11th International Multiconference «Bioinformatics of Genome Regulation and Structure\ Systems Biology», Novosibirsk, Russia, 20 - 25 August 2018 BGRS\SB-2018 MM&HPC-BBB-2018 SBioMed-2018 CSGB-2018

BioGenEvo-2018 SbPCD-2018 FCRW-2018

20 August 08:30-10:00 Registration (House of Scientists SB RAS, main entrance) Coffee-break 10.10–17.30 Plenary session (House of Scientists SB RAS, Large hall) Chairpersons: Prof. Nikolay Kolchanov, Prof. Ralf Hofestädt, Prof. Mikhail Fedoruk 10.10-10.30 Opening Ceremony (House of Scientists SB RAS, Large Hall) 10.30–11.10 Entropic hourglass patterns of animal and plant development and the emergence of biodiversity. Ivo Grosse, Institute of Computer Science, Martin Luther University Halle-Wittenberg, Halle, Germany 11.10–11.50 Selection versus Adaptation: Network Diversification and the Origins of Life, Ageing and Cancer Hans V. Westerhoff, Synthetic Systems Biology and Nuclear Organization, University of Amsterdam 11.50–12.30 Unraveling of gene expression control in genome-reduced bacteria. The rally goes on… Vadim Govorun, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (RCC PCM FMBA), Russia 12.30–12.45 HPC clusters and Big Data storage for data analysis in scientific research – Huawei experience Alexey Iyudin, Huawei Technologies, Gold Sponsor 12.45–14.30 Lunch + Registration 14.30–15.10 Towards understanding of apoptosis regulation using computational biology Inna N. Lavrik, Department of Translational Inflammation Research, Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany; Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia 15.10–15.50 Biological resources as the sources and limits of human society development (from photosynthesis to electrosynthesis) Nikolay Yankovsky, Vavilov Institute of General Genetics of Russian Academy of Sciences, , Russia 15.50-16.10 Coffee-break 16.10–16.50 Multiple Origins and Evolution of Neurons and Brains through the lens of single cell genomics Leonid Moroz, University of Florida, Florida, USA

16.50–17.30 NSU Mikhail Fedoruk, Novosibirsk State University, Novosibirsk, Russia 18.00-18.40 Сoncert 19.00 Dinner Banquet SECTION «Systems Computational Biology» 21 August, Tuesday

Chairs: - Prof. Dr. H.V. (Hans) Westerhoff, University of Amsterdam, Amsterdam, Netherlands - Dr Matteo Barberis, University of Amsterdam, Amsterdam, Netherlands - Maria Samsonova, Peter the Great St.Petersburg Polytechnic University

Oral reports:

9:00 - 9:35 Control and Regulation: limits to what the genome may achieve Hans V. Westerhoff Synthetic Systems Biology and Nuclear Organization, University of Amsterdam; Molecular Cell Physiology, Vrije Universiteit Amsterdam; Systems Biology, The University of Manchester Infrastructure Systems Biology Europe. NL 9:35 - 10:00 The “transformer” model of ROS management for PD and cancer: Network diversification as the source of precision in blue-print modelling Alexey Kolodkin1, 2, 3, 4, 5*, A.M. Colangelo6, L. Alberghina6, R.P. Sharma7 , V. Kumar7 , D. Jennen8, J.J. Briede8, H.V. Westerhoff 1, 4, 5, 9 1 Infrastructure for Systems Biology Europe (ISBE); 2 Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg; 3 Federal Centre Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences, Russia; 4 Molecular Cell Physiology, VU University Amsterdam, The Netherlands; 5 Synthetic Systems Biology, SILS, University of Amsterdam, The Netherlands; 6 SysBio Centre of Systems Biology, University of Milano-Bicocca, Italy; 7 Center of Environmental Food and Toxicological Technology (TecnATox), Departament d’Enginyeria Química, Universitat Rovira i Virgili, Spain; 8 Department of Toxicogenomics, Maastricht University, The Netherlands; 9 Manchester Centre for Integrative Systems Biology, UK 10:00 - 10:25 CRISPR-Cas regulation: a systems biology approach Marko J. Djordjevic1*, A. Rodic1, B. Blagojevic2, M. R. Djordjevic2, K Severinov3 1 Faculty of Biology, Institute of Physiology and Biochemistry, University of Belgrade, Serbia; 2Institute of Physics Belgrade, University of Belgrade, Serbia; 3Skolkovo Institute of Science and Technology, Moscow, Russia 10:25 - 10:50 Petri-net-Framework: Modeling and simulation of biological networks based on Petri nets Ralf Hofestädt and C. Brinkrolf AG Bioinformatics and Medical Informatics University Bielefeld, Technical Faculty, Germany 10:50 - 11:10 Coffee break

11:10 - 11:45 Deciphering Cell’s Robustness by a Multi‐Scale Framework Integrating Cell Cycle and Metabolism in Yeast L. van der Zee, T.D.G.A. Mondeel, H. Westerhoff, Matteo. Barberis Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands 11:45 - 12:10 Reconstruction of whole-genome metabolic model of Atlantic salmon Salmo salar (SALARECON) Maksim Zakhartsev, J. O. Vik, F. Grammes Norwegian University of Life Sciences, Ås, Norway 12:10 - 12:35 Mathematical modeling of formation and supporting of the structure of the root apical meristem Arabidopsis thaliana L. Lavrekha Viktoriya.V., Mironova V.V. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 2 Novosibirsk State University, Novosibirsk, Russia 12:35 - 13:00 FAIRDOMHub: a repository and collaboration environment for sharing systems biology research Olga Krebs1, K. Wolstencroft2, J. L. Snoep3, N.J. Stanford4, F. Bacall4, M. Golebiewski1, S. Owen4, A.R. Williams4, W. Mueller1 and C. Goble4 1HeidelbergInstitute for Theoretical Studies, Heidelberg, Germany; 2Leiden Institute of Advanced Computer Science,Netherlands; 3University of Stellenbosch, South Africa; 4School of ComputerScience, The University of Manchester, UK 13:05 - 15:00 Lunch

15:00 - 15:35 3D multiscale hybrid modeling and simulation of vascular tumour growth including spatio-temporal distribution of central metabolism Matthias Reuss, A. Lapin Stuttgart Research Center Systems Biology, University Stuttgart Germany 15:35 - 16:00 Comparison of High- and Low-resolution MS Data for Direct Tissue Profiling on a Way from Laboratory to Clinic Anatoly Sorokin1*, V. Shurhkhay1, 3, K. Bocharov1, 2, I. Popov1, 2, 4, E. Zhvansky1, A. Potapov3, E. Nikolaev1, 2, 5 1 Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia; 2 Institute of Energy Problems of Chemical Physics of RAS, Moscow, Russia; 3 N. N. Burdenko Scientific Research Neurosurgery Institute, Moscow, Russia; 4 Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia; 5 Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, Russia 16:00 - 16:20 ADAPTIVE STRATEGIES OF MOTILE BACTERIA IN DYNAMIC AQUATIC ECOSYSTEMS. A SIMULATION STUDY Alexandra I. Klimenko, Yu.G. Matushkin, S.A. Lashin Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia 16:20 - 16:40 Evolutionary Computations and Modular Organization of the Gene Regulatory Regions Alexandr Spirov1, E. Myasnikova2 1 I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia; 2 Peter the Great St. Petersburg Polytechnical University, St. Petersburg, Russia 16:40 - 17:00 On evolutionary analysis of gene networks by the Orthoscape software Zahar S. Mustafin1, D.A. Afonnikov1,2, Yu.G. Matushkin1,2, S.A. Lashin1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 17:00 - 17:10 Coffee break

17:10 - 17:40 Natural selection equally supports the human bias in subordination and domination: a genome-wide study with in silico confirmation and in vivo validation in mice

I.V. Chadaeva1,2, L. K. Savinkova1, P. M. Ponomarenko3, Mikhail P. Ponomarenko1,2,* , D. A. Rasskazov1, E. B. Sharypova1, E. Kashina1, M. Kleschev, V. Naumenko, N. Kolchanov1, L. Osadchuk, A. Osadchuk 1 - Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; 2 - Novosibirsk State University, Novosibirsk; 3 - University of La Verne, La Verne, USA 17:40 - 18:20 Prediction of deleterious mutations with Transfer learning E. Plekhanova, S.V. Nuzhdin, L. Utkin, Maria G. Samsonova Peter the Great St.Petersburg Polytechnic University, St.Petersburg, Russia 18:20 - 18:45 Development of nonlinear regression models of flowering time control by climatic factors in soybean and chickpea Konstantin K. Kozlov1, L. Novikova1, 2, I. Seferova2, S. Nuzhdin1,3 and M. Samsonova1 1 Peter the Great St..Petersburg Polytechnic University, St.Petersburg, Russia; 2 Federal Research Center the N. I. Vavilov All-Russian Institute of Plant Genetic Resources, St.Petersburg, Russia; 3 University of Southern California, Los Angeles, CA, USA 18:45 - 19:05 Prediction Of Gene Expression Level By Using ChIP-Seq-Derived Data From The GTRD Database And Transcription Start Sites Identified By The Fantom5 Project I. Yevshin1, Yu. Kondrakhin1,2, Ruslan Sharipov1,3, F. Kolpakov1,2 1 BIOSOFT.RU, Ltd, Novosibirsk, Russia; 2 Institute of Computational Technologies SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 19:05 - 19:30 Patterns and models of flowering of some Campanulaceae Juss. species Eduard Fomin1*, T. Fomina2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Central Siberian Botanical Garden SB RAS, Novosibirsk, Russia

SECTION «Systems Biology of Aging» 21 August, Tuesday

Chairs: Vladimir Anisimov, President of Gerontological society of the Russian Academy of Sciences, N.N. Petrov Research Institute of Oncology, Saint-Petersburg, Russia Natalya Kolosova, Institute of Cytology and Genetics of SB RAS Elena Pasyukova, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

Oral reports:

Chairs M. Kulminski, Е.G.Pasyukova

9:00 - 9:40 Molecular signatures of Alzheimer’s disease and aging in the TOMM40-APOE- APOC1 locus Alexander M. Kulminski, L. Shu, Y. Loika, and I. Culminskaya Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, USA 9:40 - 10:20 Plasmid encoding p62/SQSTM is a novel biological agent against diseases of chronic inflammation and age-associated disorders Alexander Shneider CureLab Oncology Inc 10:20 - 10:45 Longevity in Mammals: Lost Genes As a Determinant Alexandr V. Seliverstov1, G.A. Shilovsky2, L.I. Rubanov1, O.A. Zverkov1, V.A. Lyubetsky1, 2 1 Institute for Information Transmission Problems of the Russian Academy of Sciences (Kharkevich Institute), Moscow, Russia; 2 Lomonosov , Moscow, Russia 10:45 - 11:10 Coffee-break 11:10 - 11:35 Influence of Insertion/Deletion and Transcriptional Activity of Alu-Elements on Human Longevity Vera Erdman, D. Karimov, T. Nasibullin, I. Tuktarova, O. Mustafina Institute of Biochemistry and Genetics, Ufa Federal Innovation Center, Russian Academy of Sciences 11:35 - 12:00 Reduced Expression of shaggy, the Gene Encoding Protein Kinase GSK3, in Dopaminergic Neurons Increases Drosophila melanogaster Lifespan Ekaterina R. Veselkina1, M. V. Trostnikov1,2, A. V. Krementsova1,3, N. V. Roshina1,2, E. G. Pasyukova1 1 Institute of Molecular Genetics of RAS, Moscow, Russia; 2 Vavilov Institute of General Genetics of RAS, Moscow, Russia; 3 Emmanuel Institute of Biochemical Physics of RAS, Moscow, Russia 12:00 - 12:25 Is Retardation of Development of Retina and Brain a Predictor of Age-related Macular Degeneration and Alzheimer’s disease? Natalia A. Stefanova, O.S. Kozhevnikova, D.V. Telegina, N.G. Kolosova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 13:05 - 15:00 Lunch and Poster Session Chairs Alexander Shneider, Joshi Peter

15:00 - 15:40 Systems biology of Aging: Genomic basis of human lifespan - diseases not aging? P. RHJ Timmers1, N. Mounier2,3, K. Läll4,5, K. Fischer4, Z. Ning6, X. Feng7, A. Bretherick8, D. W Clark1, X. Shen1,6, T. Esko4, Z. Kutalik2,3, J. F Wilson1,8, Peter K Joshi1,2 1 Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom; 2 Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland; 3 Swiss Institute of Bioinformatics, Lausanne, Switzerland 4 Estonian Genome Center, University of Tartu, Tartu, Estonia ; 5 Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia; 6 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7 State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, School of Life Sciences, Sun Yat-sen University, Guangzhou, China; 8 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, United Kingdom 15:40 - 16:25 Molecular and Cellular Mechanisms of Age-Related Macular Degeneration: Evidences from OXYS Rats D.V. Telegina, A.Z. Fursova, Oyuna S. Kozhevnikova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 16:20 - 16:45 The Influence of Environmental and Social Factors on the Parameters Dynamics of the Gompertz Function Anna V. Krementsova Emanuel Institute of Biochemical Physics, RAS, Moscow, Russia 16:50 - 17:10 Coffee-break 17:10 - 17:35 Systems Biology Approach Reveals the Mystery of Aging Origin Alexander Khalyavkin1, 2, V. Krut’ko2, 3 1 Emanuel Institute of Biochemical Physics RAS, Moscow, Russia; 2 Institute for Systems Analysis FRC CSC RAS, Moscow, Russia; 3 Sechenov First Moscow State Medical University, Moscow, Russia 17:35 - 18:00 Expression of Neurogenesis-Associated Genes during Development of Alzheimer’s Disease-Like Pathology in OXYS Rats Ekaterina A. Rudnitskaya, N.G. Kolosova, N.A. Stefanova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

SECTION «Genomics, transcriptomics and bioinformatics» 21, 24 August

Chairs: Ivo Grosse, Halle-Wittenberg University, Halle, Germany Vsevolod Makeev, VIGG RAS, MIPT, Moscow, Russia Yurii Aulchenko, Novosibirsk State University, ICG SB RAS, PolyOmica, UoE

Oral reports:

21 August Morning session 1. Genomics, transcriptomics and regulation 9:00 – 9:30 Fast and exhaustive annotation of motif co-occurrence with regard to their overlapping status in ChIP-seq data

Viktor G. Levitsky1,2*, D.Yu. Oshchepkov1, E.V. Zemlyanskaya1,2, V.V. Mironova1,2, E.V. Ignatieva1,2, O.A. Podkolodnaya1, T.I. Merkulova1,2, , Ivo Grosse2,3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3Martin-Luther University, Halle-Wittenberg, Germany 9:30 -9:50 Evolutionary analysis of 3-dimensional chromatin structure Miroslav Nuriddinov1, V. Fishman1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 9:50 – 10:10 Tandem repeats in mammalian genomes Dmitry Ostromyshenskii1*, O. Podgornaya1, 2 1 Institute of Cytology RAS, , Russia; 2 Saint Petersburg State University, Saint Petersburg, Russia 10:10 – 10:30 Genomics in analysis of Chlamydia psittaci host-adaptation Olga Voronina, M. Kunda, E. Aksenova, N. Sharapova, N. Ryzhova, N. Bondareva, N. Zigangirova N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russia 10:30 – 10:50 A novel approach to identify highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer Kanthida Kusonmano1,2,3, M. K. Halle2,4, E. Wik5,6, E. A. Hoivik2,4, C. Krakstad2,4, K. K. Mauland2,4, I. L. Tangen2,4, A. Berg2,4, H. M. J. Werner2,4, J. Trovik2,4, A.M. Øyan4,7, K.-H. Kalland4,7, I. Jonassen1,8, H. B. Salvesen2,4 and K. Petersen1 1 Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway; 2 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway; 3 Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkhuntien, , Thailand; 4 Center for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway; 5 Center for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway; 6 Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway; 7 Department of Microbiology, Haukeland University Hospital, Bergen, Norway; 8 Center for Cancer Biomarkers, Department of Informatics, University of Bergen, Bergen, Norway 10:50 - 11:10 Coffee break

Morning session 2. Gene expression and diseases

11:10 – 11:40 Adaptation and selective constraint throughout the Drosophila melanogaster life-cycle M. Coronado-Zamora1, I. Salvador-Martínez2,3, D. Castellano4, I. Salazar-Ciudad1 and Antonio Barbadilla1 1Genomics, Bioinformatics and Evolution. Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Spain ; 2EvoDevo Community, Centre of Excellence in Experimental and Computational Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland; 3Department of Genetics, Evolution and Environment. University College , United Kingdom; 4Bioinformatics Research Center, Aarhus University, Aarhus C, Denmark 11:40 – 12:00 Predicting pathological promoter-enhancer rewiring in chromosomal rearrangements Veniamin Fishman1,2, P. Belokopytova1,2, P. Salnikov1,2, D. Fishman2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 12:00 – 12:20 Bayesian modelling of gene network alterations during blood cells differentiation and cancerogenesis Anna A. Igolkina, M.G. Samsonova Peter the Great St. Petersburg Polytechnic University, Mathematical Biology and Bioinformatics Laboratory, St. Petersburg, Russia 12:20 – 12:50 Dynamically regulated miRNA-mRNA network in lymph node metastasis of prostate cancer patients Maksim Shkurnikov, E. Knyazev, D. Mikhailenko, A. Zotikov, B. Alekseev National Medical Research Radiology Center, Obninsk, Russia 12:50 – 13:10 10x Genomics/How to analyze transcriptome of each of 800 000 cells, using automatized library prep for Illumina from 10x Genomics Kermen Bolaeva SkyGen, Moscow, Russia, Silver Sponsor 13:10 - 15:00 LUNCH

Evening session 1: New Technologies

15:00 – 15:30 Design of genus-specific primer panel for detection and identification of viral DNA in environmental samples using next-generation sequencing Kamil Khafizov1,2, A.A. Ayginin1,2, E.V. Pimkina1, A.D. Matsvai1,2, A.S. Speranskaya1,3, M.V. Safonova1, E.A. Blinova1, I.V. Artyushin1,3, V.G. Dedkov1, G.A. Shipulin1 1 Central Research Institute of Epidemiology, Moscow, Russia; 2 Moscow Institute of Physics and Technology, Dolgoprudny, Russia; 3 Lomonosov Moscow State University, Moscow, Russia 15:30 – 15:45 The advanced technologies of Illumina for NGS Alexander Kilin Albiogen, Moscow, Russia, Silver Sponsor 15:45 – 16:15 Evaluation of MinION nanopore platform for HIV whole coding regions sequencing Speranskaya Anna S., Lopatukhin A.E., Khafizov K., Ayginin A.A., Korneenko E.V., Kireev D.E., Shipulin G.A. Central Research Institute of Epidemiology, Moscow, Russia 16:15 – 16:50 -Omics approaches to help decipher molecular control of root biotic interactions in the model legume Medicago truncatula Cécile Ben1*, M. Toueni1, M. Rickauer1, MIRMED consortium (PIs : M. Crespi2, L. Gentzbittel1, J. Gouzy3, A. Niebel3, C. Roux4), L. Gentzbittel1 1 EcoLab, Université de Toulouse, CNRS, Toulouse INP, UPS, Toulouse, France; 2 IPS2, Orsay, France; 3LIPM, Toulouse, France; 4 LRSV, Toulouse, France 16:50 - 17:10 Coffee break

17:10 – 17:40 Workflows for classification of NGS metagenomic data Dmitry Sukhomlinov1, 2, Y. Algaer2, A. Tiunov2, E. Pushkova2, O. Golosova2 1Novosibirsk State University, Novosibirsk, Russia; 2Unipro Center of Information Technologies, Novosibirsk, Russia 17:40 – 18:00 Analysis of biosynthetic gene clusters of Rhodococcus sp. S10 Alena Sorokina1, L. Shafigullina1, A. Elistratova1, M. Belenikin2, M. Sharipova1, L. Bogomolnaya1,3, I. Khilyas1 1 Institute of Fundamental medicine and biology KFU, Kazan, Russia;2 Department of molecular and biological physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia; 3 Texas A&M University Health Science Center, Bryan 77807, TX, USA 18:00 – 18:20 Genomes of Three Conifer Species: Larix sibirica, Pinus sibirica and Pinus sylvestris Yulia Putintseva1, V. Sharov1, D. Kuzmin1, N. Oreshkova1, 2, S. Feranchuk3, 4, V. Biryukov1, S. Novikova1, K. Miroshnikova1, S. Makolov1, M. Sadovsky1, K. Krutovsky1, 5, 6, 7 1 Siberian Federal University, Krasnoyarsk, Russia; 2V.N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3 National Research Technical University, Irkutsk, Russia; 4 Limnological Institute, SB RAS, Irkutsk, Russia; 5George-August University of Göttingen, Göttingen, Germany; 6Vavilov Institute of General Genetics RAS, Moscow, Russia; 7Texas A&M University, College Station, USA 18:20 – 18:40 Flax (Linum usitatissimum L.) Response to Non-Optimal Acidity and Zinc deficiency Alexey Dmitriev1, G. Krasnov1, A. Zyablitsin1, T. Rozhmina1,2, R. Novakovskiy1, P. Kezimana1, A. Kudryavtseva1, N. Melnikova1 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2 All-Russian Research Institute for Flax, Torzhok, Russia

24 August Morning session 1 9:00 - 9:40 Population genetic history the red-necked stint Fedor Kondrashov Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria 9:40 - 10:00 Selfish elements drive mitochondrial and nuclear genome size in opposite directions Alina A. Mikhailova1, A.G. Mikhaylova1, K. Ushakova1, D. Knorre2, I. Mazunin1, A. Reymond3, K. Gunbin1,4, K. Popadin1,3 1 School of Life Science, Immanuel Kant Federal Baltic University, Kaliningrad, Russia; 2 Belozersky Institute of Physico-Chemical Biology, Moscow State University , Russia; 3 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 4 Theoretical Dept., Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation 10:00 - 10:25 Determining the Pathogenicity of Genetic Variants Affecting Splicing in Mendelian Disorders Mikhail Skoblov1, 2, A. Marakhonov1, 2, Y. Vyakhireva1, P. Sparber1, V. Freire1, A. Filatova1 1 Research Center for Medical Genetics, Moscow, Russia ; 2 Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia 10:25 - 10:40 Search for a hidden structure in genomic data based on a compressing autoencoder Alexey Zarubin1,2, A. Markov1, V. Stepanov1, V. Kharkov1 1Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics, Tomsk, Russia ;2Siberian State Medical University, Tomsk, Russia 10:40 - 10:55 BD Rhapsody: technologies for quantitative analysis of transcriptome at the cellular populations and single cells levels Andrey Evteev BioLine, Moscow, Russia, Silver Sponsor 11:00 - 11:10 Coffee break

11:10 - 11:50 The Genomic Basis of Human Lifespan P. RHJ Timmers1, N. Mounier2,3, K. Läll4,5, K. Fischer4, Z. Ning6, X. Feng7, A. Bretherick8, D. W Clark1, X. Shen1,6, T. Esko4, Z. Kutalik2,3, J. F Wilson1,8, Peter K Joshi1,2 1 Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom; 2 Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland; 3 Swiss Institute of Bioinformatics, Lausanne, Switzerland; 4 Estonian Genome Center, University of Tartu, Tartu, Estonia ; 5 Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia; 6 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7 State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, School of Life Sciences, Sun Yat-sen University, Guangzhou, China; 8 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, United Kingdom

11:50 - 12:15 GENETIC REGULATION OF IMMUNOGLOBULIN G N- GLYCOSYLATION Lucija Klaric1, 2, Y. Tsepilov3, 13, M. Mangino4, T. Esko5, 6, 7, P. Salo8, S.J. McGurnaghan1, F. Vuckovic2, H.M. Colhoun1, 9, M. Dunlop10, M. Perola8, K. Fischer5, O. Polasek11, J. Wilson1, 12, T. Spector4, Y.S. Aulchenko3, 13, C. Hayward1, G. Lauc2, 14 1 Human Genetics Unit, Medical Research Council, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; 2 Genos Glycoscience Research Laboratory, Zagreb, Croatia; 3 Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia; 4 Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom; 5 Estonian Genome Center, University of Tartu, Tartu, Estonia; 6 Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, USA; 7 Division of Endocrinology, Boston Children's Hospital, Cambridge, USA; 8 Genomics and Biomarkers Unit, Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland; 9 Department of Public Health, NHS Fife, Kirkcaldy, United Kingdom; 10 Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; 11 Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia; 12 Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom; 13 Novosibirsk State University, Novosibirsk, Russia; 14 Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia 12:15 - 12:40 Exome-wide survey of the Siberian Caucasian population Andrey A. Yurchenko1, N.S. Yudin1,2, M.I. Voevoda1,3 1 The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Internal and Preventive Medicine – branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia 12:40 - 12:55 Mining Large Database of Genome-Wide Associations to Identify Biomarkers and Intervention Targets Tatiana I. Shashkova1,2,3, A.Torgasheva4, D.D.Gorev1,2,3, E.Pakhomov 2, L.Klaric5,6, A.V. Severinov1,3, S. Sharapov2,4, Y.A.Tsepilov2,4, D.G. Alexeev1,2, J.F. Wilson5, P. Joshi5, Y.S.Aulchenko2,4 1 LLC ‘Knomics’, Moscow, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Moscow Institute of Physics and Technology, Moscow, Russia; 4 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia;5 University of Edinburgh, Edinburgh, UK; 6 Genos Glycoscience Laboratory, Zagreb, Croatia 12:55 - 13:10 DNA\RNA sequencing with Oxford Nanopore devices E. Zonov Dia-m, Moscow, Russia Silver Sponsor 13:10 - 15:00 LUNCH

Evening session. 15:00 – 15:30 Profiling Neuronal Epigenomes in a Mouse Model of Alcohol Use Disorder C.R. Bridges, O. Ponomareva, C.T. Tulisiak, T. Larina, R.A. Harris, Igor Ponomarev Waggoner Center for Alcohol and Addiction Research, The University of Texas, Austin, Texas, USA 15:30 – 16:00 COMPARATIVE TRANSCRIPTOMICS OF THE EFFECTS OF PRIONIZATION AND INACTIVATION OF THE Swi1 PROTEIN IN Saccharomyces cerevisiae Kirill S. Antonets1,2, S.F. Kliver1,2, D.E. Polev1, A.R. Shuvalova1, E.A. Andreeva1,3, S.G. Inge-Vechtomov1,3, A.A. Nizhnikov1,2 1Laboratory for Proteomics of Supra-Organismal Systems, All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, Russia; 2Dept. of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia; 3Vavilov Institute of General Genetics Russian Academy of Sciences, St. Petersburg, Russia 16:00 - 16:30 Bioinformatics approach for prediction of metabolic capabilities for synthesis of essential vitamins and amino acids in human gut microbiome German A. Ashniev, A.A. Arzamasov, S.N. Yablokov, D.A. Rodionov Institute for Information Transmission Problems, RAS, Moscow, Russian Federation 16:30 – 16:50 Molecular pathology of carotid body tumors A. Snezhkina1, E. Lukyanova1, D. Kalinin2, A. Golovyuk1, E. Pudova1, M. Fedorova1, S. G. Krasnov1, N. A. Kudryavtseva1,3 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia; 3National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia 16:50 – 17:10 Coffee break

17:10 – 17:40 New method for estimation of number of transcription factor binding sites using results of processing of ChIP-seq data by different peak callers S. Kolmykov1, 2, Yu. Kondrakhin1,3, Fedor Kolpakov1,3 1 Biosoft.Ru Ltd., Novosibirsk, Russia 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 3 Institute of Computational Technologies SB RAS, Novosibirsk, Russia 17:40 – 18:00 Zebrafish early neural crest differentiation to pigment cells of different types Shubhankulova T, Makeev Vsevolod, Kelsh R. VIGG RAS, MIPT, Moscow, Russia

SECTION: «Bioinformatics and systems biology of plants» 22 August, Wednesday

Chairs: Elena Salina, Institute of Cytology and Genetics of SB RAS Alexey Kochetov, Institute of Cytology and Genetics of SB RAS.

09:00-09:35 Genome wide analysis of quantitative disease resistance against Verticillium wilt in the model legume Medicago truncatula M. Mazurier1, M. Toueni1, A. Sbeiti1, M.C. Tardin2, M.C. Gras2, M. Rickauer1, L. Gentzbittel, Cécile Ben1* 1 EcoLab, Université de Toulouse, CNRS, Toulouse INP, UPS, Toulouse, France; 2 R2n – Centre de Recherche Le Bourg, 12510 Druelle, France 09:35-10:00 GENOME-WIDE ASSOCIATION STUDY BETWEEN CHICKPEA ACCESSIONS FROM VIR COLLECTION AND PHENOTYPIC DATA A.B. Sokolkova1,*, M.A. Vishnyakova2, S. Bulyntsev2, P.L. Chang3,4, N. Carrasquilla- Garcia4, M.G. Samsonova1, S.V. Nuzhdin1,3 1Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia; 2Federal Research Centre All- Russian N.I. Vavilov Institute of Plant Genetic Resources (VIR), St. Petersburg, Russia; 3University of Southern California, Los Angeles, CA, USA 4Department of Plant Pathology, University of California, Davis, CA, USA 10:00-10:25 Global gene expression in organ-specific cold stress response in Arabidopsis thaliana A. Klepikova1,2,*, I. Kulakovsky3,4, A. Kasianov2,3, M. Logacheva2,5,6, A. Penin1,2,5 1Institute for Information Transmission Problems RAS, Moscow, Russia 2Lomonosov Moscow State University, Moscow, Russia 3N.I. Vavilov Institute of General Genetics RAS, Moscow, Russia 4Engelhardt Institute of Molecular Biology RAS, Moscow, Russia 5Kazan Federal University, Kazan, Russia 6Skolkovo Institute of Science and Technology, Skolkovo, Russia 10:25-10:50 Regulation of metabolic pathway underlying anthocyanin pigmentation of barley pericarp Olesya Shoeva1, T. Kukoeva1, E. Gordeeva1, A. Glagoleva1, E. Khlestkina1,2,3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 N.I. Vavilov All-Russian Research Institute of Plant Genetic Resources (VIR), Saint-Petersburg, Russia 10:50-11:10 Coffee-break 11:10-11:35 Detection of genes involved in regulation of wheat flowering time Antonina A. Kiseleva1, Shcherban A.B. 1, Leonova I.N. 1, Salina E.A. 1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 11:35-12:00 Genetic Mechanisms of Resistance to Golden Potato Cyst Nematode Globodera rostochiensis in Solanum phureja Anastasiya A.Egorova1, 2, N.A. Shmakov1, S.V. Gerasimova1, G.V. Vasilyev1, N.V. Shatskaya1, K.V. Strygina1, D.A. Afonnikov1, A.V. Kochetov1, 2 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk StateUniversity, Novosibirsk, Russia 12:00-12:25 Altering Barley Agronomic Traits via Targeted Mutagenesis Sophia V. Gerasimova1, A.M. Korotkova1, C. Hertig2, I. Otto2, S. Hiekel2, J. Kumlehn2, A.V. Kochetov1,3, E.K. Khlestkina1,3,4 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany; 3Novosibirsk State University, Novosibirsk, Russia; 4N.I. Vavilov All-Russian Research Institute of Plant Genetic Resources (VIR), Saint-Petersburg, Russia 12:25-12:50 Algorithms for prediction and analysis of regulatory regions in plants Tatiana Tatarinova, V. Solovyev, N. Alexandrov, A. Baranova, A. Kel1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Immunology and Physiology UB RAS, , Russia; 3 Novosibirsk State University, Novosibirsk, Russia 12:50-15:00 Poster session and lunch 15:00-15:35 Roles of non-coding RNAs in stress response in plants M. Chen1, J. Wang1, O.B. Dobrovolskaya2,3, V.N. Babenko2,3, Y.L. Orlov2,3, Samarina L.S.4* 1 Zhejiang University, , China; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 4 FSBSI Russian Research Institute of Floriculture and Subtropical Crops, Sochi, Russia 15:35-16:00 Dissecting the Mechanisms of EIN3-Dependent Regulation of Ethylene Response in Arabidopsis thaliana Elena V. Zemlyanskaya1,2*\, D.Y. Oshchepkov1, V.V. Mironova1,2, V.G. Levitsky1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 16:00-16:25 Sequencing and assembly of transcriptome in non-photosynthetic plant Lathraea squamaria and its dynamics during the light and dark period of the day Mariya D. Logacheva1,2, A.V. Klepikova3, M.I. Schelkunov3, A.S. Kasianov4, E.S. Gerasimov1,3, A.A. Penin1,3 1 – Lomonosov Moscow state university, Moscow, Russia; 2 – Skolkovo institute of science and technology, Moscow, Russia; 3 – Institute for information transmission problems, Moscow, Russia; 4 – Vavilov institute of general genetics, Moscow, Russia 16:25-16:50 Investigating genetic control of pigmentation in mutant barley lines with RNA-seq Nikolay Shmakov1, A.Glagoleva1, 2, A.Doroshkov1, G.Vasiliev1, N.Shatskaya1, O.Shoeva1 D.Afonnikov1,2, E.Khlestkina1 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia 16:50-17:10 Coffee-break 17:10-17:35 Assembly and annotation of genomes of some species from the apomictic genus Boechera and evolutionary analysis of apomixis-associated genes Vladimir Brukhin1,2, S. Kliver1, M. Rayko1, A. Komissarov1, E. Bakin1, C. Rushworth3, T. Mitchell-Olds4, U. Grossniklaus5 1 Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 41 Sredniy Prospekt, Vasilievsky Island, St. Petersburg; 2 Department of Plant Embryology & Reproductive Biology, Komarov Botanical Institute Russian Academy of Sciences, St. Petersburg, Russia; 3 University and Jepson Herbaria, University of California, Berkeley, USA; 4 Department of Biology, Duke University, Durham, USA; 5 Department of Plant & Microbial Biology Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland 17:35-18:00 De nova genome sequence of Karnal bunt pathogen (Telitia indica) of wheat Soma Marla 3 ,A.l Kumar 1, V. Pandey1, M. Singh1, M.S. Saharan 2, P. Mishra, R. Maurya. 1G.B.Pant University of Agriculture & Technology, Pantnagar, India, 2IARI, New Delhi, 3ICAR.NBPGR., New Delhi, India. Email 18:00-18:25 Sequencing and Assembly of Mitochondrial Genomes in Three Conifer Species Larix sibirica, Pinus sibirica and Pinus sylvestris Evgeniya Bondar1, A. Kirichenko1, V. Sharov1, Yu. Putintceva1, N. Oreshkova1, 2, S. Feranchuk3, 4, Yu. Konstantinov5, V. Shmakov5, V. Belkov5, D. Kuzmin1, S. Sadovsky1, K. Krutovsky1, 6, 7, 8 1 Siberian Federal University, Krasnoyarsk, Russia; 2 V.N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3 National Research Technical University, Irkutsk, Russia; 4 Limnological Institute, SB RAS, Irkutsk, Russia; 5 Siberian Institute of Plant Physiology and Biochemistry SB RAS; 6 George-August University of Göttingen, Göttingen, Germany; 7 Vavilov Institute of General Genetics RAS, Moscow, Russia; 8 Texas A&M University, College Station, USA 18:25-18:50 Discordant evolution of cellular genomes in peas (Pisum L.) as evidenced from complete sequences of plastid genomes and par-tial sequences of mitochondrial genomes V.S. Bogdanova1, A.V. Mglinets1, N.V. Shatskaya1, Oleg E. Kosterin1,2, V.I. Solovyev1,2, G.V. Vasiliev1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia

SECTION «Proteomics» 23 August, Thursday

Chairs: - Evgeny Nikolaev, Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia - Sergey Peltek, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; - Vadim Govorun, Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russia

Oral reports:

9:00 - 9:35 A number of blood biochemical parameters and endothelium-associated urine proteins of healthy people at head down bed rest, Pastushkova Lyudmila.Kh. 1, Kashirina D.N.1, Brzhozovsky A.G.1, Nosovsky A.M.1, Kononikhin A.S.1,2, Ivanisenko V.A.3, Tiys E.S.3, Nikolaev E.N.2, Larina I.M.1 1 Institute for Biomedical Problems - Russian Federation State Scientic Research Center, RAS, Moscow, Russia; 2Institute of Energetic Problems of Chemical Physics RAS, Moscow, Russia; 3Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 9:35 - 10:00 Development of Quantitative MRM Assays for the Measurement of 3,000 Proteins across 20 Mouse Tissues, S.A. Michaud1, A.L. Palmer1, N.J.T. Sinclair1, H. Pětrošová1, I. Feldmann2, Y. Mohammed1,3, A. Sickmann2, Christoph H. Borchers1,4-6 1 University of Victoria - Genome British Columbia Proteomics Centre, Victoria, Canada; 2 Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V., Dortmund, Germany North Rhine-Westphalia; 3 Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands South Holland; 4 University of Victoria, Department of Biochemistry and Microbiology, Petch , Canada; 5 Gerald Bronfman Department of Oncology, Jewish General Hospital, McGill University, Canada; 6 Jewish General Hospital Proteomics Laboratory, McGill University, Lady Davis Institute, Canada 10:00 - 10:25 Integrated experimental and computational pipeline for proteome-wide in tissue crosslinking analysis, K. A. T. Makepeace1, Y. Mohammed1,2, E.L. Rudashevskaya3, R.D. Brown1, Evgeny V. Petrotchenko1, A. Sickmann3, C. H. Borchers1,4 1University of Victoria – Genome British Columbia Protein Centre, University of Victoria, Vancouver Island Technology Park, Victoria, Canada; 2Center for Proteomics and Metabolomics, Leiden University, Leiden, Netherlands;3 Leibniz Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany; 4Dept of Biochemistry and Microbiology, University of Victoria, Canada 10:25 - 10:50 Dynamics of S.cerevisiae proteomic and transcriptomic response to changes in aeration conditions

Alexey Rozanov1, I. Mescheryakova1, S. Bannikova1, D. Oschepkov1, G. Vasiliev1, S. Peltek1 1Federal Research Center "Institute of Cytology and Genetics of the Siberian Branch of the RAS", Novosibirsk, Russia 10:50 - 11:10 Coffee Break

11:10 - 11:30 Human blood proteins after long duration space flights Darya N. Kashirina1, A.J. Percy2, L.Kh. Pastushkova1, C.H. Borchers2, E.N. Nikolaev3, I.M. Larina1 1Institute for Biomedical Problems – Russian Federation State Scientific Research Center RAS, Moscow, Russia; 2Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, Canada; 3Skolkovo Institute of Science and Technology, Skoltech, Moscow region, Russia. 11:30 - 11:50 Residue-residue contacts in modeling protein structure Malgorzata Kotulska1, P. P. Wozniak1, B. Konopka1, M. Kurczynska1, G. Vriend2, A. Sokolowska1, J. Wojciechowski1 1Wroclaw University of Science and Technology, Faculty of Fundamental Problems of Technology, Department of Biomedical Engineering, Wroclaw, Poland; 2Radboud University Medical Centre, Centre for Molecular and Biomolecular Informatics, Nijmegen, The Netherlands 11:50 - 12:10 Top-Down Venomics: A De Novo Sequencing Approach Kira Vyatkina1-4, D. Petras5 1 Saint Petersburg State University, Saint Petersburg, Russia; 2 Saint Petersburg Academic University of the Russian Academy of Sciences, Saint Petersburg, Russia; 3 ITMO University, Saint Petersburg, Russia; 4 Saint Petersburg State Electrotechnical University “LETI”, Saint Petersburg, Russia; 5 University of California, San Diego, CA, USA 12:10 - 12:35 Investigation of proteome of Baikal endemic amphipod Eu-limnogammarus cyaneus (Dybowsky, 1874) using LC-MS Daria Bedulina1*, Stefan Kalkhof2, Anton Gurkov1, Polina Drozdova1, Maxim Timofeyev1, Till Luckenbach3 1Irkutsk State University, Irkutsk, Russia; 2The University of Applied Sciences, Coburg, Germany; 3Helmholtz Centre for Environmental Research, Leipzig, Germany

12:50 - 15:00 Poster session and lunch 15:00 - 15:35 Nonthermal impact of terahertz (THz) radiation on living systems Peltek Sergey E. 1, Meshcheryakova I. A. 1, Goryachkovskaya T. N. 1, Rozanov, A. S. 1, Demidova E. V. 1, Starostin K.V. 1, Bryanskaya A.V. 1, Sergeeva S.V. 1, Loshenova P.S., Oshchepkov D. Y. 1, Demidov E. A. 1, G.L. Dianov1, 3 3 2 2 2 M.A.Logarkova , S.L. Kiselev , Timofeeva M. ,Vinokurov N.A. , Popik V.M. , M.A. Scheglov2 1 The Institute of Cytology and Genetics The Siberian Branch of the Russian Academy of Sciences; 2 Budker Institute of Nuclear Physics the Siberian Branch of the Russian Academy of Sciences, 3 Vavilov Institute of General Genetics RAS, Moscow, Russia

15:35 - 16:00 SRM-based Approach for β-lactamases Profiling Ekaterina Ilgisonis1, M. Rubtsova2, G. Presnova2 1Institute of Biomedical Chemistry; 2Lomonosov Moscow State University 16:00 - 16:25 The good, the bad, the aberrant: the role of prevailing splice-forms in proteomic studies Ekaterina Poverennaya1, O. Kiseleva1, M. Pyatnitskiy1, E.Ilgisonis1, E. Ponomarenko1, A. Lisitsa1 1 Institute of Biomedical Chemistry, Moscow, Russia 16:25 - 16:50 The search of blood-based biomarkers for schizophrenia by proteomics methods Elena Dmitrieva1, L. Smirnova1, A. Seregin1, A. Letova3, E. Kornetova1, A. Semke1, V. Zgoda 2 and S. Ivanova1 1 Mental Health Research Institute, Tomsk, Russia; 2 Institute of Biomedical Chemistry, Moscow, Russia; 3 Siberian State Medical University, Tomsk, Russia 16:50 - 17:10 Coffee Break

17:10 - 17:35 The Size of the Human Proteome: How Many Protein Species are Detectable Today? Elena Ponomarenko1, A. Kopylov1, V. Zgoda1, E. Poverennaya1, E. Ilgisonis1, A. Lisitsa1, S. Naryzhny1, E. Petrenko1, S. Radko1, A. Archakov1 1 Institute of Biomedical Chemistry, Moscow, Russia 17:35 - 18:00 Synergy of shotgun-MS and 2DE for analysis of proteome heterogeneity Olga Kiseleva1, E. Poverennaya1, S. Naryzhny1, V. Zgoda1, A. Lisitsa1 1 Institute of Biomedical Chemistry, Moscow, Russia 18:00 - 18:25 Cytotoxic proteins of human placenta Stanislav Skripkin1, E. Burkova2, G. Nevinsky1, 2 1 Novosibirsk State University, Novosibirsk, Russia 2 Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia 18:25 - 18:50 The analysis of blood proteins by ESI-mass spectrometry for en-dogenous mental disorders Alexandr A. Seregin1, L. P. Smirnova1, E. M. Dmitrieva1, A. A. Letova2, L. V. Loginova1, G. G. Simutkin1, S. A. Ivanova1 and V. Zgoda 3 1. Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia; 2. Siberian State Medical University, Tomsk, Russia; 3Institute of Biomedical Chemistry (IBMC)

SECTION « Animal genetics » 23-24 August

23 August, Thursday Chair: Mikhail Moshkin, ICG SB RAS, Novosibirsk, Russia 09:10-09:30 Genotyping of Nine Native Russian Cattle Breeds Combined with the 1000 Bull Genome Project Data Reveals Signatures of Selection and Adaptation in Russian Cattle Genomes A.A. Yurchenko1, N.S. Yudin1,2, Denis M. Larkin1,3 1 The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Royal Veterinary College, University of London, London, UK 09:30-10:00 Sequencing of Reindeer (Rangifer tarandus) Genomes: Insights into Evolution, Domestication and Adaptation M. W. Betsha1, 2, K. Pokharel1, M. Yao3, M. Honkatukia1, N. Mazzullo4, J. Peippo1, T. Reilas1, P. Soppela4, A. Stammler-Grossman4, F. Stammler4, K. H. Røed5 and Juha Kantanen1* 1Natural Resources Institute Finland, Jokioinen, Finland; 2Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland 3BGI-Tech, Guangdong, China; 4Arctic Center, University of Lapland, Rovaniemi, Finland; 5Norwegian University of Life Sciences, Oslo, Norway 10:00-10:20 Genome-wide Association Study for Body Temperature Maintenance Under the Cold Stress in Siberian Cattle A.V. Igoshin1, N.M. Belonogova1, A.A. Yurchenko1, N.S. Yudin1,2, D.V. Petrovsky1, D.M. Larkin1,3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Royal Veterinary College, University of London, London NW1 0TU, UK 10:20-10:45 Do rodent species adopt to underground lifestyle by different ways? Olga Bondareva1, A. Kasianov2 and N. Abramson1 1 Zoological Institute RAS, Saint Petersburg, Russia; 2 Vavilov institute of general genetics, Moscow, Russia 10:45-11:05 Coffee break 11:05-11:30 Effect of early experience on neuronal and behavioral re-sponses to con- and heterospecific odors in three closely related Mus taxa: Epigenetic contribution in formation of precopula-tory isolation. Elena Kotenkova1, A. Maltsev1, A. Ambaryan1, A. Romachenko2 1Severtsov Institute of Ecology and Evolution RAS, Moscow, Russia ; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 11:30-11:55 Inheritance of the Acoustic Signal Characters in Interspecific Hybrids of Bank (Clethrionomys glareolus) and Tianshan (C. centralis) Voles Marina Rutovskaya A.N. Severtsov Institute of Ecology and Evolution RAS, Moscow, Russia 11:55-12:35 Host Drosophila fitness and hormonal status depends on the genotype of Wolbachia symbiont Nataliya Е. Gruntenko, N.V. Adonyeva, Y.Y. Ilinsky, E.V. Burdina, O.V. Andreenkova, R.A. Bykov, I.Yu. Rauschenbach Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 12:35-12:55 Synapsis and recombination in intra- and interspecies hybrids between two voles species Microtus (Alexandromys) evoronensis и M. maximowizcii Tatyana Bikchurina1, 2, T. Vasil’eva3, M. Pavlenko3, I. Sheremet’eva3, I. Kartavtseva3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Federal Scientific Center of the East Asia Terrestrial Biodiversity FEB RAS, Vladivostok, Russia 12:55-13:15 LARKS, OWLS, SWIFTS AND WOODCOCKS AMONG THE FRUIT FLIES: HERITABLE INDIVIDUAL DIFFERENCES IN THE SLEEP-WAKE PATTERN INDUCED BY LONG AND, SOMETIMES, HOT SIBERIAN SUMMER DAYS Ludmila Zakharenko1, D.V. Petrovsky1, A.A. Putilov2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Molecular Biology and Biophysics, Novosibirsk, Russia 2. Domestication and Behavioral Selection 15:00-15:30 High-Density Genotyping of 15 Native Russian Sheep Breeds Reveals Genomic Regions Under Selection Related to Domestication, Acclimation and Economically Important Traits A.A. Yurchenko1, T.E. Deniskova2, A.V. Dotsev2, N.S. Yudin1,3, H. Reyer4, K. Wimmers4, G. Brem2,5, N.A. Zinovieva2, Denis M. Larkin1,6 1 The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; 2 L.K. Ernst Federal Science Center for Animal Husbandry, Podolsk, Moscow region, Russia ; 3 Novosibirsk State University, Novosibirsk, Russia; 4 Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany; 5 Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria; 6 Royal Veterinary College, University of London, London, UK

15:30-15:50 Hippocampal differentially expressed genes between tame and aggressive foxes are included in pathways associated with stress, behavior and adult neurogenesis Yury Herbeck, M. Genaev, G. Vasiliev, R. Gulevich, S. Shikhevich, D. Shepeleva, D. Afonnikov, L. Trut Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 15:50-16:10 Gene Expression Related to Aggressive Behavior on Rat Model Irina V. Chadaeva1,2, A.O. Bragin1, R.V. Kozhemyakina1, KlimovaN.V.1, Y.L. Orlov 1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 3. Onthogenesis and Epigenetics 16:10-16.40 Genotype of recipient mother modulate body composition and immunocompetence of transferred progenies Ludmila Gerlinskaya1, E. Litvinova1 , G. Kontsevaya1 , N. Feofanova1, 2, K. Achasova1 , M. Anisimova1 , S. Maslennikova1 , M. Zolotykh1 , M. Moshkin1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 2 Institute of Immunology 16:40-17.00 Germ Cell Migration under GAGA-factor Control Asya Khruscheva1,2, K. Ahmetova1, S. Fedorova1,2, E. Baricheva1, N. Dorogova1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk National Research State University, Novosibirsk, 630090 Russia 24 August, Friday 4. Models of Human Pathology and Test Objects 09:00-09:45 Exploring neuroprotective potential of astrocytes Sergey Kasparov University of Bristol, United Kingdom 09:45-10:05 IGNG1-IGNG3 locus and its possible role in the multiple scle-rosis Marina Fridman1, P. Bycadorov1, N.Oparina2, V.Makeev1 1 Vavilov Institute of General Genetics, RAS, Moscow, Russia; 2 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden 10:05-10:25 Genetic control of the stress-sensitivity in hypertensive ISIAH rats Olga Redina1, S. Smolenskaya1, L. Fedoseeva1, A. Markel1,2 1Institute of Cytology and Genetics SB RAS, Novosibirsk,Russia; 2Novosibirsk State University, Novosibirsk, Russia 10:25-10:45 Selected rat strains HT, LT as a model for the study of dysadaptation states dependent on the level of excitability of the nervous system Natalya Dyuzhikova, A.I. Vaido Pavlov Institute of Physiology of the RAS, St. Petersburg, Russia 10:45-11:10 Coffee break 11:10-11:30 Features of the autophagy process during its induction by 48-h fasting and inhibition by chloroquine in the rat liver Oyuna S. Kozhevnikova, D.V. Telegina, E.A. Zolotenkova, M.A. Tyumentsev, N.G. Kolosova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 11:30-11:50 The Hormonal Mechanism Of Heat Stress Effect On The Carbohydrate Metabolism In Drosophila Melanogaster Females Margarita A. Eremina1, E.K. Karpova1, N.E. Gruntenko1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 11:50-12:10 Drosophila Mutational models for Huntington’s Disease, Parkinson’s Disease with Dementia and Leavy Bodies and Genomic disorder Williams-Beuren Syndrome Elena V. Savvateeva-Popova Pavlov Institute of Physiology of the RAS, St. Petersburg, Russia

SECTION «Organization of education process for research in the field of bioinformatics and systems biology» 23 August

Chairs  Mikhail Fedoruk, Rector of Novosibirsk State University, Novosibirsk, Russia  Nikolay Kolchanov, Scientific Advisor of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia  Ivo Grosse, Institute of Computer Science, Martin Luther University Halle-Wittenberg, Halle, Germany

Moderators  Dmitry Afonnikov  Alexey Okunev  Sergey Lashin  Yuriy Orlov

1) Teaching Medicine and Biology through Systems Biology H.V.Westerhoff

2) Sergey Lashin, Making Science and Scientists in Information Biology: Half of a Century in Novosibirsk

3) Dmitry Afonnikov, Mixing Down Biologists and Computer Scientists: Novel Inderdisciplinary Program «Information Technologies, Bioinformatics and Agrotechnologies” at NSU

4) Ivo Grosse, to be announced

5) Olga Krebs, to be announced

6) Creation of a Russian intellectual portal for highly structured human omix data based on database technology and knowledge. Anatoly Shlikht

7) Using the UCSC Genome Browser as a tool that empowers non-programmer biologists to perform genome-scale bioinformatics; Leonard Lipovich;

8) The experience of training specialists in bioinformatics in A. Ivashchenko*, R. Niyazova, Sh. Atambayeva, A. Pyrkova

9) Chemogenomics as an essential academic discipline in the structure of modern biotechnological education A.V.Timofeev

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21, 22 and 23 of August

13.30-14.30 Practical training "Optimization of program code», INTEL, Gold Sponsor

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SYMPOSIUMS

SYMPOSIUM «Systems Biology and Biomedicine» SBioMed-2018 21-22 August 2018

21 August, Tuesday 09.00-09.10 Opening remarks N.A. Kolchanov (Novosibirsk, Russia) A.V. Kochetov (Novosibirsk, Russia) A.Ju. Letyagin (Novosibirsk, Russia) 09.10-10.50 Medicine in the “Omics” Era Chairs: L. Lipovich (Detroit, USA) Ju.L. Orlov (Novosibirsk, Russia) S.E. Peltek (Novosibirsk, Russia) 09.10-09.40 Plenary lecture From Genome to Clinical Medicine: Non-coding Mechanisms for Novel Therapeutics Leonard Lipovich Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA 09.40-09.55 Omics-Based Approach to Profiling of Human Atherosclerotic Plaques Maria S. Nazarenko1,2,3, A.A. Sleptsov1, A.V. Markov1, A.N. Kazantsev2, O.L. Barbarash2, V.P. Puzyrev1,3 1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia; 2Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia;3Siberian State Medical University, Tomsk, Russia 09.55-10.10 Real-Time Lipidomic Analysis of Biological Tissue Samples Vasily Eliferov1, E. Zhvansky1,2, A. Sorokin1, V. Shurkhay1,3, I. Popov1,2, E. Nikolaev4 1Moscow Institute of Physics and Technology, Moscow, Russia; 2Institute for Energy Problems of Chemical Physics of RAS, Moscow, Russia; 3N. N. Burdenko Scientific Research Neurosurgery Institute, Moscow, Russia; 4 Skolkovo institute of science and technology, Moscow Region, Russian Federation 10.10-10.25 Large Genome-Wide Association Study Provides Insight into the Genetic Architecture of Low Back Pain and Its Risk Factors Yakov A. Tsepilov2,3, M.B. Freidin1^, M. Palmer4, L.C. Karssen6, P. Suri4,5, Y.S. Aulchenko3,6, F. MK Williams1 1Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK; 2Novosibirsk State University, Novosibirsk, Russia; 3Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; 4University of Washington, Seattle, USA; 5VA Puget Sound Health Care System, Seattle, USA; 6 PolyOmica, The Netherlands 10.25-10.40 Investigation of Meningioma Samples by Multi-omics Analysis Konstantin Bocharov1, 2, A. Sorokin1, V. Shurhkhay1, 3, I. Popov1, 2, 4, E. Zhvansky1, A. Potapov3, E. Nikolaev1, 2, 5 1Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia; 2 Institute of Energy Problems of Chemical Physics of RAS, Moscow, Russia; 3 N. N. Burdenko Scientific Research Neurosurgery Institute, Moscow, Russia; 4 Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia; 5 Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, Russia 10.40-10.50 Closing remarks

10.50-11.10 Coffee-break

11.10-13.00 Genotyping precision medicine Chairs: V.A. Stepanov (Tomsk, Russia) A.N. Tulpakov (Moscow, Russia)

11.10-11.40 Plenary Lecture Precision Medicine in Endocrinology Anatoly N. Tulpakov Endocrinilogy Research Center, Moscow, Russia 11.40-11.55 Verification of MODY Diabetes: Phenotypic and Molecular-Genetic Characteristics Alla K. Ovsyannikova1, O.D. Rymar1, E.V. Shakhtshneider1, M.I. Voevoda1 1Research Institute of Therapy and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences Russia 11.55-12.10 The Spectrum of Common and Rare CYP1B1 Gene Variants in Russia Patients with Congenital and Juvenile Open Angle Glaucoma Dinara Ivanoshchuk1,2, 3,, O. Fenkova 4, S.Mikhailova1, I. Bychkov5, N. Konovalova6, O. Konovalova6, M.Voevoda1,2,3, A.Fursova4, A. Romaschenko1,2 1Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Research Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia; 4Novosibirsk State Regional Clinical Hospital, Novosibirsk, Russia; 5The academician S.N. Fyodorov Federal State Institution «Intersectoral Reseach and Technology Complex «Eye Microsurgery» of Ministry of Health, Novosibirsk, Russia 12.10-12.25 Potential Genetic Markers of Alzheimer’s Disease, Which Play a Significant Role in Aging Anna Bocharova1, K. Vagaitseva1, O. Makeeva1,2, A. Marusin1, N. Zhukova3, I. Zhukova3, V. Alifirova3, M. Matveeva3, V. Stepanov1,4 1 Research Institute of Medical Genetics, Tomsk National Medical Research Center, Tomsk, Russia; 2Nebbiolo Center for Clinical Trials, Tomsk, Russia; 3 Siberian State Medical University, Tomsk, Russia; 4 Tomsk State University, Tomsk, Russia 12.25-12.40 New Regulatory SNPs Associated with Colorectal Cancer Elena Leberfarb1,2, A. Degtyareva1, 2 , V. Maximov 1,2, M. Voevoda1,3, A.Autenshlus2, D. Morozov4, A. Sokolov4, D. Veselova2, S. Bannikova1, E. Demidov1, L. Bryzgalov1, T. Merkulova 1,3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State Medical University, Novosibirsk, Russia ; 3 Novosibirsk State University, Novosibirsk, Russia; 4City Clinical Hospital No. 1, Novosibirsk, Russia 12.40-12.55 Polymorphic Variants in Stress Resistance Genes and Human Emotional Stability I. Mosse1, Kristina Bakunovich1, I. Charykova2, L. Kukhtsinskaya 1, P. Yeuleyeu1 1 Institute of Genetics and Cytology, NAS of Belarus, Minsk; 2 Republican Scientific and Practical Center of Sports, Minsk, Belarus 12.55-13.10 Human disease panels and sample preparation for NGS in clinical research from Roche Irina Karpova Roche Diagnostics Rus LLC, Moscow, Russia, Silver Sponsor 13.10-13.15 Closing remarks 13.15-14.00 Lunch

14.00-15.00 POSTER SESSION 1 Genetics and Molecular Biology Moderators: V.N. Maximov (Novosibirsk, Russia) Yu.L. Orlov (Novosibirsk, Russia) V.F. Prokofiev (Novosibirsk, Russia) 15.00-16.50 Molecular biology in human health and disease Chairs: T.I. Merculova (Fairfax, USA) A.G. Pokrovsky (Novosibirsk, Russia) M.Yu. Skoblov (Saint-Petersburg, Russia)

15.00-15.15 Promoter-Pathway Analysis Approach to Interpretation of Microarray Data of the antitumor peptide CIGB-552 Fernandez Massó JR1, P. Gardon D1, V. Blomquist D2, N. L2, Vallespí M1 1Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Cuba.; 2Department of System biology, Center for Genetic Engineering and Biotechnology, Cuba 15.15-15.30 Development and Optimization DNA Platform for Suppressing Cancer Cells Darya Nedorezova1, D.Kolpashchikov1, 2 1Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg, Russia; 2University of Central Florida, Orlando, Florida, USA 15.30-15.45 Defining the Genetic Control of Human Blood Plasma Glycome Using Genome- Wide Association Study Sodbo Sharapov1,2, Y. Tsepilov1,2, L. Klaric3,4, M. Mangino5, F. Vuckovic3, H. Csmpbell6,7, M. Dunlop7, S. Farrington7, K. Suhre8, T. Spector5, G. Lauc3, Y. Aulchenko1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia ; 2 Novosibirsk State University, Novosibirsk, Russia; 3Genos Glycoscience Research Laboratory, Zagreb, Croatia; 4Human Genetics Unit, MRC, Institute of Genetics and Molecular Medicine, University of Edinburgh; 5Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK; 6Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh EH8 9AG, UK; 7Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK; 8Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, PO 24144 , Qatar 15.45-16.00 Evolutionary Analysis and Mathematical Modeling of Gene Networks of Energy Metabolism Disorders Sergey A. Lashin1,2, Z.S. Mustafin1,2, V.A. Manevich2, D.A. Afonnikov1,2, E.V. Ignatieva1,2, Yu.G. Matushkin1,2, V.V. Klimontov2,3 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk StateUniversity, Novosibirsk, Russia; 3Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Novosibirsk, Russia, Novosibirsk, Russia 16.00-16.15 Reperfusion Activates AP-1 and Heat Shock Response in Donor Kidney Alexandr Reznik1,2, O. Plotnikova3, A. Skvortzov4, M. Skoblov3,5, O. Reznik4,6, A. Baranova2,3,5,7 1Center for Bioinformatics, First Pavlov State Medical University, Saint-Petersburg, Russian Federation; 2Department of Genetics, Atlas Biomed Group, Moscow, Russian Federation; 3Moscow Institute of Physics and Technology, Moscow, Russian Federation; 4Organ transplant department, First Pavlov State Medical University, Saint-Petersburg, Russian Federation; 5Research Centre for Medical Genetics, Moscow, Russian Federation; 6Organ Procurement Center, Research Institute of Emergency Medicine n.a. I.I. Dzhanelidze, Saint-Petersburg, Russian Federation; 7School of Systems Biology, George Mason University, Fairfax, VA, United States 16.15-16.30 DNA Methylation Level in Regulatory Regions of mtDNA and Three Mitochondria-Related Nuclear Genes in Atherosclerosis Mariya V. Golubenko1,2, A.V. Markov1, A.A. Zarubin1, A.A. Sleptcov1, A.N. Kazantsev2, O.A. Makeeva1, V.V. Markova1, I.A. Koroleva1, M.S. Nazarenko1,2, O.L. Barbarash2, V.P. Puzyrev1 1 Research Institute of Medical Genetics, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”, Tomsk, Russia; 2Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia 16.30-16.45 Enhancement of cytotoxic effects of temozolomide in glioblastoma cell lines by Tdp1 inhibitors Olga Oleshko1, S. Cheresiz1, K. Kovaleva1,2, O. Yarovaya1,2, N. Salakhutdinov1,2, A. Pokrovsky1 1 Novosibirsk State University, Novosibirsk, Russia; 2 N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, Novosibirsk, Russia 16.45-16.50 Closing remarks

16.50-17.10 Coffee-break

17.10-18.30 Translational Medicine: from Animal Models to Clinical Studies Chairs: M.P. Moshkin (Novosibirsk, Russia) N.P. Bgatova (Novosibirsk, Russia) 17.10-17.25 Development and Validation of Experimental Cholangiocarcinoma Models for Ex Vivo and In Vivo Analysis Galina A. Maksimova, A.V. Kovner, A.G. Shilov, M.Yu. Pakharukova, A.V. Mordvinov Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 17.25-17.40 Nanoparticles of Manganese Oxide Induce Stress Granule Formation in Human Glioblastoma Cells Nina B. Illarionova1, K.N. Morozova1, 2, Y.B. Dorofeeva3, D.V. Petrovski1, A.V. Romashenko1, E.L. Zavjalov1, E. Kiseleva1, Y.M. Moshkin1, M.P. Moshkin1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University; 3 National Research Tomsk State University 17.40-17.55 Empagliflozin and Linagliptin Ameliorate Podocyte Injury and Enhance Autophagy in a Model of Type 2 Diabetic Nephropathy Anton I. Korbut1, V.V. Klimontov1, Yu.S. Taskaeva1, N.P. Bgatova1, E.L. Zavyalov2 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 17.55-18.10 Lithium and Autophagy in Hepatocellular Carcinoma Iulia Taskaeva1, 2, N. Bgatova1 1 Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 18.10-18.25 FastPrep: Full Solution for Sample Homogenization and Extration of DNA, RNA and Proteins Sergey E. Sedykh1,2, S.I. Solomakha2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 MPBA Diagnostika, Moscow, Russia, Silver Sponsor

18.25-18.30 Closing remarks

Wednesday, 22 August 2018 09.00-10.50 Cell technology and regenerative medicine Chairs: V.I. Konenkov (Novosibirsk, Russia) O.V. Poveschenko (Novosibirsk, Russia) S.V. Sennikov (Novosibirsk, Russia) 09.00-09.30 Plenary lecture Epigenetic Codes and Their Implications in Stem Cell Biology: an Insight Derived From Deep Sequencing Analysis Xiaodong Zhao Hangzhou Lifereal Biotechnology Co., Ltd., China 09.30-09.45 Cellular Technologies Based on Dendritic Сells Sergey V. Sennikov1, V.V. Kurilin1, J.A. Lopatnikova1, J.A. Shevchenko1, E.V. Kulikova1, A.Z. Maksutov1,2, J.N. Khantakova1,V.P. Tereshchenko1, A.N. Silkov1, M.S. Kuznetsova1, A.A. Khristin3, N.A. Kiryishina4, V.V. Kozlov4, A.P. Cherkasov3, S.V. Sidorov5, A.V. Sokolov3, A.E. Vitsin3 1Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia; 2Federal Budgetary Scientific State Research Center of Virusology and Biotechnology "Vector", Koltsova, Russia; 3City Clinical Hospital no. 1, Novosibirsk, Russia; 4Novosibirsk Regional Clinical Oncology Center, Novosibirsk, Russia; 5 Department of Surgery, Novosibirsk State University, Novosibirsk, Russia 09.45-10.00 The Use of Mesenchymal Stem Cells and Erythropoietin in Lower Limb Ischemia Natalya Bondarenko, A. Lykov, M. Surovtseva, O. Poveschenko, A.Kabakov, I.Kim, O.Kazakov, A.Poveschenko

Institute of Clinical and Experimental Lymphology - branch of ITSiG SB RAS, Novosibirsk, Russia 10.00-10.15 Possible Mechanisms of Therapeutic Effects of Mesenchymal Stromal Cells Conditioned Medium on the Model of Cryptorchidism in Rats Natalia A. Basalova 1, G.D Sagaradze 1,2, E.S. Kuznetsova 1, V.I. Kirpatovsky 1,3, D.A. Ohobotov 1,2, A.A. Kamalov 1,2 , A.Yu. Efimenko 1,2 1Institute for Regenerative Medicine, Medical Research and Educational Centre, MSU, Moscow, Russia ; 2Department of Biochemistry and Molecular Medicine, Faculty of Medicine, MSU, Moscow, Russ; 3Research Institute of Urology named N.A. Lopatkin - branch FGBU "Federal medical research center named after P.A. Herzen", Moscow 10.15-10.30 Epigenetic Changes of MMSCs Under the Influence of Calcium Phosphate Coating with Different Roughness L. Litvinova1, Kristina Yurova1, V. Shupletsova1, O. Khaziakhmatova1, E. Melashchenko1, N. Todosenko1, V. Malashchenko1, E. Shunkin1, Y. Sharkeev2,3, E. Komarova3, M. Sedelnikova3, I. Khlusov1,2 1Basic Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad, Russia;; 2Tomsk Polytechnic University, Tomsk, Russia;; 3Laboratory of Physics of Nanostructured Biocompatible Composites, Institute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences, Tomsk, Russia 10.30-10.45 Erythropoietin Augment Therapeutic Potential of Mesenchymal Stem Cells in Rat with Degenerate Intervertebral Disk Alexander P. Lykov1,2, N.A. Bondarenko1,2, O.V. Poveshchenko1,2, I.I. Kim1,2, M. A. Surovtseva1,2, Z.B. Sadykova3, P.A. Semin3, E.L. Zavjalov4, A.L. Krivoshapkin3, V. I. Konenkov1 1Research Institute of Clinical and Experimental Lymрhology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation; 2Research Institute of Circulation Pathology, Ministry of Health Care of Russian Federation, Novosibirsk, Russian Federation; 3Novosibirsk government medical university, Novosibirsk, Russian Federation; 4Federal research center Institute of cytology and genetics of Siberian branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

10.45-10.50 Closing remarks

10.50-11.10 Coffee-break

11.10-13.00 New biomarkers and molecular targets Chairs: V.V. Klimontov (Novosibirsk, Russia) M.A. Korolev (Novosibirsk, Russia)

11.10-11.25 Association of Intracellular Proteolytic Systems and Locomotor Proteins in Tissues of Primary Tumor and Lymphogenous Metastases of Breast Cancer Еlena Shashova, N. Tarabanovskaya, E.Slonimskaya, I.Kondakova Tomsk National Research Medical Center of the Russian Academy of Sciences” (Tomsk NRMC), Russia 11.25-11.40 Serum Levels of WISP1/CCN4 in Subjects with Type 2 Diabetes: the Relationships with Body Fat Distribution and Adipose Tissue Dysfunction. Vadim V. Klimontov1, D.M. Bulumbaeva1, A.P. Lykov1, O.N. Fazullina1, N.P. Bgatova1, A.F.H.P. Pfeiffer2,3,4, O. Pivovarova2,3,4 , N. Rudovich2,3,4,5 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Novosibirsk, Russia; 2German Center for Diabetes Research (DZD), Muenchen-Neuherberg, Germany; 3German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; 4Charité University Medicine, Berlin, Germany; 5Spital Bülach, Bülach, Switzerland 11.40-11.55 Serum Markers in Head and Neck Squamous Cell Carcinoma Gelena V. Kakurina1, О.V. Cheremisina1, I.V. Kondakova1, Е.L. Choynzonov1,2 1Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia; 2Siberian State Medical University, Tomsk, Russian Federation 11.55-12.10 Phenotypes of Peripheral Dendritic Cells in Patients with Early Rheumatoid Arthritis Maxim Korolev1, V. Omelchenko1, E. Letjagina1, O. Poveshchenko1, A. Lykov 1, M. Surovtseva1, N. Banshсhikova1 1 Institute of Clinical and Experimental Lymphology - a branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 12.10-12.25 Natural Bispecific Antibodies – Biochemical Markers оf Autoimmune Pathology Sergey E. Sedykh, V.V. Printz, V.N. Buneva, G.A. Nevinsky Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk State University, Novosibirsk, Russia 12.25-12.40 Circulating DNA-Markers for Diagnostics and Monitoring of Lung Cancer: Analysis of LINE-1 Retrotransposons Methylation in the Blood Anastasiya Ponomaryova1,2, E. Rykova3,4, A. Bondar3, A. Dobrodeev1, A. Zavyalov1, S. Tuzikov1, V. Vlassov3, N. Cherdyntseva1,5, P. Laktionov3,6 1Tomsk National Research Medical Center RAS, Tomsk, Russia; 2Tomsk Polytechnical University, Tomsk, Russia; 3Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 4Novosibirsk State Technical University, Novosibirsk, Russia; 5Тomsk State University, Tomsk, Russia; 6Meshalkin Siberian Federal Biomedical Research Center, Novosibirsk, Russia 12.40-12.55 DNA Methylation and Expression of MicroRNA Genes in Unstable Carotid Atherosclerotic Plaques Anton Markov1, A. Zarubin1,2, M. Nazarenko1,2,3, A. Kucher1, I. Koroleva1, D. Sharysh2, A. Kazantsev3, O. Barbarash3, V. Puzyrev1,2 1Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics, Tomsk, Russia ; 2Siberian State Medical University, Tomsk, Russia;; 3Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia 12.55-13.10 New brands, new opportunities for Scientific Research Ilya Volkov Khimexpert, Moscow, Russia, Silver Sponsor 13.10-13.15 Closing remarks 13.15-14.00 Lunch

14.00-15.00 Poster Session 2 BIOMEDICINE, PHARMACOLOGY AND CLINICAL MEDICINE Moderators: A.P. Lykov (Novosibirsk, Russia) V.V. Nimaev (Novosibirsk, Russia) A.O. Solovjeva (Novosibirsk, Russia)

15.00-16.50 Computer and experimental pharmacology Chairs: A.A. Lagunin (Moscow, Russia) P.G. Madonov (Novosibirsk, Russia) 15.00-15.30 Plenary Lecture Computer Assessment of Interaction Between Chemical Compounds and Human Kinome Pavel Pogodin1, A. Lagunin1,2, D. Filimonov1, A. Rudik, V. Poroikov1 1Institute of Biomedical Chemistry, Moscow, Russia; 2 Pirogov Russian National Research Medical University, Moscow, Russia 15.30-15.45 Virtual Screening of MEK1 Inhibitors Among Natural Compounds Based on ChEMBL Data and (Q)SAR Models B.V. Shilov1, A.A. Ivashkin1, Alexey A. Lagunin1,2 1 Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia; 2Institute of Biomedical Chemistry (IBMC), Moscow, Russia 15.45-16.00 MetaTox - Web Application for Generation Metabolic Pathways and Toxicity Estimation Anastasiya Rudik1, A. Dmitriev1, V. Bezhentsev1, A. Lagunin1,2, D. Filimonov1, V. Poroikov1 1Institute of Biomedical Chemistry (IBMC), Moscow, Russia; 2Medico-biological Faculty, Pirogov Russian National Research Medical University, Moscow, Russia 16.00-16.15 Drug-drug interactions severity prediction based on xenobiotic structural formulas and PASS prediction algorithm A. Dmitriev1, D. Filimonov1, A. Lagunin1,2, A. Rudik1, D. Karasev1, K. Murtazalieva1, V. Poroikov1 1 Institute of Biomedical Chemistry, Moscow, Russia; 2 Pirogov Russian National Research Medical University, Moscow, Russia 16.15-16.30 NMR and DFT Study of the Mechanism for Increased Antitumor Activity of Carboplatin in Mixture with Cucurbit[7]uril Irina Mirzaeva1, 2 , E. Pashkina3, 4, I. Andrienko1, E. Kovalenko1, N. Knauer3, A. Ermakov4, A. Aktanova4, V. Kozlov3 1 Nikolaev Institude of Inorganic Chemistry SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia; 4 Novosibirsk State Medical University, Novosibirsk, Russia 16.30-16.45 Investigation of Biological Effects of Cluster Complexes of Metals and Their Conjugates with Cyclodextrins in vivo and in vitro Tatyana Pozmogova1,2, A. Sovovieva1, Y. Vorotnikov3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Inorganic Chemistry, Novosibirsk, Russia

16.45-16.50 Closing remarks

16.50-17.10 Coffee-break

17.10-18.45 Digital medicine: present and future Chairs: A.Ju. Letyagin (Novosibirsk, Russia) D.A. Afonnikov (Novosibirsk, Russia) 17.10-17.40 Plenary Lecture Big Data and Modeling in Clinical Diagnostics Andrey Yu. Letyagin Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 17.40-17.55 The Advantage of the Multidimensional Data Visualization for the Characterizing of the Immune System State Marina Stakheyeva 1, 3, D. Eidenzon 2, M. Patysheva 1, N. Cherdyntseva 1, 3 1Cancer Research Institute of Tomsk National Research Medical Center of RAS, Tomsk, Russia; 2Novospark Corporation, Vaterloo, Canada ; 3Tomsk State University, Tomsk, Russia 17.55-18.10 Software "DoctorCT" for Modeling Images of Internal Organs, Based on Computer and Magnetic Resonance Imaging Artem Mishvelov1,2, K.Nuzhnya1, M. Kukharuk1 1 North-Caucasian Federal University, Stavropol, Russia; 2 Stavropol State Medical University, Stavropol, Russia 18.10-18.25 Studying Calcium Signaling in Individual Suspended Platelets Alexander Е. Moskalensky1,2, D.V. Spiryova1, O.Yu. Karmatskih1, A.Yu. Vorob’ev1,3 1 Novosibirsk State University, Novosibirsk, Russia; 2 Voevodsky Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; 3 N.N. Voroztsov Institute of Organic Chemistry, Novosibirsk, Russia 18.25-18.40 Up-to-date Digital Infrared Thermography in Biomedicine Boris G. Vainer1, 2 1 Rzhanov Institute of Semiconductor Physics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 18.40-18.45 Closing remarks

18.45-19.00 Closing ceremony and awarding A.Ju. Letyagin (Novosibirsk, Russia) V.V. Klimontov (Novosibirsk, Russia)

SYMPOSIUM «Systems biology of DNA repair processes and programmed cell death» SbPCD-2018 20-22 August 2018

21 August 10:50-11:10 Coffee Break

11:10-11:55 Cross-talk between apoptosis and autophagy: the role of suppressed translation Boris Zhivotovsky Lomonosov Moscow State University, Russia; Karolinska Institutet, Stockholm, Sweden 11:55-12:20 Role of miR-126a in regulation of expression of anti-apoptotic protein BCL2 Lyudmila Gulyaeva Federal Research Centre “Fundamental and Translational Medicine”, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia 12:20-12:45 Novel therapeutic approaches based on Lactaptin action Olga Koval1, 2, O. Volkova3, G. Kochneva4, S. Kulemzin3, A. Gorchakov1, A. Tkachenko1, A. Nushtaeva1, O. Troitskaya1, E. Kuligina1, A. Taranin3, V. Richter1 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 4 State Research Center of Virology and Biotechnology “Vector” Rospotrebnadzor, Koltsovo, Russia 12:45-13:05 Autophagy modulation by antitumor protein lactaptin Аnastasiya Tkachenko1, O. Troytskaya1, A. Yunusova1, V. Richter1, O. Koval1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 13:05-13:30 Comparative analysis of lactaptin produced in bacterial and eukaryotic cells. Purification and activity

Olga Chinak1*, O. Volkova2, T. Belovezhec2, A. Gorchakov2, A. Tkachenko1, E. Kuligina1, V. Ricter1, O. Koval1,3 1 Institute of Chemical Biology and Fundamental Medicine, SB, RAS, Novosibirsk, Russia; 2Institute of Molecular and CellularBiology SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia

13:30-14:30 Lunch

Part 2. Systems biology of pharmacological targeting of apoptosis Chairpersons: Inna Lavrik, Vladimir Ivanisenko

14:30-15:00 Towards understanding of apoptosis regulation using computational biology Inna N. Lavrik Department of Translational Inflammation Research, Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany; Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 15:00-15:30 Rational Design of Small-Molecule Compounds Targeting CD95 Programmed Cell Death Pathway

Nikita Ivanisenko1,3, V. Ivanisenko1, I. Lavrik1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany; 3 Novosibirsk State University, Novosibirsk, Russia

15:30-16:00 Growth of interest to research in the field of medical genetics according to the analysis of scientific publications Vladimir A. Ivanisenko1, O.V. Saik1, T.V. Ivanisenko1, Choynzonov E.L.2, I.N. Lavrik1, 3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia; 3 Otto von Guericke University Magdeburg, Magdeburg, Germany 16:00-16:20 Analysis of programmed cell death in associative gene net-work of glaucoma reconstructed using AND system Olga V. Saik1, P.S. Demenkov1, O.S. Konovalova2, N.A. Konovalova3, I.N. Lavrik1, 4, V.A. Ivanisenko1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, the Ekaterinburg branch of MNTK Eye Microsurgery, Tyumen, Russia; 3 Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, Tyumen, Russia; 4 Otto von Guericke University Magdeburg, Magdeburg, Germany 16:20-16:40 Topological properties of graph of hydrogen bonds forming in SOD1 protein indicate critical regions in its structure Nikolay Alemasov, V. Ivanisenko Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

16:50-17:10 Coffee Break // Poster Session

Wednesday August 2 2018

Part 3. DNA Repair Chairpersons: Olga Lavrik, Dmitry Zharkov

10:50-11:10 Coffee Break

11:10-11:40 Non canonical roles of BER enzymes in RNA processing: novel perspectives in cancer biology through the study of APE1 RNA- and protein-interactomes Gianluca Tell Dept. of Medicine, University of Udine, Udine, Italy 11:40-12:10 Poly(ADP-ribose) polymerase 1 in regulation of DNA repair and longevity Olga I. Lavrik Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia 12:10-12:40 Mechanisms of poly(ADP-ribosyl)ation and its role in genotoxic stress response Aswin Mangerich Molecular Toxicology Group, University of Konstanz, Germany 12:40-13:10 Poly- and mono(ADP-ribosyl)ation of DNA strand breaks by PARP2 and PARP3 enzymes G. Zarkovic1, E.A. Belousova2, I. Talhaoui1, C. Saint-Pierre3, M.M. Kutuzov2, B.T. Matkarimov4, D. Gasparutto3, O.I. Lavrik2, Alexander A. Ishchenko1 1 Groupe «Réparation de l’ADN», Equipe Labellisée par la Ligue Nationale Contre le Cancer, CNRS UMR8200, Univ. -Sud, Université Paris-Saclay, Villejuif, France; 2 Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia; 3 Université Grenoble Alpes, INAC/SPrAM UMR5819 CEA CNRS UGA, Grenoble, France; 4 National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan 13:10-13:30 DNA Is a new acceptor of PARP3 protein Ekaterina Belousova1, A. Ishchenko2, O. Lavrik1 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 UMR8200 – CNRS Paris Saclay, Gustave Roussy, 94805 Villejuif, France

13:30-14:30 Lunch

14:30-15:00 Targeted DNA damage and repair: the cell’s multitool for genome regulation Dmitry O. Zharkov Novosibirsk State University, Novosibirsk, Russia; Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia 15:00-15:20 Molecular model of DNA glycosylase stimulation by human apurinic/apyrimidinic endonuclease 1 O.A. Kladova1, D.A. Iakovlev1, A.A. Ishchenko2, M. Saparbaev2, O.S. Fedorova1, 3, Nikita A. Kuznetsov1, 3 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Groupe «Réparation de l’ADN», Equipe Labellisée par la Ligue Nationale contre le Cancer, CNRS UMR8200, Université Paris-Sud, Gustave Roussy Cancer Campus, Villejuif Cedex, France; 3 Novosibirsk State University, Novosibirsk, Russia 15:20-15:40 Biological activity of the new photoactive ruthenium nitrosyl complexes: cytotoxicity and effects on DNA repair D.V. Khantakova1, 2, D.V. Petrova1, 2, Inga Grin1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 15:40-16:00 The point mutations in the fingers domain increase the fidelity of DNA synthesis on undamaged DNA and abrogate DNA translesion synthesis in Y-family of DNA polymerases E.O. Boldinova, N.A. Miropolskaya, A.V. Ignatov, A.V. Kulbachinskiy, Alena Makarova Institute of Molecular Genetics RAS, Moscow, Russia

16:00-16:20 In vitro lesion bypass by human PrimPol Elizaveta Boldinova1, E.A. Belousova2, Anna V. Makarova1, 3, O.I. Lavrik2, Alena V. Makarova1 1 Institute of Molecular Genetics RAS, Moscow, Russia; 2 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 3 D. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

16:20-16:40 Translesion DNA synthesis by DNA polymerase iota and it's variants Evgemy Shilkin, A.V. Makarova Institute of Molecular Genetics RAS, Moscow, Russia 16:50-17:10 Coffee Break // Poster Session

17:10-17:30 TDP 1 inhibitors as potential antitumor drugs A. Zakharenko1, O. Luzina2, O. Salomatina2, O. Zakharova1, K. Volcho2, V. Kaledin3, V. Nikolin3, N. Popova3, N. Salakhutdinov2, O. Lavrik1 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Institute of Organic Chemistry SB RAS, Novosibirsk, Russia; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 17:30-17:50 Structural and biochemical insights on new atypical FPG/NEI DNA – glycosylases A.V. Yudkina1, 2, 3, D.O. Zharkov1, 2, M. Garcia-Diaz3 1 SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Stony Brook University, Stony Brook, US 17:50-18:10 Processivity of DNA repair enzymes E. Dyatlova1, D. Zharkov1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 18:10-18:30 Lesion recognition by bifunctional DNA-glycosylase Endo III and its catalytic mutants O.A. Kladova1, N.A. Kuznetsov1, 2, O.S. Fedorova1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia

Poster reports 1. DNA polymerases beta and lambda: gap-filling synthesis on the intact and damaged DNA templates in base excision repair, E.A. Maltseva, L.V. Starostenko, O.I. Lavrik, N.I. Rechkunova 2. Disaccharide nucleosides as inhibitors of DNA repairing enzymes, M. Drenichev, A. Komarova, N. Dyrkheeva, I. Kulikova, V. Oslovsky, O. Zakharova, A. Zakharenko, S. Mikhailov, O. Lavrik 3. PARPs and PARGs orchestrate the assembly/disassembly of FUS/Poly(ADP-ribose) compartments at DNA damage sites and FUS translocation to cytoplasmic stress granules, A. Singatulina, L. Hamon, M. Sukhanova, A. Bouhss, O. Lavrik, D. Pastré 4. Development of Tdp1 inhibitors based on natural biologically active compounds, A. A.Chepanova, A.L.Zakharenko, O.D.Zakharova, T.M.Khomenko, E.V.Suslov, N.S.Li-Zhulanov, K.P.Volcho, O.I. Lavrik 5. Activity of single nucleotide polymorphic variants of human AP-endonuclease 1, A. T. Davletgildeeva, I. V. Alekseeva, O. S. Fedorova, N. A. Kuznetsov 6. Modulatory effect of PAR on PARP1-YB-1 interactions, K. Naumenko, E. Alemasova, O. Lavrik 7. Comparative analysis of lactaptin produced in bacterial and eukaryotic cells. Purification and activity, O. Chinak, O. Volkova, T. Belovezhec, A. Gorchakov, A. Tkachenko, E. Kuligina, V. Ricter, O. Koval 8. Tyrosyl-DNA phosphodiesterase 1 (Tdp1) and its natural mu-tant SCAN1 inhibitors as prototypes of drugs, E. Mamontova, K. Kovaleva, A. Zakharenko, O.Yarovaya, J.Reynisson, O. Zakharova, E. Ilina, O. Lavrik 9. The influence of pH on damaged DNA processing by human apurinic/apyrimidinic endonuclease 1, I. V. Alekseeva, A. Bakman, Yu. N. Vorobjev, O. S. Fedorova, N. A. Kuznetsov

SYMPOSIUM Single-cell genomics: Neuroscience, Biodiversity and Evolution» BioGenEvo-2018 22-23 August 2018

22 August

9:00 - 9:35 Multiple Origins and Genomic Diversity of Cell Types in Animals: Sequencing 9:35 - 10:00 ofEvolution 2 million of single unicellular cells across eukaryotes phyla andto decipher possible the ways genealogy to multi of-cellularity neurons and I. Dovgal Kovalevskybrains Institute of Marine Biological Research RAS, Sevastopol, Russia 10:00 - 10:25 The review of Trichoplax adhaerens genome: comparative analyses L. L. Moroz. E.University Vodiasova of Florida,, E. Florida,Chelebieva USA; Kovalevsky Institute of Marine Biological Research of RAS, Russia A.O. Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia 10:25 - 10:50 The diversity of cell types in Trichoplax adhaerence: Hidden complexity of a simpler organism? D. Romanova, E. Nevrova A.O. Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia 10:50 - 11:10 Coffee Break 11:10 - 11:45 Complex life cycle: a set of phenotypes on the single genome M. Nesterenko1, V. Starunov1, 2, S. Shchenkov1, 3, A. Dobrovolskij1, K. Khalturin1, 4 1 Saint-Petersburg State University, St. Petersburg, Russia; 2 Zoological Institute of RAS, St. Petersburg, Russia; 3 Kovalevsky Institute of Marine Biological Research of RAS, Russia; 4 Okinawa Institute of science and technology, Okinawa, Japan 11:45 - 12:10 Mirtrons as a possible inherent source of silencing variability P.S. Vorozheykin1, I.I. Titov1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 12:10 - 12:35 Transition transversion ratio in mtDNA is higher in long-versus short-lived mammalians: effects of ROS and replication? A.G. Mikhaylova1, A.A. Mikhaylova1, K. Ushakova1, E. Tretyakov1, A. Yurchenko2, D. Knorre3, I. Mazunin1, A. Reymond5, K. Gunbin1, 4, K. Popadin1, 5 1 The School of Life Sciences, Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 2 Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; 3 The A.N. Belozersky Institute Of Physico-Chemical Biology, MSU, Moscow, Russia; 4 The Institute of Cytology and Genetics of the SB RAS, Novosibirsk, Russia; 5 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland 12:35 - 13:00 The genome and transcriptome of a freshwater bryozoan Cristatella mucedo V. Starunov1, 2, A. Predeus3, Y. Barbitov3, A. Maltseva1, V. Kutyumov1, E. Vodiasova4, E. Chelebieva4, D. Romanova4, A. Ostrovsky1, L. Moroz4 1 Saint-Petersburg State University, St. Petersburg, Russia; 2 Zoological Institute of RAS, St. Petersburg, Russia; 3 Bioinformatics institute, St. Petersburg, Russia; 4 Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia 13:00 - 15:00 Poster session and lunch 15:00 - 15:35 Diversity of genomic variants and population genetics of ethnic and regional groups across Russia

D.V. Zhernakova1,2, V. Brukhin1, S. Malov 1,3, T K. Oleksyk1,4, K. Peter Koepfli1,5, A. Zhuk1, P. Dobrynin1, S. Kliver1, N. Cherkasov1, G. Tamazian1, M. Rotkevich1, K. Krasheninnikova1, I. Evsyukov1, S. Sidorov1, A. Gorbunova1,6, E. Chernyaeva1, A. Shevchenko1, S. Kolchanova1,4, A. Komissarov1, S. Simonov 1, A. Antonik 1, A. Logachev1, D.E. Polev7, A.S. Glotov 7, V. Ulantsev8, E. Noskova8,9, T.K. Davydova10, T.M. Sivtseva10, S. Limborska11, O. Balanovsky12,13,14, V. Osakovsky 10, A. Novozhilov 15, V. Puzyrev16, N. Kropachev17, S.J. O'Brien1 1Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russian Federation; 2University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands; 3Department of Mathematics, St.-Petersburg Electrotechnical University, St.- Petersburg, Russian Federation; 4Biology Department, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico; 5Smithsonian Conservation Biology Institute, National Zoological Park, Washington, D.C. USA; 6I.I. Mechnikov North-Western State Medical University, St. Petersburg, Russian Federation; 7Research Resource Center for Molecular and Cell Technologies, Research Park, Saint-Petersburg State University, St. Petersburg, Russian Federation; 8Computer Technology Department , St.-Petersburg Electrotechnical University, St.-Petersburg, Russian Federation; 9JetBrains Research, St. Petersburg, Russian Federation; 10Institute of Health, North-Eastern Federal University, Yakutsk, Russian Federation.; 11Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation; 12Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russian Federation; 13Research Centre for Medical Genetics, Moscow, Russian Federation; 14Biobank of North Eurasia, Moscow, Russian Federation; 15Department of Ethnography and Anthropology, St. Petersburg State University, St. Petersburg, Russian Federation; 16Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk 634050, Russian Federation; 17Office of the Rector, St. Petersburg State University, St. Petersburg, Russian Federation 15:35 - 16:00 Evolutionary History of Native Americans drown by Deep Learning Approach O. Dolgova, I. Maceda, O. Lao Population Genomics Team, Centre Nacional d’Anàlisi Genòmica, Barcelona, Spain 16:00 - 16:25 Genetic footprints of Medieval nomads on the crossroads of civilizations in Southern Russian A. Mikheyev, E. Batyeva, V. Klyuchniov, Yu. Orlov, N. Moshkov, I. Dmitrievsky, T. Lorentz, T. Tatarinova University of La Verne, CA, USA 23 August

9:00 - 9:35 Genome admixture components accurately predict quantitative functional traits 9:35 - 10:00 Comparisonin plants of evolutionary rates of the regions and nucleotide substitutions in theL. Gentzbittel Allium plasto1, C.mes Ben 1, M. Mazurier1, M.G. Shin2, T. Lorenz3, M. Rickauer1, P. MarjoramD.O. Omelchenko2, S. V.1, 2 , NuzhdinA.A. Krinitsina2, T. 1,V. 2, M.D.Tatarinova Logacheva3 1, 2, M.S. Belenikin3, E.A. Konorov1, 4, S.V. 1 1 1, 2 1Kuptsov , A.P. Seregin , A.S. Speranskaya 2 1 EcoLab, Université de Toulouse, CNRS, Toulouse INP, UPS,2 Toulouse, France; Department of Biological Lomonosov Moscow State University, Moscow, Russia; Skolkovo Institute3 of Science and Technology, Moscow Region,Sciences, Russia; University 3 Moscow of South Instituteern California, of Physics Los and Angeles, Technology, CA, 90089, Moscow USA; Region, Department Dolgoprudny, of Biology, Russia; Division 4 Vavilov of InstituteNatural Sciences,of General University Genetics, of Moscow, La Verne, Russia La Verne, CA, USA 10:00 - 10:25 Single-cell bioinformatics: practical implementations O. Kuleshova A.O. Kovalevsky Institute of Marine Biological Research of RAS, Sevastopol, Russia 10:25 - 10:50 Hidden diversity of myxomycetes: problems and perspectives O.N. Shchepin1, 3, Y.K. Novozhilov1, I.S. Prikhodko2, M. Schnittler3 1 Komarov Botanical Institute of the Russian Academy of Sciences, Saint Petersburg, Russia; 2 St. Petersburg State University, Saint Petersburg, Russia; 3 Institute of Botany and Landscape Ecology, EMA University of Greifswald, Greifswald, Germany 10:50 - 11:10 Coffee Break 11:10 - 11:45 Diel cycle of the tropical air microbiome E.S. Gusareva, E. Acerbi, K.J.X. Lau, A. Wong, S. Kolundžija, P.B.N. Vasantha, R. Purbojati, I. Luhung, J.N. Houghton, D. Miller, N.P.E. Gaultier, C.E. Heinle, M. Clare, V.K. Vettath, C. Kee, S.B.Y. Lim, C. Chenard, W.J. Phung, K.K. Kushwaha, A.P. Nee, A. Putra, D. Panicker, M. Koh, Y.Z. Hwee, S.R. Lohar, H.L. Kim, L. Yang, A. Uchida, D. Moses, A.C. Junqueira, S.C. Schuster Centre for Environmental Life Sciences Engineering, Nanyang Technological University, 60 Nanyang Drive, Singapore 11:45 - 12:10 Microbial diversity in the hot spring Faust Lake, Kunashir Island A. Rozanov1, A. Korzhuk1, 2, S. Peltek1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 12:10 - 12:35 Comparative genome analysis of related Lymantria dispar nucleopolyhedrovirus isolates differing in virulence Yu. Ilinsky1, 2, 3, E. Lunev2, S. Toshchakov2, 4, J. Podgwaite5, V. Martemyanov6, 7 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Immanuel Kant Baltic Federal university, Kaliningrad, Russia; 3 Novosibirsk State University, Novosibirsk, Russia; 4 Winogradsky Institute of Microbiology, Moscow, Russia; 5 USDA Forest Service, Hamden, USA; 6 Institute of systematics and ecology of animals SB RAS, Novosibirsk, Russia; 7 National Research Tomsk State University, Tomsk, Russia 12:35 - 13:00 Opisthorchiidae triad:comparative genomics of the carcinogenic liver flukes using a draft genome of Opisthorchis felineus

Ershov N. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 13:00 - 15:00 Poster session and lunch 15:00 - 15:25 Inferring phylogeny among cryptic lineages of Eisenia nordenskioldi nordenskioldi (Lumbricidae) based on transcriptomic data S.V. Shekhovtsov1, 2, N.I. Ershov1, G.V. Vasiliev1, S.E. Peltek1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Biological Problems of the North FEB RAS, Magadan, Russia 15:25 - 15:50 Comparative analysis of transcriptome from different sympatric morphs of Dolly Varden Salvelinus malma from the Kronotskoe Lake E.A. Konorov1, V.O.Burskaya2, I.V. Artyushin1, V.A. Scobeyeva1, G.N. Markevich3, N. Osman4, S.V. Nuzhdin4 1 Moscow State University, Moscow, Russia; 2 Skolkovo Institute of Science and Technology, Moscow, Russia; 3 Kronotsky Nature Reserve, Yelizovo, Russia; 4 Molecular and Computational Biology, University of Southern California, Los Angeles, USA

SYMPOSIUM «Mathematical modeling and high performance computing in bioinformatics, biomedicine and biotechnology» MM&HPC-BBB-2018 22-24 August 2018

22 August, Wednesday 09:00-13:00 Morning session “Image analysis and mathematical modeling in tomography” Chairpersons: Dr. N.V. Denisova 09:00-09:30 Methods of mathematical modeling in modern diagnostic nuclear medicine Invited talk N.V. Denisova Institute of Theoretical and Applied Mechanics SB RAS, Novosibirsk, Russia 09:30-10:00 Application of Monte Carlo simulations in nuclear medicine imaging Invited talk J. Cal-Gonzales QIMP team, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria. 10:00-10:30 An Algorithm for Tracking C. elegans Body Movement and Muscular Activity in Invited talk Ca2+ Dynamics Video for Tuning and Validation of its Locomotion Simulation A.Yu. Palyanov A.P. Ershov Institute of Informatics Systems SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia 10:30-10:50 Simulation and image reconstruction of the combined Siemens PET/CT and PET/MRI systems H. Kertesz1, A. Renner2, I. Rausch1, T. Beyer1, J. Cal-Gonzalez1 1 QIMP group, Center for Medical Physics and Biomedical Engineering; 2 Digital Image Processing Laboratory, Center for Medical Physics and Biomedical Engineering Medical University of Vienna, Vienna, Austria 10:50-11:10 Coffee break 11:10-11:25 Mathematical phantoms development for computer simulation of the patient examination procedure by a positron emission tomography method M. Ondar1, 2, N. Denisova1 1 Institute of Theoretical and Applied Mechanics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State Technical University, Novosibirsk, Russia 11:25-11:40 The Performance Improvement of the Permutation Test Algorithm for GSEA M. Grishchenko1, A. Yakimenko1, 2, M. Khairetdinov1, 2, A. Lazareva2 1 Institute Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State Technical University, Novosibirsk, Russia 11:40-11:55 Inverse problems in tomography: an evolutionary approach V. Dedok Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia 11:55-12:10 An effective subgradient method for simultaneous restoration and segmentation of blurred images T. Serezhnikova Krasovsky Institute of Mathematics and Mechanics UB RAS; Ural Federal University, Ekaterinburg, Russia 12:10-12:25 Investigation of stopping criterion for OSEM algorithm with application to nuclear medicine L. Jiyu1, N.V. Denisova2, O. Krivorotko1, 3 1 Novosibirsk State University, Novosibirsk, Russia; 2 Khristianovich Institute of Theoretical and Applied Mechanics, Novosibirsk, Russia; 3 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 12:25-12:40 Single-molecular fluorescence spectroscopy in protein folding: a theoretical modeling of multi-color experiments 1, 2 1, 3 1, 2 V.A. Andryushchenko , A.Yu. Palyanov , S.F. Chekmarev 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Thermophysics, SB RAS, Novosibirsk, Russia; 3 Institute of Informatics Systems, SB RAS, Novosibirsk, Russia 12.40-12.55 Intel Software Solutions for Bioinformatics and Life science Andrianova Olga Intel Software, Gold Sponsor 14:00-15:00 Lunch

15:00-19:00 Afternoon session “Inverse problems in biology, medicine and social processes” Chairperson: Prof. A.I. Ilyin, Dr. O.I. Krivorotko

15:00-15:30 High-performance computing and big data in epidemiology Invited talk Sh. Zhang1, S. Kabanikhin2, 3, O. Krivorotko2, 3, Yu. Wang1 1 Tianjin University of Finance and Economics, Tianjin, China; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 15:30-15:50 Supercomputer analysis of social, epidemiological and economic processes O. Krivorotko, S. Kabanikhin Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia 15:50-16:10 Chaos theory as a bioinformatics promissory instrument for a human organism systemic response in-depth study B.G. Vainer1, 2, A.V. Shepelin2 1 Rzhanov Institute of Semiconductor Physics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 16:10-16:30 The possibilities of a Universal computer model in the readiness assessment of the Russian regions resource to epidemics of especially dangerous infectious diseases L. Nizolenko, A. Bachinsky State Research Center of Virology and Biotechnology Vector, Koltsovo, Russia 16:30-16:50 Method of reconstruction of a sequence of non-ribosomal peptides from mass spectra with noise E. Fomin Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 16:50-17:10 Coffee break 17:10-17:30 Inverse modeling of diffusion-reaction processes with image-type measurement data A. Penenko1, 2, Z. Mukatova1, 2, S. Nikolaev3, U. Zubairova3 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 17:30-17:45 Mathematical models of p53–microRNA and their applications S.D. Senotrusova1, 2, O.F. Voropaeva1 1 Institute of Computational Technologies SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 17:45-18:00 Investigation and numerical solving of a mathematical model of intracellular HIV dynamics: from ODE to PDE D. Yermolenko1, 2, O. Krivorotko1, 2, S. Kabanikhin1, 2 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 18:00- 18:15 The optimal control of stochastic differential equations arising in biology, economy and finance E. Kondakova1, O. Krivorotko1, 2, S. Kabanikhin1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 18:15-18:30 Parameters sensitivity of pkpd model parameters V. Lifenko1, D. Voronov2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 18:30-18:45 Inverse problem for partial differential equations in social networks T. Zvonareva1, O. Krivorotko1, 2, S. Kabanikhin1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 18:45-19:00 Identifiability analysis of nonlinear dynamical system Zh. Bektemessov al-Farabi Kazakh National University, Almaty, Kazakhstan

23 August, Thursday

09:00 – Morning session “Big Data in Bioinformatics” 13:05 Chairperson: Dr. E.N. Pavlovskiy, Dr. Yu.L. Orlov

09:00-09:30 Advanced methods in machine learning for bioinformatics Invited talk E.N. Pavlovskiy Novosibirsk State University, Novosibirsk, Russia 09:30-10:00 Bayesian approach to big data processing: problems and perspectives Invited talk M.A. Marchenko Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia 10:00-10:50 Complex information system to study common energy metabolic deficiency under neurodegenerative diseases A. Osypov1, 2, I.Yu. Popova2 1 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 2 Institute of Theoretical and Experimental Biophysics RAS, Pushchino MR, Russia DEPPDB v.3: a portal to study electrostatic and other physical properties of genome DNA and its elements A. Osypov1, 2, G. Krutinin3, E. Krutinina3, P. Beskaravayny3, S. Kamzolova3 1 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 2 Institute of Theoretical and Experimental Biophysics RAS, Pushchino MR, Russia; 3 Institute of Cell Biophysics RAS, Pushchino MR, Russia 10:50-11:10 Coffee break 11:10-11:30 Gene network analysis of complex diseases using GenCoNet O. Zolotareva1, 2, A. Shoshi1, R. Hofestädt1, A. Maier1, V. Ivanisenko3, V. Dosenko4, E. Bragina5 1 Bielefeld University, Bioinformatics / Medical Informatics Department, Bielefeld, Germany; 2 Bielefeld University, International Research Group “Computational Methods for the Analysis of the Diversity and Dynamics of Genoms”, Bielefeld, Germany; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 4 Bogomoletz Institute of Physiology, Kiev, Ukraine; 5 Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia 11:30-11:50 Assessment of software for somatic single nucleotide variant identification using simulated whole-genome sequencing data of cancer W. Kittichotirat1, P. Khongthon1, K. Kusonmano2, S. Cheevadhanarak2 1 Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand; 2 School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand 11:50-12:05 The software and database for Vertebrate imperfect mtDNA repeats annotation. V.A. Shamanskiy1, K.Yu. Popadin1, 2, K.V. Gunbin1, 3 1 School of Life Science, Immanuel Kant Federal Baltic University, Kaliningrad, Russia; 2 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 12:05- 12:20 Deep Bioinformatic Expert System of Analysis, Modeling and Interpretation of Omics BigData of the Human Genome A. Shlikht, N. Kramorenko Far Eastern Federal University, Vladivostok, Russia 12:20-12:35 ARGO_CEL: GPU Based Approach For Potential Composite Elements Discovery In Large DNA Datasets O. Vishnevsky1, 2, A. Bocharnikov1, N. Kolchanov1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 12:35-12:50 Computer system for reconstructing and analyzing random structural models of protein-protein interaction networks N.L. Podkolodnyy1, 2, D.A. Gavrilov3, O.A. Podkolodnaya1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 12:50-13:05 Developing FoldGO, the Tools for Multifactorial Functional Enrichment Analysis D.S. Wiebe1, 2, A.M. Mukhin1, 2, N.A. Omelyanchuk1, 2, V.V. Mironova1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 13:05-14:00 Poster session 14:00–15:00 Lunch

15:00–19:00 Afternoon session “Mathematical modeling of Gene Networks” Chairpersons: Prof. V.P. Golubyatnikov, Dr. N.L. Podkolodnyy

15:00-15:30 The Multiplex Phase Interlocker: A Novel and Robust Molecular Design Invited talk Synchronizing Transcription and Cell Cycle Oscillators T.D.G.A. Mondeel1, C. Linke1, S. Tognetti2, W. Liebermeister3, M. Loog4, H.V. Westerhoff1, F. Posas2, M. Barberis1 1 Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; 2 Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain; 3 Institut für Biochemie, Charité - Universitätsmedizin Berlin, Berlin, Germany; 4 Institute of Technology, University of Tartu, Tartu, Estonia 15:30-16:00 Circadian rhythms: analysis and modeling of gene expression Invited talk N.L. Podkolodnyy1,2 , N.N. Tverdohkleb1,3, O.A. Podkolodnaya1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 16:00-16:20 Population-based mathematical modeling antihypertensive drugs effect using BioUML platform I.N. Kiselev1, 2, A.F. Kolpakova1, 2, F.A. Kolpakov1, 2 1 Institute of Computational Technologies, SB RAS, Novosibirsk; 2 LLC «BIOSOFT.RU», Novosibirsk 16:20-16:40 Estimates from evolutionary algorithms theory applied to gene design A. Eremeev1, 2, A. Spirov1, 3 1 The Institute of Scientific Information for Social Sciences RAS, Moscow, Russia; 2 Omsk Branch of Sobolev Institute of Mathematics SB RAS, Omsk, Russia; 3 The I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia 16:50-17:10 Coffee break 17:10-17:30 HEDGE: Highly accurate GPU-powered protein-protein docking pipeline T. Ermak, A. Shehovtsov, P. Yakovlev BIOCAD, Saint Petersburg, Russia 17:30-17:50 Agent-based modelling of genetic deafness propagation under various sociodemographic conditions S.A. Lashin1, 2, Yu.G. Matushkin1, 2, A.A. Smirnova1, G.P. Romanov3, 4, O.L. Posukh1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 MK Ammosov North-Eastern Federal University, Yakutsk, Russia; 4 Yakut Science Centre of Complex Medical Problems, Yakutsk, Russia 17:50 –18:20 On Existence of a Piecewise Smooth Cycle in one Asymmetric Gene Network Model with Piecewise Linear Equations V. Golubyatnikov1, 2, L. Minushkina2 1 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia On Cycles in Models of Asymmetric Circular Gene Networks V. Golubyatnikov1, 2, N. Kirillova2 1 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia 18:20-18:45 An Inverse Problem in Modelling of a Symmetric Gene Network Regulated by Negative Feedbacks V. Golubyatnikov1, 2, V. Gradov2 1 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia

24 August, Friday

9:00–13:00 Morning session “Analysis of dynamical systems.” Chairpersons: Prof. Sergey Kabanikhin, N. Novikov

09:00-09:30 On the construction of the cerebral hemodynamics model based on clinical data Invited talk A.А. Cherevko1, 4, M.A. Shishlenin2, 3, 4, A.K. Khe1, 4, E.E. Bord4, V.V. Berestov5, K.Y. Orlov5, V.A. Panarin5 1 Lavrentyev Institute of Hydrodynamics of SB RAS, Novosibirsk, Russia; 2 Sobolev Institute of Mathematics of SB RAS, Novosibirsk, Russia; 3 Institute of Computational Mathematics and Mathematical Geophysics, Novosibirsk, Russia; 4 Novosibirsk State University, Novosibirsk, Russia; 5 Meshalkin national medical research center, Novosibirsk, Russia 09:30–09:50 Spatial heterogeneity influences evolutionary scenarios in microbial communities explained by ecological stratification: a simulation study A.I. Klimenko, Yu.G. Matushkin, S.A. Lashin Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia 09:50-10:10 The optimal feedbacks in the mathematical model of chemo-therapy for a nonmonotonic therapy function N. Novoselova Krasovskii Institute of Mathematics and Mechanics, Ural Branch of the RAS, Yekaterinburg, Russia Ural Federal University, Yekaterinburg, Russia 10:10-10:30 Fighting Celiac Disease: Improvement of pH-Stability of Cathepsin L by Computational Design A. Chugunov1, 2, D. Nolde2, V.F. Tereshchenkova3, E.A. Dvoryakova4, I.Yu. Filippova3, E.N. Elpidina4, R. Efremov1, 2 1 National Research University Higher School of Economics, Moscow, Russia; 2 M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia; 3 Chemical Faculty and 4 A.N. Belozersky Institute of Physico-Chemical Biology of M.V. Lomonosov Moscow State University, Moscow, Russia 10:30-10:50 The uniqueness of the solution of the two-dimensional direct problem is the propagation of the action potential along the nerve fiber. A.J. Satybaev1, G.S. Kurmanalieva1, 2 1 Osh Technological University, Osh, Kyrgyzstan; 2 Osh Technological University, Osh, Kyrgyzstan 10:50-11:10 Coffee break 11:10-11:25 Creation of a modular model of metabolic processes in skeletal muscles during moderate physical load using BioUML platform I.N. Kiselev1, 2, V.I. Baranov3, F.A. Kolpakov1, 2 1 Institute of Computational Technologies, SB RAS, Novosibirsk; 2 LLC «BIOSOFT.RU» Ltd., Novosibirsk; 3 Institute of Physiology and Basic Medicine, Novosibirsk 11:25-11:40 Asymptotic stability of solutions in one model of disease M. A. Skvortsova Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia 11:40-11:55 The 2D coefficient inverse problem of the ultrasound waves propagation N. Novikov1, 3, M. Shishlenin1, 2, 3 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 11:55-12:10 Digital heart: personalized medicine and inverse problems A. Prikhodko3, M. Shishlenin1, 2, 3 1 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 12:10-12:25 Siberian supercomputer center as a service for bioinformatics research I. Chernykh, B. Glinskiy, N. Kuchin, S. Lomakin Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 12:25-12:40 Finding Epistasis in High-Throughput Experimental Data L. Aviño Esteban1, N.S. Bogatyreva1, 2, 3, F.A. Kondrashov4, D.N. Ivankov3, 4 1Universitat Pompeu Fabra (UPF), Barcelona, Spain; 2 Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona, Spain; 3 Laboratory of Protein Physics, Institute of Protein Research of the RAS, Pushchino, Moscow region, Russia; 4 Institute of Science and Technology, Klosterneuburg, Austria 12:40-12:55 High performance computing in astrophysics. The organic formation in protostellar disc. I.M. Kulikov Institute of Computational Mathematics and Mathematical Geophysics SB RAS

Plenary lectures 24 of August: 14:00-14:30 Plenary Lecture by Vladimir Zelman, Keck School of Medicine - USC 14:30-15:00 Plenary Lecture by Paul Thompson, ENIGMA - USC 15:00-15:30 Genetics of Aging and Dementia Evgeny Rogaev, University of Massachusetts - USA ,

SYMPOSIUM «Cognitive sciences, genomics and bioinformatics» CSGB-2018 24 August, Friday

09:00-13:00 Registration

09:00-13:00 Morning session

Co-Chairs: - Professor, Academician of RAS L.I. Aftanas, MD, PhD, D.Sci., Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia - Professor Yi-Ling Yang, Department of Biochemical Science and Technology, National Chia-Yi University, Chia-Yi, Taiwan - Professor N.V. Volf, PhD, D.Sci., Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia

09:00-09:30 MicroRNA-210 mediates the hippocampal neurogenesis following traumatic brain injury Y.-L. Yang1, T.-C. Huang2, Y.-Y.P. Wo1, K.-T. Lu2 1 Department of Biochemical Science and Technology, National Chia-Yi University, Chia-Yi, Taiwan; 2 Department of Life Science, National Taiwan Normal University, Taipei, Taiwan 09:30-09:50 The Psychological and EEG Effects of 5-HTTLPR Gene Polimorphism Among People from Different Ethnic Groups in Siberia A.N. Savostyanov1, 2, 3, D.V. Bazovkina2, A.N. Saprygin1, S.S. Tamozhnikov1, T.A. Ausheeva3, A.V. Bocharov1, 3, U.N. Kavai-ool4, A.G. Karpova5, G.G. Knyazev1 1 Institute of Physiology & Basic Medicine, Novosibirsk, Russia; 2 Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia; 4 Tuvan State University, Kyzyl, Russia; 5 North-Eastern Federal University, Yakutsk, Russia 09:50-10:20 Effect of 5-HTTLPR on connectivity and topological properties of resting state EEG networks G. Knyazev, E. Proshina, A. Savostyanov, A. Bocharov Institute of Physiology and Basic Medicine, Novosibirsk, Russia 10:20-10:40 Impact of the Intellectual Environment of Professional Activity on Resting State EEG in Older Adults N. Volf 1, 2, E. Privodnova1 1 Federal State Budgetary Scientific Institution «Scientific Research Institute of Physiology and Basic Medicine», Novosibirsk, Russian Federation; 2 Novosibirsk State University, Novosibirsk, Russian Federation 10:40-11:00 Vitamin D3 affective-related disorders and perimenopause J. Fedotova1, 2, T. Dudnichenko3 1 I.P. Pavlov Institute of Physiology RAS, St. Petersburg, Russia; 2 ITMO University, St. Petersburg, Russia; 3 North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

11:00-11:15 Coffee-break

11:15-11:30 Psychophysiological predictors of effective adaptation to the allostatic load of the mountain climbers S. Krivoschekov1, E. Nikolaeva2, E. Vergunov1, N. Balioz1, Yu. Bobrova3 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Herzen State Pedagogical University, Saint-Petersburg, Russia; 3 Novosibirsk State University of Economics and Management, Novosibirsk, Russia 11:30-11:45 Interference Reconditioning after Visual Memory Training in Older Adults О.M. Razumnikova1, 2, A.A.Yashanina1, 2, V.A. Kagan2 1 Research Institute of Physiology and Basic Medicine, Novosibirsk; 2 Novosibirsk State Technical University, Russia 11:45-12:05 Reconstruction of Leptin and Dopamin Molecular Counter-Regulation in Glutamatergic Hippocampal Synapses A.L. Proskura, T.A. Zapara Institute of Computational Technologies of SB RAS, Novosibirsk, Russia 12:05-12:25 Disruption of D2R x DISC1 binding prevents conditioned place preference induced by morphine in mice M.V. Starostina1, N.S. Sorokina1, T.V. Lipina2, 3 1 Institute of Molecular Biology Biophysics, Novosibirsk, Russia; 2 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia 12:25-12:45 Arranging the High-Confidence MicroRNA Binding Regions into Web Tool for Analyzing Variants in Diagnostic Next Generation Sequencing O. Plotnikova1, M. Skoblov1, 2 1 Moscow Institute of Physics and Technology, Moscow, Russia; 2 Research Centre for Medical Genetics, Moscow, Russia 12:45-13:05 Sleep disorders and gene NPAS2 polymorphism in male population in Russia/Siberia: MONICA-psychosocial Study V. Gafarov1, 2, I. Gagulin1, 2, A. Gafarova1, 2, D. Panov1, 2, E. Krymov1, 2, M. Voevoda1, 2, V. Maximov1, 2, E. Gromova1, 2 1 NIITPM – Branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Collaborative Laboratory оf Cardiovascular Diseases Epidemiology, Novosibirsk, Russia 13:05-13:25 How have our clocks evolved? Adaptive and demographic history of the out-of- African dispersal told by the genetic markers of morning-evening preference A.A. Putilov1, V.B. Dorokhov2, A.N. Puchkova2, 3, D.S. Sveshnikov4, M.G. Poluektov5, O.G. Donskaya1, L.P. Zakharenko6 1 Institute of Molecular Biology and Biophysics, Novosibirsk, Russia; 2 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 3 Pushkin State Institute, Moscow, Russia; 4 Peoples’ Friendship University of Russia, Moscow, Russia; 5 I.M. Sechenov 1st Moscow State Medical University, Moscow, Russia; 6 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

13:00-14:00 Lunch break

15:30-19:00 Evening session

Co-Chairs: - Professor Hung-Ming Chang, Taipei Medical University, Taipei, Department of Anatomy and Cell Biology, Taiwan - M.A. Tikhonova, PhD, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia - N.P. Bondar, Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia

15:30-15:50 Plasmon-activated water is an effective agent in suppressing the progression of dental, metabolic, and neurodegenerative disorders H.-M. Chang1, T.Y. Renn2, Y.C. Liu3, F.D. Mai3, L.Y. Chen4 1 Department of Anatomy and Cell Biology, Taipei Medical University, Taipei, Taiwan; 2 Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan; 3 Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei, Taiwan; 4 Department of Anatomy, Chung Shan Medical University, Taichung, Taiwan

15:50-16:10 Ionic imaging and bio-energetic analysis of club drug-induced cognitive deficiency by time-of-flight secondary ion mass spectrometry (TOF-SIMS) F.-D. Mai1, S.-C. Youn2, 3, L.-Y. Chen3, R.-J. Chiou4, T.-J. Lai2, W.-C. Liao3, H.-M. Chang4 1 Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 2 Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan; 3 Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan; 4 Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 16:10-16:30 Innovatively therapeutic strategy on Alzheimer’s disease by daily drinking plasmon- activated water C.H. Cheng1, K.J. Lin2, C.P. Yang1, Y.C. Liu1, C.J. Hu3, 4 1 Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei, Taiwan; 2 Department of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; 3 Department of Neurology, Taipei Medical University, Taipei, Taiwan; 4 Department of Neurology and Dementia Center, Shuang Ho Hospital, New Taipei City, Taiwan 16:30-16:50 Neuroprotective effects of ceftriaxone: insights from in vitro and in vivo models M.A. Tikhonova1, 2, T.G. Amstislavskaya1, 2, H. Kunugi3, Y.J. Ho4 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 National Center of Neurology and Psychiatry, Tokyo, Japan; 4 Chung Shan Medical University, Taichung City, Taiwan, R.O.C 16:50-17:10 Cystatin C as regulator of autophagy in brain of transgenic mice with model of Parkinson’s disease T.A. Korolenko1, A.B. Shintyapina2, A.B. Pupyshev1, V.M. Belichenko1, E.L. Zavjalov3, T.G. Amstislavskaya1, 4, M.A. Tikhonova1, 4 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Institute of Molecular Biology and Biophysics of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 4 Novosibirsk State University, Novosibirsk, Russia 16:50 – 17:10 Coffee-break

17:10 -17:25 The Potential Impact of Periodontitis on the Pathogenesis of Parkinson's Disease and Cognitive Deficits T.Y. Renn1, L.Y. Chen2, H.-M. Chang3 1 Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan; 2 Department of Anatomy, Chung Shan Medical University, Taichung, Taiwan; 3 Department of Anatomy and Cell Biology, Taipei Medical University, Taipei, Taiwan

17:25-17:40 Revealing the basis of energy metabolic deficiency common to neurodegenerative diseases with differential expression meta-analysis A. Osypov1, 2, I. Yu. Popova2 1 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 2 Institute of Theoretical and Experimental Biophysics RAS, Pushchino MR, Russia 17:40-17:55 Consequences of early life stress in mice: transcriptional and epigenetic hallmarks in frontal cortex and hippocampus N.P. Bondar1, 2, A.A. Lepeshko1, 2, N.I. Ershov1, V.V. Reshetnikov1, Yu.A. Ryabushkina1, 2, T.I. Merkulova1, 2 1 Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia; 2 National Research Novosibirsk State University, Novosibirsk, Russia 17:55-18:15 A system for remote recognition of emotions from a facial expression. G.R. Khazankin, A.N. Malinin, I.S. Shmakov. Scientific-Research Institute of Physiology and Basic Medicine, Novosibirsk State University, Novosibirsk, Russia

18:15-18:30 Closing ceremony Time Name Title 22 August 2018 Sino-Russian Workshop on Integrative Bioinformatics and Systems Biology 9:00-13:00 Section: Computer genomics and post-genomic technologies Chairs: Prof Y.L.Orlov (Russia), Prof. Hong-Yu Zhang, Huazhong Agricultural University, Wuhan (China) 9:00-9:35 Prof. Ming Chen Non-coding RNA world and bioinformatics Keynote Zhejiang University, China study 9:35–10:10 Prof. Dong Li Knowledge mining from large scale Institute of Life Omics, AMMS, 38 Life Science Park Road, protein-protein interaction datasets at Changping district, , China the era of big data 10:10–10:30 A.Y. Filatova Widely-expressed and conserved long Medical-Genetics Center, Moscow, Russia noncoding RNAs LINC00493 and LINC01420 influence on cell physiology 10:30–10:50 V. Akulova, V. Sharov, Yu. Putintseva, N. De novo Sequencing, Assembly and Oreshkova, S. Feranchuk, D. Kuzmin, I. Pavlov, K. Annotation of Armillaria Krutovsky borealis Genome Siberian Federal University, Krasnoyarsk, Russia Limnological Institute SB RAS, Irkutsk, Russia University of Göttingen, Germany VIGG, RAS, Moscow, Russia; Texas A&M University, USA 10:50–11:10 Coffee-break 11:10–11:35 Prof. Guoliang Li Digestion-Ligation-Only Hi-C, a simple, Invited talk Huazhong Agricultural University, Wuhan, China cost-effective, and highly efficient method for Chromosome Conformation Capture 11:35-11:55 T.G. Amstislavskaya, Y.L. Yang, C.P. Jen Developing the protein-concentrating Scientific Research Institute of Physiology and Basic Medicine, nanofluidic chips for early diagnostics of and Novosibirsk State University, Novosibirsk, Russia Department of Biochemical Science and Technology, National neurodegenerative disorders Chia-Yi University, Taiwan ROC Department of Mechanical Engineering, National Chung Cheng University, Chia-Yi, Taiwan ROC 11:55–12:15 Yanshi Hu Analyzing the genes related to Zhejiang University, China Alzheimer's disease via a network and pathway-based approach 12:15–12:35 A. Beletic, I. Moric, V. Djordjevic "Mining" for the Alpha-1-Antitrypsin Center for Medical Biochemistry, Clinical Center of Serbia, Deficiency in the Population of Serbia - Molecular Genetics and Genetic Engineering, University of Experience in the Implementation of an Belgrade, Belgrade, Serbia Integrative Diagnostic Algorithm 12:35–12:55 S.P. Tsarev, M. Senashova, M. Sadovsky Fast search of long approximate repeats Siberian Federal University, Krasnoyarsk, Russia in DNA sequences with bounded indel Institute of computational modelling SB RAS, Krasnoyarsk, density Russia 12.55-13.00 Closing remarks of section, announces 13.00-14.00 Lunch 14:00-18:10 Section: Integrative bioinformatics and data analysis in systems biology Chairs: Prof. Ming Chen, Prof Guoliang Li (China) 14:00-14:35 Prof. Hong-Yu Zhang Evolutionary and genetic features of drug Keynote Huazhong Agricultural University, Wuhan, China targets 14:35-15:00 Prof. Dr. Ralf Hofestädt Petri-nets for modelling and simulation of Bielefeld University, Germany biological networks 15:00-15:20 Prof. Xiaodong Zhao Epigenetic codes and their implications in Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong stem cell biology: an insight derived from University, China deep sequencing analysis 15:20-15:40 Marko J. Djordjevic, M.R.Djordjevic, E.Zdobnov A Kolmogorov-Smirnov based approach Institute of Physiology and Biochemistry, University of Belgrade, for predicting targets of transcription Serbia 15:40-16:00 Alexander Kel Pan-regulome: Integration of knowledge GeneXplain GmbH, Wolfenbuettel, Germany on gene regulation. Transnational Institute of Chemical Biology and Fundamental Medicine SB cooperation RAS, Novosibirsk, Russia Time Name Title 16:00-16:20 Wenyi Wu Genome-wide analysis of long non-coding Zhejiang University, China RNAs responsive to multiple nutrient stresses in Arabidopsis thaliana 16:20-16:35 Cong Feng Quantifying genome sequence Zhejiang University, China repeatability by Repeater 16:35-16:50 Qi Chen Versatile interactions and bioinformatics Zhejiang University, China analysis of non-coding RNAs 16.50-17.10 Coffee-break 17.10-17.30 Tikhonova M.A., Amstislavskaya T.G., Ho Y.J. Drug reposition as a promising strategy in Scientific Research Institute of Physiology and Basic Medicine, therapy of cognitive deficits at and Novosibirsk State University, Novosibirsk, Russia neurodegenerative disorders Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Chung Shan Medical University, Taichung City, Taiwan, R.O.C.. 17.30-17.50 Prof. Qi Dai Bioinformatics Platform for Genomic Zhejiang Sci&Tech University, China Island Detection and Analysis 17:50-18.10 Hangzhou Lifereal Biotechnology Co., Ltd., China Novel PCR technology Closing remarks of the section 18:00-19:00 Poster session

23 August 2018 Sino-Russian Workshop on Integrative Bioinformatics and Systems Biology 9:00-13:00 Section: Bioinformatics Prof. Ralf Hofestädt (Germany), Prof. Ming Chen (China) 9:00-9:35 Prof Hung-Ming Chang Exploring the potential impacts of maternal Invited Taipei Medical University, Department of Anatomy and Cell early-life sleep deprivation on cognitive and Biology, Taiwan R.O.C. metabolic function of the offspring 9:35–10:00 Mikhail A. Orlov T7-like bacteriophage promoters: stress- Institute of Cell Biophysics, RAS, Pushchino, Russia induced duplex destabilization suggests a role in replication 10:00–10:20 Konstantin V. Gunbin Heterotachy in evolution of proteins Novosibirsk State University, Novosibirsk, Russia associated with mitochondrial function in Baltic Federal University, Kaliningrad, Russia rodents and primates: opposite protein functions but common ecological role 10:20–10:45 Vladimir N. Babenko Analysis of alternative splicing by RNA-seq Novosibirsk State University, Novosibirsk, Russia data 10:50–11:10 Coffee-break

23 August 2018 Special Section: Neuronet Initiative Project 11:10-12:30 Special Section: Neuronet Initiative Project Moderators - Prof. Yuriy Orlov, Dr Alexander Savostyanov 11:10-11:20 Yuriy Orlov, Alexander Savostyanov Neuronet Initiative in Russia 11:20-11:40 Alexey Kolodkin, Hans V. Westerhoff, Matteo Infrastructure Systems Biology Europe Barberis (ISBE): Emergence of Innovative Systems Infrastructure for Systems Biology Europe (ISBE), Vrije Biology Servicing Universiteit Amsterdam 11:40-12:00 Anna A. Igolkina, Maria G. Samsonova Analysis of gene expression variance in St.Petersburg Polytechnical University, St.Petersburg, Russia schizophrenia using structural equation modeling 12:00-12:20 Olga Krebs European bioinformatics infrastructure HITS, Heidelberg, Germany 12:20-12:40 Maxim Zakhartsev System biology models in neurobiology Norway 12:40-13:00 A.C. Tsai Using drift diffusion model to understand NeuroImaging group at the Institute of Statistical Science, age related differences in inhibitory control Academia Sinica, Taipei, Taiwan. 13.00-14.00 Lunch

23 August 2018 14:00-16:00 Round table. Bioinformatics and educational programs. Moderators - Prof. R.Hofestädt, Dr O.Krebs(Germany), Prof. M.Chen (China), Prof. Y.L. Orlov, Prof. M.P.Fedoruk, Prof. A.G.Okunev, Prof. N.A.Kolchanov (Russia), Prof. Ivo Grosse (Germany) 14:00–14:10 Prof. M.P. Fedoruk Novosibirsk State University: education Novosibirsk State University programs and international cooperation 14:10-14:20 Dmitri A. Afonnikov Education at agrobiology program at Novosibirsk State University Novosibirsk University: new perspectives International experience in education programs 14:20–14:35 Prof. Tatiana V. Tatarinova, Cecile Ben Bioinformatics: science of a toolbox? University of La Verne, USA University of Toulouse, France 14:35-14:50 Marko J. Djordjevic Integrating computational systems biology and Belgrade University, Serbia bioinformatics in research and education 14:50–15:05 Prof. H.V. Westerhoff Teaching Medicine and Biology through Synthetic Systems Biology and Nuclear Organization, Systems Biology University of Amsterdam; Molecular Cell Physiology, Vrije Universiteit Amsterdam 15:05-15:15 Prof. Ming Chen Education programs on bioinformatics in China Zhejiang University, China 15:15-15:20 Leonard Lipovich Teaching applied bioinformatics to graduate Wayne University, USA and medical students: experience at Wayne State University and internationally 15:20-15:30 Ivo Grosse Education programs in Germany Martin Luther University Halle-Wittenberg, Germany Educational programs in Russia 15:30-15:40 Prof. Vsevolod Ju. Makeev Bioinformatics and educational programs in Vavilov Institute of General Genetics, Moscow State genetics at Moscow State University University, Moscow, Russia 15:40-15:45 S.A. Lashin Bioinformatics education program at the Novosibirsk State University Department of Informational Technologies, Novosibirsk State University 15:45-15:50 Maxim Korolev Medical informatics problems and education Institute of Cyt.&Genetics SB RAS, Novosibirsk, Russia 15:50-16:35 Discussion (5 minutes each) Round table Prof. Alexey G. Okunev Bioinformatics and educational programs at discussion (up Novosibirsk State University, Novosibirsk, Russia Novosibirsk State University to 5 min) Prof. Dr. Ralf Hofestädt German-Chinese network on bioinformatics Bielefeld University, Germany and education A.V.Timofeev Chemogenomics as an essential academic University, Russia discipline in the structure of modern biotechnological education Dr. Olga G. Maslennikova International educational program on Tomsk State University, Tomsk, Russia bioinformatics at Tomsk University, Russia Prof. Xiaodong Zhao Education programs at Shanghai Jiao Tong Shanghai Center for Systems Biomedicine, Shanghai Jiao University Tong University, China Alexey Kolodkin Education programs in Europe and Russia Infrastructure for Systems Biology Europe (ISBE), Institute of Cytology&Genetics SB RAS, Novosibirsk, Russia A. Ivashchenko, R. Niyazova, Sh. Atambayeva, The experience of training specialists in A. Pyrkova bioinformatics in Kazakhstan Kazakhstan Tatiana Tatarinova, Ancha Baranova, Vikas Graduate certificate programs for careers in Chandhoke bioinformatics and biomedicine: Experience of George Mason University, Virginia, USA George Mason University Anatoly Shlikht Russian portal of omics data based on Far East federal University, Vladivostok, Russia databases and knowledge bases technology Coffee-break

POSTERS SECTION «Systems Computational Biology» 21 August, Tuesday

R SCB1 Methane utilization in Methylomicrobium alcaliphilum 20Z : New routes of C1- metabolism Ilya R. Akberdin1,2,3,*, Merlin Thompson1, Richard Hamilton1, David Collins1 and Marina G. Kalyuzhnaya1,4 1 Department of Biology, San Diego State University, San Diego, USA; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia; 4 Viral Information Institute, San Diego State University, San Diego, USA SCB2 A Catalog of Human Genes and a Gene Network Controlling Feeding Behavior and Body Weight Ignatieva E.V. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia SCB3 Infrastructure Systems Biology Europe (ISBE): Emergence of Innovative Systems Biology Servicing Alexey Kolodkin1,2,3,4,5, Anna Maria Colangelo6, Lilia Alberghina6, Raju Prasad Sharma7, Vikas Kumar7, Danyel Jennen8, Jacco J. Briede8 and Hans V. Westerhoff 1,4,5,9 1-Infrastructure for Systems Biology Europe (ISBE); 2-Luxembourg Centre for Systems Biomedicine, University of Luxembourg, LUXEMBOURG; 3-Federal Centre Institute of Cytology and Genetics of Siberian Division of the Russian Academy of Sciences, RUSSIA; 4- Molecular Cell Physiology, VU University Amsterdam, THE NETHERLANDS; 5-Synthetic Systems Biology, SILS, University of Amsterdam, THE NETHERLANDS; 6-SysBio Centre of Systems Biology, University of Milano-Bicocca, ITALY; 7-Center of Environmental Food and Toxicological Technology (TecnATox), Departament d'Enginyeria Química, Universitat Rovira i Virgili, Spain; 8-Department of Toxicogenomics, Maastricht University, THE NETHERLANDS; 9-Manchester Centre for Integrative Systems Biology, UK SCB4 The Metabolic Pathways, Metabolites and Signal Transduction Chanchal K Mitra Department of Biochemistry, University of Hyderabad, 500046 Hyderabad, India SCB5 Pulse Wave Velocity Measurement in the Human Radial Artery Boris G. Vainer Rzhanov Institute of Semiconductor Physics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia SCB6 GENE NETWORKS OF HUMAN HEARING IMPAIRMENTS: RECONSTRUCTION AND ANALYSIS V.I. Zamyatin 1,2* , Z.S. Mustafin 1,2 , E.V. Ignatieva 1,2 , Yu.G. Matushkin 1,2 , O.L. Posukh 1,2 , S.A. Lashin 1,2 1 Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia;2 Novosibirsk State University, Novosibirsk, Russia SCB7 Circadian Rhythm of Biological Processes in Mouse Liver and Kidney: Analysis of RNA-seq and Ribosome Profiling Data N.L. Podkolodnyy 1,2* , N.N. Tverdohkleb 1,3 , O.A. Podkolodnaya 1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 2 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia 3 Novosibirsk State University, Novosibirsk, Russia

SECTION «Systems Biology of Aging» 21 August, Tuesday SBA1 Maintaining pH of the Culture Medium in Cytogerontological Experiments: Effect on the Cell Viability and the Shape of the Cells' Survival Curve Galina V. Morgunova, A.A. Klebanov, A.N. Khokhlov School of Biology, Lomonosov Moscow State University, Moscow, Russia SBA2 Approximation of the Growth and Survival Curve of a Non-Subcultured Cell Culture within the Framework of the Stationary Phase Aging Model A.A. Klebanov, G.V. Morgunova, A.N. Khokhlov School of Biology, Lomonosov Moscow State University, Moscow, Russia SBA3 Neurotrophin signaling pathway in development of AMD-like retinopathy Mikhail D. Matytsin, O. S. Kozhevnikova, E. A. Rudnitskaya, D. V. Telegina Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia SBA4 Contribution of Neuroinflammation to the Development of Alzheimer's Disease-Like Pathology in OXYS Rats Olga Yu. Koneva1,2, E.A. Rudnitskaya1, Yu.V. Rumyantseva1, N.A. Stefanova1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia SBA5 Analysis of metabolic pathways associated with neurogenesis in the retina of OXYS rat –model of age-related macular degeneration Darya V. Telegina, O.S. Kozhevnikova, N.G. Kolosova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia SBA6 Alterations of Neurogenesis during Development of Alzheimer’s Disease-Like Pathology in OXYS Rats Alena O. Burnyasheva, N.G. Kolosova, N.A. Stefanova, E.A. Rudnitskaya Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia SBA7 Search for single-nucleotide polymorphisms associated with accelerated senescence in OXYS rats Vasily Devyatkin1, 2, O. Redina1, N. Muraleva1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia SBA8 Apoptosis and autophagy alterations are involved in the development of Alzheimer disease-like parthology in OXYS rats Gleb K. Suvorov, D. V. Telegina1, N. A. Stefanova1. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russi SBA9 MAPK signaling pathway in development of Alzhemer's disease Natalya Muraleva

Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

SYMPOSIUM «Systems biology of DNA repair processes and programmed cell death» SbPCD-2018 21 August 2018 SbPCD1 DNA polymerases beta and lambda: gap-filling synthesis on the intact and damaged DNA templates in base excision repair E.A. Maltseva, L.V. Starostenko, O.I. Lavrik, N.I. Rechkunova Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia SbPCD2 Disaccharide nucleosides as inhibitors of DNA repairing enzymes M. Drenichev1, A. Komarova2, 3, N. Dyrkheeva2, I. Kulikova1, V. Oslovsky1, O. Zakharova2, A. Zakharenko2, S. Mikhailov1, O. Lavrik2 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2 Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia; 3 Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia SbPCD3 PARPs and PARGs orchestrate the assembly/disassembly of FUS/Poly(ADP-ribose) compartments at DNA damage sites and FUS translocation to cytoplasmic stress granules Singatulina1, L. Hamon2, M. Sukhanova1, A. Bouhss2, O. Lavrik1, D. Pastré2 1 Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia; 2 Université d’Évry-Val-d’Essonne, Evry, France SbPCD4 Development of Tdp1 inhibitors based on natural biologically active compounds A.A. Chepanova1, A.L. Zakharenko1, O.D. Zakharova1, T.M. Khomenko2, E.V. Suslov2, N.S. Li-Zhulanov2, K.P. Volcho2, O.I. Lavrik1 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Institute of Organic Chemistry SB RAS, Novosibirsk, Russia SbPCD5 Activity of single nucleotide polymorphic variants of human AP-endonuclease 1 A.T. Davletgildeeva1, 2, I.V. Alekseeva1, O.S. Fedorova1, 2, N.A. Kuznetsov1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia SbPCD6 Modulatory effect of PAR on PARP1-YB-1 interactions K. Naumenko1, 2, E. Alemasova2, O. Lavrik1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Chemical Biology and Fundamental Medicine SB RAS, Russia SbPCD7 Comparative analysis of lactaptin produced in bacterial and eukaryotic cells. Purification and activity O. Chinak1, O. Volkova2, T. Belovezhec2, A. Gorchakov2, A. Tkachenko1, E. Kuligina1, V. Ricter1, O. Koval1, 3 1 Institute of Chemical Biology and Fundamental Medicine, SB, RAS, Novosibirsk, Russia; 2 Institute of Molecular and CellularBiology SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia SbPCD8 Tyrosyl-DNA phosphodiesterase 1 (Tdp1) and its natural mu-tant SCAN1 inhibitors as prototypes of drugs E. Mamontova1, 2, K. Kovaleva2, 3, A. Zakharenko1, O. Yarovaya3, J. Reynisson4, O. Zakharova1, E. Ilina1, O. Lavrik1, 2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Organic Chemistry SB RAS, Novosibirsk, Russia; 4 School of Chemical Sciences, University of Auckland, New Zealand SbPCD9 The influence of pH on damaged DNA processing by human apurinic/apyrimidinic endonuclease 1 I. V. Alekseeva1*, A. Bakman 2, Yu. N. Vorobjev1, O. S. Fedorova1,2 , N. A. Kuznetsov 1,2 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia SbPCD10 CRISPR/Cas9-mediated Cleavage of Protospacer with DNA Damage I. Vokhtantsev 1 , L. Kulishova 2 , A. Endutkin 1,2 , D. Zharkov 1,2 * 1 Novosibirsk State University, Novosibirsk, Russia.2 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia SECTION «Genomics, transcriptomics and bioinformatics» 21 August GTB1 Analysis of Repetitive DNA Sequences in Genomes of Porodaedalea niemelaei, P. chrysoloma and Armillaria borealis A. Aksyonova1, Y. Putintseva1, N. Oreshkova1, 2, I. Pavlov1, 2, Y. Litovka3, K. Krutovsky1, 6, 7, 8 1Siberian Federal University, Krasnoyarsk, Russia; 2V. N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3M. F. Reshetnov Siberian State Aerospace University, Department of Silviculture, Krasnoyarsk, Russia; 4Georg-August University of Göttingen, Department of Forest Genetics and Forest Tree Breeding, Göttingen, Russia; 5Vavilov Institute of General Genetics RAS, Moscow, Russia; 7Texas A&M University, College Station, Texas, USA GTB2 Genome De Novo Sequencing, Assembly and Functional Annotation of Pathogenic Fungi Armillaria borealis V. Akulova1*, V. Sharov1, Yu. Putintseva1, N. Oreshkova1, 2, S. Feranchuk1, 3, 4, D. Kuzmin1, I. Pavlov1, 2, K. Krutovsky1, 5, 6, 7 1 Siberian Federal University, Krasnoyarsk, Russia; 2 V. N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3 Irkutsk National Research Technical University, Irkutsk, Russia; 4 Limnological Institute SB RAS, Irkutsk, Russia; 5 Georg-August University of Göttingen, Göttingen, Germany; 6 Vavilov Institute of General Genetics RAS, Moscow, Russia; 7 Texas A&M University, College Station, USA GTB3 Identification of Targets Genes for miRNAs of the Pathogenic Fungus Fusarium oxysporum in a De Novo Transcriptome Assembly of the Siberian Larch (Larix sibirica Ledeb.) V. Biriukov1*, N. Oreshkova1, 2, Yu. Putintseva1, K. Krutovsky1, 3, 4, 5 1 Siberian Federal University, Krasnoyarsk, Russia; 2 V. N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3 Georg-August University of Göttingen, Göttingen, Germany; 4 Vavilov Institute of General Genetics RAS, Moscow, Russia; 5 Texas A&M University, College Station,, USA GTB4 Genome rearrangements in bacterial genomes O. O. Bochkareva1*, M.S. Gelfand1,2,3,4 1 Institute of Information Transmission Problem RAS, Moscow, Russia; 2 Lomonosov State University, Moscow, Russia; 3 Higher School of Economics, Moscow, Russia; 4 Skolkovo Institute of Science and Technology, Moscow, Russia GTB5 Minor variation in the 3′ downstream region of eGFP reporter gene substantially increases level of its expression in mouse and human cells Lidiya V. Boldyreva1*, Lyubov A. Yarinich1,2, Elena N. Kozhevnikova1, Alexey V. Pindyurin1,2 1Institute of Molecular and Cellular Biology of the SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia GTB6 Study of Bioresources of Salt Lakes of Novosibirsk Region A. Bryanskaya1*, Yu. Uvarova1, A. Rozanov1, E. Lazareva2, O. Taran3, T. Ivanisenko1, S. Peltek1 1Federal Research Center "Institute of Cytology and Genetics of the Siberian Branch of the RAS", Novosibirsk, Russia; 2Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russia; 3Boreskov Institute of Catalysis SB RAS, Novosibirsk, Russia GTB7 Functional analysis of SNVs affecting splicing in congenital aniridia A. Filatova1, T. Vasilyeva1, M. Skoblov1, 2, A. Voskresenskaya3, A. Marakhonov1, 2, R. Zinchenko1,4 1 Research Center for Medical Genetics, Moscow, Russia; 2 Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia; 3 Cheboksary branch of S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary, Russia;4 Pirogov Russian National Research Medical University, Moscow, Russia GTB8 The analysis of extracellular matrix genes` functional activity in carotid artery plaque I.А. Goncharova1*, А.V. Markov1, А.А. Sleptsov 1, Y.А. Koroleva1, D.V. Sharysh3, А.А. Zarubin3, N.R. Valiahmetov1, E.F. Muslimova2, D.S. Panfilov2, B.N. Kozlov2, S.А. Afanasiev2, V.P. Puzyrev 1,3, М.S. Nasarenko1,3 1 Research Institute of Medical Genetics, Tomsk, Russia ; 2 Research Institute of cardiology, Tomsk, Russia; 3 Siberian State Medical University, Tomsk, Russia GTB9 GWAS-MAP: a platform for storage and analysis of the results of thousands of genome- wide association scans D.D. Gorev* 1,2,3 , T.I.Shashkova 1,2,3, E.Pakhomov 2, A. Torgasheva 4, L.Klaric 5, 6, A. Severinov 1,3, S.Sharapov 2,4, D.G. Alexeev 1,2, Y.S.Aulchenko 2,3,4 1 LLC ‘Knomics’, Moscow, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Moscow Institute of Physics and Technology, Moscow, Russia; 4 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 5 Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 6 Genos Glycoscience Laboratory, Zagreb, Croatia GTB10 Mining of Non-Teleost Fish Transcriptomes and Genomes Uncovers the Evolutionary History of Immunoglobulin Light Chains S.Guselnikov1,2*, K.Baranov1, N.Chikaev1, A.Najakshin1, S.Kulemzin1, A.Makunin1, V.Trifonov1, 2, A.Taranin1,2 1Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia GTB11 PyMPFA: python pipeline for massively parallel functional assays used for characterization of DNA regulatory elements A. Ivankin1*, A. Pindyurin1,2 1 Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia GTB12 Motif analysis of regulatory SNPs reveals Krueppel-like tran-scription factors as putative tumor suppressors in colorectal carcinoma O. Kel-Margoulis1*, A. Kel1, 2, E. Wingender1, 3 1 geneXplain GmbH, Wolfenbuettel, Germany; 2 Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia; 3 Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia GTB13 Genomic organization of serratiochelin cluster in the environmental and clinical strains of Serratia marcescens I. Khilyas1*, M. Sharipova1, L. Bogomolnaya1,2 1 Institute of Fundamental medicine and biology KFU, Kazan, Russia; 2 Texas A&M University Health Science Center, Bryan, TX, USA GTB14 Osteogenic-Related Gene Expression by Human Adipose-Derived Mesenchymal Stem Cells I. Khlusov1,2, L. Litvinova2*, K. Yurova2, V. Shupletsova2, O. Khaziakhmatova2, E. Melashchenko2, L.Pokrovskaya1 1Tomsk State University, Tomsk, Russia; 2 Immanuel Kant Baltic Federal University, Kaliningrad, Russia GTB15 Siamese Neural Networks for Metagenomics Binning B. Kirillov1* 1 Skolkovo Institute of Science and Technology, Moscow, Russia GTB16 Evolution of Mitochondrial Genomes in Three Closely-Related Armillaria Species A. Kolesnikova1, Y. Putintseva1, S. Jain1, N. Oreshkova1, 2, I. Pavlov1, 2, V. Sharov1, D. Kuzmin1, S. Makolov1, K. Krutovsky1, 3, 4, 5* 1Siberian Federal University, Krasnoyarsk, Russia; 2V. N. Sukachev Institute of Forest SB RAS, Krasnoyarsk, Russia; 3Georg-August University of Göttingen, Göttingen, Germany; 4N. I. Vavilov Institute of General Genetics RAS, Moscow, Russia; 5Texas A&M University, College Station, USA GTB17 Molecular evolution analysis of the antioxidant system and heme metabolism in helminths D. Konstantinov1,2*, M. Lvova2, A. Doroshkov2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia GTB18 The overlapped motifs co-occurrence in ChIP-seq data V.G. Levitsky1,2*, D.Yu. Oshchepkov1, E.V. Zemlyanskaya1,2, V.V. Mironova1,2, E.V. Ignatieva1,2, O.A. Podkolodnaya1, T.I. Merkulova1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia2 Novosibirsk State University, Novosibirsk, Russia GTB19 Mutation load in carotid paragangliomas E. Lukyanova1, A. Snezhkina1*, D. Kalinin2, M. Fedorova1, E. Pudova1, Z. Guvatova1, S. Kharitonov1, N. Melnikova1, G. Krasnov1, A. Dmitriev1, A. Kudryavtseva1,3 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia; 3National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia GTB20 Multiple Omics Ageing Clocks Erin Macdonald-Dunlop1*, Peter K Joshi1, James F Wilson1,2 1: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom; 2: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, United Kingdom GTB21 Expression of Fusarium oxysporum Genes Upon Infection of Linum usitatissimum Plants R. Novakovskiy1*, G. Krasnov1, T. Rozhmina1,2, P. Kezimana1,3, N. Melnikova1, A. Dmitriev1 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2 All-Russian Research Institute for Flax, Torzhok, Russia; 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia GTB22 Two-step emulsion PCR to prevent formation of the chimeric molecules E. Omelina1*, A. Ivankin1, A. Leshchenko1,2, L. Yarinich1, M. Lebedev1,2, A. Pindyurin1 1 Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia GTB23 Tandem repeats in mammalian genomes D. Ostromyshenskii1*, O. Podgornaya1, 2 1 Institute of Cytology RAS, Saint Petersburg, Russia; 2 Saint Petersburg State University, Saint Petersburg, Russia GTB24 Electrostatic up-element and promoter strength A. Osypov1 2*, G. Krutinin3, E. Krutinina3, P. Beskaravayny3, S. Kamzolova3 1 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 2 Institute of Theoretical and Experimental Biophysics RAS, Pushchino MR, Russia; 3 Institute of Cell Biophysics RAS, Pushchino MR, Russia GTB25 Selecting codons not for proteins: Codons and amino acids biases around proteins binding DNA sites are due to their electrostatics A. Osypov1 2*, G. Krutinin3, E. Krutinina3, P. Beskaravayny3, S. Kamzolova3 1 Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; 2 Institute of Theoretical and Experimental Biophysics RAS, Pushchino MR, Russia; 3 Institute of Cell Biophysics RAS, Pushchino MR, Russia GTB26 Transcriptomic comparative analysis of hippocampal tissue and primary cultures after hyaluronidase treatment V. Pershin1,2*, A. Balashova2, E. Guryev1,2, L. Kurbatov3, M. Gainullin1,4, I. Mukhina1,2 1 Privolzhsky Research Medical University, Nizhny Novgorod, Russia; 2 Lobachevsky State University, Nizhny Novgorod, Russia; 3 Orekhovich Institute of Biomedical chemistry, Russian Academy of Medical Sciences, Moscow, Russia; 4Oslo University Hospital, Oslo, Norway GTB27 Identification of 3 unknown bacterial strains, characterization of Copper Oxidase Genes M. Plotnikova1 1 Voronezh State University, Department of Genetics, Cytology and Bioengineering, Voronezh, Russia GTB28 Potential biomarkers associated with poor prognosis for local-ly advanced prostate cancer without lymphatic dissemination E. Pudova*1, E. Lukyanova1, K. Nyushko2, S. Kharitonov1, A. Snezhkina1, M. Fedorova1, A. Kaprin2, B. Alekseev2, A. Kudryavtseva1,2 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.; 2 National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia GTB29 Graph-oriented database for analysis of prokaryotic communities -omics data A. Ryasik*1, T. Ermak1,2, M. Orlov1, E. Zykova1, A. Sorokin1 1. Institute of Cell Biophysics RAS, Pushchino, Russia; 2. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia GTB30 Genomic reconstruction of histidine metabolism and regulation in human microbiome N.V. Sernova, I.A. Zharov, G.A. Ashniev, S.A. Leyn, D.A. Rodionov * Institute for Information Transmission Problems RAS GTB31 Identification of an ABC-type multidrug efflux pump MacAB genes in the genome of Serratia marcescens SM6. T.V. Shirshikova1*, D.S. Pudova1, D. A. Kabanov1, A. O. Tikhonova1, M.R. Sharipova1, L.M. Bogomolnaya1, 2 1 Kazan (Volga region) Federal University, Kazan, Russia; 2 Texas A&M University Health Science Center, Microbial Pathogenesis and Immunology, Bryan, USA GTB32 Metastatic prostate cancer cells in lymph nodes perturb nodal laminin expression M. Shkurnikov1*, D. Maltseva1 1 National Medical Research Radiology Center, Obninsk, Russia

GTB33 Artificial Intelligence in the Problems of Analysis and Interpretation of Omics Human Data A. Shlikht1*, N. Kramorenko1 1 Far Eastern Federal University, Vladivostok, Russia GTB34 MYH3 is a novel gene associated with carotid paragangliomas A. Snezhkina1*, E. Lukyanova1, D. Kalinin2, E. Pudova1, M. Fedorova1, S. Kharitonov1, Z. Guvatova1, I. Abramov1, G. Krasnov1, N. Melnikova1, A. Dmitriev1, A. Kudryavtseva1,3 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2Vishnevsky Institute of Surgery, Ministry of Health of the Russian Federation, Moscow, Russia; 3National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia GTB35 Hsp as a long-term buffer of the genome-wide mutation burden A.Sokol1* , K. Ushakova1, A. A. Mikhaylova1, A. G. Mikhaylova1 D. Knorre3, I. Mazunin1, A. Reymond5, K. Gunbin1,4, K. Popadin1,5 1The School of Life Sciences, Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation; 2Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; 3The A.N. Belozersky Institute Of Physico-Chemical Biology, MSU, Moscow, Russian Federation; 4The Institute of Cytology and Genetics of the SB RAS, Novosibirsk, Russian Federation; 5Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland GTB36 BRCA mutation and castration-resistant prostate cancer, association with the AKT / m-TOR signaling cascade L.V.Spirina 1,2*, A.K. Gorbunov 1, E.A. Usynin 1, E.M. Slonimskaya 1,2, I.V. Kondakova 1 1 Cancer Research Institute, TNIMC, Tomsk;2 Siberian State Medical University, Tomsk GTB37 The interplay of Piwi and heterochromatin proteins in transposable element silencing in the germline of Drosophila melanogaster A. Stolyarenko 1*, T. Leinsoo 1, Y. Abramov 1, P. Mazin 2, M. Klenov1 1 Institute of Molecular Genetics RAS, Moscow, Russia; 2 Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, Moscow, Russia GTB38 Comparative Transcriptomics of the Moss Physcomitrella patens under biotic stress N. Sukhikh1, E. Egorova1, A. Predeus2, S. Vinogradova1* 1 Institute of Bioengineering, Research Centre of Biotechnology RAS, Moscow, Russia 2 Bioinformatics institute, Saint Petersburg, Russia GTB39 The use of a horizontally scalable infrastructure in the search for genetic similarity in biodiversity A.Tskhai1,2*,S.Murzintsev3 1 Institute for Water and Environmental Sciences SB RAS, Barnaul, Russia;2 Altai State Technical University named Polzunov I. I., Barnaul, Russia;3 Altai State University, Barnaul, Russia GTB40 MiRNA seed shifting: origin and functional implications P. Vorozheykin1*, N. Yazikov1, I. Titov1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia GTB41 Improvement of a Test-system for Detecting Inherited and Non-inherited Genetic Changes in Living Cells A. Zhuk1, 2*, E. Stepchenkova 1, 2, S. Inge-Vechtomov1, 2 1 Saint-Petersburg State University, Saint-Petersburg, Russia; 2 Saint-Petersburg Branch of Vavilov Institute of General Genetics, Saint- Petersburg, Russia GTB42 DNA sequence features that may establish H3K27Ac mark Anatoliy Zubritskiy*1, Yulia A. Medvedeva1-3 1 Institute of Bioengineering, Research Centre of Biotechnology, Russian Academy of Sciences, Moscow, 119071, Russian Federation; 2 Department of System Biology and Bioinformatics, Vavilov institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russian Federation; 3 Department of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russian Federation

POSTER SESSIONS Poster Session 1. Genetics and Molecular Biology Tuesday, 21 August

Med.1.1. Association rs189037 in the ATM Gene with Bronchial Asthma Taking into Account Environmental Factors. N. Babushkina*, A. Postrigan, A. Kucher. Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk, Russia Med.1.2. Model Melanocortin Obesity: Immunohistochemical Examination of Cyclooxygenase- 2 and Macrophages in the Kidney of Ay Mice. N.V. Baginskaya*, N.S. Logvinenko. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.3. IL4 (rs 2243250) Gene Polymorphism Depending on the Clinical Features Psoriatic Disease. A. Barilo*, S. Smirnova, M. Smolnikova. Scientific Research Institute of Medical Problems of the North, Federal Research Center «Krasnoyarsk Science Center» of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia Med.1.4. A Search for Molecular Relationships Between Bronchial Asthma and Hypertension as an Example of Comorbid Diseases. E.Yu. Bragina1, M.B. Freidin1, I.A. Goncharova1, O.V.Saik2, O.I. Zolotareva3, V.A. Ivanisenko2, V.E. Dosenko4, R. Hofestaedt3. 1Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia; 2The Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; 3Bielefeld University, Bielefeld, Germany; 4Bogomoletz Institute of Physiology, National Academy of Science, Kiev, Ukraine Med.1.5. Genome Rearrangements in Bacterial Genomes. O.O. Bochkareva, M.S. Gelfand4. 1Institute of Information Transmission Problem RAS, Moscow, Russia; 2Lomonosov State University, Moscow, Russia;3Higher School of Economics, Moscow, Russia; 4Skolkovo Institute of Science and Technology, Moscow, Russia Med.1.6. Computer Method for Image Enhancement in Fish Diagnostics. A.G. Bogomolov1,2*, T.V. Karamysheva2, N.B. Rubtsov1,2. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.1.7. Fluctuating asymmetry of gene expression in embryos derived by in vitro fertilization. N.A. Feofanova1*, G.V. Kontsevaya2, M.V. Anisimova2, Y.L. Gon3, Y.M. Moshkin2. 1Institute of Clinical Immunology SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.1.8. Alternative Splicing in Transcriptomes of Glioma Cell Cultures. N.V. Gubanova1*, V.N. Babenko S.S. Kovalev A.V. Tsukanov A.O. Bragin Y.L. Orlov2. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia; 3Novosibirsk State Medical University, Novosibirsk, Russia Med.1.9. Molecular-Genetic Phenotype of Experimental Breast Cancer. A.V. Kabakov*, A.P. Lykov, D.V. Morozov, O.V. Kazakov, A.F. Poveshchenko, T.V. Rayter, D.N. Strunkin, V.I. Konenkov. Research Institute of Clinical and Experimental Lymphology – branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.10. The Relationship of the Genes Expression of Actin-Binding Proteins with Metastasis in Squamous Cell Carcinoma of the Head and Neck and Non-Small Cell Lung Cancer. G. Kakurina1*, E. Kolegova, I. Kondakova1, A. Dobrodeev, D. Kostromitsky, О. Cheremisina1, Е.L. Choynzonov1,2. 1Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia; 2Siberian State Medical University, Tomsk, Russia Med.1.11. Search for a Signals of Genetic Adaptation to High-Mountain Living in Populations of Dagestan. V. Kharkov1*, A. Zarubin1, K. Vagaitseva1, M. Radzhabov2, V. Stepanov1. 1Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics, Tomsk, Russia; 2Daghestan Institute of Physics after Amirkhanov, Makhachkala, Russia Med.1.12. Generation of 293FT Cell Lines Deficient in Base Excision Repair and Mismatch Repair by CRISPR/Cas9-Mediated Genome Editing. D. Kim1,2*, L. Kulishova1, N. Torgasheva1, D. Zharkov1,2. 1Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.1.13. Adaptive Strategies of Motile Bacteria in Dynamic Aquatic Ecosystems. A Simulation Study. A.I. Klimenko*, Yu.G. Matushkin, S.A. Lashin. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia Med.1.14. Maturity-Onset Diabetes of the Young Due to HNF1B Mutation: a Case Report. V.V. Klimontov1*, D.M. Bulumbaeva1, E.A. Koroleva1, A.K. Ovsyannikova2, O.D. Rymar2, D.E. Ivanoshchuk2, E.V. Shakhtshneider2. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Research Institute of Therapy and Preventive Medicine – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.15. Comparative Analysis of Protein-Coding Potential of mRNAs and lncRNAs Based on Sequence Features. Yu. Kondrakhin1,2, R. Sharipov2,3, O. Volkova4*. 1Institute of Computational Technologies SB RAS, Novosibirsk, Russia; 2BIOSOFT.RU, Ltd, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia; 4Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.16. An Integrative Framework for Effective Identification of Functional Disease- Associated Variants in Genome-Wide Studies. E. Korbolina1, 2 *, L. Bryzgalov1, A. Degtyareva1, M. Verstunina3, T. Merkulova1, 2. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia; 3Novosibirsk State Medical University, Novosibirsk, Russia Med.1.17. Computer Analysis of Transcriptomes in Glioma Cells. S.S. Kovalev, N.V. Gubanova, A.V. Tsukanov, A.O. Bragin, Y.L. Orlov3. 1Novosibirsk State Medical University, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.1.18. ADRB1 Gene Polymorphism and Pro-arrhythmic Electrocardiographic Patterns in the General Population of Novosibirsk. A.A. Kuznetsov*, A.A. Kuznetsova, T.I. Batluk, V.N. Maksimov, M.I. Voevoda, S.K. Malyutina, Yu.P. Nikitin. Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.19. Use of Next-Generation Sequencing (NGS) to Clarify the Cause of a Premature Newborn Death: Clinical Case. A. Mikhalenka1*, M. Artsiusheuskaya2, O. Malyshava1, A.Shchayuk1, S.Kachan3, G. Kulakova2, A. Kilchevsky1. 1Institute of Genetics and Cytology of NASB, Minsk, Belarus; 2Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus; 3Clinical maternity hospital of Minsk region, Minsk, Belarus Med.1.20. Novel Lentiviral Vectors for Studies of Glioblastoma. O. Mozhei1*, A.G. Teschemacher2, S. Kasparov2. 1Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 2Bristol University, Bristol, UK Med.1.21. Application of New Bioinformatics Approach for Prediction of Metabolic Capabilities for Carbohydrate Fermentation in Human Gut Microbiome. A.A. Murtazin*, A.A. Arzamasov, S.N. Yablokov, D.A. Rodionov. Institute for Information Transmission Problems RAS Med.1.22. Application of Plant ROS1 5-Methylcytosine-DNA Glycosylase as Tool for Directed Epigenetic Demethylation in Human Cells. D. Petrova1*, I. Grin1, 2, D. Zharkov1,2. 1Institute of Chemical biology and fundamental medicine SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.1.23. Genetic Adaptation of Human Populations to Climatic Conditions of Northern Eurasia. A. Popovich*, V. Stepanov, K. Vagaitseva, A. Bocharova. Research Institute of Medical Genetics, Tomsk National Research Medical Center of RAS, Tomsk, Russia Med.1.24. Polymorphic Variants of Signaling Pathway Akt1/GSK-3β Gene and Tardive Dyskinesia in Schizophrenic Patients. Ivan V. Pozhidaev1, Anastasia Levchenko3 , Diana Z. Osmanova1, Innokentiy S. Losenkov1, Olga Yu. Fedorenko1, Natalya M. Vyalova1, Аrkady V. Semke1, Bob Wilffert2, Anton J.M. Loonen2, Svetlana A. Ivanova1. 1Mental Health Research Institute, Tomsk National Research Medical Center of RAS, Tomsk, Russia; 2Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands; 3Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia Med.1.25. Interactome Network Topology in Diabetic Retinopathy. V. Prokof`ev1*, A. Shevchenko1, V. Konenkov1, V. Klimontov1. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.26. Study of mtDNA Copy Number and LINE-1 in Atherosclerosis. R. Salakhov1*, M. Golubenko1,2, A. Markov1, A. Sleptcov1, M. Nazarenko1,2, O. Barbarash2, V. Puzyrev1. 1Research Institute of Medical Genetics, Tomsk National Research Medical Center RAS, Tomsk, Russia; 2Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia Med.1.27. Exome Analysis of Patients with Maturity onset Diabetes of the Young in Russia. E. Shakhtshneider1,3*, D.E. Ivanoshchuk1,2,3, A.K. Ovsyannikova1, O.D. Rymar1, M.I. Voevoda1, 2,3.1Research Institute of Internal and Preventive Medicine – branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.1.28. Association of Intracellular Proteolytic Systems and Locomotor Proteins in Tissues of Primary Tumor and Lymphogenous Metastases of Breast Cancer. Е. Shashova, N. Tarabanovskaya, E. Slonimskaya, I. Kondakova. Tomsk National Research Medical Center of RAS, Tomsk, Russia Med.1.29. Orthopoxviral TNF-binding Protein. S.N. Shchelkunov1,2*, T.V. Tregubchak1, I.P. Gileva1. 1State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk region, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.30. Polymorphism of Genes of Endothelial Dysfunction, Mitochondrial Biogenesis Coactivators and Plasminogen-Plasmin System in Development of Cardiovascular Complications in Rheumatoid Arthritis. A. Shevchenko1*, V. Prokof'ev1, M. Korolev1, V. Omelchenko1, V. Konenkov1. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.1.31. Identification of an ABC-Type Multidrug Efflux Pump MacAB Genes in the Genome of Serratia Marcescens SM6. T.V. Shirshikova, D.S. Pudova, D. A. Kabanov, A. O. Tikhonova, M.R. Sharipova, L.M. Bogomolnaya2. 1Kazan (Volga region) Federal University, Kazan, Russia; 2Texas A&M University Health Science Center, Microbial Pathogenesis and Immunology, Bryan, USA Med.1.32. Role of DNA Methylation in Incomplete Penetrance of Copy Number Variations. N.A. Skryabin1*, S.A. Vasilyev1, E.N. Tolmacheva1, R.R. Savchenko1, D.I. Zhigalina1, A.A. Kashevarova1, A.A. Zarubin1, E.O. Belyaeva1, L.P. Nazarenko1, I.N. Lebedev1. 1 Research Institute of Medical Genetics TNRMC, Tomsk, Russia Med.1.33. Copy Number Calling from Infinium Methylation EPIC Array in Human Carotid Atherosclerotic Plaques. A.A. Sleptsov1*, M.S. Nazarenko1,2,3, A.V. Markov1, D.V. Sharysh3, A.N. Kazantsev2, O.L. Barbarash2, V.P. Puzyrev1,3. 1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia; 2Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia; 3Siberian State Medical University, Tomsk, Russia Med.1.34. Circulating Adiponectin Concentrations are Sex-Dependently Associated with Specific SNPs of ADIPOQ and LEP Genes. S. Smetnev, M. Klimushina*, A. Meshkov, N. Gumanova, N. Gavrilova, A. Ershova, A. Kiseleva, V. Metelskaya. National Medical Research Center for Preventive Medicine, Moscow, Russia Med.1.35. Carnitine Palmitoyltransferase1A (CPT1A) P479L Allele Prevalence in the Arctic Native Populations of East Siberia. M. Smolnikova, S. Tereshchenko. Scientific Research Institute of Medical Problems of the North, Federal Research Center «Krasnoyarsk Science Center» SB RAS, Krasnoyarsk, Russia Med.1.36. Genes of Cytokines in Controlled and Uncontrolled Asthma in Children (East Siberia). M. Smolnikova*, S. Smirnova, O. Konopleva. Scientific Research Institute of Medical Problems of the North, Federal Research Center «Krasnoyarsk Science Center» SB RAS, Krasnoyarsk, Russia Med.1.37. Metabolic Syndrome Associated FTO Gene Polymorphism in Populations of Buryats and Russians of Eastern Siberia. L.E. Tabikhanova1*, L.P. Osipova1,3, E.N. Voronina2,3, M.L. Filipenko2,3. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.1.38. Role of the Dominant Placental Protein Pregnancy Specific β-1-Glycoprotein in the Regulation of T-Cell Immune Memory. Timganova V.P.1*, Litvinova L.S.2, Yurova K.A.2 , Khaziakhmatova O.G.2, Bochkova M.S.1 , Khramtsov P.V.1, Rayev M.B. 1, Zamorina S.A. 1. 1Institute of Ecology and Genetics of Microorganisms UB RAS, Perm; 2Immanuel Kant Baltic Federal University, Kaliningrad Med.1.39. The Interaction Effect of Angiogenesis and Endothelial Dysfunction-Related Gene Variants Increases the Susceptibility of Recurrent Pregnancy Loss. E. Trifonova1, 2*, O. Ganzha2, V. Serebrova1, T. Gabidulina2, V. Stepanov1. 1Research Institute of Medical Genetics SB RAMS, Tomsk, Russia; 2Siberian State Medical University, Tomsk, Russia Med.1.40. Variability in Gibbs Energy of tRNA Molecules in Mitochondrial Genomes of Chordates: Neutral Selection or Evolution Towards Optimization of Translation? K. Ushakova1*, A. A. Mikhaylova1, A. G. Mikhaylova1, D. Knorre3, I. Mazunin1, A. Reymond5, K. Gunbin1,4, K. Popadin1,5**. 1The School of Life Sciences, Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 2Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK; 3The A.N. Belozersky Institute Of Physico-Chemical Biology, MSU, Moscow, Russia; 4The Institute of Cytology and Genetics of the SB RAS, Novosibirsk, Russia; 5Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland Med.1.41. Weighted Interaction SNP Network for Samples of Individuals with High and Low Cognitive Abilities. K. Vagaytseva1*, A. Zarubin1, O. Makeeva1, V. Stepanov1. Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russia Med.1.42. Drug re-targeting as alternative approach for the treatment of glioma A. Vasilev 1 *, S. Kasparov 2 1Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 2 Bristol University, Bristol, UK Med.1.43. Features of Spontaneous and Induced Mutagenesis in Somatic Cells Depends on DNA Repair Foci. S.A. Vasilyev1*, R.R. Savchenko1, A.A. Murashkina2, V.S. Fishman3, E.V. Sukhikh4, Lebedev I.N.1. 1Research Institute of Medical Genetics TNRMC, Tomsk, Russia; 2Tomsk State University, Tomsk, Russia; 3Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 4Tomsk Regional Oncology Center, Tomsk, Russia Med.1.44. Mechanisms of Inactivation of the TP53 Gene in Diffuse Large B-Сell Lymphoma. Voropaeva E.N.1,2*, Pospelovа T.I.2, Voеvodа M.I.1 Maksimov V.N.1, O.B.2. 1Research Institute of Therapy and Preventive Medicine – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State Medical University, Novosibirsk, Russia Med.1.45. Exome-Wide Search and Functional Annotation of Genes Associated with Severe Forms of Tick-Borne Encephalitis in Russians. N. S.Yudin1,2*, A.A. Yurchenko1, M.I. Voevoda1,2, E.V. Ignatieva 1,2. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.1.46. qGEPS: the Tool for Relative Quantification of Gene Expression in Paired Samples. A. Zyablitsin1, N. Melnikova1, G. Krasnov1, A. Dmitriev1*. 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia Med.1.47. A Synonymous Variant in GCK Gene as a Cause of Gestational Diabetes Mellitus. N. Zubkova1*, P. Rubtsov2, L. Ibragimova1, E. Vasiliev1, V. Petrov1, A. Tiulpakov1. 1Endocrinology Research Centre, Moscow, Russia; 2Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, Russia Med.1.48. Clinical case: rare mutations in the CYP1B1 gene in a patient with primary congenital glaucoma Fishman1, O. Fenkova2, M.Voevoda1,3,4, A.Fursova2, D. Ivanoshchuk1,2,4*. 1 Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State Regional Clinical Hospital, Novosibirsk, Russia; 3 Research Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, Novosibirsk, Russia; 4 Novosibirsk State University, Novosibirsk, Russia

Poster Session 2. Biomedicine, Pharmacology and Clinical Medicine Wednesday, 22 August

Med.2.1. Design of Vaccine Constructs Capable of Inducing a Cross Protective Effect Against Different Strains of the Influenza Virus A. S. Bazhan*, D. Antonets, L. Karpenko, T. Ilyicheva, O. Kaplina, V. Marchenko, S. Oreshkova. State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk region, Russia Med.2.2. Ultrastructutal Organization of Hepatocytes in Distant Tumor Growth. S. Bakhbaeva*, N. Bgatova, Yu. Taskaeva, V. Makarova, Yu. Borodin. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.3. Regenerative Technologies in the Treatment of Knee Osteoarthritis. N. Banshсhikova1*, V. Omelchenko1, E. Letjagina1, A. Akimova1, O. Poveshchenko1, A. Lykov 1, M. Surovtseva1, A. Evsyukov1, A. Yezhov1, A. Zobnin1, M. Korolev1. 1Institute of Clinical and Experimental Lymphology – branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.4. Neuroprotective Effects of Lithium Carbonate in Conditions of Tumor Growth. N.Bgatova1*, Yi.Taskaeva1, V.Makarova1, O.Solovjeva2, N.Khotskin2, A.Docenko2, E.Zav,yalov2, S.Shatskaya3, V.Isupov3,Yu.Borodin1. 1Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russia Med.2.5. Modified Sorbents for Pharmacology. Yu.I. Borodin, L.N. Rachkovskaya*, T.V. Popova, А.А. Kotlyarova, S.V. Michurina, A.V. Shurlygina, E.E. Rachkovsky, M.V. Robinson, P.G. Madonov, M.A. Korolev, A.Yu. Letyagin, V.I. Konenkov. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Med.2.6. Serum Levels of Adipokines in Type 2 Diabetic Subjects: the Relationships with Adipose Tissue Distribution and Microvasculature. D.M. Bulumbaeva 1*, N.P. Bgatova1, Yu.S. Taskaeva1, O.N. Fazullina1, N.B. Orlov1, V.I. Konenkov1, S.V. Savchenko2. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; 2Novosibirsk State Medical University, Novosibirsk, Russia Med.2.7. Characterization of Cell Division in Primary Hippocampal Cultures Derived from Kaiso Deficient Mice. N. B. Illarionova1*, E.Y. Bazhenova1, D.V. Fursenko1, N.V. Khotskin1, I.E. Sorokin1, A.V. Kulikov1. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.8. Evaluation of circulating tumor cells with epithelial-mesenchymal transition properties in the blood of breast cancer patients with different effect of neoadjuvant chemotherapy. E. Kaigorodova1, 2*, V.Perelmuter 1, N. Tarabanovskaya1, E. Simolina1, E. Choynzonov1,2. 1Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia; 2 Siberian State Medical University, Tomsk, Russia Med.2.9. Structure of Regional and Remote Lymph Nodes at Treatment of Chemically Induced Breast Cancer Using Double-Stranded DNA Human Panagen. O. V. Kazakov1*, A.V. Kabakov 1, A.F. Poveshchenko1, T.V. Reiter1, D.N. Strunkin1, S.S. Bogachev2, A.P. Lykov 1, V.I. Konenkov 1. 1Research Institute of Clinical and Experimental Lymphology – branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.10. Technologies of Blood Saving with the Use of Tranexamic Acid in Myomectomy. D. Khabarov, M. Kochetkova, I. Siutkina, F. Rakitin, P. Bulychev. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.11. New Indicator for Edema Evaluation. R. Khapaev*, V. Nimaev, O. Shumkov, M. Soluyanov, M. Smagin. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Russia Med.2.12. Switching to Insulin Glargine 300 U/Ml from Other Basal Insulin Analogues Provides Less 24-Hour Glucose Variability in Hospitalized Patients with Type 1 Diabetes. V.V. Klimontov1*, E.A. Koroleva, O.N. Fazullina. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.13. Empagliflozin and Linagliptin Demonstrate Antifibrogenic Activity in db/db Mice, a Model of Type 2 Diabetes. A.I. Korbut1*, V.V. Klimontov1, Yu.S. Taskaeva1, N.P. Bgatova1, A.D. Dozenco2, E.L. Zavyalov2. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.14. Comparative Pharmacokinetic Analysis of а Novel Prolonged Release Dosage form of Lithium Citrate in Mice. A. A. Kotlyarovа1,2*, A. Yu. Letyagin1, T.G Tolstikova2, L. N. Rachkovskaya1. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2N.N. Vorozhtsov Institute of Organic Chemistry SB RAS, Novosibirsk, Russia Med.2.15. Pathogenesis of Cerebral Cortex Damage in Mice During Infection with Seasonal Influenza A Virus. A.Kovner1*, P.Kozhin1, O. Kurskaya1, A. Slepneva2. 1Research Institute of Experimental and Clinical Medicine – subdivision of FRC FTM, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.2.16. Ultrasound Technologies for Quantitative Characterization of Insulin-Induced Lipohypertrophy in Subjects with Diabetes. M.M. Lazarev*, A.A. Makhotin, V.V. Klimontov, D.M. Bulumbaeva, E.A. Koroleva, A.Y. Letyagin. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.17. Simulation of Circadian Temporal Organization of the Lymph Node System Using the Automated Expert Program SMLN. A.Yu. Letyagin, A.V. Shurlygina*, I.B. Belan, M.V. Robinson, V.A. Trufakin. Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, SB RAS Novosibirsk, Russia Med.2.18. Autologous Plasma Enriched with Platelet Lysate for Treatment in Patients with Age- Related Macular Degeneration. A.P. Lykov1,2, O.V. Poveshchenko1,2, M.A. Surovtseva1,2, O.M. Stanishevskaya3, D.V. Chernykh3, N.S. Arben’eva3, V.I. Bratko3. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Research Institute of Circulation Pathology, Ministry of Health Care of Russian Federation, Novosibirsk, Russia; 3S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Russia Med.2.19. Bone Marrow Hematopoiesis and Peripheral Blood Parameters in Mice with Chronic Opisthorchiasis and Social Stress. M. Lvova1*, I. Orlovskaya2, L. Toporkova2, I. Sorokina3, D. Avgustinovich1. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia; 3N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, Russia Med.2.20. Apoptosis in the liver of DB/DB Mice Female in Postnatal Ontogenesis. S. V. Michurina1, I.Yu.Ishchenko1, M.A.Cherepanova1, S.A. Arkhipov1, E.L. Zavjalov2 (D.V. Vasendin3). 1Institute of Clinical and Experimental Lymphology – a branch of The Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State Medical University, Russia Med.2.21. Linagliptin Effect on the Relation of Apoptosis Regulators Bcl-2 and Bad in DB/DB Mice Liver. S. V. Michurina1*, I. Yu. Ishchenko1, M. A. Cherepanova1, S. A. Arkhipov1, V. V. Klimontov1, E. L. Zavjalov2. 1Research Institute of Clinical and Experimental Lymphology - branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.22. Glucose Variability in Type 1 Diabetic Patients with Different Stages of Chronic Kidney Disease. N. E. Myakina1*, A.K. Vigel2, I.Y. Lots3. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Regional Clinical Hospital, Barnaul, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.2.23. Continuous Glucose Monitoring Data Analysis in Insulin-Treated Type 1 And Type 2 Diabetic Subjects with the Use of Original Software. N.E. Myakina, I.Y. Lots, V.V. Klimontov2. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.2.24. Heterogeneity of Motility of Chondrocyte Population from Minipig’s Knee-Joint. S. V. Nikolaev1*, U. S. Zubairova1, K. E. Orishchenko1, N. M. Astakhova2, A. A. Voropaeva2, E. I. Shchelkunova2, and I. A. Kirilova2. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Ya. L. Tsivyan Novosibirsk Research Institute of Traumatology and Orthopedics, Novosibirsk, Russia Med.2.25. Detection of the Lymphatic Capillaries in the Optic Nerve Sheath. S. Nogovitsina*1, N. Bgatova1, Yu. Borodin1, V. Chernykh2, A. Trunov2, A. Eremina2, V. Konenkov1. 1Reseach Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia; 2The academician S.N. Fyodorov Federal State Institution «Intersectoral Research and Technology Complex «Eye Microsurgery», Ministry of Healthcare of Russian Federation, Novosibirsk Branch, Novosibirsk, Russia Med.2.26. Regeneration of Rat Skeletal Muscle Induced by MSC-Populated Collagenous Scaffolds. А. Novokreshchenova1*, N. Butorina1, O. Payushina1, O. Sheveleva1, E. Domaratskaya1. Koltzov Institute of Developmental Biology of RAS, Russia Med.2.27. MicroRNA in Lymph in Experimental Breast Cancer. A.F. Poveshchenko*, A.V. Kabakov, A.P. Lykov, O.V. Kazakov, T.V. Rayter, D.N. Strunkin, V. I. Konenkov. Research Institute of Clinical and Experimental Lymphology – branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.28. Effect of Cytokines on Functional Properties of Fibroblasts. O.V. Poveshchenko*, A.P. Lykov, M.A. Surovtseva, N.A. Bondarenko, I.I. Kim, V.I. Konenkov. Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.29. Natural Bispecific Antibodies: Generation, Isolation, Biological Functions. S. E. Sedykh1,2*, V.V. Printz1, 2, V.N. Buneva1,2, G.A. Nevinsky1,2. 1Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Med.2.30. Radiofrequency Ablation of Varicose Veins in Obese Patients. O. Shumkov1, M. Smagin1, V. Nimaev1*, M. Soluyanov1, A. Sadovskii2. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Multidisciplinary clinic «Medsanchast-168», Novosibirsk, Russia Med.2.31. PRP in Treatment of Non-Healing Ulcers. M. Smagin*, A.Demura, O. Shumkov, T.Isaeva1.2, M. Soluyanov, O. Poveshenko, V.V. Nimaev. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University. Novosibirsk, Russia Med.2.32. Platelet-Rich Plasma Coated PCL Nanofibers Boost Viability and Proliferation of Human Mesenchymal Stem Cells. A. O. Solovieva1*, S.M. Miroshnichenko1,2, T.N. Pozmogova1, A.M. Manakhov3. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2FRC of FTM - Institute of Biochemistry, Novosibirsk, Russia; 3National University of Science and Technology “MISiS”, Moscow, Russia Med.2.33. Personalization Treatment of the Bladder Leukoplakia. M.Yu. Soluyanov*, M.A. Smagin, O.A. Shumkov, V.V. Nimaev. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.34. Effectiveness of Cytocine Antihypoxic Cerebroproteciton. E. Suprun*, S. Tereshchenko, S. Tronko, E. Kachalova. National Pharmaceutical University, Clinical Pharmacology, Kharkov, Ukraine Med.2.35. Oxidative Stress Protection of the Bone Marrow-Derived Mesenchymal Stem Cells by Erythropoietin. M.A. Surovtseva,* I.I., Kim, A.P. Lykov, N.A. Bondarenko, O.V. Poveshchenko. Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.36. A Search for Potential Anthelminthic Drugs Using the Model of Opisthorchis felineus- Induced Opisthorchiasis. Tsyganov1*, G. Vishnivetskaya1, A. Kovner1, I. Sorokina2, A. Dushkin3, V. Mordvinov1, D. Avgustinovich1. 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS, Novosibirsk, Russia; 3Institute of Solid State Chemistry and Mechanochemistry SB RAS, Novosibirsk, Russia Med.2.37. Analysis of Clinical Forms of Leg Lymphedema. Single-Center Experience. D. Usmonov3, O. Saik2, 3, V.Nimaev1,3*. 1Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Novosibirsk State University, Novosibirsk, Russia Med.2.38. Synthesis of caged NO and epinephrine compounds for optically controlled platelets activation. A. Yu. Vorob’ev1,2, O. Yu. Karmatskih1, D. V. Spiryova1, A.Е. Moskalensky1,3. 1Novosibirsk State University, Novosibirsk, Russia; 2N.N. Voroztsov Institute of Organic Chemistry, Novosibirsk, Russia; 3Voevodsky Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia Med.2.39. Bone Mineral Density Changes in Patients with Hodgkin's Lymphoma. M. Voytko1*, T. Pospelova1, V. Klimontov2, O. Fazullina2. 1Novosibirsk State Medical University, Novosibirsk, Russia; 2Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Med.2.40. Hypovitaminosis D as a Biomarker of Cardiovascular Risk in Patients with Rheumatoid Arthritis. A. Zazdravnov. Kharkiv National Medical University, Kharkiv, Ukraine Med.2.41. Morphology and Proteomic Analysis of Human Placental Exosomes. E. Burkova1*, G. Nevinsky1,2. 1Institute of Chemical biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Med.2.42. Hepatoprotective effect of various antioxidants in the pathogenesis of opisthorchiasis O. Zaparina1*, A. Kovner1, A. Rakhmetova2, M.Pakharukova1,2, V. Mordvinov1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia

SECTION: «Bioinformatics and systems biology of plants» 22 August, Wednesday

Plant1 Using the mathematical modeling approach to access the behavior of plant antioxidant system under abiotic stress conditions A. Bobrovskikh1,2*, A. Doroshkov1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant2 Genome-scale metabolic model predicts carbon flux partitioning towards starch biosynthesis in storage root of cassava P. Chiewchankaset1, W. Siriwat2, S. Kalapanulak2,3, T. Saithong2,3 1 Division of Biotechnology, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi (Bang Khun Thian), Bangkok, Thailand; 2 Systems Biology and Bioinformatics Research Group, Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi (Bang Khun Thian), Bangkok, Thailand; 3 Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi (Bang Khun Thian), Bangkok,, Thailand Plant3 Design of genetic sensors to ethylene based on bioinformatics analysis of whole-genome data V. Dolgikh Novosibirsk State University, Novosibirsk, Russia Plant4 Molecular evolution analysis of genetic network components related to plant trichome development A.V. Doroshkov1,2, D.K. Konstantinov1, K. V. Gunbin1,2 and D. A. Afonnikov 1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant5 Digital collection of morphological variability of wheat spike M.Genaev1, E.Komyshev1, Fu Hao2,3, V.Koval1, N.Goncharov1,4, D.Afonnikov1,2 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk StateUniversity, Novosibirsk, Russia; 3 Heilongjiang University, Harbin, China; 4 Novosibirsk State Agrarian University, Novosibirsk, Russia Plant6 Organization and evolution chalcone synthase gene family in bread wheat and related species A. Yu. Glagoleva1,2, E.K. Khlestkina1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant7 Genetic variability of tea plant (Camellia sinensis (L.) Kuntze) on the Black Sea coast of Caucasus Gvasaliya M.V.1, Samarina L.S.*1, Orlov Yu.L.2, Hanke M.-V.3, Flachowsky H.3 1FSBSI Russian Research Institute of Floriculture and Subtropical Crops, Sochi, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3 Julius Kühn-Institut (JKI), Federal Research Institute for Cultivated Plants Institute for Breeding Research on Fruit Crops, Dresden, Germany Plant8 Resistivity estimation for a row of potato starches of domestic collection L. Gvozdeva, V. Khlestkin Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Plant9 Genome-wide prediction of transcription factor binding sites in cassava via phylogenetic footprinting between plants in Euphorbiaceae family S. Kalapanulak1,2, C. Rangsiwutisak3, T. Saithong1,2 1 Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bang Khun Thian, Bangkok, Thailand; 2 Systems Biology and Bioinformatics Research Laboratory, Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bang Khun Thian, Bangkok, Thailand; 3 Bioinformatics and Systems Biology Program, School of Bioresources and Technology, and School of Information Technology, King Mongkut’s University of Technology Thonburi, Bang Khun Thian, Bangkok, Thailand Plant10 Database on Molecular Identification of Genes for Resistance in Wheat (MIGREW) 1,2 1 1 1,2 F.V. Kazantsev , E.S. Skolotneva , E.A. Salina , S.A. Lashin 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant11 The First Study of Genetically Regulated Potato Starch Bio-chemical Characteristics for S. tuberosum Cultivars of Russian Selection V. Khlestkin1,2*, T. Erst1, L. Gvozdeva1, Yu. Khoroshavin1,2, I Totsky1, Е. Khlestkinа1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant12 The synthesis of antioxidant enzymes in potato plants under biotic and abiotic stress conditions I. Kirgizova1*, A. Gajimuradova2, R. Omarov2 1Omsk State Technical University, Omsk, Russia; 2L.N.Gumilyov Eurasian National University, Astana, Kazakhstan Plant13 Impact of DNA reorganization on recombination suppression of 5b chromosome during wheat evolution. A.A. Kiseleva1*, A.F. Muterko1, Z. Frenkel2, A. Korol2, E.A. Salina1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Evolution, University of Haifa, Haifa, Israel Plant14 Wheat Ear Recognizing Algorithm For High Throughput Wheat Phenotyping E.Komyshev1*, M.Genaev1, S.Tumanyan1, N.Goncharov1,3, D.Afonnikov1,2, V.Koval1 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia; 3Novosibirsk State Agrarian University, Novosibirsk, Russia Plant15 MetaRE: search for cis-regulatory elements via meta-analysis of transcriptomic data Novikova D.D.1,2,3, Cherenkov P.A.1, Tkachev K.U.2, Levitsky V.G.1,2, Mironova V.V.1,2 Novosibirsk State University, 2 Pirogova Street, Novosibirsk, 630090, Russian Federation ;Institute of Cytology and Genetics, Lavrentyeva avenue 10, Novosibirsk, 630090, Russian Federation; Department of Agrotechnology and Food Sciences, Subdivision Biochemistry, Wageningen University and Research Center, Stippeneng 4, Wageningen, 6708WE, Netherlands Plant16 Study of the effect of nanocomposites based on humic substances of different nature on the causative agent of ring rot of Clavibacter michiganensis ssp. sepedonicus potato plants. O.A. Nozhkina1 *, A. I. of Perfilyeva1, I. A. of Graskova1, B. G. Sukhov2 1 Siberian Institute of physiology and biochemistry of plants of the Siberian Branch of the Russian Academy of Science, Irkutsk, Russia 2 Irkutsk Institute of chemistry of A.E. Favorskii of the Siberian Branch of the Russian Academy of Science, Irkutsk, Russia Plant17 Mathematical modeling of chilling stress induced changes in Arabidopsis thaliana root meristem Savina M.S.1,2*, Jing Han Hong3, Jian Xu3, Mironova V.V. 1,2 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia ; 2Novosibirsk State University, Novosibirsk, Russia; 3Department of Biological Sciences and Centre for BioImaging Sciences, National University of Singapore, Singapore, Singapore; Plant18 Establishment of a Regional Centre for DNA-barcoding of Rare and Endangered Plant Species based on the DNA Bank of the Republic of Belarus N.Savina 1*, S.Kubrak1, Е.Kuzminova1, E.Mikhalenko1, L.Milko1, A.Kolbas2, N.Matusevich2, E.Makeyeva1 , A.Kilchevskiy1 1Institute of Genetics and Cytology NASB, Minsk, Belarus; 2 Brest State University named after A.S. Pushkin, Brest, Belarus Plant19 The Novel Tandem Repeat of 646 bp Identifies the Subtelomeric Region of Wheat 5BS Chromosome Sergeeva E.M.1*, Adonina I.G.1, Nesterov M.A.1, Salina E.A.1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Plant20 The Evaluation of Reproduction Type of Puccinia graminis f. sp. tritici Population Prevailing in West Siberia Sergeeva E.M.1*, Skolotneva E.S.1, Kelbin V.N.1, Konkova S.I.2, Nesterov M.A.1, Salina E.A.1 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk State University, Novosibirsk, Russia Plant21 Regulatory genes of anthocyanins biosynthesis in the barley grain K.V. Strygina1*, E.K. Khlestkina1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant22 Genes determining anthocyanin pigmentation in Solanum tuberosum L. K.V. Strygina*, E.K. Khlestkina, A.V. Kochetov Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Plant23 Application of SRAP fingerprinting for analysis of L. angustifolius cDNA E.Sysoliatin*, N.Anisimova, A.Kilchevsky Institute of Genetics and Cytology, NAS of Belarus, Minsk, Belarus Plant24 Discordant evolution of YUCCA family proteins demonstrated along sequence I. Turnaev1*, K. Gunbin1, V. Suslov1, D. Afonnikov1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Plant25 Computational modelling of morpho-genesis based on data from 3D LSM-images U. Zubairova1*, A. Doroshkov1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia 2 Novosibirsk State University, Novosibirsk, Russia

SYMPOSIUM Single-cell genomics: Neuroscience, Biodiversity and Evolution» BioGenEvo-2018 22-23 August 2018

BGE1 Genetic Diversity of Plantago major L. Local Populations in the Habitats of Nizhniy Tagil Different in the Level of Technogenic Load E. Artemenko*, E. Zhuikova, I. Kiseleva Ural Federal University, Yekaterinburg, Russia BGE2 Genetic Diversity of Taraxacum Officicnale Wigg. Local Populations in the Habitats of Nizhniy Tagil Different in the Level of Technogenic Load E. Artemenko, E. Zhuikova, I. Kiseleva Ural Federal University, Yekaterinburg, Russia BGE3 Repeated DNA Sequences in Genomes of Species of the Genus Linum N. Bolsheva1, I. Kirov2, N. Melnikova1, A. Dmitriev1, G. Krasnov1, А. Amosova1, T. Samatadze1, O. Yurkevich1, S. Zoshchuk1, T. Rozhmina1, 3, A. Kudryavtseva1, O. Muravenko1 1 Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia; 2 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia; 3 All-Russian Research Institute for Flax, Torzhok, Russia BGE4 Genetic Diversity of Cultivated Flax Based on CesA Genes Dmitriev1, T. Rozhmina1, 2, G. Krasnov1, A. Snezhkina1, R. Novakovskiy1, P. Kezimana1, N. Bolsheva1, O. Muravenko1, A. Kudryavtseva1, N. Melnikova1 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2 All-Russian Research Institute for Flax, Torzhok, Russia BGE5 Evolutionary Patterns of piRNA-generating Clusters in Human Genome O. Dolgova1, R. Mulet2, L. Llobet3, S. Casillas2, T. Vavouri3 1 Population Genomics Team, Centre Nacional d’Anàlisi Genòmica, Barcelona, Spain; 2 Institut de Biotecnologia i Biomedicina and Department de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Barcelona, Spain; 3 Josep Carreras Leukaemia Research Institute, Barcelona, Spain BGE6 Biological diversity of the bacterial community of the Vostok bay (Japan Sea) by high- throughput sequencing Y.S. Golozubova, L.S. Buzoleva, E.A. Bogatyrenko Far Eastern Federal University, Vladivostok, Russia BGE7 Searching for signatures of cold adaptation in human TRP genes A.V. Igoshin1, K.V. Gunbin1, N.S. Yudin1, 2, M.I. Voevoda1, 2, 3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Internal and Preventive Medicine – branch of ICG SB RAS, Novosibirsk, Russia BGE8 Polymorphism in Genes Related to Fatty Acid Composition in Linum usitatissimum P. Kezimana1, 2, A. Dmitriev1, T. Rozhmina1, 3, R. Novakovskiy1, E. Romanova2, A. Kudryavtseva1, N. Melnikova1 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; 2 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia; 3 All-Russian Research Institute for Flax, Torzhok, Russia BGE9 Evolutionary study of low complexity glycine-arginine rich domains Kotyurgin1, A. Alexeevski1, 2 1 Lomonosov Moscow State University, A.N. Belozersky Institute of Physico-Chemical Biology and Faculty of Bioengineering and Bioinformatics, Moscow, Russia; 2 Scientific Research Institute for System Analysis RAS, Moscow, Russia BGE10 Phylogenetic Analysis of Genes Encoding the Enzymes of Plant Amino Acids Catabolism in Representatives of the Genus Methylobacterium M. Krohaleva1, D. Fedorov2, G. Ekimova2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Biochemistry and Physiology of Microorganisms RAS, Pushchino, Russia BGE11 Finding shifts in the evolution of mitochondrial metabolism A.A. Kuzminkova1, K.Yu. Popadin1, 2, K.V. Gunbin1, 3 1 School of Life Science, Immanuel Kant Federal Baltic University, Kaliningrad, Russia; 2 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE12 Recombination landscapes in eight avian species L. Malinovskaya1, 2, N. Torgunakov2, A. Torgasheva1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia BGE13 Massive Inter-Phylum Lateral Gene Transfer from Planctomycetes: the Case of TIGR02604 Family of the Putative Glycoside Hydrolases D.G. Naumoff Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia BGE14 Metagenomic Analysis of Metabolically Active Microbial communities of Salenoye Lake #48 in the Novosibirsk Region Rozanov1, A. Shipova1, 2, A. Bryanskaya1, E. Lazareva3, O. Taran4, S. Peltek1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Geology and Mineralogy SB RAS, Novosibirsk, Russia; 4 Boreskov Institute of Catalysis SB RAS, Novosibirsk, Russia BGE15 Challenges of in vitro conservation of Сitrus genetic resources L.S. Samarina1, V.I. Malyarovskaya1, R.S. Rakhmangulov1, Y.L. Orlov2, O.B. Dobrovolskaya2 1 Russian Research Institute of Floriculture and Subtropical Crops, Sochi, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE16 Polymorphism in the Promoter Region of the Squalene Synthase Gene in different amaranth species A.B. Shcherban, A.I. Stasyuk, E.A. Salina Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE17 An intron of the hsp90 gene as a new promising phylogenetic marker for the genus Carex L. I.N. Shekhovtsova1, S.V. Shekhovtsov2, 3, S.E. Peltek2 1 3 Central Siberian Botanical Garden SB RAS, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Institute of Biological Problems of the North FEB RAS, Magadan, Russia BGE18 Revised molecular phylogeny of Acrididae family I. Sukhikh1, K. Ustyantsev1, V. Vavilova1, A. Blinov1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Immunology and Physiology UB RAS, Yekaterinburg, Russia BGE19 Homologous series and parallel evolution problem V. Suslov, M. Ponomarenko, D. Rasskazov Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE20 Endosymbiotic Bacteria Wolbachia in Siberian Populations of Acrididae grasshopper (Orthoptera Tikhomirova1, M. Yudina1, 2, G. Yurlova2, R. Bykov2, A. Bugrov1, 3, Yu. Ilinsky1, 2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3 Institute of Systematics and Ecology of Animals SB RAS, Novosibirsk, Russia BGE21 The reasons for mtDNA structural instability: evolutionary physico-chemical retrospective V.N. Timonina1, D.A. Knorre2, K.Yu. Popadin1, 3, K.V. Gunbin1, 4 1 School of Life Science, Immanuel Kant Federal Baltic University, Kaliningrad, Russia; 2 A.N. Belozersky Institute of Physico-Chemical Biology, MSU, Moscow, Russia; 3 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; 4 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE22 Specific anthrax bacteriophages as a factor for selection of subcultures with different phenotypic and genetic characteristics out of populations of Bacillus anthracis strains O.I. Tsygankova, E.A. Koteneva, А.V. Kalinin Stavropol Plague Control Research Institute, Stavropol, Russia BGE23 Fractal analysis of otolith microrelief as a method for determines relationship of species M.L. Tyagun1, А.А. Golovko2 1 Limnological Institute SB RAS, Irkutsk, Russia; 2 Institute of Solar-Terrestrial Physics SB RAS, Irkutsk, Russia BGE24 Genomic characterization of DEP1 gene in the Triticinae species with compact, compactoid and normal spike shape V. Vavilova, I. Konopatskaia, A. Blinov Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia BGE25 Genetic Diversity and Phylogeny of Wolbachia in Lepidopteran Hosts M. Yudina1, 2, V. Dubatolov3, R. Bykov1, I. Mazunin4, Yu. Ilinsky1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Systematics and Ecology of Animals SB RAS, Novosibirsk, Russia; 4 Immanuel Kant Baltic Federal University, Kaliningrad, Russia BGE26 Allelic Diversity of the GJB2 Gene in Deaf Patients and Ethnically Matched Populations from South Siberia M. Zytsar1, 2, M. Bady-Khoo3, E. Maslova1, 2, V. Danilchenko1, 2, N. Barashkov4, 5, I. Morozov2, 6, A. Bondar6, O. Posukh1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Scientific Research Institute of Medical-Social Problems and Management of the Republic of Tuva, Kyzyl, Russia; 4 Laboratory of Molecular Biology, MK Ammosov North-Eastern Federal University, Yakutsk, Russia; 5 Laboratory of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Yakutsk, Russia; 6 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia BGE27 Haplotype Analysis of the HFE Gene Among Patients with Different Forms of Tick- borne Encephalitis S. Mikhailova1, A. Barkhash1, I. Kozlova2, I. Borischuk3, N. Yudin1, O. Zaitseva4, L. Pozdnyakova5, M. Voevoda1 1 Federal Research Centre Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Federal State Public Scientific Institution “Scientific Centre for Family Health and Human Reproduction Problems”, Irkutsk, Russia; 3 Irkutsk Regional Infectious Clinical Hospital, Irkutsk, Russia; 4 Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarsk Science Center” SB RAS, Krasnoyarsk, Russia; 5 City Infectious Clinical Hospital No. 1, Novosibirsk, Russia

MHB1 Algorithm for solving the inverse problem of pharmacokinetics to determine the transition coefficients A. Takuadina L.N. Gumilev Eurasian National University, Astana, Kazakhstan MHB2 Mathematical modeling of medicinal preparations diffusion process in tissues of the person A. Nafikova Sterlitamak branch of the Bashkir state university, Sterlitamak, Russia MHB3 Mathematical model of membrane potential formation at E. coli growth on nitrite N.A. Ree, Likhoshvai V.A., T.M. Khlebodarova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia MHB4 Different effects of agroclimatic factors on time to emergence and time to flowering in nine soybean accessions K. Kozlov1, L. Novikova1, 2, I. Seferova2, S. Nuzhdin1, 3, M. Samsonova1 1 Peter the Great St.Petersburg Polytechnic University, St.Petersburg, Russia; 2 Federal Research Center the N.I. Vavilov All-Russian Institute of Plant Genetic Resources, St. Petersburg, Russia; 3 University of Southern California, Los Angeles, CA, USA MHB5 A numerical algorithm of parameter identification in mathematical model of tuberculosis transmission with control programs S.I. Kabanikhin1, 2, O.I. Krivorotko1, 2, V.N. Kashtanova2 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia MHB6 Inverse and ill-posed problems for nonlinear PDE: applications to life and social sciences M. Shishlenin1, 2, 3, D. Lukyanenko4 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Sobolev Institute of Mathematics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia; 4 Moscow State University, Moscow, Russia MHB7 Pseudo one-compartment models. Methods for assessing the peripheral compartment for them N. Asmanova, A.I. Ilin JSC “Scientific center for anti-infection drugs”, Almaty, Kazakhstan MHB8 Revealing the research institutes and their interactions: a case study of miRNA research A. Firsov1, I. Titov2 1 Novosibirsk State University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia MHB9 Comparison of quality of automated Gene Network Recon-struction using connectivity of random and functional Net-works E. Tiys1, 2, P. Demenkov1, V. Ivanisenko1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia MHB10 Principal component analysis for any type sequences (PCA-Seq) V. Efimov1, 2, 3, 4, K. Efimov5, V. Kovaleva2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Systematics and Ecology of Animals SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia; 4 Tomsk State University, Tomsk, Russia; 5 Moscow Institute of Physics and Technology (State University), Moscow, Russia MHB11 Identifiability analysis of mathematical models of immunology and epidemiology V. Latyshenko1, 2, O. Krivorotko1, 2, S. Kabanikhin1 1 Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia MHB12 FoldGO for functional annotation of transcriptome data to identify fold-change- specific GO categories S. Wiebe1, 2, A.M. Mukhin1, 2, N.A. Omelyanchuk1, 2, V.V. Mironova1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia MHB13 SNP_TATA_Z-TESTER: unsupervised machine learning web-service to compare alternative sequences in front of a given transcription start in the affinity scale of tata- binding protein binding to promoters P. M. Ponomarenko1 , D. A. Rasskazov2 , V. V. Suslov2 and M. P. Ponomarenko2,3 1 University of La Verne, La Verne, CA 91750, USA; 2 Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia MHB14 Genome-scale modeling of carbon assimilation in Geobacillus icigianus M. Kulyashov1, I. Akberdin1, 2, 3, A. Rozanov2, S. Peltek2 1 Novosibirsk National Research University, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3 Biology Department and Viral Information Institute, San Diego State University, San Diego, USA MHB15 Dynamic Modelling of CFTR Receptor Maturation in Cystic Fibrosis: What Controls the Receptor Concentration in the Plasma Membrane? Daria Astapenko*1, 2, Hugo M. Botelho3, Alexey Kolodkin2, 4, 5, 6, 7, Hans V. Westerhoff 3,6,7,8, Margarida D. Amaral3. 1Novosibirsk State University, Novosibirsk, Russia; 2Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3Biosystems and Integrative Sciences Institute (BioISI) of the University of Lisbon; 4Infrastructure for Systems Biology Europe (ISBE); 5Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxemburg; 6Molecular Cell Physiology, VU University Amsterdam, the Netherlands; 7Synthetic Systems Biology, SILS, University of Amsterdam, the Netherlands; 8Manchester Centre for Integrative Systems Biology, UK

SECTION «Proteomics» 23 August, Thursday

Prot1 The study of protein composition of Triaenophorus sp. at different stages of the life cycle and in different body segments A. Kochneva1, E. Borvinskaya1,2, D. Bedulina2 1Institute of Biology of the Karelian Research Centre of the Russian Academy of Sciences, Petrozavodsk, Russia; 2Research Institute of Biology of Irkutsk State University, Irkutsk, Russia 1 Prot2 Protein structural domain prediction via machine learning approach D. Iakovlev , A. Kobchenko, E. Semina 1 Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia Prot3 Proteomic analysis of extremely stable soluble high molecular mass multi-protein complex of human placenta E. Burkova1, G. Nevinsky1,2 1 Institute of Chemical biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Prot4 The search of blood-based biomarkers for schizophrenia by proteomics methods E. Dmitrieva1, L. Smirnova1, A. Seregin1, A. Letova3, E. Kornetova1, A. Semke1, V. Zgoda 2 and S. Ivanova1 1 Mental Health Research Institute, Tomsk, Russia; 2 Institute of Biomedical Chemistry, Moscow, Russia; 3 Siberian State Medical University, Tomsk, Russia Prot5 Milk exosomes: isolation, proteins, and nucleic acids L. Purvinsh1,2, S. Sedykh1,2, G. Nevinsky2 1. Novosibirsk State University, Novosibirsk, Russia; 2. Institute of Molecular Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia Prot6 Comparative proteomic analysis form patients with schizophrenia and bipolar disorder L.P. Smirnova1*, E.M. Dmitrieva1, A.A. Letova2, A.A. Seregin1 G.G. Simutkin1, A.V. Semke1 and S.А. Ivanova1 1. Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia; 2. Siberian State Medical University, Tomsk, Russia Prot7 Novel Amyloid-Forming Protein in Escherichia coli M. Belousov1, S. Bondarev1, A. Kosolapova1, 2, K. Antonets1, 2, M. Belousova2, A. Sulatskaya3, M. Sulatsky3, G. Zhouravleva1, I. Kuznetsova3, K. Turoverov3, 4, A. Nizhnikov1, 2 1 Saint Petersburg University, Saint Petersburg, Russia; 2 All-Russia Research Institute for Agricultural Microbiology, Pushkin, Saint Petersburg, Russia; 3 Institute of Cytology RAS, Saint Petersburg, Russia; 4 Peter the Great St Petersburg Polytechnic University, Saint Petersburg, Russia Prot8 Statistical Analysis of Macromolecular B Values R. Masmaliyeva1*, G. N. Murshudov 2 1 Institute of Molecular Biology and Biotechnologies ANAS, Baku, Azerbaijan; 2 MRC Laboratory of Molecular Biology, Cambridge, UK Prot9 Molecular design of a new class of inhibitors for ion channel of influenza a protein M2 Y. N. Vorobjev, O.S. Fedorova Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia Prot10 Effect of Salt Bridges Rupture on The Activity and Thermostability of Chymosin E.S. Novoselova1*, Rudometov A.P.2, Kriger A.V.3, Elchaninov V.V3. 1Novosibirsk State University, Novosibirsk, Russia; 2State Research Center of Virology and Biotechnology "Vector" Rospotrebnadzor, Koltsovo, Russia; 3Federal Altai Scientific Centre of Afro-BioTechnologies, Barnaul, Russia Prot11 The secretome of Serratia marcescens SM6 under oxidative stress conditions L.Е. Matrosova1, I.V. Khilyas1, L.M. Bogomolnaya1,2 1 Institute of Fundamental Medicine and Biology KFU, Kazan, Russia; 2 Texas A&M University Health Science Center, Bryan, 77807, Texas, USA Prot12 MOLECULAR CHARACTERIZATION of AQUAGLYCEROPORINE: A NOVEL MUTATION IN LMAQP1 from LEISHMANIA MAJOR (MRHO/IR/75/ER) G. Eslami*, M. Ghavami Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Prot13 Study of pathogenic features of stress-related disorders by proteomics methods A. Seregin1, L. Loginova1, Anastasiya Letova2 , E. Dmitrieva1, N Karageorgiy3, V. Rudnitckiy1, L. Smirnova1 1 Mental Health Research Institute, Tomsk National Research Medical Center of the RAS, Tomsk, Russia; 2 Siberian State Medical University, SSMU, Tomsk, Russia; 3 Tomsk State Pedagogical University, Tomsk, Russia

SECTION « Animal genetics » 23-24 August Anim1 Studying the impact of sex on the molecular mechanisms of liver adaptation to fasting in mice N. Bazhan1,2*, N. Sitnikova2, T. Iakovleva1, A. Dubinina N1, E. Makarova1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Anim2 The roles of Asp and Patronin in mitotic spindle formation in Drosophila A. Razuvaeva1,2*, G. Pavlova1, J. Popova1,3, L. Yarinich1,2, M. Lebedev1,2, E. Andreyeva1, A. Anders1,2, M. Gatti4, A. Pindyurin1,2,3 1 Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia; 3 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 4 Sapienza University of Rome, Rome, Italy Anim3 Aldosterone Mineralocorticoid Receptors Expression in Male Ay Mice N.S. Logvinenko*, L.E. Katkova, G.S. Baturina Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Anim4 FGF21 signaling and brown adipose activity gene expressions in male and female mice under fasting and refeeding states T. Iakovleva1*, N. Balybina2, N. Makarova1, N. Bazhan1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Anim5 The Moonlighting Functions of the NON3 Protein in Drosophila melanogaster J. Popova1,2*, G. Pavlova1, E. Andreyeva1, A. Ogienko1, A. Yushkova1,3, A. Ivankin1, E. Kozhevnikova1,2, A. Pindyurin1,2,3 1 Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia; 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia Anim6 Lethal yellow (AY) mutation in the agouti gene causes the depressive-like alterations in the mouse brain and behavior A.V. Plyusnina1*, N.V. Khotskin1, E.A. Kulikova1, E.Y. Bazhenova1, D.V. Fursenko1, I.E. Sorokin1, I. Kolotygin2, O.B. Shevelev1, A.V. Kulikov1 1Federal Research Center Institute of Cytology and Genetic SB RAS, 630090, Novosibirsk, Russia; 2Novosibirsk State University, 630090, Novosibirsk, Russia Anim7 Sex-specific effect of leptin on gene expression in placentas and fetal tissues in mice E. Denisova*, E. Makarova Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Anim8 Oxidative stress and nitric oxide synthesis in ISIAH rats with inherited stress- induced arterial hypertension L. Klimov1, 2*, M.Zhuravina1, 2 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2Novosibirsk StateUniversity, Novosibirsk, Russia Anim9 Comparative experimental analysis of the reproductive poten-tial and sexual behavior of house mice from the Transcauca-sian hybrid zone and Mus musculus. E. Kotenkova1*, A. Maltsev1, A. Ambaryan1 1Severtsov Institute of Ecology and Evolution RAS, Moscow, Russia Anim10 Taurine Affects the Predisposition to Audiogenic Epilepsy in PM Rats O.I. Prokudina1*, T.A. Alekhina1, A.V. Solovyeva2 1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Altai State University, Barnaul, Russia Anim11 Astrocyte-to-neurone Lactate Communication in the Brain A.G. Teschemacher*, B.V. Cardoso, V. Mosienko, B.H. Liu, S. Kasparov University of Bristol, United Kingdom Anim12 FTO haplotyping underlines high obesity risk for European populations. R.O. Babenko, V.N. Babenko*, L.N. Trut, A.L. Markel Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Anim13 Selection for Behavior, Intermale Confrontations, and Corticosterone and Testosterone Levels in the Blood of Norway Rats R.Gulevich1*, R. Kozhemyakina1, M. Konoshenko2, S. Shikhevich1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russial; 2 Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Anim14 Expression of Th, Comt and Maoa Genes and Brain Catecholamine Levels in Rats with Genetic Catatonia M. Ryazanova1,3*, T. Latysheva2, V. Plekanchuk1,3, O. Prokudina 1, M. Gilinsky2, T. Alekhina1 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia Anim15 The impact of rapid decrease of Aporia crataegi (Lepidoptera: Pieridae) population size on Wolbachia infection rate G. Yurlova1*, R. Bykov1, M. Yudina1,2, A. Tikhomirova2, O. Kosterin1,2, Yu. Ilinsky1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia Anim16 High Wolbachia Infection Rate in Four-Eyed Fir Bark Beetle (Polygraphus proximus) Populations of Tomsk Province R. Bykov1, I. Kerchev2, M. Yudina1, 3, G. Yurlova1, A. Tikhomirova3, Yu. Ilinsky1, 3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Institute of Systematics and Ecology of Animals SB RAS, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia Anim17 Wolbachia and mtDNA Diversity and Distribution in Palearctic Drosophila melanogaster Populations

R. Bykov1*, I. Mazunin2, M. Yudina1, 3, Yu. Ilinsky1, 2, 3 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 3 Novosibirsk State University, Novosibirsk, Russia Anim18 Effect of Stress-related Hormones on Host Drosophila Fitness Depends on Endosymbiont Wolbachia Genotype N. Adonyeva, E. Burdina, N. Gruntenko, I. Rauschenbach Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

SYMPOSIUM

«Cognitive sciences, genomics and bioinformatics» CSGB-2018 24 August, Friday CSGB 1. The long-term consequences of early-life dexamethasone treatment on the cognitive ability of male mice and gene expression in the hippocampus U.I. Batluk1, 2, K.V. Burdeeva3, A.O. Degtyareva1, O.M. Dolganova1, 3, N.I. Ershov1, T.I. Merkulova1, 2, N.P.Bondar1, 2 1 Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia; 2 National Research Novosibirsk State University, Novosibirsk, Russia; 3 Novosibirsk State Medical University, Novosibirsk, Russia CSGB 2. Cognitive activity and students' coping strategies S. Krivoschekov1, E. Vergunov1, N. Balioz1, K. Soloveva2, E. Bobrovskaya2 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Novosibirsk State University of Economics and Management, Novosibirsk, Russia CSGB 3. Impact of early life stress on susceptibility to chronic social stress in adult mice A. Lepeshko1, 2, V. Reshetnikov1, N. Bondar1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia CSGB 4. Temporo-parietal junction as a mediator of reactive social behavior: The role of agreeableness E. Merkulova, A. Savostyanov, A. Bocharov, G. Knyazev Laboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, Novosibirsk, Russia CSGB 5. Effects of the endothelial nitric oxide synthase gene polymorphisms on the risk of metabolic syndrome in subjects with schizophrenia D. Parshukova, N. Fattakhov, L. Smirnova, V. Dubrovskaya, E. Kornetova, A. Semke, S. Ivanova Mental Health Research Institute, Tomsk, Russia CSGB 6. Neurophysiological features of verbal divergent thinking in elderly scientists E. Privodnova1, N. Volf1, 2 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia CSGB 7. The effect of 5-HTTLPR polymorphism on EEG current source density E. Proshina1, A. Savostyanov1, 2, 3, A. Bocharov1, 3, G. Knyazev1 1 Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia; 2 Institute of Cytology and Genetics, Novosibirsk, Russia; 3 Novosibirsk State University, Novosibirsk, Russia CSGB 8. Previous mother’s experience and early life stress: impact on aggression and cognition in adult mice V.V. Reshetnikov1, Yu.A. Ryabushkina1, 2, N.P. Bondar1, 2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia CSGB 9. Reconstruction of Gene Networks Associated with Autism and Related to mTOR Signaling Pathway using ANDSystem O.V. Saik, E.A. Trifonova, T.M. Khlebodarova, V.A. Ivanisenko Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia CSGB 10. Effect of ceftriaxone on cognitive deficits caused by amyloid-beta neurotoxicity in mice A.E. Tishin1, 2, M.V. Tenditnik1, 2, M.A. Tikhonova1, 2 1 Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia CSGB 11. The effects of 5-HTTLPR gene polymorphism on the behavioral reactions under emotional speech recognition among Mongolians M.S. Vlasov1, D.V. Bazovkina3, S.S. Tamozhnikov2, T.A. Ausheeva4, A.N. Savostyanov2, 3, 4 1 Shukshin Altai State Humanities Pedagogical University, Biysk, Russia; 2 Institute of Physiology & Basic Medicine, Novosibirsk, Russia; 3 Institute of Cytology and Genetics of SB RAS, Novosibirsk, Russia; 4 Novosibirsk State University, Novosibirsk, Russia CSGB 12. Association of PIP5K2A gene polymorphisms with the effectiveness of the therapy of current depressive episode N.M. Vyalova, G.G. Simutkin, S.A. Ivanova Mental Health Research Institute of the Federal State Budget Scientific Institution, Tomsk, Russia CSGB 13. Impact of early life stress on cognition, behavior and hippocampal neuronal plasticity in female mice V. Reshetnikov1*, A. Kovner1, J. Ryabushkina1,2, A. Lepeshko1,2, N. Bondar1,2 1 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; 2 Novosibirsk State University, Novosibirsk, Russia