Food Crime Strategic Assessment 2020
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Prions and Neuro Degenerative Diseases
African Journal of Biotechnology Vol. 10(13), pp. 2366-2374, 28 March, 2011 Available online at http://www.academicjournals.org/AJB DOI: 10.5897/AJB09.582 ISSN 1684–5315 © 2011 Academic Journals Review Prions and neuro degenerative diseases Rahul R. Nair* and Jerin K. Johnson II MTech Biotechnology, School of Biotechnology, Karunya University, Karunya Nagar, Coimbatore, Tamil NADU- 641114, India. Accepted 2 June, 2009 Prion is a disease-causing agent that is neither bacterial nor fungal nor viral and contains no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. Prions have been held responsible for a number of degenerative brain diseases, including scrapie (a fatal disease of sheep and goats), mad cow disease, Creutzfeldt-Jacob disease, fatal familial insomnia, kuru, an unusual form of hereditary dementia known as Gertsmann-Straeussler-Scheinker disease, chronic wasting disease in deer and elk, bovine spongiform encephalopathy (BSE, commonly known as “mad-cow” disease), exotic ungulate spongiform encephalopathy, Transmissible Mink Encephalopathy (TME), and feline spongiform encephalopathy, albino tigers, pumas, and cheetahs. Currently, definite diagnosis of prion diseases is still considered to be possible only after histopathological examination of biopsied or autopsied brain material. Prion diseases do not stimulate immunity. Therefore, a vaccine that prevents them is unlikely. No treatment is available either, although research in this area is progressing. Key words: Prion, transmissible spongiform encephalopathies, diagnosis, treatment. INTRODUCTION A prion has been defined as "small proteinaceous in- holes in the brain. -
Prion Diseases: a Challenge to Animal Health Received On: 16-12-2011 Revised On: 26:12:2011 Accepted On: 29-12-2011
Journal of Applied Pharmaceutical Science 01 (10); 2011: 215-221 ISSN: 2231-3354 Prion diseases: A challenge to animal health Received on: 16-12-2011 Revised on: 26:12:2011 Accepted on: 29-12-2011 Dudhatra G.B, Mody S.K, Patel H.B, Modi C.M, Avinash Kumar and Awale M.M ABSTRACT Prion diseases are known as transmissible spongiform encephalopathies (TSE), a group of rare, rapidly progressive, and fatal neurologic diseases. The agents responsible for human and animal prion diseases are abnormal proteins (prion or proteinaceous infectious particle) that can Dudhatra G.B, Mody S.K, trigger chain reactions causing normal proteins in the brain to change to the abnormal protein. Patel H.B, Modi C.M, These abnormal proteins are resistant to enzymatic breakdown, and they accumulate in the brain, Avinash Kumar and Awale M.M leading to damage. All have long incubation periods followed by chronic neurological disease and Department of Pharmacology and fatal outcomes, have similar pathology limited to the CNS include convulsions, dementia, ataxia Toxicology, College of Veterinary (balance and coordination dysfunction), and behavioral changes, and are experimentally Science and Animal Husbandry, Sardarkrushinagar Dantiwada transmissible to some other species . Agricultural University, Sardarkrushinagar, Gujarat, India-385506. Keywords: Bovine spongiform encephalopathy, Chronic wasting disease, Exotic ungulate encephalopathy, Feline spongiform encephalopathy, Mad cow disease, Prion, Scrapie and Transmissible mink encephalopathy. INTRODUCTION The word prion, coined in 1982 by Dr. Stanley B. Prusiner, is a portmanteau derived from the words protein and infection, and prion was proposed to “denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids” (Prusiner, 1982). -
Perceptions of the Authenticity of Food: a Study of Residents in Dorset (UK)
Perceptions of the authenticity of food: a study of residents in Dorset (UK) Sean Christopher Beer A thesis submitted in partial fulfilment of the requirements of Bournemouth University for the Degree of Doctor of Philosophy October 2015 Bournemouth University Abstract In this thesis I critically explore the relationship between authenticity, the individual, society and the food consumed within that society for a group of residents in Dorset in the United Kingdom. The authenticity of food impacts on our understandings of the economic, social, political and environmental contexts of food and is worthy of research. As such I focused on my participants’ perceptions of the authenticity of food as something a priori; as it was perceived before other considerations, in ordered to get a primary understanding of the subject. I have positioned myself as a reflexive explorer / researcher who views the world from the position of interpretive constructionism derived from the ideas of postmodernism. I have utilized a qualitative research strategy; phenomenology and more specifically Interpretative Phenomenological Analysis (IPA). My explanation of the methodology is accompanied by a description of the philosophical underpinning to the work with specific reference to Husserl, Heidegger, Gadamer, Levinas and Derrida. Data were collected using focus groups based around a meal. When I asked my focus group participants about their perspectives on the nature of the authenticity of food, they described understandings that were vested in four key areas: Family and friends; Saucing: cooking and flavour; Sourcing: where does it come from? and; Interaction with the distinctly other (people that were not friends and family). In terms of the discussion of family and friends, much of this was to do with their experiences of growing up and their relationships with their parents and grandparents. -
Benders' Dictionary of Nutrition and Food Technology
BDOPR 10/7/99 4:25 PM Page iii Benders’ Dictionary of Nutrition and Food Technology Seventh Edition David A Bender BSc, PhD, RNutr Senior Lecturer Department of Biochemistry and Molecular Biology University College London and Arnold E Bender DSc (hc), PhD, HonMAPHA, HonFRSH, FIFST Emeritus Professor of Nutrition University of London Cambridge England ©1999 Woodhead Publishing Ltd. BDOPR 10/7/99 4:25 PM Page iv Published by Woodhead Publishing Limited, Abington Hall, Abington Cambridge CB1 6AH, England Published in North and South America by CRC Press LLC, 2000 Corporate Blvd, NW Boca Raton FL 33431, USA First published 1960 Second edition 1965 Third edition 1968 Fourth edition Newnes-Butterworth 1975 Fifth edition Butterworth Scientific 1982 Reprinted 1984 Sixth edition 1990 Reprinted 1998 Woodhead Publishing Ltd Seventh edition 1999, Woodhead Publishing Ltd and CRC Press LLC © 1999, Woodhead Publishing Ltd The authors have asserted their moral rights. This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. Reasonable efforts have been made to publish reliable data and information, but the authors and the publishers cannot assume responsibility for the validity of all materials. Neither the authors nor the publishers, nor anyone else associated with this publication, shall be liable for any loss, damage or liability directly or indirectly caused or alleged to be caused by this book. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming and recording, or by any information storage or retrieval system, without permission in writing from the publishers. -
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