37Th International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics 43
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Pteridines 2018; 29: 42–69 Abstracts Open Access Fuchs D (Innsbruck, Austria), Gostner JM (Innsbruck, Austria), Griesmacher A (Innsbruck, Austria), Melichar B (Olomouc, Czech Republic), Reibnegger G (Graz, Austria), Weiss G (Innsbruck, Austria), Werner ER (Innsbruck, Austria) 37th International Winter-Workshop Clinical, Chemical and BiochemicalJournal xyz 2017; Aspects1 (2): 122–135 of Pteridines The Firstand Decade Related (1964-1972) Topics Research Article Innsbruck, February 20th – 23rd, 2018 Max Musterman, Paul Placeholder Whathttps://doi.org/10.1515/pteridines-2018-0006 Is So Different About received April 13, 2018; accepted May 8, 2018. Primary criterion of evaluation was the forced Neuroenhancement? expiratory volume in the first second (FEV1). Secondary Was ist so anders am Neuroenhancement?criteria were subjective sensations, further lung function parameters such as airway resistance, physical Tolerability of inhaled N-chlorotaurine examination, and blood analyses (gases, electrolytes, Pharmacological and Mental Self-transformation in Ethic – a phase I clinical study organ function values, pharmacokinetic parameters Comparison taurine and methionine, immune parameters). PharmakologischeArnitz A, Stein M, und Bauer mentale P, Lanthaler Selbstveränderung B, Jamnig H, Scholl- im All included 15 females and 9 males completed the ethischenBürgi VergleichS, Stempfl-Al-Jazrawi K, Ulmer H, Baumgartner B, treatment and the control examinations according to the Embacher S, Geisler S, Gostner JM, Müllinger B, Kälz B, Nagl M study protocol. FEV1 and all other objective parameters https://doi.org/10.1515/xyz-2017-0010District Hospital Vöcklabruck, Department of Pneumology, remained unchanged and constant during the treatment received Vöcklabruck,February 9, 2013; Austria; accepted Public March Hospital25, 2013; publishedNatters, Departmentonline July 12, 2014and in control examinations 1 week and 3 months after of Pneumology, Natters, Austria; Clinical Trial Center, the treatment. Subjective mild sensations with a higher Abstract: In the concept of the aesthetic formation of knowledge and its as soon Medical University of Innsbruck, Innsbruck, Austria; frequency in the test group were chlorine taste (P <0.01) as possible and success-oriented application, insights and profits without the Departments of Pediatrics I (Inherited Metabolic Disorders), and occasional tickle in the throat (P = 0.057). Taurine, reference to the arguments developed around 1900. The main investigation also Department of Medical Statistics, Informatics and Health methionine, neopterin, tryptophan, and kynurenine includes the period between the entry into force and the presentation in its current Economics, Division of Medical Biochemistry, Biocenter, plasma concentrations did not change within 60 min after version. Their function as part of the literary portrayal and narrative technique. Division of Hygiene and Medical Microbiology, Medical inhalation or later on. Keywords:University Function, of transmission,Innsbruck, Innsbruck,investigation, Austria; principal, Vectura period Inhaled NCT is well tolerated with only mild, topical GmbH, Gauting, Germany; Sanochemia Pharmazeutika AG, and transitory subjective side effects. DedicatedNeufeld, to Paul Placeholder Austria ([email protected]) N-chlorotaurine (NCT), an endogenous antiseptic Biomarkers of immune and 1 Studiesapplicable and to differentInvestigations body regions was tested on its inflammatory response and the tolerability upon inhalation in humans. This was a The main investigation also includes the period between the entry into force and double-blind and randomized study with a parallel test response to therapy with immune the presentation in its current version. Their function as part of the literary por- (1% NCT) and control group (0.9% NaCl as placebo) in two trayal and narrative technique. checkpoint inhibitors in patients Austrian centers, the hospitals Natters and Vöcklabruck. Healthy, full age volunteers were included, 12 in each with solid tumors center. Exactly the half of each group was treated in each *Max Musterman: Institute of Marine Biology, National Taiwan Ocean University, Bartoušková2 Pei-Ning M, Spisarová M, Zezulová M, Vitásková D, center. One inhalation (single dose 1.2 ml each, inhaled Road Keelung 20224, Taiwan (R.O.C), e-mail: [email protected] Študentová H, Javorská L, Kujovská-Krčmová L, Solichová for 10 min) was done on every day on 5 consecutive days Paul Placeholder: Institute of Marine Biology, National Taiwan Ocean University, 2 Pei-NingD, Adam T, Melichar B Road Keelungusing 20224, an AKITA Taiwan JET (R.O.C), nebulizer. e-mail: [email protected] Journal xyz 2017; 1 (2): 122–135Open Access. Open © 2017 Access. Mustermann © 2018 and ???? Placeholder, et al., published published by by De De Gruyter. Gruyter. ThisThis work work is is licensed under the Creative Commons Attribution- licensed underNonCommercial-NoDerivatives the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. 4.0 License. The First Decade (1964-1972) Research Article Max Musterman, Paul Placeholder What Is So Different About Neuroenhancement? Was ist so anders am Neuroenhancement? Pharmacological and Mental Self-transformation in Ethic Comparison Pharmakologische und mentale Selbstveränderung im ethischen Vergleich https://doi.org/10.1515/xyz-2017-0010 received February 9, 2013; accepted March 25, 2013; published online July 12, 2014 Abstract: In the concept of the aesthetic formation of knowledge and its as soon as possible and success-oriented application, insights and profits without the reference to the arguments developed around 1900. The main investigation also includes the period between the entry into force and the presentation in its current version. Their function as part of the literary portrayal and narrative technique. Keywords: Function, transmission, investigation, principal, period Dedicated to Paul Placeholder 1 Studies and Investigations The main investigation also includes the period between the entry into force and the presentation in its current version. Their function as part of the literary por- trayal and narrative technique. *Max Musterman: Institute of Marine Biology, National Taiwan Ocean University, 2 Pei-Ning Road Keelung 20224, Taiwan (R.O.C), e-mail: [email protected] Paul Placeholder: Institute of Marine Biology, National Taiwan Ocean University, 2 Pei-Ning Road Keelung 20224, Taiwan (R.O.C), e-mail: [email protected] Open Access. © 2017 Mustermann and Placeholder, published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. 37th International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics 43 Palacký University Medical School and Teaching Hospital, is difficult. Adverse social life events in mammals Olomouc, Czech Republic, and Charles University Medical (social stress) such as maternal/peer-separation or School and Teaching Hospital, Hradec Králové, Czech social defeat, causes long term social incompetence and Republic major disruptions in both immune and neurotransmitter ([email protected]) systems, including the serotonin (5-HT) system. Feather pecking (FP), a widespread abnormal-repetitive behavior The advent of immune checkpoint inhibitors like directed at the feather cover/skin of other birds, leads to Ipilimumab or Nivolumab has virtually transformed the integument injuries. It is suggested that FP is a tryptophan management of solid tumors. However, only a minority (TRP)/5-HT-related disorder. However, the TRP aetio- of patients does respond to this toxic and expensive pathophysiology is poorly understood. To help address therapy, and the search for reliable predictive biomarkers this situation we investigated by HPLC and ELISA methods of immunotherapy reflects an unmet medical need. In the relationship between psychosocial stress, activation the present study, serum C-reactive protein (CRP) and of the TRP/kynurenine (KYN) pathway and FP behavior neopterin concentrations as well as peripheral blood cell in an experimental line divergently selected for FP. We count (PBC)-derived ratios were studied in melanoma used 160 laying hens selected for high (HFP) or low (LFP) patients treated with Ipilimumab. First preliminary data FP activity and an unselected control line (C). Birds were from this pilot in 28 patients with metastatic melanoma housed in floor pens in groups of 16 hens per pen (HFP; are presented. At baseline as well as during the treatment n=4, LFP; n=3, C; n=9, 10 pens). At 16 weeks of age, we both urinary neopterin and CRP significantly correlated disrupted the groups in 5 pens by mixing individuals with with PBC-derived ratios and lactate dehydrogenase (LDH). unfamiliar birds to simulate social stress. Blood plasma In multivariate analysis, neopterin, LDH and hemoglobin was collected one day prior to mixing and two days after were significant predictors of survival. In conclusion, both mixing, to determine amino acid concentrations for TRP, CRP and serum neopterin correlate with PBC-derived ratios phenylalanine to tyrosine ratios (PHE/TYR), KYN and in this patient population treated with immunotherapy. the immune system biomarker neopterin. Aggressive Neopterin concentrations represent a significantand feather pecking were recorded, but not presented in independent predictor of outcome in melanoma patients the present paper. Data were analyzed using a GLIMMIX treated with Ipilimumab. procedure in SAS. Social stress