Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma
Author Manuscript Published OnlineFirst on June 16, 2020; DOI: 10.1158/1078-0432.CCR-19-3874 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. RESEARCH ARTICLE Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma Authors: Erik Ladomersky1, Lijie Zhai1, Kristen L. Lauing1, April Bell1, Jiahui Xu2, Masha Kocherginsky2, Bin Zhang3,4, Jennifer D. Wu5, Joseph R. Podojil4, Leonidas C. Platanias3,6, Aaron Y. Mochizuki7, Robert M. Prins8, Priya Kumthekar9, Jeffrey J. Raizer9, Karan Dixit9, Rimas V. Lukas9, Craig Horbinski1,10, Min Wei11, Changyou Zhou11, Graham Pawelec12, Judith Campisi13,14, Ursula Grohmann15, George C. Prendergast16, David H. Munn17, Derek A. Wainwright1,5,7,8 Affiliations: 1Department of Neurological Surgery, 2Department of Preventive Medicine-Biostatistics, 3Department of Medicine-Hematology/Oncology, 4Department of Microbiology- Immunology, 5Department of Urology, 6Department of Biochemistry and Molecular Genetics, 9Department of Neurology, 10Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, USA. 7Department of Neurology and Neurological Sciences, Stanford University, Stanford, USA. 8Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA. 11BeiGene, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, China. 12Department of Immunology, University of Tübingen, Tübingen, Germany. 13Buck Institute for Research on Aging, Novato, CA, USA. 14Lawrence Berkeley National Laboratory, Berkeley, CA, USA. 15Department of Experimental Medicine, University of Perugia, Perugia, Italy. 16Lankenau Institute for Medical Research, Wynnewood, PA, USA. 17Georgia Cancer Center, Augusta, GA, USA. Running Title: Aging and brain immunosuppression of GBM immunity Keywords: Senescence, neuroimmunology, immunotherapy, brain tumor, IDO COI: Min Wei and Changyou Zhou possess financial interests and are paid employees of BeiGene, Ltd.
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