Utilization of Complementary and Alternative Medicine
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Italia et al. BMC Complementary and Alternative Medicine (2015) 15:49 DOI 10.1186/s12906-015-0569-8 RESEARCH ARTICLE Open Access Utilization of complementary and alternative medicine (CAM) among children from a German birth cohort (GINIplus): patterns, costs, and trends of use Salvatore Italia1,2*,HelmutBrand1, Joachim Heinrich3,DietrichBerdel4, Andrea von Berg4 and Silke Britta Wolfenstetter2 Abstract Background: The use of complementary and alternative medicine (CAM) is widespread among children in Germany and other European countries. Only a few studies are available on trends in pediatric CAM use over time. The study’s objective was to present updated results for prevalence, predictors, and costs of CAM use among German children and a comparison with findings from a previous follow-up of the same birth cohort. Methods: Data were collected for 3013 children on their utilization of medicinal products (during the last 4 weeks) and consultation with CAM providers (in the preceding year) from a German birth cohort study (GINIplus, 15-year follow-up) using a self-administered questionnaire. The reported medicinal CAMs were classified into six categories (homeopathy, herbal drugs, nutritionals, minerals and trace elements, microorganisms, further CAM). Drug prices were traced using pharmaceutical identification numbers (PZNs), or otherwise conservatively estimated. Finally, the results were compared with data obtained from the 10-year follow-up of the same birth cohort study by adopting the identical methodology. Results: In all, 26% of the reported 2489 drugs were medicinal CAM. The 4-week prevalence for homeopathy and herbal drug use was 7.5% and 5.6%, respectively. Some 13.9% of the children used at least one type of medicinal CAM in the preceding 4 weeks. The 1-year prevalence for consultation with CAM providers was 10.8%. From the drugs identified as CAM, 53.7% were homeopathic remedies, and 30.8% were herbal drugs. Factors associated with higher medicinal CAM use were female gender, residing in Munich, and higher maternal education. A homeopathy user utilized on average homeopathic remedies worth EUR 15.28. The corresponding figure for herbal drug users was EUR 16.02, and EUR 18.72 for overall medicinal CAM users. Compared with the 10-year follow-up, the prevalence of homeopathy use was more than halved (−52%) and dropped substantially for herbal drug use (−36%) and overall CAM use (−38%) as well. (Continued on next page) * Correspondence: [email protected] 1Department of International Health, School for Public Health and Primary Care (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands 2Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Neuherberg, Germany Full list of author information is available at the end of the article © 2015 Italia et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Italia et al. BMC Complementary and Alternative Medicine (2015) 15:49 Page 2 of 10 (Continued from previous page) Conclusion: CAM use among 15-year-old children in the GINIplus cohort is popular, but decreased noticeably compared with children from the same cohort at the age of 10 years. This is possibly mainly because German health legislation normally covers CAM for children younger than 12 years only. Keywords: Complementary therapies, CAM, Homeopathy, Phytotherapy, Child, Germany, Drug utilization, Socioeconomic factors, Trends Background Methods Therapy approaches that are not part of conventional medi- Study population cine are often referred to as complementary and alternative GINIplus (German Infant study on the Influence of Nutri- medicine (CAM), although there is no universally valid def- tion Intervention plus environmental and genetic influ- inition of CAM. However, there seems to be an unbroken ences on allergy development) is a German birth cohort high demand for such kinds of therapy approaches in the study [11]. It started with 5991 healthy full-term newborns European population and outside Europe as well. Some re- (children with a birth weight <2500 g were not eligible for cently published reviews give updated overviews on the inclusion), who were recruited between September 1995 prevalence of CAM use in adults [1,2] and children [3,4]. and June 1998 from obstetric clinics in an urban region of Owing to different methodology and CAM definition, the southern Germany (Munich) and a more rural region in findings of the included studies on CAM use vary the western part of Germany (Wesel). widely with respect to the prevalence and predictors of For the 15-year follow-up, 3895 participants were con- use. For instance, overall CAM use in children without tacted between January 2011 and September 2013. With re- chronic conditions was reported to be between 1.8% and gard to the season, 27% of the questionnaires were collected 87.6%, depending on included CAM modalities, country, in winter (January–March), 29% in spring (April–June), 26% and underlying recall period [3]. in summer (July–September), and the remaining 18% in au- When looking at specific CAM categories, many of tumn (October–December). Among other things, the the reviewed studies listed homeopathy and herbal drugs main questionnaire assessed the children’s gender, parental among the most popular types of CAM. Within Europe, income and education, and consultation with various alter- Germany ranks between the countries with the highest native health care providers during the previous 12 months. prevalence rates for homeopathy and herbal drug use in In addition to the main questionnaire, a self-adminis- children. For homeopathy, prevalence rates of 27.7% tered questionnaire on the consumption of drugs and (1-year prevalence) [5] and 14.3% (4-week prevalence) medicinal products was included based on an almost [6] were reported in German children. Other European identical questionnaire that had already been adopted countries with high prevalence rates for homeopathy use for the 10-year follow-up. The design of the question- are The Netherlands with 14.6% (1-year prevalence) [7] naire on drug utilization corresponds to the validated and the UK with 16.9% (lifetime use) [8]. With concern to questionnaire from the German KiGGS-Study that was herbal drugs, a 2010 publication found 85.5% of German conducted with 17641 children [12]. Parents/legal guard- children [9] using herbal drugs (lifetime use). In Turkey, ians were invited to report the drugs their child used dur- the prevalence of pediatric use of herbal drugs was 58.6% ing the last 4 weeks by entering the drugs’ names into (1-year prevalence) [10]. The evidently high popularity of designated spaces or attaching the empty drug packages to non-conventional medicine in Germany and other coun- the questionnaire. tries makes CAM use a relevant public health topic. The exact number of drugs used was assessed by an add- This article presents data from the recently completed itional question in case the limited number (five) of desig- 15-year follow-up of a German birth cohort study. The aim nated spaces would not suffice to report all drugs utilized. was to extract prevalence rates and predictors for the Moreover, the participants were also asked to enter utilization of various CAM modalities (homeopathy use, the pharmaceutical identification number (PZN) of the herbal drug use, medicinal CAM utilization in general, and reported drugs. The PZN, which is printed on the drug consultation with CAM providers). Furthermore, expendi- package, precisely identifies the drug utilized and pro- tures on pediatric CAM use were analyzed. Finally, in order vides further information such as the size of the package, to detect possible time trends and differences in CAM use, the dosage, the pharmaceutical manufacturer, the listed the results were compared with the findings from the 10- price, etc. year follow-up of a smaller but similarly composed sample To avoid ambiguity of interpretation, the authors fromthesamebirthcohort. would like to note that we also considered preparations Italia et al. BMC Complementary and Alternative Medicine (2015) 15:49 Page 3 of 10 that are no medicinal products in the strict sense (e.g., area, maternal educational background, and parental in- nutritional supplements), but were reported as drugs come background was very similar to the composition of utilized by the participating children. the GINIplus cohort of the 15-year follow-up (n = 3013). Furthermore, the same methodology (drug classification, Drug classification logistic regression model, etc.) was adopted for the analysis All reported drugs were classified into several therapeutic of both follow-ups. categories. The following medicinal CAM modalities were defined and extracted from the entity of reported drugs: Outcome definition and statistical analysis (1) Homeopathic/anthroposophic drugs (afterwards Several outcomes were defined for the statistical analysis. referred to as ‘Homeopathy’): Drugs that have been Those participants who reported utilization