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(12) United States Patent (10) Patent No.: US 8,129,142 B2 Mulley Et Al USOO81291 42B2 (12) United States Patent (10) Patent No.: US 8,129,142 B2 Mulley et al. (45) Date of Patent: Mar. 6, 2012 (54) MUTATIONS IN ION CHANNELS 2004/0214195 A1 10/2004 Rouleau et al. 2004/0229257 A1 11/2004 Petrou et al. 2005/OO74764 A1 4/2005 Mulley et al. (75) Inventors: John Charles Mulley, Firle (AU): 2006.0089306 A1 4/2006 Wallace et al. Louise Anne Harkin, Northgate (AU); 2006/0252121 A1 11/2006 Wallace et al. Leanne Michelle Dibbens, College Park 2010.0088778 A1 4/2010 Mulley et al. (AU); Hilary Anne Phillips, Port Noarlunga (AU); Sarah Elizabeth FOREIGN PATENT DOCUMENTS Heron, Highbury (AU); Samuel Frank AU 65.6247 6, 1996 WO WO84,03564 9, 1984 Berkovic, Caulfield North (AU); Ingrid WO WO97/02048 1, 1997 Eileen Scheffer, Hawthorn East (AU): WO WOO1/38564 5, 2001 Anne Davy, North Adelaide (AU) WO WOO1/88125 11, 2001 WO WOO1/98486 12/2001 (73) Assignee: Bionomics Limited. Thebarton, SA WO WOO2,06521 1, 2002 WO WOO2,06521 A1 1, 2002 (AU) WO WOO2,50096 6, 2002 WO WOO2,50096 A1 6, 2002 (*) Notice: Subject to any disclaimer, the term of this WO WOO3,OO8574 1, 2003 patent is extended or adjusted under 35 WO WOO3,OO8574 A1 1, 2003 U.S.C. 154(b) by 1031 days. WO WO 2004/085674 10, 2004 WO WO 2004/085674. A 10, 2004 (21) Appl. No.: 10/567,424 WO WO 2005/O 14863 2, 2005 (22) PCT Filed: Aug. 6, 2004 OTHER PUBLICATIONS Nabbout et al. Jun. 2003 (Neurology 60: 1961-1967).* (86). PCT No.: PCT/AU2OO4/OO1051 Breaker et al., “A DNA enzyme with MG^2+-dependent RNA S371 (c)(1), phosphoesterase activity”, Chemistry & Biology, 2: 655-660, Oct. (2), (4) Date: Dec. 9, 2008 1995. Cole et al., “Human monoclonal antibodies'. Molecular and Cellular (87) PCT Pub. No.: WO2005/014863 Biochemistry, 62: 109-120, 1984. Cote et al., “Generation of human monoclonal antibodies reactive PCT Pub. Date: Feb. 17, 2005 with cellular antigens'. 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