VOLUME 216 JANUARY-MARCH 1981 THE JOURNAL OF Pharmacology AND EXPERIMENTAL THERAPEUTICS

FOUNDED BY JOHN J. ABEL 1909

Official Publication of The American Society for Pharmacology and Experimental Therapeutics, Inc.

EDITOR

Eva King Killam

ASSISTANT EDITOR

Mannfred A. Hollinger

EDITORS FOR SPECIFIC FIELDS

Analgesia and Drug Abuse Drug Metabolism and Disposition Joseph Cochin Edward Bresnlck Vincent G. Zannoni Autonomic Pharmacology Robert E. Stltzel Gastrointestinal Pharmacology Behavioral Pharmacology Thomas F. Burks Roger T. Kelleher Immunopharmacology Cardiovascular Pharmacology Sydney Spector Henry R. Besch, Jr. Neuropharmacology Michael J. Brody Charles 0. Rutledge Benedict R. Lucchesi Wallace D. Winters Cell Pharmacology Toshio Narahashi Pulmonary Pharmacology Mannfred A. Hollinger George B. Weiss

Chemotherapy Renal !fharmacology H. George Mandel William 0. Berndt

Developmental Pharmacology Toxicology Bernard L. Mirkin Curtis D. Klaassen

EDITORIAL ADVISORY BOARD

Martin W. Adler Robert Z. Gussin Lanissa A. Pohorecky Edson X. Albuquerque Anthony J. Hance James W. Putney, Jr. Edmund G. Anderson Harold F. Hardman Arthur Raines Leslie E. Bailey Louis S. Harris G. Alan Robison John A. Bevan John A. Harvey C. R. Ross C. Paul Bianchi Philip C. Hoffmann Betty I. Sasyniuk Leslie C. Blaber Jordan L. Holtzman Arnold Schwartz David A. Blake Stephen G. Holtzman Lewis S. Seiden John R. Blinks Jerry B. Hook Eric J. Simon Floyd E. Bloom David M. Jacobowitz Roger P. Smith Theodore M. Brody Donald R. Jasinski Robert I. Taber Theodore J. Cicero Alain F. Junod A. E. Takemori E. E. Daniel Conan Kornetsky Robert TenEick William C. de Groat Edwin A. Kroeger Thomas R. Tephly Linda Dykstra Wayne Levin C. D. Thron Hugh L. Evans John C. McGiff U. Trendelenburg James A. Ferrendelli Donald E. McMillan Betty M. Twarog Lawrence J. Fischer Jerry Mitchell Norman J. Uretsky William W. Fleming Perry B. Molinoff Martin A. Wasserman Shn N. Gin W. H. Morse Richard M. Welch Dora B. Goldstein Mary J. Mycek David P. Westfall Frank R. Goodman Robert A. Neal Martin M. Winbury Charles W. Gorodetzky Achillos J. Pappano Ben G. Zimmerman William A. Pettinger BOARD OF PUBLICATIONS TRUSTEES

NORMAN WEINER, Chairman; GEORGE I. DRUMMOND, LEON I. GOLDBERG, EVA KING KILLAM, NORMAN KIRSHNER, KENNETH C. LEIBMAN, GILBERT J. MANNERING, WALTER MODELL, PAUL L MUNSON, SIDNEY UDENFRIEND EXECUTIVE OFFICER OF THE SOCIETY

HOUSTON BAKER COPYRIGHT © 1981 BY THE WILLIAMS & WILKINS COMPANY Announcing publication of The American Physiological Society’s Handbook of Physiology Section 2: The Cardiovascular System

Volume Editors: FIG. 29. Diagram illustrating behavior David F. Bohr, M.D. of series-coupled myogenic effectors. Andrew P. Somlyo, M.D. Upper panel shows consecutive vascular senents. Lower panel illustrates pres- Harvey V. Sparks, Jr., M.D. sure gradient in control state and at Publisher: reduced pressure. 1, control; 2, after 20% arterial pressure reduction; 3, after 40% The American arterial pressure reduction. For purposes Physiological Society of illustration, the pressure gradient is Distributor: taken to be more nearly linear than is the case in the arteriolar network. [From The Williams & Wilkins Company laLone and Johnson, unpublished data.) Baltimore and London

Vascular Smooth Muscle provides the physiolo- 0 Biochemistry gist, pharmacologist, biochemist and biophysicist Pioneering new work on the contractile and with a comprehensive review of the structure, regulatory protein, the chemical functions of the chemistry and function of that contractile system subcellular particles, and the energy metabolism of the blood vessel wall. of the cell It is an essential sourcebook for research 0 Electrolytes and Electrophysiology workers, graduate students, teachers, and clini- Electrolyte content and fluxes in vascular cians who need basic information regarding: smooth muscle, and how these influence the 0 the mechanism for contraction and relaxation membrane and action potentials of the cell. of vascular smooth muscle The all-important role of calcium in excitation- o the physiological regulation systems for con- contraction coupling is presented. traction and relaxation of vascular smooth 0 Muscle Mechanics muscle Contractile mechanics of the individual cell and o the architecture, ultrastructure and morpho- of the vessel wall as a whole, and the circula- genesis of the blood vessel wall tory correlations of compliance, resistance and 0 current understanding of abnormalities that capacitance of the vascular tree develop in vascular smooth muscle function. o Phylogenetic Variations The 21 chapters are organized into six sections that The epilogue relates smooth muscles to other deal with vascular smooth muscle from the following contractile systems. perspectives: 0 Structure The relationship of the smooth muscle wall to the Ordering Information architecture of the blood vessel wall, the ultra- VASCULAR SMOOTH MUSCLE (ISBN: 0-683- structure of the individual cell, and the morpho- 00606-1), 1980, 694 pages, 331 figures, $95.00 genesis of vascular smooth muscle Send all orders and inquiries to the distributor: Williams & Wilkins, 428 East Preston Street, Baltimore, MD 21202, or call toll-free (9:00 a.m. to 4:00 p.m.), 1-800-638-0672. In Maryland, call 528-4221.