClip™ Transcatheter Mitral Valve Repair System, Abbott • Best Digital Health Product: SOMRYST, Pear Therapeutics • Pro Bono Humanum Award: Dr William H. Foege 2O19 2O18 • Best Pharmaceutical Product: SHINGRIX, GlaxoSmithKline • Best Pharmaceutical Product: IDHIFA®, Celgene Agios • Best Biotechnology Product: LUXTURNA™, Spark Therapeutics • Best Biotechnology Product: Yescarta®, Kite, a Gilead Company • Best Medical Technology: FreeStyle® Libre 14 Day Flash & Kymriah®, Novartis Pharmaceuticals Corporation Glucose Monitoring System, Abbott • Best Medical Technology: WATCHMANTM, Boston Scientific Corporation • Pro Bono Humanum Award: Jim and Marilyn Simons, • Pro Bono Humanum Award: Bill and Melinda Gates. The Simons Foundation Co-Chairs, Bill & Melinda Gates Foundation

2O17 2O16 2O15 Discovery • Best Pharmaceutical Product: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: of the Decade Venclexta™, AbbVie & Genentech Ibrance®, Pfizer, Inc. IMBRUVICA®, Janssen Biotech, • Best Pharmaceutical Agent: ® (a Member of the Roche Group) • Best Biotechnology Product: Inc. & Pharmacyclics LLC, Gleevec , Novartis Shez PARTOVI, MD • Best Biotechnology Product: Cosentyx®, Novartis an AbbVie Company • Best Biotechnology Product: Chief Innovation & Strategy Officer, Philips ® ® SPINRAZA , Biogen & Ionis • Best Medical Technology: • Best Biotechnology Product: Yervoy , Bristol-Myers Squibb ® Pharmaceuticals Cologuard®, Exact Sciences OPDIVO , Bristol-Myers Squibb • Best Medical Technology: ® Francisco RAUSA • Best Medical Technology: KEYTRUDA , Merck & Co., Inc. Sapien 3TM, Edwards Lifesciences Director, Digital Health & Innovation, AbbVie Exablate Neuro, INSIGHTEC • Best Medical Technology: • Pro Bono Humanum Award: • Pro Bono Humanum Award: T2Candida Panel, T2 Biosystems, Inc. Paula S. Apsell Former President Jimmy Carter • Pro Bono Humanum Award: Pr Mary-Claire King Steven ROSENBERG Former Senior Vice President of Oracle Health Sciences 2O14 2O13 2O12 2O11 and General Manager of Oracle Health Sciences • Best Pharmaceutical Agent: • Best Pharmaceutical Agents: • Best Pharmaceutical Agents: • Best Pharmaceutical Agent: Sovaldi® - Gilead Sciences Zelboraf® - Genentech Victrelis® - Merck & Co., Inc.; Prevnar13® - Pfizer ® • Best Biotechnology Product: • Best Biotechnology Product: Incivek - Vertex Pharmaceuticals • Best Biotechnology Product: HEMACORD® - The New York Zostavax® - Merck & Co., Inc. • Best Biotechnology Product: Stelara® - Janssen ® ® Blood Center’s Howard • Best Medical Technology product: Yervoy - Bristol-Myers Squibb Prolia and XGEVA - Amgen P. Milstein Cord Blood Center S-ICD® System - Boston Scientific • Best Medical Technology product: • Pro Bono Humanum Award: ® • Best Medical Technology: • Pro Bono Humanum Award: Sapien -Edwards Lifesciences Paul Farmer ® ® Trevo ProVue - Stryker Dr Anthony S. Fauci Melody -Medtronic • Pro Bono Humanum Award: • Pro Bono Humanum Award: Dr Bernard Kouchner Dr Francis S. Collins

2O1O 2OO9 2OO8 2OO7 • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: • Best Pharmaceutical Agent: Coartem® - Novartis Gleevec® - Novartis Isentress® - Merck & Co., Inc.; Januvia® - Merck & Co., Inc.; ® ® • Best Biotechnology Product: • Best Biotechnology Product: Selzentry - Pfizer Chantix - Pfizer RotaTeq® - Merck & Co., Inc. Nplate® - Amgen; • Best Biotechnology Product: • Best Biotechnology Product: ® ® ® ® • Best Medical Technology: Promacta - GlaxoSmithKline Soliris - Alexion; Infuse - Wyeth Humira - Abbott; ® xTAG® - Luminex Corporation • Best Medical Technology: • Special therapeutic development: Gardasil - Merck & Co., Inc. ® ® • Pro Bono Humanum Award: Cellsearch - Veridex (J&J) Revlimid - Celgene • Pro Bono Humanum Award: Bill Clinton and • Pro Bono Humanum Award: • Pro Bono Humanum Award: Dr Roy Vagelos Philippe Douste-Blazy Jeffrey Sachs and Barry Bloom Sheldon Segal 7 PRIX GALIEN A RECORD OF LEADERSHIP IN BRINGING THE BEST OF BIOMEDICAL DISCOVERY TO THE ATTENTION OF THE WORLD

“I know the importance of the Prix Galien “The Prix Galien since 1970 is dedicated which rewards every year therapeutic to promoting the research innovations and research works among and development of the medicine the most creative.“ and medicine industries.“ Emmanuel Macron Macky Sall “I’d also like to congratulate all the French President - 2018 Senegalese President - 2018 candidates for the 5th Annual Prix Galien Awards Competition, which honors those in the pharmaceutical industry who have developed the technical, scientific and clinical research skills necessary to develop innovative medicines and devices. Your work is invaluable.“ Margaret A. Hamburg, M.D. Commissioner of Food and Drugs US Food and Drug Administration - 2011

“I applaud Prix Galien for recognizing “We recognize the importance of the the pioneering spirit of America Prix Galien in promoting drug research, innovation and research.“ and we salute the excellent work of the Jury.“ John McCain American Senator - 2008 Philippe Douste-Blazy French Minister of Foreign Affairs – 2006

“When Olympic rhymes with Galenic: there is a gold medal that can be won for an extraordinary achievement: this is the Galien Award, the Oscar of pharmaceutical research.“ Walter Sutter “The Prix Galien is a prestigious award, Swiss State Advisor, Director “The Galien Foundation, created to honor a magnificent occasion to pay of the Public Economy - 2004 and catalyze excellence in scientific recognition to our researchers and innovation, recognizes outstanding to encourage our industry.“ achievement with the prestigious Prix Galien Award.“ Jean Chretien Canadian Prime Minister - 1994 Bill De Blasio Mayor of the City of New York - 2015 8 PRIX GALIEN A RECORD OF LEADERSHIP IN BRINGING THE BEST OF BIOMEDICAL DISCOVERY TO THE ATTENTION OF THE WORLD

“I welcome you to the annual Prix Galien awards for innovative excellence in biomedical products and health “The Prix Galien is a welcome technologies. The awards are among “I am particularly grateful initiative to stimulate creative the highest honors in science and to receive this Award.“ research and promote excellence.“ commerce..“ Bill Clinton Barack Obama Jimmy Carter American President - 2010 American President - 2008 American President - 2017

“I look forward to the day when we will celebrate an African winner “The Prix Galien USA recognizes the of the Prix Galien.“ “The Prix Galien Awards are a true important research necessary to develop celebration of the years of hard work innovative medicines and devices that Tedros Adhanom Ghebreyesus that are required to produce lifechanging have a life-saving impact on individuals Director-General, interventions.“ World Health Organization - 2018 and families across the globe.“ Bill & Melinda Gates - 2018 Kathleen Sebelius American Secretary of Health and Human Services - 2011

“The Prix Galien is the right event, on the right issue at the right time. I thank the Galien Foundation for bringing us together and for recognizing that “Prix Galien recognizes men and women “It is a pleasure to congratulate all those who a healthier world is a safer world and from the pharmaceutical and biomedical promote the Prix Galien and pharmaceutical a more just world.“ industries whose contributions of research: they play a vital role in the fight BAN Ki-moon science have improved and saved against disease throughout the world.“ UN Secretary-General - 2010 countless lives.“ John Major Michael Bloomberg British Prime Minister - 1996 Mayor of the City of New York - 2010 9 PRIX GALIEN Hall of Fame Around the globe since 1970

BY NUMBER OF MEDALS

Click here for an analysis of the past 50 years of Prix Galien awards

COMPANY MEDALS COMPANY MEDALS COMPANY MEDALS MERCK&CO 64 CHUGAI PHARMA 2 GUERBET 1 NOVARTIS 57 CTRS 2 INSIGHTEC 1 ROCHE 50 EDWARDS LIFESCIENCES 2 INSTITUT STUCHU 1 GSK 40 FRESENIUS BIOTECH 2 INTERCEPT PHARMACEUTICALS 1 PFIZER 34 IONIS PHARMACEUTICALS 2 LEO 1 SANOFI 32 IPSEN 2 LFB 1 J&J - JANSSEN 29 MEDTRONIC 2 LIFEINA 1 BMS 22 PIERRE FABRE 2 MENARINI 1 AMGEN 20 PTC THERAPEUTICS 2 NEW YORK BLOOD CENTER BAYER 14 ROEHM-PHARMA 2 HOWARD MILSTEIN 1 BOEHRINGER INGELHEIM 12 SIEMENS 2 NORGINE GMBH 1 SERVIER 11 SYSMEX 2 NOVO NORDISK 1 BIOGEN 10 AFA CROHN RCH FRANCE 1 PEAR THERAPEUTICS 1 GILEAD SCIENCES 9 AKCEA THERAPEUTICS 1 PHARMAPHARM 1 ABBOTT 8 ALBANA PHARMA 1 PORTOLA 1 ASTRAZENECA 7 AMICUS 1 RECORDATI PHARMA 1 TAKEDA 7 ASTA PHARMA 1 SMITH & NETHEW 1 VERTEX PHARMACEUTICALS 7 BAXTER 1 SOFMEDICA 1 ELI LILLY 5 BD 1 SPARK THERAPEUTICS 1 MERCK KGAA 5 BIOCARTIS 1 STRYKER 1 CHIESI 4 BIOCHEM-PHARMA 1 SVR 1 LUNDBECK 4 BIOCODEX 1 SWEDISH ORPHAN AAZ-LMB 3 EDAP TMS 1 INTERNATIONAL 1 ABBVIE 3 EOS SAS 1 SYADEM - GROUPE D’ETUDES ACTELION 3 EXACT SCIENCES 1 EN PRÉVENTOLOGIE 1 ALEXION 3 FACULTY OF PHARMA ANGERS 1 T2 BIOSYSTEMS 1 ALNYLAM NETHERLANDS BV. 3 FERRER 1 TB ALLIANCE BOSTON SCIENTIFIC 3 FISONS 1 URGO MEDICAL 1 TEVA 3 FROSST 1 VIRON THERAPEUTICS 1 ALMIRALL 2 GENERIUM 1 Updated January 2021 ASTELLAS 2 GERMITECH 1

THE MEDAL BY ALBERT DE JAEGER

The Prix Galien medal was designed by Albert de Jaeger (1908 – 1992), laureate of the Premier Grand Prix de Rome architectural prize. De Jaeger designed medals for prominent figures such as Pope Pius XII (at the Villa Medicis, 1937) and Pope Jean-Paul I, Presidents Dwight D. Eisenhower and John F. Kennedy, distinguished military leaders including Marshals Leclerc, Koenig, Montgomery, Marshall and Joukov; the Weizmann Institute, as well as numerous artists, literary figures and prominent personalities such as Sacha Guitry, Marcel Proust, Henri de Montherlant, Paul Harris, a number of Nobel Prize laureates, the Empress of Iran SA Farah Diba, Princess Grace of Monaco, and others…

De Jaeger is also the architect of numerous outstanding monuments in France and throughout the world. 10 GALIEN AWARDS OCTOBER 28TH, 2O21 6:3O PM AMERICAN MUSEUM OF NATURAL HISTORY CEREMONY 2O21 NEW YORK CITY

The Galien Foundation continues to monitor recommendations from the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) and will abide by COVID-19 pandemic protocols.

Our annual gala awards dinner is a creative recognition of the productive and positive power of partnerships that drive progress in medical science. It is peer exchange with a public purpose - with a diverse range of opportunities for contact with a range of interests, from professional and scientific groups, academia and governments to patient associations, other non-profit organizations and the media.

WHAT PREVIOUS PRIX GALIEN WINNERS “Merck’s mission is to trans- “Our 2016 Prix Galien USA HAVE SAID UPON late science into medically awards [for Cosentyx and important products that positively impact Gleevec] … represent years of hard work RECEIVING humanity, so it is natural for us to support by our scientists. These wins underscore THE HONOUR the Prix Galien, since it supports exactly our commitment to addressing the unmet that.” medical needs of patients through sci- Kenneth C. Frazier ence-based innovation.” Chaiman, CEO and President, Merck Joseph Jimenez, CEO, Novartis

“The Galien Foundation “Our 2016 Prix Galien award “Our goal — to combine the brings together the top highlights not only the break- best science with the most scientists in the world. You have Nobel through science behind Cologuard, but efficient drug development plan and Laureates across the spectrum of scien- also the unrivaled team that worked to deliver transformational medicines to tific disciplines meeting and talking with develop and bring to market an innova- patients in need — is completely aligned members of the pharmaceutical indus- tion with the potential to make a signifi- with the Galien Foundation mission to try to see what’s going on at the cutting cant impact in eradicating colorectal can- promote innovations that improve the edge, because ultimately that’s going to cer. We are humbled and thankful to be human condition.” benefit patients.” counted among the companies honored Mace L. Rothenberg, MD William Hait, MD, PhD by the Galien Foundation.” Chief Development Officer, Oncology, Global Head, Research & Development, Graham Lidgard, PhD Pfizer Global Product Development Janssen, Pharmaceutical Companies of Chief Science Officer, Exact Sciences Johnson & Johnson 11 2O15 PR. MARY-CLAIRE KING PRO BONO Professor, Genome Sciences and Medical HUMANUM AWARD Genetics, University of Washington In recognition of her work in transforming The committee follows a century-old example set in Sweden. the application of human genetics to medicine through The Prix Galien rewards excellence and novelty, and awards special honors to identification of the first gene, BRCA1, responsible for those who have served humanity at large. Presented at the Ceremony, the Pro inherited susceptibility to breast cancer. And for pioneering Bono Humanum Award recognizes exemplary and innovative efforts in improving the application of genetic sequencing in forensics to identify the human condition. This special award was presented by the late and beloved victims of abuse. Elie Wiesel, in presence of the Prix Galien USA Committee. The Pro Bono Humanum Award was renamed theRoy Vagelos Pro Bono Humanum 2O14 Award in 2017 in recognition of his decades of leadership in improving the state of DR. BERNARD KOUCHNER human health through medicines innovation. Co-Founder, Doctors Without Border & Former French Minister of Foreign and European Affairs 2O20 In recognition of his role in the creation, from amongst French DR WILLIAM H. FOEGE doctors, this group of “Doctors Without Borders” who have lent In recognition of this role in building the global strategy the modern field of humanitarian medicine both legitimacy and that resulted in the eradication of this smallpox virus worldwide acclaim and for his fieldwork that has nurtured and in 1980, a success that helped foster higher rates of developed, not only among public opinion but also within various immunization against many other infectious and communicable governments, the notion of the universality of humanitarian diseases throughout the developing world. action and the concept of the Non-Governmental Organization. 2O19 2O13 JIM AND MARILYN SIMONS DR. ANTHONY FAUCI The Simons Foundation Director, U.S. National Institute of In recognition of their proactive support of basic Photo: Allergy and Infectious Diseases Tony Lopez scientific research undertaken in the pursuit of For his paramount contributions to basic and understanding the phenomena of our world, often including research by scientists clinical research on the pathogenesis and treatment of immune in the early stages of their careers, a new collaborative funding model to facilitate mediated and infectious diseases. cross-disciplinary breakthroughs, and efforts to inspire emerging and current philanthropists to dedicate a portion of their philanthropy to basic science. 2O12 2O18 DR. FRANCIS S. COLLINS BILL AND MELINDA GATES Director, U.S. National Institutes of Health Bill & Melinda Gates Foundation Dr. Collins, Director of the National Institutes In recognition of their extraordinary work of Health (N.I.H). In recognition of his contribution championing scientific and technological innovation to improve to the ethical implications of scientific research. life for the world’s poorest people. As co-chairs of the Bill & Melinda Gates Foundation, they have catalyzed unprecedented progress in global health, 2O11 poverty reduction, and public education in the U.S. PR. PAUL FARMER Chief Strategist and Co-Founder, 2O17 Partners In Health JIMMY CARTER For his humanitarian work in Haiti and Former U.S. President & Co-Founder, The Carter Center throughout the world, including advancing the fight against For playing a leadership role in the elimination of river blindness infectious diseases, including AIDS and tuberculosis. in four of the six Latin American countries where it was endemic and halting the disease’s transmission in several locations in Africa where more 2O1O than 99 percent of the global cases exist. BILL CLINTON AND PHILIPPE DOUSTE-BLAZY 2O16 Founder, Clinton Foundation and Former PAULA S. APSELL U.S. President; Chairman, UNITAID Executive Producer, PBS NOVA series & In recognition of their achievements in providing treatment and Director, Science Unit, WGBH increasing access to medicines for underserved populations through the UNITAID and Clinton Foundation HIV/AIDS Initiative For turning great science into a human story, showing that (CHAI) partnership. scientific literacy is society’s first line of defense against the destructive forces of fear and ignorance that challenge further progress in human health.

12 2OO9 BARRY BLOOM AND JEFFREY SACHS Professor of Public Health, Harvard University; Director, Earth Institute, Columbia University Harvard Professor Barry Bloom for bringing the fruits of basic biological science to those who are most needy. Columbia University Earth Institute Director Jeffrey Sachs for bringing the fruits of scholarly economics to bear our problems that have plagued the world for millennia. 2OO8 PRIX GALIEN USA SHELDON SEGAL AND THE GALIEN FOUNDATION POPULATION COUNCIL Former Chairman, Population Council For their global efforts in support of reproductive health and AN UNRIVALED REPUTATION family planning. FOR INTELLECTUAL RIGOR 2OO7 AND INTEGRITY… P. ROY VAGELOS Retired Chairman and CEO Merck & Co., Inc.; Chairman of the Board Regeneron Pharmaceuticals, Inc. For the River Blindness Program and his historic decision to donate the drug Mectizan to more than 530 million people in 34 countries to treat and prevent river blindness “as much as necessary for as long as necessary.”

WHO WAS GALIEN?

Born in 131AD, Galien is considered the father of modern medicine and pharmacology. As an anatomist, physiologist, clinician and researcher, his work formed the basis of a school of thought known as “Galenism”, which dominated medicine until the Renaissance. In fact, Galien’s works were used as primary medical reference for nearly two centuries. Raised in Pergamos, he studied in Smyrna, Corinth, and Alexandria, the three centers of medical excellence in the ancient world. Legend Elie Wiesel, Peace Nobel Laureate; has it that Galien was visited by Aesclapius in a dream and that this BAN Ki-moon, General Secretary, United Nations; inspired the direction of his life.A greek physician in Roma: when he Bill Clinton & Philippe Douste-Blazy, was 17, Galien worked as a physician to the gladiatorial school. At the 2010 Prix Galien Pro Bono Humanum Award Laureate age of 37, Marcus Aurelius summoned him to Rome, where he grew in reputation and stature as a healer, teacher, researcher and writer. His ideas on the functioning of the human body were so well received The Prix Galien USA Committee, a group of highly that he became the personal doctor of young Commodus, the heir to accomplished individuals from the scientific and the Emperor. He died in 201AD. During his long and eminent career, research communities, will judge which among Galien completed over 500 learned works addressing anatomy, the candidates, independent of any category, physiology, pathology, medical theory and practice, and many forms is the Best Pharmaceutical Agent (i.e. small of therapy. He traveled throughout the world, studying local plants molecule), the Best Biotechnology Product and and remedies, eventually describing 473 original drugs and many the Best Medical Technology approved by the substances of mineral and vegetable origin. Importantly,Galien was FDA in the past five years. As few as one or as the first to codify the art of preparing active drugs using multiple ingredients. Galien’s faculties of observation, logic and deduction many as three prizes may be awarded in each of made him the true successor of Hippocrates, and his declaration these categories, and the committee may decide that the primary aim of medicine was patient care formed the very on awards hors prix. The prizes are awarded for cornerstone of modern pharmacy.To quote Jean-Pierre Changeux, products and agents that significantly improve “Galen first showed that our mind was in the brain, not in our hearts.” the human condition. It can be said that this was the beginning of experimental medicine. 13 GALIEN FORUM OCTOBER 28, 2O21 - 7:3O AM ALEXANDRIA CENTER FOR LIFE SCIENCE NEW YORK CITY

The Galien Foundation continues to monitor recommendations from the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) and will abide by COVID-19 pandemic protocols.

The Galien Forum, held every autumn at New York’s Alexandria Center for Life Sciences since 2010, offers TOPICS DEBATED AT PREVIOUS a full day of dynamic presentations and spirited FORUMS INCLUDE: discussions with top scientists and industry researchers • Cancer Immunotherapeutics who offer perspectives on the most significant • The Brain Initiative challenges in the global burden of disease and • Personalized Medicine’s Impact on Drug R&D highlights the latest research and clinical pathways and Patient Care toward diagnosis, treatment, and cure. • Improving Efficiency in Drug Development • What is “Value” and How Can it be Measured Our 700 attendees represent the top executive and thought and Demonstrated in Therapeutic Innovations? leadership from academic research, industry, government, • U.S. Health Reform the regulatory community, patient organizations, international organizations, and the media. Time and again, • A New Agenda for Global Health Forum participants praise the caliber of the speakers and • The Future of Digital Health and its Impact their fellow attendees, the quality of the panel discussions on Healthcare and presentations, and the recognition of industry’s critical • New Mechanisms for Industry-Academia role in creating life-saving innovations. Collaboration • The Future of Targeted Drug Delivery These events represent peer-to-peer exchange with a public purpose, featuring unique opportunities to connect with a • Microbiota in Human Disease diverse range of people, organizations and interests from • Autism - The Next Decade professional and scientific groups, academia, governmental • Untangling the Web of Neurodegeneration organizations and patient associations, non-profit • Precision Medicine: Delivering on the Promise organizations and the media. Molecular Scissors: What Can We Expect from Gene Editing?

14 AMONG THE PREVIOUS GALIEN FORUM SPEAKERS

Richard AXEL, MD Nobel Laureate Joseph GOLDSTEIN Nobel Laureate Guido RASI Co-director, Kavli Institute for Brain Science, Professor of Molecular Genetics and Internal Executive Director, European Medicines Columbia University Medical Centre Medicine, UT, Southwestern Medical Center at Agency Dallas Stephane BANCEL Michael ROSENBLATT, MD Chief Executive Officer, Moderna, Inc. Dr Alex GORSKY Chief Medical Officer, Flagship Ventures Chaiman and CEO, Johnson & Johnson Cori BARGMANN, PhD Bengt SAMUELSSON, MD, PhD Nobel Rockefeller University Dr. Scott GOTTLIEB, MD Laureate Former Commissioner, U.S. FDA Michael BLOOMBERG Former President, Karolinska Institute Former Mayor, City of New York Paul GREENGARD, PhD Nobel Laureate Former Chairman, Nobel Foundation Professor of Molecular and Cellular Albert BOURLA, DVM, PHD, George A. SCANGOS, PhD Neuroscience, Rockefeller University Chief Executive Officer, Pfizer Inc. Chief Executive Officer, Vir Biotechnology, Inc. William N. HAIT, MD, PhD Michael S. BROWN Nobel Laureate Steven H. STEIN, MD Global Head, Research and Development, Professor of Molecular Genetics and Internal Senior Vice President US Clinical Janssen Research & Development Medicine, UT Southwestern Medical Center at Development & Medical Affairs, Novartis Dallas Margaret A. HAMBURG, MD Oncology US Former Commissioner, U.S. Food and Drug Rory COLLINS Marc TESSIER-LAVIGNE, PhD Administration Co-director, University of Oxford Clinical Trials President, Stanford University Unit Penny M. HEATON Eric TOPOL, MD MD, Chief Executive Officer, The Bill & Melinda Sue DESMOND-HELLMANN, MD, MPh, Director & Founder, Scripps Research GatesMedical Research Institute Prix Galien USA Committee Translational Institute; Author, Deep Learning Former Chief Executive Officer, Eric R. KANDEL, MD Nobel Laureate P. Roy VAGELOS, MD Bill & Melinda Gates Foundation Professor of Physiology and Cellular Biophysics, Retired Chairman and CEO, Merck & Co., Inc.; Columbia University; Director Bio-technology Mikael DOLSTEN, MD, PhD Chairman of the Board, Regeneron Study Center, NYU School of Medicine President, Worldwide Research and Pharmaceuticals Development, Pfizer John LECHLEITER Bert VOGELSTEIN Chairman and CEO, Eli Lilly & Company Ezekiel EMANUEL, MD, PhD Professor, Johns Hopkins Medical School Vice Provost for Global Initiatives; Chair, Dr Jeffrey LEIDEN Dept. of Medical Ethics and Health Policy Levy; Chairman, President and CEO, Vertex Michel VOUNATSOS University Professor Perelman School of Chief Executive Officer, Biogen Donald LLOYD-JONES Medicine and The Wharton School, University of Chairman, Department of Preventive Medicine, Christophe WEBER, PharmD Pennsylvania Northwestern University Representative Director, President & Chief Jacqualyn FOUSE, PhD Executive Officer, Takeda Pharmaceutical Joel S. MARCUS Chief Executive Officer, Agios Company Limited Chairman, CEO & Founder, Alexandria Kenneth C. FRAZIER Real Estate Equities / Alexandria Venture George YANCOPOULOS, MD, PhD Chaiman, CEO and President, Merck Investments; Co-Founder Alexandria Summit Chief Scientific Officer, Regeneron Pharmaceuticals; President, Regeneron Maria C. FREIRE, PhD Mark McCLELLAN, MD, PhD Laboratories President & Executive Director, Foundation for Director, Duke-Robert J. Margolis Center for the National Institutes of Health Health Policy; Professor of Business, Medicine, Krishna YESHWANT, MD and Health Policy, Duke University General Partner, Google Ventures Laurie GLIMCHER, MD CEO and President Dana Farber Cancer Institute; Elizabeth NABEL Elias ZERHOUNI Professor of Medicine, Harvard Medical School MD, President, Brigham and Women’s Hospital Former President, Global R&D, Sanofi

15 OCTOBER 28, 2O21 / AMERICAN MUSEUM OF NATURAL HISTORY

AND THE 2O21 WINNER IS?

The Prix Galien Award recognizes ACTORS WIN outstanding achievements in improving OSCARS the global human condition through ... the development of innovative drugs and other treatments. INNOVATORS WIN PRIX GALIEN USA The Prix Galien was created in 1970 in honor of Galien, the father of medical science and modern pharmacology.

Worldwide, the Prix Galien is regarded as the equivalent of the Nobel Prize Tegsedi® / ONPATTRO® / VYNDAQEL® / in biopharmaceutical research. HALL OF Pretomanid 2020 Abbott’S Mitraclip™ Transcatheter 2020 FAME Mitral Valve Repair System 2019 SHINGRIX / LUXTURNA™ 2019 FreeStyle® Libre

® ® ® 2018 IDHIFA / Yescarta / Kymriah 2018 Watchman™ Left Atrial Appendage Closure Device

Exablate Neuro® 2017 TM 2017 Spinraza® / Venclexta

2016 Cologuard® / Cosentyx® / Ibrance® 2016

2015 Imbruvica®/ Keytruda®/ Opdivo® 2015 T2Candida Panel

2014 HemacordTM / Trevo®ProVueTM / Sovaldi® 2014 2013 S-ICD® System / Zelboraf® / Zostavax® 2013

2012 Prevnar13® / Prolia and XGEVA® / Stelara® 2012 2011 Incivek® / Melody® / Sapien® / Victrelis® Yervoy® 2011 2010 Coartem® / Rotateq® / xTAG® 2010 2009 Cellsearch® / Gleevec® / Nplate® / Promacta® 2009 2008 Infuse® / Isentress® / Revlimid®/ Selzentry® / Soliris® 2008 2007 Chantix® / Gardasil® / Humira® / Januvia® 2007

The Galien Foundation 99 John Street, Suite 2502 / New York, NY 10038 Tel: 212-685-1592 www.galienfoundation.org