[(4-Chlorophenyl)Sulfonyl] Benzoic Acid Derivatives
molecules Article Synthesis, In Silico and In Vitro Evaluation of Antimicrobial and Toxicity Features of New 4-[(4-Chlorophenyl)sulfonyl]benzoic Acid Derivatives Theodora-Venera Apostol 1 , Mariana Carmen Chifiriuc 2 , Constantin Draghici 3, Laura-Ileana Socea 1 , Luminita Gabriela Marutescu 2,*, Octavian Tudorel Olaru 1,*, George Mihai Nitulescu 1 , Elena Mihaela Pahontu 1, Gabriel Saramet 1 and Stefania-Felicia Barbuceanu 1 1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania; theodora.apostol@umfcd.ro (T.-V.A.); laura.socea@umfcd.ro (L.-I.S.); george.nitulescu@umfcd.ro (G.M.N.); elena.pahontu@umfcd.ro (E.M.P.); gabriel.saramet@umfcd.ro (G.S.); stefania.barbuceanu@umfcd.ro (S.-F.B.) 2 Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 60101 Bucharest, Romania; carmen.chifiriuc@bio.unibuc.ro 3 “Costin D. Nenit, escu” Centre of Organic Chemistry, Romanian Academy, 202 B Splaiul Independent, ei, 060023 Bucharest, Romania; cst_drag@yahoo.com * Correspondence: luminita.marutescu@bio.unibuc.ro (L.G.M.); octavian.olaru@umfcd.ro (O.T.O.) Abstract: The multi-step synthesis, physico-chemical characterization, and biological activity of Citation: Apostol, T.-V.; Chifiriuc, novel valine-derived compounds, i.e., N-acyl-α-amino acids, 1,3-oxazol-5(4H)-ones, N-acyl-α-amino M.C.; Draghici, C.; Socea, L.-I.; ketones, and 1,3-oxazoles derivatives, bearing a 4-[(4-chlorophenyl)sulfonyl]phenyl moiety are re- Marutescu, L.G.; Olaru, O.T.; ported here. The structures of the newly synthesized compounds were confirmed by spectral (UV-Vis, Nitulescu, G.M.; Pahontu, E.M.; FT-IR, MS, 1H- and 13C-NMR) data and elemental analysis results, and their purity was determined Saramet, G.; Barbuceanu, S.-F.
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