Anti-PDLIM3 (Full Length) Polyclonal Antibody (CABT-BL5370) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PDLIM3 (full length) polyclonal antibody (CABT-BL5370) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse polyclonal antibody to Human PDLIM3.

Antigen Description The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene.

Specificity Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.

Immunogen Full length human protein (AAH27870, 1 aa ~ 317 aa).

Isotype IgG

Source/Host Mouse

Species Reactivity Human

Purification Protein A purified

Conjugate Unconjugated

Sequence Similarities Contains 1 LIM zinc-binding domain.Contains 1 PDZ (DHR) domain.

Cellular Localization Cytoplasm; myofibril; sarcomere; Z-disk. Localizes to myofiber Z-lines.

Format Liquid

Size 50 μg

Buffer 1×PBS, pH 7.2

Preservative None

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]

GENE INFORMATION

Entrez Gene ID 27295

Protein Refseq NP_001107579

UniProt ID Q53GG5

Chromosome Location 4q35

Function actinin binding; metal ion binding; structural constituent of muscle; zinc ion binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]