Official Journal of AFSTAL, ECLAM, ESLAV, FELASA, GV-SOLAS, ILAF, LASA, NVP, SECAL, SGV, SPCAL
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Volume 53 Number 3 June 2019 ISSN 0023-6772 Laboratory Animals THE INTERNATIONAL JOURNAL OF LABORATORY ANIMAL SCIENCE, MEDICINE, TECHNOLOGY AND WELFARE Official Journal of AFSTAL, ECLAM, ESLAV, FELASA, GV-SOLAS, ILAF, LASA, NVP, SECAL, SGV, SPCAL Special Issue: Microbiota Published on behalf of Laboratory Animals Ltd. journals.sagepub.com/home/lan by SAGE Publications Ltd. Does your facility have all the right people with all the right skills? Your animal facilities can get the training, consulting, FDQKHOSƬOOWKHJDSVLQ\RXUSURJUDPPH:KHWKHU\RX DQGVWDƯQJVROXWLRQVWKH\QHHGZLWKInsourcing DUHORRNLQJIRUSHUPDQHQWRUWHPSRUDU\VWDƪZHFDQ SolutionsSM)URPUHJXODWRU\DQG&RQWLQXLQJ3URIHVVLRQDO TXLFNO\SURYLGHTXDOLƬHGSHUVRQQHOLQFOXGLQJEDFNJURXQG 'HYHORSPHQWWUDLQLQJWRSURYLGLQJIXOO\TXDOLƬHGDQLPDO FKHFNV7UDLQLQJDQGIXUWKHUHGXFDWLRQLVDYDLODEOHYLDRXU WHFKQLFLDQVYHWHULQDULDQVDQG3K'OHYHOVFLHQWLVWVZH classroom and eLearning solutions. Visit us at stand A15 at FELASA or at www.criver.com/insourcing Volume 53 Number 3 June 2019 Contents Special Issue: Microbiota Editorial Microbiota, laboratory animals, and research 229 AK Hansen and C Franklin Articles Gnotobiotics: Past, present and future 232 M Basic and A Bleich Humanizing the gut microbiota of mice: Opportunities and challenges 244 R Lundberg The gut microbiota of wild rodents: Challenges and opportunities 252 M Viney The use of non-rodent model species in microbiota studies 259 AC Ericsson The role of gut microbiota in intestinal and liver diseases 271 T Hrncir, L Hrncirova, M Kverka and H Tlaskalova-Hogenova Bacterial species to be considered in quality assurance of mice and rats 281 AK Hansen, DS Nielsen, L Krych and CHF Hansen Time to thank FELASA’s partners for their support 292 J-P Mocho More than 650.000 Euros given out in grants by Laboratory Animals Ltd in the past 10 years 297 Calendar of events/Index to advertisers 308 felasa TECH DAY clasa June 12, 2019 FELASA, the Federation of European Laboratory Animal Science Associations, represents over 4000 specialists in the field of laboratory animal science from 28 countries and 21 constituent associations. This triennial congress has grown to become the largest European laboratory animal science event attracting almost 2000 participants. This congress is always organized together with one of the FELASA Constituent Associations, which gives us all a great opportunity to familiarize ourselves with the cultural features of different countries in Europe. For this year the Constituent Association is CLASA, Czech Laboratory Animal Science Association. Prague is rightly considered to be one of the most beautiful cities in the world and proudly holds the name ‘Mother of Cities’. Whether it is knowledge or fun you seek, you will find yourself easily succumbing to its unparalleled and captivating atmosphere. The historical centre boasts of a rich plethora of architectural styles, from Gothic to Art Nouveau up to modern. The historical centre of Prague has been inscribed on the UNESCO World Heritage List. Prague is a city tailor-made for romance. Evening strolls through the narrow streets in the glow of old street lamps, exploring half-forgotten nooks and corners of the Old Town. Today, Prague is a cosmopolitan city where we find side by side restaurants with cuisines from around the world. However, amid this babel of flavours and aromas, you will still easily recognize a typical Czech restaurant with toothsome dishes, Czech beer on draught and excellent Moravian wine. Congress Secretariat: GUARANT International Na Pankráci 17, 140 21 Prague 4, Czech Republic Phone: +420 284 001 444, fax: +420 284 001 448 E-mail: [email protected] www.felasa2019.eu care in research. From genotyping to colony management, help of animals in research at your institution. animal models through trusted, outsourced genetic services at Transnetyx.com. Visit us at FELASA Booth A45-48 FLAWLESS PRECISION For over forty years, we have built our reputation on intertwining stringent quality standards with exemplary customer service. By working closely with the world’s leading scientific and biomedical research communities, we are able to provide you with a complete range of innovative, precision surgical and microsurgical instruments. At Fine Science Tools, you can always expect flawless product quality that is backed by our 100% satisfaction guarantee. Take your research further, faster – with Fine Science Tools. FINE SURGICAL INSTRUMENTS FOR RESEARCHTM Visit us at finescience.de or call +49 (0) 6221 905050 .............................................................................................................................................................................................217 Laboratory Animals Subscription information Annual subscription (2019) including postage: AALAS Member, (print and electronic) [US$120]. Combined Institutional Rate (print and electronic) [£304/US$562]. Electronic only and print Editorial Board only subscriptions are available for institutions at a discounted Editor-in-Chief B Riederer rate. Note VAT is applicable at the appropriate local rate. Deputy Editors G Jarvis, P Jirkof Visit sagepublishing.com for more subscription details. To activate your subscription (institutions only) visit Section Section Editors online.sagepub.com. Abstracts, tables of contents and contents alerts are available on this site free of charge Anaesthesia, Analgesia, P Flecknell, M Leach, P Foley, for all. Student discounts and single issue rates are available from Pain & Stress P Hedenqvist SAGE Publications Ltd, 1 Oliver’s Yard, 55 City Road, London EC1Y 1SP, UK, tel. þ44 (0)20 7324 8500, email subscriptions@sa- Anatomy and Neuroscience B Riederer, S Wells (neuro) gepub.co.uk and in North America, SAGE Publications Inc, Aquatic Organisms K Finger-Baier (fish), PO Box 5096, Thousand Oaks, CA 91320, USA. 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It is a registered charity (Registered Charity Number 261047) and Pathology & Microbiology P Clements, D Salvatori, none of its directors may receive any fee or remuneration. A Bleich Physiology & Clinical Chemistry M Sommers, T Hough Registered Office: Primates G Rainer, P Honess Laboratory Animals Ltd, 44 Springfield Road, Horsham, West 3Rs & Ethics G Griffin, A Olsson Sussex, RH12 2PD, UK Reproductive Biology H Hedrich, B Pintado, C Gilbert Council of Management Small Animal Models M Berard, J-B Prins (temporary), S Wells Chairman J-B Prins Surgical Procedures D Bouard, R Tolba Secretary E Weir Systematic Review M Ritskes-Hoitinga, Treasurer J Gregory BS Kousholt L Antunes P Nowlan Toxicology F Rutten K Applebee J Orellana Veterinary Medicine E Rivera, J Sanchez-Morgado, V Baumans B Riederer L Whitfield, M Berard A Ritchie N Kostomitsopoulos N Ezov M Ritkes-Hoitinga Special Issue Microbiota guest editor: C Gilbert A Shortland Axel Kornerup-Hansen and J Guillen S Wells Craig Franklin J Helppi M Wilkinson C Johner Comment and correspondence relating to editorial matters may be sent to the Chairman of the Editorial Board by email: laeditorial@- ß 2019 Laboratory Animals Ltd. 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