(12) United States Patent (10) Patent No.: US 7,972,785 B2 Hsieh Et Al
US00797 2785B2 (12) United States Patent (10) Patent No.: US 7,972,785 B2 Hsieh et al. (45) Date of Patent: Jul. 5, 2011 (54) BIOMARKERS FOR LIVER FIBROTIC Yi-Chao, Hsu, et al., “Increases in fibrosis-related gene transcripts in INJURY livers of dimethylnitrosamine-intoxicated rats.” J. Biomed Sci. 11:408-417 (2004). Shackel, Nicholas A. et al., “Gene array analysis and the liver.” (75) Inventors: Hui-Chu Hsieh, Changhua (TW); Hepatology, 36(6):1313-1325 (2002). Tzu-Ling Tseng, Chiayi (TW); Li-Jen Utsunomiya, Tohru, et al., “A gene-expression signature can quantify Su, Chiayi (TW); Chi-Ying Huang, the degree of hepatic fibrosis in the rat.” Journal of Hepatology, 41:399-406 (2004). Taipei (TW); Shih-Lan Hsu, Taipei Imaoka, Susumu, et al., “Localization of rat cytochrome P450 in (TW) various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs.” Drug Metab. (73) Assignees: Industrial Technology Research Pharmacokinet, 2006)478-484 (2005). Institute (ITRI), Hsinchu (TW); Wong, V. S., et al., "Serum hyaluronic acid is a useful marker of liver National Health Research Institutes fibrosis in chronic hepatitis C virus infection.” Journal of viral Hepa titis, 5:187-192 (1998). (NHRI), Miaoli County (TW) Ala-Kokko, L., et al., “Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat.” (*) Notice: Subject to any disclaimer, the term of this Biochem. J. 244:75-79 (1987). patent is extended or adjusted under 35 Arthur, M.J.P. et al., “Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis,” J.
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