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Collaborative Drug Discovery's 10 Anniversary Community Meeting

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Collaborative Drug Discovery's 10 Anniversary Community Meeting Collaborative Drug Discovery’s 10th Anniversary Community Meeting April 4th, 2014 8am-6pm UCSF Mission Bay Conference Center 1675 Owens St. San Francisco, CA 94158 Please use this Twitter hashtag for the event: #CDDx14 Agenda 7:45 Registration - refreshments in Foyer and Exhibition room 8:15 Opening Remarks - with UCSF Host, Stephanie Robertson and CDD CEO, Barry Bunin Collaborative Workflow: Basic and Advanced Use Cases of CDD Vault 8:20 Charlie Weatherall (CDD) & Anna Spektor (CDD) 9:10 Morning Sessions - moderated by Sylvia Ernst (CDD) The Rockefeller University Compound Screening Library 9:15 J. Fraser Glickman (Rockefeller University) Recent Progress in De-Orphanization of Nuclear Receptors 9:40 Ruo Steensma (Orphagen Pharmaceuticals) 10:05 Morning Break - located in the Foyer and Exhibition room Large small molecules in a Small large molecule world 10:35 Leanna Staben (Genentech) Linking the Molecular Structure of Medicines to their Biological Effects 11:00 Bob Volkmann (Systamedic & Mnemosyne Pharmaceuticals) Panel: Externalized Research - What Makes a Good Partnership? Wisdom from Experts 11:25 Who've "Been There - Done That," moderated by Sylvia Ernst (CDD) 11:50 Lunch - boxed lunches in the Foyer and Exhibition room Optional: “What if CDD had...” provide feedback to our product team (12:35) Kellan Gregory (CDD) 10 Years Evolving Our Collaborative Drug Discovery Vaults 1:05 Barry Bunin (CDD) CDD Vault: Noteworthy recent enhancements and a preview of things to come 1:30 David Blondeau (CDD) & Kellan Gregory (CDD) 2:20 Afternoon sessions - moderated Christopher Lipinski The Tuberculosis Drug Accelerator: A New Paradigm For Drug Discovery 2:25 Jerry Shipps (Tuberculosis Drug Accelerator) The role of NIAID in the development of therapeutics for Infectious Diseases 2:50 Martin John Rogers (NIAID) 3:15 Afternoon Break - located in the Foyer and Exhibition Room Targeting the Immunoproteasome 3:40 Dustin L. McMinn (Onyx Pharmaceuticals) Hit Generation for the Treatment of Prion Diseases Using Phenotypic Screens 4:10 Joel Gever (UCSF) Exploiting Bigger Data and Collaborative Tools for Predictive Drug Discovery 4:35 Sean Ekins (CDD) Lipinski CDD 10th Anniversary Thoughts on Drug Discovery 5:00 Christopher Lipinski Panel: Perspectives on Drug Discovery Collaborations 5:30 moderated by Christopher Lipinski 5:55 Wine and Cheese Reception - located in the Foyer Program Opening Remarks and Introductions Stephanie Robertson, PhD. Senior Director, Strategic Alliances, Office of Innovation, Technologies & Alliances, UCSF Stephanie Robertson, PhD, is the Senior Director of Strategic Alliances in the Office of Innovation, Technologies & Alliances (ITA) at the University of California, San Francisco. ITA was established in 2011 under the Office of Research with the goal of providing a single interface for external partners of UCSF. Dr. Robertson developed one of the first formal alliance management teams found in an academic setting, allowing her group to provides a constant interface throughout the lifecycle of large partnership relationships, beginning at the start of alliance development, throughout the collaboration and back to the partner for strategic evaluation of expansion, extension and additional alliances. Dr. Robertson joined UCSF in 2009 as Program Director for the Sandler Center for Drug Discovery and also helped in the establishment and oversight of the UCSF Grand Multiple Myeloma Translational Initiative (GMMTI). Prior to joining UCSF, Dr. Robertson worked for ten years at Exelixis, Inc. During her tenure at Exelixis the company grew from start-up to over 700 employees. Her most recent position of Associate Director of R&D held responsibilities that included serving as a scientific project leader for drug discovery programs in cancer, cardiovascular disease and metabolism, as well as providing alliance management for several programmatic collaborations with large pharma. She also provided project management as discovery programs progressed into early phase clinical programs. She earned an undergraduate degree in chemistry (Honors) at the University of Michigan, Ann Arbor, and a Ph.D. in chemistry at the University of California, Berkeley. Collaborative Workflow: Basic and Advanced Use Cases of CDD Vault Abstract CDD Vault™ is a hosted biological and chemical database that securely manages your private and external data. This session is aimed at introducing the CDD Vault as a data management platform for real-time collaborative research, be it within the confines of your own lab, or with partners across the globe. If you are an advanced CDD Vault user already, you are probably one of the collaborators on such a project. This session will present a 360 degree view of the work-flows that involve all members of the collaboration: synthetic and medicinal chemistry, SAR, biological assay data management and the communications that surround the data. We will also give a sneak-peak at the newest capabilities of the CDD Vault. Charlie Weatherall Strategic Technical Account Manager, Collaborative Drug Discovery Charlie attributes his extreme customer dedication to two things. First, he is a true Southern gentleman who cares greatly about other people. Second, he started his career as an R&D end-user of multiple scientific applications and has never forgotten what it’s like to “be the customer.” Charlie has over two decades of experience working with industry leading scientific software companies such as MDL (dating back to ISIS version 0.9 in ’91), SciTegic, Accelrys, CambridgeSoft, and IDBS. He has traveled extensively installing software, providing training, and leading workshops at customer sites and conferences. Customers throughout the world (including Japan, Australia, Great Britain, France, New Jersey and Illinois) have been known to alter their schedules to match Charlie’s availability for visiting their sites. Charlie is looking forward to being the best customer advocate and trusted advisor for the CDD community. Anna Spektor Customer Success Manager, Collaborative Drug Discovery Anna has extensive experience managing client relationships for top 10 pharma companies, helping to organize and analyze their data efficiently and effectively. Anna also coordinates CDD training, and creates customized data strategies and solutions. Anna began her career as a chem- and bio-informatics consultant and has experience of other software such as IDBS’ ActivityBase. Not only is she proficient in database software and solutions in the pharma sector, she understands the world of academia, having obtained a Master of Science in Biomedical Engineering, and a degree in Molecular Biology from the University of Chicago, and having spent 10 years as an academic researcher. Morning Session Sylvia Ernst, Ph.D. (moderator) Head of Sales and Sales Operations, Collaborative Drug Discovery Dr. Sylvia Ernst received her Ph.D. in Chemistry in Frankfurt, Germany working in the group of Prof. Dr. Wolfgang Kaim. At that time her research focused on using computational chemistry to find new catalysts for exploiting energy from sunlight. She has over 20 scientific publications. Interested in Chemical information and technology, she joined the Beilstein Institute and was a member of the core team which launched “CrossFire Beilstein”, a database which today is known and used by almost every chemist in the world. From there Sylvia worked in customer related functions with Beilstein Information Systems, MDL Information Systems, Elsevier MDL, and SciTegic/Accelrys. She joined CDD in 2007. Sylvia’s extensive work with many pharmaceutical and biotech companies as well as academic and government institutions spans the globe, giving her a unique perspective on how the drug discovery and development process is evolving, and how new approaches may impact world health. She joined CDD because she believes that the best response to emerging global health crises is to foster collaborations that join the world’s enormous research capabilities into unified efforts. The Rockefeller University Compound Screening Library Abstract The Rockefeller University High Throughput and Spectroscopy Resource Center (HTSRC) was established in 2003 with a 4000 compound library. Since that time the center has grown to have a collection of 215,000 compounds, a sophisticated LIMS, automated storage and retrieval systems, a broad array of modern assay technologies staffed by 5 technology experts. The Center is used by over 60 laboratories, with 160 visiting scientists, from Rockefeller, Weill-Cornell Medical College and around the globe. In this presentation we will share our experience on the challenges of building-up an academic screening library, the strategies and pitfalls for compound purchase, and the way we have used databases and informatics systems to understand and annotate the library, sharing information across multiple sites. J. Fraser Glickman, Ph.D. Director of the High Throughput and Spectroscopy Resource Center and Research Assistant Professor, Rockefeller University J. Fraser Glickman received his BS in Zoology from Duke University in 1984, his MS in Public Health Parasitology from the University of North Carolina in 1987, and his Ph.D. in biochemistry from University of California, Santa Barbara in 1997. He is currently the director of The High Throughput and Spectroscopy Resource Center at the Rockefeller University and a Research Assistant Professor and member of the faculty of the Center for Clinical and Translational Sciences. He has formerly been a research scientist
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