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Evidence Studies for Tea Tree Evidence Studies for Tea Tree Oil The Benefi ts of Cleansing with FungaSoap® Evidence Authors & Journal Article Title Area Instructions J Hosp Infect (England), Nov 2000, Tea tree oil as an alternative topical Caelli M, Porteous J, Carson Anti Bacterial 46(3) p236-7 decolonization agent for methicillin-resistant CF, et al. Staphylococcus aureus. J Antimicrob Chemother (England), Time-kill studies of tea tree oils on clinical May J, Chan CH, King A, et al. May 2000, 45(5)p639-43 isolates. J Appl Microbiol (England), Jan 2000, The mode of antimicrobial action of the Cox SD, Mann CM, Markham 88(1) p170-5 essential oil of Melaleuca alternafolia (tea JL, et al. tree oil). Oral Microbiol Immunol (Denmark), Susceptibility of oral bacteria to Melaleuca Hammer KA, Dry L, Johnson Dec 2003, 18(6)p389-92 alternifolia (tea tree) oil in vitro. M, et al. J Microbial Methods (Netherlands), Leakage of K+ ions from Staphylococcus Hada T, Inoue Y, Shiraishi A, Jun 2003, 53(3)p309-12 aureus in response to tea tree oil. et al. Antimicrob Agents Chemother Mechanism of action of Melaleuca alternifolia Carson CF, Mee BJ, Riley TV (United States), June 2002, 46(6) (tea tree) oil on Staphylococcus aureus p1914-20 determined by time-kill, lysis, leakage, and saltll tolerance assays and dl electron microscopy. J Am Podiatr Med Assoc (United 1998 William J. Stickel Bronze Award. Concha JM, Moore LS, States), Oct 1998, 88(10) p489-92 Antifungal activity of Melaleuca Alternifolia Holloway WJ Anti Fungal (tea tree) oil against various pathogenic organisms. Antimicrob Agents Chemother In vitro activities of ketoconazole, econazole, Hammer KA, Carson CF, (United States), Feb 2000, 44(2) miconazole, and Melaleuca alternafolia (tea Riley TV p467-9 tree) oil against Malassezia species. J Antimicrob Chemother (England), In vitro and in vivo activity of tea tree oil Mondello F, De Bernardis F, May 2003, 51(5) p1223-9 against azole-susceptible and - resistent Girolamo A, et al. human pathogenic yeasts. Lett Appl Microbiol (England), 2003, Antimycotic activity of Melaleuca alternalfolia Oliva B, Piccirilli E, Ceddia T, 37(2) p185-7 essetial oil and its major components. et al. J Appl Microbiol (England), 2003, Antifungal activity of the components of Hammer KA, Carson CF, 95(4)p853-60 Melaleuca alternifolia (tea tree) oil. Riley TV J Am Acad Dermatol (United States), Treatment of dandruff with 5% tea tree oil Satchell AC, Saurajen A, Bell Dec 2002, 47(6)p852-5 shampoo. C, et al. Australas J Dermatol ((),gAustralia), Aug Treatment of interdiggpital tinea pedis with 25% % Satchell AC,,j, Saurajen A, Bell 2002, 43(3) p175-8 and 50% tea tree oil solution; a randomized, C, et al. placebo-controlled, blinded study. J Antimicrob Chemother (England), In vitro activity of Melaleuca alternifolia (tea Hammer KA, Carson CF, Aug 2002, 50(2) p195-9 tree) oil against dermatophytes and other Riley TV filamentous fungi. Schwelz Arch Tierhelikd Antifungal effect of Australian tea tree oil on Weseler A, Geiss HK, Saller (Switzerland), May 2002, 144(5) Malassezia pachydermatis isolated from R, et al. p215-21 canines suffering from cutaneous skin disease. Anti Infective J Pharm Pharmacol (England), Mar Inhibition of acetylcholinesterase by Tea Tree Mills C, Cleary BJ, Gilmer JF, Scabicide 2004, 56(3) p375-9 oil. et al. Arch Dermatol (United States), May Acaricidal activity of Melaleuca alterifloia (tea Walton SF, McKinnon M, 2004, 140(5) p563-6 tree) oil: in vitro sensitivity of sarcoptes Pizzutto S, et al. scabiei var hominis to terpinen-4-ol. Inflamm Res (Switzerland), Nov Terpinen-4-ol, the main component of the Hart PH, Brand C, Carson CF, Anti 2000, (49)11 p619-26 essential oil of Melaleuca alternifolia (tea tree et al. Inflammatory oil), suppresses inflammatory mediator production by activated human monocytes. Inflamm Res (Switzerland), June Tea tree oil reduces histamine-induced Brand C, Townley SL, Finlay- 2002, 51(6)p283-9 oedema in murine ears. Jones JJ, et al. Inflamm Res (Switzerland), May Tea tree oil reduces the swelling associated Brand C, Grimbaldeston MA, 2002, 51(5) p236-44 with the efferent phase of a hypersensitivity Gamble JR, et al. response. Br J Dermatol (England), Dec 2002, Tea tree oil reduces histamine-induced skin Koh KJ, Pearce AL, 147(6)p1212-7 inflammation. Marshman G, et al. J Invest Dermitol (United States), Terpinen-4-ol, the main component of Calcabrini A, Stringaro A, Anti Neo Plastic Feb 2004, 122(2) p349-60 Melaleuca alternifolia (tea tree) oil inhibits the Toccacieli L, et al. in vitro growth of human melanoma cells. Pharmazie (Germany), Apr 2001, Antiviral activity of Austrailian tea tree oil and Schnitzier P, Schon K, Anti Viral 56(4) p343-7 eucalyptus oil against herpes simplex virus in Reichling J cell culture. J Antimicrob Chemother (England), Melaleuca alternifolia (tea tree) oil gel (6%) Carson CF, Ashton L, Dry L, Sep 2001, 48(3) p450-1 for the treatment of recurrent herpes labialis. et al. For more information contact: PediFix Footcare Products 310 Guinea Road Brewster, NY 10509 ® 1-800-424-5561 The Most Trusted Family in Footcare, Since 1885 visit: www.pedifi x.com.
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    ORIGINAL RESEARCH Periodontics Antibiofilm efficacy of tea tree oil and of its main component terpinen-4-ol against Candida albicans Renata Serignoli Abstract: Candida infection is an important cause of morbidity FRANCISCONI(a) and mortality in immunocompromised patients. The increase in its Patricia Milagros Maquera incidence has been associated with resistance to antimicrobial therapy HUACHO(a) and biofilm formation. The aim of this study was to evaluate the Caroline Coradi TONON(a) efficacy of tea tree oil (TTO) and its main component – terpinen-4-ol – Ester Alves Ferreira BORDINI(a) against resistant Candida albicans strains (genotypes A and B) identified by molecular typing and against C. albicans ATCC 90028 and SC 5314 Marília Ferreira CORREIA(a) reference strains in planktonic and biofilm cultures. The minimum Janaína de Cássia Orlandi inhibitory concentration, minimum fungicidal concentration, and SARDI(b) rate of biofilm development were used to evaluate antifungal activity. Denise Madalena Palomari Results were obtained from analysis of the biofilm using the cell (a) SPOLIDORIO proliferation assay 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H- tetrazolium-5-carboxanilide (XTT) and confocal laser scanning (a) Universidade Estadual Paulista – Unesp, microscopy (CLSM). Terpinen-4-ol and TTO inhibited C. albicans School of Dentistry of Araraquara, Department of Physiology and Pathology, growth. CLSM confirmed that 17.92 mg/mL of TTO and 8.86 mg/mL Araraquara, SP, Brazil of terpinen-4-ol applied for 60 s (rinse simulation) interfered with (b) Universidade Estadual de Campinas – biofilm formation. Hence, this in vitro study revealed that natural Unicamp, School of Dentistry of Piracicaba, substances such as TTO and terpinen-4-ol present promising results Department of Physiological Sciences, for the treatment of oral candidiasis.
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