Genetic Characterization of Iranian Subpopulations Using 15 Forensic Autosomal STR Loci
Eurasian Journal of Anthropology Euras J Anthropol 6(2):39−52, 2015 Genetic characterization of Iranian subpopulations using 15 forensic autosomal STR loci Mostafa Ghaderi-Zefrehei1∗, Amin Mortazavi2, Zohreh Baratieh3, Alireza Sabouri4, Reza Alaeddini5, Somayeh Heidari6, Elahe Foroughimanesh1 1Systems Biology, University of Yasuj, Yasuj, Iran 2Breeding Genetics, University of Kurdistan, Kurdistan, Iran 3Molecular Genetics, Isfahan Medical University, Isfahan, Iran 4Molecular Genetic Center, Isfahan Forensic Center, Isfahan, Iran 5Legal Medicine Research Center, Tehran, Iran 6Systems Biology, University of Ferdowsi, Mashhad, Iran Received May 25, 2015 Accepted December 10, 2015 Abstract The objective of present study was to compare genetic structure of seven Iranian provinces and to understand the genetic relationship among these seven provinces (Isfahan, Fars, Hormozgan, Kerman, Chaharmahal & Bakhtiari, Kohgiluyeh & Boyer Ahmad, and Yazd). For this purpose, a set of 15 STR’s loci were investigated. This panel of STRs is standard forensic science genetic testing tool that we added some importance to them by putting them in genetic variation analysis. The results based upon Fisher exact test for Hardy-Weinberg equilibrium (HWE) indicated that the allele and genotype distributions were in accordance with Hardy- Weinberg expectations except for D16S539. From genetic diversity point of view, D2S1338 was among the best STR loci and Isfahan has the highest value in aspect of these indices. Our results indicated that high amount of gene flow have been from Isfahan to Fars, which should be further investigated. Also, we indirectly shown that those forensic motivated genetic markers could be used as reliable tool for genetic differentiation when sounds data are available. We did not mean to estimate forensic science specific measures e.g.
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