Anti-PDLIM3 (full length) polyclonal antibody (CABT-BL5370) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse polyclonal antibody to Human PDLIM3. Antigen Description The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. This gene is found near a region of chromosome 4 that has been implicated in facioscapulohumeral muscular dystrophy, but this gene does not appear to be involved in the disease. Two transcript variants encoding different isoforms have been found for this gene. Specificity Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific. Immunogen Full length human protein (AAH27870, 1 aa ~ 317 aa). Isotype IgG Source/Host Mouse Species Reactivity Human Purification Protein A purified Conjugate Unconjugated Sequence Similarities Contains 1 LIM zinc-binding domain.Contains 1 PDZ (DHR) domain. Cellular Localization Cytoplasm; myofibril; sarcomere; Z-disk. Localizes to myofiber Z-lines. Format Liquid Size 50 μg Buffer 1×PBS, pH 7.2 Preservative None Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved BACKGROUND Introduction The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012] GENE INFORMATION Entrez Gene ID 27295 Protein Refseq NP_001107579 UniProt ID Q53GG5 Chromosome Location 4q35 Function actinin binding; metal ion binding; structural constituent of muscle; zinc ion binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.