sign in sign up
<<
Home , Interventional radiology, Melvin Judkins, Radiology

Prepared: October 27, 2015

University of , San Francisco CURRICULUM VITAE

Name: Randall T Higashida, M.D. Position: Professor of Clinical , Step 7 Radiology School of Clinical Professor of Radiology & Biomedical Imaging, Neurological , , and

Address: Box 0628 505 Parnassus Ave, Long 349 University of California, San Francisco San Francisco, CA 94143 Voice: 415-353-1863 Fax: 415-353-8606 email: [email protected] www: http://www.radiology.ucsf.edu/people/faculty-directory/randall-higashida- bio

EDUCATION 1972 - 1976 University of Southern B.S. Biological California, , CA Sciences with emphasis in Biochemistry and Mathematics 1976 - 1980 Tulane University School of Medical Medicine Albert Hyman, Medicine, New Orleans, LA Doctor M.D.; Philip Kadowitz, Ph.D. 1980 - 1981 Harbor/UCLA Medical Center, Torrance, CA 1981 - 1984 UCLA Medical Center, Los Diagnostic Lawrence Angeles, CA Radiology Bassett, M.D. 1983 - 1983 Armed Forces Institute of Diagnostic (AFIP), , Radiology D.C. 1984 - 1985 UCLA Medical Center, Los Fellowship / Grant Hieshima, Angeles, CA Diagnostic and M.D.; John Interventional Bentson, M.D. Neuroradiology

LICENSES, CERTIFICATION

1980 Medical Board of California, and Surgeon

1980 Basic Cardiopulmonary Resuscitation

1 of 193 Prepared: October 27, 2015

1980 Advanced Life Support in Cardiopulmonary Resuscitation

1980 Federal Licensure Examination for Medical Boards

1984 American Board of Radiology (Certified) 1984 Radiology X-Ray Supervisor and Operator, California Department of Health Services

1996 Medical Board of Hawaii, Physician and Surgeon

PRINCIPAL POSITIONS HELD 1984 - 1985 UCLA Medical Center, Los Adjunct Instructor Angeles, CA in Radiology 1985 - 1986 UCLA Medical Center, Los Assistant Neuroradiology/ Angeles, CA Professor in Diagnostic and Radiology Interventional Section 1986 - 1990 UCSF Medical Center, San Assistant Neuroradiology, Francisco, CA Professor in Diagnostic/Intervention Residence of al Section Radiology 1986 - 1990 UCSF Medical Center, San Assistant Francisco, CA Professor in Residence of Neurological Surgery 1990 - 1994 UCSF Medical Center, San Associate Section of Francisco, CA Professor of and Neurovascular Neurological Radiology Surgery 1994 - present UCSF Medical Center, San Clinical Professor Division of Francisco, CA of Radiology and Interventional Neurological Neurovascular Surgery Radiology 1996 - present UCSF Medical Center, San Director and Chief Division of Francisco, CA Interventional Neurovascular Radiology 1996 - present UCSF Medical Center, San Clinical Professor, Neurological Surgery Francisco, CA Joint Appointment 2001 - present UCSF Medical Center, San Clinical Professor, Neurology Francisco, CA Joint Appointment 2001 - present UCSF Medical Center, San Clinical Professor, Anesthesiology Francisco, CA Joint Appointment 2012 - present UCSF Medical Center, San Clinical Professor, Radiology, Francisco, CA Step 7 Neurological Surgery, Neurology, & Anesthesiology

2 of 193 Prepared: October 27, 2015

OTHER POSITIONS HELD CONCURRENTLY 1986 - 1987 Letterman Army Medical Center Assistant Radiology Professor 1986 - 1987 Veteran's Affairs Medical Center, Assistant Radiology San Francisco Professor 1986 - 1987 San Francisco General Assistant Radiology Professor 1994 - 1995 Kaiser Permanente Medical Associate Radiology Center, Redwood City Professor/Clinical Staff 1995 - 1996 Kaiser Permanente Medical Associate Radiology Center, Sacramento Professor/Clinical Staff 1994 - 1996 Mt. Zion Medical Center, San Associate Radiology Francisco Professor 1994 - 2002 Hoag Memorial Hospital, Newport Consulting Staff Radiology Beach, California Physician 1995 - 2005 Queen's Medical Center, Honolulu, Associate Radiology Hawaii Professor/Clinical Staff 2012 - Present San Francisco Veteran's Clinical Professor Radiology Administration Medical Center 2014 - Present San Francisco General Hospital Clinical Professor Radiology

HONORS AND AWARDS 1978 Fellowship Grant and Research Award: 1978 and American 1979 Association 1980 Society: Award for Tulane University School of Outstanding Research Paper Medicine 1983 Radiological Sciences Department: James T. University of California, Los Case Cum Laude Award: 1983 and 1984; Magna Angeles: School of Cum Laude Award: 1985 Medicine

1985 Distinguished Lectureship and Visiting Professor Kyorin University School of Medicine, Japan

1987 Distinguished Lectureship and Visiting Professor Kyung Hee University, School of Medicine, South Korea

1988 Distinguished Lectureship and Visiting Professor University of New Mexico, School of Medicine

1988 Distinguished Lectureship and Visiting Professor University of Pennsylvania, School of Medicine

3 of 193 Prepared: October 27, 2015

1989 Distinguished Lectureship and Visiting Professor University of Minnesota, School of Medicine

1993 Distinguished Lectureship and Visiting Professor Creighton University, School of Medicine

1985 Cum Laude Award for Scientific Exhibit American Society of Neuroradiology

1990 Distinguished Lectureship and Visiting Professor Johns Hopkins University, School of Medicine

1990 Distinguished Lectureship and Visiting Professor University of Missouri, School of Medicine

1990 Distinguished Lectureship and Visiting Professor University of Maryland, School of Medicine 1991 Distinguished Lectureship: 50th Annual Scientific Japan Neurosurgical Meeting, Kyoto, Japan Society

1992 Distinguished Lectureship and Visiting Professor British Society of Neuroradiology and 1992 Honors in Reviewing: 1992, 1993, 1994, 1995, American Journal of 1996 Neuroradiology

1992 Distinguished Lectureship and Visiting Professor University of Michigan, School of Medicine

1992 Distinguished Lectureship and Visiting Professor Finland Society of Radiology

1993 Distinguished Lectureship and Visiting Professor Vanderbilt University, School of Medicine

1994 Distinguished Lectureship and Visiting Professor Dutch Society of 1994 Honorable Mention Wilson Award For Outstanding Western Neuroradiological Research Paper Society

1994 Distinguished Lectureship and Visiting Professor National Institute, Akita, Japan

1995 Distinguished Lectureship: Centennial Celebration Hong Kong College of Radiology, China

1995 Distinguished Lectureship and Visiting Professor Japan Congress of Neuroradiology

1995 Distinguished Lectureship and Visiting Professor Cleveland Medical Center

1995 Distinguished Lectureship and Visiting Professor Veterans Memorial Hospital, Taipei, Taiwan

1995 Distinguished Lectureship and Visiting Professor Kansai University, School of Medicine, Japan

1996 Distinguished Lectureship and Visiting Professor Baptist Memorial Hospital,

4 of 193 Prepared: October 27, 2015

Memphis, Tennessee

1996 Distinguished Lectureship and Visiting Professor Temple University, School of Medicine

1996 Distinguished Lectureship and Visiting Professor West Virginia, School of Medicine 1997 Distinguished Lectureship: Klinisch- German Society of Neuroradiologisches Symposium Neuroradiology

1997 Distinguished Lectureship and Visiting Professor University of Hamburg, School of Medicine, Germany

1997 Distinguished Lectureship and Visiting Professor Mayo Clinic &

1998 Distinguished Lectureship and Visiting Professor Indiana University, School of Medicine

1998 Distinguished Lectureship and Visiting Professor Wakayama University, School of Medicine, Japan

2000 Distinguished Lectureship and Visiting Professor Baylor University, School of Medicine 2002 Distinguished Lectureship: Beijing Neurological Chinese Neurosurgical Institute Society, Beijing, China 2000 Distinguished Lectureship and Visiting Professor: World Stroke Congress 4th World Stroke Congress Federation, Melbourne, Australia

2002 Distinguished Lectureship and Visiting Professor Beth Israel Medical Center, Boston, Massachusetts

2002 Distinguished Lectureship and Visiting Professor William Beaumont Medical Center, Royal Oak, Michigan 2002 Distinguished Lectureship and Visiting Professor: Singapore Endovascular Annual Pan-Asian Conference on Endovascular Radiology Society Therapeutics

2002 Distinguished Lectureship and Visiting Professor Hoag Memorial Hospital, Newport Beach, California

2002 Distinguished Lectureship and Visiting Professor Bangkok Society of Radiology

2002 Distinguished Lectureship and Visiting Professor Stanford University Medical Center 2002 Distinguished Lectureship and Visiting Professor: South America Stroke International Stroke Symposium Society, Buenos Aires, Argentina 2003 Distinguished Lectureship and Presidential Joint Section of Address Cerebrovascular Neurosurgery and the

5 of 193 Prepared: October 27, 2015

American Society of Interventional and Therapeutic Neuroradiology 2003 Distinguished Lectureship: National Scientific German Society of Symposium Neurology and . Baden-Baden, Germany

2003 Distinguished Lectureship and Visiting Professor University of Oxford, Medical Center, Oxford, England

2003 Distinguished Lectureship and Visiting Professor University of Heidelburg, School of Medicine, Germany

2003 Distinguished Lectureship and Visiting Professor Cleveland Clinic Medical Center

2003 Distinguished Lectureship and Visiting Professor North Shore Royal Hospital, School of Medicine, Sydney, Australia 2003 Distinguished Lectureship: National Scientific Korea Interventional Symposium Neuroradiology Society, Seoul, Korea

2003 Distinguished Lectureship and Visiting Professor St. Paul Medical Center, Minneapolis

2003 Distinguished Lectureship and Visiting Professor World Federation of Interventional and Therapeutic Neuroradiology, Recife, Brazil

2003 Distinguished Lectureship and Visiting Professor Wake Forest University, School of Medicine

2004 Distinguished Reviewer Award Journal of Vascular & Interventional Radiology 2004 Distinguished Lectureship and Visiting Professor: European Society of Annual Scientific Meeting Neurology, Madrid, Spain

2004 Distinguished Lectureship and Visiting Professor Tianjin University, School of Medicine, China

2004 Distinguished Lectureship and Visiting Professor Chongqing 4th Military Hospital and School of Medicine, China

2004 Distinguished Lectureship and Visiting Professor Seoul National University, School of Medicine, South Korea

2004 Distinguished Lectureship and Visiting Professor Australasian Society of

6 of 193 Prepared: October 27, 2015

Interventional Neuroradiology, Bangkok, Thailand

2005 Charles T. Dotter Memorial Lecture Award American Heart Association 2005 Distinguished Lectureship: The 6th International Japanese Congress of Congress on Minimally Invasive Neurosurgery Minimally Invasive Neurosurgery, Nagoya, Japan

2005 Distinguished Lectureship and Visiting Professor Shenyang University School of Medicine, China 2005 Distinguished Lectureship and Visiting Professor: South America Congress of Annual Scientific Meeting Neurosurgery, Lima, Peru

2005 Distinguished Lectureship and Visiting Professor Pan Pacific Interventional Neuroradiology Society, Hanoi, Vietnam

2006 Distinguished Lectureship and Visiting Professor Queen's Medical Center, Honolulu, Hawaii

2005 Distinguished Lectureship and Visiting Professor India-U.S. Science and Technology Forum, New Dehli, India

2006 Melvin Judkin's Memorial Award Lecture American Heart Association

2007 Elected Fellow Society of Interventional Radiololgy

2007 Donald Sterns Memorial Lecture In Radiology John Muir Medical Center, Concord, California 2007 Gainey Lecturer in Radiological Sciences: Mayo Clinic & Hospitals, Distinguished Visiting Professorship Rochester, Minnesota

2007 Distinguished Lectureship and Visiting Professor Tufts New-England Medical Center, Boston, Massachusetts

2007 Distinguished Lectureship and Visiting Professor St. Mary's Medical Center, Saginaw, Michigan

2008 Elected Fellow American Heart Association 2008 Distinguished Lectureship: 8th Annual Asia Pacific Congress of Congress Cardiovascular and Interventional Radiology, Kuala Lumpur, Malaysia 2008 Distinguished Lectureship: 6th World Stroke World Congress on Stroke, Congress Vienna, Austria

2009 Elected Fellow Society of Neuro

7 of 193 Prepared: October 27, 2015

Interventional Surgery

2009 Distinguished Lectureship and Visiting Professor Perth University, School of Medicine, Western Australia

2009 Distinguished Lectureship and Visiting Professor Asian Hospital Medical Center, School of Medicine, Manila, Phillipines 2010 Distinguished Lectureship: Neurosurgical Indonesia Congress of Symposium on Cerebrovascular Diseases Neurosurgery, Jakarta, Indonesia 2010 Distinguished Lectureship: Third International South America Congress of Congress of Neurology Neurology, Santiago, Chile 2011 Distinguished Lectureship: International Oriental Congress on Symposium on Cerebrovascular Disease Endovascular Neurosurgery, Shanghai, China 2011 Distinguished Lectureship: XXth World Congress World Congress of of Neurology Neurology, Marrakesh, Morocco

2012 The Best Doctors in America Fourth Edition Marquis Who's Who

2012 Who's Who in America Outstanding Marquis Who's Who

2012 America's Top Radiologists Research Council of America

2012 San Francisco Bay Area Best Doctors San Francisco Magazine

2012 America's Top Doctors Research Council of America 2012 Distinguished Lectureship: The 10th International Chinese Congress of Conference on Cerebovascular Surgery Neurosurgery and Neurology, Beijing, China 2012 Distinguished Lectureship: The 8th World Stroke World Congress on Stroke, Congress Brasilia, Brazil

2012 Top 1% of Physicians in Neurosciences in the U.S News & World Report United States

2014 Luminary Lectureship; Distinguished Professor Society of Neuro Interventional Surgery; Annual Scientific Meeting, Colorado Springs, Colorado

2015 Top Physicians in San Francisco San Francisco Magazine

2015 Who's Who In America 70th Platinum Edition

2016 Who's Who In Science and Engineering Marquis Science Edition

8 of 193 Prepared: October 27, 2015

KEYWORDS/AREAS OF INTEREST Interventional Neuroradiology Endovascular Neurosurgery Neuro Interventional Surgery Minimally Invasive Neurosurgery Neuro Interventional Radiology Endovascular Treatment of Interventional Treatment of Acute Ischemic Stroke Carotid Stenting Intracranial & Stenting Treatment of Intracranial Arterial Vasospasm

PROFESSIONAL ACTIVITIES CLINICAL

Dr. Randall Higashida has served as Chief of the UCSF Interventional Neuroradiology (INR) section since 1996, within the Department of Radiology. The INR section is composed of 5 full time faculty, 3 full time neuro-interventional fellows, and 7 diagnostic neuroradiology fellows per year. The INR service provides full-time coverage of 3 hospitals including UCSF Medical Center, San Francisco General Hospital, and the San Francisco Veterans Affairs Medical Center. In 2015, we will also provide coverage of the new Mission Bay Women's and Children's Hospital.

Dr. Higashida spends 40-50 hours per week involved in the clinical care of patients referred from the departments of neurosurgery, neurology, , and general medicine, who require either the diagnosis or the treatment of complex cerebrovascular disorders and/or abnormalities.

The INR service provides 24 hour/ 7 day per week coverage for UCSF in-patients and out- patients who are diagnosed with acute ischemic and/or hemorrhagic , vascular abnormalities of the brain, head, neck, and/or spine, hypervascular tumors, and traumatic vascular .

The INR service performs >1200 procedures per year, as well as consultations on both in- patients and out-patients, within the UCSF Neurosciences service line. We perform daily rounds on all patients, weekly conferences in conjunction with the stroke neurology, vascular neurosurgery, and neuro- services to discuss management of new cases, as well as monthly morbidity and mortality meetings.

The INR service provides full time coverage of the Northern California region for acute stroke patients who are diagnosed and require rapid interventional treatment within 6-8 hours from the onset of symptoms. UCSF is considered a tertiary acute stroke hospital for referrals of all patients with a subarachnoid or intracerebral hemorrhage, as well as a comprehensive stroke hospital which accepts emergency patients from surrounding emergency rooms. The INR staff have been an integral part of providing these services to the hospital for the past 27 years.

SUMMARY OF CLINICAL ACTIVITIES

9 of 193 Prepared: October 27, 2015

Dr. Randall Higashida was recruited by UCSF Medical Center in 1986, to organize and develop the specialty of Interventional Neurovascular Radiology (INR), within the departments of Radiology and Neurosurgery.

In the past, Dr. Higashida has spent considerable time and effort traveling to different medical centers in the United States and internationally to perform and teach interventional neurovascular procedures for critically ill patients. These patients were judged to be too sick for transfer by ambulance or air evacuation to UCSF and often presented with life threatening disorders without alternative treatments.

Currently, the referrals to UCSF Medical Center for treatment of complex cerebrovascular diseases, have increased to the point, where the INR group has become one of the busiest and most well recognized centers in the world.

Our section has pioneered the interventional treatment of ruptured and un-ruptured brain aneurysms by techniques, acute ischemic stroke by intra-arterial and mechanical thrombo-, treatment of complex dural arteriovenous fistula's by endovascular occlusion with liquid tissue adhesives, treatment of carotid by carotid artery stenting, schlerotherapy for facial vascular malformations, and the diagnosis and treatment of complex spinal cord vascular abnormalities.

Dr. Higashida's areas of clinical expertise include the treatment of intracranial cerebral aneurysms, acute ischemic stroke, management of arterial vasospasm, treatment of carotid atherosclerosis by stenting, and treatment of intracranial atherosclerosis by balloon angioplasty and stenting. Many of these minimally invasive brain therapy techniques have been pioneered by Dr. Higashida and the INR group, during his 28 years of service to the medical center.

PROFESSIONAL ORGANIZATIONS Memberships 1984 - present American Society of Neuroradiology - Senior Member; Past Member of the Executive Committee 1984 - 2000 American Medical Association 1984 - 2000 Radiological Society of North America 1984 - 2000 American Roentgen Ray Society 1984 - present Western Neuroradiological Society - Senior Member 1984 - 2000 American College of Radiology 1984 - 2000 California Radiological Society 1984 - 2000 California Medical Association 1984 - 1987 Los Angeles Radiological Society 1984 - 1987 Los Angeles Neuroradiological Society 1984 - 2000 Association of University Radiologists 1984 - 2000 San Francisco Medical Society

10 of 193 Prepared: October 27, 2015

1986 - 2004 San Francisco Radiological Society 1986 - present Joint Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and Congress of Neurosurgery: Past Member of the Executive Council 1986 - present World Federation of Interventional Neuroradiology - Senior Member 1986 - present American Stroke Association 1990 - present Society of Cardiovascular and Interventional Radiology/Society of Interventional Radiology: Fellow 2000 - present Society of Neuro Interventional Surgery (American Society of Interventional and Therapeutic Neuroradiology): Past President, Executive Committee, Senior Member, Fellow 2000 - present San Francisco Neurological Society 2000 - present American Heart Association; Executive Council; Fellow; Strategic Advisory Committee; Council on Cardiovascular Radiology and Interventions: Past Chairman; Neuro Radiology Committee: Past-Chair; Nominating Committee: Past Chair; 2000 - present Bay Area Stroke Society 2014 - present European Stroke Organization Advisory Council

Service to Professional Organizations 1991 - 1993 Society of Cardiovascular and Interventional Economic Affairs Committee Radiology 1991 - 1993 American Society of Neuroradiology Committee on Training Standards in Interventional Neuroradiology 1991 - 1993 National Registry for Carotid Angioplasty Steering Committee 1992 - 1993 Prolyse for Acute Cerebral Thromboembolism Executive Steering Committee 1993 - 1994 Joint Section of Cerebrovascular Neurosurgery, Executive Committee 1993 - 1994 First International Congress on Minimally Invasive Scientific Committee Neurosurgery 1993 - 1994 National Morbidity and Mortality Conference in Program Co-Chairman; Interventional Neuroradiology Scientific Committee 1993 - 1994 The Third International Symposium on Scientific Advisory Thrombolytic Therapy in Acute Ischemic Stroke. Committee Nara, Japan 1993 - 1994 Joint Council of the American Association of Cerebrovascular Neurological Surgeons and the Congress of Neurosurgery Task Force Neurosurgery Committee 1993 - 1994 Intra-Arterial Pro-Urokinase for Acute Middle Executive/Steering Cerebral Artery Stroke Multicenter Trial Committee

11 of 193 Prepared: October 27, 2015

1994 - 1995 Second International Congress on Minimally Neurosurgery Organizing Invasive Techniques in Neurosurgery and Committee Otolaryngology 1994 - 1996 Fourth International Symposium on Thrombolytic Scientific Advisory Therapy in Acute Ischemic Stroke Committee 1994 - 1996 International Congress on Interventional International Advisory Neuroradiology and Intravascular Neurosurgery Committee 1994 - 1996 Joint Section on Cerebrovascular Surgery Scientific Advisory Committee; Organizing Committee for First Annual Meeting 1994 - 1996 Society of Cardiovascular and Interventional ICD 9 Coding Committee Radiology 1994 - 1996 American Society of Interventional and Executive Committee; Therapeutic Neuroradiology Chairman, Intersociety Liaison Committee; Committee on Medical Devices: Cyanoacrylates 1995 - 1996 American College of Radiology Subcommitte on Coding & Interventional Neuroradiology 1995 - 1996 Society of Cardiovascular and Interventional Physician Reimbursement Radiology Committee 1995 - 1996 American Society of Neuroradiology Program Committee: Annual Scientific Sessions 1995 - 1996 Intersociety Liaison Committee for Neuroscience's Program Committee for Annual Scientific Meetings 1995 - 1996 Carotid Supported Angioplasty Registry Executive Steering North American Trial Committee 1995 - 1996 American Heart Association Emergency Management and Critical Care of Stroke Committee 1995 - 1997 Abbott Laboratories Executive Advisory Board Executive Advisory Board for the Phase III North American Proact Trial 1996 - 1997 American Heart Association Stroke Council Research Funding Committee 1996 - 1997 American Heart Association Prevention IV Prevention and Rehabilitation Conference of Stroke Committee 2014 - 2015 American College of Abstract Reviewer for Annual Scientific Sessions 1996 - 1997 Joint Section on Cerebrovascular Surgery Executive Council; Co-Chair: Scientific Program Committee; Abstract and

12 of 193 Prepared: October 27, 2015

Organizing Committee 1996 - 1997 Cerebrovascular Societies Liaison Committee Organizing Committee 1996 - 1997 Carotid Artery Stenting vs. Trial Executive Committee 1996 - 1997 American Society of Interventional and Executive Committee Therapeutic Neuroradiology 1996 - 1997 American Society of Neuroradiology Education Committee; Coding and Reimbursement Committee 1997 - 1998 Joint Section on Cerebrovascular Surgery Executive Council; Finance Committee; Alfred J. Lussenhop Lectureship Awards Committee; Program Committee for Annual Scientific Meeting 1997 - 1998 Society of Cardiovascular and Interventional Physician Reimbursement Radiology Committee 1997 - 1998 American Society of Neuroradiology FDA Liaison Committee 1998 - 1999 Joint Section of Cerebrovascular Surgery Endovascular Fellowship Grant Program Committee 1998 - 1999 5th International Symposium on Thrombolytic Scientific Advisory Therapy in Acute Ischemic Stroke Committee 1998 - 1999 Society of Cardiovascular and Interventional Physician Reimbursement Radiology Committee 1998 - 1999 PROACT II Clinical Trials Group Publications Committee 1998 - 1999 American Society of Neuroradiology Executive Committee; Education Committee Chair; Program Committee; Task Force to Reassess the Strategic Plan of the ASNR; Clinical Practices Committee; Commercial Relations Committee 1998 - 2000 Joint Conference of the American Society of Program Chairman Interventional and Therapeutic Neuroradiology and the Joint Section of Cerebrovascular Surgery 1999 - 2000 American Heart Association Scientific Publications Committee; Guidelines Practice Committee for Stroke; Clinical Practice Guidelines for Interventional Neuroradiology Procedures 1999 - 2000 American Society of Neuroradiology Intersociety Liaison Advisory Committee; Committee on Commercial Relations;

13 of 193 Prepared: October 27, 2015

Reimbursement Panel to CPT for Carotid Artery Stenting; Intersociety Liaison Advisory Group to American Association of Neurological Surgeons 1999 - 2000 Cerebrovascular Imaging and Interventions Chairman Council on Cardiovascular Radiology, American Heart Association 1999 - 2000 Society of Cardiovascular and Interventional FDA Neurological Devices Radiology Advisory Committee 1999 - 2000 American Heart Association: Guidelines and Chair, Writing Task Force Standards For Endovascular Treatment of Intracranial Aneurysms 1999 - 2001 Co-Chairman Scientific and Executive Committee Annual Scientific Meeting: of the American Society of Interventional & Chair Therapeutic Neuroradiology and the Joint Section of Cerebrovascular Surgery 1999 - 2001 Society of Cardiovascular and Interventional Economics Committee Radiology 1999 - 2001 TIME AngioJet Trial in Ischemic Stroke Executive Steering Committee 1999 - 2002 American Heart Association Cardiovascular Radiology Council: Executive Committee 1999 - 2003 Maveric Carotid Artery Stent Trial: Phase 2/3 National Principal Investigator 2000 - 2001 Embolo Therapy Workshop Advisory Committee 2000 - 2001 American Society of Interventional and Vice President; Chair: Therapeutic Neuroradiology Technology Assessment Committee; Economics Committee; President Elect; Executive Committee 2000 - 2001 American Heart Association: "Guidelines and Writing Group Task Force Standards for Imaging of Ischemic Stroke " and Committee "Guidelines and Standards for of Stroke" 2000 - 2001 American Society of Neuroradiology Coding and Reimbursement Committee 2000 - 2002 Society of Cardiovascular and Interventional Technology Assessment Radiology Committee 2000 - 2001 Joint Section of Cerebrovascular Neurosurgery Scientific Program International Conference Committee 2000 - 2001 World Federation of Interventional and Therapeutic International Advisory

14 of 193 Prepared: October 27, 2015

Neuroradiology Committee to the 6th World Congress 2000 - 2002 National Stroke Association Expert Stroke Panel Executive Task Force Committee 2001 - 2002 American Society of Neuroradiology FDA Neurological Devices Committee 2001 - 2002 National Institutes of Health NIH Neurological Division: Stroke Progress Group Executive Committee 2001 - 2002 American Heart Association, 70th Annual John J. Stroke Program Planning Sampson Symposium Committee 2001 - 2002 American Society of Interventional & Therapeutic Chairman: Annual Scientific Neuroradiology & Joint Section of Cerebrovascular Meeting Neurosurgery Society 2001 - 2002 American Society of Neuroradiology Coding and Reimbursement Subcommittee of Clinical Practice Committee; Clinical Outcomes Committee; Membership Committee 2001 - 2002 6th Joint Session of the American Society of Executive Planning Interventional and Therapeutic Neuroradiology and Committee Joint Section of Cerebrovascular Neurosurgery 2001 - 2002 The 7th International Symposium on Thrombolysis Organizing Committee and Acute Stroke Therapy, Lyon, France 2002 - 2003 Cabernet Carotid Artery Stent Trial Data Safety and Monitoring Board 2002 - 2003 American Society of Neuroradiology Executive Committee; Clinical Practices Committee; Coding and Reimbursement Committee; Chair: Membership Committee; Clinical Outcomes Research Committee; FDA Liaison Committee 2002 - 2005 Saint Louis Hospital, Bangkok Thailand Medical Advisory Board 2002 - 2003 7th Congress of the World Federation of International Advisory Interventional & Therapeutic Neuroradiology Committee 2002 - 2003 American Heart Association Student Scholarship Committee In Cardiovascular Disease and Stroke; Melvin Judkin's Awards Committee 2002 - 2003 American Society of Interventional & Therapeutic FDA Advisory Committee Neuroradiology 2003 - 2004 American Society of Neuroradiology Committee for Evidence

15 of 193 Prepared: October 27, 2015

Based Medicine; Coding & Reimbursement Committee 2003 - 2005 American Society of Interventional and Executive Operations Therapeutic Neuroradiology Committee 2003 - 2005 American Heart Association Council on Vice Chairman: Cardiovascular Radiology and Interventions Interventional Neuroradiology Committee 2002 - 2004 American Society of Interventional & Therapeutic Executive Council Neuroradiology & the Joint Section of Cerebrovascular Neurosurgery 2003 - 2004 Society of Interventional Radiology and American Co-Chairman Society of Interventional and Therapeutic Neuroradiology Research Conference: Stroke Interventions 2003 - 2004 8th International Symposium on Thrombolysis & Scientific Advisory Board Acute Stroke 2003 - 2004 Neuro Critical Care Society Board of Directors 2004 - 2005 Prolyse in Acute Cerebral Thromboembolism Executive Steering Phase III Trial Committee 2004 - 2005 6th International Congress on Minimally Invasive International Advisory Neurosurgery Scientific Board 2004 - 2005 American Society of Neuroradiology Coding & Reimbursement Committee; Committee for Evidence Based Medicine 2004 - 2005 American Society of Interventional and Committee on Carotid Therapeutic Neuroradiology and Society of Stenting and Stroke Task Interventional Radiology Force 2004 - 2005 American Heart Association/American Stroke Strategic Planning Expert Association Panel for Stroke Committee; Writing Group Committee on: Guidelines for Acute Ischemic Stroke 2004 - 2006 Actelion Vasospasm Therapy Trial Scientific Advisory Committee 2004 - 2007 Maveric Phase III Trial: Carotid Artery Stenting National Principal Investigator 2004 - 2008 MERCI Trial: The Role of Mechanical Steering Committee Thrombectomy to Treat Acute Ischemic Stroke 2005 - 2006 American Heart Association Science Advisory & Coordinating Committee; Chair: Cardiovascular Radiology Council 2005 - 2006 American Society of Neuroradiology Coding & Reimbursement,

16 of 193 Prepared: October 27, 2015

Subcommittee on Clinical Practice 2005 - 2006 12th Asian Australasian Congress of Neurological International Advisory Board Surgeons & World Federation of Neurosurgical Societies 2006 - 2007 9th World Federation of Interventional and International Advisory Board Therapeutic Neuroradiology, Beijing, China 2009 - 2010 CARNEROS Trial: The Role of Intra-Arterial Executive Steering Alfimiprase To Treat Acute Ischemic Stroke Committee 2007 - 2008 American Heart Association Writing Group Committee for Acute Ischemic Stroke Guidelines 2007 - 2008 Xth Annual International Symposium on International Advisory Board Thrombolysis and Acute Ischemic Stroke Budapest, Hungary 2007 - 2009 American Heart Association, Cardiovascular Chair, Nominating Radiology & Intervention Council Committee 2007 - 2010 NIH Funded Trial on Intracranial Atherosclerosis Executive Steering Trial to Compare Best Medical Therapy vs. Committee Intracranial Stenting 2008 - 2009 World Federation Of Interventional & Therapeutic International Advisory Neuroradiology Committee 2008 - 2012 Randomized Trial of Endovascular Treatment of Steering Committee Acute Ischemic Stroke vs. Medical Management (RETRIEVE) 2010 - 2011 XXth World Congress on Neurology, Marrakesh, International Organizing Morocco Committee 2010 - 2011 The 8th International Interdisciplinary International Advisory Cerebrovascular Symposium Meeting, Shanghai, Committee China 2011 - 2014 Massachusetts General Hospital Peer Review Academic Committee 2012 - 2013 Maui Memorial Medical Center Peer Review Committee for Radiological Sciences & Interventional Neuroradiology Services 2012 - 2014 American Medical Foundation Peer Review Committee 2013 - 2014 XII International Symposium on Thrombolytic International Stroke Advisory Therapy in Acute Ischemic Stroke, Heidelberg, Council Germany 2013 - 2014 American College of Cardiology, 63rd Annual Abstract Reviewer Scientific Sessions 2013 - 2014 American Society of Neuroradiology, Annual Abstract Reviewer

17 of 193 Prepared: October 27, 2015

Scientific Sessions 2013 - 2014 International Neurological Symposium, Santiago, International Advisory Chile Council 2014 - 2015 American Heart Association Peer Review Committee for Grant Support 2014 - 2015 European Stroke Organization, Glasgow, Scientific Advisory Board Scotland 2014 - 2015 American College of Cardiology, Annual Scientific Abstract Reviewer Sessions 2015 - 2016 World Stroke Organization, Annual Scientific Abstract Reviewer Sessions 2015 - 2016 European Stroke Organization Scientific Advisory Council

SERVICE TO PROFESSIONAL PUBLICATIONS 1994 - 2010 Journal of Endovascular Surgery, Editorial Board 2003 - 2010 American Journal of Neuroradiology, Manuscript Reviewer, Editorial Board 1994 - 2010 Journal of the Hong Kong Medical Association, Manuscript Reviewer 1994 - present International Journal for Minimally Invasive Neurosurgery, Editorial Board 1998 - 2008 The Stroke Interventionalist: Editorial Board 1998 - 2011 Neurosurgery- Manuscript Reviewer, Editorial Board 1999 - 2010 American Heart Association Newsletter, Editorial Board 1999 - present Journal of Neuro Imaging: Editorial Board 2000 - present Catheterization and Cardiovascular Interventions: Manuscript Reviewer, Editorial Board 2000 - present Stroke, Manuscript Reviewer 2001 - 2008 Journal of Vascular and Interventional Radiology, Editorial Board 2000 - present Radiology, Manuscript Reviewer 2000 - present Surgical Neurology, Manuscript Reviewer 2003 - 2007 Cerebrovascular Diseases, Manuscript Reviewer, Editorial Board 2002 - present Neurology, Manuscript Reviewer 2002 - present Journal of the American Medical Association, Manuscript Reviewer 2002 - present Cochrane Stroke Group, Manuscript Reviewer 2002 - present BioMedical Central, Manuscript Reviewer 2003 - present Techniques in Vascular and Interventional Radiology, Editorial Board 2003 - present QJM: An International Journal of Medicine, Manuscript Reviewer 2004 - present Health Policy Journal, Manuscript Reviewer 2005 - present New England Journal Of Medicine: Manuscript Reviewer

18 of 193 Prepared: October 27, 2015

2005 - present International Journal of Stroke, Editorial Board 2006 - present Expert Review of Neurotherapeutics, Manuscript Reviewer 2009 - present World Journal of Radiology: Editorial Board 2012 - present Interventional Neurology, Associate Editor; Editorial Board 2012 - present ISRN Minimally Invasive Surgery, Editorial Board 2013 - present Advances in Vascular Medicine, Editorial Board 2014 - present Edorum Journal of Radiology, Editorial Board 2014 - present Austin Journal of Cerebrovascular Disease & Stroke, Associate Editorial Board 2015 - present Journal of Advances in Radiology and , Editorial Board 2015 - present Journal of Neurointerventional Surgery, Manuscript Reviewer

INVITED PRESENTATIONS INTERNATIONAL 1985 "Intravascular surgery for treatment of intracranial Visiting Professor aneurysms", National Stroke Institute, Akita, Japan. 1985 "Intravascular of intracranial aneurysms", Visiting Professor Kyorin University School of Medicine, Department of Neurosurgery, Tokyo, Japan. 1986 "Interventional neurovascular radiology", European Stroke Symposium, Paris, France. 1987 "Interventional neurovascular techniques for treatment of Visiting Professor aneurysms and vascular lesions", Kyung Hee University- Medical Center, Seoul, Korea. 1988 "The future of interventional neuroradiology"; "Percutaneous transluminal angioplasty of brachiocephalic vessels for atherosclerotic disease"; "Treatment of intracranial aneurysms by interventional neurovascular techniques"; "Transluminal angioplasty of intracranial arterial vasospasm"; "Techniques for use of valved detachable balloons, newer microcatheters and HEMA"; "Intravascular embolization of cerebral arteriovenous malformations", Second International Course in Interventional Neuroradiology, Paris, France. 1988 "Interventional neurovascular techniques for treatment of Visiting Professor aneurysms", Society of British Neurological Surgeons and British Society of Neuroradiology, Glasgow, Scotland. 1989 "Interventional neurovascular techniques for treatment of brain arterial-venous malformations"; "Treatment of intracranial aneurysms and arterial vasospasm by interventional neurovascular techniques", The Second International Workshop on Intracranial Aneurysms, Nagoya, Japan.

19 of 193 Prepared: October 27, 2015

1990 "Percutaneous transluminal angioplasty for cerebrovascular disorders." International Symposium for Cerebral Vasospasm. Sixth Annual Meeting. Kyoto, Japan. 1991 "Transluminal balloon angioplasty for intracranial arterial vasospasm."; "Endovascular treatment of intracranial aneurysms: Experience in 270 cases." Second International Symposium on Interventional Neuroradiology. Mexico City, Mexico. 1991 "Interventional neurovascular treatment of intracranial Visiting Professor aneurysms"; "Intravascular treatment of cerebral aneurysms in the posterior circulation". The 50th Annual Meeting of The Japan Neurosurgical Society. Kyoto, Japan. 1992 "Percutaneous transluminal angioplasty for Visiting Professor cerebrovascular atherosclerotic disease." ; "Transluminal angioplasty for intracranial arterial vasospasm in impending stroke." Twenty First International Conference on Surgery for Cerebral Stroke. Nagoya, Japan. 1992 "Interventional treatment of complex vascular malformations"; "Interventional approach to treatment of intracranial aneurysms." Interventional Radiology/Neuroradiology Conference. Bermuda. 1992 "Interventional neurovascular treatment for cerebral Visiting Professor stroke." The 17th Annual Meeting of the Japanese Stroke Congress. Nagoya, Japan. 1992 "Treatment of Cerebrovascular Diseases by Transluminal Angioplasty." Second World Congress of Stroke. International Stroke Society. Washington, D.C. 1992 "Percutaneous transluminal cerebral angioplasty."; Visiting Professor "Interventional treatment for stroke."; "Endovascular treatment of Intracranial Aneurysms with the GDC electrolytic coil." Society of British Neuroradiology. Distinguished Professor Lectureship. London, England. 1992 "Interventional treatment of carotid cavernous sinus Visiting Professor fistulas."; "Endovascular treatment of intracranial aneurysms and arteriovenous malformations". Scandinavian Neurosurgical Society. Tampare, Finland. 1992 "Recent advancements in the field of endovascular Visiting Professor neurosurgery". The 14th Annual Meeting of the TOKAI Conference for post-graduate Neurosurgical Education. Nagoya, Japan. 1992 "Interventional approach to lesions of the Cavernous Sinus." First International Skull Base Congress. Hannover, Germany. 1992 "Advances in the field of interventional neurovascular Visiting Professor

20 of 193 Prepared: October 27, 2015

radiology." Stroke Symposium, Europe. Rodin, Netherlands. 1993 "Endovascular Neurosurgery for treatment of Cerebral Visiting Professor Atherosclerotic Diseases."; "Endovascular Neurosurgery for treatment of Intracranial Aneurysms." First International Congress on Minimal Invasive Techniques in Neurosurgery. Wiesbaden, Germany. 1993 "Recent advances in neurovascular intervention." Clinical Visiting Professor Applications of New Imaging Techniques. Hong Kong Baptist Hospital. 30th Anniversary Symposium. Hong Kong. 1993 "Optimal techniques in Interventional Neurovascular Visiting Professor Radiology". Stroke Medical Symposium. Best, Netherlands. 1993 "Radiological techniques in thrombolysis". International Investigators Meeting for Acute Stroke with Intra Arterial Thrombolysis. Chicago, Illinois. 1993 "Advances in endovascular treatment of intracranial Visiting Professor aneurysms, angioplasty, and thrombolysis". Hong Kong College of Radiologists and Neurological Surgeons. China. 1994 "Endovascular treatment of Skull Base Lesions: Arteriovenous Fistulas and Malformations". International Symposium on Skull Base Surgery. Orlando, Florida. 1994 "Neuroradiological techniques in cerebral Visiting Professor for stroke: Current Controversies" Third International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke. Nara, Japan. 1994 "Endovascular management of complex cerebrovascular disorders." American Association of Neurological Surgeons. Annual Scientific Meeting. San Diego, California. 1994 "Interventional neurovascular treatment of aneurysms, Visiting Professor arteriovenous malformations, and fistulas."; "Endovascular neurosurgery advances in the past decade". Niigata Neurological Institute. Niigata, Japan. 1994 "Recent advances in cerebral angioplasty and Visiting Professor thrombolysis." Society of European Neuroradiology. Nancy, France. 1994 "Interventional Neuroradiology". International Stroke Visiting Professor Symposium. Rodin, Netherlands. 1994 "Advances in Interventional Neuroradiology: Future Visiting Professor Perspectives". The XV International Radiologicum Symposium. Kumamoto, Japan. 1994 "Cerebral fibrinolysis." ; "Interventional treatment of post- Visiting Professor

21 of 193 Prepared: October 27, 2015

traumatic fistulas."; "Intracerebral angioplasty for ."; "Cerebral angioplasty of the brachiocephalic vessels." Practical Interventional Neuroradiology: State of the Art. Buenos Aires, Argentina. 1994 "Interventional Neuroradiology: State of the Art Therapy." Visiting Professor Stroke Symposium, Europe. Brussels, Belgium. 1994 "Endovascular treatment of arteriovenous malformations, Visiting Professor fistulas, and traumatic vascular lesions." ; "Technical advances in Interventional Neurovascular Radiology: Aneurysms, Angioplasty, Thrombolysis." Akita Stroke Institute. Akita, Japan. 1994 "Interventional Neuroradiology and applications to Visiting Professor Interventional Magnetic Resonance ." Medical Imaging Symposium. Einthoven, Netherlands. 1994 "Cerebral percutaneous transluminal angioplasty." Third Visiting Professor International Congress on Stroke. Buenos Aires, Argentina. 1994 "Recent advances in endovascular neurosurgery." Tokyo Visiting Professor Research Symposium. Tokyo, Japan. 1994 "Cerebral percutaneous transluminal angioplasty." The Visiting Professor Dutch Society of Angiology. Annual Scientific Assembly. Scheningen, Netherlands. 1994 "Cerebral transluminal angioplasty for atherosclerosis." Visiting Professor Endovascular Neurosurgical Society of Japan. National Scientific Session. Niigata, Japan. 1995 "Cerebral percutaneous transluminal angioplasty."; "Endovascular treatment of acute traumatic injuries to the head and neck." International Symposium on Peripheral Vascular Interventions. Miami, Florida. 1995 "Recent advances in Interventional Neuroradiology: Visiting Professor Special Lecture."; "Interventional Treatment of Intracranial Aneurysms". The 24th Japan Neuroradiological Congress. Tokyo, Japan. 1995 "Endovascular Treatment of Acute Vascular Injuries to the Head and Neck." Eighth International Congress on Endovascular Surgery. Scottsdale, Arizona. 1995 "Interventional neuroradiology in acute stroke therapy: Visiting Professor Cerebral angioplasty and thrombolysis."; "Recent advances in Interventional Neuroradiology: , Trauma, Vascular Malformations." The Second Asian- Pacific Congress of Cardiovascular and Interventional Radiology. Tokyo, Japan. 1995 "Endovascular therapeutic procedures in minimally Visiting Professor invasive therapy." Second International Congress on Minimally Invasive Therapy in Neurosurgery. Pittsburgh,

22 of 193 Prepared: October 27, 2015

Pennsylvania. 1995 "Thrombolytic therapy in acute stroke.". The International Visiting Professor Congress on Interventional Neuroradiology and Intravascular Surgery. Kyoto, Japan. 1995 "Interventional neuroradiological treatment of acute stroke: Visiting Professor Cerebral angioplasty and thrombolysis."; "Interventional neuroradiological treatment of intracranial aneurysms." The Centennial Celebration of the Hong Kong College of Radiology. Hong Kong. 1995 "Complications of endovascular neurosurgery." Japanese Visiting Professor Neurosurgery Society. Tokyo, Japan. 1995 "Advances in Interventional Neuroradiology: Aneurysms, Visiting Professor Stroke, Thrombolysis." Radiology, Neurology, Neurosurgery Grand Rounds. The Veterans Memorial Hospital. Taipei, Taiwan. 1995 "Recent developments and advances in endovascular Visiting Professor neurosurgery." Neurosurgery and Neuroradiology Society. Kansai Medical Center. Osaka, Japan. 1996 "Cerebral angioplasty and thrombolysis in the cerebral circulation." International Congress IX. International Society of Endovascular Surgery. Scottsdale, Arizona. 1996 "Neuroradiology techniques for cerebral angioplasty and stenting." Transcatheter Cardiovascular Therapeutics, 8th International Annual Symposium. Washington, D.C. 1996 "An interventional neuroradiology perspective of cerebral angioplasty." The North American Symptomatic Trial Canadian Working Group. London, Ontario Canada. 1996 "Direct intra-arterial thrombolytic therapy in acute ischemic Visiting Professor stroke: Technique and results." 4th International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke. Copenhagen, Netherlands. 1996 "Endovascular treatment of intracranial arterial Visiting Professor aneurysms."; "Current Status of Intra-arterial Thrombolysis for Acute Stroke." International Stroke Therapy Prevention Conference. Heidelberg, Germany. 1997 "Management of traumatic lesions of the head and neck."; "Intra-arterial thrombolysis for Acute Stroke: Current Status of the PROACT Trial." Ninth Annual International Symposium on Vascular Diagnosis and Intervention. Miami, Florida. 1997 "Acute endovascular treatment of symptomatic Visiting Professor aneurysms." Klinisch-Neuroradiologisches Symposium. Hamburg, Germany. 1997 "Endovascular Treatment of Intracranial Aneurysms".

23 of 193 Prepared: October 27, 2015

International Congress X. International Society of Endovascular Surgery. Scottsdale, Arizona. 1997 "Angioplasty of the carotid artery: Are optional or a Visiting Professor new standard?" Neuroradiologic Aktuell Symposium. Hamburg, Germany. 1997 "Minimally invasive treatment for acute cerebral ". Visiting Professor 9th International Meeting of the Society for Minimally Invasive Therapy. Kyoto, Japan. 1997 "Endovascular therapy for intracranial and extracranial atherosclerosis." North American Stroke Meeting. Montreal, Canada. 1997 "Intracranial Cerebral Revascularization Techniques." ; Visiting Professor "Complications of Neurointerventional Cerebral Stenting Procedures."; "Complications of Neurointerventional Cerebral Aneurysm Procedures." Second Annual Global Revascularization Complications Conference. New York, New York. 1998 "Intra-arterial thrombolysis for stroke: Current status and future directions." American Heart Association 23rd International Joint Conference on Stroke and Cerebral Circulation. Orlando, Florida. 1998 "Endovascular stenting for Carotid ."; Visiting Professor "Cerebrovascular Stenting for Atherosclerosis, Dissection, and Traumatic Vascular Lesions, of the Head and Neck". International Symposium on Metallic Stents and Grafts. Nara, Japan. 1998 "Carotid and cerebral angioplasty and stenting." Seoul Visiting Professor National University Medical Center. Seoul, Korea. 1998 "Cerebral angioplasty and stenting for cerebrovascular Visiting Professor disease". Japan Endovascular Neurosurgery Symposium. Wakayama, Japan. 1998 "Interventional treatment for acute cerebral ischemia: Visiting Professor Cerebral thrombolysis and angioplasty"; "Endovascular approach to treatment of intracranial aneurysms". The Annual Scientific Meeting of the Japanese Congress of Neurosurgery. Sapporo, Japan. 1998 "Interventional techniques in acute stroke intervention." Visiting Professor Kyung Hee University Medical Center. Seoul, Korea. 1999 "A practical approach to acute stroke fibrinolytic therapy." International Society for Carotid Artery Therapy. Second Annual Meeting. Washington, DC. 2000 "Thrombolytic therapy for Acute Ischemic Stroke". Visiting Professor Japanese Stroke Society Scientific Session. Tokyo, Japan. 2000 "Stroke Therapy Advances In Imaging"; "Acute

24 of 193 Prepared: October 27, 2015

Interventions in Thrombolytic Therapy for Stroke"; "Acute Interventions in Thrombolytic Therapy for Stroke"; "Interventional Perspective of Carotid Artery Stenting and Angioplasty". International Stroke and Heart Disease Conference. Honolulu, Hawaii. 2000 "Endovascular therapy in Acute Cerebral Ischemia". Visiting Professor International Symposium on Brain Research. Pittsburgh, Pennsylvania. 2000 "Prospective Payment System for Reimbursement". Japan Visiting Professor Neurology Society Annual Meeting. Tokyo, Japan. 2000 "Complications of Carotid Artery Stenting and Cerebral Aneurysm Therapy." Global Complications Meeting, Jackson, Wyoming. 2000 "Intra-Arterial Thrombolytic Therapy in Acute Ischemic Visiting Professor Stroke". International Symposium on Thrombolyisis and Fibrinolytic Therapy. Hamematsu, Japan. 2000 "Carotid artery stenting techniques". Japan Visiting Professor Neurovascular Symposium. Tokyo, Japan. 2000 "Endovascular Management of Dural AVF's: Efficacy, Morbidity, and Mortality."; "Cerebral AVM's"; "Intracranial Angiogplasty & Stenting"; "Treatment of Cerebral Ischemia". Endovascular Neuroradiology International Workshop and Live Cases." Houston, Texas. 2000 "Endovascular Therapy New Interventions"; "Intracranial Visiting Professor Angioplasty and Stenting for Atherosclerosis." ; "Carotid Artery Angioplasty and Stenting." ; "Intra-Arterial Thrombolytic Therapy in Acute Stroke." International Symposium of Stroke. Rosario, Argentina. 2000 "The Prolyse in Acute Cerebral Thromboembolism Trial". Visiting Professor The 4th World Stroke Congress. Melbourne, Australia. 2000 "Intra-arterial thrombolysis in acute ischemic stroke". The Visiting Professor 6th International Symposium on Acute Stroke and Thrombolytic Therapy. Hamilton Island, Great Barrier Reef. Australia. 2000 "Interventional Treatment of Acute Ischemic Stroke: The Visiting Professor Proact II Study and ". International Symposium on Imaging of Acute Stroke. Giessen, Germany. 2001 "Management of Cerebral Ischemia". International Meeting of the Cerebrovascular Neurosurgical Society and the American Society of Interventional and Therapeutic Neuroradiology. Waikoloa, Hawaii. 2001 "Complications of Intracranial Cerebral Stenting". Global Morbidity and Mortality Conference. Jackson Hole, Wyoming.

25 of 193 Prepared: October 27, 2015

2001 "Cerebral Thrombolysis for Acute Ischemic Stroke"; Visiting Professor "Cerebral Thrombolysis for Acute Ischemic Stroke"; "Carotid Artery Stenting: Indications, Techniques, Results". International Symposium for Oriental Congress on Endovascular Neurosurgery. Shanghai, China. 2001 "Carotid Artery Stenting and Angioplasty". American Heart Association 51st Annual Scientific Meeting. Anaheim, California. 2001 "Endovascular complications associated with Therapy". Neuro Endovascular Morbidity and Mortality Conference. Jackson, Wyoming. 2001 "Intracranial Angioplasty and Stenting for Acute Ischemic Visiting Professor Stroke"; "Interventional Approach to Treatment of Carotid Atherosclerosis"; "Interventional Approach to Treatment of Acute Ischemic Stroke". Hong Kong Symposium on Stroke Prevention and Therapy. Hong Kong. 2002 "Interventional Treatment for Intracranial Atherosclerotic Visiting Professor Disease". Singapore Radiological Society. Singapore. 2002 "Current Status of Carotid Artery Stenting in North Visiting Professor America". Bangkok Radiological Symposium. Bangkok, Thailand. 2002 "Economic Considerations of Carotid Artery Stenting"; Visiting Professor "Stenting and Angioplasty for Intracranial Atherosclerosis"; "Current Carotid Artery Stent Trials". Annual Scientific Symposium of the Singapore LIVE Interventional Course. Singapore. 2002 "Interventional MRI/MRA in Neurovascular Applications"; "Neuro Interventional Techniques for Chronic ". 2nd International Symposium on CT/MR Imaging. San Francisco, California. 2002 "Intracranial angioplasty and stenting for acute ischemic Visiting Professor stroke". 7th International Symposium on thrombolysis and Acute Stroke Therapy. Lyon, France. 2002 "Carotid Artery Stenting and Angioplasty"; "Intra-Arterial Visiting Professor Cerebral Thrombolysis in Acute Ischemic Stroke"; "Endovascular Approach to Cerebral Arteriovenous Malformations"; "Interventional and Surgical Treatment for Ruptured and Unruptured Cerebral Aneurysms". International Stroke Symposium. Buenos Aires, Argentina. 2002 "Interventional Approach to Clot Lyses". International Visiting Professor Stroke Meeting. Annual Scientific Meeting of the National Stroke Association. Camino Real, Mexico City. 2002 "Advances in Interventional MRI, MRA, and Diagnostic Angiography". Live Interventional Neuroradiology Congress. Houston, Texas.

26 of 193 Prepared: October 27, 2015

2002 "Advances in the Endovascular Treatment of Carotid Visiting Professor Artery Disease"; "Advances in the Endovascular Treatment of Acute Ischemic Stroke: Intracranial Atherosclerosis". Beijing Neurological Institute. Beijing, China. 2002 "Advances in the Endovascular Treatment of Acute Visiting Professor Ischemic Stroke: Intracranial Atherosclerosis"; "Advances in the Endovascular Treatment of Intracranial Atherosclerotic Disease"; "Advances in the Endovascular Treatment of Intracranial Cerebral Aneurysms". Shanghai Neurological Institute. Shanghai, China. 2002 "Intracranial Angioplasty and Stenting: Techniques and Visiting Professor Results"; "Endovascular Treatment of Acute Ischemic Stroke: Cerebral Thrombolysis"; "Cerebral Aneurysm Therapy: Surgical vs. Endovascular Results in Unruptured Aneurysms"; "Endovascular Treatment of Cerebral Aneurysms: Techniques and Advances". The Brazilian Society of Endovascular Surgery and Interventional Radiology. Brazil, South America. 2002 "Endovascular Approach to Acute Ischemic Stroke"; Visiting Professor "Interventional Treatment of Intracranial Atherosclerosis". Hong Kong Stroke Symposium. Hong Kong. 2002 "Endovascular Treatment of Ruptured Intracranial Visiting Professor Cerebral Aneurysms"; "Interventional Treatment of Acute Ischemic Stroke and Thrombolytic Therapy."; "Endovascular Treatment of Ruptured Intracranial Cerebral Aneurysms"; "Endovascular Approach to Carotid Artery Stenting". Singapore Stroke Symposium Conference. Singapore. 2003 "Interventional Treatment of Cerebral Aneurysms"; Visiting Professor "Interventional Treatment of Acute Stroke"; "Carotid Artery Angioplasty and Stenting"; "Intracranial Stenting for Cerebral Atherosclerosis". Hong Kong Surgical Symposium. Hong Kong. 2003 "Endovascular Therapy of Ruptured Brain Aneurysms". Visiting Professor Shanghai Surgical Symposium. Shanghai, China. 2003 "Recent Advances in Acute Stroke Treatment". International Symposium on Endovascular Therapy. Miami, Florida. 2003 "Endovascular Approach to Intracranial Cerebral Atherosclerosis". Scientific Session of the 4th Annual Pan Pacific Asian Neurosurgical Congress. Honolulu, Hawaii. 2003 "Intracranial Angioplasty and Stenting For Acute Stroke". Visiting Professor International Symposium on Stroke. Tokyo, Japan. 2003 "Endovascular Treatment of Intracranial Atherosclerotic Visiting Professor Disease". Japanese Endovascular Interventions Symposium. Nagoya Japan.

27 of 193 Prepared: October 27, 2015

2003 "Intracranial Atherosclerosis: Endovascular Therapy". Visiting Professor Taiwan Cerebrovascular Symposium. Taiwan, China. 2003 "Detachable Coil Embolization of Cerebral Aneurysms". Visiting Professor Shanghai Medical Symposium. Shanghai, China. 2003 "Cerebral Aneurysms: Use of New Devices and Visiting Professor Techniques". Beijing Medical College: Neurosurgical Forum. Beijing, China. 2003 "Advances in Endovascular Coiling of Cerebral Visiting Professor Aneurysms". Taipei Stroke Congress. Taipei, Taiwan. 2003 "Recent Advances in the Diagnostic and Interventional Visiting Professor Approach to Acute Stroke". German Society of Neurology and Psychiatry. Annual Scientific Symposium. Baden- Baden, Germany. 2003 "Advances in the Endovascular Treatment of Cerebral Visiting Professor Aneurysms and Carotid Artery Stenting". Neurology, Neuroradiology, Neurosurgery Symposium. Heidelberg University, Heidelberg, Germany. 2003 "Complications Associated with Intracranial Aneurysm Therapy". Global Complications Meeting. Jackson, Wyoming. 2003 "Endovascular treatment of cerebral aneurysms"; Visiting Professor "Thrombolytic therapy in acute ischemic stroke"; "Recent advances in Interventional MRI/MRA". World Federation of Interventional and Therapeutic Neuroradiology, Scientific Meeting. Recife, Brazil. 2003 "Recent advances in interventional treatment of Visiting Professor aneurysms". Melbourne Medical Society. Melbourne, Australia. 2003 "Advances in Intracranial Stenting: Treatment Strategies". Visiting Professor Korea Interventional Neuroradiology Society. Annual Scientific Session. Seoul, Korea. 2003 "Endovascular approach to difficult cerebral aneurysms". Visiting Professor Perth University Medical Center. Perth, Australia. 2003 "A new coil system for treatment of difficult aneurysms". Visiting Professor North Shore Royal Hospital: Stroke Symposium. Sydney Australia. 2003 "Endovascular approach to acute ischemic stroke". Visiting Professor Global Endovascular Conference. Seoul, Korea. 2003 "Endovascular Therapy for Unruptured Cerebral Visiting Professor Aneurysms"; "Stenting and Coiling for Wide Neck Cerebral Aneurysms". Update of Advances in Endovascular Aneurysm Therapy. Oxford, England. 2003 "Interventional approach to Intracranial Stenting". Visiting Professor

28 of 193 Prepared: October 27, 2015

Cerebrovascular Stroke Conference. Seoul, Korea. 2003 "Endovascular Therapy of Cerebral Aneurysms". Visiting Professor Samsung Medical Center. Seoul, Korea. 2003 "Angioplasty and Stenting For Intracranial Visiting Professor Atherosclerosis". Assan Medical Center, Stroke Conference. Seoul, Korea. 2003 "Advances in the Interventional Treatment of Brain Visiting Professor Aneurysms". Neurosurgery Cerebrovascular Conference. Severance Hospital. Seoul, Korea. 2004 "Interventional Treatment of Intracranial Cerebral Visiting Professor Aneurysms"; "State of the Art Treatment for Intracranial Atherosclerosis". Scientific Advisory Council Meeting on Cerebrovascular Diseases. Bangkok, Thailand. 2004 "State of the Art Treatment for Acute Ischemic Stroke". Visiting Professor Southeast Asia Stroke Meeting. Bangkok, Thailand. 2004 "Recent Trials in Acute Stroke Management"; "Treatment Visiting Professor of Acute Ischemic Stroke: Intra-arterial Thrombolysis Trials"; "Complex Ischemic Stroke Case Series"; "Intracranial Stenting for Acute Ischemic Stroke"; "Treatment of Cervical Atherosclerosis: Carotid Artery Stenting". Stroke Symposium Conference. Buenos Aires, Argentina. 2004 "Carotid Artery Stenting for Atherosclerosis". Annual Visiting Professor Meeting of the Australasian Society of Interventional Neuroradiology. Bangkok, Thailand. 2004 "Interventional Approaches to Acute Ischemic Stroke Visiting Professor Therapy". Annual Scientific Meeting of the European Society of Neurology. Madrid, Spain. 2004 "Interventional Therapies for Acute Ischemic Stroke". 8th International Symposium on Thrombolysis and Acute Stroke Therapy. Whistler British Columbia, Canada. 2004 "Advances in Intracranial Stenting for Cerebral Visiting Professor Atherosclerosis". Tiantan International Stroke Conference, Peoples Republic of China. Beijing, China. 2004 "Recent Advances in the Interventional Therapy for Acute Ischemic Stroke". 5th World Stroke Congress. Annual Scientific Meeting. Vancouver, Canada. 2004 "Intracranial Stenting: Current Research"; "Clinical Visiting Professor Update on Cerebral Aneurysm Therapy". Beijing Neurosurgical Forum. Beijing, China. 2004 "Techniques for Performing Carotid Artery Stenting"; Visiting Professor "UCSF Experience For Treatment of Cerebral Aneurysms". Chongqing 4th Military Hospital. Chongqing, China.

29 of 193 Prepared: October 27, 2015

2004 "Endovascular Approach for Cerebral Aneurysm Therapy". Visiting Professor Tianjin Medical Center. Tianjin, China. 2004 "Advances in the Treatment of Carotid Atherosclerosis"; Visiting Professor "Advances in the Treatment of Cerebral Aneurysms". Xian Medical Center. Xian, China. 2004 "Advances in the Endovascular Treatment of Cerebral Visiting Professor Aneurysms"; "Recent Advances In Acute Stroke Therapy: Diagnosis and Interventions." Annual Meeting of the Korean Stroke Society. Seoul, Korea. 2004 "Use of Coils in Treating Complex Brain Aneurysms". Visiting Professor Inchon Medial Center. Seoul, Korea. 2004 "Interventional Therapy In Cerebrovascular Disease"; Visiting Professor "Imaging In Acute Ischemic Stroke"; "Interventional Management of Acute Ischemic Stroke". Hong Kong Stroke Symposium and Workshop. Hong Kong, China. 2004 "Use of Stents In Cerebrovascular Diseases". Intracranial Visiting Professor Stent Conference. Hong Kong, China. 2004 "Endovascular Treatment of Cerebral Aneurysms"; Visiting Professor "Advances in the Endovascular Treatment of Cerebral Aneurysms". Hong Kong Society of Interventional Neuroradiology. Hong Kong, China. 2004 "Advances In Imaging and Treatment of Cerebral Visiting Professor Aneurysms". Prince of Wales Medical Center, Neuroradiology Symposium. Hong Kong, China. 2005 "Advances in Treatment and Diagnosis of Cerebral Visiting Professor Aneurysms". Summit Neurovascular Conference. Quebec, Canada. 2005 "Diagnostic and Therapeutic Considerations in Treating Visiting Professor Ruptured Cerebral Aneurysms"; "Advances in Acute Ischemic Stroke Therapy"; "Advances in Acute Ischemic Stroke Therapy"; "Recent Advances in the Endovascular Treatment of Cerebral Aneurysms". The 6th International Congress on Minimally Invasive Neurosurgery. Nagoya, Japan. 2005 "Endovascular vs. Surgical Treatment of Cerebral Visiting Professor Aneurysms"; "Intracranial Stenting For Cerebral Atherosclerosis". The Japanese Congress of Neurosurgery. Nagoya, Japan. 2005 "Recent Advances In The Diagnostic and Endovascular Visiting Professor Treatment Of Carotid And Cerebral Atherosclerosis". Live Conference and Case Demonstration: Endovascular Neurosurgery. Nagoya, Japan. 2005 "UCSF Experience is Using the DCS Coil to Treat Visiting Professor Cerebral Aneurysms". Japanese Endovascular Neurosurgery Working Group. Nagoya, Japan.

30 of 193 Prepared: October 27, 2015

2005 "Current State of the Art For Ischemic Stroke". Asia Visiting Professor Pacific Neuro Interventional Radiology Consensus Meeting. Hanoi, Vietnam. 2005 "The UCSF Experience For Treatment of Cerebral Visiting Professor Aneurysms"; "Recent Advances In Carotid Artery & Intracranial Stenting". South American Congress of Neurosurgery. Lima, Peru. 2005 "Intracranial Atherosclerosis: Recent Advances in Visiting Professor Angioplasty, Stenting, and the Use of Anti-Platelet ". The Japanese Annual Congress of Neurosurgery. Tokyo, Japan. 2005 "Use of Anti-Platelet Agents In Acute Ischemic Stroke". Visiting Professor Medical Conference on Stroke. Tokyo Metropolitan Geriatric Hospital. Tokyo, Japan. 2005 "Advances In Intracranial Angioplasty and Stenting". Visiting Professor Japan Endovascular Neurosurgery Symposium. Tokyo, Japan. 2005 "Treatment of Intracranial Atherosclerosis: Recent Visiting Professor Advances In Imaging & Treatment"; "Recent Advances in the Endovascular Treatment of Brain Aneurysms and Ischemic Stroke". Annual Meeting of the Japanese Endovascular Neurosurgery Society. Wakayama, Japan. 2005 "Use of the Enterprise Stent For Treatment of Complex Cerebral Aneurysms". World Federation of Interventional & Therapeutic Neuroradiology. Annual Scientific Meeting. Venice, Italy. 2005 "Endovascular treatment of hemorrhagic brain diseases."; Visiting Professor "Intracranial Revascularization Therapies: Recent Advances". Indo-U.S. Symposium On Cerebrovascular Disorders. The Indo-U.S. Science and Technology Forum. India Habitat Centre, New Delhi, India. 2005 "Advances In The Endovascular Treatment of Cerebral Visiting Professor Aneurysms". China Aneurysm Symposium. Shenyang, China. 2005 "Current State of the Art In Aneurysm Therapy". Visiting Professor Cerebrovascular Symposium. Kunming, China. 2005 "The UCSF Experience For Treatment of Difficult Cerebral Visiting Professor Aneurysms". Stroke Symposium. Shanghai, China. 2006 "Aneurysm Treatment in the United States- Current & Visiting Professor Future Technologies". 7th Annual Kinki Neuro Interventional Radiology Conference. Nara, Japan. 2007 "State of the Art Treatment For Hemorrhagic Stroke and Visiting Professor Cerebral Aneurysms"; "State of the Art: Recent Advances In Imaging of Cerebrovascular Diseases". The Asian- Oceanic International Symposium of Head and Neck

31 of 193 Prepared: October 27, 2015

Radiology. Singapore. 2007 "Intracranial Revascularization Therapies: Recent Visiting Professor Advances In Diagnosis and Treatment". Endovascular Symposium. Singapore. 2007 "Recent Advances In Intracranial Stenting"; "New Coils Visiting Professor and Stents For Intracranial Aneurysms". 13th World Federation of Neurosurgery Meeting. Nagoya, Japan. 2007 "Endovascular Techniques For Intracranial Stenting"; Visiting Professor "Treatment of Complex Cerebral Aneurysms with the Enterprise Stent". Special Symposium on Intracranial Stenting. Singapore. 2007 "Recent Advances In the Treatment of Carotid Visiting Professor Atherosclerosis"; "Carotid Artery Stenting". 12th Asian Association Congress of Neurosurgery. Nagoya, Japan. 2007 "Recent Advances In the Treatment of Acute Ischemic Visiting Professor Stroke". Cerebrovascular Symposium. Nagoya, Japan. 2008 "Skull Base Embolization: Dangers & Pitfalls"; Visiting Professor "Endovascular Approaches to Complex Carotid Lesions"; "New Frontiers in Stroke Salvage: Imaging Therapy". Keynote Lecture. 8th Annual Asia Pacific Congress of Cardiovascular & Interventional Radiology. Kuala Lumpur, Malaysia. 2008 "Stent Assisted Coiling: Use of the Enterprise Stent"; Visiting Professor "Angioplasty &amp; Stenting of Intracranial Atherosclerosis". Endovascular & Stroke Symposium. Kuala Lumpur, Malaysia. 2008 "Interventional MRI In Cerebrovascular Diseases"; Visiting Professor "Intracranial Stenting: Use of the Wingspan Stent". Symposium on Imaging and Therapeutics. Kuala Lumpur, Malaysia. 2008 "Stenting & Angioplasty For Acute Interventions In Visiting Professor Ischemic Stroke". 6th World Stroke Congress. Vienna, Austria. 2008 "Interventions For Cerebral Ischemia". Cerebrovascular Visiting Professor Stroke Symposium. Vienna, Austria. 2009 "Intracranial Stenting: State of the Art"; "Use of and Visiting Professor Detachable Coil Systems". Australian and New Zealand Society of Neuroradiology, Annual Scientific Conference. Quay West Bunker Bay, Western Australia. 2009 "Evaluation and treatment of Acute Ischemic Stroke". Visiting Professor Makati Medical Center Stroke Symposium. Manila, Philippines. 2009 "Carotid Artery Stenting: Current Status, Trials, and Visiting Professor Techniques". Interventional Neuroradiology Conference. Australia.

32 of 193 Prepared: October 27, 2015

2009 "Newer Imaging Technologies of the Brain". New Frontiers Visiting Professor in Stroke Conference. Manila, Philippines. 2009 "Evaluation and Treatment of Hemorrhagic Stroke". Hong Visiting Professor Kong Sanatorium Hospital. Stroke Symposium. Hong Kong. 2009 "Newer Imaging Technologies of the Brain". Asian Visiting Professor Hospital Medical Center Stroke Symposium. Manila, Philippines. 2010 "Balloon Angioplasty & Stenting For Intracranial Visiting Professor Atherosclerosis"; "Recent Advances in the Diagnosis and Treatment of Acute Ischemic Stroke". 7th China Forum on Cerebrovascular Diseases. Beijing, China. 2010 "Newer Imaging Technologies of the Brain". National Visiting Professor Taiwan University Hospital. Taiwan, China. 2010 "Evaluation and Treatment of Acute Ischemic Stroke". Visiting Professor Army Military Hospital in Jakarta. Grand Rounds Medical Forum. Jakarta, Indonesia. 2010 "Advances in the Interventional Treatment of Acute Visiting Professor Ischemic Stroke"; "Interventional Treatment of Intracranial Atherosclerosis". Third International Neurology Symposium. Santiago, Chile. 2010 "Current Trials in Carotid Artery Stenting". Neurosurgery Visiting Professor & Endovascular Symposium. Beijing, China. 2010 "Evaluation and Treatment of Acute Hemorrhagic Stroke". Visiting Professor Neurosurgical Symposium on Cerebrovascular Diseases. Jakarta, Indonesia. 2010 "Carotid Artery Atherosclerosis: Stenting vs. Surgery"; Visiting Professor Cerebrovascular and Stroke Conference. Santiago, Chile. 2011 "Treatment of Acute Ischemic Stroke"; "Comparative Visiting Professor Results of Carotid Artery Stenting vs. Carotid Endarterectomy". The Asian Oceanian Conference on Cerebrovascular Disease. Shanghai, China. 2011 "Interventional Neuroradiology: Recent Advances in Visiting Professor Imaging and Treatment of Acute Ischemic Stroke"; "Endovascular Approach and Techniques For Carotid and Intracranial Revascularization". The XXth World Congress of Neurology. Marrakesh, Morocco. 2011 "Endovascular Treament of Carotid and Intracranial Visiting Professor Atherosclerosis". Endovascular Neurosurgery Forum. Shanghai, China. 2012 " Treated By Endovascular Visiting Professor Stenting"; "The Imaging Evaluation of Acute Stroke". The 10th International Conference on Cerebrovascular Surgery. Beijing, China.

33 of 193 Prepared: October 27, 2015

2012 "Treatment of Carotid Artery Disease: Stent Strategies"; Visiting Professor "Stroke Treatment: Mechanical Reperfusion Strategies". 8th World Stroke Congress, Brasilia, Brazil. 2014 "Current State of the Art Treatments in Intra-Arterial Visiting Professor Stroke Therapies"; "Endovascular Treatments of Cerebral Artery Aneurysms"; "Intra-Arterial Thrombolytic Therapy". International Neurological Symposium; Santiago, Chile.

NATIONAL 1986 "Real time digital subtraction angiography", Radiological Society of North America, 71st Scientific Session, Chicago, Illinois. 1987 "Interventional neuroradiology: Technological advancements and clinical applications in an emerging field". New Frontiers in Diagnostic Imaging Conference, Chicago, Illinois. 1988 "Current status of interventional neuroradiology", Visiting Professor Neurosurgical and Neurological Society of New Mexico, Santa Fe, New Mexico. 1988 "Complications of intravascular aneurysm therapy", Working group in Interventional Neuroradiology, Keystone, Colorado. 1988 "Techniques of embolization of brain AVMs with solid Visiting Professor particles"; "Treatment of intradural aneurysms of the internal carotid and vertebro-basilar "; "Transluminal angioplasty of intracranial arterial vasospasm"; "Treatment of dural types of carotid cavernous fistulas through the venous route", Second National Course in Interventional Neuroradiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 1989 "Treatment of intracranial aneurysms and vasospasm", American Society of Neuroradiology. Categorical Course on Cerebrovascular Disease. Orlando, Florida. 1989 "Neuroembolic procedures of the Central Nervous System", Current Advances in Diagnostic Imaging and Percutaneous Surgery Conference. San Antonio, Texas. 1990 "Current advances in the field of Interventional Neuroradiology". Clinical Radiology Update Symposium. Western Anaheim Medical Center. Anaheim, California. 1990 "Angioplasty and fibrinolysis."; "Treatment of non Visiting Professor surgical intracranial aneurysms." ; "Embolization of brain arteriovenous malformations with particulate emboli."; "Current concepts on carotid cavernous fistulae and dural vascular malformations."; "Endovenous treatment of dural arteriovenous malformations."; "Endovascular treatment of CCF of dural AV type." ; "Emergencies.

34 of 193 Prepared: October 27, 2015

Traumatic vascular lesions and epistaxis." Interventional Neuroradiology Symposium: Current practices and technique. Johns Hopkins University Medical Center. 1990 "The impact of neuroradiology in the diagnosis and treatment of Cerebrovascular Disease"; "Interventional neuroradiology of lesions involving the cavernous internal carotid artery". Annual Meeting of the American College of Surgery. Neurosurgery Section. San Francisco, California. 1990 "Interventional neurovascular techniques for treatment of complex intracerebral lesions". Annual Meeting of the American Association of Neurological Surgeons. Los Angeles, California. 1991 "Vascular treatment of cerebral aneurysms: Techniques, Results, and Complications."; "Thrombolysis and re- canalization of the cerebral vasculature"; "Transluminal angioplasty of brachiocephalic vessels." Annual Meeting of the American Society of Neuroradiology. Interventional Neuroradiology Course. Washington, D. C. 1991 "Recent Advances in Interventional Neuroradiology" Sixteenth Annual Meeting of the Society of Cardiovascular and Interventional Radiology. San Francisco, California. 1991 "Fibrinolysis and anticoagulation during neurointerventional procedures". Fourth Annual Meeting on Complications in NeuroInterventional Radiological Procedures. Jackson, Wyoming. 1992 "NeuroInterventional Radiology." Radiological Society of North America. National and Scientific Session. Chicago, Illinois. 1992 "Interventional Neuroradiology: Treatment of Intracranial Aneurysms." ; "Interventional Neuroradiology: Treatment of Intracranial arterial vasospasm." American Heart Association. Advances in Cerebrovascular Disease and Stroke. Honolulu, Hawaii. 1992 "Recent advances in the field of Interventional Visiting Professor Neuroradiology." Stroke Scientific Symposium. Boston, Massachusetts. 1992 "Advances in the field of Interventional Neurovascular Visiting Professor Radiology." Stroke Symposium. Minneapolis, Minnesota. 1992 "Deep arteriovenous malformations. Endovascular therapy."; "Lesions of the Cavernous Sinus: Interventional Approach." American Association of Neurological Surgeons. Sixtieth Annual National Scientific Program. San Francisco, California.

35 of 193 Prepared: October 27, 2015

1992 "Advances in the field of Interventional Neuroradiology." Advances in Neuroradiology, Neurosurgery, and Neuroscience Technology. San Diego, California. 1992 "Recent advances in Interventional Neurovascular Visiting Professor Radiology." Endovascular Symposium, Miami, Florida. 1992 "NeuroInterventional Radiology." Radiological Society of North America. National and Scientific Session. Chicago, Illinois. 1992 "Endovascular treatment of cerebral arteriovenous malformations." Western Neurosurgical Society. Thirty Sixth Annual Meeting. Vancouver, British Columbia. 1992 "Techniques used in Endovascular Neurosurgery: Treatment of Cerebral Arterial Venous Fistulas."; "Percutaneous Transluminal Cerebral Angioplasty." Congress of Neurological Surgeons. Practical Course for Neurosurgery. Washington, D.C. 1992 "Advances in Treatment in Interventional Neuroradiology." American Radiological Nurses Association National Meeting. Chicago, Illinois. 1993 "Recent Advances in Interventional Neuroradiology." American Roentgen Ray Society. 93rd Annual Meeting. San Francisco, California. 1993 "Treatment of Stroke by Revascularization Techniques." Visiting Professor Vascular Medicine in the 90's: Recent Advances in the Management of Peripheral Vascular Disease. Creighton Vascular Center. Omaha, Nebraska. 1993 "Outcomes of Thrombolysis in Stroke: Intra-arterial Thrombolysis."; "Interventional Techniques in Thrombolysis." Symposium on Thrombolytics in Stroke. Biologics Division of the Federal Food and Drug Administration. Washington, D.C. 1993 "Interventional Techniques for Thrombolysis." American Society of Neuroradiology. Annual Scientific Meeting. Symposium on Acute Stroke. Vancouver, Canada. 1993 "Intra-arterial digital subtraction angiography". International Symposium on Contrast Agents for Vascular Diagnosis. Aventura, Florida. 1993 "Detachable Silicone Balloon use in Interventional Neurovascular Radiology." Federal Food and Drug Administration Panel Meeting. Washington, D.C. 1993 "Interventional techniques in thrombolysis." Stroke Advisory Committee Meeting. Chicago, Illinois. 1993 "Emergency Interventional Neuroradiological Procedures: Visiting Professor Trauma, Stroke, Hemorrhage." Emergency Assessment of Rural Trauma Meeting. Glasgow, Montana.

36 of 193 Prepared: October 27, 2015

1993 "Thrombolysis in Stroke Therapy". FDA Panel Meeting, Biologics Division. Bethesda, Maryland. 1993 "Interventional Techniques in Neuroradiology". Radiological Society of North America. Scientific Sessions. 79th Annual Assembly. Chicago, Illinois. 1993 "The role of thrombolytic and anti-vasospastic agents in the treatment of stroke". 25th Annual Meeting of the Western Neuroradiological Society. Pasadena, California. 1993 "Interventional techniques for cerebral angioplasty and Visiting Professor thrombolysis". Acute Stroke Therapy Symposium. Nashville, Tennessee. 1993 "Radiological techniques in thrombolysis". Investigators Meeting for Acute Stroke with Intra Arterial Thrombolysis. Chicago, Illinois. 1994 "Interventional Neuroradiology". Endovascular Stroke Visiting Professor Symposium. Miami, Florida. 1994 "Interventional treatment of giant intracranial aneurysms."; "Endovascular Management of Complex Cerebrovascular Disorders." American Association of Neurological Surgeons. Annual Scientific Meeting. San Diego, California. 1994 "Treatment of Stroke by Revascularization Techniques." Visiting Professor Changing Perspectives in the Management of Stroke Symposium. Colorado Radiological Association. Brown Palace Hotel, Denver, Colorado. 1994 "Advances in Endovascular Neurosurgical Therapy." Visiting Professor Neuro Interventional and Neurosurgical Symposium. Miami Lakes, Florida. 1995 "Cerebrovascular Interventions: Brave New World." Cardiology 1995: Concepts and Controversies. Sacramento, California. 1995 "Overview of Stroke and Cerebrovascular Disorders." Workshop on New Technology for the Treatment of Stroke. Department of Energy, Office of Health and Environmental Research. Lawrence Livermore National Laboratory. Livermore, California. 1995 "Acute thrombolysis for arterial and venous ." American Society of Interventional and Therapeutic Neuroradiology and the American Society of Neuroradiology. Annual Scientific Meeting. Chicago, Illinois. 1995 "Carotid artery intervention: Time for Scientific Visiting Professor Investigation and Validation." Panel Discussion. 6th Annual Percutaneous Transluminal Cerebral Angioplasty Meeting. Birmingham, Alabama.

37 of 193 Prepared: October 27, 2015

1995 "Endovascular approach to cerebral arteriovenous malformations." The 45th Annual Scientific Meeting of the Congress of Neurological Surgeons. San Francisco, California. 1996 "Cerebral angioplasty and stenting from a NeuroInterventional perspective." North American Neuro Interventional Symposium. Miami, Florida. 1996 "Interventional neurovascular treatment of acute stroke". Society of Cardiovascular and Vascular Interventional Radiology. Annual Scientific Meeting. Plenary Session. Seattle, Washington. 1996 "Cerebral transluminal angioplasty: Current Status". U.S. FDA Neurological Devices Panel Meeting. Bethesda, Maryland. 1996 "Current Status of Cerebral Angioplasty and Stenting." The Carotid Artery Stenting and Endarterectomy Trial Working Group. Chicago, Illinois. 1996 "Current status of Carotid Artery Stenting and Angioplasty". Health Industry Manufacturer's Association: Interventional Cardiology Task Force. Washington, D.C. 1996 "Carotid Angioplasty and Stenting"; "Intra-arterial Visiting Professor thrombolytic therapy for acute stroke intervention." Advanced Cardiovascular Guidance: Utilizing New Technologies for Treatment of Vascular Disease. Atlanta, Georgia. 1996 "Thrombolytic Therapy in Acute Stroke Therapy." The PROACT Working Group. Chicago, Illinois. 1996 "Complications associated with neurointerventional Visiting Professor procedures." Global Revascularization: Complication Avoidance and Management. New York, New York. State University of New York. 1996 "Endovascular extracerebral and intracerebral interventions." American Heart Association. 69th Scientific Sessions, Plenary Meeting. New Orleans, Louisiana. 1997 "Interventional management of the acute stroke patient." Visiting Professor Management of Venous Disease and Stroke Symposium. Phoenix, Arizona. 1997 "Cerebral Percutaneous Transluminal Angioplasty and Stenting."; "Management of Acute Subarachnoid Hemorrhage." Annual Meeting of the Joint Section on Cerebrovascular Surgery. American Heart Association. Anaheim, California. 1997 "Recent advances in Acute Stroke Therapy Intervention: Cerebral thrombolysis, Carotid artery stenting,

38 of 193 Prepared: October 27, 2015

Intracranial aneurysm management." American Society of Neuroradiology. 35th Annual Scientific Meeting. Toronto, Canada. 1997 "Interventional techniques for extracerebral lesions in acute stroke". Annual Meeting of the Western Angiography Society. San Francisco, California. 1997 "Cerebral thrombolysis in acute stroke therapy management." The IX Annual Scientific Meeting for Transcatheter Cardiovascular Therapeutics. Washington, DC. 1997 "Angiographic techniques in acute stroke". Investigators Meeting of the PROACT National Phase III study. Chicago, Illinois. 1998 "Risk analysis of atherosclerotic disease." The Annual Meeting of the Joint Section on Cerebrovascular Surgery. Orlando, Florida. 1998 "Technical considerations in Intra-arterial thrombolysis". Acute Cerebral Stroke Symposium. San Diego, California. 1998 "Complex cerebral ischemia management cases" ; "Management of deep cerebral AVM's." American Society of Interventional and Therapeutic Neuroradiology. Orlando, Florida. 1998 "Carotid artery angioplasty and stenting."; "Interventional treatment for carotid atherosclerosis." Annual Scientific Meeting of the Society of Cardiovascular and Interventional Radiology. San Francisco, California. 1998 "Intra-arterial thrombolysis in acute ischemic stroke". Advanced Cardiovascular Guidance II. Atlanta, Georgia. 1998 "Interventional Treatment of Intracranial Aneurysms." Western Neuroradiological Society 30th Annual Meeting. Santa Fe, New Mexico. 1998 "Intracranial Angioplasty."; "Neurovascular rescue and thrombolysis". Advanced Endovascular Demonstrations: Crossroads in Carotid Disease. Newport Beach, California. 1998 "Carotid Artery Angioplasty and Stenting: Controversies Visiting Professor in acute stroke therapy management". Cerebrovascular Symposium. Indianapolis, Indiana. 1999 "Expert Panel Discussion: Carotid Artery Disease"; "Intra-arterial thrombolysis for acute stroke". Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. Nashville, Tennessee.

39 of 193 Prepared: October 27, 2015

1999 "Acute stroke therapy interventions." Medical Visiting Professor Center Conference. Portland, Oregon. 1999 "Endovascular treatment of acute stroke." Annual Scientific Meeting of the Society of Cardiovascular and Interventional Radiology. Orlando, Florida. 1999 "Interventional techniques in acute stroke therapy intervention." Annual Scientific Meeting of the American Academy of Neurology. Toronto, Canada. 1999 "Intra-arterial thrombolysis in acute stroke interventions". Neuro Therapeutics Investigators Meeting. Chicago, Illinois. 1999 "Intra-arterial thrombolytic therapy in acute stroke: Proact II results." Annual Scientific Meeting of the American Society of Neuroradiology. San Diego, California. 1999 "Carotid artery stenting and thrombolysis."; "Endovascular stenting of the carotid artery"; "Cerebral fibrinolysis."; Eighth Annual Interventional Radiology and Endovascular Therapy Seminar. Chicago, Illinois. 1999 "Establishing an acute stroke program: Logistics, Personnel, Case Selection, and Regulatory Issues"; "Management of acute stroke with fibrinolytic therapy and percutaneous techniques." Transcatheter Cardiovascular Therapeutics. 11th Annual Symposium. Washington, DC. 1999 "Recent advances in acute stroke therapy". National Visiting Professor Stroke Summit Meeting. Brunswick, New Jersey. 1999 "Interventional approach to acute stroke management". American Heart Association, Scientific Conference. San Francisco, California. 1999 "Transcatheter techniques for acute stroke therapy." 72nd Annual Scientific Meeting of the American Heart Association. Scientific Session. Atlanta, Georgia. 1999 "Intracranial Stenting: Techniques, Applications, Outcomes."; "Carotid Artery Stenting: Techniques, Applications, Outcomes." Annual Scientific Meeting of the Radiological Association of North America. Chicago, Illinois. 2000 "Expert Debate: Carotid Stenting for Moderate Symptomatic Stenosis"; "Carotid artery stenting techniques". Third Annual Scientific Session of the American Society of Interventional and Therapeutic Neuroradiology and Joint Section of Cerebrovascular Neurosurgery. New Orleans, Louisiana. 2000 "Neurovascular Rescue: Thrombolysis vs. PTA". Advanced Endovascular Live Demonstrations 2000. Anaheim, California.

40 of 193 Prepared: October 27, 2015

2000 "Neurovascular Interventional Procedure Workshop". Annual Meeting of the Society of Cardiovascular and Interventional Radiology Scientific Meeting. San Diego, California. 2000 "Carotid Artery Angioplasty and Stenting". Annual Meeting of the American Society of Neuroradiology. General Scientific Session. Atlanta, Georgia. 2000 "Carotid Artery Stenting"; "Newer techniques in Acute Stroke Therapy". Annual Meeting of the California Radiological Society. Monterey, California. 2000 "Complications of Basilar Artery Aneurysm Therapy". Neuro Interventional Complications Meeting, Jackson, Wyoming. 2000 "Techniques for carotid angioplasty and stenting"; "Clinical experience with carotid angioplasty and stenting."; "Carotid Stenting: Who, when, and if?" ; "Thrombolytic therapy in acute ischemic stroke"; "Intra-procedural stenting techniques" Symposium on Vascular Interventions. Las Vegas, Nevada. 2000 "Endovascular Treatment of Carotid Atherosclerosis". Visiting Professor Endovascular Symposium. Houston, Texas. 2000 "Acute Brain Reperfusion: Thrombolytics, Stenting, and Beyond"; "How to Stent the Carotid Artery". Annual Scientific Meeting of the American Heart Association. 73rd Scientific Session. New Orleans, Louisiana. 2001 "Carotid Artery Stenting: Endovascular Techniques". Annual Meeting of the Joint Section of Cerebrovascular Neurosurgery and American Society of Interventional and Therapeutic Neuroradiology". Waikoloa, Hawaii. 2001 "Recent Clinical Trials in Carotid Artery Stenting: An Update"; "Carotid Artery Stenting: Indications and Techniques". Annual Meeting of the Society of Cardiovascular and Interventional Radiology. San Antonio, Texas. 2001 "Medical Management Pre-, During, and Post Stenting"; "Politics of Carotid Artery Stenting"; "Carotid Stenting- Complex Lesions". Cerebral Revascularization Workshop. Tampa, Florida. 2001 "Cerebral Thrombolysis Trials in Acute Ischemic Stroke". FDA Advisory Panel Meeting. Bethesda, Maryland. 2001 "Extracranial Angioplasty and Stenting: Techniques and Results". Association of Vascular and Interventional Radiology Technologists. San Antonio, Texas. 2001 "The Maveric Carotid Artery Stent Trial". Principal Investigators Meeting for the AVE Carotid Artery Stent Trial Collaborators". Orlando, Florida.

41 of 193 Prepared: October 27, 2015

2001 "Coiling of Intracranial Aneurysms". U.S Congressional Subcommittee Meeting. Palm Springs, California. 2001 "How to handle common coding problems in Neuroradiology"; "A peek into the crystal ball: Technology, Billing-Coding, Credentialing, Turf Issues"; American Society of Neuroradiology Annual Scientific Meeting. Boston, Massachusetts. 2001 "Bloodless Surgery: Carotid Surgery by Endovascular Stenting". Annual Meeting of the Society of Cardiovascular Anesthesiology. Vancouver, British Columbia. 2001 "Asymptomatic Carotid Diseases: Carotid Artery Stenting". 70th Annual John J. Sampson American Heart Association Symposium on Cardiovascular Diseases. San Francisco. California. 2001 "Advances in Acute Ischemic Stroke"; "Clinical perspectives of Interventional MRI/MRA in Acute Stroke Therapy"; Interventional Scientific Symposium, Miami, Florida. 2002 "Technical Aspects of Extracranial and Intracranial Revascularization". "Endovascular Therapy for Cerebral Revascularization". 5th Annual Scientific Meeting of the ASITN and Joint Section of Cerebrovascular Neurosurgery. Dallas, Texas. 2002 "Endovascular Neurosurgery". Annual Meeting of the American Academy of Neurology: Stroke Symposium. Denver, Colorado. 2002 "Carotid Artery Stenting: Current Results and Clinical Trials: Are We As Good As Surgery". 40th Annual Scientific Meeting of the American Society of Neuroradiology. Vancouver, British Columbia. Canada. 2002 "Interventional Treatment of Cerebral Rescue and Revascularization". Interventional Cardiac and Vascular Therapies. Seattle, Washington. 2002 "Carotid artery stenting: Current Trials, Results, Politics"; "Recent Advances in Acute Ischemic Stroke Therapy"; Annual Scientific Meeting of the Western Interventional Angiography Society. Maui, Hawaii. 2002 "Carotid Artery Stenting: Current Clinical Trials and Techniques". American Heart Association, Annual Scientific Meeting. Chicago, Illinois. 2002 "A Practical Approach to Carotid Artery Stenting". American Society of Interventional and Therapeutic Neuroradiology and Society of Interventional Radiology, Practical Course on Carotid Artery Stenting. Portland, Oregon.

42 of 193 Prepared: October 27, 2015

2002 "Advances in the Interventional Treatment of Acute Ischemic and Hemorrhagic Stroke". Symposium on Acute Ischemic Stroke. Spokane, Washington. 2002 "Techniques for Angioplasty and Stenting: A Practical Approach"; "Carotid Artery Angioplasty vs. Surgery"; Radiological Society of North America. Annual Scientific Meeting. Chicago, Illinois. 2003 "Intra-Arterial Thrombolytic Therapy in Acute Stroke". Symposium on Acute Stroke Interventions. Miami, Florida. 2003 "Mechanical Devices for Acute Ischemic Stroke". Stroke Symposium Forum. Phoenix, Arizona. 2003 "Endovascular Treatment vs. Surgery For Cerebral Aneurysm Therapy". International Symposium on Endovascular Therapy. Miami, Florida. 2003 "Expert Approaches to Complex Aneurysm Treatment". Visiting Professor Aneurysm Symposium. Phoenix, Arizona. 2003 "Use of Snare Devices for Acute Ischemic Stroke". Acute Ischemic Stroke Conference. Ft. Lauderdale, Miami. 2003 "Advances in the Endovascular Treatment of Acute Visiting Professor Ischemic Stroke". Queens Medical Center, Acute Stroke Symposium Forum. Grand Rounds. Honolulu, Hawaii. 2003 "Presidential Address: The Future of Interventional Neuroradiology in the Next Decade"; "Current Clinical Trials in Carotid Artery Stenting"; "Endovascular Approaches to Cervical Atherosclerosis"; Annual Meeting of the Joint Section of Cerebrovascular Neurosurgery and the American Society of Interventional and Therapeutic Neuroradiology. Phoenix, Arizona. 2003 "A Practical Approach to Carotid Artery Stenting". Annual Scientific Meeting of the American Society of Neuroradiology. Washington, DC. 2003 "Endovascular Coil Embolization of Intracranial Cerebral Aneurysms". Cerebral Aneurysm Symposium. Miami, Florida. 2003 "Intracranial atherosclerosis as an Unrecognized Cause Visiting Professor of Ischemic Stroke". Society of Vascular Medicine. Annual Scientific Meeting. Chicago, Illinois. 2003 "Interventional Neuroradiology in the Management of Acute Stroke". U.S. Congressional Forum Session of the American Society of Neuroradiology. Washington, DC. 2003 "Advances in the Field of Acute Ischemic Stroke". Interventional Stroke Symposium. Miami, Florida.

43 of 193 Prepared: October 27, 2015

2003 "Recent Advances in the Endovascular Treatment of Ischemic Stroke". The American Society of Interventional and Therapeutic Neuroradiology First Annual Practicum. Washington, DC. 2003 "Stroke Diagnosis and Treatment". Summer In Seattle Endovascular Therapy Symposium. Seattle, Washington. 2003 "Intracranial Stenting: Which Patients and When". Visiting Professor Neurocritical Care 2003: Here Comes the Sun. Cleveland Clinic Medical Center. 2003 "Current Clinical Trials and Results of Carotid Artery Stenting". Society of Interventional Radiology and American Society of Interventional and Therapeutic Neuroradiology Research Conference: Stroke Interventions. Bethesda, Maryland. 2003 "Acute Interventions in Stroke Therapy". American Heart Association, San Antonio Division. San Antonio, Texas. 2003 "Carotid Artery Stenting: Will It Replace Surgical Endarterectomy". Annual Meeting of the Society of Neurosurgical Anesthesia and Critical Care. San Francisco, California. 2003 "A new filter device to prevent acute thrombo-embolic stroke". U.S. FDA Medical Devices Meeting. Bethesda, Maryland. 2003 "Complications associated with intracranial stenting of wide necked cerebral aneurysms". Cerebral Aneurysm Symposium. Miami, Florida. 2004 "Endovascular Approach to Complex Poor Grade Cerebral Aneurysm Patients". Annual Meeting of the Joint Section of Cerebrovascular Neurosurgery and American Society of Interventional and Therapeutic Neuroradiology. San Diego, California. 2004 "Recent Trials in Carotid Artery Stenting". Interventional Visiting Professor Radiology Research Conference. Bethesda, Maryland. 2004 "Intracranial Stenting for Cerebral Atherosclerosis". New Developments and Controversies in Cerebrovascular Intervention. San Diego, California. 2004 "Recent Advances in Acute Ischemic Stroke". Atlanta Visiting Professor Stroke Society Meeting. Atlanta, Georgia. 2004 "Recent Advances in Acute Ischemic Stroke Therapy". Visiting Professor Annual Scientific Meeting of the North Carolina Association of Pharmacists Acute Care Practice Forum Meeting. Greensboro, North Carolina. 2004 "Advances in the Interventional Treatment of Acute Visiting Professor Ischemic Stroke". Stroke Symposium. Knoxville,

44 of 193 Prepared: October 27, 2015

Tennessee. 2004 "Recent Advances in the Treatment of Acute Ischemic Visiting Professor Stroke: Thrombolytic Therapy". Cerebrovascular Disease Conference. Chattanooga, Tennessee. 2004 "Endovascular Treatment of Cerebral Aneurysms". Cerebral Aneurysm and Stroke Conference. Miami, Florida. 2004 "Results of the Maveric I/II Clinical Trials in Carotid Artery Stenting." The MAVERIC Trialists Investigators Meeting. Chicago, Illinois. 2004 "The Use of Drug Eluting Stents For Intracranial Disease". U.S. Food and Drug Administration Symposium. Bethesda, Maryland. 2005 "Intracranial Stenting In Acute Ischemic Stroke"; "Management of Poor Grade Cerebral Aneurysm Patients". Annual Meeting of the American Society of Interventional and Therapeutic Neuroradiology and the Joint Council of Cerebrovascular Neurosurgery. New Orleans, Louisiana. 2005 "Current Use of Anti-Platelet Therapy in Stroke Patients". Expert Scientific Advisory Committee Meeting. Phoenix, Arizona. 2005 "Treatment Strategies For Acute Ischemic Stroke". Cerebrovascular Symposium. Ft. Lauderdale, Florida. 2005 "Non-Pharmacologic Therapy For Acute Ischemic Stroke"; "The Approval Process of the MERCI Concentric Device: Panel Discussion"; "The Enterprise Stent For Treatment of Wide-Neck Aneurysms". Annual Scientific Meeting of the American Stroke Association. New Orleans. Louisiana. 2005 "Current Diagnosis and Treatment of Acute Ischemic Stroke". Stroke Symposium Presentation. San Jose, California. 2005 "Recent Advances In Acute Ischemic Stroke Therapy". Visiting Professor Summer in Seattle. 5th Annual Meeting. Seattle. Washington. 2005 "Complications of Interventional Neuroradiology Procedures: Intracranial Stenting". Annual Morbidity/Mortality Conference. Jackson, Wyoming. 2005 "Recent Advances In Interventional Neuroradiology". Visiting Professor The Charles T. Dotter Memorial Lecture. AHA Cardiovascular Council Award. AHA Scientific Sessions. San Antonio, Texas. 2005 "Use of Bare Metal Platinum Coils for Treatment of Cerebral Aneurysms"; "How To Manage &amp;

45 of 193 Prepared: October 27, 2015

Avoid Complications During Carotid Artery Stenting"; "Use of Microcatheters & Guidewires During Neurointerventional Procedures". The Second Annual Meeting of the American Society of Interventional and Therapeutic Neuroradiology. Oahu, Hawaii. 2005 "Use of Self Expanding Stents To Treat Intracranial Cerebral Atherosclerosis". Cerebrovascular Stent Symposium. Ft. Lauderdale, Florida. 2006 "Recent Advances In Carotid Artery Stenting and Acute Visiting Professor Ischemic Stroke". The American Heart Association Annual Meeting. Memorial Awards Lecture. Dallas, Texas. 2006 "Advances In The Endovascular Treatment Of Visiting Professor Hemorrhagic Stroke". Hawaii Neurosurgical Society. Honolulu, Hawaii. 2006 "Advances in Imaging In Acute Ischemic Stroke". Stroke Symposium. Miami, Florida. 2006 "Recent advances in the treatment of acute ischemic Visiting Professor stroke". Cerebrovascular and Stroke Symposium. New York, New York. 2006 "Advances In Stroke Therapy". Honolulu Medical Visiting Professor Society. Honolulu, Hawaii. 2006 "Use of the Merci Retrieval for acute ischemic stroke". National Stroke Symposium. Las Vegas, Nevada. 2007 "Use of the Enterprise Stent to Treat Complex Visiting Professor Aneurysms". Symposium on Intracranial Stenting. Houston, Texas. 2007 "The Concentric Merci Retriever for Stroke". Acute Ischemic Stroke Symposium Meeting. Las Vegas, Nevada. 2007 "Experience With the Enterprise Stent to Treat Difficult Visiting Professor Cerebral Aneurysms". Symposium on Cerebral Aneurysms. Boston, Massachusetts. 2008 "Results and Complications of Intracranial Stenting with Visiting Professor the Enterprise Stent System". Interventional Neuroradiology Symposium. Troy, Michigan. 2008 "Use of the Enterprise Stent for Treatment of Cerebral Visiting Professor Aneurysms". Endovascular Surgical Symposium. Boise, Idaho. 2008 "Endovascular Surgical Approach for Treatment of Cerebral Aneurysms". Endovascular Neurosurgery Symposium. Miami, Florida. 2008 "Experience of intracranial stents for treatment of Brain Visiting Professor Aneurysms". Interventional Neuroradiology Symposium.

46 of 193 Prepared: October 27, 2015

Salt Lake City, Utah. 2008 "Endovascular Management Of Subarachnoid Invited Speaker Hemorrhage". Neurocritical Care 2008. 6th Annual Neurocritical Care and Stroke Conference. Cleveland, Ohio. 2008 "Clinical Experience with the Enterprise Stent for Visiting Professor Treatment of Complex Cerebral Aneurysms". Southern California Stroke Symposium. Newport Beach, California. 2008 "Experience with the Enterprise Stent for Treatment of Visiting Professor Cerebral Aneurysms". San Diego Stroke Symposium. San Diego, California. 2009 "Treatment of Complex Intracranial Cerebral Aneurysms". Visiting Professor Stroke Symposium. Washington, DC. 2009 "Advances in Acute Ischemic Stroke Therapy". Visiting Professor Endovascular Symposium. Miami, Florida. 2010 "Imaging Techniques In Endovascular Neurosurgery". Visiting Professor Symposium of Cerebrovascular Neurosurgery. Boston, Massachusetts. 2010 "Neuroprotective Agents in Acute Cerebrovascular Diseases". New Drugs and Devices Symposium. Atlanta, Georgia. 2010 "Advances In Endovascular Neurosurgery". Endovascular Neurosurgery Conference. Boston, Massachusetts. 2010 "Intracranial Atherosclerotic Disease: Management and Visiting Professor Therapy". Stroke Symposium. Boston, Massachusetts. 2010 "The Role of Vascular Reconstruction Devices & Coils". Symposium of Complex Cerebral Aneurysm Therapy. San Francisco, CA. 2011 "Endovascular Neurosurgery/Interventional Visiting Professor Neuroradiology". Neuroendovascular Summit Conference. Boston, Massachusetts. 2011 "Advances in Imaging and Therapy for Acute Ischemic Stroke"; "Endovascular Neurosurgery: Complications Avoidance and Management". Cerebrovascular Symposium. Boston, Massachusetts. 2014 "Predicting Aneurysm Growth With Computational Fluid Invited Lectureship Dynamics & Advances In Interventional MRI". Annual Meeting of the Society of Neuro Interventional Surgery. Colorado Springs, Colorado

REGIONAL AND OTHER INVITED PRESENTATIONS 1985 "Intravascular embolization of neurovascular lesions".

47 of 193 Prepared: October 27, 2015

Endovascular Symposium, Palo Alto, California. 1986 "Interventional treatment of neurovascular lesions". Visiting Professor Tulane University School of Medicine. Grand Rounds. New Orleans, Louisiana. 1987 "Advanced techniques in interventional neurovascular Visiting Professor disorders", Santa Rosa Radiological Society, Santa Rosa, California. 1988 "Treatment of Neurovascular Disorders by Interventional Visiting Professor Neuroradiological Techniques". Radiology and Neurosurgery Grand Rounds. University of New Mexico. New Mexico 1988 "Interventional Neurovascular Radiology: Current clinical Visiting Professor applications and techniques", San Jose Radiological Society, San Jose, California. 1988 "Therapeutic advancements in interventional Visiting Professor neuroradiology". Neuroradiology, Neurosurgery, Neurology Grand Rounds. University of Pennsylvania. Medical Center Philadelphia, Pennsylvania. 1988 "Interventional neurovascular radiology". Hoag Memorial Visiting Professor Hospital. Grand Rounds. Newport Beach, California 1989 "Interventional Neuroradiology: Technical advancements Visiting Professor and clinical applications in an emerging field". University of Minnesota Medical Center, Grand Rounds. Minneapolis, Minnesota. 1989 "Interventional management of cerebral aneurysms". Visiting Professor Neurosurgery Conference. Minneapolis, Minnesota. 1989 "Newer therapies in endovascular neurosurgery". VA Visiting Professor Medical Center Grand Rounds. Minneapolis, Minnesota. 1990 "Endovascular therapy for treatment of Intracranial Aneurysms". Southern California Neurosurgical Society Annual Meeting. Santa Barbara, California. 1990 "Recent therapeutic advancements in the field of Visiting Professor interventional neuroradiology". University of Missouri School of Medicine. Grand Rounds. Kansas City, Missouri. 1990 Techniques in the practice of Interventional Neurovascular Therapeutic Radiology." Interventional Therapeutics Symposium. San Francisco, California. 1990 "Advances in the field of interventional neuroradiology". Visiting Professor University of Maryland School of Medicine. Baltimore, Maryland. 1990 "Technical aspects of endovascular surgery for treatment of complex cerebrovascular disorders." Interventional Neuroradiology Symposium, San Jose, California.

48 of 193 Prepared: October 27, 2015

1992 "Thrombolysis and angioplasty of intracranial and Visiting Professor extracranial vascular disease." Orange County Neuroradiological Association. Orange County, California. 1992 "Recent advances in interventional neuroradiology". Visiting Professor University of Michigan Medical Center. Grand Rounds. Ann Arbor, Michigan. 1992 "Recent advances in the field of Interventional Neurovascular Radiology." Endovascular Symposium. San Jose, California. 1993 "Interventional neurovascular treatment of traumatic Visiting Professor vascular injuries". Vanderbilt University School of Medicine. Grand Rounds. Nashville, Tennessee. 1994 "Interventional neurovascular techniques in stroke therapy." Lawrence Livermore Research Laboratories. Livermore, California. 1995 "Interventional neuroradiology in acute stroke therapy". Visiting Professor Cleveland Clinic Medical Center. Neuroradiology and Neurosurgery Grand Rounds. Cleveland, Ohio. 1996 "Interventional neuroradiology in acute stroke therapy management." Northern California Vascular Surgical Society Meeting. San Francisco, California. 1996 "Endovascular approach to managing stroke". Visiting Professor Symposium on Stroke Prevention. Honolulu, Hawaii 1996 "Recent advances in acute ischemic stroke". St Agnes Visiting Professor Medical Center Stroke Symposium. Fresno, California 1996 "Interventional treatment of acute stroke". Baptist Visiting Professor Medical Center. Grand Rounds. Memphis, Tennessee. 1996 "Thrombolysis for Acute Ischemic Stroke". Vascular Visiting Professor Diseases: Current Management. Temple University School of Medicine. 1996 "Acute Stroke Therapy Interventions". West Virginia Visiting Professor School of Medicine. Grand Rounds. Morgantown, West Virginia. 1996 "Interventional treatment of acute ischemic stroke: Visiting Professor Cerebral Angioplasty & Thrombolysis." Symposium on prevention and management of Stroke. Straub Foundation Hospital. Honolulu, Hawaii. 1996 "Interventional neurovascular treatment options for Visiting Professor treating stroke". Orange County Radiological Association. Orange County, California. 1996 "Endovascular approach to management of acute Visiting Professor stroke". Stroke Symposium. Honolulu, Hawaii. 1996 "Interventional approaches to acute ischemic stroke". Visiting Professor

49 of 193 Prepared: October 27, 2015

Parkersberg Community Hospital. Acute Stroke Symposium. Parkersberg, West Virginia. 1997 "Endovascular approach to cerebral atherosclerosis: Visiting Professor Brachiocephalic Angioplasty". Advanced Coronary and Peripheral Interventions. Fountain Valley, California. 1997 "Recent advances in interventional neuroradiology". Visiting Professor Radiology, Neurology, Neurosurgery Grand Rounds. Sutter General Hospital. Sacramento, California 1997 "Endovascular treatment of cerebrovascular diseases". Visiting Professor Gainey Lecturer on Cerebrovascular Disease. Distinguished Visiting Professor. Mayo Clinic. Rochester, Minnesota. 1997 "Recent advances in acute ischemic stroke Visiting Professor interventions". California Pacific Medical Center. Grand Rounds. San Francisco, California 1997 "Advances in the interventional treatment of acute Visiting Professor stroke." Neuroscience's Conference. San Luis Obispo, California. 1998 "The use of stents in extracranial and intracranial cerebral vascular disease." Cerebrovascular Conference. Fremont, CA. 1998 "Recent advances in acute stroke therapy and Visiting Professor interventions". Stroke Conference. St. Louis, Missouri. 1998 "Acute stroke therapy interventions: Intra-arterial Visiting Professor thrombolytic therapy". Indiana University School of Medicine. Indianapolis, Indiana 1998 "Interventional techniques in acute stroke therapy." Visiting Professor Clinical Research in Stroke. San Francisco, California. 1998 "Interventional treatment for stroke: Thrombolysis, Co-Chair Angioplasty, and Stenting." Clinical Neurosciences by the Bay. San Francisco, California. 1999 "Recent advances in Acute Stroke Therapy Visiting Professor Interventions". Kaiser Medical Center Stroke Conference. Berkeley, California. 1999 "Recent advances in acute stroke therapy"; Visiting Professor "Thrombolytic therapy"; "Carotid Artery Stenting". Sierra Nevada Memorial Hospital. Sierra, Nevada 1999 "Advances in acute stroke therapy and interventions". Visiting Professor Doctor's Hospital of Manteca. Grand Rounds. Manteca, California 1999 "Carotid artery stenting: Techniques and results". Visiting Professor Sequoia Redwood City Medical Center. Grand Rounds. Redwood City, California 2000 "Carotid artery angioplasty and stenting". Los Angeles

50 of 193 Prepared: October 27, 2015

Radiological Society Annual Scientific Session. Los Angeles, California. 2000 "Carotid artery stenting"; Recent advances in Visiting Professor neurointerventional radiology"; "Complex Neurovascular Cases"; Baylor University Medical Center. Grand Rounds. Houston, Texas. 2000 "Intra-arterial thrombolysis in acute ischemic stroke." Stroke Symposium. Los Angeles, California. 2000 "Carotid Artery Stenting". Northern California Vascular Surgical Society. Scientific Symposium. San Francisco, California. 2000 "Cerebral protection techniques for carotid artery stenting". Cerebrovascular Conference. Santa Rosa, California. 2000 "Endovascular techniques in carotid artery stenting". Northern California Surgical Society. Redwood City, California. 2000 "Interventional treatment of carotid and cerebral Visiting Professor atherosclerosis". Cerebrovascular Symposium. Sunnyvale, California. 2000 "Carotid Stenting without Distal Protection: Techniques Visiting Professor and Results"; "Carotid Stenting: Cost/Benefit: Should Asymptomatic Patients be Stented". Stanford Vascular Symposium 2000: Frontiers in Vascular Disease. Pebble Beach, California. 2000 "Advances in the field of Acute Stroke Therapy". Stroke Symposium. Salt Lake City, Utah. 2001 "Advances in Endovascular Interventions". Neuroscience Visiting Professor Symposium. Bakersfield, California. 2001 "Establishing a Successful Neuro Interventional Practice". Interventional Neuroradiology Symposium". Fremont, California. 2001 "Intracranial angioplasty and stenting". Vascular Imaging Visiting Professor Conference. Honolulu, Hawaii 2001 "Endovascular Treatment of Intracranial Cerebral Visiting Professor Aneurysms". Endovascular and Stroke Symposium". Sunnyvale, California. 2002 "Carotid Artery Stenting: An Alternative to Traditional Visiting Professor Carotid Artery Surgery?" Beth Israel New England Medical Center. Department of Anesthesiology & Medicine. Boston, Massachusetts. 2002 "Advances in the endovascular treatment of complex Visiting Professor aneurysms". Northern California Stroke Symposium. Oakland, California

51 of 193 Prepared: October 27, 2015

2002 "Recent advances in the Interventional Treatment of Visiting Professor Acute Ischemic Stroke". St. Vincent's Medical Center. Acute Stroke Interventions Symposium. Santa Fe, New Mexico. 2002 "Interventional Approach to Carotid Atherosclerosis"; "Advances in the Endovascular Treatment of Cerebral Aneurysms". Northern California Vascular Surgical Society. San Francisco, California. 2002 "Endovascular treatment of carotid atherosclerosis: Visiting Professor Stenting & Angioplasty". Endovascular Symposium. Santa Fe, New Mexico. 2002 "Subclavian and Carotid Artery Stenting: Endovascular Visiting Professor Therapy. William Beaumont Medical Center. Interventional Symposium. Royal Oak, Michigan. 2002 "Establishing a Successful Endovascular Neurosurgical Practice". Endovascular Neurosurgical Symposium. Fremont, California. 2002 "Endovascular Treatment of Intracranial Cerebral Aneurysms: Are We As Good As Neurosurgery?" Interventional Neuroradiology Conference. Redwood City, California. 2002 "Recent Advances in Carotid Artery Stenting". Salinas Visiting Professor Valley Memorial Medical Center. 2002 "The Politics of Carotid Artery Stenting". A Practical Visiting Professor Course on Carotid Artery Stenting. Hoag Memorial Hospital. Newport Beach, California. 2002 "Acute Cerebrovascular Rescue". A Practical Course on Visiting Professor Carotid Artery Stenting. Southern California Endovascular Conference, Orange, California. 2002 "Advances in the treatment of ischemic and hemorrhagic Visiting Professor stroke". Sutter Memorial Hospital. Grand Rounds. Sacramento, California. 2002 "Carotid Artery Stenting: Are We As Good As Vascular Visiting Professor Surgery?" Stanford University Medical Center. Grand Rounds. Palo Alto, California 2003 "Interventional Treatment of Intracranial Aneurysms". Visiting Professor Salinas Valley Medical Center: Salinas, California. 2003 "Establishing a Successful Endovascular Practice". Interventional Neuroradiology Symposium. Fremont, California. 2003 "Advances in acute ischemic stroke: Thrombolytic Visiting Professor therapy". St. Paul Minneapolis Medical Center. Grand Rounds. Minneapolis, Minnesota. 2003 "Endovascular Treatment of Cerebral Aneurysms: A Comparison of Surgical vs. Endovascular Results".

52 of 193 Prepared: October 27, 2015

Cerebrovascular Workshop. San Jose, California. 2003 "Recent advances in acute ischemic stroke therapy". Visiting Professor Northern Carolina Medical Society. North Carolina. 2003 "Interventional Approach to Stroke Treatment". Visiting Professor Neurosciences Conference. Greensboro, North Carolina. 2003 "Endovascular Surgical Treatment of Cerebral Visiting Professor Aneurysms". Wake Forest Medical Center. Wake Forest, North Carolina. 2004 "The need for acute interventional stroke trials". Acute Ischemic Stroke Symposium. South San Francisco, California. 2004 "Current Status of Carotid Artery Stenting". Enloe Visiting Professor Medical Center. Chico, California. 2004 "Recent advances in acute ischemic stroke therapy: Visiting Professor Thrombolytic Therapy". St. Mary's Medical Center. Stroke Symposium. Saginaw, Michigan. 2004 "Rescue Treatment for Carotid Artery Stenting". Fourth Visiting Professor Annual Meeting of the Conference. San Francisco, California. 2004 "Recent advances in the diagnosis of stroke". Midwest Visiting Professor Stroke Society. Saginaw, Michigan. 2004 "Interventional Neuroradiology in Interventional MR Applications. Forum on Interventional MRI Techniques. Lawrence Livermore National Laboratories. San Francisco, 2004 "Advances in the interventional treatment of acute Visiting Professor ischemic stroke". Stroke Symposium. Knoxville, Tennessee. 2005 "Recent Advances In Thrombolytic Therapy in Acute Visiting Professor Stroke"; "Current Status of Carotid Artery Stenting". Utah Valley Regional Medical Center. Provo, Utah. 2005 "Recent advances in carotid artery stenting". St. Mary's Visiting Professor Medical Center. Grand Rounds. San Francisco, California. 2006 "Recent advances in the diagnosis and treatment of Visiting Professor acute ischemic stroke". Queen's Medical Center. Honolulu, Hawaii. 2006 "Use of Bare Metal Coils For The Treatment Of Cerebral Aneurysms". Symposium On Interventional Neuroradiology. San Diego, California. 2006 "Advances in the endovascular treatment of hemorrhagic Visiting Professor stroke". Hawaii Neurosurgical Society. Honolulu, Hawaii

53 of 193 Prepared: October 27, 2015

2006 "Recent advances in imaging and carotid artery stenting". Visiting Professor John Muir Medical Center. Grand Rounds. Oakland, California 2006 "Recent advances in acute ischemic stroke". St. Rose Visiting Professor Medical Center. Grand Rounds. Hayward, California 2007 "Interventional Therapies for Acute Ischemic Stroke". Visiting Professor Stroke Symposium Presentation. Santa Rosa, California. 2007 "Recent advances in imaging and the treatment of acute Visiting Professor stroke". Tufts-New England Medical Center. Grand Rounds. Boston, Massachusetts. 2007 "Recent Advances In Acute Ischemic Stroke: Treatment Visiting Professor and Diagnosis". John Muir Medical Center. Grand Rounds. The Donald Sterns Memorial Lecture. Walnut Creek, California. 2007 "Endovascular Techniques For The Treatment Of Acute Visiting Professor Ischemic Stroke". Stroke Symposium Presentation. Santa Rosa, California. 2007 "Recent Advances In Imaging & The Treatment of Acute Visiting Professor Ischemic Stroke". Symposium On Acute Ischemic Stroke. St. Mary's Medical Center. Saginaw, Michigan. 2007 "Recent Advances In Acute Ischemic Stroke". Visiting Professor Neurology Regional Symposium. St. Agnes Medical Center. Fresno, California. 2007 "Recent Advances in the Diagnosis and Treatment of Visiting Professor Acute Ischemic Stroke". John Muir Medical Center. Concord, California. 2007 "Technical Aspects of Intra-Arterial Thrombolysis In Acute Ischemic Stroke". Symposium on Intra-Arterial Thrombolysis. Los Angeles, California. 2007 "Recent advances in imaging and the treatment of acute Visiting Professor ischemic stroke". Tufts-New England Medical Center. Stroke Symposium. Boston, Massachusetts. 2007 "Technical aspects of intra-arterial thrombolysis". Stroke Symposium. Los Angeles, California 2007 "Recent advances in the diagnosis and treatment of Visiting Professor cerebral atherosclerosis". Novato Medical Center. Novato, California 2007 "Advances in the treatment of acute ischemic stroke". Visiting Professor Marin General Hospital. Grand Rounds. Marin, California 2008 "Advances in the Treatment of Acute Ischemic Stroke". Visiting Professor St. Joseph's Medical Center. Stockton, California. 2008 "Treatment of cerebral artery aneurysms". Interventional Visiting Professor

54 of 193 Prepared: October 27, 2015

Neuroradiology Symposium. Salt Lake City, Utah. 2008 "Recent advances in the endovascular treatment of cerebral aneurysms". Neurosurgery Symposium. Napa Valley, California 2009 "Recent advances in the diagnosis and treatment of Visiting Professor acute ischemic stroke". St. Francis Medical Center. San Francisco, California 2011 "Endovascular Treatment of Complex Wide Neck Visiting Professor Aneurysms Using the Enterprise Stent"; "Complication Management of Endovascular Aneurysm Therapy". Neuro Endovascular Aneurysm Summit Meeting. San Jose, California.

CONTINUING EDUCATION COURSES ATTENDED 1985 Japanese Congress of Neurosurgery, Nagoya, Japan 1986 XIII Symposium Neuroradiologicum, Stockholm, , 1987 The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, 1989 17th International Congress of Radiology, Paris, France, 1990 14th International Symposium Neuroradiologicum. London, England. 1995 20th International Joint Conference on Stroke and Cerebral Circulation. 1998 American Heart Association. 23rd International Joint Conference on Stroke and Cerebral Circulation 1999 Annual Meeting of the European Society of Neuroradiology. Vienna, Austria. 2000 The 4th International Conference on Acute Ischemic Stroke. Melbourne, Australia. 2003 Annual Scientific Meeting of the American Society of Neuroradiology. Washington, DC. 2003 Japanese Endovascular Interventions Symposium. Nagoya Japan. 2003 Scientific Session of the 4th Annual Pan Pacific Asian Neurosurgical Congress. Honolulu, Hawaii. 2003 The American Society of Interventional and Therapeutic Neuroradiology First Annual Practicum. Washington, DC. 2003 Annual Meeting of the Society of Neurosurgical Anesthesia and Critical Care. San Francisco, California. 2003 Society of Vascular Medicine. Annual Scientific Meeting. Chicago, Illinois. 2003 World Federation of Interventional and Therapeutic Neuroradiology, Scientific Meeting. Recife, Brazil. 2003 International Symposium on Stroke. Tokyo, Japan. 2003 Global Endovascular Therapies Conference. Seoul, Korea. 2004 Interventional Radiology Research Conference. Bethesda, Maryland. 2004 Annual Meeting of the Joint Section of Cerebrovascular Neurosurgery and American

55 of 193 Prepared: October 27, 2015

Society of Interventional and Therapeutic Neuroradiology. San Diego, California. 2004 Annual Meeting of the Australasian Society of Interventional Neuroradiology. Bangkok, Thailand. 2004 Tiantan International Stroke Conference, Peoples Republic of China. Beijing, China. 2004 5th World Stroke Congress. Annual Scientific Meeting. Vancouver, Canada. 2004 Beijing Neurosurgical Forum. Beijing, China. 2004 Annual Meeting of the Korean Society of Interventional Neuroradiology. 2005 Annual Meeting of the American Society of Interventional & Therapeutic Neuroradiology and the Joint Council of Cerebrovascular Neurosurgery. New Orleans, Louisiana 2005 The 6th International Congress on Minimally Invasive Neurosurgery. Nagoya, Japan. 2005 Japanese Endovascular Neurosurgery Working Group. Nagoya, Japan. 2005 Summer in Seattle 2005. 5th Annual Meeting. Seattle. Washington. 2005 The Second Annual Meeting of the American Society of Interventional & Therapeutic Neuroradiology. Oahu, Hawaii. 2005 Asia Pacific NeuroInterventional Radiology Consensus Meeting. Hanoi, Vietnam. 2005 South American Congress of Neurosurgery. Lima, Peru. 2005 The Japanese Annual Congress of Neurosurgery. Tokyo, Japan. 2005 Japan Endovascular Neurosurgery Symposium. Tokyo, Japan. 2005 World Federation of Interventional & Therapeutic Neuroradiology. Annual Scientific Meeting. Venice, Italy. 2005 Indo-U.S. Symposium On Cerebrovascular Disorders. The Indo-U.S. Science & Technology Forum. India Habitat Centre, New Delhi, India. 2007 The Asian-Oceanic International Symposium of Head and Neck Radiology. Special Symposium on Intracranial Stenting. Singapore. 2007 13th World Federation of Neurosurgery Meeting & 12th Asian Association Congress of Neurosurgery. 2008 8th Annual Asia Pacific Congress of Cardiovascular & Interventional Radiology. Kuala Lumpur, Malaysia. 2008 6th World Stroke Congress. Vienna, Austria. 2010 Third International Neurology Symposium. Santiago, Chile. 2010 7th China Forum on Cerebrovascular Diseases. Beijing, China. 2011 The Asian Oceanian Conference on Cerebrovascular Disease. Shanghai, China. 2011 The XXth World Congress of Neurology. Marrakesh, Morocco. 2012 The 10th International Conference on Cerebrovascular Surgery. Beijing, China. 2012 8th World Stroke Congress, Brasilia, Brazil. 2014 Society of Neurointerventional Surgery Stroke Symposium 2014 2nd Annual International Stroke Symposium, Santiago, Chile

56 of 193 Prepared: October 27, 2015

2014 The Society of Neuro Interventional Surgery, Colorado Springs, Colorado

GOVERNMENT AND OTHER PROFESSIONAL SERVICE 1995 - 2008 American Heart Association Strategic Planning Committee; Chair: Cardiovascular Radiology and Interventions Council; Chair: Interventional Neuroradiology Committee; Clinical Practice Guidelines Committee; 1995 - 2005 National Institutes of Health Neurological Division Consultant and Data Safety and Monitoring Board 1996 - 2005 American Heart Association Stroke Council Advisory Committee & Writing Group Member 1997 - 1998 World Congress on Cerebral Embolism Board of Governor's 2000 - 2002 National Stroke Association Expert Stroke Panel Executive Task Force 2001 - 2002 National Institutes of Health Neurological Division Executive Committee for the Stroke Progress Group 2006 - 2010 U.S. Food & Drug Administration: Neurological Consultant Devices Panel 2009 - present American Medical Foundation for Peer Review Consultant and Education 2010 - 2015 U.S. Food & Drug Administration: Neurological Physician Advisory Panel Devices Panel Member

UNIVERSITY AND PUBLIC SERVICE

UNIVERSITY SERVICE UC SYSTEM-WIDE 1990 - 1992 Insurance Mediation Committee: San Francisco Committee Member Medical Society 1995 - 2005 Lawrence Livermore Laboratories Center for External Panel of Experts in Healthcare Technologies Cerebrovascular Diseases

UCSF CAMPUS-WIDE 1993 - 1995 Clinical Care Task Force Committee Committee Member 1993 - 1995 Committee on Clinical Contracting for Committee Member Neurosurgical Procedures: Kaiser Hospital 1994 - 1996 Stereotactic Gamma Knife Pricing Committee Committee Member 1994 - 1995 Neurosurgery Package Pricing Committee Committee Member

57 of 193 Prepared: October 27, 2015

2003 - 2005 Aneurysm Foundation Founding Member 2012 - 2015 Mission Bay Peri-procedural, Interventional, and Committee Member Procedureal Services Transition Committee

SCHOOL OF MEDICINE 1992 - 1993 Department of Anesthesiology Search Committee for Chief of Neuro Anesthesia 1994 - 1995 Department of Neurology Search Committee for Chief of Neuro Intensive Care Unit 1994 - 1995 Department of Neurosurgery Search Committee for Chief of Vascular Neurosurgery 1994 - 2000 Cerebrovascular Stroke Committee Executive Committee 1998 - 1999 Clinical Neurosciences By The Bay Conference Program Co-Chair 2001 - 2002 Department of Neurology Faculty Research Support Committee 2001 - 2002 Department of Neurology Search Committee for Endowed Chair in Neuro Critical Care 2002 - 2006 Neurosciences AVM Oversight Committee Executive Steering Committee 2003 - 2008 Neurosciences Advisory Committee Executive Planning Committee 2004 - 2005 Department of Neurosurgery Search Committee for Cerebrovascular Neurosurgery 2004 - 2006 Credentials Committee Carotid Artery Stenting Committee 2005 - 2008 Cerebrovascular Interdisciplinary Committee Executive Planning Committee 2008 - present International Services Speakers Bureau 2005 - present Neurosciences Operations Council Executive Planning Committee 2007 - present Neurosciences Service Line Executive Strategic Planning Committee 2010 - present Mission Bay Task Force Peri-Operative Planning Committee 2010 - present Stroke Task Force Committee Committee Member 2010 - present Mission Bay Task Force for Neuro Interventional Committee Member Radiology 2010 - present Telemedicine/Stroke Committee Executive Steering Committee 2012 - 2015 Neuro Interventional Multi-disciplinary Biplane Committee Member

58 of 193 Prepared: October 27, 2015

Angiography & Neurosurgical Suite Design Committee, Mission Bay 2012 - present Clinical Performance Improvement Committee INR Champion for Carotid Artery Stenting 2014 - 2015 Neuro Interventional Design Committee for Hybrid Committee Member MRI/Angio Suite Committee

DEPARTMENTAL SERVICE 1987 - 1988 Neuroradiology Search Committee For Junior Committee Member Faculty 1988 - 1989 Search Committee for Financial Coordinator Committee Member 1989 - 1992 Finance and Billing Committee Committee Member 1991 - 1992 Administration Task Force Advisory Committee Committee Member 1992 - 1994 Quality of Patient Care Committee Committee Member 1993 - 1994 Clinical Care Task Force Committee Committee Member 1998 - 2000 Interventional Magnetic Resonance Imaging Task Committee Member Force 1996 - present Radiology Executive Committee Section Chief: Interventional Neuroradiology 2008 - present UCSF Radiology and Biomedical Imaging: Image Committee Member Guided Therapy Working Group 2008 - present Junior Faculty Mentoring Committee Committee Member 2009 - present Neurovascular and Neuro Interventional Research Committee Member Interest Group 2012 - present Seminars For Section Leaders Committee Member 2014 - 2014 Working Group On Job Satisfaction in Radiology Committee Member 2013 - 2015 Image Guided Therapy Research Group Committee Member 2014 - 2015 Interventional MRI and Angiography Research Committee Member Group

PUBLIC SERVICE 1996 - 1998 University of Southern California Fund Raising to Support Undergraduate Programs 2000 - 2002 Tulane University School of Medicine Fund Raising to Support 2006 - 2008 Hawaii Stroke Society Community Stroke Awareness Programs 2008 - 2013 Central Peninsula Church Community Service and Outreach Programs

59 of 193 Prepared: October 27, 2015

2009 - 2010 Asian Health Institute Community Awareness Programs 2009 - 2012 South Bay Community Outreach Program Community Service

2008 - 2009 Brown University Outreach Programs Fund Raising for University Sponsored Foreign Programs 2009 - 2011 National Lymphoma and Leukemia Foundation Fund Raising for Foundation Activities 2004 - present National Stroke Association Stroke Awareness Campaign 2004 - present American Heart Association Fund Raising and Community Awareness Programs 2005 - present American Stroke Association Fund Raising; "Get With The Guidelines" Program for Community Stroke Awareness" 2009 - present Prince of Peace Foundation Fund Raising To Support Orphanages in China 2014 - 2014 Society of Neurointerventional Surgery Stroke Co-Director Symposium

SUMMARY OF SERVICE ACTIVITIES

Dr. Randall Higashida has been active in international, national, regional, and university service activities. He has served as the past president, president-elect, and vice-president of the Society of Neuro-Interventional Surgery (SNIS), the national organization which represents the specialty of Interventional Neuroradiology and Endovascular Neurosurgery and was on the executive steering committee for 5 years.

Dr. Higashida has also served as the past chairman of the American Heart Association (AHA) Council on Cardiovascular Radiology and Interventions; past chairman of the American Heart Association Council on Interventional Neuroradiology; executive committee of the Joint Section of Cerebrovascular Neurosurgery; executive committee of the American Society of Neuroradiology (ASNR); Data Safety and Monitoring Board of the National Institutes of Health (NIH) Carotid Revascularization by Endarterectomy vs. Stenting Trial; and currently serves on the U.S. FDA Neurological Devices Panel.

Dr. Higashida has been involved on the organizing committees for the 8th International Interdisciplinary Cerebrovascular Symposium in Shanghai, China; the XXth World Congress on Neurology in Marrakesh, Morocco; the World Federation of Interventional & Therapeutic Neuroradiology International Advisory Committee; the UCSF Neurosciences Steering Committee; and multiple writing groups of the American Heart Association and American Stroke Association for Guidelines and Standards of Care, which are published as national and

60 of 193 Prepared: October 27, 2015

international practice guidelines for hospitals and physicians worldwide.

Dr. Higashida has also served on the Editorial Board for 15 peer reviewed medical journals including the Journal of Endovascular Surgery, American Journal of Neuroradiology, International Journal for Minimally Invasive Neurosurgery, Journal of Neuro Imaging, Journal of Vascular and Interventional Radiology, Cerebrovascular Diseases, Neurosurgery, Minimally Invasive Surgery, Interventional Neurology, World Journal of Radiology, and the International Journal of Stroke. In addition Dr. Higashida serves as a manuscript reviewer for 12 additional scientific journals including the New England Journal of Medicine, Stroke, Radiology, Neurology, Cochrane Stroke Group, Health Policy Journal, and Expert Review of Neurotherapeutics. Dr. Higashida has been awarded recognition as a top manuscript reviewer in many of these journals including the American Journal of Neuroradiology and the Journal of Vascular and Interventional Radiology.

TEACHING AND MENTORING

TEACHING

POSTGRADUATE AND OTHER COURSES 1987 - "Interventional Neuroradiology: Lectures in Diagnostic Angiography Applications and techniques". Neuro and Interventional Neuroradiology Diagnostic Imaging Seminars: MRI, Neuro Interventional, and CT. UCSF Post-Graduate Course. San Francisco, California 1987 - "Percutaneous transluminal angioplasty Lectures in Diagnostic Angiography of brachiocephalic vessels"; "Pre- & Interventional Neuroradiology Operative treatment of head and neck tumors by interventional therapy". UCSF Diagnostic Radiology Seminars. Maui, Hawaii. 1987 - "Percutaneous transluminal angioplasty Lectures in Diagnostic Angiography of extracranial lesions". Thirteenth and Interventional Neuroradiology Annual Post-Graduate Course in Diagnostic Radiology. San Francisco, California. 1988 - "Clinical advances in interventional Lectures in Diagnostic Angiography neuroradiology". UCSF Conference on and Interventional Neuroradiology Cerebrovascular Diseases. 1988 - "Treatment of carotid cavernous sinus Lectures in Diagnostic Angiography fistulas by interventional radiology and Interventional Neuroradiology techniques". UCSF Grand Rounds. 1988 - "Endovascular techniques to treat Lectures in Diagnostic Angiography carotid cavernous sinus fistulae". UCSF and Interventional Neuroradiology Neurosurgical Grand Rounds.

61 of 193 Prepared: October 27, 2015

1989 - "Arteriovenous malformations: Lectures in Diagnostic Angiography Diagnosis, Management, and Therapy"; & Interventional Neuroradiology "Treatment of intracranial aneurysms by interventional neurovascular techniques"; Percutaneous transluminal angioplasty of brachiocephalic vessels". Diagnostic Radiology Seminars. Ixtapa, Mexico. 1989 - "Management of of Galen Lectures in Diagnostic Angiography Malformations in the Neonate". UCSF and Interventional Neuroradiology Neuroradiology Grand Rounds. 1989 - "Treatment of complex intracranial Lectures in Diagnostic Angiography aneurysms by interventional and Interventional Neuroradiology techniques". 32nd Annual Post- Graduate Course in Diagnostic Radiology. San Francisco, California. 1989 - "Management of intracranial arterial Lectures in Diagnostic Angiography vasospasm: Medical and radiological and Interventional Neuroradiology aspects of therapy". UCSF Neurosurgery Grand Rounds. 1989 - "Cerebrovascular occlusive disease: Lectures in Diagnostic Angiography Angioplasty and neurosurgical and Interventional Neuroradiology considerations". UCSF Contemporary Course in Neurosciences Conference. San Francisco, California. 1990 - "Recent advances in interventional Lectures in Diagnostic Angiography neuroradiology". UCSF Radiology and Interventional Neuroradiology Grand Rounds. 1992 - "Transluminal angioplasty for vascular Lectures in Diagnostic Angiography lesions of the head and neck". UCSF and Interventional Neuroradiology Post-Graduate Radiology Conference. 1993 - "Advances in Interventional Lectures in Diagnostic Angiography Neuroradiology". UCSF Symposium on and Interventional Neuroradiology Interventional Magnetic Resonance Imaging. San Francisco, California. 1995 - "Endovascular therapy for prevention of Lectures in Diagnostic Angiography acute stroke". UCSF Vascular Surgery and Interventional Neuroradiology Grand Rounds. 1996 - "Recent advances in acute stroke Lectures in Diagnostic Angiography therapy interventions". UCSF and Interventional Neuroradiology Neuroradiology Grand Rounds. 1997 - "Recent advances in endovascular Lectures in Diagnostic Angiography therapy of complex vascular lesions". and Interventional Neuroradiology UCSF Annual Course for Nurses and Technologists. 1997 - "Technical advances in stroke Lectures in Diagnostic Angiography interventions". UCSF and Interventional Neuroradiology

62 of 193 Prepared: October 27, 2015

Conference. San Francisco, California. 1998 - "Interventional techniques in acute Lectures in Diagnostic Angiography stroke therapy". San Francisco and Interventional Neuroradiology Veteran's Affairs Medical Center. Grand Rounds. 1998 - "Thrombolysis, angioplasty, and stenting Lectures in Diagnostic Angiography for cerebral stroke". UCSF Clinical and Interventional Neuroradiology Neurosciences Conference. 1998 - "Recent advances in the therapy of Lectures in Diagnostic Angiography acute ischemic stroke". UCSF Clinical and Interventional Neuroradiology MRI Symposium 1999 - "Interventional therapy for acute Lectures in Diagnostic Angiography ischemic stroke: Angioplasty and and Interventional Neuroradiology Stenting Techniques". UCSF Cerebrovascular Stroke Conference. San Francisco, California 1999 - "Endovascular therapy of extracranial Lectures in Diagnostic Angiography and intracranial lesions". UCSF and Interventional Neuroradiology Neurology Grand Rounds 2001 - "Interventional therapy of complex Lectures in Diagnostic Angiography intracranial vascular lesions". UCSF and Interventional Neuroradiology Radiology Grand Rounds 2001 - "Assessment, risk factors, and treatment Lectures in Diagnostic Angiography of acute ischemic stroke"; "Intracranial and Interventional Neuroradiology angioplasty and stenting for acute stroke intervention: When medical therapy fails"; "Management and assessment of vascular injuries to the head and neck". Vascular Imaging In Hawaii Seminars. Kona, Hawaii. 2002 - "Peri-Operative risk factors in carotid Lectures in Diagnostic Angiography artery stenting". UCSF Anesthesiology & Interventional Neuroradiology Grand Rounds. 2004 - "Rescue therapy in acute ischemic Lectures in Diagnostic Angiography stroke". UCSF Vascular Surgery Grand and Interventional Neuroradiology Rounds. 2004 - "Interventional therapy applications in Lectures in Diagnostic Angiography MRI scanning". UCSF Radiology MRI and Interventional Neuroradiology Symposium. 2005 - "Current techniques and clinical trials in Lectures in Diagnostic Angiography carotid interventions". UCSF & Interventional Neuroradiology Interventional Radiology Symposium 2007 - "Carotid artery stenting: Techniques, Lectures in Diagnostic Angiography Results, Clinical Trials". UCSF & Interventional Neuroradiology Interventional Radiology Review Course. 2008 - "Carotid Artery Stenting: Current Trials". Lectures in Diagnostic Angiography

63 of 193 Prepared: October 27, 2015

UCSF Neurology Grand Rounds & Interventional Neuroradiology 2010 - "Endovascular therapy of intracranial Lectures in Diagnostic Angiography aneurysms". UCSF Neurosurgery & Interventional Neuroradiology Resident Review Course. 2011 - "A comparison of surgical vs. Lectures in Diagnostic Angiography endovascular therapy for treatment of & Interventional Neuroradiology cerebral aneurysms". "Cerebrovascular pathology". UCSF Neurosurgery Resident Review Course 2012 - "Imaging of acute ischemic stroke". Lectures in Diagnostic Angiography "Essentials of vascular neuro-". & Interventional Neuroradiology UCSF Neurosurgery Resident Review Course 2014 - "Computations Fluid Dynamics To Lectures in Diagnostic Angiography Assess Cerebral Aneurysms"; & Interventional Neuroradiology Advances In Interventional MR Imaging"; "Carotid Artery Stenting For Cerebral Atherosclerosis"; "Endovascular Treatment of Cerebral Aneurysms"; UCSF Neurosurgery, Interventional Neuroradiology, Neurology, Anesthesiology Resident Review Course 2015 - "Endovascular Treatment of Cerebral Lectures in Diagnostic Angiography Aneurysms"; "Interventional & Interventional Neuroradiology Management for Acute Ischemic Stroke"; Advances in Imaging of Acute Brain Disorders"; UCSF Neurosurgery Review Course; Interventional Neuroradiology, Review Course; 2015 - "Angioplasty and Stenting for UCSF Neuro Interventional Cervicocerebral Atherosclerosis". Workshop

INFORMAL TEACHING 1986 - present Interventional neuroradiology and is taught to medical students, residents, and fellows from the departments of Radiology, Neurology, Neurosurgery, Anesthesiology, and from other services, mainly by informal contact in consultation, ward rounds, seminars, demonstrations, and in clinical practice. Dr. Higashida, as Chief of the Interventional Neuroradiology section, is responsible for overseeing the training of 2-3 Interventional Neuroradiology fellows per year, 7-8 diagnostic neuroradiology fellows training in cerebral angiography, and residents in neurosurgery and neurology as well as medical students that rotate through our INR section for 1-4 weeks of block time. The INR section performs more than 1200 diagnostic and therapeutic procedures annually. This involves reviewing with the fellow and/or student each patient case in detail for clinical indications, procedure risks and benefits, and performance standards prior to performing each procedure. Training involves teaching fellows with “hands-on instruction” how to perform each

64 of 193 Prepared: October 27, 2015

phase of the diagnostic angiogram and endovascular procedure. Eventually with enough individual experience, fellows are allowed to perform the majority of each case, under close personal supervision, and make decisions regarding proper selection of treatment algorithms. Each fellow is expected to perform 300-400 cases per year of diagnostic and endovascular procedures under a formal 2 year fellowship. Each case is considered a teaching and learning experience for the clinical fellow and/or student involved. All angiographic films are reviewed in detail for proper diagnosis and treatment. In our weekly combined neurovascular conference with colleagues from stroke neurology, neurosurgery, neuro-anesthesiology, and Ph. D. researchers, Dr. Higashida, along with his colleagues lead the discussion on the diagnosis and approach to the treatment of upcoming complex vascular cases. This includes patients with ruptured brain aneurysms, acute ischemic stroke, and pediatric and neonatal stroke treatment. On average, 5-10 cases are discussed in detail, combining all aspects of presenting symptoms, diagnosis, and planned therapy. Discussion is held with all specialties to evaluate the risks of various treatment plans and options including interventional/endovascular therapy, open brain surgery, radiation treatment, and medical therapy. Many patients are referred to our Ph.D. scientists for further evaluation of their complex brain lesion, to evaluate their long term changes in cerebral aneurysm growth vs. stability, assessment of cerebral perfusion patterns, and for further evaluation of mapping out symptoms to specific underlying vascular etiologies. Informal teaching occupies at least 35% of Dr. Higashida's time. Dr. Higashida spends an average of 5-10 hours per week interacting with neurosurgeons, neurologists, and radiologists in the community through consultations and meetings. Any patient contact is simultaneously a teaching demonstration for medical students, house staff, residents, and fellows.

TEACHING NARRATIVE

Dr. Higashida actively engages in teaching and "hands-on" formal training of both diagnostic cerebral angiography and interventional neuroradiology procedures to fellows and residents on a daily basis through patient procedures. In addition, he has lectured and presented extensively at grand rounds, resident review courses, weekly neurovascular conferences, and annual courses held by radiology, neurosurgery, neurology, vascular surgery, and anesthesiology.

A series of lectures are provided to incoming fellows, residents, and students with an introduction to basic vascular anatomy of the head, neck, brain and spinal cord. This is followed with formal teaching on the assessment and endovascular treatment of patients with acute ischemic stroke, acute hemorrhagic stroke due to ruptured brain aneurysms and arteriovenous malformations, traumatic vascular injuries causing dissection and arterial , and indications for treatment of patients with transient ischemic attack symptoms with extracranial and intracranial atherosclerotic disease. The current indications for therapy, potential risks, and management decisions are discussed, as well as treatment algorithms and surgical alternatives.

65 of 193

(b) (6) Prepared: October 27, 2015

1992 - 1992 University of Tsukubu, Japan

1992 - 1992 Middlebrough Hospital, United Kingdom

1992 - 1992 Okayama Medical University, Japan

1993 - 1993 Kagawa Medicial School, Japan

1993 - 1993 The Radcliffe Infirmary, Oxford, United Kingdom

1993 - 1993 Akita University, Japan

1993 - 1993 Unita Sanitaria Locale, Livorno, Italy

1993 - 1993 Royal Infirmiry, Edinburgh, United Kingdom

1993 - 1993 Ankara, Turkey

1993 - 1993 Turku University Hospital, Finland

1993 - 1993 Okayama University , Okayama, Japan 1993 - 1993 Teikyo University, School of Medicine, Tokyo, Japan

1994 - 1994 Queen Elizebeth Hospital, Honk Kong

1994 - 1994 University of Brescia, Italy

1994 - 1994 University of Tokyo, Japan

1994 - 1994 Chun-Buk National University, Chunju, Korea

1994 - 1994 The National Hospital for Neurology and Neurological Surgery, Queens Square, London, United Kingdom 1994 - 1994 University of Norway

1995 - 1995 Queen Elizebeth Hospital, Kowloon, Hong Kong

1995 - 1995 University of Lisbon, Portgual

1995 - 1995 Kohnan Hospital, Sendai, Japan

84 of 193 (b) (6) Prepared: October 27, 2015

1996 - 1996 Niigata University, Niigata, Japan

1997 - 1997 Chief of Neuroradiology and Endovascular Surgery, Iniversidade Estandual, Rio de Janeiro, Brasil 1999 - 1999 Unita Sanitaria Locale, Rome, Italy

1999 - 1999 The Royal Melboune Hospital, Melbourne, Australia

1999 - 1999 Head of Neuroradiology, Hospital de L'ile, Bern Switerland 2000 - 2000 Nara Medical University, Nara, Japan

2006 - 2006 Aga Khan University Karachi, Pakistan

MENTORING NARRATIVE

Dr. Randall Higashida, as Chief of the Interventional Neuroradiology section since 1996, has spent considerable time and effort for teaching visiting professors and post doctoral students both at UCSF Medical Center and abroad including Germany, France, Great Britain, Italy, China, Japan, South Korea, Hong Kong, Singapore, Australia, Indonesia, Taiwan, Malaysia, Mexico, Argentina, Canda, Brazil, Philippines, and India in these advanced interventional neurovascular procedures. He has lectured extensively, and performed in these countries helping to train interventional neuroradiologists and endovascular neurosurgeons in these techniques through hands on endovascular surgical operations on patients requiring therapy, didactic lectures, and workshops.

The Interventional Neuroradiology fellowship program, is one of the most prestigious and well established programs in the United States and internationally.

At UCSF our group developed one of the first fellowship training programs in the world in 1986, to train physicians with a background in neuroradiology, neurosurgery, and neurology in these advanced minimally invasive techniques for complex brain vascular disorders.

Dr. Higashida wrote and published the first article on training standards for Interventional Neuroradiology/Endovascular Neurosurgery in 2001, and since then, these fellowship training standards have been adopted by the American College of Graduate Medical Education (ACGME), into a formal , as well as being accepted by the Society of Neurointerventional Surgery, the Joint Council of Cerebrovascular Neurosurgery, the American Association of Neurological Surgeons, the Congress of Neurological Surgeons, and the American Academy of Neurology, as training standard guidelines.

Since 1986, at UCSF, more than 150 diagnostic neuroradiology fellows have been trained to perform diagnostic cerebral angiography procedures, and more than 50 interventional neuroradiology fellows have been formally trained in a 2 year fellowship. These fellowship trained physicians have gone on to develop other interventional neuroradiology programs at

85 of 193 Prepared: October 27, 2015 major academic and private hospitals throughout the United States, Canada, Australia, Japan, and Europe, thus fostering and validating the specialty of interventional neuroradiology/endovascular neurosurgery as a subspecialty of neuroradiology, neurosurgery, and neurology.

TEACHING AND MENTORING AIDS

Development of 3D Simulators for Cerebral Angiography and Neuro Interventional Procedures:

Working in conjunction with medical device companies, Dr. Higashida has worked with engineers and software developers to develop 3D models and simulators for helping to train medical students, residents, and fellows to learn both cerebrovascular anatomy, and catheterization skills for cerebral angiography, and interventional neuroradiology procedures.

These simulation devices involve "hands-on" simulation of , guidewires, and various embolic agents, as well as simultaneously producing clinical scenario's for testing various types of medical devices and products. These include simulations of performing diagnostic cerebral angiography, carotid artery stenting, and intracranial access of cerebral artery aneurysms, and coiling procedures.

These simulators have helped in training, teaching, education and practical skills to post- doctorate physicians, residents, fellows, and medical students practical neuro-angiography and neuro-interventional techniques.

Development of Benchtop Models for Simulation:

Working in conjunction with medical device engineers, Dr. Higashida has helped to create benchtop models which mimic the actual human cerebral extracranial and intracranial vasculature. He then helped to create models which simulate different such as cerebral arteriovenous malformations (AVM's), arteriovenous fistulae (AVF's), and brain aneurysms.

86 of 193 Prepared: October 27, 2015

Using these models has helped to train large numbers of fellows and residents, for basic catheter skills in the field of interventional neuroradiology/endovascular neurosurgery. This involves practice simulation for injection of liquid tissue adhesives to occlude cerebral AVM's and AVF's. These models also allow physicians to practice coiling of intracranial arterial aneurysms, and to deploy stents into the cerebral artery circulation, as well as navigation skills under X-ray fluoroscopic visualization.

Development of Animal Models for Neuro Interventional Research:

Dr. Higashida has worked with veterinarians and medical technologists to develop various animal models including rabbits, rats, pigs, and dogs, to create simulations of pathologies such as arteriovenous fistula's and aneurysms. These techniques involve surgically created shunts between the arteries and , and then performing ablation techniques for testing out new devices for pre-human evaluation studies.

These procedures have also been adopted for training post-doctoral fellows and residents for learning these techniques and devices, prior to human use. Dr. Higashida has spent considerable time training physicians from all over the world on these new devices and techniques by overseeing both animal labs and bench-top training of new devices and techniques for neurointerventional therapies, over the past 2 decades.

OTHER

Patient Information Brochures and Website Development

Working in conjunction with the American Heart Association (AHA), the American Stroke Association (ASA), the Society of Neurointerventional Surgery (SNIS), and the American Society of Neuroradiology (ASNR), Dr. Higashida has authored patient information brochures along with a Website to educate the public about the risk of stroke; how to recognize a stroke; early warning signs of a stroke; and what to do in case of an emergency. This brochure is entitled: "What Is A Stroke?".

Dr. Higashida has also authored a second patient information brochure entitled: "What You Should Know About Cerebral Aneurysms". This brochure contains patient information regarding what is a brain aneurysm; what is the risk of from a ruptured aneurysm; what

87 of 193 Prepared: October 27, 2015 are the symptoms of sudden rupture; tests to determine if a patient has a brain aneurysm; and the treatment options for therapy, which include endovascular coiling vs. open brain surgery.

A third patient brochure which Dr. Higashida illustrated and authored is entitled: "What Is An Arteriovenous Malformation (AVM)". This booklet describes what a brain AVM is; what are its causes; the symptoms of an AVM; what is the risk of bleeding from an AVM; how AVM's are diagnosed; and what are the best treatment options.

All three of the illustrated patient brochures are available to hospitals, societies, and the public for distribution to enhance awareness of stroke and cerebrovascular disorders, which is the third leading cause of death and the #1 cause of adult disability in the U.S. These brochures have been widely distributed and are also available on the websites of the above organizations.

SUMMARY OF TEACHING AND MENTORING HOURS 2012 - 2013 750 total hours of teaching (including preparation) Formal class or course teaching hours: 60 hours Informal class or course teaching hours: 290 hours Mentoring hours: 400 hours Other hours:

2013 - 2014 750 total hours of teaching (including preparation) Formal class or course teaching hours: 60 hours Informal class or course teaching hours: 290 hours Mentoring hours: 400 hours

2014 - 2015 750 total hours of teaching (including preparation) Formal class or course teaching hours: 60 hours Informal class or course teaching hours: 290 hours Mentoring hours: 400 hours

2015 - 2016 750 total hours of teaching (including preparation) Formal class or course teaching hours: 60 hours Informal class or course teaching hours: 290 hours Mentoring hours: 400 hours

88 of 193 Prepared: October 27, 2015

RESEARCH AND CREATIVE ACTIVITIES

RESEARCH AWARDS CURRENT 10-01862 (Principal Investigator) 07/2012 - 08/19/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Endovascular Treatment: A Sixteen Year Experience (b) (4) total

10-01162 (Co-Principal Investigator) 2004 - 2016 Stryker Neurovascular Corporation (b) (4) direct/yr1 Neuroform Stent for Treatment of Wide Neck Complex (b) (4) total Intracranial Aneurysms 558744 (Co-Principal Investigator) 02/01/2013 - 02/01/2015 CTSI-RAP Translational Technology Development Grant (b) (4) direct/yr1 Endovascular : Evaluation of technical feasibility of (b) (4) total novel endothelial cell harvesting devices within a rabbit cerebral aneurysm model. 10-03924 (Co-Principal Investigator) 07/01/2013 - 07/01/2016 Radiology and Biomedical Imaging Department Grant (b) (4) direct/yr1 Endovascular Biopsy: Technical Feasibility of endothelial (b) (4) total cell collection using conventional detachable aneurysm coils. 27487 (Co-Principal Investigator) 06/01/2012 - 06/01/2016 The Aneurysm and AVM Foundation (b) (4) direct/yr1 Endovascular Biopsy: Evalution of technical feasibility and (b) (4) total assessment of molecular risk factors within aneurysms 10-02669; H55606-32881-02A (Co-Principal Investigator) 08/23/2012 - 09/24/2016 Codman Neurovascular Corporation (b) (4) direct/yr1 HUD-HDE# 060001: Codman Enterprise Vascular (b) (4) total Reconstruction Device and Delivery System 14-14850 (Co-Principal Investigator) 11/23/2014 - 11/23/2017 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Database for the management of patients with Hereditary (b) (4) total Hemorrhagic (Osler-Weber Rendu Syndrome) 10-00936 (Co-Principal Investigator) 07/2014 - 07/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Endovascular Treatment: A 10 year retrospective study at (b) (4) total the University of California, San Francisco, San Francisco General Hospital, and San Francisco Veteran's Administration Medical Center 14-13302 (Co-Principal Investigator) 07/2013 - 07/2016

89 of 193 Prepared: October 27, 2015

Stryker Neurovascular Corporation (b) (4) direct/yr1 HUD 03-010: Wingspan Stent System with Gateway PTA (b) (4) total Balloon 10-02232 (Co-Principal Investigator) 04/2014 - 04/2016 Stryker Neurovascular Corporation (b) (4) direct/yr1 Neuroform EZ Stent System: HDE# H020002/S0016 (b) (4) total

12-09040 (Co-Principal Investigator) 09/2014 - 09/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Long-term outcomes after Endovascular Treatment of Vein (b) (4) total of Galen Malformations 13-12620; 13087 (Co-Principal Investigator) 1/2014 - 1/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 A Pilot Study Evaluating the Safety of Alternating Systemic (b) (4) total Chemotherapy and Intra-Arterial Melphalan Chemotherapy in Children with Newly Diagnosed Advanced Intra-Ocular Retinoblastoma 10-04632; H10764-35173-01 (Co-Principal Investigator) 11/2013 - 11/2016 Department of Neurosurgery Grant Funding (b) (4) direct/yr1 Brain vascular malformations research network: (b) (4) total Predictors of phenotype and clinical course: Cerebral hemorrhage risk in Hereditary Hemorrhagic Telangiectasia 10-01008 (Co-Principal Investigator) 06/2013 - 06/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Disorders of Cerebral Development: A Phenotypic and (b) (4) total Genetic Analysis 12-10171 (Co-Principal Investigator) 04/2013 - 04/2016 Interventional Neuroradiology Grant Funding (b) (4) direct/yr1 Hemodynamic conditions in arteriovenous malformation (b) (4) total feeding arteries

PENDING 12-10023 (Co-Investigator) 2013 - 2015 Aldagen Pharmaceuticals A Phase 2 randomized controlled trial with a Phase 1 safety cohort testing the safety, feasibility, and outcomes of delivering autologous marrow delivered via intra- arterial infusion in patients who present with a large territory acute ischemic stroke. Pending (Co PI; Data Safety & Monitoring) 2014 - 2016 American Heart Association (b) (4) direct/yr1

90 of 193 Prepared: October 27, 2015

Avastin for treatment of Brain Arteriovenous Malformations (b) (4) total

PAST (Principal Investigator) 1978 - 1979 American Heart Association (b) (4) direct/yr1 Prostaglandins and hypoxia in the cardiopulmonary (b) (4) total circulation of animals. Tulane University School of Medicine New Orleans, LA (Co-Principal Investigator) 1983 - 1984 UCLA Medical Center (b) (4) direct/yr1 Digital Vascular Imaging: James T. Case Radiology (b) (4) total Foundation Research Award: UCLA Medical Center Los Angeles, CA (Co-Principal Investigator) 1984 - 1985 UCLA Medical Center: Department of Radiology (b) (4) direct/yr1 imaging in the Neonate: James T. Case (b) (4) total Radiology Foundation Research Award: UCLA Medical Center Los Angeles, CA (Principal Investigator) 1985 - 1986 UCLA Medical Center: Department of Radiology (b) (4) direct/yr1 Intravascular Embolization Techniques: James T. Case (b) (4) total Radiology Foundation Research Award: UCLA Medical Center, Los Angeles, CA (Co-Principal investigator) 1984 - 1985 University of California Berkeley Center (b) (4) direct/yr1 Development of experimental brain tumor model in (b) (4) total animals. UCLA Medical Center Los Angeles, CA (Principal Investigator) 1991 - 1992 Berlex Medical Research Foundation (b) (4) direct/yr1 Safety, Tolerance, and Diagnostic Efficacy of Iopromide (b) (4) total and Ioversol in patients requiring arteriography by Digital Subtraction Techniques: UCSF Medical Center, San Francisco, CA (Principal Investigator) 1991 - 1992 UCSF Medical Center: Department of Radiology (b) (4) direct/yr1 Development of Intracranial Arterial Aneurysms in an (b) (4) total Animal Model (Co Principal Investigator) 1991 - 1992 Industry Grant (b) (4) direct/yr1 Cooperative Study on the Feasibility and Safety of (b) (4) total Percutaneous Transluminal Angioplasty for Brachiocephalic Disease: National Multicenter Trial

91 of 193 Prepared: October 27, 2015

(Co-Principal Investigator) 1991 - 1994 Toshiba Medical Systems Research Grant (b) (4) direct/yr1 Three dimensional reconstruction of complex (b) (4) total neurovascular disorders: Pilot Study Section Grant (Principal Investigator) 1993 - 1994 Berlex Research Award Grant (b) (4) direct/yr1 Double Blind Comparison of the Safety, Tolerance, and (b) (4) total Diagnostic Efficacy of Iotrolan 280 mgI/ml and Iohexol 300 mgI/ml in patients requiring Cerebral Angiography. Research Award (Principal Investigator) 1993 - 1994 UCSF Medical Center: Department of Radiology (b) (4) direct/yr1 The safety of intra-arterial stents in Canine Cerebral (b) (4) total Aneurysms. Pilot Study Section Grant (Co Principal Investigator) 1993 - 1994 Neurovascular Corporation (b) (4) direct/yr1 Cooperative Study on the Feasibility and Safety of (b) (4) total Percutaneous Transluminal Angioplasty for Brachiocephalic Disease National Multicenter Study Research Award (Co Principal Investigator) 1993 - 1996 Lawrence Livermore National Laboratories Pilot Research (b) (4) direct/yr1 Award Release Mechanisms for NeuroInterventional Radiological (b) (4) total Procedures Lawrence Livermore/U.C.S.F. Medical Center/U.C. Berkeley Cooperative Project (Co Principal Investigator) 1993 - 1994 UCSF Medical Center: Department of Radiology (b) (4) direct/yr1 Development of dural arteriovenous fistulae in rats by (b) (4) total introducing venous hypertension. Departmental Research Grant H6201-12425-03A (National Co-Principal Investigator) 1994 - 1997 Abbott Pharmaceuticals Industry Grant (b) (4) direct/yr1 Intra-Arterial Pro-Urokinase in Acute Middle Cerebral (b) (4) total Artery Thromboembolic Stroke: Multicenter North American Trial: Phase 1/2 Clinical Trial (National Co-Principal Investigator) 1997 - 2001 Abbott Grant (b) (4) direct/yr1 Intra-Arterial Pro-Urokinase in Acute Middle Cerebral (b) (4) total Artery Thromboembolic Stroke: Multicenter North American Trial: Phase 3 Clinical Trial H5570-12787-02 (National Co-Principal Investigator) 1997 - 1998 Cordis Endovascular Corporation (b) (4) direct/yr1

92 of 193 Prepared: October 27, 2015

Carotid Stent Supported Angioplasty Trial; Phase 2 Study (b) (4) total

H8480-12953-02 (Co-Principal Investigator) 1998 - 2000 Target Therapeutics Corporation Treatment of Direct Carotid Cavernous Sinus Fistula's with Detachable Silicone Balloons H5570-12757-03 (National Co-Principal Investigator) 1998 - 2000 Cordis Neurovascular Corporation (b) (4) direct/yr1 A Prospective Randomized Study between Polyvinyl (b) (4) total Alcohol Particles vs. N Butyl Cyanoacrylate for Cerebral Arteriovenous Malformations (Co-Principal Investigator) 1998 - 1999 Cordis Endovascular Corporation (b) (4) direct/yr1 Carotid Artery Stenting SMART Stent Trial (b) (4) total

H6201-17206-04 (National Co-Principal Investigator) 1998 - 2001 Possis Medical Systems, Inc. (b) (4) direct/yr1 TIME 1: Thrombectomey in Middle Cerebral Artery (b) (4) total Embolism H6201-13553-02 (Co Principal Investigator) 1998 - 2000 Target Therapeutics Corporation The Guglielmi Detachable Coil Registry

H8480-12397-03 (Co Principal Investigator) 1999 - 2001 Target Therapeutics Corporation Treatment of Vascular Lesions and Fistula's with Detachable Silicone Balloons H5570-15194-02 (National Co-Principal Investigator) 1999 - 2001 Possis Medical Systems, Inc. (b) (4) direct/yr1 React 1: Reperfusion in Acute Cerebral (b) (4) total Thromboembolism H5570-18846 (National Co-Principal Investigator) 2000 - 2004 Medtronics Medical Corporation (b) (4) direct/yr1 Arterial Vascular Engineering: Intracranial Stent for (b) (4) total Cerebral Aneurysm Trial P01-NS44155-01A (Co-Principal Investigator) 2000 - 2004 National Institutes of Health Integrative of Cerebral Arteriovenous Malformations NIH R01 NS37921-01A1 (Co-Principal Investigator) 2000 - - 2002

93 of 193 Prepared: October 27, 2015

National Institutes of Health Theoretical Modeling of Cerebral Arteriovenous Malformations and the Risk of Rupture NIH R01 NS27713-08 (Co-Principal Investigator) 2000 - 2005 National Institutes of Health Hemodynamic Measurements of Cerebral Arteriovenous Malformations H8480-21295-01 (Co Principal Investigator) 2002 - 2003 UCSF Department Research Grant Endovascular Treatment of Vein of Galen Malformations

H8480-21244-01 (Co Principal Investigator) 2002 - 2004 Boston Scientific Corporation Matrix Detachable Coil System for Cerebral Aneurysm Occlusion H5570+20186-01B (Co Principal Investigator) 2002 - 2004 Ekos Corporation Stroke Thrombolysis with Ultrasound Acceleration

NIH R01 NS34949-05 (Co-Investigator) 2002 - 2005 National Institutes of Health Predictors of Spontaneous Cerebral Arteriovenous Malformation Hemorrhage (Co-Principal Investigator) 2004 - 2006 National Institutes of Health $50,000.00 direct/yr1 Hemorrhagic Diseases of the Brain Cohort Research $100,000 total Study Group: William L. Young PI, Research Award for Pilot Funding by UCSF Medical Center H5570-18846 (National Principal Investigator) 2001 - 2005 Medtronics Medical Corporation (b) (4) direct/yr1 Carotid Artery Stenting Trial: AVE/Medtronic: Maveric Trial (b) (4) total

H5 R01 NS39160, H5570-15625-04 (Co-Principal 2002 - 2006 Investigator) National Institutes of Health $5,000.00 direct/yr1 Interventional Management of Stroke (IMS Trial): NIH $15,000.00 total Sponsored Multi Center Study for Acute Ischemic Stroke H5570-19980-02 (Principal Investigator) 2001 - - 2006 Perclose/Abbott Pharmaceuticals Corporation (b) (4) direct/yr1

94 of 193 Prepared: October 27, 2015

SECuRITY Trial: A registry study to evaluate the (b) (4) total Neuroshield BareWire Cerebral Protection System and the Xact Stent in Patients at High Risk for Carotid Endarterectomy. H10764-17619-02 (Co-Principal Investigator) 2001 - - 2005 National Institutes of Health The Interaction of Vascular Wall Protein Genotype on Outcome in Cerebral Hemorrhagic Disease (Co Principal Investigator) 2001 - 2004 Industry Sponsored Research Grant The Regulation of Human Cerebral Blood Flow by Nitric Oxide Following Percutaneous Transluminal Angioplasty of Cervical Arterial Stenosis H6201-24885-02 (Co-Principal Investigator) 2003 - 2006 Cordis Neurovascular Corporation (b) (4) direct/yr1 Use Of A Humanitarian Use Device for Treatment of Wide (b) (4) total Necked Cerebral Aneurysms: Enterprise Intracranial Stent

(Co-Principal Investigator) 2003 - 2006 Industry Sponsored Research Grant (b) (4) direct/yr1 The Effect of Tetracycline-Derivatives on Collagens (b) (4) total Activity in patients with Inoperable Brain Arteriovenous Malformations, Inoperable Giant Aneurysms, and AVM Patients having Undergone Gamma Knife Radiosurgery (Co-Principal Investigator) 2003 - 2006 Boehringer-Ingelheim Pharmaceuticals International, (b) (4) direct/yr1 Germany Use of Aggrenox In Preventing Recurrent In-Stent (b) (4) total Stenosis H5570-18907-02 (Co Principal Investigator) 2003 - 2005 Concentric Medical Systems (b) (4) direct/yr1 MERCI Phase I: A prospective, non-randomized (b) (4) total evaluation of the CONCENTRIC Retriever System for the treatment of neurovascular thrombotic occlusions. Mechanical Embolus Removal in Cerebral Ischemia. H5570-23837-01 (Co Principal Investigator) 2004 - 2006 CoAxia Corporation (b) (4) direct/yr1 A Clinical Feasibility Study of Perfusion Augmentation in (b) (4) total Acute Ischemic Stroke Using the NeuroFlo Catheter H5570-2263-05 (National Principal Investigator) 2004 - 2008 Arterial Vascular Engineering Corporation/Medtronics (b) (4) direct/yr1 Corporation

95 of 193 Prepared: October 27, 2015

MAVERIC III: Use of Carotid Artery Stenting With Distal (b) (4) total Filter Protection H6201-25244-03 (Co Principal Investigator) 2005 - 2008 Cordis Neurovascular Corporation (b) (4) direct/yr1 Complex Trial: An post-market surveillance study of the (b) (4) total Cordis Trufill Detachable Coil System to treat Cerebral Artery Aneurysms (National Co-Principal Investigator) 2005 - 2008 Boston Scientific Corporation, Neurovascular Division (b) (4) direct/yr1 A Multi Center Trial To Evaluate Recurrent Subarachnoid (b) (4) total Hemorrhage In Ruptured Cerebral Aneurysms (CARAT) H5570-18907-05 (Co Principal Investigator) 2005 - 2007 Concentric Medical Corporation (b) (4) direct/yr1 MERCI Phase II Trial: Mechanical Embolus Removal in (b) (4) total Cerebral Ischemia (Co-Principal Investigator) 2005 - 2007 Cordis Neurovascular Corporation (b) (4) direct/yr1 Aneurysm Registry of the Orbit Complex Coil In Cerebral (b) (4) total Aneurysms 10-02273 (Co-Principal Investigator) 2006 - 2012 Boston Scientific Neurovascular (b) (4) direct/yr1 Wing Span Stent for Treatment of Intracranial (b) (4) total Atherosclerosis H12091-29756-01 (National Principal Investigator) 2006 - 2008 Nuvelo Corporation (b) (4) direct/yr1 CARNEROS I: Use of Alfimiprase in Acute Ischemic (b) (4) total Stroke (National Principal Investigator) (National Principal Investigator) 2006 - 2009 Actelion Pharmaceutical Corporation, Switzerland (b) (4) direct/yr1 CONSCIOUS I: Trial Evaluation of A New Vasodilatory (b) (4) total Drug For Prevention of Arterial Vasospasm from Subarachnoid Hemorrhage H6201-31117-01 (Co-Principal Investigator) 2007 - 2008 Cordis Endovascular, A Johnson and Johnson Company (b) (4) direct/yr1 SAPPHIRE: Senting and Angioplasty with Protection in (b) (4) total Patients at High-Risk for Endarterctomy. Carotid Stent Registry Study. H5570-29100-03 (Principal Investigato) 2008 - 2012 Guidant Corporation (b) (4) direct/yr1 CAPTURE 2: Post Approval study of the Guidant Acculink (b) (4) total Stent systems and Accunet Embolic Protection System

96 of 193 Prepared: October 27, 2015

10-02273 (Principal Investigator) 2010 - 2012 Abbott Pharmaceuticals (b) (4) direct/yr1 CHOICE: Carotid Stenting for High Surgical-Risk Patients: (b) (4) total Evaluating Outcomes Through the Collection of Clinical Evidence

PEER REVIEWED PUBLICATIONS

1. Hyman AL, Higashida RT, Spannhake EW, Kadowitz PF: Pulmonary vasoconstrictor responses to graded decreases in precapillary blood PO2 in intact chest cat. Journal of Applied Physiology 51(4):1009-1016, 1981.

2. King W, Higashida RT: The non-filled bladder: Techniques and applications in assessment of the early second trimester pregnancy. Radio graphics 4(5): 977-987, 1984.

3. Cochran ST, Higashida RT, Hulbert E, Winter J, Iwamoto K, Norman A: Development of rabbit brain tumor model for radiologic research. Investigative Radiology 20:928-932, 1985.

4. Tsai FY, Matovich V, Hieshima GB, Yoon JW, Shah D, Mehringer CV, Tiu G, Higashida RT, Pribram HF: Percutaneous transluminal angioplasty of the carotid artery. American Journal of Neuroradiology 7:349-358, 1986.

5. Hieshima GB, Higashida RT, Halbach VV, Cahan L, Goto K: Intravascular balloon embolization of a carotid-ophthalmic artery aneurysm with preservation of the parent vessel. American Journal of Neuroradiology 7(5):916-918, 1986.

6. Hieshima GB, Higashida RT, Wapenski J, Halbach V, Cahan L, Bentson J: Balloon embolization of a large distal basilar artery aneurysm. Journal of Neurosurgery 65 (3): 413-416, 1986.

7. Higashida RT, Hieshima GB, Halbach VV, Bentson JR, Goto K: Closure of carotid cavernous sinus fistulae by external compression of the carotid artery and jugular vein. Acta Radiologica 369:580-583, 1986.

8. Goto K, Hieshima GB, Higashida RT, Halbach VV, Bentson JR, Mehringer CM, Pribram HF: Treatment of direct carotid cavernous sinus fistulae: Various therapeutic approaches and results in 148 cases. Acta Radiologica 369:576-579, 1986.

9. Higashida RT, Hieshima GB, Halbach V, Goto K: Cervical carotid artery aneurysms and : Treatment by balloon embolization therapy. Acta Radiologica 369:591-593, 1986.

10. Higashida RT, Hieshima GB, Tsai FY, Bentson JR, Halbach VV: Percutaneous transluminal angioplasty of the subclavian and vertebral arteries. Acta Radiologica 369:124-126, 1986.

11. Tsai FY, Matovich VB, Hieshima GB, Higashida RT, Shah DG, Ashray, Pribram HF: Practical aspects of percutaneous transluminal angioplasty of the carotid artery. Acta Radiologica 369:127-139, 1986.

97 of 193 Prepared: October 27, 2015

12. Higashida RT, Hieshima GB, Halbach VV, Goto K, Dormandy B, Bell J, Cahan L, Bentson JR: Intravascular detachable balloon embolization of intracranial aneurysms: Indications and techniques. Acta Radiologica. 369:594-596, 1986.

13. Hieshima GB, Higashida RT, Wapenski JA, Halbach VV, Bentson JR: Intravascular balloon embolization of a large mid-basilar artery aneurysm. Journal of Neurosurgery 66:124-127, 1987.

14. Iwamoto K, Cochran ST, Winter J, Holburt E, Higashida RT, Norman A: Radiation dose enhancement therapy with iodine in rabbit VX-2 brain tumors. and 8(2):161-170, 1987.

15. Numaguchi Y, Higashida RT, Abernathy JM, Pisarello JC: Balloon embolization in a carotid-cavernous fistula in fibromuscular dysplasia. American Journal of Neuroradiology 8:380- 382, 1987.

16. Cahan LD, Higashida RT, Halbach VV, Hieshima GB: Variants of radiculomeningeal vascular malformations of the spine. Journal of Neurosurgery. Volume 66:333-337, 1987.

17. Halbach VV, Higashida RT, Hieshima GB, Reicher M, Norman D, Newton TH: Dural fistulas involving the cavernous sinus: Results of treatment in 30 patients. Radiology 163:437- 442, 1987.

18. Halbach VV, Higashida RT, Hieshima GB, Goto K, Norman D, Newton TH: Dural fistulas involving the transverse and sigmoid sinuses: Results of treatment in 28 patients. Radiology 163:443-447, 1987.

19. Higashida RT, Hieshima GB, Mehringer CM, Halbach VV: Giant cavernous aneurysm associated with trigeminal artery. Treatment by detachable balloon. American Journal of Neuroradiology 8(5):757-758, 1987.

20. Higashida RT, Hieshima GB, Halbach VV, Bentson JR, Tsai FY: Transluminal angioplasty of the vertebral and basilar artery. American Journal of Neuroradiology 8(5):745-750, 1987.

21. Brodsky MC, Hoyt WF, Higashida RT, Hieshima GB, Halbach VV: Bonnet-Dechaume- Blanc Syndrome with large facial angioma. Archives of Ophthalmology, 1987, 105: 854-855, 1987.

22. Halbach VV, Hieshima GB, Higashida RT, Reicher M, Norman D, Newton TH: Carotid cavernous fistulae: Indications for urgent treatment. American Journal of Neuroradiology 8:627- 633, 1987; and AJR 149:587-593, 1987.

23. Brodsky MC, Hoyt WF, Halbach VV, Hieshima GB, Higashida RT, Barbaro NM: Recovery from total monocular blindness after balloon embolization of carotid cavernous fistula. American Journal of Ophthalmology 104(1):86-87, 1987.

24. Hieshima GB, Reicher MA, Higashida RT, Halbach VV, Cahan LD, Martin NA, Frazee JG, Rand RW, Bentson JR: Intraoperative digital subtraction neuroangiography: A diagnostic and therapeutic tool. American Journal of Neuroradiology 8(5):759-768, 1987.

25. Halbach VV, Higashida RT, Hieshima GB, Norman D: Normal perfusion pressure breakthrough occurring during treatment of carotid and vertebral fistulas. American Journal of Neuroradiology 8(5):751-756, 1987.

98 of 193 Prepared: October 27, 2015

26. Halbach VV, Higashida RT, Hieshima GB: Treatment of vertebral arteriovenous fistulas. American Journal of Neuroradiology 8:1121-1128, 1987 and American Journal of Roentgenology 150:405-412, 1988.

27. Halbach VV, Higashida RT, Hieshima GB: Treatment of intracranial aneurysms by balloon embolization therapy. Seminars in Interventional Radiology 4(4):261-268, 1987.

28. Halbach VV, Higashida RT, Hieshima GB, Cahan L, Rosenblum M: Treatment of dural arterial venous malformations involving the superior sagital sinus. American Journal of Neuroradiology. Volume 9, No. 2, 337-343, 1988.

29. Higashida RT, Halbach VV, Cahan L, Hieshima GB: Cavernous carotid artery aneurysm associated with Marfan's syndrome: Treatment by balloon embolization therapy. Neurosurgery 22(2):297-300, 1988.

30. Higashida RT, Halbach VV, Hieshima GB, Weinstein PR, Hoyt WF: Treatment of a giant carotid ophthalmic artery aneurysm by intravascular balloon embolization therapy. Surgical Neurology, Volume 30, Number 5, 386-392, 1988.

31. Halbach VV, Higashida RT, Yang P, Barnwell S, Wilson CB, Hieshima GB: PreOperative balloon occlusion of arteriovenous malformations. Journal of Neurosurgery 22(2):301-308, 1988.

32. Tsuruda JS, Halbach VV, Higashida RT, Mark A, Hieshima GB, Norman D: MR evaluation of large and giant aneurysms using cine low flip angle gradient-refocused imaging. American Journal of Neuroradiology 9:415-424, 1988; and American Journal of Roentgenology 151:153- 162, July 1988.

33. Yang PJ, Halbach VV, Higashida RT, Hieshima GB: Platinum wire: A new transvascular embolic agent. American Journal of Neuroradiology. Volume 9:547-550, 1988.

34. Edwards MSB, Hieshima G, Higashida RT, Halbach V: Management of Vein of Galen malformations in the neonate. International . Volume 3(2):184-188, 1988.

35. Halbach VV, Higashida RT, Yang PJ, Hardin CW, Hieshima GB: Transvenous embolization of direct carotid cavernous fistulas. American Journal of Neuroradiology 9: 741-747, July/August 1988.

36. Halbach VV, Higashida RT, Hieshima GB, Hardin CW: Arteriovenous fistula of the internal maxillary artery: Treatment with transarterial embolization. Radiology 168:443-445, 1988.

37. Goto K, Halbach VV, Hardin CW, Higashida RT, Hieshima GB: Permanent inflation of detachable balloons with a low viscosity hydrophilic polymerizing system. Radiology 169:787- 790, 1988.

38. Higashida RT, Helmer E, Halbach VV, Hieshima GB: Direct thrombolytic therapy for transverse sinus dural thrombosis. American Journal of Neuroradiology. Volume 10, Number 55: 4-6, September 1989.

39. Higashida RT, Halbach VV, Tsai FY, Norman D, Pribram HF, Mehringer CM, Hieshima GB: Interventional neurovascular treatment of traumatic carotid and vertebral artery lesions: Therapeutic results in 234 cases. American Journal of Roentgenology. Volume 153:577-582, September 1989.

99 of 193 Prepared: October 27, 2015

40. Halbach VV, Higashida RT, Hieshima GB, Hardin CW: Embolization of branches arising from the cavernous portion of the internal carotid artery. American Journal of Neuroradiology 10: 143-150, January/February 1989.

41. Halbach VV, Higashida RT, Hieshima GB, Hardin CW: Direct puncture of the proximally occluded internal carotid artery for treatment of carotid cavernous fistulas. American Journal of Neuroradiology 10: 151-154. January/February 1989.

42. Halbach VV, Higashida RT, Hieshima GB, Hardin CW, Pribram HF: Transvenous embolization of dural fistulas involving the cavernous sinus. American Journal of Neuroradiology. Volume 10: 377-383, March/April 1989.

43. Halbach VV, Higashida RT, Hieshima GB, Wilson CB, Hardin CW, Kwan E: Treatment of dural fistulas involving the deep cerebral venous system. American Journal of Neuroradiology. Volume 10: 393-399, March/April 1989.

44. Yang PJ, Higashida RT, Halbach VV, Hieshima GB, Wilson CB: Intravascular embolization of a cerebellar arteriovenous malformation for treatment of hemifacial spasm. American Journal of Neuroradiology. Volume 10: 403-405, March/April 1989.

45. Halbach VV, Higashida RT, Hieshima GB, Mehringer CM, Hardin CW: Transvenous embolization of dural fistulas involving the transverse and sigmoid sinuses. American Journal of Neuroradiology. Volume 10: 385-392, March/April 1989.

46. Kwan E, Hieshima GB, Higashida RT, Halbach VV, Wolpert SM: Interventional neuroradiology in Neuro-ophthalmology: Journal of Clinical Neuro-Ophthalmology. 9(2): 83-97, 1989.

47. Higashida RT, Halbach VV, Cahan LD, Hieshima GB, Konishi Y: Detachable balloon embolization therapy of posterior circulation intracranial aneurysms. Journal of Neurosurgery. Volume 74, Number 4: 512-519, October 1989.

48. Higashida RT, Halbach VV, Cahan LD, Brant-Zawadzki M, Barnwell S, Dowd C, Hieshima GB: Transluminal angioplasty for treatment of intracranial arterial vasospasm. Journal of Neurosurgery. Volume 71, Number 5:648-653. November 1989.

49. Halbach VV, Higashida RT, Hieshima GB: Transarterial occlusion of solitary intracerebral arteriovenous connections. American Journal of Neuroradiology. Volume 10, No. 4, 747-752, July/August 1989.

50. Yang P, Halbach VV, Higashida RT, Hieshima GB: Intravascular embolization of a congenital subclavian arterial venous fistula. American Journal of Neuroradiology. Volume 10, Number 55: 25-27, September 1989.

51. Barnwell SL, Halbach VV, Higashida RT, Hieshima GB, Wilson CB: Complex dural arteriovenous fistulas: Results of combined endovascular and neurosurgical treatment in 16 patients. Journal of Neurosurgery. Volume 71, Number 3: 352-358, September 1989.

52. Halbach VV, Higashida RT, Hieshima GB: Interventional Neuroradiology. American Journal of Roentgenology. Volume 153:467-476, September 1989.

100 of 193 Prepared: October 27, 2015

53. Barnwell SL, Higashida RT, Halbach VV, Dowd, CF, Hieshima GB: Transluminal angioplasty of intracerebral vessels for cerebral arterial spasm: Reversal of neurologic deficits after delayed treatment. Neurosurgery. Volume 25, Number 3: 424-429, September 1989.

54. Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB: Endovascular treatment of scalp arteriovenous fistulas associated with a large varix. Radiology: Volume 173: 533-539, November 1989.

55. Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL: and venous pressure monitoring in dural sinus meningiomas. American Journal of Neuroradiology. Volume 10: Number 6: 1209-1214. November/December 1989.

56. Hieshima GB, Higashida RT, Halbach VV: Intravascular treatment of aneurysms. Clinical Neurosurgery. Volume 36: 338-343, 1989.

57. Higashida RT, Halbach VV, Dormandy B, Bell J, Hieshima GB. New microballoon device for transluminal angioplasty of intracranial arterial vasospasm. American Journal of Neuroradiology. Volume 11, Number 2: 233-238, March/April 1990.

58. Higashida RT, Halbach VV, Dormandy B, Bell J, Hieshima: Endovascular treatment of intracranial aneurysms using a new silicone microballoon device: Technical considerations and Indications. Radiology. Volume 174:687-691, March 1990.

59. Halbach VV, Higashida RT, Dowd C, Barnwell SL, Hieshima GB: Aneurysms of the petrous portion of the internal carotid artery: Results of treatment with endovascular or surgical occlusion. American Journal of Neuroradiology. Volume 11, Number 2: 253-256, March/April 1990.

60. Halbach VV, Higashida RT, Hieshima GB, Wilson CB, Barnwell SL, Dowd CF: Dural arteriovenous fistulas supplied by ethmoidal arteries. Neurosurgery. Volume 26, Number 5, 816- 823, 1990.

61. Barnwell SL, Halbach VV, Dowd C, Higashida RT, Hieshima GB: Dural arteriovenous fistulas involving the Inferior Petrosal Sinus. American Journal of Neuroradiology. Volume 11, Number 3, 511-516, May 1990.

62. Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Edwards MSB, Hieshima GB: Transfemoral venous embolization of Vein of Galen malformations. American Journal of Neuroradiology. Volume 11, Number 4: 643-648. July/August 1990.

63. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB: Treatment of carotid cavernous fistulas associated with Ehlers-Danlos syndrome. Neurosurgery. Volume 26, Number 6. pp. 1021-1027. June 1990.

64. Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB: Endovascular coil embolization of unusual PICA aneurysms. Neurosurgery. Volume 27, Number 6: 954-961. December 1990.

65. Higashida RT, Halbach VV, Dowd C, Barnwell SL, Dormandy B, Bell J, Hieshima GB: Endovascular detachable balloon embolization therapy of cavernous carotid artery aneurysms: Results in 87 Cases. Journal of Neurosurgery. Volume 72, Number 6: 857-863. June 1990.

101 of 193 Prepared: October 27, 2015

66. Higashida RT, Halbach VV, Barnwell SL, Dowd C, Dormandy B, Bell J, Hieshima GB: Treatment of intracranial aneurysms with preservation of the parent vessel: Results of percutaneous balloon embolization in 84 patients. American Journal of Neuroradiology. Volume 11, Number 4: 633-640. July/August 1990.

67. Ciricillo SF, Edwards MSB, Schmidt KG, Hieshima GB, Silverman MD, Higashida RT, Halbach VV : Interventional neuroradiological management of Vein of Galen Malformations in the Neonate. Neurosurgery, Volume 27, Number 1, 22-28, 1990.

68. Barnwell SL, Ciricillo SF, Halbach VV, Edwards MS, Cogen P. Dowd CF, Higashida RT, Hieshima GB: Intracerebral arteriovenous fistulas associated with intraparenchymal varix in infants. Neurosurgery 26 (1): 122-125, 1990.

69. Ciricillo SF, Schmidt KG, Silverman NH, Hieshima GB, Higashida RT, Halbach VV, Edwards M: Serial ultrasonographic evaluation of neonatal vein of Galen malformations to assess the efficacy of interventional neuroradiologic procedures. Neurosurgery. Volume 27, Number 4, pages 544-548, 1990.

70. Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: Interventional neurovascular treatment of a giant intracranial aneurysm using platinum micro coils. Surgical Neurology. Volume 35, Number 1: 64-68, January 1991.

71. Wilson CB, Hieshima GB, Higashida RT, Halbach VV, Dowd CF, Barnwell SL: Interventional radiological adjuncts in cerebrovascular surgery. Clinical Neurosurgery. Volume 37: 332-352. 1991.

72. Barnwell SL, Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Direct endovascular thrombolytic therapy for dural sinus thrombosis. Neurosurgery. Volume 28. Number 1: 135-142. February 1991.

73. Higashida RT, Hieshima GB, Halbach VV: Advances in the treatment of complex cerebrovascular disorders by interventional neurovascular techniques. Circulation. Volume 83, Number 2: I-196-206. February 1991.

74. Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Dormandy B, Bell J, Hieshima GB: Treatment of intracranial arterial vasospasm by interventional neurovascular techniques. Neuroradiology. Volume 33: 421-423, 1991.

75. Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Wilson CB: A variant of arteriovenous fistulas within the wall of dural sinuses: Results of combined surgical and endovascular therapy. Journal of Neurosurgery. Volume 74, Number 2: 199-204. February 1991.

76. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB: Vascular perforations resulting from neurointerventional procedures. Neuroradiology. Volume 33: 198-200. 1991.

77. Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB: Anterior choroidal artery embolization in cerebral arteriovenous malformations. Neuroradiology. Volume 33: 548-549, 1991.

78. Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL: Petrous carotid aneurysms treated by endovascular techniques. Neuroradiology. Volume 33: 419-420. 1991.

102 of 193 Prepared: October 27, 2015

79. Higashida RT, Tsai F, Halbach VV, Hieshima GB, Dowd CF, Barnwell SL: Percutaneous transluminal angioplasty of the subclavian, vertebral, and basilar arteries: Technical considerations. Neuroradiology. Volume 33: 394-396, 1991.

80. Tsai FY, Higashida RT, Matovich V, Alfieri K, Kobayashi S: Seven years experience with percutaneous transluminal angioplasty for carotid stenosis. Neuroradiology. Volume 33: 397 - 398. 1991.

81. Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB: Occlusion of the anterior superior ophthalmic vein in carotid-cavernous fistulae acutely aggravating visual symptoms. Neuroradiology. Volume 33: 142-143. 1991.

82. Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Dormandy B, Bell J, Hieshima GB: Interventional neurovascular treatment of intracavernous aneurysms. Neuroradiology. Volume 33: 136-138, 1991.

83. Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB, Dormandy B, Bell J: Interventional therapy for intracranial aneurysms by direct balloon occlusion: Clinical protocol and therapeutic results. Neuroradiology. Volume 33: 139-141. 1991.

84. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB: Treatment of dural arteriovenous fistulas involving the transverse and sigmoid sinuses by transvenous embolization: Results in 20 patients. Neuroradiology. Volume 33:550-552, 1991.

85. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB: Management of vascular perforations that occur during neurointerventional procedures. American Journal of Neuroradiology. Volume 12. Number 2: 319-328. March 1991.

86. Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: Intracranial Aneurysms: Interventional neurovascular treatment with detachable balloons - Results in 215 cases. Radiology. Volume 178. Number 3: 663-670. March 1991.

87. Barnwell SL, Halbach VV, Dowd C, Higashida RT, Hieshima GB, Wilson CB: Multiple dural arteriovenous fistulas of the cranium and spine. American Journal of Neuroradiology. Volume 12. Number 2:441-445, June 1991.

88. Halbach VV, Higashida RT, Barnwell SL, Dowd CF, Hieshima GB. Transarterial platinum coil embolization of carotid cavernous fistulas. American Journal of Neuroradiology. Volume 12, Number 3: 429-434. June 1991.

89. Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB: Particulate embolization of the anterior choroidal artery in the treatment of cerebral arteriovenous malformations. American Journal of Neuroradiology. Volume 12, Number 6. Pages 1055-1062. November/December 1991.

90. Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB: Intravascular balloon dilatation for intracranial arterial vasospasm: Patient selection, technique, and clinical results. Neurosurgical Review. Volume 15, Number 2. Pages 89-95, 1992.

91. Tsai FY, Higashida RT, Matovich V, Alfieri K: Acute thrombolysis of the intracranial dural sinus- Direct thrombolytic treatment. American Journal of Neuroradiology. Volume 13, Number 4: 1137-1142, July/August 1992.

103 of 193 Prepared: October 27, 2015

92. Halbach VV, Higashida RT, Dowd CF, Fraser KW, Smith TP, Teitelbaum GP, Wilson CW, Hieshima GB. Endovascular treatment of vertebral artery dissections and pseudoaneurysms. Journal of Neurosurgery. Volume 79, Number 2, 183-191, 1992.

93. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB: Transluminal angioplasty for atherosclerotic disease of the vertebral and basilar arteries. Journal of Neurosurgery. Volume 78:193-198, 1993.

94. Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB: Endovascular treatment of giant anterior circulation intracranial aneurysms. Journal of Surgery for Cerebral Stroke. Volume 21:113-117, 1993.

95. Smith TS, Graves VB, Halbach VV, Higashida RT, Fraser K, Dowd CF, Hieshima GB. Microcatheter retrieval device for intravascular foreign body removal.. American Journal of Neuroradiology. Volume 14, Number 4, pp. 809-811. 1993.

96. Halbach VV, Higashida RT, Dowd CF, Fraser KW, Smith TP, Edwards MS, Barnwell Sl, Teitelbaum GP, Hieshima GB: Treatment of giant intradural (perimedullary) arteriovenous fistulas. Neurosurgery. Volume 33, Number 6; December 1993.

97. Smith TP, Koci T, Mehringer CM, Tsai FY, Fraser KW, Dowd CF, Higashida RT, Halbach VV, Hieshima GB: Transarterial embolization of vertebral hemangiomas. Journal of Vascular and Interventional Radiology. Volume 4, Number 5, pp: 681-686, 1993.

98. Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Teitelbaum G, Hieshima GB: Interventional neurovascular treatment for giant aneurysms of the posterior circulation. Journal of Surgery for Cerebral Stroke. Volume 21, Number 5, 401-406, 1993.

99. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. Cerebral Percutaneous Transluminal Angioplasty. Journal of Heart Disease and Stroke. Volume 2, Number 6, pages 497-502. November/December 1993.

100. Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB: Endovascular management of acute carotid artery dissections. Journal of Surgery for Cerebral Stroke. Volume 21, Number 5, 407-412, 1993.

101. Teitelbaum GP, Halbach VV, Fraser KW, Larsen DW, McDougall CG, Higashida RT, Dowd CF, Hieshima GB. Direct puncture coil embolization of maxillofacial high-flow vascular malformation. Laryngoscope 104:1397-1400, 1994.

102. Fraser KW, Halbach VV, Teitelbaum GB, Smith TP, Higashida RT, Dowd CF, Wilson CB, Hieshima GB: Endovascular platinum coil embolization of incompletely surgically clipped cerebral aneurysms. Surgical Neurology. Volume 41; 4-8. 1994.

103. Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Fraser KW, Smith TP, Teitelbaum GP, Hieshima GB: The effectiveness of endosaccular aneurysm occlusion in alleviating the neurological deficits produced by mass effect. Journal of Neurosurgery: Volume 80, Number 4: 659-666. April 1994.

104. Terada T, Higashida RT, Halbach VV, Dowd CF, Tsuura M, Komai N, Wilson CB, Hieshima GB: Development of acquired arteriovenous fistulas in rats due to venous hypertension. Journal of Neurosurgery. Volume 80, Number 5, pp. 884-889. 1994.

104 of 193 Prepared: October 27, 2015

105. Teitelbaum GP, Higashida RT, Halbach VV, Larsen DW, McDougall CG, Dowd CF, Hieshima GB: Flow directed use of electrolytically detachable platinum embolization coils. Journal of Vascular and Interventional Radiology. Volume 5:453-456. 1994.

106. Smith TS, Higashida RT, Barnwell SL, Halbach VV, Dowd CF, Fraser K, Hieshima GB. Treatment of dural sinus thrombosis by urokinase infusion. American Journal of Neuroradiology. Volume 14:801-808. 1994.

107. Weiss JP, McLean GK, Modic MT, Tees CR, Higashida RT. Double-Blind study of a new nonionic for digital subtraction arteriography. Investigative Radiology. Volume 29; Supp 1; S84-S92; May 1994.

108. del Zoppo GJ, Higashida RT, Furlan AJ: The case for a Phase III trial of cerebral intra- arterial fibrinolysis. American Journal of Neuroradiology. Volume 15, Number 7. Pages 1217- 1222. 1994.

109. Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB: Thrombolytic therapy in acute stroke. Journal of Endovascular Surgery. Volume 1: 4-15. 1994.

110. Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB: Interventional neurovascular techniques for cerebral revascularization in the treatment of stroke. American Journal of Roentgenology. Volume 163, No. 4:793-800. 1994.

111. Yuh WT, Maeda M, Wang A, Crosby DL, Tien RD, Higashida RT, Tsai FY: Fibrinolytic Treatment of Acute Stroke: Are we treating reversible cerebral ischemia. American Journal of Neuroradiology. Volume 16:1994-2000. 1995.

112. Teitelbaum GP, Dowd CF, Larsen DW, McDougall CG, Halbach VV, Higashida RT, Hieshima GB. Endovascular management of biopsy-related posterior inferior cerebellar artery . Surgical Neurology 43:357-359, 1995.

113. Higashida RT, Tsai FY, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB: Interventional neurovascular techniques in the treatment of stroke: State of the Art Therapy. Journal of Internal Medicine. Volume 237:105-115, 1995.

114. Larsen DW, Halbach VV, Teitelbaum GP, McDougall CG, Higashida RT, Dowd CF, Hieshima GB: Spinal dural arteriovenous fistulas supplied by branches of the internal iliac arteries. Surgical Neurology. Volume 43:35-41;1995.

115. Smith TP, Halbach VV, Fraser KW, Teitelbaum GP, Dowd CF, Higashida RT: Percutaneous transluminal angioplasty of subclavian stenosis from neurofibromatosis. American Journal of Neuroradiology. Volume 16, No. 4: 872-874. April 1995.

116. Teitelbaum GP, Halbach VV, Larsen DW, McDougall CG, Dowd C, Higashida RT, Hieshima GB: Treatment of massive posterior epistaxis by detachable coil embolization of a cavernous internal carotid artery aneurysm. Neuroradiology 37: 334-336, 1995.

117. McDougall CG, Halbach VV, Dowd CF, Higashida RT, Larsen DW, Hieshima GB: Endovascular treatment of basilar tip aneurysms using electrolytically detachable coils. Journal of Neurosurgery. Volume 84; 393-399, 1996.

105 of 193 Prepared: October 27, 2015

118. Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Endovascular surgical approach to intracranial vascular diseases. Journal of Endovascular Surgery. Volume 3:146-157, 1996.

119. Terada T, Higashida RT, Halbach VV, Dowd CF, Nakai E, Yokote H, Itakura T, Hieshima GB. Transluminal angioplasty for arteriosclerotic disease of distal vertebral and basilar arteries. Journal of Neurology, Neurosurgery, and Psychiatry. Volume 60;377-381. 1996.

120. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB: Transluminal angioplasty, thrombolysis, and stenting for extracranial and intracranial cerebral vascular disease. Journal of Interventional Cardiology. Volume 9. Number 3. Pages 245-256. 1996.

121. Halbach VV, Higashida RT, Tsai FY, Dowd CF, Hieshima GB: Transluminal angioplasty of the extracranial carotid artery: Indications and technique- A Multicenter Interventional Neuroradiologists Perspective. Journal of Interventional Cardiology. . Volume 9. Number 3. Pages 233-244. 1996.

122. Terada T, Tsuura M, Komai N, Higashida RT, Halbach VV, Dowd CF, Wilson CB, Hieshima GB: The role of angiogenic factor bFGF in the development of dural AVFs. Acta Neurochirugia: 138:877-883, 1996.

123. Konishi Y, Halbach VV, Higashida RT, Dowd CF, Larsen DW, McDougall CG, Derugin N, Hieshima GB: Evaluation of acute thrombosis following microcoil aneurysm treatment in swine. Advances in Interventional Neuroradiology and Intravascular Neurosurgery. 1:45-50, 1996.

124. Balousek PA, Knowles HJ, Higashida RT, del Zoppo GJ: New interventions in cerebrovascular disease: The role of thrombolytic therapy and balloon angioplasty. Current Opinion in Cardiology: 11: 550-557, 1996.

125. McDougall CG, Halbach VV, Dowd CF, Higashida RT, Larsen DW, Hieshima GB: Dural arteriovenous fistulas of the marginal sinus. American Journal of Neuroradiology. 18:1565-1572, 1997.

126. Balousek PA, Smith WS, Gress DR, Halbach VV, Dowd CF, Urwin RW, Lempert T, Higashida RT: Angioplasty and stenting for carotid occlusive disease: Current status and recommendations. Journal of Neurovascular Disease. Volume 2, No. 2. Pages 52-58. 1997.

127. Pessin MS, Adams HP, Adams R, Fisher M, Furlan AJ, Hacke W, Haley EC, Hazinski MF, Higashida RT, Koroshetz W, Marler JR, Ornato JP: New and Emerging Treatments for Acute Ischemic Stroke. Acute Interventions Panel. American Heart Association. Stroke, Volume 28, Pages 1518-1521, 1997.

128. Halbach VV, Higashida RT, Dowd CF, Urwin RW, Balousek PA, Hieshima GB. Cavernous internal carotid artery aneurysms treated with electrolytically detachable coils. Journal of Neuro- Ophthalmology. Volume 17, Number 4; Pages 231-239, 1997.

129. Higashida RT, Smith W, Gress D, Urwin R, Dowd CF, Balousek P, Halbach VV: Intravascular stenting and endovascular coiling for a ruptured fusiform aneurysm of the basilar artery: Case report and review of the literature. Journal of Neurosurgery. Volume 87, Number 6, pages 944-949, 1997.

106 of 193 Prepared: October 27, 2015

130. del Zoppo GJ, Higashida RT, Furlan AJ, Pessin M, Rowley HA, Gent M, and the Proact Investigators. PROACT: A Phase II randomized trial of recombinant Pro-Urokinase by direct arterial delivery in acute middle cerebral artery stroke. Stroke. Volume 29. Pages 4-11, 1998.

131. Lempert TE, Halbach VV, Higashida RT, Dowd CF, Urwin RW, Balousek PA, Hieshima GB. Endovascular treatment of pseudoaneurysms with electrolytically detachable coils. American Journal of Neuroradiology. Volume 19; Number 5; Pages 907-911, May 1998.

132. Terada T, Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The effect of estrogen on the development of arteriovenous fistulae induced by venous hypertension in rats. Acta Neurochirugica 140: 82-86, 1998.

133. Halbach VV, Dowd CF, Higashida RT, Balousek PA, Urwin RW. Preliminary experience with a new embolic device: An electrolytically detachable fibered coil. American Journal of Neuroradiology. Volume 19, Number 4, Pages 773-777. April 1998.

134. Wholey MH, Wholey M, Bergeron P, Diethrich ED, Henry M, Laborde JC, Mathias K, Myla S, Roubin GS, Shawl F, Theron JG, Yadav JS, Dorros G, Guimaraens J, Higashida RT, Kumar V, Leon M, Lim M, Londero H, Mesa J, Ramee S, Rodriguez A, Rosenfield K, Teitelbaum G, Vozzi C. Current global status of carotid artery stent placement. Catheterization and Cardiovascular Diagnosis 44:1-6, 1998.

135. Halbach VV, Dowd CF, Higashida RT, Balousek P, Ciricillo S, Edwards MS. Endovascular treatment of mural type vein of Galen malformations. Journal of Neurosurgery. Volume 89; Pages 74-80, 1998.

136. Phatouros CC, Higashida RT: Diagnostic cerebral angiography. Carotid and Neurovascular Intervention. Volume 1, Number 1. Pages 10-20. 1998.

137. McDougall CG, Halbach VV, Dowd CF, Higashida RT, Larsen DW, Hieshima GB: Causes and management of aneurysmal hemorrhage occurring during embolization of Guglielmi detachable coils. Journal of Neurosurgery. Volume 89, Pages 87-92, 1998.

138. Lefkowitz, Teitelbaum G, Giannotta S, Higashida RT, Halbach VV, Dowd CF: The embolization of neurosurgical lesions involving the ophthalmic artery. Neurosurgery. Volume 43, Number 6; Pages 1298-1303. 1998.

139. Azakie A, McElhinney DB, Higashida RT, Messina LM, Stoney RJ: Innominate Artery Reconstruction: Over three decades of experience. Annals of Surgery. Volume 228; Pages 402- 410. 1998.

140. Malek AM, Higashida RT, Balousek PA, Phatouros CC, Smith WS, Dowd CF, Halbach VV: Endovascular recanalization with balloon angioplasty and stenting of an occluded occipital sinus for treatment of intracranial venous hypertension. Neurosurgery, Volume 44, Number 4, Pages 896-901. 1999.

141. Phatouros CC, Malek AM, Higashida RT, Smith WS, Mully TW, DeArmond SJ, Dowd CF, Halbach VV. Endovascular stenting of an acutely thrombosed basilar artery. Case Report and Review of the Literature. Neurosurgery. Volume 44; Number 3, Pages 667-673. 1999.

107 of 193 Prepared: October 27, 2015

142. Malek AM, Halbach VV, Phatouros CC, Higashida RT, Dowd CF, Wachhorst S, Lawton M,: Spinal dural arteriovenous fistula with an associated feeding artery aneurysm: Case Report. Neurosurgery. Volume 44, Number 4, Pages 877-880. 1999.

143. Lempert TE, Halbach VV, Malek AM, Phatouros CC, Dowd CF, Higashida RT: Rescue Treatment of Acute Parent Vessel Thrombosis with Glycoprotein IIb/IIIa Inhibitor during GDC coil embolization. Stroke: 30(3), 693-695, 1999.

144. Malek AM, Higashida RT, Phatouros CC, Dowd CF, Halbach VV. Treatment of an intracranial aneurysm using a new three-dimensional-shape Guglielmi detachable coil: Technical case report. Neurosurgery, Volume 44, Number 5, Pages 1142-1145; May 1999.

145. Dowd CF, Phatouros CC, Malek AM, Lempert TE, Meyers PM, Halbach VV, Higashida RT: Embolization of non-ruptured aneurysms. Journal of Interventional Neuroradiology. Suppl. 1; 93-96; 1999.

146. Malek AM, Higashida RT, Phatouros CC, Halbach VV: A Strangled Wife. Lancet. Volume 353, Page 1324, April 17, 1999.

147. Phatouros CC, Higashida RT, Malek AM, Meyers PM, Dowd CF, Halbach VV: Clinical use of stents for Carotid Artery Disease. Neurologia Medico-Chirugica. Volume 39, Issue 12, pages 809-827, 1999.

148. Malek AM, Higashida RT, Halbach VV, Phatouros CC, Meyers PM, Dowd CF: Tandem stent deployment for the treatment of a flow limiting basilar artery dissection induced by placement of an intracranial vertebral stent. Volume 45, Number 4, pages 919-924. Neurosurgery. 1999.

149. Phatouros CC, Halbach VV, Malek AM, Meyers PM, Dowd CF, Higashida RT: Intraventricular Contrast Leakage during ethanol embolization of an arteriovenous malformation. American Journal of Neuroradiology. Volume 20; Pages 1329-1332. August 1999.

150. Malek AM, Halbach VV, Phatouros CC, Meyers PM, Holmes SM, Dowd CF, Higashida RT: Beating Aneurysm Sign: Angiographic evidence of ruptured aneurysm tamponade by . Journal of Neurosurgery. Volume 91, Page 517, September 1999.

151. Miyawaki L, Dowd CF, Wara W, Albright N, Goldsmith B, Gutin P, Halbach VV, Hieshima GB, Higashida RT, Ling C, Lulu B, Pitts L, Schell M, Smith V, Weaver K, Wilson C, Larson D: Five Year results of LINAC Radio surgery for Arteriovenous Malformations: Outcome for large AVM's. International Journal of Radiation Oncology, Biology, and Physics. Volume 44, Number 5; pages 1089-1106. 1999.

152. Malek AM, Higashida RT, Phatouros CC, Lempert TE, Meyers PM, Gress Dr, Dowd CF, Halbach VV: Treatment of posterior circulation ischemia with percutaneous balloon angioplasty and stent placement. Stroke. Volume 30, Pages 2073-2085. 1999.

153. Phatouros CC, Malek AM, Higashida RT, Khosla D, Smith W, Dowd CF, Halbach VV: Embolization of the meningohypophyseal trunk causing diabetes insipidus. Case report and review of the literature. American Journal of Neuroradiology. Volume 20, Number 6, Pages 1115- 1118. July 1999.

108 of 193 Prepared: October 27, 2015

154. Furlan A, Higashida RT, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F, Proact Investigators: Intra-arterial Prourokinase for Acute Ischemic Stroke: The Proact II Study: A Randomized Controlled Trial. Journal of the American Medical Association, December 1, 1999. Volume 282, Number 21, Pages 2003-2011.

155. Malek AM, Halbach VV, Phatouros CC, Meyers PM, Dowd CF, Higashida RT: Endovascular treatment of a ruptured intracranial dissecting vertebral aneurysm in a kick boxer. Journal of Trauma. Volume 48, Number 1, Pages 1-3, 1999.

156. Phatouros CC, Malek AD, Dowd CF, Higashida RT: Simultaneous subarachnoid hemorrhage and carotid cavernous fistula following iatraogenic aneurysm rupture during a balloon assist GDC embolization. American Journal of Neuroradiology. Volume 20, Number 6, Pages 1100-1103. July 1999.

157. Tsai FY, Koenigsberg RA, Roth T, Eckard D, Dhillon G, McCormick D, Higashida RT, Wang AM: PTA assisted stenting for extracranial vascular disease. Rivista di Neuroradiologia. Volume 12, Supplement 2, Page 80-85, March 1999.

158. Phatouros CC, Halbach VV, Dowd CF, Lempert TE, Malek AM, Meyers PM, Higashida RT: Acquired Pial Arteriovenous Fistula Following Cerebral Vein Thrombosis. Stroke; 30: 2487-2490. 1999.

159. Koenigsberg RA, Dave A, McCormick D, Roth T, Wilson A, Weiss J, Higashida RT, Faro SH, Grandinetti LM, Tsai FY: Complicated stent supported cerebrovascular angioplasty: Case Analysis and Review of the Literature. Surgical Neurology. 1999. Volume 53. Issue 5. Pages 465-474.

160. Malek AM, Higashida RT, Reilly LM, Smith WS, Kang SM, Gress DR, Meyers PM, Phatouros CC, Halbach VV, Dowd CF. Subclavian arteritis and pseudoaneurysm formation secondary to stent . Journal of Cardiovascular and Interventional Radiology. 2000.

161. Phatouros C, Higashida RT, Malek AM, Halbach VV, Dowd CF: Carotid Artery Stent Placement for Atherosclerotic Disease: Rationale, Technique, and Current Status. State of the Art Review. Radiology. Volume 217; Pages 26-41. October 2000.

162. Lempert TE, Malek AM, Halbach VV, Phatouros CC, Meyers PM, Dowd CF, Higashida RT: Endovascular treatment of ruptured posterior circulation cerebral aneurysms: Clinical and Angiographic outcomes. Stroke. Volume 31; Number 1. Pages 100-110. January 2000.

163. Malek AM, Higashida RT, Smith WS, Halbach VV, Dowd CF, Phatouros CC, Lempert TE, Meyers PM, Smith WS, Stony R: Patient presentation, angiographic features, and treatment of strangulation-induced dissection of the cervical internal carotid artery. Journal of Neurosurgery. Volume 92, 481-487, March 2000.

164. Phatouros CC, Higashida RT, Malek AM, Meyers PM, Lempert TE, Dowd CF, Halbach VV: Endovascular stenting for carotid artery stenosis: Preliminary experience using the Shape Memory-Alloy Recoverable-Technology Stent. American Journal of Neuroradiology. Volume 21;732-738; Number 4; April 2000.

165. Higashida RT, Hopkins LN, Berenstein A, Halbach VV, Kerber C, and the American Society of Interventional and Therapeutic Neuroradiology, Joint Section for Cerebrovascular Neurosurgery, Congress of Neurological Surgeons, American Association of Neurological

109 of 193 Prepared: October 27, 2015

Surgeons, American Society of Neuroradiology: Program Requirements for Residency/Fellowship Education in Neuroendovascular Surgery/Interventional Neuroradiology. American Journal of Neuroradiology. Volume 21, Pages 1153-1159. 2000.

166. American Society of Interventional and Therapeutic Neuroradiology, Joint Section for Cerebrovascular Neurosurgery, Congress of Neurological Surgeons, American Association of Neurological Surgeons, American Society of Neuroradiology, Higashida RT, Hopkins LN, Berenstein A, Halbach VV, Kerber C: Program Requirements for Residency/Fellowship Education in Neuroendovascular Surgery/Interventional Neuroradiology. Neurosurgery. Volume 46, Number 6, 1486-1497. 2000.

167. Malek AM, Higashida RT, Phatouros CC, Lempert TE, Meyers PM, Smith WS, Dowd CF, Halbach VV: Stent Angioplasty for Cervical Carotid Artery Stenosis in High-Risk Symptomatic NASCET-Ineligible Patients. Stroke. Volume 31: 3029-3033. 2000.

168. Dowd CF, Meyers PM, Malek, AM, Phatouros CC, Lempert TE, Lefler JE, Higashida RT, Halbach VV: Pre-Operative embolization and endovascular treatment of midline facial and skull base Lesions. Operative Techniques in Neurosurgery. Volume 3, Number 1, Pages 2-15. March 2000.

169. Meyers PM, Higashida RT, Phatouros CC, Malek AM, Lempert TE, Dowd CF, Halbach VV: Cerebral hyperperfusion syndrome after percutaneous transluminal stenting of the cervicocranial arteries. Neurosurgery. Volume 47, Number 2, 335-345; August 2000.

170. Malek AM, Halbach VV, Phatouros CC, Lempert TE, Meyers PM, Dowd CF, Higashida RT: Balloon-assist technique for endovascular coil embolization of geometrically difficult intracranial aneurysms. Neurosurgery. Volume 46, Number 6, Pages 1397-1407. June 2000.

171. Higashida RT: Evolution of a new multidisciplinary subspecialty: Interventional Neuroradiology/Neuroendovascular Surgery. American Journal of Neuroradiology. Volume 21, Pages 1151-1152. 2000.

172. Meyers PM, Halbach VV, Phatouros CC, Dowd CR, Malek AM, Lempert TE, Lefler JE, Higashida RT: Hemorrhagic Complications in Vein of Galen malformations. Annals of Neurology; Volume 47; Pages 748-755. 2000.

173. Meyers PM, Halbach VV, Malek AM, Phatouros CC, Dowd CF, Lawton MT, Higashida RT: Endovascular treatment of cerebral artery aneurysms during pregnancy. American Journal of Neuroradiology: Volume 21: Pages 1306-1311. August 2000.

174. Phatouros CC, Sasaki TYJ, Higashida RT, Malek AM, Meyers P, Dowd CF, Halbach VV. Stent-supported coil embolization: The treatment of fusiform and wide-neck aneurysms and pseudoaneurysms. Neurosurgery. Volume 47; Number 1; Pages 107-115. July 2000.

175. Johnston SC, Wilson CB, Halbach VV, Higashida RT, Dowd CF, McDermott MW, Applebury CB, Farley TL, Gress DR: Endovascular and Surgical Treatment of Unruptured Cerebral Aneurysms: Comparison of Risks. Annals of Neurology. Volume 48; Pages 11-19, 2000.

176. Malek AM, Higashida RT, Phatouros CC, Lempert TE, Meyers PM, Smith WS, Dowd CF, Halbach VV: Endovascular management of extracranial carotid artery dissection achieved using stent angioplasty. American Journal of Neuroradiology 21:1280-1292, August 2000.

110 of 193 Prepared: October 27, 2015

177. Wholey MH, Wholey M, Mathias K, Roubin GS, Diethrich EB, Henry M, Bailey S, Bergeron P, Dorros G, Eles G, Gaines P, Gomez CR, Gray B, Guimaraens J, Higashida R, Ho DSW, Katzen B, Kambara A, et al: Global Experience in Cervical Carotid Artery Stent Placement. Catheterization and Cardiovascular Interventions 50:160-167, 2000.

178. Phatouros CC, Lefler JE, Higashida RT, Meyers PM, Malek AM, Dowd CF, Halbach VV. Primary stenting for high-grade basilar artery stenosis. American Journal of Neuroradiology. Volume 21:1744-1749, October 2000.

179. Rapp JH, Pan XM, Sharp FR, Shah DM, Wille GA, Velez, PM, Troyer A, Higashida RT, Saloner D. Atheroemboli to the Brain: Size Threshold for causing Acute Neuronal Death. Journal of Vascular Surgery. 2000; 32: 68-76.

180. Emergency interventional stroke therapy: A Statement from the American Society of Interventional and Therapeutic Neuroradiology and Society of Cardiovascular and Interventional Radiology. (Higashida, RT, collaborator) Journal of Vascular and Interventional Radiology. 2001; Volume12: Number 2. Pages 143 and the American Journal of Neuroradiology. volume 22: 54; January 2001.

181. Intra-arterial Thrombolysis: Ready for Prime Time? (Higashida, RT, collaborator) Executive Committee of the American Society of Interventional and Therapeutic Neuroradiology. American Journal of Neuroradiology. Volume 22: 55-58; January 2001.

182. Higashida RT, Connors JJ: Should Interventional Radiologists by Involved in Acute Stroke Intervention?. Journal of Vascular and Interventional Radiology. Volume 12, Number 2, February 2001. Pages 145-146.

183. Meyers PM, Halbach VV, Dowd CF, Lempert TE, Lefler JE, Malek AM, Phatouros CC, Higashida RT: Endovascular treatment of a ruptured dual aperture cavernous aneurysm. Journal of Neuroimaging. 2001; 11: 71-75.

184. Reporting Terminology for Brain Arteriovenous Malformation: Clinical and Radiographic Features for use in Clinical Trials. (Higashida, RT, collaborator) Technology Assessment Committee, American Society of Interventional and Therapeutic Neuroradiology, Joint Section on Cerebrovascular Neurosurgery, and the Section of Stroke and the Section of Interventional Neurology of the American Academy of Neurology. Stroke 2001: 32: 1430-1442.

185. Singh V, Meyers PM, Halbach VV, Gress DR, Higashida RT, Smith WS: Dural arteriovenous fistula associated with prothrombin gene mutation. Journal of Neuroimaging. 2001;Volume 11: 319-321.

186. Dawson RC, Barr JD, Connors JJ, Dowd CF, Duckwiler G, Eckard DA, Hendrix LE, Higashida RT, Horton JA, Hurst RW, Jensen ME, Kerber CW, Marks MP, Mathis JM, Moser FG, Pile-Spellman J, Purdy PD, Russell EJ, Sanders WP, Tarr RW, Tomsick TA, Wallace RC, Wojak J: Standards of Practice: The American Society of Interventional and Therapeutic Neuroradiology. American Journal of Neuroradiology. Volume 22, Number 8. September 2001.

187. Chun JY, Smith W, Halbach VV, Higashida RT, Wilson CB, Lawton MT: Current Multimodality Management of Infectious Intracranial Aneurysms. Neurosurgery, Volume 48, Number 6, 1203-1214, 2001.

111 of 193 Prepared: October 27, 2015

188. Kase CS, Furlan AJ, Wechsler LR, Higashida RT, Rowley HA, Hart RG, Molinari GF, Frederick LS, Roberts HC, Gebel JM, Sila CA, Schulz GZ, Roberts RS, Gent M, and the Proact Investigators. Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke. The Proact II trial. Neurology 57: 1603-1610. 2001.

189. Gress DR, Smith WS, Dowd CF, Halbach VV, Finley RJ, Higashida RT: Angioplasty for Intracranial Symptomatic Vertebrobasilar Ischemia. Neurosurgery 2002. Volume 51, Number 1, Pages 23-29.

190. Halim AX, Singh V, Johnston C, Higashida RT, Dowd CF, Halbach VV, Lawton MT, Gress DR, McCulloch CE, Young WL, UCSF BAVM Study Project: Characteristics of Brain Arteriovenous Malformations with Coexisting Aneurysms: A Comparison of Two Referral Centers. Stroke. 2002; Volume 33. Pages 675-679.

191. Chun J, Berger MS, McDermott M, Lamborn K, Wilson CB, Higashida RT: Delayed surgical resection reduces intraoperative blood loss in embolized meningiomas. Neurosurgery. 2002. Volume 50, Number 6, Pages 1231-1238.

192. Singh V, Gress DR, Higashida RT, Dowd CF, Halbach VV, Johnston C: The learning curve for coil embolization of unruptured intracranial aneurysms. American Journal of Neuroradiology. Volume 23. Pages 768-771, May 2002.

193. n-Butyl Cyanoacrylate Embolization of Cerebral Arteriovenous Malformations: Results of a Prospective, Randomized, Multi-Center Trial. (Higashida RT, collaborator) The n-BCA Trial Investigators. American Journal of Neuroradiology. Volume 23. Pages 748-755. May 2002.

194. Roberts HC, Dillon WP, Furlan AJ, Wechsler LR, Rowley HA, Fischbein NJ, Higashida RT, Kase C, Schulz GA, Lu Y, Firszt CM, and the Proact Investigators: Computed Topographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to Middle Cerebral Artery Occlusion: Results from the Proact II Trial. Stroke. Volume 33; Pages 1557- 1567, 2002.

195. Meyers PM, Halbach VV, Dowd CF, Lempert TE, Malek AM, Phatouros CC, Lefler JE, Higashida RT: Dural carotid cavernous fistula: Definitive endovascular management and long- term follow up. American Journal of Ophthalmology. Volume 134; Pages 85-92; 2002.

196. Claiborne SC, Higashida RT, Barrow DL, Caplan LR, Dion JE, Hademenos G, Hopkins LN, Molyneux A, Rosenwasser RH, Vinuela F, Wilson CB: Recommendations for the Endovascular Treatment of Intracranial Aneurysms. A Statement for Healthcare Professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radiology. Stroke 2002: Volume 33. Pages 2536-2544.

197. Phatouros CC, Meyers PM, Higashida RT, Malek AM, Lempert TE, Dowd CF, Halbach VV, Morrish WF: Intracranial hemorrhage and cerebral hyperperfusion syndrome after extracranial carotid artery angioplasty and stent placement. American Journal of Neuroradiology 2002: 23: 503-504.

198. Wechsler LR, Roberts R, Furlan A, Higashida RT, Dillon W, Roberts H, Rowley H, Pettigrew LC, Callahan AS, Bruno A, Fayad P, Smith WS, Firszt CM, Schulz GA, and the Proact II Investigators: Factors influencing outcome and treatment effect in Proact II. Stroke 2003. Volume 34; 1224-1229.

112 of 193 Prepared: October 27, 2015

199. Adams HP, Adams RJ, Brott T, del Zoppo GJ, Furlan A, Goldstein LB, Grubb RL, Higashida RT, Kidwell C, Kwiatkowski TG, Marler JR, Hademenos GJ: Guidelines for the Early Management of Patients with Ischemic Stroke: A Scientific Statement from the Stroke Council of the American Stroke Association. Stroke. 2003; 34:1056-1083.

200. Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CA, Schulz G, Buchan AM. for the PROACT-II Investigators. Selection of Acute Ischaemic Stroke Patients for Intra-Arterial Thrombolysis with Prourokinase Using ASPECTS. Stroke 2003; 34: 246-247.

201. Derdeyn CP, Barr JD, Berenstein A, Connors JJ, Dion JE, Duckwiler GR, Higashida RT, Tomsick T: The International Subarachnoid Aneurysm Trial: A Position Statement from the Executive Committee of the American Society of Interventional and Therapeutic Neuroradiology. American Journal of Neuroradiology. 2003. Volume 24. Pages 1404-1408.

202. Hashimoto T, Wen G, Lawton MT, Boudreau NJ, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL, UCSF Brain AVM Study Group: Abnormal Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Brain Arteriovenous Malformations. Stroke 2003; 34:925-931.

203. Latchaw RE, Yonas H, Hunter GJ, Yuh WT, Ueda T, Sorensen AG, Sunshine JL, Biller J, Wechsler L, Higashida RT, Hademenos G: Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia. A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, from the Council on Cardiovascular Radiology of the American Heart Association. Stroke 2003, 34:1084-1104.

204. Ng PP, Halbach VV, Quinn R, Balousek P, Caragine LP, Dowd CF, Higashida RT, Wilson CB: Endovascular Treatment for Dural Arteriovenous Fistulae of the Superior Petrosal Sinus. Neurosurgery 2003. Volume 53, Pages 25-33; July 2003.

205. Dowd CF, Halbach VV, Higashida RT: Meningiomas: The Role of Pre-Operative Angiography and Embolization. Neurosurgical Focus. 2003.

206. Caragine LP, Halbach VV, Dowd CF, Ng PP, Higashida RT. Parallel venous channel as the recipient pouch in transverse/sigmoid sinus dural fistulae. Neurosurgery 2003. December 53(6):1261-1266; Discussion 1266-1267.

207. Ng P, Halbach VV, Caragine LP, Dowd CF, Higashida RT: Guglielmi Detachable Coil Extraction: Suction Generated by Pusher-Wire Withdrawal after Coil Detachment within an Intracranial Aneurysm. American Journal of Neuroradiology 2003: 24: 982-984.

208. Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D, for the Technology Assessment Committees of the American Society of Interventional and Therapeutic Neuroradiology and the Society of Interventional Radiology. Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke. Stroke, 2003: Volume 34. Pages 1923-1924. and Stroke 2003; 34:e109- e137. and the Journal of Vascular and Interventional Radiology 2003; 14:945-946.

209. Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D: Cerebral Ischemia and Infarction From Atheroemboli <100um in Size. Stroke. 2003; 34:1976-1980.

113 of 193 Prepared: October 27, 2015

210. Ng P, Higashida RT, Dowd CF, Halbach VV: Endovascular Strategies for the Treatment of Carotid Cavernous and Intracerebral Dural Arteriovenous Fistulae. Neurosurgical Focus. Volume 15, Number 4. October 2003.

211. Barr JD, Connors JJ, Sacks D, Wojak JC, Becker GJ, Cardella JF, Chopko B, Dion JE, Fox AJ, Higashida RT, Hurst RW, Lewis CA, Matalon TAS, Nesbit GM, Pollock JA, Russell EJ, Seidenwurm DJ, Wallace RC, for the ASITN and SIR Standards of Practice Committees. Quality Improvement Guidelines for the Performance of Cervical Carotid Angioplasty and Stent Placement. Journal of Vascular and Interventional Radiology 2003. Volume 14, Pages S321- S335. and the Journal of Vascular and Interventional Radiology 2003; 14:1079-1093. American Journal of Neuroradiology. Volume 24:2020-2034, 2003.

212. Jou LD, Quick CM, Young WL, Lawton ML, Higashida RT, Martin A, Saloner D: Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. American Journal of Neuroradiology. Volume 24, Pages 1804-1810. 2003.

213. Higashida RT: Endovascular angioplasty and stenting for intracranial atherosclerosis. Japan Journal of Stroke. Volume 25. 353-355; 2003.

214. Yu W, Binder D, Foster-Barber A, Malek R, Smith WS, Higashida RT: Endovascular embolectomy of acute basilar artery occlusion. Neurology. 61: 1421-1423. 2003.

215. Ng PP, Halbach VV, Balousek P, Quinn R, Caragine LP, Dowd CF, Higashida RT: Endovascular and surgical treatment for dural arteriovenous fistulae of the superior petrosal sinus. Rivista di Neuroradiologia. Volume 16, Pages 1291-1297, December 2003.

216. Schumacher HC, Khaw AV, Meyers PM, Gupta R, Higashida RT: Intracranial angioplasty and stent placement for cerebral atherosclerosis. Journal of Vascular and Interventional Radiology. Volume 15:S123-132. 2004.

217. IMS Study Investigators. (Higashida RT, collaborator). Combines intravenous and intra- arterial recanalization for acute ischemic stroke: The Interventional Management of Stroke Study. Stroke 2004, April 35(4):904-911. EPub 2004, March 11.

218. Ng PP, Higashida RT, Cullen SP, Malek R, Dowd CF, Halbach VV: Intra-Arterial Thrombolysis Trials in Acute Ischemic Stroke". Journal of Vascular and Interventional Radiology. Volume 15:S77-S85; 2004.

219. Khaw AV, Schumacher HC, Meyers PM, Gupta R, Higashida RT: Extracranial revascularization therapy: Angioplasty and Stenting. Current Treatment Options in Cardiovascular Medicine 2004; 6(3): 179-192.

220. Kim EJ, Halim AX, Dowd CF, Lawton MT, Singh V, Bennett J, Young WL, UCSF BAVM Study Project, et al (Higashida, RT, collaborator): The relationship of coexisting extranidal aneurysms to intracranial hemorrhage in patients harboring brain arteriovenous malformations. Neurosurgery. Volume 54: Pages 1349-1358. 2004.

221. Smith WS, Dowd CF, Johnston C, Ko KU, DeArmond SJ, Dillon WP, Setty D, Lawton MT, Young WL, Higashida RT, Halbach VV: Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 35:2518-2522; 2004.

114 of 193 Prepared: October 27, 2015

222. Schumacher HC, Khaw AV, Meyers PM, Gupta R, Higashida RT: Intracranial Revascularization Therapy: Angioplasty and Stenting. Current Treatment Options in Cardiovascular Medicine 2004; 6(3): 193-198.

223. Higashida RT, Meyers PM, Phatouros CC, Connors JJ, Barr JD, Sacks D, and the Technology Assessment Committees of the American Society of Interventional and Therapeutic Neuroradiology and the Society of Interventional Radiology: Reporting Standards for Carotid Artery Angioplasty and Stent Placement. Stroke 2004;35:1225-1226; and 3112-e133. Journal of Vascular and Interventional Radiology. 15:E1-E24; 2004; Journal of Vascular and Interventional Radiology 20:S349-S373; 2004.

224. Ko NU, Achrol AS, Chopra M, Saha M, Gupta D, Smith WS, Higashida RT, Young WL. Cerebral blood flow changes after endovascular treatment of cerebrovascular stenosis. American Journal of Neuroradiology. March 2005;26:538-542.

225. Martin A, Saloner D, Roberts T, Heidi R, Weber OM, Dillon W, Cullen S, Halbach VV, Dowd CF, Higashida RT: Carotid stent delivery in an XMR suite: Immediate assessment of the physiologic impact of extracranial revascularization". American Journal of Neuroradiology. March 2005; 26: 531-537.

226. Ko NU, Achrol AA, Martin AJ, Chopra M, Saloner DA, Higashida RT, Young WL: Magnetic resonance perfusion tracks 133 Xenon Cerebral Blood flow changes after carotid stenting. Stroke, 36:676-678; March 2005.

227. Yu W, Smith WS, Singh V, Ko NU, Cullen SP, Dowd CF, Halbach VV, Higashida RT: Long- term outcome of endovascular stenting for symptomatic basilar artery stenosis. Neurology 64:1055-1057; 2005.

228. Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin P, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP, for the MERCI Trial Investigators. Safety and efficacy of mechanical embolectomy in acute ischemic stroke. Results of the MERCI Trial. Stroke. 2005;36:1432-1440.

229. Fullerton HJ, Achrol AS, Johnston SC, McCulloch CE, Higashida RT, Lawton ML, Sidney S, Young WL, & the UCSF BAVM Study Project: Long-Term Hemorrhage Risk in Children Versus Adults With Brain Arteriovenous Malformations. Stroke 2005;36:2099-2104.

230. Meyers SP, Higashida RT: Endovascular treatment of extracranial carotid artery stenosis: Update on carotid angioplasty and stenting. Neuroimaging of North America: 2005 May;15(2):383-395.

231. Liang-Der J, Wong G, Dispensa B, Lawton MT, Higashida RT, Young WL, Saloner D: Correlation between luminal geometry changes and hemodynamics in fusiform intracranial aneurysms. American Journal of Neuroradiology. October 2005;26(9):2357-2363.

232. Lutsep H, Rymer for the MERCI™ Investigators Recanalization Rates and Outcomes in Patients with Posterior Circulation Stroke in the MERCI Trial. (Higashida, RT, collaborator) Stroke 2005;36:203-204.

233. Higashida RT, Halbach VV, Dowd CF, Juravsky L, Meagher S: Initial clinical experience with a New Self-Expanding Nitinol Stent for the Treatment of Intracranial Cerebral Aneurysms: The Cordis Enterprise Stent. American Journal of Neuroradiology 26:1751-1756, August 2005.

115 of 193 Prepared: October 27, 2015

234. Higashida RT: Recent advances in the interventional treatment of acute ischemic stroke. Cerebrovascular Diseases: 2005;20(suppl 2):140-147.

235. Higashida RT, Meyers PM, Connors JJ, Sacks D, Strother CM, Barr JD, Wojak JC, Duckwiler GR: Intracranial Angioplasty & Stenting for Cerebral Atherosclerosis: A Position Statement of the Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. American Journal of Neuroradiology 2005: 26(9);2323-2327. Journal of Vascular & Interventional Radiology 2005. Journal of Vascular and Interventional Radiology 20:S312-S316; 2009.

236. Meyers PM, Schumacher C, Higashida RT, Leary MC, Caplan LR: Use of stents to treat extracranial cerebral vascular disease. Annual Review of Medicine. 2006. 57:437-454.

237. Wintermark M, Ko NU, Smith WS, Liu S, Higashida RT, Dillon W: Vasospasm after subarachnoid hemorrhage: Utility of Perfusion-CT and CT-Angiography on Diagnosis and Management. AJNR (27)26-34, 2006.

238. Safety of mechanical thrombectomy and intravenous t-PA in acute ischemic stroke. Results of the Multi MERCI Trial, Part I. Multi MERCI Writing Committee for the Multi MERCI Investigators (Higashida RT, collaborator): American Journal of Neuroradiology. Volume 27;1177-1182. 2006.

239. Higashida RT, Meyers PM: Intracranial angioplasty and stenting for cerebral atherosclerosis: New treatments for stroke are needed. Neuroradiology. June 2006. Volume 48:367-372.

240. The Cerebral Aneurysm Re-rupture After Treatment (CARAT) Investigators (Higashida RT, collaborator): Rates of delayed re-bleeding from intracranial aneurysms are low after surgical and endovascular treatment. Stroke 2006;37:1437-1442.

241. Higashida RT, Cognard C, Bracard S: Initial clinical experience with a new complex- shaped detachable platinum coil system for the treatment of intracranial cerebral aneurysms: The Cordis Trufill DCS Detachable Coil System. Interventional Neuroradiology. Volume 12, Number 2, Page 123-130. 2006.

242. Hill MD, Kent D, Hinchey JA, Higashida RT, Dillon W, Wechsler L, Rowley H, Fischbein N, Gent M, Furlan A, Schulz GA: Sex-Based differences in the effect of intra-arterial treatment of stroke: Analysis of the PROACT-2 Study. Stroke 37; 2322-2325; 2006.

243. Caragine LP, Halbach VV, Dowd CF, Higashida RT. Intra-orbital arteriovenous fistulae of the ophthalmic veins treated by transvenous endovascular occlusion. Neurosurgery. 2006. February 58(1 Suppl):ONS-E170; Discussion ONS-E170.

244. Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden P, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EFM. Guidelines for the Early Management of Adults with Ischemic Stroke: A Guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes In Research Interdisciplinary Working Groups. Stroke 2007; 38:1655-1711.

116 of 193 Prepared: October 27, 2015

245. Meyers PM, Schumacher C, Tanji K, Higashida RT, Caplan LR: Use of Stents to Treat Intracranial Cerebrovascular Disease. Annual Review of Medicine. 58: 107-122. 2007.

246. Dispensa BP, BA, David A. Saloner, PhD, Gabriel Acevedo-Bolton, PhD, Achal S. Achrol, BS, Liang-der Jou, PhD, Charles E. McCulloch, PhD, K.Y. Trudy Poon, MS, S. Claiborne Johnston, MD, PhD, Higashida RT, MD, Christopher F. Dowd, MD, Van V. Halbach, MD, Nerissa U. Ko, MD, Michael T. Lawton, MD, Alastair J. Martin, Nancy J. Quinnine, RN, William L. Young, MD. Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging. Journal of Magnetic Resonance Imaging. Volume 26; 177-183. 2007.

247. Higashida RT, Lahue B, Torbey MT, Hopkins LN, Leip E, Hanley DF: Treatment of unruptured intracranial aneurysms. A nationwide assessment of effectiveness. American Journal of Neuroradiology. Volume 28. Pages 146-151. 2007.

248. Martin AJ, Cha S, Higashida RT, Cullen SP, Halbach VV, Dowd CF, McDermott MW, Saloner DA: Assessment of meningioma vasculature and the effects of embolization with intra- arterial MR perfusion imaging. A feasibility study. American Journal of Neuroradiology. Volume 28; Pages 1771-1777. October 2007.

249. Kim H, Sidney S, McCulloch CE, Poon KYT, Singh V, Johnston SC, Ko NU, Achrol AS, Lawton MT, Higashida RT, Young WL, for the UCSF BAVM Study Project: Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Stroke. Volume 38;2430-2437. 2007.

250. Hetts S, Narvid J, Singh TJ, Meagher S, Corcoran K, Higashida RT, Dowd CF, Halbach VV: Association between lumbar epidural injection and development of acute paraparesis in patients with spinal dural arteriovenous fistulas. American Journal of Neuroradiology. 2007. Volume 28:581-583.

251. Boussel L, Dispensa B, Martin A, Higashida RT, Lawton M, Young W: Monitoring serial change in the and outer wall of vertebro-basilar aneurysms". American Journal of Neuroradiology;29;259-264; 2008.

252. Johnston SC, Dowd CF, Higashida RT, Lawton ML, Duckwiler GR, Gress DR: Predictors of re-hemorrhage after treatment of ruptured intracranial aneurysms: The Cerebral Aneurysm Re- rupture After Treatment (CARAT) Study. Stroke. Volume 39; Pages 120-125.2008.

253. Smith WS, Sung GY, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP: Mechanical thrombectomy for acute ischemic stroke: Final results of the Multi MERCI Trial. Stroke 2008; 39;1205-1212.

254. Higashida RT: Management of Carotid Stenosis: Carotid Stenting. New England Journal of Medicine. April 10, 2008:358;15, 1617-1621.

255. Ko NU, Rajendren R, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL: Endothelial nitric oxide synthase polymorphisms and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008. Volume 39:1103-1108.

256. Narvid J, Hetts SW, Larsen D, Neuhaus J, Singh TP, McSwain H, Lawton MT, Dowd CF, Higashida RT, Halbach VV: Spinal dural arteriovenous fistulae: Clinical features and long-term results. Neurosurgery 62;159-167, 2008.

117 of 193 Prepared: October 27, 2015

257. Boussel L, Rayz V, McCulloch C, Martin A, Acevedo-boulton G, Lawton M, Higashida RT, Smith WS, Young WL, Saloner D: Aneurysm growth occurs at regions of low wall shear stress: Patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke 2008.

258. Lutsep H, Rymer M, Nesbit G Vertebrobasilar Revascularization Rates and Outcomes in the MERCI and Multi-MERCI Trials. (Higashida, RT, collaborator) Journal of Stroke and Cerebrovascular Diseases, Vol. 17, No. 2 (March-April), 2008: pp 55-57.

259. Rayz VL, Boussel L, Acevedo-Bolton G, Martin AJ, Young WL, Lawton MT, Higashida RT, Saloner D: Numerical simulations of flow in cerebral aneurysms: Comparison of Computational Fluid Dynamic results and in vivo MRI measurements. Annals of . Volume 36; Issue 11; Pgs 1793-1804; Sept 2008. ISSN0090-6964 (Print) 1573-9686 (Online).

260. Elijovich L, Higashida RT, Lawton MT, Duckwiler G, Giannotta S, Johnston SC, and the Cerebral Aneurysm Re-rupture After Treatment (CARAT) Investigators. Predictors and outcomes of intra-procedure rupture in patients treated for ruptured intracranial aneurysms: The CARAT study. Stroke 2008; May:39(5):1501-1506. EPub 2008, March 6.

261. Easton DJ, Saver J, Albers GW, Johnston SC, Kidwell C, Sacco RL, Alberts MJ, Chaturvedi S, Feldmann E, Hatsukami TS, Higashida RT, Lutsep H, Miller E: Definition and Evaluation of Transient Ischemic Attack: A Scientific Statement for Professionals From the American Heart Association/American Stroke Association Stroke Council, Cardiovascular Surgery and Anesthesia Council, and the Cardiovascular Council, and the Atherosclerotic Peripheral Vascular Disease Working Group. Stroke 2009; 40:2276-2293.

262. Meyers PM, Schumacher HC, Higashida RT, Barnwell SL, Creager MA, Gupta R, McDougall CG, Pandey DK, Sacks D, Wechsler LR: Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures. A Scientific Statement From the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Circulation Online April 6, 2009; DOI: 10.1161/CIRCULATIONAHA.109.192217; CIRCULATION. 200-0:119:0-0.

263. Martin AJ, Back B, Acevedo-Bolton G, Higashida RT, Comstock J, Saloner DA: MR Imaging during Endovascular Procedures: An Evaluation of the Potential for Catheter Heating. Magnetic Resonance Imaging In Medicine. 61:45-53; 2009.

264. Hetts SW, Narvid J, Sanai N, Lawton MT, Gupta N, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV: Intracranial Aneurysms in Childhood: 27- Year Single-Institution Experience. American Journal of Neuroradiology; April 8, 2009 as 10.3174/ajnr.A1587; 1-10.

265. Nogueira RG, Smith WS and on Behalf of the MERCI and Multi MERCI Writing Committee Safety. (Higashida, RT, collaborator) Efficacy of Endovascular Thrombectomy in Patients With Abnormal Hemostasis. Pooled Analysis of the MERCI and Multi MERCI Trials. Stroke 2009 Feb;40(2):516-22.

266. Meyers PM, Schumacher HC, Alexander MJ, Derdeyn CP, Furlan AJ, Higashida RT, Moran CJ, Tarr RW, Heck DV, Hirsch JA, Jensen ME, Linfante I, McDougall CG, Nesbit GM, Rasmussen P, Tomsick TA, Wechsler LR, Wilson JR, Zaidat OO: Performance and training standards for endovascular ischemic stroke treatment: Writing Group for the American Academy of Neurology, AANS/CNS Cerebrovascular Section, Society of NeuroInterventional Surgery, and

118 of 193 Prepared: October 27, 2015

the Society of Vascular and Interventional Neurology. Journal of NeuroInterventional Surgery. Volume 1; Pages 10-12; 2009.

267. Latchaw RE, Alberts MJ, Lev MH, Connors JJ, Harbaugh RE, Higashida RT, Hobson R, Kidwell CS, Koroshetz WJ, Mathews V, Villablanca P, Warach S, Walters B: Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association. From the Special Writing Group, American Heart Association (Council on Cardiovascular Radiology and Intervention and Council on Stroke, and the Interdisciplinary Council on Peripheral Vascular Disease). Stroke. Published Online September 24, 2009. DOI: 10.1161/STROKEAHA.108.192616.

268. Schumacher HC, Meyers PM, Higashida RT, Derdeyn CP, Lavine SD, Nesbit GM, Sacks D, Rasmussen P, Wechsler LR: Reporting Standards for Angioplasty and Stent-Assisted Angioplasty for Intracranial Atherosclerosis. Journal of Vascular and Interventional Radiology 20:S451-S473; 2009. Stroke 40(5):e348-e365, 2009. Journal of NeuroInterventional Surgery ; 2:324-340; 2010.

269. Meyers PM, Schumacher C, Higashida RT, Derdeyn CP, Nesbit GM, Sacks D, Wechsler LR, Bederson JB, Lavine SD, Rasmussen P: Reporting Standards for Endovascular Repair of Saccular Intracranial Cerebral Aneurysms. Journal of Vascular and Interventional Radiology 20:S435-S450; 2009. Stroke 40(5):e366-e379. 2009. Journal of NeuroInterventional Surgery ; 2:312-323; 2010.

270. Potter CA, Armstrong-Wells J, Fullerton HJ, Young WL, Higashida RT, Dowd CF, Halbach VV, Hetts SW. Neonatal giant pial arteriovenous malformation: Genesis or rapid enlargement in the third trimester. Journal of NeuroInterventional Surgery. 1:151-153, 2009.

271. Higashida RT, Popma JJ, Apruzzese P, Zimetbaum P, Maveric I and II Investigators: Evaluation of the Medtronic Exponent Self-Expanding Carotid Stent System With the Medtronic Guardwire Temporary Occlusion and Aspiration System in the Treatment of Carotid Stenosis. Combined from the Maveric (Medtronic AVE Self-expanding CaRotid Stent System with distal protection In the treatment of Carotid Stenosis) I and Maveric II Trials. Stroke 2009. December 28, 2009. Online at: http://stroke.ahajournals.org. Issn: Online: 1524-4628. Print Issn: 0039-2499.

272. Shi ZS, Loh Y, Walker G, Duckwiler GR, and the MERCI and Multi-MERCI Investigators. (Higashida RT, collaborator). Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: Pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials. Stroke. 2010; May:41(5):953-960. Epub 2010, April 8.

273. Appelboom G, Strozyk, Meyers PM, Higashida RT: Current recommendations for endovascular interventions in the treatment of ischemic stroke. Current Atheroscler Rep (2010) 12:244-250. DOI 10.1 007/s11883-010-0115-6.

274. Brott, TG, Hobson RW, Howard G, Roubin GS, for the CREST Investigators (Higashida RT, collaborator): Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis. New England Journal of Medicine. Volume 363; No. 1; 11-23; 2010.

275. Shi ZS, Loh Y, Walker G, Duckwiler GR, and the MERCI and Multi MERCI Investigators (Higashida RT, collaborator). Endovascular thrombectomy for acute ischemic stroke in failed intravenous tissue plasminogen activator versus non-intravenous tissue plasminogen activator

119 of 193 Prepared: October 27, 2015 patients: Revascularization and outcomes stratified by the site of arterial occlusions. Stroke June:41(6):1185-1192. EPub 2010. April 29.

276. Jun P, Ko NU, English JD, Dowd CF, Halbach VV, Higashida RT, Lawton MT, Hetts SW. Endovascular treatment of medically refractory cerebral vasospasm following aneurysmal subarachnoid hemorrhage. American Journal of Neuroradiology. November 31 (10):1911-1916. Epub 2010, July 8.

277. Antonietti L, Sheth SA, Halbach VV, Higashida RT, Dowd CF, Lawton MT, English JD, Hetts SW. Long term outcome in the repair of spinal cord perimedullary arteriovenous fistulas. American Journal of Neuroradiology 2010. November;31(10):1825-1830. EPUb 2010, September 2.

278. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Frey A, Marr A, Roux S, Kassell NF: Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: Rationale and design of CONSCIOUS-2 and CONSCIOUS-3 Trials. Neurocritical Care (2010) 13: 416-424. DOI 10.1007/s12028-010-9433- 3.

279. Gorelick PB, Scuteri A, Black SE, DeCarliC, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson Pm, Roman GC, Selke FW, Seshadri S: Vascular Contributions to Cognitive Impariment and Dementia: A Statement for Healthcare Professionals from the American Heart Association/American Stroke Association Council on Stroke and Council on Epidemiology and Prevention. Co-Sponsered by the Councils on Cardiovascular Radiology and Intervention, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia. Stroke, July 21, 2011; Online ISSN: 1524-468; 2011.

280. Meyers PM, Schumacher C, Connolly ES, Heyer EJ, Gray WA, Higashida RT: Current status of endovascular stroke treatment. Circulation: 123;2591-2601. 2011.

281. Cooke D, Tatum J, Farid H, Dowd C, Higashida RT, Halbach VV. Transvenous embolization of a pediatric pial arteriovenous fistula. Journal of NeuroInterventional Surgery. 2012;4:314. (2011)July 7, EPub ahead of print)

282. Hetts SW, English JD, Dowd CF, Higashida RT, Scanlon JT, Halbach VV. Pediatric intracranial aneurysms: New and enlarging aneurysms after index aneurysm treatment or observation. American Journal of Neuroradiology. 2011. December 32(11):2017-2022. EPUb 2011, November 11.

283. Eesa M, Schumacher CH, Higashida RT, Meyers PM: Advances in revascularization for acute ischemic stroke treatment: An Update. Expert Review in Neurotherapeutics 11(8), 1125- 1139. 2011.

284. Chimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, et al for the SAMMPRIS Trial Investigators. Stenting versus Aggressie Medical Therapy for Intracranial Arterial Stenosis. (Higashida, RT, collaborator). New England Journal of Medicine. (10.1056/NEJMoa110533455); 9/7/2011. NEJM.org.

285. Alexander MD, Hetts SW, Young WL, Halbach VV, Dowd CF, Higashida RT, English JD: Supernova Hemorrhage: Obliterative hemorrhage of brain arteriovenous malformations following

120 of 193 Prepared: October 27, 2015 gamma knife radiosurgery. Journal of Neuro Interventional Surgery (2011). Doi:10.1136/neurint surg-2011-010098. September 15, 2011. JNIS 2012;4:364-367.

286. Martin AJ, Hetts SW, Dillon WP, Higashida RT, Halbach VV, Dowd CF, Lawton MT, Saloner D. MR imaging of partially thrombosed cerebral aneurysms: Characteristics and evolution. American Journal of Neuroradiology 2011. February 32(2):246-351, EPub 2010, November 18.

287. Hetts SW, Moftakhar P, English JD, Dowd CF, Higashida RT, Lawton MT, Douglas VC, Halbach VV. Spinal dural arteriovenous fistulas and intrathecal venous drainage: Correlation between digital subtraction angiography, magnetic resonance imaging, and clinical findings. Journal of Neurosurgery. Spine. 2012. May:176(5):433-440. EPub 2012. February 10.

288. Cooke D, Farid H, Kim W, Dowd C, Higashida RT, Halbach VV: Zygomatico-orbital intra- arterial melphalan infusion for intraocular retinoblastoma. Journal of Neurointerventional Surgery. Volume 4, Number 4; e-14; 2012.

289. Connolly ES, Rabinstein AA, Carhuapoma JR, Derdeyn C, Dion J, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson G, Vespa P: Guidelines for the management of aneurysmal subarachnoid hemorrhage. A Statement for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 2012. (http://stroke.ahajournals.org/content/early/2012/05/03/STR.0b013e3182587839)

290. Hetts SW, Keenan K, Fullerton HJ, Young WL, English JD, Gupta N, Dowd CF, Higashida RT, Lawton MT, Halbach VV: Pediatric Intracranial Non-Galenic Pial Arteriovenous Fistulas: Clinical Features, Angioarchitectures, and Outcomes. American Journal of Neuroradiology. 10.3174/ajnr.A3194. 2012.

291. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneus A, Raabe A, Vajkocyz P, Wanke I, Bach D, Frey A, Nowbakht P, Roux S, Kassell N: Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke. 2012. Downloaded from http://stroke.ahajournals.org/ at CONS CALIFORNIA DIG LIB on March 12,(2012http://stroke.ahajournals.org/content/early/2012/03/07/STROKEAHA.111.648980)

292. Meyers PM, Blackham KA, Abruzzo TA, Gandhi CD, Higashida RT, Hirsch JA, Moran CJ, Narayanan S, Prestigiacomo CJ, Tarr R, On behalf of the Society for NeuroInterventional Surgery. Society of NeuroInterventional Surgery Standards of Practice: General Considerations. Journal of NeuroInterventional Surgery. 4:11-15; 2012.

293. Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW: Density of on admission CT predicts revascularization efficacy in large vessel occlusion in acute ischemic stroke. Stroke; 2013; Jan; 44(1):243-245. http://stroke.ahajournals.org/content/early/2012/10/30/STROKEAHA.112.674127

294. Bendok BR, Rahme RJ, for the Complex Registry Group: Complex shaped detachable platinum coil system for the treatment of cerebral aneurysms: The Codman Trufill DCS and Trufill DCS Orbit Detachable Coil System COMPLEX Registry final results. Journal of NeuroInterventional Surgery. 2013:5:54-61. doi:10.1136/neurintsurg-2011010118.

295. Cooke DL, Meisel K, Kim WT, Stout CE, Halbach VV, Dowd CF, Higashida RT: Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary, and intra-abdominal visceral artery aneurysms in a patient presenting with

121 of 193 Prepared: October 27, 2015

subarachnoid hemorrhage and review of the literature. Journal of NeuroInterventional Surgery. 2013;5:478-482.

296. Sacco RL, Kasner SE, Broderick J, Caplan LR, Connors JJ, Culebras A, Dunn BH, Elkind MSV, George MG, Hamdan AD, Higashida R, Hoh BL, Janis LS, Kase CS, Kleindorfer D, Lee MN, Leys D, Moseley ME, Norrving B, Peterson E, Turan TN, Valderrama AL, Vinters HV; on behalf of the American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, and Council on Nutrition, Physicial Activity and Metabolism. American Heart Association/American Stroke Association Expert Concensus Document: An Updated Definition of Stroke for the 21st Century. A Statement for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44: 2064-2089. doi: 10.1161/ STR.9b913e318296aeca.

297. Ovbiagele B, Goldstein LB, Higashida RT, Howard VJ, Johnston SC, Lackland DT, Lichtman J, Mohl S, Sacco RL, Saver JL: Forecasting the future of stroke in the United States: A Policy Statement from the American Heart Association and American Stroke Association. Stroke 2013. Stroke. 2013;44:2361-2375; originally published online May 22, 2013; On Line at: http://stroke.ahajournals.org/content/44/8/2361

298. Bendok BR, Rahme RJ, for the Complex Registry Group, (Higashida, RT, collaborator): Complex shaped detachable platinum coil system for the treatment of cerebral aneurysms: The Codman Trufill DCS and Trufill DCS Orbit Detachmable Coil System COMPLEX Registry final results. Journal of NeuroInterventional Surgery 2013; 5:54-61.

299. Kansagra AP, Cooke DL, English JE, Sincic RM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Current trends in endovascular management of traumatic cerebrovascular injury. Journal of NeuroInterventional Surgery Epub 2013 Jan 15. PMID: 23322749; 2014; Jan ;6)1):47-50.doi:10.1136/neurintsurg-22012-010605.

300. Tatum J, Farid H, Cooke D, Fullerton H, Smith W, Higashida RT, Halbach VV, Dowd C: Mechanical embolectomy for treatment of large vessel acute ischemic stroke in children. Journal of NeuroInterventional Surgery 5:128-134; 2013.

301. Amans MR, Cooke DL, Vella M, Dowd CF, Halbach VV, Higashida RT, Hetts S: Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interventional Neuroradiology 2014:20(1): 106-115: PMID: 24556308.

302. Lackland DT, Elkind MSV, D'Agostino R, Dhamoon MS, Goff DC, Higashida RT, McClure LA, Mitchell PH, Sacco RL, Sila C, Smith SC, Tanne D, Tirschwell D, Touze E, Wechsler LR. On behalf of the American Heart Association Council on Stroke, Council on Epidemiology and Prevention, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing, Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group, and Council on Quality of Care and Outcomes: Inclusion of Stroke in Cardiovascular Risk Prediction Instruments. A Statement for Healthcare Professionals from the American Heart Association/American Stroke Association. http://stroke.ahajournals.org/content/early/2012/05/24/STR.0b013e31825bcdac. Stroke 2013.

303. Higashida RT, Alberts M, Alexander D, Crocco T, Demaerschalk B, Derdeyn C, Goldstein L, Jauch E, Mayer SA, Meltzer N, Peterson E, Rosenwasser RH, Saver J, Schwamm L, Summers D, Wechsler L, Wood J: Stroke Systems of Care. A Statement for Healthcare

122 of 193 Prepared: October 27, 2015

Professionals from the American Heart Association/American Stroke Association. Stroke 2013;44. On Line at: http://stroke.ahajournals.org/content/early/2013/08/29/STR.0b013e3182a6d2b2.citation

304. Losey AD, Lillaney P, Martin A, Halbach VV, Cooke DL, Dowd CF, Higashida RT, Saloner DA, Wilson MW, Saeed M, Hetts SW: Safety of retained microcatheters: An Evaluation of Radiofrequency Heating in Endovascular Microcatheters with Nitinol, Tungsten, and Polyetheretherketone Braiding at 1.5 T and 3T. Journal of Neuro Interventional Surgery. 2013;00:1–6. doi:10.1136/neurintsurg-2013-010746. 2014;6:314-319.

305. Cooke DL, Su J Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV: Endovascular biopsy: Evaluating the feasibility of harvesting endothelia cells using detachable coils. Interventional Neuroradiology. 2013 Dec;19(4):399-408. Epub 2013 Dec18. PMID: 24355142.

306. Cooke DL, Stout CE, Kim WT, Yu JP, Gu A, Jewell NP, Hetts SW, Higashida RT, Dowd CF, Halbach VV: Cerebral arterial fenestrations and their significance. Interventional Neuroradiology. 2014. (10). Jun30:20(3): 271-274. doi: 10.15274/NRJ-2014-10027. Epub 2014 Jun17, PMID: 24976087.

307. Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV: Cerebral arteriopathy associated with Arg 179 His ACTA 2 mutation. British Medical Journal. 2013. doi: 10.1136/bcr-2013-010997. JNeurointerventional Surgery. 2014 Nov; 6(9):e46.PMID: 24353327.

308. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey Al, Marr A, Roux S, Kassell N: Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2). Acta Neurochirurgica Suppl, Vol 115, 27-31; DOI 10.1007/978-3-7091-1192-5 7. 2013.

309. Alexander M, Hetts S, Meyers PM, Halbach VV, HIgashida RT, Dowd CF, Cooke D, English: Symptom differences and Pre-treatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease. American Journal of Neuroradiology. 2014. March 27. (Epub: PMID: 24627452).

310. Cooke DL, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG: Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. Journal of Neurointerventional Surgery. 2014. Dec;6(10):785-789. PMID: 24385553.

311. Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, HIgashida RT, Halbach VV, Lawton MT, Kim H. Influence of patient age on angioarchitecture of brain Arteriovenous Malformations. American Journal of Neuroradiology. AJNR Am J Neuroradiol. 2014 Mar 13. [Epub ahead of print] PMID: 24627452. Jul;35(7):1376- 1380.

312. Katzan I, Spertus J, Allen E, Bettger JP, Bravata DM, Bushnell C, Gaynor JW, Higashida R, Hinchey JA, Holloway R, Howard G, King RB, Krumholz H, Lutz BJ, Reeves MJ, Smith E, Yeh RW, on behalf of the American Heart Association Stroke Council, Council on Quality of Care and Outcomes Research, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, and Council on Clinical Cardiology. "Risk Adjustment of Stroke Outcomes for Comparing Hospital Performance. A

123 of 193

Prepared: October 27, 2015

Book Chapters Published

8. Higashida RT, Halbach VV, Hieshima GB: Percutaneous transluminal angioplasty of brachiocephalic vessels. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, 1987, pp 303-308.

9. Halbach VV, Higashida RT, Hieshima GB: Diagnosis and treatment of dural arteriovenous fistulae. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, 1987; pp 309-314.

10. Hieshima GB, Higashida RT, Halbach VV: Treatment of intracranial aneurysms by balloon embolization therapy. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, 1987 pp 315-319.

11. Halbach VV, Higashida RT, Hieshima GB: Nonsurgical treatment for AVMs. [In] Advances in Surgery for Cerebral Stroke: Ed: Jiro Suzuki, Springer Verlag, pp 203-206, 1988.

12. Tsai F, Hieshima GB, Higashida RT: Percutaneous transluminal angioplasty for the treatment of stroke. [In] Medical Therapy of Acute Stroke. (Ed) Fisher M, Publisher: Marcel Decker, Inc., New York, pp. 203 - 239, 1989.

13. Halbach VV, Higashida RT, Hieshima GB: Preliminary experience with the treatment of intracranial vasospasm by transvascular balloon angioplasty. [In] Advances in Surgery for Cerebral Stroke: Ed: Jiro Suzuki, Springer Verlag, pp 397-398, 1988.

14. Halbach VV, Higashida RT, Hieshima GB: Treatment of dural arteriovenous fistulae. [In] Advances in Surgery for Cerebral Stroke (Ed) Jiro Suzuki, Springer Verlag, pp. 577-581, 1988.

15. Higashida RT, Halbach VV, Hieshima GB: Treatment of complex intracranial aneurysms by interventional techniques, [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, pp. 357 - 360, 1989.

16. Halbach VV, Higashida RT, Hieshima GB: Interventional Neuroradiology: Recent advances. In: Perspectives in Radiology. (Ed) Helms CA. Quality Medical Publishing, Inc. St. Louis, Missouri. Volume 2, Number 1, pp. 91-114, 1989.

17. Tsai FY, Higashida RT: Intravascular Therapeutic Embolization of Acute Traumatic Vascular Lesions of the Head and Neck. [In] Emergency Interventional Radiology. Editors: Neal MP, Tisnado J, Cho S. Little, Brown, and Company. Boston, MA. Pages: 369-384, 1989.

18. Halbach VV, Higashida RT, Hieshima GB: Diagnosis and treatment of spinal vascular malformations. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, pp. 361 - 370, 1989.

19. Higashida RT, Hieshima GB, Halbach VV: Intravascular techniques for angioplasty and thrombolysis. [In] Current Neurosurgical Practice: Protection of the Brain from Ischemia. (Eds) Weinstein PR, Faden AI. Williams and Wilkins, Pages 279-284. 1990.

127 of 193 Prepared: October 27, 2015

20. Halbach VV, Higashida RT, Hieshima GB: Endovascular treatment of intracranial arteriovenous malformations and fistulas. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, pp: 483 - 488. 1990.

21. Higashida RT, Halbach VV, Cahan LD, Brant-Zawadzki MB, Barnwell SL, Dowd CF, Hieshima GB: Transluminal angioplasty for treatment of intracranial arterial vasospasm. In: Cerebral Vasospasm: Proceedings of the IVth International Conference on Cerebral Vasospasm. Edited by: Sano K, Takakura K, Kassell NF, Sasaki T. University of Tokyo Press. Pages 421 - 428. 1990.

22. Higashida RT, Halbach VV, Dormandy B, Bell J, Hieshima GB: Endovascular treatment of cerebral vascular disease: Intracranial aneurysm therapy. Interventional Neuroradiology. Elsiever Science Publishers B. V. Biomedical Division. Radiology. J.M. Bigot et. al., editors. Pages 535-540, 1990.

23. Tsai FY, Higashida RT: Balloon transluminal angioplasty of the carotid artery in the head and neck. In: Prevention of Stroke. (Ed) Norris, JW and Hachinski VC.. Springer-Verlag, New York, New York, 1991; pages 205-218.

24. Higashida RT, Halbach VV, Hieshima GB: Treatment of intracranial aneurysms by interventional neurovascular techniques. In: Current Practice of Interventional Radiology. (Ed) Kadir S., B. C. Decker, Inc. Philadelphia, PA. Pages: 150-154. 1991.

25. Halbach VV, Higashida RT, Hieshima GB: Treatment of intracranial and extracranial vascular malformations by interventional neurovascular techniques. In: Current Practice of Interventional Radiology. (Ed) Kadir S., B. C. Decker, Inc. Philadelphia, PA. Pages: 146- 150. 1991.

26. Higashida RT: Treatment of intracranial arterial vasospasm by percutaneous transluminal angioplasty techniques. (Ed) Ohta, T. In: Proceedings from the Sixth Annual Meeting of the International Symposium for Cerebral Vasospasm. Volume 6:155-165. 1991.

27. Guillaumin B, Higashida RT: Interventional neuroradiology in treating lesions of the skull base, ear, and brain. [In] Neurological Surgery of the Ear. Editors: Smith MFW, McElveen JT. St. Louis, C.V. Mosby Co., Pages 11-18, 1992.

28. Halbach VV, Higashida RT, Hieshima GB: Endovascular therapy of dural fistulas. (Ed) Vinuela F. Raven Press. In: Endovascular therapy in the Central Nervous System. Pages 29- 50 1992.

29. Halbach VV, Higashida RT, Hieshima GB: Endovascular therapy of Head and Neck Tumors. (Ed) Vinuela F. Raven Press. In: Endovascular therapy in the Central Nervous System. Pages 17-28. 1992.

30. Tsai FY, Higashida RT: Percutaneous transluminal angioplasty of the carotid and vertebral artery. In Treatment of Stroke. (Ed) Jang GD. 1992.

31. Higashida RT, Halbach VV, Hieshima GB: Endovascular therapy of intracranial aneurysms. (Ed) Vinuela F. Raven Press. In: Endovascular therapy in the Central Nervous System. Pages 51-62. 1992.

128 of 193 Prepared: October 27, 2015

32. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB: Transluminal angioplasty for vascular lesions of the head and neck. [In] Diagnostic Radiology, (Ed) Gooding CA, University of California Printing Services, pages 491-500. 1992.

33. Tsai FY, Higashida RT, Meoli C: Percutaneous transluminal angioplasty of Extracranial and Intracranial Artery Stenosis in the Head and Neck. (Ed) Vinuela F, Dion J, Duckweiler G. In: Neuroimaging Clinics of North America. Volume 2, Number 2, pages 371-384. W.B. Saunders Company. 1992.

34. Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Intravascular surgery for aneurysms of the posterior fossa. In Proceedings of the 50th Annual Meeting of the Japanese Congress of Neurosurgery. (Ed) Kikuchi H. 1992

35. Halbach VV, Dowd CF, Hieshima GB, Higashida RT,: Traumatic vascular injuries of the head and neck: Angiographic assessment, and endovascular management. [In] Diagnostic Radiology, (Ed) Margulis AR, Gooding CA, University of California Printing Services, pages 479-490, 1992.

36. Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Endovascular treatment of complex cerebral aneurysms. In Proceedings of the 50th Annual Meeting of the Japanese Congress of Neurosurgery. (Ed) Kikuchi H. 1992.

37. Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Transluminal angioplasty for intracranial arterial vasospasm in impending stroke. In Proceedings of the 21st Japanese Conference on Surgery for Cerebral Stroke. (Ed) Kanno, T. 1992

38. Dowd CF, Halbach VV, Higashida RT, Fraser KW, Smith TP, Teitelbaum GP, Hieshima GB: PreOperative evaluation of skull base tumors: The role of the neuroangiographer. In Johnson JT and Didolkar MS (editors). Head and Neck Cancer, Volume III: Proceedings of the Third International Conference on Head and Neck Cancer, San Francisco, July 26-30, 1992. Elsevier, 1993, Amsterdam, pages 683-686.

39. Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB: Percutaneous transluminal angioplasty for cerebrovascular atherosclerotic disease. In Proceedings of the 21st Japanese Conference on Surgery for Cerebral Stroke. (Ed) Kanno, T. 1992.

40. Dowd CF, Halbach VV, Higashida RT, Hieshima GB: Diagnostic and therapeutic angiography. In: Textbook of Neurotology. Ed. Jackler RK and Brackmann DE. Mosby Year Book, Hanover, Maryland. 1993.

41. Hieshima GB, Higashida RT, Halbach VV: Intravascular treatment of Aneurysms and Angioplasty of arterial vasospasm. In: Endovascular Interventional Neuroradiology. Current Perspectives in Neurosurgery Series. Editor: Holtzman RN. Springer-Verlag, New York. Chapter 15. 1993.

42. Dowd CF, Halbach VV, Higashida RT, Hieshima GB: Angiographic evaluation of pulsatile tinnitus. In: Diagnostic Radiology, (Ed) Arenson R, Gooding CA, University of California Printing Services, pp. 115-129, 1993.

43. Halbach VV, Dowd CF, Higashida RT, Hieshima GB: Transcranial ultrasound. In Gooding CA (editor), Diagnostic Radiology 1993. University of California Printing Services, 1993, San Francisco, California, pages 115-129.

129 of 193 Prepared: October 27, 2015

44. Barnwell SL, Dowd CF, Higashida RT, Halbach VV, Hieshima GB: Endovascular therapy for cerebral arteriovenous malformations. In: Brain Surgery: Complications, Avoidance, Management. Ed: Apuzzo MJ. Churchill Livingston. Pages 1225-1246. 1993.

45. Higashida RT, Tsai FY: Percutaneous transluminal angioplasty of the vertebral and basilar arteries. Volume 2. Section VIII: Extracranial Arterial Disease. (Ed) Strandness DE, van Breda A. In: Vascular Diseases: Surgical and Interventional Therapy. Churchill Livingstone, New York. Pages 651-658. 1994.

46. Tsai FY, Higashida RT: Percutaneous transluminal angioplasty of the carotid and intracerebral arteries. Volume 2. Section VIII: Extracranial Arterial Disease.(Ed) Strandness DE, van Breda A. In: Vascular Disease: Surgical and Interventional Therapy. Churchill Livingstone, New York. Pages 659-670. 1994.

47. Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Intracranial Aneurysms: Evolution and Future Role of Endovascular Techniques. In: Endovascular Approach to Central Nervous System Disease. Neurosurgery Clinics of North America. Editor: Hopkins, LN. Volume 5, Number 3, pages 413-426. July 1994.

48. Dowd CF, Halbach VV, Higashida RT, Hieshima GB: PreOperative angiographic evaluation of skull base tumors. In Diagnostic Radiology 1994. Editor: Gooding CA. University of California Printing Services, San Francisco, 1994. pp 733-740.

49. Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB: Interventional neurovascular approaches to the basilar and vertebral arteries. In: Skull Base Surgery. Editor: Samii M. Basel, Karger, 1994, pp 686-689.

50. Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB: Sellar and parasellar region: Interventional approach to the cavernous sinus. In: Skull Base Surgery. Editor: Samii M. Basel, Karger, 1994, pp 447-450.

51. Dowd CF, Halbach VV, Higashida RT, Hieshima GB: Endovascular treatment of Vein of Galen Malformations. In: Neurosurgical Clinics. 1994.

52. Teitelbaum G, Higashida RT: Cerebrovascular Angiography. In: Vascular Diagnostics. Editor: Lanzer P. Springer Verlag, Berlin, Heidelberg. Pages 207-241. 1994.

53. Halbach VV, Hieshima GB, Dowd CF, Higashida RT: Treatment of intracranial aneurysms with electrolytically detachable coils. [In] Diagnostic Radiology, (Ed) Arenson R, Gooding CA, University of California Printing Services, 1994.

54. Dowd CF, Higashida RT, Halbach VV, Smith TP, Fraser KW, Hieshima GB: Standard and giant aneurysms: The role of endovascular therapy. In Pasqualin A, DA Pian R (editors). New Trends in Management of Cerebro-Vascular Malformations. Springer Verlag, 1994. Vienna/New York.

55. Dowd CF, Higashida RT, Halbach VV, Fraser KW, Smith TP, Hieshima GB: Angioplasty of cerebral vasospasm. In Pasqualin A, DA Pian R (editors). New Trends in Management of Cerebro-Vascular Malformations. Springer Verlag, 1994. Vienna/New York.

56. Dowd CF, Halbach VV, Higashida RT, Smith TP, Fraser K, Hieshima GB: Dural arteriovenous fistulas: the role of endovascular therapy. In Pasqualin A, DA Pian R (editors).

130 of 193 Prepared: October 27, 2015

New Trends in Management of Cerebro-Vascular Malformations. Springer Verlag, 1994. Vienna/New York.

57. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Larsen D, McDougall CG, Hieshima GB. Angioplasty of the brachiocephalic and intracranial arteries. In: Proceedings of the 10th Annual Endovascular Neurosurgical Society. Editor: Tanaka R, Koike T. Tokyo, Japan. Pages 1-9. 1994.

58. Dowd CF, Halbach VV, Higashida RT, Fraser KW, Smith TP, Hieshima GB: Endovascular management of Vein of Galen malformations. In Pasqualin A, DA Pian R (editors). New Trends in Management of Cerebro-Vascular Malformations. Springer Verlag, 1994. Vienna/New York.

59. Hieshima GB, Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Dormandy B, Bell J: Intravascular treatment of aneurysms and angioplasty of arterial spasm. In: Endovascular Interventional Neuroradiology. Editor: Robert N. Holtzman. Springer Verlag, New York. Pages 312-335. 1994.

60. Smith T, Higashida RT: NeuroInterventional Radiology: Embolotherapy Intra-axial. In: Abrams Angiography. Volume III, 4th Ed: Editors: Baum S, Pentecost MJ. Little, Brown, and Company, Boston. MA. 1995.

61. Fraser K, Higashida RT, Halbach VV, Dowd CF, Hieshima GB: Interventional Therapy for Intracranial Arteriovenous Malformations. In: Cerebrovascular Disease: Imaging and Interventional Treatment Options. Ed: Rumbaugh CL, Wang A, Tsai FY, Igaku-Shoin. New York, Tokyo. 439-459. 1995.

62. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB: Interventional Treatment of Intracranial Aneurysms. In: Cerebrovascular Disease: Imaging and Interventional Treatment Options. Ed: Rumbaugh CL, Wang A, Tsai FY, Igaku-Shoin. New York, Tokyo. 460-469. 1995.

63. Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB: Interventional neurovascular techniques in acute thrombolytic therapy for stroke. [In] Thrombolytic Therapy in Acute Ischemic Stroke III. (Ed) Yamaguchi T, Mori E, Minematsu K, del Zoppo GJ. Springer Verlag, Tokyo, Japan. Pages 294-300. 1995.

64. Larsen DW, Higashida RT, Halbach VV, Dowd CF, McDougall CG, Hieshima GB. Carotid Artery Cavernous Sinus Fistulas. In: Endovascular Neurological Intervention. American Association of Neurological Surgeons. Editor: Maciunas RJ. Oak Ridge, Illinois. Pages 125- 138. 1995.

65. Halbach VV, Higashida RT, Larsen DW, Dowd CF, McDougall CG, Hieshima GB, Wilson CB. Treatment of dural arteriovenous fistulas. In: Endovascular Neurological Intervention. American Association of Neurological Surgeons. Editor: Maciunas RJ. Oak Ridge, Illinois. Pages 217-246. 1995.

66. Tsai FY, Higashida RT. Thrombolytic treatment of acute stroke. Proceeding of the American Society of Interventional and Therapeutic Neuroradiology. Ed. Eskridge JM. Pg. 31- 36. 1995.

67. Higashida RT, Halbach VV, Dowd CF, McDougall C, Larson D, Hieshima GB: Interventional neurovascular treatment of giant intracranial aneurysms. Proceedings of the XV

131 of 193 Prepared: October 27, 2015

Symposium Neuroradiologicum. Eds. Takahashi M, Korogi Y, Moseley I. Springer-Verlag Berlin, Germany. Pages 421-422. 1995.

68. Higashida RT, Tsai FY, Halbach VV, Dowd CF, McDougall C, Larson D, Hieshima GB: Percutaneous transluminal angioplasty of extra and intracranial cerebral vascular disease. Proceedings of the XV Symposium Neuroradiologicum. Eds. Takahashi M, Korogi Y, Moseley I. Springer-Verlag Berlin, Germany. Pp. 449-450. 1995.. 1995.

69. Tsai FY, Higashida R, Matovich V, Gurley M, Garby K: Thrombolytic treatment of acute vertebrobasilar artery occlusion. Proceedings of the XV Symposium Neuroradiologicum. Eds. Takahashi M, Korogi Y, Moseley I. Springer-Verlag Berlin, Germany. Pp. 466-468. 1995.

70. Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. Transluminal angioplasty, thrombolysis, and stenting for cerebral vascular disease. In: Advances in Interventional Neuroradiology and Intravascular Neurosurgery. Editors: Taki W, Picard L, Kikuchi H. Elsevier Science BV. Amsterdam, Netherlands. Pages 369-373. 1996

71. Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB. Thrombolytic therapy in acute stroke. In: Advances in Interventional Neuroradiology and Intravascular Neurosurgery. Editors: Taki W, Picard L, Kikuchi H. Elsevier Science BV. Amsterdam, Netherlands. Pages 453-457. 1996.

72. Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Interventional treatment of giant intracranial aneurysms: Technical strategies and results. In: Advances in Interventional Neuroradiology and Intravascular Neurosurgery. Editors: Taki W, Picard L, Kikuchi H. Elsevier Science BV. Amsterdam, Netherlands. Pages 153-157. 1996.

73. Dowd CF, Halbach VV, Higashida RT, Hieshima GB. Angiography of the Nervous System. In: Principles of Child Neurology. Editor Berg BO. McGraw-Hill, New York. Pages 87-112. 1996.

74. Higashida RT, Malek AM, Phatouros CC, Lempert TE, Dowd CF, Meyers PM, Halbach VV: Stenting and Angioplasty for Cerebrovascular Disease. In: Prevention of Ischemic Stroke. Editors: Fisher M and Fieschi C. Martin Dunitz Publishers, London, Pages 231-252. 1999.

75. Urwin RW, Higashida RT, Halbach VV, Dowd CF, Balousek PA, Hieshima GB: Endovascular Therapy for the Carotid Artery. In: Neuroimaging Clinics of North America. Imaging of Carotid Artery Disease. Editor: Heiserman JE. W.B. Saunders, Philadelphia. Volume 6. Number 4. Pages 957-974. November 1996.

76. Konishi Y, Halbach VV, Higashida RT, Dowd CF, Larson DW, McDougall CG, Derugin N, Hieshima GB. Evaluation of acute thrombogenesis following microcoil aneurysm treatment in swine. In: Advances in Interventional Neuroradiology and Intravascular Neurosurgery. Editors: Taki W, Picard L, Kikuchi H. Elsevier Science BV. Amsterdam, Netherlands. Pages 45-50. 1996.

77. Halbach VV, Dowd CF, Higashida RT, Hieshima GB. Transvenous coil treatment of carotid cavernous sinus fistulas. In: Carotid Cavernous Fistulas. Editor: Tomsick, Thomas. Publisher. Digital Educational Publishing, Inc. Pages 163-176, 1997.

78. Balousek PA, Dowd CF, Halbach VV, Higashida RT, Gress DR: Intensive care management of children undergoing neurointerventional procedures. In: Pediatric Neurosurgical

132 of 193 Prepared: October 27, 2015

Intensive Care: Neurosurgical Topics. Editor: Andrews BT. The American Association of Neurological Surgeons. Pages 175-198. 1997.

79. Larsen D, Higashida RT: Treatment of Carotid-Cavernous Sinus Fistulae." In: Practice of Interventional Neuroradiology. Editors: Connors, JJ, Wojak JC. W.B. Saunders Company, Philadelphia, Pennsylvania. Chapter 19, pages 215-226. 1997.

80. Dowd CF, Hieshima GB, McDougall CM, Higashida RT, Halbach VV, Dowd CF, Larsen DW: Intracranial Angioplasty: Current Use, Limitations, Future Implications." In: Cerebrovascular Disease. Lippincott-Raven Publisher. Editor: H. Hunt Batjer. Chapter 44, pages 547-558, 1997.

81. Shibuya M, Higashida RT, Kuhn D: Operative and Interventional Neuroradiology. In: Emergency Management and Critical Care of Stroke. Book Series: Update in Intensive Care and Emergency Medicine. Editors: Hacke W, Hanley D, Steiner T. Springer Verlag, Germany. Pages 146-155. 1998.

82. Marler JR, Fieschi C, Higashida RT, Boysen G: Thrombolytic Therapy in Acute Ischemic Stroke. In: In: Emergency Management and Critical Care of Stroke. Book Series: Update in Intensive Care and Emergency Medicine. Editors: Hacke W, Hanley D, Steiner T. Springer Verlag, Germany. Pages 75-83. 1998.

83. Malek AM, Halbach VV, Dowd CF, Higashida RT: Diagnosis and Treatment of Dural Arteriovenous Fistulas. In: Neuroimaging Clinics of North America. WB Saunders Company. Philadelphia, Pennsylvania. Volume 8, Number 2, Pages 445-468; May 1998.

84. Furlan T, Higashida RT: Thrombolytic therapy for stroke. In: Current Clinical Neurology. Editor: Lyden, Patrick D. The Humana Press Inc. Totowa, New Jersey. 1998.

85. Malek AM, Halbach VV, V, Higashida RT, Phatouros CP, Meyers, PM, Dowd CF: Treatment of dural arteriovenous malformations and fistulas. Neurosurgery Clinics of North America. Editor: Mayberg MR, Winn HR.. W.B. Saunders. Philadelphia, Pennsylvania. Volume 11; Number 1; January 2000. Pages 147-166.

86. Hopkins LN, Higashida RT , Piepgras D: Perspectives on Training Standards in Neuroendovascular Therapeutics. Neurosurgery Clinics of North America. Editor: Mayberg MR, Winn HR.. W.B. Saunders. Philadelphia, Pennsylvania. Volume 11; Number 1; January 2000. Pages 187-190.

87. Phatouros CC, Higashida RT, Malek AM, Meyers PM, Dowd CF, Halbach VV: Endovascular Treatment of Non-Carotid Extracranial Cerebrovascular Disease. In: Neurosurgical Clinics of North America. Editor: Harbaugh R. W.B. Saunders. Philadelphia, Pennsylvania. Volume 11, Number 2, April 2000. Pages 1-20.

88. Phatouros CC, Meyers PM, Dowd CF, Malek AM, Halbach VV, Higashida RT: Carotid artery cavernous fistulas. Neurosurgery Clinics of North America. Editor: Mayberg MR, Winn HR.. W.B. Saunders. Philadelphia, Pennsylvania. Volume 11; Number 1; January 2000. Pages 67-84.

89. Mitchell P, Higashida RT, Dowd CF, Halbach VV: Percutaneous techniques in central nervous system disorders. In: Theory and Practice of Vascular Medicine. Editor: Tierstein P. 2001.

133 of 193

Prepared: October 27, 2015

Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis and Therapy. Springer-Verlag, Heidelberg. Pages 252-271. 2002.

102. Schumacher HC, Meyers P, Bateman B, Higashida RT: Elective Endovascular Revascularization of the Intracerebral Cerebral Arteries. In: Angioplasty and Stenting of Carotid and Supra-Aortic Trunks". Editors: Henry M, Polydorou A, Kiskinis D. Nancy, France. 2002.

103. Schumacher HC, Meyers P, Mohr JP, Higashida RT: Elective Angioplasty and Stenting for Intracranial Atherosclerotic Stenosis. In; Carotid Artery stenting: Current Practice and Techniques. Editors: Al-Mubarak N, Roubin GS, Iyer SS, Vitek J. Lippincott, Williams, and Wilkins. Pages 255-289. 2004.

104. Higashida RT, Malek AM, Dowd CF, Halbach VV: Neuroendovascular Surgical Procedures for Intracranial Ischemic Cerebrovascular Disease. In: Textbook of Neurological Surgery. Editors: Batjer H, Loftus C. Lippincott, Williams, and Wilkins. New York, New York. Volume 3: Pages 2311-2318. 2002.

105. Caragine L, Halbach VV, Ng P, Dowd CF, Higashida RT: Endovascular Treatment of Spinal Cord Vascular Malformations. In: Seminars in Cerebrovascular Surgery: Spinal Cord Vascular Malformations. Editor: Pritz MB. 2002.

106. Meyers P, Higashida RT: Management of Carotid-Cavernous Fistulas and Dural Arteriovenous Fistulas. In: Endovascular Surgery: Progress in Neurological Surgery. Editor: Horowitz MB. Karger Press. 2002.

107. Yousry T, Higashida RT: Interventional Neuroradiology in the Brain, Head, and Neck Region. In: Neurological Disorders: Course and Treatment, Second Edition. Editors: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C. Academic Press. Elsevier Science. San Diego, CA. Pages 481-516. 2003.

108. Phatouros CC, Higashida RT, Lefler JE, Malek AM, Meyers PM, Dowd CF, Halbach VV: Angioplasty and Stent Placement in the Extracranial Circulation. In: Endovascular and Percutaneous Therapy of the Brain and Spine. Editors: Marks MP, Do HM. Lippincott Williams and Elkins. Philadelphia, Pennsylvania. Pages 43-74. 2002.

109. Weber OM, Saeed M, Martin AJ, Moore P, Higashida RT, Schalla S, Kuehne T, Lee R, Higgins CB: Early Experience with Combined MR and X-Ray Suites. In: Cardiovascular Magnetic Resonance: Established and Emerging Applications. Fayad Z, Lardo A: Editors. 2003.

110. Dowd CF, Halbach VV, Higashida RT: Diagnostic and Therapeutic Angiography. In: Textbook of Neurotology. Second Edition. Editors: Jackler R, Brickman. Elsevier Science, Philadelphia, Pennsylvania. Part IV: Neuroradiology. Pages 436-468. 2005.

111. Roberts HC, Roberts TPL, Higashida RT: Magnetic Resonance Imaging. In: Imaging Cerebrovascular Disease. Editors: Babikian V, Wechsler L, Higashida RT. Lippincott, Williams and Wilkins, Philadelphia, Pennsylvania. Pages 159-172. 2003.

112. Schumacher HC, Meyers PM, Bateman B, Higashida RT: Elective Endovascular Revascularization of the Intracranial Cerebral Arteries. In: Angioplasty and Stenting of the Carotid and Supra-aortic trunks. Editor: Henry Michael, Ohki T, Polydorou A, Strigaris K,

135 of 193 Prepared: October 27, 2015

Kiskinis D. London: Taylor & Francis, Martin Dunitz Publishers: 2004. Martin Dunitz Publishers.

113. Meyers PM, Lavine SD, Higashida RT: Endovascular Revascularization of Carotid Artery Disease. In: Controversies in Neurological Surgery: Neurovascular Diseases. Editors: Lawton M, Gress D, Higashida, RT. Thieme Medical Publishers & the American Association of Neurological Surgeons. New York, and Rolling Meadows, Illinois. 2006. Pages 182-195.

114. Furlan AJ, Higashida RT: Intra-arterial Thrombolysis in Acute Ischemic Stroke. In: Stroke: Path physiology, Diagnosis, and Management. Fourth Edition. Editors: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA. Churchhill Livingstone, Elsiever Press. Philadelphia, Pennsylvania. 2004. Chapter 49. Pages 943-952.

115. Furlan AJ, Higashida RT, Katzen I, Abou-Chebl A, Russman AN: Intra-Arterial Thrombolysis In Acute Ischemic Stroke. Editor: Lyden P. In: Thrombolytic Therapy For Acute Stroke. Second Edition. Humana Press. Ottawa, New Jersey. Pages 159-184. 2005.

116. Fang L, Meyers PM, Higashida RT: Treatment of Dural Arteriovenous Fistulas. In Horowitz M and Levy M (eds): Neuroendovascular Surgery. Progress in Neurological Surgery. Basel, Karger, 2004, Volume 17., Pages 160-179.

117. Dowd CF, Halbach VV, Higashida RT: Neurointerventional Techniques. In: Textbook of Neuro-Oncology. Editors: Berger MS, Prados MD. Publisher: Elsevier Saunders. Philadelphia, Pennsylvania. Chapter 12, Pages 80-86. 2005.

118. Furlan AJ, Katzan I, Abou-Chebl A, Higashida RT: Thrombolytic therapy in Acute Ischemic Stroke. Editors: Latchaw RE, Kucharczyk J, Moseley ME. In: Imaging of the Nervous System. Elsevier Mosby, Philadelphia, Pennsylvania. Pages 463-472. 2005.

119. Higashida RT, Meyers PM, Connors JJ, Sacks D. Intracranial Revascularization Therapies. In: Cerebrovascular Update: Current Practices and Future Trends. Ed: Singh V. 2005.

120. Higashida RT. Endovascular Treatment Of Hemorrhagic Brain Diseases. In: Cerebrovascular Update: Current Practices and Future Trends. Ed: Singh V. 2005.

121. Cullen SP, Higashida RT: Endovascular treatment of extracranial carotid artery stenosis: Update on carotid angioplasty and stenting. In: Neuro Imaging Clinics of North America: Stroke I: Overview and Current Clinical Practice. Editor: Lev MH. Volume 15, Number 2, May 2005. Pages: 383-397.

122. Temes RE, Schumacher HC, Meyers PM, Higashida RT: Intracerebral and Carotid Angiography. In: A Primer on Risk Stratification and Management of Patients with Asymptomatic Carotid Artery Disease. Editors: Moussa I, Rundek T, Mohr JP. 2006.

123. Hwang SW, Higashida RT, Malek AM. Fundamentals of Operative Techniques in Neurosurgery: Embolization of Meningiomas. 2007.

124. Gelb AW, Higashida RT: Occlusive Cerebrovascular Disease: Anesthetic Considerations. In: Cottrell's Neuroanesthesia, Fifth Edition. Editor: Cottrell JE and Young B. Elsevier, Mosby Inc. 2009.

136 of 193 Prepared: October 27, 2015

125. Furlan AJ, Sharma J, Higashida RT: Intra-arterial Thrombolysis in Acute Ischemic Stroke. Mohr J (editor). Elsever. In Stroke 2011. Chapter 62. Pages 1227-1240.

126. Eesa M, Higashida RT, Meyers PM: Intracerebral Interventions for Acute Ischemic Stroke. In: Handbook of Endovascular Periopheral Interventions. Editors: Owens CD, Yeghiazarians Y. Springer- New York. Pages 193-214. 2012.

127. Strozyk D, Schumacher C, Meyers PM, Higashida RT: Elective endovascular reascularization of the intracranial cerebral arteries. "The Carotid and Supra-Arotic Trunks: Diagnosis, Angioplasty, and Stenting, First Edition by Michel Henry, Edward Dietrich, Antonios Polydorou. 2011 Balckwell Publishing Ltd., 2011. Pages 392-411.

128. Higashida RT: Intra-arterial Thromboloysis in Acute Ischemic Stroke and Mechanical Revascularization. In Stroke, 5th Edition. Editor: J.P. Mohr. Elsevier Press. 2011. Philadelphia, Pennsylvania.

129. Ellis JA, Goldstein H, Higashida RT, Meyers PM: Endovascular Treatment of Vein of Galen Malformations. In: Neurovascular Surgery, 2nd Edition; Editors: Spetzler R, Higashida RT. 2012.

130. Cohen ER, Meyers PM, Lavine SD, Higashida RT: Historical Account of Interventional Neuroradiology. Catheter-Based Cardiovascular Interventions. P. Lanzer (editor). DOI 10.1007/978-3-642-27676-7_3, Springer Verlag, Berlin Heidelberg, 2013.

131. Herrick IA, Chui J, , Higashida RT, Gelb AW: Occlusive Cerebrovascular Disease: Anesthetic Considerations. In: Cottrell's Neuroanesthesia, Sixth Edition. Editor: Cottrell JE and Young B. Elsevier, Mosby Inc. 2015.

132. Bruno C, Meyers PM, Higashida RT: Endovascular treatment of supratentorial arteriovenous malformations. In: Comprehensive Management of Arteriovenous Malformation of the Brain and Spine. Editors: Spetzler RF, Kondziolka DS, Higashida RT, Kalani MYS. Cambridge University Press. 2015. Pages 208-217.

133. Ellis JA, Goldstein H, HIgashida RT, Meyers PM: Endovascular treatment of Vein of Galen malformations. In: Neurovascular Surgery, Second Edition. Chapter: Cerebral Spinal Arteriovenous Fistulas and Malformations. Editor: Spetzler, R. Pages: 900-907. Cambridge University Press. 2015.

134. Ellis JA, Higashida RT, Meyers PM: Vein of Galen Malformations. In: Neurosurgical Operative Atlas: Vascular Neurosurgery. 3rd Edition. Editor: Macdonald, RL. Thieme Publishers. New York, New York. 2015.

Other Publications

1.

Abstracts, Editorials, Book Reviews

2. Higashida RT, Hyman A, Kadowitz P: Pulmonary hypertensive response to adenosine diphosphate: Role of prostaglandins. Clinical Research 26(1):61a, 1978.

137 of 193 Prepared: October 27, 2015

3. Higashida RT, Spannhake E, Kadowitz P, Hyman A: Selective precapillary hypoxemia causes pulmonary vasoconstriction. Circulation 58(4), 1978.

4. Hyman A, Chapnick B, Feigen L, Higashida RT, Kadowitz P: Pulmonary vascular responses to Angiotensin I, II, and III in intact cats. Circulation 58(4), 1978.

5. Higashida RT, Diament MI, Berquest W, Kangarloo H: Complications of long-term pediatric parenteral nutrition: Role of ultrasound. American Journal of Roentgenology 141:849-850, 1983.

6. Hieshima GB, Higashida RT: Intracranial Embolotherapy: Treating aneurysms by balloon embolization therapy. Diagnostic Imaging 2:90-94, 1986.

7. Wapenski JA, Hieshima GB, Higashida RT, Bentson JR, Halbach V: Neurologic evaluation of patients during intravascular balloon for posterior cerebral circulation aneurysms. Neurology 36(4):143, 1986.

8. Hieshima GB, Higashida RT: Aneurysm neck remnant following balloon embolization. Editorial Response. Journal of Neurosurgery 67(2):321-323, 1987.

9. Yang PJ, Halbach VV, Higashida RT, Hieshima GB, Flom RA, Seeger JF: Interventional neuroradiology. Brain Research Institute, Volume 4, No. 3, pp 15-20, 1988.

10. Hieshima GB, Higashida RT, Halbach VV: Intravascular detachable balloon embolization of intracranial aneurysms. Western Journal of Medicine 149:3, 323, 1988.

11. Higashida RT, Halbach VV, Hieshima GB, Tsai F: Percutaneous transluminal angioplasty of the vertebral and basilar artery: Editorial response. American Journal of Neuroradiology 9:607-608, 1988.

12. Higashida RT, McLaughlin P, Halbach VV, Hieshima GB: Interventional techniques alter neuroradiology's role. Diagnostic Imaging, 10:114-118, 1988.

13. Cahan LD, Higashida RT, Halbach VV, Hieshima GB: Balloon embolization of posterior circulation aneurysms. Editorial Response. Journal of Neurosurgery. Volume 72:6: 984-985. June 1990.

14. Higashida RT, Halbach VV, Hieshima GB, Cahan L: Detachable balloon embolization for intracranial aneurysms: Editorial Response. Journal of Neurosurgery. Volume 73. Number 1: 157-159, July 1990.

15. Higashida RT: Endovascular Neurosurgery: The marriage of imaging and intravascular therapy in the decade of the brain. Western Journal of Medicine. February 1993. Volume 158:2, 197-199.

16. Higashida RT: Book Review of NeuroAngiography. In American Journal of Neuroradiology. Volume 14, Number 4, 1993.

17. Higashida RT, Hieshima GB, Halbach VV: Advances in the treatment of complex cerebrovascular disorders by interventional neurovascular techniques. Images, Volume 12, Number 3, pp 1-9. 1993.

138 of 193 Prepared: October 27, 2015

18. Halbach VV, Higashida RT, Dowd CF, Hieshima GB: Endovascular alleviation of deficits. Editorial reply. Journal of Neurosurgery. Volume 82: 909-910, 1995.

19. del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Gent M, Driscoll RM, and the PROACT Investigators: The Prolyse in Acute Cerebral Thromboembolism Trial (PROACT): Results of 6 mg dose tier. Stroke, 1996; 27:164.

20. Higashida RT: Advances in the endovascular treatment of intracranial aneurysms. Journal of Endovascular Surgery 1997; 4:1-I48-49.

21. Halbach VV, Higashida RT, Dowd CF: Comment to Transvenous embolization of dural AVFs. Neurosurgery, Vol 40, No. 6, 1142; 1997.

22. Higashida RT: Retrievable versus Non-retrievable Coils: Letter to the Editor. American Journal of Neuroradiology. Volume 18: Number 7: 1389-1390. 1997.

23. Higashida RT: Catheter-Directed Intra-Arterial Thrombolysis in Acute Stroke Therapy Management. In: Thrombolysis Update. Editor: Sasahara A. March 1998. Volume 1, Issue1. Pages 5-8.

24. Phatouros CC, Higashida RT, Halbach VV: New methods of treatment for cerebral aneurysms. Western Journal of Medicine. September1998; Volume 169, Number 5: 286-287. .

25. Del Zoppo GJ, Higashida RT, Furlan AJ, Rowley HA, Gent M: Response to Letters to the Editor: "Intra-arterial Pro-urokinase in Ischemic Stroke". Stroke 1998;29:1255-1256.

26. Malek AM, Higashida RT: Editorial Reply: Treatment of an intracranial aneurysm using a new three-dimensional shape Guglielmi detachable coil: Technical case report. Response. Journal of Neurosurgery. Volume 45, Number 4, pg 959-961. 1999.

27. Higashida RT: Review of: Short Term arteriographic and clinical outcome after cerebral angioplasty and stenting for intracranial vertebrobasilar and carotid atherosclerotic occlusive disease. Journal Watch: Neurology. 2000.

28. Higashida RT: "Angioplasty with Stenting for Intracranial Stenosis: Does It Work?". In Journal Watch: Neurology. Volume 2, Number 5, Page 38. New England Journal of Medicine. May 2000.

29. Higashida RT: Commentary Entitled: A few personal anecdotes on neuroradiology and interventional neuroradiology. By Gerard Debunk. Surgical Neurology. 2000.

30. Higashida RT, Connors JJ: "Should Interventional Radiologist Be Involved In Acute Stroke Therapy?". Journal of Vascular and Interventional Radiology. February 2001; Volume 12.

31. Higashida RT, Hopkins NL: Program Requirements for Endovascular Neurosurgery/Interventional Neuroradiology. Editorial Reply. Neurosurgery, Volume 48, Number 2, February 2001.

32. Phatouros CC, Meyers PM, Higashida RT, Malek AM, Lempert TE, Dowd CF, Halbach VV: Intracranial hemorrhage and cerebral hyperperfusion syndrome following stenting of extracranial carotid artery stenosis: Letter to the Editor. American Journal of Neuroradiology. 2001.

139 of 193 Prepared: October 27, 2015

33. Higashida RT, Tomsick T: Meeting Summary: Annual Scientific Meeting of the American Society of Interventional and Therapeutic Neuroradiology and the Joint Section of Cerebrovascular Neurosurgery. American Journal of Neuroradiology: Volume 22, Number 7; August 2001; pages 1438-1439.

34. Higashida RT: Development of a pontine after endovascular coil occlusion of a basilar artery trunk aneurysm: case report. Commentary. Neurosurgery52:694-701. 2003.

35. Higashida RT: Neuroimaging Clinics of North America: Venous Disorders of the Central Nervous System. American Journal of Neuroradiology Book Review. AJNR. 24:10; 2119. 2003.

36. Higashida RT: Thrombolysis In Acute Ischemic Stroke: Intra-Arterial and Intra-Venous. Interventional Neuroradiology 9 (Suppl 2): 39-40, 2003.

37. Higashida RT: Intracranial Stenting: Which Patients and When?". Cleveland Clinic Journal of Medicine. Volume 70, Supplement 6, December 2003, S2-S3.

38. Cullen S, Higashida RT: Editorial Commentary: Preliminary experience using the neuroform stent for the treatment of cerebral aneurysms. Neurosurgery. Volume 54, Number 1, January 2004. Page 17.

39. Higashida RT: Editorial Commentary: Age-dependent differences in short-term outcome after surgical or endovascular treatment of unruptured intracranial aneurysms in the United States, 1996-2000. Neurosurgery. Volume 54, Number 1, January 2004. Page 29.

40. Higashida RT: Intracranial Stenting: Which patients and when? Cleveland Clinic Journal of Medicine. Volume 71, Supplement 1, January 2004. Page S50-51.

41. Cullen S, Higashida RT: Editorial Commentary: Clinical Trials in Cerebrovascular Diseases. Neurosurgery. Volume 54, 2; 266. 2004.

42. Cullen S, Higashida RT: Editorial Commentary: Endovascular Aneurysm Treatment. Neurosurgery. Volume 54, 2, 284-285. 2004.

43. Higashida RT: Interventional Treatment for Acute Ischemic Stroke. Stroke Rounds. Volume 2, Issue 2. 2004

44. Higashida RT: Re-occlusion after intra-arterial thrombolysis for acute stroke. Journal Watch: Neurology. Massachusetts Medical Society. July 2004, Volume 6, Number 7.

45. Higashida RT: Training and Credentialing for Cervicocerebral Imaging and Carotid Stenting. Journal Watch. Neurology. Massachusetts Medical Society. April 2005, Vol 7, No. 4.

46. Higashida RT: Commentary on Y-Configured dural intracranial stent-assisted coil embolization for the treatment of wide-necked basilar tip aneurysms. Neurosurgery, Vol 56, No. 5, May 2005, pgs 1039-1040.

47. Higashida RT: Interventional Neuroradiology: A Less Invasive Approach For The Treatment Of Complex Cerebrovascular Diseases & Stroke. San Francisco Medicine. March/April 2006. Volume 79; 2; 26-18.

140 of 193 Prepared: October 27, 2015

48. Meyers PM, Phatouros CC, Higashida RT: Hyperperfusion syndrome after intracranial angioplasty and stent placement. Stroke 2006; 37:2210-2011.

49. Saloner D, Marin AJ, Rayz V, Acevedo-Bolton G, Boussel L, Lawton MT, Young WL, Higashida RT: Imaging the progression of aneurysmal disease. Images. UCSF Radiology Magazine. Pages 17-19, 2007.

50. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, MarrA, Roux S, Kassell N: Response Letter to the CONSCIOUS-2 Study. The Lancet. Neurology D-11-00512R1. 2011

51. Meyers PM, Higashida RT, McDougall C, Hussain MS, Hirsch JA: Commentary: Does physician specialty matter. Journal of Neurosurgery. 2015. 14-1030.

PATENTS ISSUED OR PENDING (ALLOWED)

1. US Patent Application No: 2003/0191,493: A Device For Clot Retrieval and Distal Protection

Filed: April 5, 2002

Published: October 9, 2003

Serial #: 10/118,30 ABAN

A device for retrieving clot material and distal protection within a having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member having proximal and distal extremities is carried by the distal extremity of the elongated tubular member and is movable between radially contracted and expanded configurations. A deformable membrane at least partially covers the expansile member in the radially expanded configuration. A guide member is coupled to the distal extremity of the expansile member and has proximal and distal ends. A handle assembly is carried by the proximal extremity of the elongated tubular member for moving said expansile member between radially contracted and expanded configurations. The handle assembly is detachable from the proximal extremity of the elongated tubular member.

First Claim

141 of 193 Prepared: October 27, 2015

1. A device for distal protection within a blood vessel having a wall defining a lumen in the body comprising an elongated tubular member having proximal and distal extremities and having a longitudinal axis, an expansile member having proximal and distal extremities, the expansile member being carried by the distal extremity of the elongated tubular member and movable between radially contracted and expanded configurations, a deformable membrane at least partially covering the expansile member in the radially expanded configuration, a guide member coupled to the distal extremity of the expansile member, said guide member having proximal and distal ends and a handle assembly carried by the proximal extremity of the elongated tubular member for moving said expansile member between radially contracted and expanded configurations, said handle assembly being detachable from the proximal extremity of the elongated tubular member.

ABSTRACTS

1.

SCIENTIFIC EXHIBITS

2.

International Scientific Exhibits

3. "Interventional Neuroradiology: Applications and techniques in neurovascular procedures", Higashida RT, Hieshima GB, Halbach VV. Japanese Congress of Neurosurgery, Nagoya, Japan, December 1985.

4. "Real time digital subtraction angiography: Use in interventional neuroradiology", Higashida RT, Hieshima GB, Halbach VV, Reicher MA, Goto K, XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 1986.

5. "Intravascular balloon embolization therapy for intracranial aneurysms: Technique", Halbach VV, Hieshima GB, Higashida RT, Goto K, Dormandy B. XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 1986.

6. "Intravascular embolization of carotid cavernous sinus fistulae: Indications and techniques", Higashida RT, Hieshima GB, Halbach VV, Bentson JR, XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 1986.

142 of 193 Prepared: October 27, 2015

7. "Treatment of intracranial aneurysms by interventional neuroradiological techniques", Higashida RT, Hieshima GB, Halbach VV, Norman D, Newton TH, The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

8. "Intravascular embolization of carotid cavernous sinus fistulae: Therapeutic results in 138 cases", Higashida RT, Hieshima GB, Halbach VV, Norman D, Newton TH, The 5th Asian- Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

9. "Real time digital subtraction angiography: Applications in intraoperative and interventional neurovascular procedures", Higashida RT, Hieshima GB, Halbach VV, Norman D, Newton TH, The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, September 21 - 25, 1987.

10. "Treatment of surgically inaccessible cavernous carotid artery aneurysms by detachable balloon embolization techniques", Higashida RT, Halbach VV, Hieshima GB, Dowd CF, Barnwell SL, 17th International Congress of Radiology, Paris, France, July, 1989.

11. "Percutaneous transluminal angioplasty of the subclavian, vertebral, and basilar arteries", Higashida RT, Halbach V, Hieshima GB, Barnwell SL, Dowd C, 17th International Congress of Radiology, Paris, France, July, 1989.

12. "Treatment of traumatic carotid and vertebral artery lesions by interventional neurovascular techniques: Therapeutic results in 234 cases", Higashida RT, Halbach VV, Hieshima GB, Dowd CF, Barnwell SL, 17th International Congress of Radiology, Paris, France, July, 1989.

13. "Percutaneous transluminal angioplasty of the subclavian, vertebral, and basilar arteries". Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: 14th International Symposium Neuroradiologicum. London, England. June 1990.

14. "Particulate embolization of the anterior choroidal artery". Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB. 14th International Symposium Neuroradiologicum. London, England. June 1990.

15. "Treatment of dural arteriovenous fistulas involving the transverse and sigmoid sinuses by transvenous embolization: Results in 20 patients". Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. 14th International Symposium Neuroradiologicum. London, England. June 1990.

16. "Petrous carotid aneurysms treated by endovascular techniques." Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL. 14th International Symposium Neuroradiologicum. London, England. June 1990.

17. "Transluminal angioplasty of symptomatic intracranial arterial vasospasm". Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: 14th International Symposium Neuroradiologicum. London, England. June 1990.

18. "Recombinant Pro-Urokinase (Prolyse) for Acute Cerebral Thromboembolism. del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS. 20th International Joint Conference on Stroke and Cerebral Circulation. February 9-11, 1995. Charleston, South Carolina.

19. "PROACT and the clinical trials acceleration program: Further lessons about acute stroke care in North America". (Higashida RT, collaborator) 21st International Joint Conference on

143 of 193 Prepared: October 27, 2015

Stroke and Cerebral Circulation. American Heart Association Annual Scientific Meeting. January 25-27, 1996. San Antonio, Texas.

20. "Proact II: Recombinant Prourokinases (r-ProUK) in Acute Cerebral Thromboembolism. Furlan A, Higashida RT, Wechsler, Schulz G. American Heart Association. 23rd International Joint Conference on Stroke and Cerebral Circulation. February 507, 1998. Orlando, Florida.

21. "De Novo dural arteriovenous fistulae caused by cerebral sinus thrombosis." Johnston SC, Smith WS, Dowd CF, Higashida RT, Lawton MT. The 3rd Annual Meeting of the Joint Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. Orlando, Florida. February 1-4, 1998.

22. "Angioplasty in symptomatic vertebrobasilar ischemia." Gress Dr, Finley R, Smith WS, Higashida RT. American Heart Association 23rd International Joint Conference on Stroke and Cerebral Circulation. Orlando, Florida. February 5-7, 1998.

23. "Proact II Trial Results: Clinical Benefit of Intra-Arterial Recombinant Prourokinase in Acute Middle Cerebral Artery Stroke. Rowley HA, Furlan AJ, Higashida RT, Wechsler L, Kase C, Dillon WP, Fischbein N, Roberts HC, Gent M. Annual Meeting of the European Society of Neuroradiology. Vienna, Austria. September 7-10, 1999.

24. "The Proact III Trial: Intra-Arterial Thrombolysis in Acute Ischemic Stroke". The Proact 3 Executive Committee and Abbott Laboratories. (Higashida RT, collaborator)The 4th International Conference on Acute Ischemic Stroke. November 25-30, 2000. Melbourne, Australia.

25. "The MERCI Concentric Clot Retrieval Study: Interim Analysis". MERCI Clinical Trial Group. (Higashida RT, collaborator) American Heart Association Scientific Annual Meeting. February 12-16, 2003. Phoenix, Arizona.

26. Multi MERCI: A Multinational registry to Evaluate the concentric MERCI Retriever System. MERCI Clinical Trial Group. (Higashida RT, collaborator) 29th International Stroke Conference. American Stroke Association. February 5-7, 2004. San Diego, California.

27. Dynamic Susceptibility-Weighted Contrast-Enhanced MR Imaging of Meningioma's Before and After Transarterial Embolization". Cha S, Martin Al, Hoghooghi D, Weber O, Chang J, Dillon W, Higashida RT, Saloner D. International Symposium Magnetic Resonance Imaging. 13th Annual Scientific Meeting. Miami Beach, Florida. May 10-14, 2005.

28. Meningioma Embolization Assessment with Interventional Magnetic Resonance Imaging. Martin A, Cha S, Dillon W, Higashida RT, Dowd CF, Halbach VV. Annual Scientific Meeting of the International Society of Magnetic Resonance Imaging. Seattle, Washington. May 7-10, 2006.

29. CONSCIOUS-2: Clazosentan to Overcome Neurological Ischemia and Infarction Occurring after Aneurysmal Subarachnoid Hemorrhage. Keller E, Higashida RT, Macdonald RL, Mayer S, Raabe, Kassell N. European Society of Neurological Surgery Annual Meeting. June 2008.

30. Predictors of favorable neurologic outcome 6 months after subarachnoid hemorrhage. Ko NU, Higashida RT, Lawton MT, Johnston SC, Smith WS. American Stroke Association. San Diego, California. February 2009.

144 of 193 Prepared: October 27, 2015

31. Shi ZS, Duckwiler G, For the MERCI and Multi MERCI Investigators. (Higashida RT, collaborator) Comparison of Revascularization and Outcomes of Mechanical Thrombectomy in Failed Intravenous tPA to Non-Intravenous tPA Patients Stratified by Site of Arterial Occlusion. Slide presentation at ISC 2009 & Poster.

32. Intracranial hemorrhage and its relationship to reperfusion and clinical outcome. An exploratory analysis of the Proact II Trial. (Higashida RT, collaborator) International Stroke Conference. San Antonio Texas. February 24-26, 2010.

33. Effect of clazosentan on clinical outcome after aneurysmal subarachnoic hemorrhage and endovascuylar coiling: Results of the Conscious-3 Study. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux AJ, Raabe A. International Stroke Conference. February 1-3, 2012.

34. "Strict Blood Pressure Control with Intravenous Nicardipine is Associated with Lower Risk of Acute Re-Bleeding after Aneurysmal Subarachnoid Hemorrhage". Shirani P, Fukuda K, Tieu L, Higashida RT, Lawton MT, Smith WS, Ko NU. International Stroke Conference. Annual Scientific Meeting. Honolulu, Hawaii. 2013.

36.

National Scientific Exhibits

37. "Digital vascular imaging using an isocon camera", Barbaric ZL, Higashida RT, Winters J, American Roentgen Ray Society, Annual Scientific Assembly, New Orleans, LA, May 1982.

38. Intrauterine membranes in the second trimester: Clinical significance", King W, Higashida RT, Radiological Society of North America, 69th Annual Scientific Assembly, Chicago, IL, November 1983.

39. "Coronal ultrasound of the neonatal abdomen", Higashida RT, Diament M, Boechat M, Kangarloo H, Radiological Society of North America, 69th Annual Scientific Assembly, Chicago, IL, November 1983.

40. "The non-filled bladder: Techniques and applications in assessment of the early second trimester pregnancy", Higashida RT, King W. Radiological Society of North America, 69th Annual Scientific Assembly, Chicago, IL November 1983.

41. "Intravascular embolization of carotid cavernous sinus fistulae: Indications, techniques and therapeutic results in 138 cases", Higashida RT, Hieshima GB, Bentson JR, American Society of Neuroradiology Meeting, New Orleans, LA, February 1985, (Cum Laude Award).

42. "Therapeutic embolization of carotid cavernous sinus fistulae", Higashida RT, Bentson JR, Hieshima GB, Radiological Society of North America 71st Annual Scientific Assembly, Chicago, IL, November 1985.

43. "Treatment of intracranial arterial vasospasm following subarachnoid hemorrhage by transluminal angioplasty", Higashida RT, Wapenski JA, Halbach VV, Hieshima GB, 39th Annual Meeting, American Academy of Neurology, New York, NY, April 5-11, 1987.

145 of 193 Prepared: October 27, 2015

44. "Embolization of carotid cavernous sinus fistulae", Higashida RT, Hieshima GB, Halbach VV, Wapenski JA. 39th Annual Meeting, American Academy of Neurology, New York, NY, April 5- 11, 1987.

45. "Therapeutic intravascular balloon embolization of intracranial aneurysms", Higashida RT, Wapenski JA, Hieshima GB, Halbach VV, 39th Annual Meeting, American Academy of Neurology, New York, NY, April 5-11, 1987.

46. "Intravascular embolization of carotid cavernous sinus fistulae: Indications, techniques, and therapeutic results in 138 cases", Higashida RT, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons Annual Meeting, Dallas, TX, May 3-6, 1987.

47. "Treatment of intracranial aneurysms by intravascular detachable balloon embolization", Higashida RT, Halbach VV, Hieshima GB. American Society of Neuroradiology. 25th Annual Meeting, New York, NY, May 10-15, 1987.

48. "Newer techniques for intravascular and intraoperative neurointerventional procedures", Higashida RT, Halbach VV, Hieshima GB, Yang P. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10-15, 1987.

49. "Treatment of surgically inaccessible cavernous carotid artery aneurysms by detachable balloon embolization techniques." Higashida RT, Halbach VV, Hieshima GB. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10-15, 1987.

50. "Normal perfusion breakthrough occurring during treatment of carotid and vertebral fistulas", Halbach VV, Higashida RT, Hieshima GB, Norman, D. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10-15, 1987.

51. "Newer techniques for intravascular neurointerventional procedures", Higashida RT, Halbach V, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

52. "Treatment of intracranial aneurysms by intravascular detachable balloon embolization techniques", Higashida RT, Halbach VV, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

53. "Transvenous embolization of dural fistulas involving the cavernous sinus", Halbach VV, Higashida RT, Hieshima GB, 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 1988.

54. "Superior ophthalmic vein approach in the treatment of carotid cavernous sinus fistulas" , Dowd C, Halbach VV, Barnwell S, Higashida RT, Hieshima GB, 27th Annual Meeting, American Society of Neuroradiology, Orlando, Florida, March 1989.

55. "Transarterial occlusion of solitary intracerebral arteriovenous connections", Halbach VV, Higashida RT, Dowd C, Barnwell S, Hieshima GB, 27th Annual Meeting, American Society of Neuroradiology, Orlando, Florida, March 1989.

56. "Dural arteriovenous fistulas supplied by ethmoidal arteries". Halbach VV, Higashida RT, Dowd C, Barnwell S, Hieshima GB, 28th Annual Meeting, American Society of Neuroradiology, Los Angeles, California, March 1990.

146 of 193 Prepared: October 27, 2015

57. "Aggravation of visual symptoms during treatment of carotid-cavernous fistulas from occlusion of the anterior (proximal) superior ophthalmic vein." Dowd C, Halbach VV, Higashida RT, Barnwell S, Hieshima GB, 28th Annual Meeting, American Society of Neuroradiology, Los Angeles, California, March 1990.

58. "Particulate embolization of the anterior choroidal artery." Dowd C, Halbach VV, Higashida RT, Barnwell S, Hieshima GB, 28th Annual Meeting, American Society of Neuroradiology, Los Angeles, California, March 1990.

59. "Interventional techniques for treatment of complex intracranial arterial aneurysms". Higashida RT, Hieshima GB, Halbach VV, Dowd CF, Barnwell. Congress of Neurological Surgeons. Practical course on endovascular techniques in Neurosurgery. Los Angeles, California. October 1990.

60. "PreOperative embolization in the treatment of hemangioblastoma." Baumgartner JE, Dowd CF, Hieshima GB, Halbach VV, Higashida RT. Sixtieth Annual Scientific Meeting of the American Association of Neurological Surgeons. San Francisco, California. April 1992.

61. "Dural arteriovenous fistulas involving the superior petrosal sinus: Endovascular and Surgical Therapy." Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Wilson CB, Hieshima GB. Sixtieth Annual Scientific Meeting of the American Association of Neurological Surgeons. San Francisco, California. April 1992.

62. "Endovascular approaches to treatment of cerebral aneurysms." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Congress of Neurological Surgeons. Practical Course for Neurosurgery. Washington, D.C. November 1-5, 1992.

63. "Interventional treatment of cerebral AVM's". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Congress of Neurological Surgeons. Practical Course for Neurosurgery. Washington, D.C. November 1-5, 1992.

64. "Dural arteriovenous fistulas of the Vein of Galen: Endovascular and surgical therapy". Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Fraser KW, Smith TP, Teitelbaum GB, Terada T, Hieshima GB, Wilson CB. Sixty-first Annual Meeting of the American Association of Neurological Surgeons, Boston, Massachusetts, April 24-29, 1993.

65. "Cerebral percutaneous transluminal angioplasty." Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. American Society of Neuroradiology. Annual Scientific Meeting. Nashville, Tennessee. May 1-7, 1994.

66. "Endovascular management of acute traumatic vascular injuries to the head and Neck: Therapeutic Options." Higashida RT, McDougall C, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons. 63rd Annual Meeting. Orlando, Florida. April 22- 27, 1995.

67. "Percutaneous transluminal angioplasty of extra- and intracranial cerebrovascular disease." Higashida RT, McDougall C, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons. 63rd Annual Meeting. Orlando, Florida. April 22-27, 1995.

68. "Balloon angioplasty for cerebral vasospasm following subarachnoid hemorrhage." Bonavitch D, Gress D, Halbach VV, Dowd CF, Higashida RT, Smith W. Annual Meeting of the American Association of Neurology. Minneapolis, Minnesota. April 27, 1998-April 30, 1998.

147 of 193 Prepared: October 27, 2015

69. "De novo dural arteriovenous fistulae caused by cerebral sinus thrombosis". Johnston SC, Smith WS, Dowd CF, Higashida RT, Lawton MT, Halbach VV, Bonovich DC, Gress DR. Annual Meeting of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. 1998

70. "Endovascular treatment of carotid cavernous sinus fistulas." Larson T, Higashida RT. The Second Annual Scientific Meeting of the Joint Section of Cerebrovascular Surgery and The American Association of Interventional and Therapeutic Neuroradiology. Nashville, Tennessee. February 1-3, 1999.

71. "Risks associated with treatment of unruptured aneurysms". Johnston SC, Wilson CB, Halbach VV, Higashida RT, Dowd CF, Lawton MT, Mc Dermott MW, Applebury CB, Farley TL, Gress DR. 24th Annual Meeting of the American Heart Association: Stroke Council. February 4-6, 1999. Nashville, Tennessee.

72. "Treatment of an intracranial aneurysm using a new three-dimensional shape Guglielmi Detachable Coil." Malek A, Higashida RT, Phatouros CC, Dowd CF, Halbach VV. Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. January 31, 1999 - February 3 ,1999. Nashville, Tennessee.

73. "Rescue treatment of acute parent vessel thrombosis with glycoprotein IIb/IIIa inhibitor during GDC coil embolization. Malek A, Lempert TE, Halbach VV, Malek AM, Phatouros CC, Higashida RT, Dowd CF. Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. January 31, 1999 - February 3 ,1999. Nashville, Tennessee.

74. "A comparison of endovascular vs. surgical treatment for unruptured cerebral aneurysms". Hopkins N, Higashida RT, Justason B. Annual Meeting of the Congress on Neurological Surgeons. September 2002. Philadelphia, Pennsylvania.

75. "The Diverter Filter Device for Treatment of Acute Thromboembolic Stroke". Higashida, RT, Oz O: Innovation and Research in Interventional Radiology Meeting: Stroke Interventions. January 30-31, 2004, Bethesda, Maryland.

76. "The Concentric Merci Retriever Study: Results of the Phase I Trial". Higashida RT, Duckwiler G, and the Merci Study Investigators. Innovation and Research in Interventional Radiology Meeting: Stroke Interventions. January 30-31, 2004, Bethesda, Maryland.

77. Endovascular Stenting of Vertebro-Basilar Artery Stenosis: Complications and Long Term Follow Up. Higashida RT, Halbach VV, Dowd CF, Gress D. Neurocritical Care Society. Annual Meeting. February 6-8, 2004. San Diego, California.

78. "Management of acute subarachnoid hemorrhage at UCSF Medical Center." Ko N, Lawton ML, Higashida RT, Smith WS. Annual Meeting of the American Association of Neurology. April 2005.

79. Duckwiler G for the MERCI and Multi MERCI Investigators Outcomes in M1 Versus Isolated M2 Strokes in Multi MERCI. (Higashida, RT, collaborator) ASITN 4th Annual Meeting, July 30-August 3, 2007 - Poster, Honolulu, Hawaii.

148 of 193

Prepared: October 27, 2015

93. "Magnetic resonance imaging of the orbital apices, cavernous sinuses and related cranial ", Bentson JR, Rauschning W, Hieshima GB, Lufkin R, Higashida RT, Wilson G. XVI International Congress of Radiology, Annual Scientific Assembly, Hawaii, July 1985.

94. "Digital for the treatment of intracranial aneurysms with detachable balloon." Goto K, Hieshima GB, Halbach VV, Reicher MA, Higashida RT, Bentson JR. Japanese Congress of Neurosurgery, Nagoya, Japan, December 1985.

95. "Interventional neuroradiological procedures for treatment of aneurysms and arteriovenous malformations." Hieshima GB, Higashida RT, Halbach VV. Japanese Congress of Neurosurgery, Nagoya, Japan, December 1985.

96. "Transluminal angioplasty of the subclavian and vertebral arteries for vertebral basilar insufficiency", Higashida RT, Hieshima GB, Tsai FY, Halbach VV, Bentson JR. XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 23-28, 1986.

97. "Intravascular balloon embolization therapy for aneurysms", Higashida RT, Hieshima GB, Wapenski JA, Halbach VV, Cahan L, Goto K. XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 23-29, 1986.

98. "Treatment of cervical carotid artery aneurysms and pseudoaneurysms", Higashida RT, Hieshima GB, Wapenski JA, Halbach VV, Cahan L, Goto K. XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 23-28, 1986.

99. "The feasibility of percutaneous transluminal angioplasty for the treatment of carotid artery stenosis", Tsai FY, Matovich VB, Hieshima GB, Shah DC, Tiu GY, Higashida RT, Pribram HFW. XIII Symposium Neuroradiologicum Stockholm, Sweden, June 23-28, 1986.

100. "Treatment of direct carotid cavernous sinus fistulae: Various therapeutic approaches and results in 148 cases", Goto K, Hieshima GB, Higashida RT, Halbach VV, Bentson JR, Mehringer M, Pribram HF. XIII Symposium Neuroradiologicum, Stockholm, Sweden, June 23-28, 1986.

101. "Treatment of intracranial aneurysms presenting with mass effect: Results in 66 patients". Halbach VV, Hieshima GB, Higashida RT. 7th Annual Meeting of the Working Group in Interventional Neuroradiology, Val d'Isere, France, January 19-24, 1987.

102. "Treatment of intracranial aneurysms with hemorrhage", Hieshima GB, Halbach VV, Higashida RT. 7th Annual Meeting of the Working Group in Interventional Neuroradiology, Val d'Isere, France, January 19-24, 1987.

103. "Transvascular balloon angioplasty of cerebral vasospasm", Hieshima GB, Halbach VV, Higashida RT. 7th Annual Meeting of the Working Group in Interventional Neuroradiology, Val d'Isere, France, January 19-24, 1987.

104. "Treatment of dural fistulae and carotid cavernous fistulae", Halbach VV, Higashida RT, Hieshima GB. International Symposium on Surgery for Cerebral Stroke, Sendai, Japan, May 24- 27, 1987.

105. "Transluminal angioplasty of cerebral vasospasm", Halbach VV, Higashida RT, Hieshima GB. International Symposium on Surgery for Cerebral Stroke, Sendai, Japan, May 24-27, 1987.

150 of 193 Prepared: October 27, 2015

106. "Nonsurgical treatment of arteriovenous malformations", Halbach VV, Higashida RT, Hieshima GB. International Symposium on Surgery for Cerebral Stroke, Sendai, Japan, May 24- 27, 1987.

107. "Intravascular embolization of direct carotid cavernous sinus fistulae: Therapeutic results in 122 cases", Higashida RT, Hieshima GB, Halbach VV, Norman D, Newton TH. The 5th Asian- Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

108. "Treatment of surgically inaccessible cavernous carotid artery aneurysms by detachable balloon embolization techniques", Higashida RT, Hieshima GB, Halbach VV. The 5th Asian- Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

109. "Current status of interventional neuroradiology", Hieshima GB, Higashida RT, Halbach VV. The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

110. "Detachable balloon occlusion of aneurysms", Hieshima GB, Higashida RT, Halbach VV. The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

111. "Percutaneous transluminal angioplasty of the subclavian, vertebral and basilar arteries", Higashida RT, Hieshima GB, Halbach VV, Norman D, Newton TH. The 5th Asian-Oceanian Congress of Radiology, Seoul, Korea, September 21-25, 1987.

112. "HEMA - A polymer for detachable balloons", Goto K, Halbach VV, Higashida RT, Hieshima GB. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

113. "Transvenous embolization of dural fistulas involving the cavernous sinus". Halbach VV, Higashida RT, Hieshima GB. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

114. "Treatment of difficult aneurysms by transvascular balloon embolization". Halbach VV, Higashida RT, Hieshima GB. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

115. "Transvenous embolization of dural fistulas involving the transverse and sigmoid sinuses". Halbach VV, Higashida RT, Hieshima GB. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

116. "Pre-operative balloon embolization of arteriovenous malformations", Halbach VV, Higashida RT, Hieshima GB, Hardin CW. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

117. "Transvenous embolization of direct carotid cavernous fistulas", Halbach VV, Higashida RT, Hieshima GB. 8th Annual Meeting, Working Group in Interventional Neuroradiology. Val d'Isere, France, January 1988.

118. "Carotid cavernous fistulae: Unusual clinical presentations", Numaguchi Y, Hieshima GB, Higashida RT. The 17th Annual Meeting, Japan Neuroradiology Conference, Japan, February 19-20, 1988.

151 of 193 Prepared: October 27, 2015

119. "Balloon angioplasty of intracranial arterial vasospasm", Higashida RT, Halbach VV, Hieshima GB. British Society of Neuroradiology and Neurosurgery, Annual Meeting, Glasgow, Scotland, September 1988.

120. "Angioplasty of brachiocephalic vessels for atherosclerotic disease", Higashida RT, Halbach VV, Hieshima GB. British Society of Neuroradiology and Neurosurgery. Annual Meeting. Glasgow, Scotland. September 1988.

121. "The anterior superior ophthalmic vein approach in the treatment of dural carotid cavernous fistulas", Dowd C, Halbach V, Higashida RT, Barnwell S, Hieshima GB, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

122. "Endovascular treatment of solitary arteriovenous fistulas by platinum coils", Kwan E, Halbach V, Higashida RT, Hieshima GB, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

123. "Mixture of HEMA and non ionic contrast in silicone microballoons: Osmotic effects", Hardin CW, Hieshima GB, Halbach VV, Higashida RT, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

124. "Transvenous treatment of Vein of Galen aneurysms", Dowd CF, Halbach V, Higashida RT, Hieshima GB, Barnwell SL, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

125. "Transvenous embolization of perimedullary spinal fistulas" Dowd CF, Halbach V, Higashida RT, Hieshima GB, Barnwell S. Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

126. "Aggravation of symptoms produced by occlusion of the superior ophthalmic vein", Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Barnwell SL, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

127. "A new approach to the treatment of direct carotid cavernous fistulas: Platinum coils", Halbach VV, Higashida RT, Hieshima GB, Dowd C. Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

128. "Transvenous embolization of dural fistulas involving the deep cerebral venous system", Halbach V, Higashida RT, Hieshima GB, Dowd C, Working Group in Interventional Neuroradiology, 9th Annual Meeting, Val d' Isere, France, January 1989.

129. "Direct puncture of the distal internal carotid artery for the treatment of carotid cavernous sinus fistulas with proximal occlusion", Halbach V, Higashida RT, Hieshima GB, Dowd C. Working Group in Interventional Neuroradiology, 9 h Annual Meeting, Val d' Isere, France, January 1989.

130. "Endovascular treatment of cerebral vascular disease", Higashida RT, Halbach VV, Dormandy B, Bell J, Hieshima GB. 17th International Congress of Radiology, Paris, France, July 1989.

131. "Management of vascular perforations occurring during endovascular procedures", Halbach VV, Higashida RT, Barnwell SL, Dowd CF, Hieshima GB: 10th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1990.

152 of 193 Prepared: October 27, 2015

132. "Endovascular coil embolization of intracranial aneurysms", Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB: 10 h Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1990.

133. "Aggravation of visual symptoms during treatment of carotid cavernous fistulas from occlusion of the anterior (proximal) superior ophthalmic vein. Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB. 14th International Symposium Neuroradiologicum. London, England. June 1990.

134. "Vascular perforations resulting from neurointerventional procedures". Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. 14th International Symposium Neuroradiologicum. London, England. June 1990.

135. "Interventional neurovascular treatment of surgically inaccessible cavernous carotid artery aneurysms. Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: 14 h International Symposium Neuroradiologicum. London, England. June 1990.

136. "Intravascular detachable balloon embolization therapy of intracranial aneurysms with preservation of the parent vessel". Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB: 14th International Symposium Neuroradiologicum. London, England. June 1990.

137. "Interventional treatment of giant intracranial aneurysms". Hieshima GB, Higashida RT, Halbach VV. Tenth International Symposium on Microvascular Surgery for Cerebral Ischemia. San Francisco, California. July 1990.

138. "Transluminal angioplasty for cerebrovascular disease. Therapeutic Advances." Higashida RT, Halbach VV, Hieshima GB. Tenth International Symposium on Microvascular Surgery for Cerebral Ischemia. San Francisco, California. July 1990.

139. "Thrombolysis for Dural Sinus Thrombosis. Barnwell SL, Higashida RT, Dowd CF, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

140. "Treatment of partially thrombosed intracranial aneurysms". Barnwell SL, Higashida RT, Dowd CF, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

141. "A data base system for recording neurointerventional procedures." Barnwell SL, Higashida RT, Dowd CF, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

142. "Embolization of the anterior choroidal artery in arteriovenous malformations." Dowd CF, Barnwell SL, Higashida RT, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

143. "Combined endovascular and surgical treatment of giant intracranial aneurysms." Dowd CF, Barnwell SL, Higashida RT, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

144. "Transfemoral venous embolization of cerebral arteriovenous fistulas in children". Dowd CF, Barnwell SL, Higashida RT, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

153 of 193 Prepared: October 27, 2015

145. "Complications of endovascular balloon occlusion in the treatment of traumatic carotid pseudoaneuryms presenting with epistaxis." Dowd CF, Barnwell SL, Higashida RT, Halbach VV, Hieshima GB. 11th Annual Meeting of the Working Group in Interventional Neuroradiology, Val D' Isere, France, January 1991.

146. "Complications resulting from treatment of intracranial arteriovenous malformations". Higashida RT, Halbach VV, Hieshima GB, Dowd CF. Fourth Annual Meeting on Complications in NeuroInterventional Radiological Procedures. Jackson Hole, Wyoming. August 1-3, 1991.

147. "Complications resulting from endovascular treatment of intracranial arterial aneurysms". Higashida RT, Halbach VV, Hieshima GB, Dowd CF. Fourth Annual Meeting on Complications in NeuroInterventional Radiological Procedures. Jackson Hole, Wyoming. August 1-3, 1991.

148. "Intravascular transluminal angioplasty for acute vasospasm following subarachnoid hemorrhage." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. The twenty-first Annual International Conference on Surgery for Cerebral Stroke. March 3-4, 1992. Nagoya, Japan.

149. "Percutaneous transluminal angioplasty of acute carotid artery dissection." Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB. The twenty-first Annual International Conference on Surgery for Cerebral Stroke. March 3-4, 1992. Nagoya, Japan.

150. "Acute thrombolysis for intracranial thrombosis." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. The twenty-first Annual International Conference on Surgery for Cerebral Stroke. March 3-4, 1992. Nagoya, Japan.

151. "Endovascular treatment of giant anterior circulation intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB. The twenty-first Annual International Conference on Surgery for Cerebral Stroke. March 3-4, 1992. Nagoya, Japan.

152. "Treatment of giant posterior circulation intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. The twenty-first Annual International Conference on Surgery for Cerebral Stroke. March 3-4, 1992. Nagoya, Japan.

153. "Treatment of dural arteriovenous fistulas." Dowd CF, Halbach VV, Higashida RT, Smith TP, Fraser KW, Hieshima GB. International Conference on New Trends in the Management of Cerebral Vascular Malformations. June 8-12, 1992. Verona, Italy.

154. "Angioplasty of cerebral vasospasm." Dowd CF, Higashida RT, Halbach VV, Fraser KW, Smith TP, Hieshima GB. International Conference on New Trends in the Management of Cerebro-Vascular Malformations. June 8-12, 1992. Verona, Italy.

155. "Endovascular treatment of standard and giant aneurysms." Dowd CF, Higashida RT, Halbach VV, Fraser KW, Smith TP, Hieshima GB. International Conference on New Trends in the Management of Cerebro-Vascular Malformations. June 8-12, 1992. Verona, Italy.

156. "Endovascular management of vein of Galen malformations." Dowd CF, Higashida RT, Halbach VV, Fraser KW, Smith TP, Hieshima GB. International Conference on New Trends in the Management of Cerebro-Vascular Malformations. June 8-12, 1992. Verona, Italy.

154 of 193 Prepared: October 27, 2015

157. "Interventional treatment of arterial vasospasm by transluminal angioplasty." Scandinavian Neurosurgical Society. Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB. June 10-13, 1992. Tampare, Finland.

158. "Percutaneous transluminal angioplasty for brachiocephalic atherosclerosis. Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB. Scandinavian Neurosurgical Society. June 10-13, 1992. Tampare, Finland.

159. "Approaches to the Basilar and Vertebral arteries by interventional therapy." Higashida RT, Halbach VV, Dowd CF, Smith T, Fraser K, Hieshima GB. First International Skull Base Congress. June 14-20, 1992. Hannover, Germany.

160. "PreOperative evaluation of skull base tumors: The role of the neuroangiographer." Dowd CF, Halbach VV, Higashida RT, Fraser KW, Smith TP, Teitelbaum GP, Hieshima GB. Third International Conference on Head and Neck Cancer, San Francisco, California. June 26-30, 1992.

161. "PTA for arteriosclerotic lesions of the basilar and distal vertebral arteries." Terada T, Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Annual Meeting of the Japanese Congress Neurosurgical Society. Tokyo, Japan. September 1993.

162. "Angioplasty for intracranial arterial vasospasm from subarachnoid hemorrhage". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The IVth International Symposium of Interventional Neuroradiology. Mexico City, Mexico. October 15-17, 1993.

163. Cerebral transluminal angioplasty for atherosclerotic disease." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The IVth International Symposium of Interventional Neuroradiology. Mexico City, Mexico. October 15-17, 1993.

164. "Endovascular treatment of traumatic vascular injuries". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The IVth International Symposium of Interventional Neuroradiology. Mexico City, Mexico. October 15-17, 1993.

165. "Transluminal Angioplasty of Head and Neck Lesions." Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB. International Congress VII: Endovascular Interventions. Scottsdale, Arizona. February 13-17, 1994.

166. "Percutaneous transluminal angioplasty for intracranial vertebro-basilar artery lesions." Terada T, Higashida RT, Halbach VV, Dowd CF, Hieshima GB, Kinoshita Y, Yokote H, Nakai E, Itakura T, Komai N. Fifth International Symposium on Interventional Radiology and Vascular Imaging. May 22-25, 1994. Wakayama, Japan.

167. "Interventional neuroradiological techniques for acute stroke therapy management." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Third International Meeting of Thrombolytic Therapy in Stroke. April 1-2, 1994. Nara, Japan.

168. "Transluminal angioplasty for extracranial and intracranial cerebral vascular disease". Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. The XV International Radiologicum Symposium. Kumamoto, Japan. September 25-October 1, 1994.

155 of 193 Prepared: October 27, 2015

169. "Interventional neurovascular treatment of giant intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D. The XV International Radiologicum Symposium. Kumamoto, Japan. September 25-October 1, 1994.

170. "Endovascular neurosurgery for treatment of surgically difficult intracranial aneurysms". Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D, Hieshima GB: Endovascular Neurosurgical Society of Japan. Scientific Session, Niigata, Japan. November 24-25, 1994.

171. "Complications resulting from endovascular surgical treatment of intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D, Hieshima GB: Endovascular Neurosurgical Society of Japan. Scientific Session, Niigata, Japan. November 24-25, 1994.

172. "Treatment of Cerebral AVM's by endovascular techniques." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Second International Congress on Minimally Invasive Therapy in Neurosurgery. Pittsburgh, Pennsylvania. June 17-20, 1995.

173. "Interventional endovascular treatment of cerebral AVM's." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Asian Oceanian Congress of Neurosurgery. International Scientific Meeting. Taipei, Taiwan. November 6-10, 1995.

174. "Giant Aneurysms: Technical considerations in intervention." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The International Congress on Interventional Neuroradiology and Intravascular Surgery. November 19-22, 1995. Kyoto, Japan.

175. "Evaluation of acute thrombogenesis of microcoil for treatment of experimental aneurysms." Konishi Y, Halbach VV, Higashida RT, Larsen D, McDougall C, Dowd C, Hieshima GB. . The International Congress on Interventional Neuroradiology and Intravascular Surgery. November 19-22, 1995. Kyoto, Japan.

176. "Transluminal angioplasty, thrombolysis, and stenting for extracranial and intracranial cerebral vascular disease." Higashida RT, Halbach VV, Tsai FY, Dowd CF, Hieshima GB. The International Congress on Interventional Neuroradiology and Intravascular Surgery. November 19-22, 1995. Kyoto, Japan.

177. "The Prolyse for Acute Cerebral Thromboembolism Trial". Higashida RT, Furlan A, Wechsler L. 21st International Joint Conference on Stroke and Cerebral Circulation. American Heart Association Annual Scientific Meeting. January 25-27, 1996. San Antonio, Texas.

178. "The Prolyse in Acute Cerebral Thromboembolism Trial (PROACT): Results of the 6 mg Dose Tier. Furlan T, del Zoppo G, Higashida RT, Pessin M. 4th International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke. Copenhagen, Denmark. May 30-June 1, 1996.

179. "Interventional therapy for facial vascular malformations." Dowd CF, Halbach VV, Higashida RT. The World Federation of Interventional and Therapeutic Neuroradiology Scientific Session. September 12-17, 1997. New York, New York.

180. "Endovascular treatment of mural type vein of Galen malformations." Halbach VV, Dowd CF, Higashida RT, Balousek PA, Ciricillo SF. The 3rd Annual Meeting of the Joint Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. Orlando, Florida. February 1-4, 1998.

156 of 193 Prepared: October 27, 2015

181. "PTA assisted stenting for extracranial vascular disease." Tsai FY, Koenigsberg RA, Eckland Khillon G, Roth T, McCormick D, Higashida RT, Wang AM. The 3rd Annual Meeting of the Joint Section on Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. Orlando, Florida. February 1-4, 1998.

182. "Proact II: Recombinant prourokinase (r-proUK): Acute cerebral Thromboembolism. Initial trial results". Furlan RT, Higashida RT, Wechsler L, and the Proact II Investigators. 24th Annual Meeting of the American Heart Association: Stroke Meeting. February 3-6, 1999. Nashville, Tennessee.

183. "Complications of Intra-Arterial Cerebral Thrombolysis". Higashida RT. Global Revascularization Complications Meeting. Jackson, Wyoming. June 23-26, 1999.

184. "CT Finding in Intra Arterial Thrombolysis in the ProACT II Trial". Roberts H, Furlan T, Higashida RT, Wechsler L, and the Proact II Investigators. 25th Annual Meeting of the American Heart Association: Stroke Meeting. February 9-12, 2000. New Orleans, Louisiana.

185. "Factors influencing outcome and treatment effect in PROACT II". Wechsler L, Robert R, Furlan A, Higashida RT, Dillon W, Roberts H, and the Proact Investigators. 26th International Stroke Conference. February 14-16, 2001, Fort Lauderdale, Florida.

186. "Angiographic collaterals in acute stroke: Relationship to clinical presentation and outcome: The PROACT II Trial. Roberts HC, Dillon WP, Furlan AJ, Rowley HA, Fischbein NJ, Higashida RT, and the Proact Investigators. 26th International Stroke Conference. February 14-16, 2001, Fort Lauderdale, Florida.

187. "Management of Pediatric AVMs". Higashida RT. International Meeting of the Cerebrovascular Neurosurgical Society and the American Society of Interventional and Therapeutic Neuroradiology. February 8-12, 2001. Waikiki, Hawaii.

188. "Intracranial Stenting for Symptomatic Atherosclerosis". Malek AM, Higashida RT, Dowd CF, Halbach VV. International Meeting of the Cerebrovascular Neurosurgical Society and the American Society of Interventional and Therapeutic Neuroradiology. February 8-12, 2001. Waikoloa, Hawaii.

189. "Extracranial Carotid Artery Stenting: Techniques and Results". Higashida RT. International Meeting of the Cerebrovascular Neurosurgical Society and the American Society of Interventional and Therapeutic Neuroradiology. February 8-12, 2001. Waikoloa, Hawaii.

190. "Erste Erfahrungen mit einem interventionellen X/MR- System. Weber O, Martin A, Roberts T, Higashida RT, Higgins". International Society of Magnetic Resonance Imaging in Medicine. Germany. September 1-5, 2001.

191. "Mechanical Embolus Removal in Cerebral Ischemia (MERCI) Trial". Higashida RT, Starkman, S, Gobin P. The 7th International Symposium on Thrombolysis and Acute Stroke Therapy. Lyon, France. May 27-28, 2002.

192. "Endovascular and surgical treatment for dural arteriovenous fistulae of the superior petrosal sinus". Halbach VV, Balousek P, Quinn R, Caragine LP, Dowd CF, Higashida RT. 17th Symposium Neuroradiologicum. Paris, France. May 17-24, 2002.

157 of 193 Prepared: October 27, 2015

193. "MERCI: A Safety Study of Embolectomy in Acute Ischemic Stroke". Gobin YP, Starkman S, Duckwiler G, Grobelny T, Pile-Spellman JP, Higashida RT, Marks M, Pryor J, Tong F, Kidwell C, Saver J. Annual Meeting of the Society of Radiology. March 30-April 3, 2003. Salt Lake City, Utah.

194. "Mechanical Thrombectomy in Acute Ischemic Stroke". Gobin YP, Starkman S, Duckwiler G, Grobelny T, Pile-Spellman JP, Higashida RT, Marks M, Pryor J, Tong F, Kidwell C, Saver J. Annual Meeting of the American Stroke Association. February 13-15, 2003. Phoenix, Arizona.

195. "Do Academic Training Programs Improve Treatment Outcomes for Patients with Unruptured Aneurysms?" Tobey MT, Justason BJ, Leip E, Hopkins LN, Higashida RT, Hanley D. Annual Meeting of the Joint Section of Cerebrovascular Neurosurgery and the American Society of Interventional and Therapeutic Neuroradiology. February 16-19, 2003. Phoenix, Arizona.

196. Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CA, Schulz G, Buchan AM. for the PROACT-II Investigators. Selection of Acute Ischaemic Stroke Patients for Intra-Arterial Thrombolysis with Prourokinase Using ASPECTS. Stroke 2003; 34: 246-247. Annual Meeting of the American Heart and Stroke Association. February 12-15, 2003. Phoenix, Arizona.

197. Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CA, Schulz G, Buchan AM. for the PROACT-II Investigators. . Selection of patients for intra-arterial thrombolysis using ASPECTS. Can J Neurol Sci 2002; 29: S6. Annual Meeting of the Canadian Congress of Neurological Surgeons Meeting. June 2002 Vancouver.

198. Caragine, LP, Higashida RT, Halbach VV, Dowd CF: The parallel venous channels as the recipient pouch in Transverse/Sigmoid Sinus Dural Fistulas. 29th International Stroke Conference. February 3-6, 2004. San Diego, California.

199. Starkman S, Merci Investigators: Results of the combined MERCI I-II (Mechanical Embolus Removal in Ce4rebral Ischemia) Trials. American Stroke Association, Annual Scientific Meeting. February 5-9, 2004. San Diego, California.

200. Duckwiler and the Merci Investigators: Results of the combined MERCI I/II (Mechanical Embolus Removal in Cerebral Ischemia Trials. (Higashida, RT, collaborator) Joint Section of Cerebrovascular Neurosurgery and American Society of Interventional and Therapeutic Neuroradiology. Annual Meeting. February 1-4, 2004. San Diego, California.

201. Martin A, Saloner D, Weber O, Roberts T, Roberts H, Dillon B, Halbach VV, Dowd CF, Higashida RT: MR Assessment of Carotid Stent Therapy. International Society of Magnetic Resonance Imaging. 12th Annual Scientific Meeting. Kyoto, Japan. May 17-20, 2004.

202. Ramey S, Higashida RT, for the Maveric Trial Investigators: The Results of the Maveric Carotid Artery Stent Trial. Annual Meeting of Tran catheter Therapeutics. Washington, DC. September 27-30, 2004.

203. Fullerton HJ, Achrol AS, Johnston C, McCulloch CE, Higashida RT, Lawton MT, Sidney S, Young WL: Intracranial hemorrhage rates in children vs. adults with brain arteriovenous malformations. American Stroke Association Annual Scientific Session. February 1-4, 2005. New Orleans, Louisiana.

158 of 193 Prepared: October 27, 2015

204. Ramee S, Higashida RT, on behalf of the MAVERiC Trial Investigators: Evaluation of the Medtronic Self Expanding Carotid Stent System with Distal Protection in the Treatment of Carotid Artery Stenosis: The MAVERiC Trial Phase II 30 Day Update. Transcatheter Therapeutics Annual Scientific Meeting. Washington DC. August 2004.

205. Higashida RT, Ramee S, and the Maveric Trial Investigators: The MAVERiC Trial Phase II Trial: An evaluation of the Medtronic Self Expanding Carotid Stent System to Treat Carotid Artery Stenosis. American Society of Interventional and Therapeutic Neuroradiology. Annual Scientific Meeting. August 1-5, 2005. Honolulu, Hawaii.

206. Higashida RT: Treatment of Intracranial Cerebral Aneurysms with Detachable Complex Platinum Coils. American Society of Interventional and Therapeutic Neuroradiology. Annual Scientific Meeting. August 1-5, 2005. Honolulu, Hawaii.

207. Higashida RT: Results of the MAVERIC Carotid Artery Stent Trial: 1 Year Follow Up. The Second Annual Meeting of the American Society of Interventional & Therapeutic Neuroradiology. Oahu, Hawaii. August 1-5, 2005.

208. Rayz VL, Martin AJ, Acevedo-Bolton G, Higashida RT, Lawton MT, Young WL, Saloner D: In vivo MR Velocimetry in intracranial aneurysms: Computational fluid dynamics specification and validation. International Society of Magnetic Resonance Annual Scientific Session. May 19- 25, 2007. Berlin, Germany.

209. Wade S, Higashida, RT, and the Merci Writing Group: Final Results of the Multi Merci Trial. International Stroke Conference. San Francisco, California. February 7-9, 2007.

210. Boussel L, Wintermark M, Dispensa B, Leach J, Rayz V, Acevedo-Bolton G, Lawton M, Higashida RT, Young W, Saloner D: MR Imaging for the determination of luminal and outer wall boundaries in intracranial aneurysms. The International Society of Magnetic Resonance Imaging. Berlin, Germany. May 2007.

211. Rayz V, Martin LL, Acevedo-Bolton G, Higashida RT, Lawton M, Young W, Saloner D: In vivo MR Velocimetry in Intracranial Aneurysms: Computational Fluid Dynamics Specification and Validation. The International Society of Magnetic Resonance Imaging. Berlin, Germany. May 2007.

212. Rayz V, Leach JR, Acevedo-Bolton G, Dispensa BP, Boussel L, Higashida RT, Wintermark M, Lawton M, Martin AJ, Young W, Saloner D: CE-MRA and Numerical Modeling of the Flow in Intracranial Aneurysms: Prediction of Regions Prone to Thrombus Formation. The International Society of Magnetic Resonance Imaging. Berlin, Germany. May 2007.

213. Saloner D, Rayz V, Leach JR, Dispensa BP, Boussel L, Acevedo-Bolton G, Higashida RT, Lawton M, Young W: CE-MRA and MR Velocimetry in the Determination of Hemodynamic Forces in Longitudinal Studies of Intracranial Aneurysm Growth. The International Society of Magnetic Resonance Imaging. Berlin, Germany. May 2007.

214. Acevedo-Bolton G, Rayz V, Martin AJ, Lawton M, Higashida RT, Young W, Saloner D: MR Determination of Flow Fields in Patient-Specific Models of Intracranial Aneurysms Using 7D PC- MRI. The International Society of Magnetic Resonance Imaging. Berlin, Germany. May 2007.

159 of 193 Prepared: October 27, 2015

215. Johnston C, Dowd CF, Halbach VV, Higashida RT: Predictors of Re-rupture after treatment of Ruptured Aneurysms: The CARAT Study. International Stroke Conference. February 7-9, 2006. San Francisco, California.

216. Patil C, Johnston C, McDougall C, Gress D, Piepgras DG, Duckwiler G, Higashida RT, et al: Predictors of Retreatment of Ruptured Intracranial Aneurysms: The Cerebral Aneurysm Rupture After Treatment Study. International Stroke Conference. 2008 Annual Scientific Meeting. New Orleans, Louisiana. February 2008.

217. Mayer S, Higashida, RT, for the Conscious 2 Trial: Conscious 2: Clazosentan to overcome Neurological Ischemia and Infarction Occurring in Subarachnoid Hemorrhage. 21st European Society of . Lisbon, Portugal. September 21-24, 2008.

218. Liebeskind DS, Hurst RW, Higashida, RT, for the MERCI™ Investigators Clinical Predictors of Angiographic Collaterals in Acute Ischemic Stroke. International Stroke Conference. 2005.

219. Liebeskind DS, Hurst RW, Higashida RT, for the MERCI™ Investigators Angiographic Collaterals and Outcome in Mechanical Thrombolysis. International Stroke Conference. Annual Scientific Session. 2005.

220. Liebeskind DS, Saver JL, Higashida, RT, for the MERCI™ Investigators Thiazide Diuretics are Associated with More Robust Collaterals in Acute Ischemic Stroke. International Stroke Conference. Annual Scientific Sessions. 2006.

221. Lutsep H, Nesbit G, Higashida, RT, for the MERCI™ Investigators Mechanical Thrombolysis for Stroke Due to Dissection in the MERCI Trials. International Stroke Conference. Annual Scientific Sessions. 2006.

222. Shi ZS, Duckwiler G, Higashida, RT, For the MERCI and MultiMERCI Investigators Clinical Outcomes in Middle Cerebral Artery Trunk Occlusions versus Secondary Division Occlusions after Mechanical Thrombectomy: Pooled Analysis of the MERCI and Multi MERCI Trials. International Stroke Conference. Annual Scientific Sessions. 2009.

223. Sung G, Sanossian N, Kim P, Liebeskind D, Higashida, RT, and Smith WS for the Merci and Multi-Merci Investigators The Utility of Immediate Post-Embolectomy Imaging. International Stroke Symposium. Scientific Sessions. 2009.

224. Sung G, Liebeskind D, Sanossian N, Nogueira R, Kim P, Smith WS, Higashida, RT, and Hemphill J.C. for the Merci and Multi-Merci Investigators Predicting Hemorrhagic Transformation After . International Stroke Conference. Scientific Sessions. 2009

225. Higashida RT, Furlan A, Wechsler L. Intracranial hemorrhage and its Relationship to Reperfusion and Clinical Outcome: An Exploratory Analysiss of the Proact II Trial. International Stroke Association Annual Meeting. New Orleans. La. February 2010.

226. Macdonald RL, Higashida RT, Keller E, Mayer SA, MOlyneus A, Raabe An, Vajkoczy P, Wanke I, Kassell NF: Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: Rationale and design of CONSCIOUS 2 and CONSCIOUS 3 Trials. Scientific Session of the Society of Neurocritical Care. October 2010.

160 of 193 Prepared: October 27, 2015

227. Salsberg J, Tomsick T, Carrozzella J, Martin RL, Furlan A, Higashida RT, Khatri P: Futile angiography reperfusion in the PROACT II Trial: An Exploratory Analysis. International Stroke Conference Scientific Sessions 2011. Los Angeles, California. February 9-11, 2011.

228. McDonald RL, Higashida RT, Keller E, Mayer SA, Molyneux AJ, RaabeA, Vajkoczy P, Wanke I, Bach D, Marr A, Roux S, Kassell NF: Effect of clazosentan on clinical outcome aftger aneurysmal subarachnoid hemorrhage and surgical clipping: Results of the CONSCIOUS-2 Study. International Stroke Conference, Annual Scientific Sessions. Los Angeles, CA. February 9-12, 2011.

229. Salsberg J, Tomsick T, Carrozzella J, Martin RL, Furlan A, Higashida RT, Dillon W, Broderick JP, Hill M, Khatri P: Futile Angiographic Reperfusion in the PROACT II Trial: An Exploratory Analysis. International Stroke Conference, Annual Scientific Sessions. Los Angeles, CA. February 9-12, 2011.

230. Parham M, Hetts S, English J, Halbach VV, Dowd CF, Higashida RT: Degree of Clot Enhancement on Admission CT Predicts Revascularization Efficacy in Acute Ischemic Stroke. International Stroke Conference 2012. Scientific Sessions. February 1-3, 2012. New Orleans, Louisiana.

231. MacDonald RL, Higashida RT, Keller E, Mayer SA, Molyneux AJ, Raabe A, Vajkoczy P, WAnke I, Bach D, Frey A, Nowbakht P, Roux S, Kassel N: Effect of Clazosentan on Clinical Outcome Afer Aneurysmal Subarachnoid Hemorrhage and Endovascular Coiling. Results of the CONSCIOUS-3 Study. International Stroke Conference, Scientific Session. February 1-3, 2012. New Orleans, Louisiana.

232. Guo Y, Saunders T, Su H, Kim H, Young WL, Higashida RT, for the UCSF Brain AVM Study Project. Silent intra-lesional micro hemorrhages as a risk factor for brain AVM rupture. International Stroke Conference, Scientific Session. February 1-3, 2012. New Orleans, Louisiana.

233. Hetts SW, Tsai T, Cooke DL, Amans MR, Dowd CF, Higashida RT, Halbach VV. De Novo, Progressive, Multiple, and Recurrent Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. World Federation of Interventional and Therapeutic Neuroradiology. Buenos Aires, Argentina. November 2013.

234. Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular Biopsy: Evaluating the feasibility of Harvesting Endothelial Cells Using Detachable Coils. World Federation of Interventional and Therapeutic Neuroradiology, Buenos Aires, Argentina, November 2013.

235. Cooke DL, Stout CE, Kim WT, Kansagra A, Yu JP, Hetts SW, Higashida RT, Dowd CF, Halbach VV. Cerebral Arterial Fenestrations and Their Significance. World Federation of Interventional and Therapeutic Neuroradiology, Buenos Aires, Argentina, November 2013.

236. Hetts SW, Cooke DL, Nelson J, Gupta N, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H. Angioarchitecture of Brain AVMs: Age-Dependent Changes. International Stroke Conference. San Diego, CA. February 2014.

237. Chow M, Cooke DL, Fullerton HJ, Amans MR, Narvid J, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Vein of Galen Malformations: Radiological and Clinical Features and Treatment

161 of 193 Prepared: October 27, 2015

Outcomes. American Society of Neuroradiology. Annual Scientific Meeting. Montreal, Canada. May 2014.

238. Moftakhar PM, Cooke DL, Ko NU, Fullerton HJ, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Cerebral Vasospasm in Children. American Society of Neuroradiology Annual Scientific Meeting. Montreal, Canada. May 2014.

241.

National Scientific Presentations

242. "Selective precapillary hypoxemia causes pulmonary vasoconstriction", Higashida RT, Spannhake E, Kadowitz P, Hyman A. American Heart Association, Section of Cardiopulmonary Physiology, 51st Scientific Session, Dallas, TX, November 1978.

243. "Pulmonary vascular responses to Angiotensin I, II, and III in intact cats". Hyman A, Chapnick B, Feigen L, Higashida RT, Kadowitz, American Heart Association, 51st Scientific Session, Dallas, TX , November 1978.

244. "Complications of long-term pediatric total parenteral nutrition: Role of ultrasound", Higashida RT, Diament M, Kangarloo H. Society for Pediatric Radiology, Annual Scientific Meeting, Atlanta, GA, April 1983.

245. "Iodine dose enhancement radiation therapy of tumors: Development of animal model using VX-2 carcinoma", Cochran S, Higashida RT, Winter J. Association of University Radiologists, May 1984.

246. "Comparative survival of iodine dose enhancement radiation therapy and conventional fractionated radiation therapy in rabbit VX-2 brain tumor." Cochran S, Higashida RT, Winter J, Norman A, Radiological Society of North America, 70th Annual Scientific Assembly, Chicago, IL, November 1984.

247. "Advances in the management options of carotid cavernous fistulae", Hieshima GB, Bentson JR, Higashida RT, Mehringer CM, Tsai FY, Pribram HW. American Society of Neuroradiology, New Orleans, LA, February 1985.

248. "Magnetic resonance imaging of the orbital apices, cavernous sinuses and related cranial nerves", Bentson JR, Rauschning W, Hieshima GB, Lufkin R, Higashida RT, Wilson GH. American Society of Neuroradiology, New Orleans, LA, February 1985.

249. "Detachable balloon occlusion of aneurysms", Higashida RT, Hieshima GB, Konishi Y, Helmer E, Bentson JR, Takeuchi K, Congress of Neurological Surgeons, 30th Annual Meeting, Maui, Hawaii, October 1985.

162 of 193 Prepared: October 27, 2015

250. "Intravascular embolization of carotid cavernous sinus fistulae: Therapeutic results in 152 cases", Higashida RT, Hieshima GB, Bentson JR. Congress of Neurological Surgeons, 30th Annual Meeting, Maui, Hawaii, October 1985.

251. "Percutaneous transluminal angioplasty of subclavian steals", Tsai FY, Yoon JW, Hieshima GB, Tiu D, Higashida RT, Pribram HF, Radiological Society of North America, 71st Scientific Assembly, Chicago, IL, November 1985.

252. "Transluminal angioplasty of the vertebral and basilar artery", Higashida RT, Hieshima GB, Bentson J. American Society of Neuroradiology, 24th Annual Session, San Diego, CA, January 1986.

253. "High flow dural arteriovenous fistulae in the region of the transverse, sigmoid and straight sinuses", Ishii K, Goto K, Hieshima GB, Bentson JR, Higashida RT, Reicher MA, Halbach VV. American Society of Neuroradiology, 24th Annual Session, San Diego, CA, January 1986.

254. "UCLA experience with spinal radiculomedullary vascular malformations". Cahan LD, Higashida RT, Bentson JR, Hieshima GB. American Association of Neurological Surgeons, Annual Scientific Assembly, San Diego, CA, February 1986.

255. "Neurological evaluation of patients during intravascular balloon embolizations for posterior cerebral circulation aneurysms", Wapenski JA, Hieshima GB, Higashida RT, Bentson JR, Halbach VV. American Association of Neurology, New Orleans, LA, November 9-13, 1986.

256. "Advances in the diagnosis and treatment of carotid cavernous fistulae", Hieshima GB, Higashida RT, Halbach VV. American Academy of Ophthalmology Annual Scientific Meeting, New Orleans, LA, November 9-13, 1986.

257. "Treatment of intracranial aneurysms by detachable balloon embolization therapy", Higashida RT, Hieshima GB, Halbach VV, Bentson JR, Newton TH, Norman D. Radiological Society of North America, 72nd Scientific Meeting, Chicago, IL, November 30-December 5, 1986.

258. "Treatment of carotid-cavernous sinus fistulas by the transvenous approach", Hieshima GB, Higashida RT, Halbach VV, Pribram HF, Mehringer CM, Dublin A. Radiological Society of North America, 72nd Scientific Meeting, Chicago, IL, November 30-December 5, 1986.

259. "Treatment of dural arteriovenous fistulas involving the cavernous, sigmoid and transverse sinuses", Halbach VV, Higashida RT, Hieshima GB, Goto K, Bentson JR, Newton TH, Norman D. Radiological Society of North America, 72nd Scientific Meeting, Chicago, IL, November 30- December 5, 1986.

260. "A new catheter for selective angiography, embolization, and regional perfusion", Kikuchi Y, Strother CM, Berenstein A, Hieshima GB, Turski P, Choi I, Higashida RT, Gentry L, Halbach VV. Radiological Society of North America, 72nd Scientific Assembly, Chicago, IL, November 30- December 5, 1986.

261. "Intravascular embolization of direct carotid cavernous sinus fistulas: Therapeutic results in 122 cases", Higashida RT, Hieshima GB, Halbach VV, Mehringer CM, Goto K, Pribram HF, Newton TH, Norman D. Radiological Society of North America, 72nd Scientific Assembly, Chicago, IL, November 30-December 5, 1986.

163 of 193 Prepared: October 27, 2015

262. "Embolotherapy of large and giant cavernous artery aneurysms by intravascular occlusion". Higashida RT, Wapenski J, Halbach VV, Hieshima GB. American Academy of Neurology, 39th Annual Meeting, New York, NY, April 5-11, 1987.

263. "Intravascular balloon embolization therapy for intracranial aneurysms", Higashida RT, Hieshima GB, Halbach VV, Cahan L. Annual Meeting of the American Association of Neurological Surgeons. Dallas, TX, May 3-7, 1987.

264. "Non-operable treatment of intracranial aneurysms", Higashida RT, Halbach VV, Hieshima GB, Yang P. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10- 15, 1987.

265. "MRI evaluation of neurovascular disorders using cine short TR gradient imaging", Tsuruda J, Halbach VV, Higashida RT, Hieshima G, Norman D. American Society of Neuroradiology. 25th Annual Meeting, New York, NY, May 10-15, 1987.

266. "Treatment of intracranial aneurysms with mass effect by transvascular balloon embolization". Halbach VV, Higashida RT, Hieshima GB. American Society of Neuroradiology. 25th Annual Meeting, New York, NY, May 10-15, 1987.

267. "Transluminal angioplasty of intracranial arterial vasospasm", Higashida RT, Halbach VV, Hieshima GB, Brant-Zawadzki M. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10-15, 1987.

268. "Normal perfusion breakthrough occurring during treatment of carotid and vertebral fistulas", Halbach VV, Higashida RT, Hieshima GB, Norman D. American Society of Neuroradiology, 25th Annual Meeting, New York, NY, May 10-15, 1987.

269. "Percutaneous transluminal angioplasty of subclavian, vertebral and basilar arteries: Indications and techniques", Higashida RT, Halbach VV, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

270. "Intravascular embolization of radiculomedullary and intramedullary spinal arterial venous malformations", Higashida RT, Halbach VV, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

271. "Low viscosity hydrophilic polymer HEMA for detachable balloons", Goto K, Halbach VV, Higashida RT, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

272. "Pre-operative occlusion of cerebral arteriovenous malformations", Halbach VV, Higashida RT, Hieshima GB, Hardin C. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

273. "Intravascular surgery for the treatment of posterior circulation intracranial aneurysms", Higashida RT, Halbach VV, Hieshima GB. Radiological Society of North America, 73rd Scientific Assembly, Chicago, IL, November 29-December 4, 1987.

274. "Platinum wire: A new transvascular embolic agent", Yang P, Halbach VV, Higashida RT, Hieshima GB, Siegel RS. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

164 of 193 Prepared: October 27, 2015

275. "Transvenous embolization of direct carotid cavernous fistulas", Halbach VV, Higashida RT, Hieshima GB, Hardin C, Yang P. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

276. "Therapeutic approaches in the management of head and neck pseudoaneurysms", Kwan ES, Higashida RT, Halbach VV, Hieshima GB. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

277. "Transvenous embolization of dural fistulas involving the transverse and sigmoid sinuses", Halbach VV, Higashida RT, Hieshima GB, Mehringer CM, Hardin C. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

278. "Treatment of posterior fossa intracranial aneurysms by interventional neurovascular embolization techniques", Higashida RT, Halbach VV, Norman D, Newton TH, Hieshima GB. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

279. "A new microballoon device for angioplasty of intracranial arterial vasospasm", Higashida RT, Halbach VV, Dormandy B, Bell J, Norman D, Hieshima GB. 26th Annual Meeting, American Society of Neuroradiology, Chicago, IL, May 15-20, 1988.

280. "Transluminal angioplasty of intracranial vasospasm using a new type of silicone microballoon", Higashida RT, Halbach VV, Dormandy B, Bell J, Hieshima GB. Radiological Society of North America, 74th Scientific Session, Chicago, IL, December, 1988.

281. "Complex dural arteriovenous fistulas: Results of combined endovascular and neurosurgical therapy", Barnwell SL, Halbach VV, Higashida RT, Hieshima GB, Wilson C, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

282. "Vascular malformations of the spinal cord: MR spectrum and pitfalls", Gaensler EHL, Dillon WP, Tsuruda J, Halbach VV, Higashida RT, Hieshima GB, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

283. "Embolization of branches arising from the cavernous internal carotid artery", Halbach VV, Higashida RT, Hieshima GB, Hardin C, Barnwell SL, Dowd CF, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

284. "Cirsoid aneurysms: Results of endovascular treatment in nine patients", Barnwell SL, Halbach VV, Dowd C, Higashida RT, Hieshima GB, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

285. "Treatment of traumatic carotid and vertebral artery lesions by interventional neurovascular techniques", Higashida RT, Halbach VV, Hieshima GB, Tsai F, Norman D, Pribram HF, Mehringer CM, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

286. "Treatment of surgically inaccessible cavernous carotid artery aneurysms by detachable balloon embolization techniques", Higashida RT, Halbach VV, Hieshima GB, Barnwell S, Dowd C, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

287. "Technical aspects of intracranial aneurysm therapy by endovascular occlusive techniques", Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB, American Society of Neuroradiology, 27th National Meeting, Orlando, Florida, March 1989.

165 of 193 Prepared: October 27, 2015

288. "Complications of intracranial aneurysm therapy and vascular malformation therapy." Higashida RT, Halbach VV, Hieshima GB. Second Annual Meeting on Complications in Interventional Neuroradiology. San Francisco, California. August 1989.

289. "Transfemoral venous embolization of vein of Galen Malformations", Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB. Radiological Society of North America, 75th Scientific Annual Meeting, Chicago, Illinois. November 1989.

290. "Treatment of intracranial arterial vasospasm by transluminal angioplasty techniques: Clinical experience", Higashida RT, Halbach VV, Dormandy B, Bell J, Barnwell SL, Dowd C, Hieshima GB. Radiological Society of North America, 75th Scientific Annual Meeting, Chicago, Illinois. November 1989.

291. "Endovascular detachable balloon occlusion therapy for treatment of complex intracranial aneurysms: Technical considerations". Higashida RT, Halbach VV, Dormandy B, Bell J, Dowd CF, Barnwell SL, Hieshima GB. Radiological Society of North America, 75 h Scientific Annual Meeting, Chicago, Illinois. November 1989.

292. "Management of vascular perforations occurring during endovascular procedures." Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. American Society of Neuroradiology, 28th National Meeting, Los Angeles, California, March 1990.

293. "Transfemoral venous embolization of vein of Galen malformations." Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB. American Society of Neuroradiology, 28th National Meeting, Los Angeles, California, March 1990.

294. Treatment of petrous carotid aneurysms." Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. American Society of Neuroradiology, 28th National Meeting, Los Angeles, California, March 1990.

295. "Percutaneous transluminal angioplasty for intracranial arterial vasospasm". Higashida RT, Halbach VV, Barnwell SL, Dowd CR, Dormandy B, Bell JB, Hieshima GB. American Society of Neuroradiology, 28th National Meeting, Los Angeles, California, March 1990.

296. "Intravascular detachable balloon embolization therapy of intracranial aneurysms with preservation of the parent vessel". Higashida RT, Halbach VV, Dormandy B, Bell J, Dowd CF, Barnwell SL, Hieshima GB. American Society of Neuroradiology, 28th National Meeting, Los Angeles, California, March 1990.

297. "Endovascular thrombolytic therapy for dural sinus thrombosis". Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Wilson CB. American Association of Neurological Surgeons, Nashville, Tennessee, April 1990.

298. "Multiple dural arteriovenous fistulas of the cranium and spine: Endovascular and surgical therapy". Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Wilson CB. American Association of Neurological Surgeons, Nashville, Tennessee, April 1990.

299. "Dural arteriovenous fistulas involving the inferior petrosal sinus". Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Wilson CB. American Association of Neurological Surgeons, Nashville, Tennessee, April 1990.

166 of 193 Prepared: October 27, 2015

300. "A variant of arteriovenous fistulas within the wall of dural sinuses: Results of combined surgical and endovascular therapy". Barnwell SL, Halbach VV, Dowd CF, Higashida RT, Hieshima GB, Wilson CB. American Association of Neurological Surgeons, Nashville, Tennessee, April 1990.

301. "Endovascular coil embolization of intracerebral aneurysms.: Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB. Radiological Society of North America. 76th Scientific Annual Meeting. Chicago, Illinois. November 25-30, 1990.

302. "Transluminal angioplasty of symptomatic intracranial arterial vasospasm." Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB. Radiological Society of North America. 76th Scientific Annual Meeting. Chicago, Illinois. November 25-30, 1990.

303. "Interventional neurovascular treatment of intracranial aneurysms by detachable balloons: results in 215 cases. Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB. Radiological Society of North America. 76th Scientific Annual Meeting. Chicago, Illinois. November 25-30, 1990.

304. "Advances in endovascular treatment of traumatic carotid and vertebral artery lesions." Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB. Radiological Society of North America. 76th Scientific Annual Meeting. Chicago, Illinois. November 25-30, 1990.

305. "Treatment of giant perimedullary fistulas." Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL. American Society of Neuroradiology. 29th Scientific Annual Meeting. Washington, D.C. June 9-14, 1991.

306. "Acute thrombosis of the superior sagittal sinus: Thrombolytic therapy." Tsai FY, Matovich VB, Higashida RT. American Society of Neuroradiology. 29th Scientific Annual Meeting. Washington, D.C. June 9-14, 1991.

307. "Endovascular balloon occlusion of the basilar artery in the treatment of mid basilar aneurysms." Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB. American Society of Neuroradiology. 29th Scientific Annual Meeting. Washington, D.C. June 9-14, 1991.

308. "Clinical experience following balloon dilatation in intracranial arterial vasospasm". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Radiological Society of North America. Seventy-seventh Scientific Assembly and Annual Meeting. December 1-6,1991. Chicago, Illinois.

309. "Transluminal angioplasty for cerebrovascular disease of the posterior circulation." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Radiological Society of North America. Seventy-seventh Scientific Assembly and Annual Meeting. December 1-6,1991. Chicago, Illinois.

310. "Treatment of symptomatic intracranial arterial vasospasm by transluminal angioplasty." Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB. American Association of Neurological Surgeons Annual Meeting. San Francisco, California. April 1992.

311. "The effectiveness of endosaccular aneurysm occlusion in alleviating the neurological deficits producing mass effect." Halbach VV, Higashida RT, Dowd CF, Barnwell SL, Hieshima GB. American Association of Neurological Surgeons Annual Meeting. San Francisco, California. April 1992.

167 of 193 Prepared: October 27, 2015

312. "Thrombolytic treatment of dural sinus thrombosis." Smith T, Fraser K, Higashida RT, Halbach VV, Dowd CF, Tsai FY, Hieshima GB. Annual Meeting of the Society of Cardiovascular and Interventional Radiology. Washington, D.C. April 1992.

313. "Complications associated with endovascular surgery for intracranial aneurysms.: Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. Annual Morbidity and Mortality Conference. Jackson Hole, Wyoming. August 1992.

314. "Complications associated with endovascular therapy for complex cerebral arteriovenous malformations." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. Annual Morbidity and Mortality Conference. Jackson Hole, Wyoming. August 1992.

315. "Complications associated with interventional treatment of cerebral arterial vasospasm." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. Annual Morbidity and Mortality Conference. Jackson Hole, Wyoming. August 1992.

316. "Complications associated with endovascular treatment of intracranial and extracranial arteriovenous fistulas." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Hieshima GB. Annual Morbidity and Mortality Conference. Jackson Hole, Wyoming. August 1992.

317. "Transarterial embolization of vertebral hemangiomas." Smith TP, Koci T, Mehringer CM, Tsai FY, Fraser KW, Dowd CF, Higashida RT, Halbach VV, Hieshima GB. 18th Annual Meeting of the Society of Cardiovascular and Interventional Radiology. New Orleans, Louisiana. March 1993.

318. "PreOperative external carotid artery embolization of meningiomas." Smith TP, Fraser KW, Teitelbaum GP, Dowd CF, Higashida RT, Halbach VV, Hieshima GB. 18th Annual Meeting of the Society of Cardiovascular and Interventional Radiology. New Orleans, Louisiana. March 1993.

319. "Bilateral cavernous sinus for adrenocorticotropin hormone". Fraser KW, Halbach VV, Smith TP, Dowd CF, Higashida RT, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

320. "Development of acquired arteriovenous fistulas in rats by venous hypertension". Terada T, , Higashida RT, Halbach VV, Dowd CF, Tsuura M, Komai N, Wilson C, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

321. "The role of angiogenetic factor, bFGF, in the development of dural arteriovenous fistulas". Terada T, , Higashida RT, Halbach VV, Dowd CF, Tsuura M, Komai N, Wilson C, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

322. "Endovascular treatment of vertebral artery dissections and pseudoaneurysms." Halbach VV, Higashida RT, Dowd CF, Smith TP, Fraser KW, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

323. "Transfemoral superior ophthalmic vein approach in the treatment of cavernous dural arteriovenous fistulas." Dowd CF, Halbach VV, Higashida RT, Smith TP, Fraser KW, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

168 of 193 Prepared: October 27, 2015

324. "Endovascular treatment of giant anterior circulation intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Smith TP, Fraser KW, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

325. "Transluminal angioplasty of the vertebral and basilar arteries for posterior fossa ischemia." Higashida RT, Halbach VV, Dowd CF, Smith TP, Fraser KW, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

326. "Evaluation of the electrolytically detachable platinum coil for the treatment of fusiform aneurysms and fistulae." Halbach VV, Higashida RT, Dowd CF, Smith TP, Fraser KW, Teitelbaum GP, Hieshima GB. 31st Annual Scientific Meeting of the American Society of Neuroradiology. May 13-20, 1993. Vancouver, Canada.

327. "Complications resulting from endovascular embolization of cerebral arteriovenous malformations." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The 6th Annual Morbidity and Mortality Conference in Interventional Neuroradiology. Jackson Hole, Wyoming. August 1993.

328. "Complications of intracranial aneurysm therapy." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The 6th Annual Morbidity and Mortality Conference in Interventional Neuroradiology. Jackson Hole, Wyoming. August 1993.

329. "Dural arteriovenous fistulas: Pathogenesis and progression." Hieshima GB, Higashida RT, Halbach VV, Dowd C, Wilson C, Terada T. American Academy of Neurological Surgery. 55th Annual Meeting. Litenfeld Park, Arizona. October 27-30, 1993.

330. "Interventional neurovascular treatment of giant intracranial aneurysms". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. Society of Cardiovascular and Interventional Radiology. Annual Meeting. San Diego, California. March 19-24, 1994.

331. "Cerebral percutaneous transluminal angioplasty". Higashida RT, Tsai FY, Halbach VV, Dowd CF, Hieshima GB. Society of Cardiovascular and Interventional Radiology. Annual Meeting. San Diego, California. March 19-24, 1994.

332. "Endovascular treatment of giant intracerebral aneurysms". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons. Annual Scientific Meeting. San Diego, California. April 10-14, 1994.

333. "Endovascular management of intracerebral arteriovenous malformations". Higashida RT, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons. Annual Scientific Meeting. San Diego, California. April 10-14, 1994.

334. "Direct fibrinolytic therapy for acute thromboembolic disease of the intracranial circulation." Higashida RT, Halbach VV, Barnwell SL, Dowd CF, Hieshima GB. American Society of Neuroradiology. Annual Scientific Meeting. Nashville, Tennessee. May 1-7, 1994.

335. "The effect of estrogen for the development of arteriovenous fistulae." Terada T, Higashida RT, Halbach VV, Dowd CF, Hieshima GB. American Society of Neuroradiology. Annual Scientific Meeting. Nashville, Tennessee. May 1-7, 1994.

169 of 193 Prepared: October 27, 2015

336. "Metallic fragment emboli resulting from treatment with electrolytically detachable coils." Halbach VV, Dowd CF, Higashida RT, Larsen DW, McDougall CG, Teitelbaum GP, Hieshima GB. American Society of Neuroradiology. Annual Scientific Meeting. Nashville, Tennessee. May 1-7, 1994.

337. "Factors that influence the production of metallic fragments during electrolysis of electrolytically detachable coils." Halbach VV, Dowd CF, Higashida RT, Larsen DW, McDougall CG, Teitelbaum GP, Hieshima GB. American Society of Neuroradiology. Annual Scientific Meeting. Nashville, Tennessee. May 1-7, 1994.

338. "Complications resulting from cerebral percutaneous transluminal angioplasty." Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D, Hieshima GB. The 7th Annual Meeting of Peer Review in Interventional Neuroradiology. Jackson Hole, Wyoming. July 5-9, 1994.

339. "Complications resulting from endovascular treatment of cerebral arteriovenous malformations." Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D, Hieshima GB. The 7th Annual Meeting of Peer Review in Interventional Neuroradiology. Jackson Hole, Wyoming. July 5-9, 1994.

340. "Interventional treatment of giant intracranial aneurysms: Technical strategies and results." Higashida RT, Halbach VV, Dowd CF, McDougall C, Larsen D, Hieshima G: The 80th Annual Scientific Meeting of the Radiological Society of North America. Chicago, Illinois. November 27- December 2, 1994.

341. "Endovascular aneurysm therapy wit electrolytically detachable coils: Initial experience in 94 patients." Dowd CF, Halbach VV, Higashida RT, McDougall C, Larsen D, Hieshima G: The 80th Annual Scientific Meeting of the Radiological Society of North America. Chicago, Illinois. November 27-December 2, 1994.

342. "Intraoperative spinal angiography for arteriovenous malformations." Dreyer FW, Higashida RT, Dowd CF, DePrima SJ, Fraser KW. : The 80th Annual Scientific Meeting of the Radiological Society of North America. Chicago, Illinois. November 27-December 2, 1994.

343. "Endovascular management of acute traumatic vascular injuries to the head and neck: Therapeutic options." Higashida RT, Society of Cardiovascular and Interventional Radiology. 20th Annual Scientific Session. March 25-30, 1995. Ft. Lauderdale, Florida.

344. "Acute thrombolytic therapy in stroke: Technique and Results." Higashida RT Society of Cardiovascular and Interventional Radiology. 20th Annual Scientific Session. March 25-30, 1995. Ft. Lauderdale, Florida.

345. "Diagnosis and management of spinal dural arteriovenous fistulas." Larsen DW, Halbach VV, Higashida RT, Dowd CF, McDougall CG, Hieshima GB." Society of Cardiovascular and Interventional Radiology. 20th Annual Scientific Session. March 25-30, 1995. Ft. Lauderdale, Florida.

346. "Endovascular treatment of basilar tip aneurysms using electrolytically detachable coils." McDougall CG, Halbach VV, Higashida RT, Dowd CF, Larsen DW. American Association of Neurological Surgeons. 63 rd Annual Meeting. Orlando, Florida. April 22-27, 1995.

170 of 193 Prepared: October 27, 2015

347. "Acute thrombolytic therapy in Stroke: Technique and Results". Higashida RT, Barnwell SL, Halbach VV, Dowd CF, Hieshima GB. American Association of Neurological Surgeons. Annual Meeting. Orlando, Florida. April 22-27, 1995.

348. "Transluminal angioplasty of extra and intracranial cerebral vascular disease." Higashida RT, American Society of Interventional and Therapeutic Neuroradiology and the American Society of Neuroradiology. Annual Scientific Society Meeting. April 21-27, 1995. Chicago, Illinois.

349. "Endovascular aneurysm therapy with electrolytically detachable coils: Initial Experience." Dowd CF, Halbach VV, Higashida RT, McDougall CG, Larsen DW, Teitelbaum GP, Hieshima GB. American Society of Interventional and Therapeutic Neuroradiology and the American Society of Neuroradiology. Annual Scientific Society Meeting. April 21-27, 1995. Chicago, Illinois.

350. "Treatment of dural arteriovenous fistulas." Halbach VV, Larsen DW, Higashida RT, Dowd CF, McDougall CG, Hieshima GB. American Society of Interventional and Therapeutic Neuroradiology and the American Society of Neuroradiology. Annual Scientific Society Meeting. April 21-27, 1995. Chicago, Illinois.

351. "Complications of endovascular aneurysm therapy." McDougall C, Halbach VV, Dowd CF, Higashida RT, Hieshima GB. The 8 h Annual Peer Review Conference in Interventional Neuroradiology. Jackson Hole, Wyoming. August 1-5, 1995.

352. "Complications of interventional treatment of AVM's." Halbach VV, Dowd CF, Higashida RT, Hieshima GB. The 8th Annual Peer Review Conference in Interventional Neuroradiology. Jackson Hole, Wyoming. August 1-5, 1995.

353. "Complications of endovascular percutaneous transluminal angioplasty therapy." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. The 8th Annual Peer Review Conference in Interventional Neuroradiology. Jackson Hole, Wyoming. August 1-5, 1995.

354. "PROACT and the clinical Trials Acceleration Program: Lessons about hyperacute stroke care in North America." Furlan AJ, Putney K, Barker W, Banet G, Bell, Berguer, Clark WY, Curtain, Del Zoppo G, Fayad P, Fullerton T, Greenlee R, Higashida R, et al. Annual American Heart Association Meeting. San Antonio, Texas. February 1995.

355. "Endovascular treatment of ruptured intracranial aneurysms using electrolytically detachable coils." McDougall C, Halbach VV, Dowd CF, Larsen D, Higashida RT, Hieshima GB. The 45th Annual Scientific Meeting of the Congress of Neurological Surgeons. San Francisco, California. October 14-19, 1995.

356. "Interventional neurovascular treatment of intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Hieshima GB. . The 45th Annual Scientific Meeting of the Congress of Neurological Surgeons. San Francisco, California. October 14-19, 1995.

357. "Acute middle cerebral artery thrombosis: Neuroradiologic findings in the PROACT study." Rowley H, del Zoppo GJ, Higashida RT, Furlan T, and the Proact Investigators. The American Society of Neuroradiology Annual Scientific Meeting. Seattle, Washington. June 22-27, 1996.

358. "Complications of endovascular surgery for intracranial aneurysms." Higashida RT, Dowd CF, Halbach VV. 9th Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 30-August 3, 1996.

171 of 193 Prepared: October 27, 2015

359. "Complications of endovascular surgery for cerebral AVM's." Dowd CF, Halbach VV, Higashida RT. 9th Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 30-August 3, 1996.

360. "Cavernous internal carotid artery aneurysms treated with electrolytically detachable coils." Halbach VV, Higashida RT, Dowd CF, Urwin RW, Balousek PA, Lempert TE, Hieshima GB. The 65th Annual Meeting of the American Association of Neurological Surgeons. Scientific Program. April 12-17, 1997. Denver, Colorado.

361. "Endovascular treatment of vertebral dissecting aneurysms." Halbach VV, Higashida RT, Dowd CF. Winter Neurosurgical Conference. March 1-8, 1997. Alberta, Canada.

362. "Endovascular treatment of fusiform basilar aneurysms." Halbach VV, Higashida RT, Dowd CF. Winter Neurosurgical Conference. March 1-8, 1997. Alberta, Canada.

363. "A new embolic device: Fibered detachable coils." Halbach VV, Higashida RT, Dowd CF. Winter Neurosurgical Conference. March 1-8, 1997. Alberta, Canada.

364. "Focal foramenal enhancement sign. Localization of spinal dural arteriovenous fistula site with gadolinium enhanced 3D TOF MRA." Kane AG, Dowd CR, Barkovich AJ, Halbach VV, Higashida RT, Hieshima GB. American Society of Neuroradiology. 35th Annual Meeting. Toronto, Canada. May 18-22, 1997.

365. "Complications resulting from cerebral artery angioplasty and stenting". Higashida RT, Dowd CF, Halbach VV. 10th Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 29-August 2, 1997.

366. "Complications resulting from intracranial aneurysm therapy". Higashida RT, Dowd CF, Halbach VV. 10 h Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 29-August 2, 1997.

367. "Endovascular complications during intracranial aneurysm therapy." Higashida RT, Dowd CF, Halbach VV. 11th Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 6-July 10, 1998.

368. "Endovascular complications during intracranial thrombolytic therapy." Higashida RT, Dowd CF, Halbach VV. 11th Interventional Neuroradiology Peer Review Conference. Jackson Hole, Wyoming. July 6-July 10, 1998.

369. "ProACT II: Recombinant ProUrokinase in Acute Cerebral Thromboembolism: Initial Trial results-The Proact II Investigators." Furlan A, Higashida RT, Wexler L, and the Proact Investigators. 24th Annual Meeting of the American Heart Association: Stroke Council. February 4-6, 1999. Nashville, Tennessee.

370. "Comparison of short-term outcomes of surgical clipping and endovascular coiling in treatment of unruptured cerebral aneurysms. Johnston SC, Wilson CB, Halbach VV, Higashida RT, Dowd CF, Lawton MT, McDermott MW, Appleburry CB, Farley TL, Gress DR. Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. January 31, 1999 - February 3 ,1999. Nashville, Tennessee.

172 of 193 Prepared: October 27, 2015

371. "Dural arteriovenous fistulas of the superior petrosal sinus: Combined endovascular and surgical management. Malek A, Halbach VV, Balousek PA, Lempert TE, Higashida RT, Dowd CF, Hieshima GB, Wilson CB. Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. January 31, 1999 - February 3 ,1999. Nashville, Tennessee.

372. "Balloon assist technique for endovascular coil embolization of wide-necked aneurysms: A series of 20 patients. Malek A, Halbach VV, Higashida RT, Phatouros CC, Lempert TE, Dowd CF. Second Annual Joint Conference of the Joint Section of Cerebrovascular Surgery and the American Society of Interventional and Therapeutic Neuroradiology. January 31, 1999 - February 3 ,1999. Nashville, Tennessee.

373. "Comparison of surgical clipping and endovascular coil embolization in the treatment of unruptured cerebral aneurysms." Johnston CS, Wilson CB, Halbach VV, Higashida RT, Dowd CF, Lawton MT, McDermott MW, Applebury CB, Farley TL, Gress DR. Annual Scientific Meeting of the American Association of Neurological Surgeons. April 25-29, 1999. New Orleans, Louisiana.

374. "Complications of acute stroke therapy interventions." Higashida RT Fourteenth Annual Cerebrovascular Complications Meeting. Jackson, Wyoming. July 28-August 1, 1999.

375. "Symptomatic intracranial hemorrhage after intra-arterial thrombolysis with recombinant Pro Urokinase in acute ischemic stroke: The Proact II study". Kase C, Furlan T, Higashida RT, Wechsler L, and the Proact II Investigators. American Academy of Neurology. May 1-5, 2000. San Diego, California.

376. "Time to treatment and neurological outcome in the Proact II Study". Kase C, Furlan T, Higashida RT, Wechsler L, and the Proact II Investigators. American Academy of Neurology. May 1-5, 2000. San Diego, California.

377. "Intracranial stenting for atherosclerotic disease." Malek A, Higashida RT, Halbach VV, Dowd CF. Annual Scientific Meeting of the American Association of Neurological Surgeons. April 9-14, 2000. San Francisco, California.

378. "CT Findings in the Proact II Trial". Rowley H, Dillon W, Roberts H, Higashida RT, Furlan A, and the Proact Investigators. Annual Meeting of the American Society of Neuroradiology. April 2-6, 2000. Atlanta, Georgia.

379. "Treatment of intracranial atherosclerotic disease using stent-supported angioplasty: A series of 24 patients". Malek A, Higashida RT, Halbach VV, Dowd CF. Congress of Neurological Surgeons Annual Meeting. September 23-28, 2000. San Antonio, Texas.

380. "Coil Occlusion of Giant Partially Thrombosed fusiform PCA Aneurysm with resulting stroke". Dowd CF, Higashida RT, Halbach VV. 13th Annual Neurointerventional Peer Review Conference. Jackson, Wyoming. June 25-29, 2000.

381. "PTA of preclusive supraclinoid ICA stenosis with resulting cerebral hemorrhage". Higashida RT, Dowd CF, Halbach VV. 13th Annual Neurointerventional Peer Review Conference. Jackson, Wyoming. June 25-29, 2000.

173 of 193 Prepared: October 27, 2015

382. "Ethanol embolization of a torcular DAVF via Davidoff-Schechter artery with midbrain and vermian sequelae". Meyers P, Dowd CF, Higashida RT, Halbach VV. 13th Annual Neurointerventional Peer Review Conference. Jackson, Wyoming. June 25-29, 2000.

383. "Delayed 3D GDC coil displacement from a wide-necked ICA aneurysm producing TIAs". Lefler J, Dowd CF, Higashida RT, Halbach VV. 13th Annual Neurointerventional Peer Review Conference. Jackson, Wyoming. June 25-29, 2000.

384. "Management of Mycotic Intracranial Aneurysms: Experience with nineteen patients." Lawton MT, Chun J, Wilson CB, Smith WS, Halbach VV, Higashida RT. Annual Meeting of the Western Neurosurgical Society. Mauna Lani Bay, Kohala Coast, Hawaii. September 12-15, 2000.

385. "Endovascular treatment of ruptured posterior circulation cerebral aneurysms: Clinical and angiographic outcomes." Lempert TE, Malek AM, Halbach VV, Phatouros CC, Meyers PM, Dowd CF, Higashida RT. Annual Meeting of the Western Neurosurgical Society. Mauna Lani Bay, Kohala Coast, Hawaii. September 12-15, 2000.

386. "Treatment of intracranial atherosclerotic disease using stent-supported angioplasty". Malek AM, Higashida RT, Phatouros CC, Lempert T, Meyers P, Dowd CF, Halbach VV. Annual Meeting of the Congress of Neurological Surgeons. September 2000. San Antonio, Texas.

387. "Intracranial Stent Angioplasty for the treatment of symptomatic intracranial atherosclerotic disease. Malek A, Higashida RT, Halbach VV, Dowd CF. Joint Meeting of the Joint Section of Cerebrovascular Neurosurgery and the American Society of Interventional and Therapeutic Neuroradiology. Waikoloa, Hawaii. Feb 9-14, 2001.

388. "Endovascular Treatment of Anterior Circulation Aneurysms using the GDC System: Outcomes in a series of 296 patients. Malek A, Halbach VV, Dowd CF, Higashida RT. Annual Scientific Meeting of the American Association of Neurological Surgeons. April 21-25, 2001. Toronto, Ontario, Canada.

389. "GDC Coil Therapy of Basilar Artery Aneurysms: Clinical Experience and Long Term follow up in 126 patients. Malek A, Halbach VV, Dowd CF, Higashida RT. Annual Scientific Meeting of the American Association of Neurological Surgeons. April 21-25, 2001. Toronto, Ontario, Canada.

390. "Characteristics of Intracranial Arteriovenous Malformations associated with Cerebral Aneurysms". American Stroke Association Annual Scientific Meeting. Singh V, Johnston SC, Gress DR, Halbach VV, Lawton MT, Higashida RT, Dowd CR, Young WL. Tampa, Florida. February 13-16, 2001.

391. "Complications of Intracranial Stenting for Cerebral Atherosclerosis". Global Complications Meeting. Higashida RT, Dowd CF, Halbach VV. Jackson, Wyoming. July 25-28, 2001.

392. "Complications of Acute Stroke Therapy Treatments". Higashida RT, Dowd CF, Halbach VV. Interventional Neuroradiology Morbidity and Mortality Conference. July 31-August 4, 2001. Jackson, Wyoming.

393. Gupta D, Young W, Higashida R, Caragine LP, Lefler J, Quinnine N, Hashimoto T, Dowd C, Halbach V, Halim A: "The effect of nitric oxide synthase inhibition on hyperemia following

174 of 193 Prepared: October 27, 2015

transluminal cerebral angioplasty." The Society of Neuroanesthesia and Critical Care, October 2001.

394. Torbey MT, Hanley DF, Justason BJ, Clark MA, Tuden D, Higashida RT: The effect of clinical experience on treatment outcomes and Hospital Resource Use for Unruptured Cerebral Aneurysms. Annual Meeting of the American Association of Neurology. Denver, Colorado. April 13-20, 2002.

395. Higashida RT, Torbey MT, Hanley DF, Justason BJ, Clark MA, Tuden D: The effect of clinical experience on treatment outcomes and Hospital Resource Use for Unruptured Cerebral Aneurysms. Annual Meeting of the American Society of Neuroradiology. May 12-17, 2002. Vancouver, Canada.

396. "A comparison of endovascular vs. surgical treatment for unruptured cerebral aneurysms". Hopkins N, Higashida RT, Justason B. Annual Meeting of the Congress on Neurological Surgeons. September 2002. Philadelphia, Pennsylvania.

397. "Endovascular treatment of unruptured cerebral aneurysms may lead to improved outcomes and lower hospital resource use." Higashida RT, Justason BJ, Clark MA, Tuden D, Torbey MT, Hanley. 40 h Annual Scientific Meeting of the American Society of Neuroradiology. May 11-17, 2002. Vancouver, British Columbia, Canada.

398. "The effect of clinical experience on treatment outcomes and hospital resource use for unruptured cerebral aneurysms." Torbey M, Justason BJ, Hanley DF, Leip E, Hopkins LN, Higashida RT. American Heart Association 4th Scientific Forum on quality of Care and Outcome Research. Washington, DC. September 2002.

399. "Complications resulting from Endovascular Treatment of Acute Vertebral Artery Dissections". Higashida RT, Halbach VV, Dowd CF. Global Complications Meeting. Jackson, Wyoming. July 24-27, 2002.

400. "Complications of Endovascular Treatment of Cerebral Aneurysms". Higashida RT Annual Meeting of NeuroInterventional Morbidity/Mortality. Jackson, Wyoming. July 31-August 3, 2002.

401. "Concentric MERCI Retriever for the Treatment of Neurovascular Thrombotic Occlusions: A Phase I Non Randomized Trial". Higashida RT, Smith W, Sung E. Annual Scientific Meeting of the American Society of Neuroradiology. April 28-May 2, 2003. Washington, DC.

402. "Complications of Performing Intracranial Stenting for Complex Aneurysms" Higashida RT. Annual Meeting of the Global Complications Conference. Jackson, Wyoming. July 23-26, 2003.

403. "Endovascular Complications of Intracranial Aneurysm Therapy". Higashida RT, Annual Meeting of the NeuroInterventional Morbidity/Mortality Conference. Jackson, Wyoming. July 30- August 1, 2003.

404. "Complications of Endovascular Therapy of Dissecting Vertebral Aneurysms". Higashida RT. 1st Annual ASITN Course and Workshop. Boca Raton, Florida, August 10-15, 2004.

175 of 193 Prepared: October 27, 2015

405. "Complications of Endovascular Therapy of Intracranial Angioplasty and Stenting". Higashida RT. 1st Annual ASITN Course and Workshop. Boca Raton, Florida, August 10-15, 2004.

406. Budzik RF, Higashida RT, for the MERCI Investigators Recanalization Rates and Outcomes in Patients with ICAT Stroke in the MERCI Trial. Abstract ICAT for ASITN Hawaii Workshop. June 30, 2005.

407. Duckwiler G, Higashida RT, for MERCI Trial Investigators Outcomes in Anterior Circulation Patients from the MERCI Trial Stratified by Onset to Groin Puncture and Recanalization. Hawaii Workshop. June 30, 2005

408. Duckwiler G, Higashida RT, for MERCI Trial Investigators Outcomes in Anterior Circulation Patients from the MERCI Trial Stratified by Onset of Groin Puncture and Recanalization. Presentation at the Annual Meeting of the American Society of Interventional Neuroradiology. September 2005.

409. Intravenous and Intra-arterial Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging of Meningiomas Before and After Embolization. Cha S, Martin A, Weber O, Mayo MC, Parsa A, McDermott M, Berger M, Dillon W, Higashida RT, Saloner D. American Society of Neuroradiology. Annual Scientific Meeting. Toronto, Canada. May 2006.

410. Kim D, Jahan R, Saver JL, Liebeskind DS, Vinuela F, Starkman S, Duckwiler G, Higashida RT, for the MERCI and Multi-MERCI Investigators Mechanical Thrombectomy with the Merci Retriever for Acute Stroke in Very Elderly Patients. ASITN 4th Annual Meeting, July 30-August 3, 2007 - Presentation.

411. "Radiographic Infarction in SAH is More Common in Patients Treated Surgically vs. Endovascularly: A Neurocritical Care Effect?". Ko N, Higashida RT. Annual Scientific Meeting of the Neurocritical Care Society. October 2008.

412. Ko N, Higashida RT, Young WL: Endothelial nitric oxide synthase polymorphism (eNOS- 786) and poor functional outcome after aneurysmsal subarachnoid hemorrhage. Annual Meeting of the Neurocritical Care Society. San Francisco, CA. October 2009.

413. Macdonald RL, Frey A, Higashida RT, Keller E, Marr A, Mayer SA, Molyneux A: Investigating the Efficacy and Safety of Clazosentan in Reducing Vasospasm-Related Morbidity and All-Cause Mortality after Aneurysmal Subarachnoid Hemorrhage (aSAH): The CONSCIOUS-2 and Conscious-3 Studies. Congress of Neurological Surgeons. San Francico, CA. October 2010.

414. Ko NU, Jordan J, Higashida RT, Lawton MT, Smith WS: Prevalence of mood disorders after aneurismal subarachnoid hemorrhage. American Neurological Association Annual Scientific Meeting. November 2010.

415. Hetts S, Kim W, Cooke D, English J, Gupta N, Stout C, Kim H, Dowd C, Halbach V, Higashida R, Lawton M, Young W: "Pediatric versus Adult AVM Angioarchitecture: Are Children Really Just Small Adults?" Society of NeuroInterventional Surgery, Annual Scientific Meeting. San Diego, California. July 23-27, 2012.

416. Fukuda K, Lawton MT, Smith WS, Higashida RT, Young WL, Obrist WD, Ko NU: "Increase in Quantitiative Cerebral Blood Flow after Endovascular Treatment for Refractory

176 of 193 Prepared: October 27, 2015

Vasospasm". 10th Annual Meeting of the Neurocritical Care Society. Denver, Colorado. October 4-7, 2012.

417. Hetts Sw, Marin AJ, Lum M, Dowd CF, Halbach VV, Higashida RT, McDermott, Saloner D: Intra-arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subratction Angiography. NIH National Center For Image Guided Therapy Workshop. 2013.

418. Cooke DL, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG. Dose reduction in transarterial melphalan infusion for intraocular retinoblastoma. American Society of Neuroradiology. Annual Scientific Meeting. San Diego, CA. May 2013.

419. Lum M, Martin A, Dowd CF, Halbach VV, Higashida RT, Cha S, Saloner D, Hetts SW. Intra-arterial MR Perfusion Analysis of Meningiomas: Comparison to Intravenous MR Perfusion and Digital Subtraction Angiography. American Society of Neuroradiology. Annual Scientific Meeting. San Diego, CA. May 2013.

420. Tsai T, Cooke DL, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. De Novo, Progressive, Multiple, and Recurrent Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. American Society of Neuroradiology, Can Diego, CA, May 2013.

421. Hetts S, Higashida RT, Halbach VV, Dowd CF: "Vein of Galen Malformations: Radiological and Clinical Features, and Long-Term Outcome following Endovascular Treatment". 52nd Annual Meeting. American Society of Neuroradiology. May 19-22, 2014. Montreal, Canada.

422. Moftakhar P, Cooke DL, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts: "Degree of collateralization predicts symptomatic cerebral vasospasm among pediatric patients: Correlation between angiography, TCD, and clinical findings". 52nd Annual Meeting. American Society of Neuroradiology. May 19-22, 2014. Montreal, Canada.

423. Alexander M, Cooke D, Meyers P, Amans M, Narvid J, Dowd CF, Halbach V, Higashida RT, Hetts S: Demographic and lesion characteristics outperform degree of stenosis in predicting outcomes following stenting for symptomatic intracranial atherosclerosis. 11th Annual Scientific Meeting of the Society of Neuro Interventional Surgery. Colorado Springs, Colorado. July 28- 31, 2014.

424. Hetts S, Tsai T, Cooke D, Amans M, Narvid J, Dowd C, Higashida RT, Halbach: De Novo, Progressive, Multiple, and Recurrent Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. 11th Annual Scientific Meeting of the Society of Neuro Interventional Surgery. Colorado Springs, Colorado. July 28-31, 2014.

427.

Regional Scientific Presentations

177 of 193 Prepared: October 27, 2015

428. "Pulmonary hypertensive response to adenosine diphosphate: Role of prostaglandin's", Higashida RT, Hyman A, Kadowitz P. Pulmonary Section of the Southern Society for Clinical Investigation, New Orleans, LA, January 1978.79

429. "Ophthalmologic complications resulting from treatment of carotid cavernous sinus fistulae", Higashida RT, Halbach VV, Bentson JR, Hieshima GB. Western Neuroradiology Society Annual Meeting, Santa Barbara, CA October 1984.

430. "The hazardous carotid cavernous fistula", Halbach VV, Higashida RT, Bentson JR, Hieshima GB. Western Neuroradiological Society Annual Meeting, Santa Barbara, CA, October 1984.

431. "Unusual treatments for carotid cavernous fistulae", Hieshima GB, Bentson JR, Higashida RT. Western Neuroradiological Society Annual Meeting, Santa Barbara, CA, October 1984.

432. "Magnetic resonance imaging of the orbits and cavernous sinuses", Bentson JR, Higashida RT, Hieshima GB. Western Neuroradiological Society Annual Meeting, Santa Barbara, CA, October 1984.

433. "Digital fluoroscopy in the treatment of intracranial aneurysms with detachable balloons", Reicher M, Hieshima GB, Halbach VV, Higashida RT, Bentson JR. Western Neuroradiological Society Annual Meeting, Monterey, CA, October 1985.

434. "Angioplasty of intracranial arterial vasospasm", Hieshima GB, Higashida RT, Bentson JR, Goto K, Halbach VV, Reicher MA. Western Neuroradiological Society Annual Meeting, Monterey, CA, October 1985.

435. "Combined neuroradiologic/neurosurgical treatment of complex cerebral arteriovenous malformations", Martin NA, Becker DP, Hieshima GB, Higashida RT. Southern California Chapter, American College of Surgeons, Palm Springs, CA, January 1986.

436. "Intravascular balloon embolization therapy for cavernous carotid artery aneurysms", Higashida RT, Hieshima GB, Halbach VV. Federation of Western Societies of Neurological Sciences Annual Meeting, San Francisco, CA, February 1986.

437. "Therapeutic embolization of dural arteriovenous malformations: Techniques, results and complications", Halbach VV, Higashida RT, Hieshima GB, Reicher MA, Madsen PW. Federation of Western Societies of Neurological Sciences, San Francisco, CA, February 1986.

438. "Intra-operative digital angiography", Martin NA, Hieshima GB, Frazee JG, Reicher M, Rand R, Becker D, Higashida RT, Halbach VV. Federation of Western Societies of Neurological Sciences, San Francisco, CA, February 1986.

439. "The morphological effects of balloon dilatation on atherosclerotic cerebral arteries", Saunders M, Martin NA, Vinters H, Frazee JG, Becker DP, Hieshima GB, Higashida RT. Federation of Western Societies of Neurological Sciences, San Francisco, CA, February 1986.

440. "Intravascular embolization of intracranial aneurysms: Indications and techniques", Higashida RT, Hieshima GB, Halbach VV, Dormandy B, Bell J. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

178 of 193 Prepared: October 27, 2015

441. "Unusual presentations and treatment of paragangliomas", Guillaumin B, Hardin C, Hieshima GB, Higashida RT, Halbach VV. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

442. "Efficacy of embolization of nasopharyngeal angiofibromas", Bentson J, Hieshima GB, Higashida RT, Reicher M, Halbach VV, Ward, Calcaterra. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

443. "Treatment of dural fistulas including the cavernous, transverse, and sigmoid sinuses", Halbach VV, Higashida RT, Hieshima GB, Bentson J, Norman D. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

444. "Treatment of large and giant aneurysms of the cavernous carotid artery", Higashida RT, Hieshima GB, Halbach VV. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

445. "PTA of the subclavian, vertebral and basilar artery", Higashida RT, Hieshima GB, Tsai F, Halbach VV. Annual Meeting of the Western Neuroradiological Society, Rancho Mirage, CA, October 1986.

446. "Intravascular detachable balloon embolization therapy for the treatment of intracranial aneurysms: Indications and techniques", Higashida RT, Halbach VV, Hieshima GB. Federation of Western Societies of Neurological Sciences, San Diego, CA, March 1987.

447. "The hazardous carotid cavernous fistula", Halbach VV, Higashida RT, Hieshima GB. Federation of Western Societies of Neurological Sciences, San Diego, CA, March 1987.

448. "Percutaneous transluminal angioplasty techniques for carotid, subclavian, and vertebral artery", Higashida RT, Halbach VV, Tsai RY, Hieshima GB. Federation of Western Societies of Neurological Sciences, San Diego, CA, March 1987.

449. "Platinum wire: A new transvascular embolic agent", Yang P, Halbach VV, Higashida RT, Hieshima GB. Western Neuroradiological Society, Annual Meeting, Scottsdale, AZ, October 8- 10, 1987.

450. "Transvascular treatment of vertebral fistulas", Halbach VV, Higashida RT, Hieshima GB, Yang P, Hardin C. Western Neuroradiological Society, Annual Meeting, Scottsdale, AZ, October 8-10, 1987.

451. "Treatment of intracranial aneurysms by transvascular balloon", Halbach VV, Higashida RT, Hieshima GB, Hardin C, Yang P. Western Neuroradiological Society, Annual Meeting, Scottsdale, AZ, October 8-10, 1987.

452. "Pre Operative balloon embolization of cerebral arteriovenous malformations", Halbach VV, Higashida RT, Hieshima GB, Yang PJ, Hardin C. Western Neuroradiological Society, Annual Meeting, Scottsdale, AZ, October 8-10 1987.

453. "Arteriovenous malformations of the spinal cord: MR spectrum", Dillon WD, Gaensler E, Tsuruda J, Dowd C, Halbach VV, Higashida RT, Hieshima G, Annual Meeting of the Western Neuroradiological Society, Rancho Bernardo, California, October 14-16, 1988.

179 of 193 Prepared: October 27, 2015

454. "Transvenous embolization of dural carotid cavernous sinus fistulae", Halbach VV, Higashida RT, Dowd C, Barnwell S, Hieshima G, Annual Meeting of the Western Neuroradiological Society, Rancho Bernardo, California, October 14-16, 1988.

455. "Transvenous embolization of superior sagital sinus dural fistulae", Halbach VV, Higashida RT, Dowd C, Barnwell S, Hieshima GB. Annual Meeting of the Western Neuroradiological Society, Rancho Bernardo, California, October 14-16, 1988.

456. "Technical aspects of balloon occlusion therapy for treatment of intracranial aneurysms", Higashida RT, Halbach VV, Dowd C, Barnwell S, Hieshima GB. Annual Meeting of the Western Neuroradiological Society, Rancho Bernardo, California, October 14-16, 1988.

457. "Percutaneous transluminal angioplasty of arterial vasospasm using a new silicone microballoon device", Higashida RT, Halbach VV, Dowd C, Barnwell S, Hieshima GB, Annual Meeting of the Western Neuroradiological Society, Rancho Bernardo, California, October 14-16, 1988.

458. "Treatment of petrous carotid aneurysms", Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL. Annual Meeting of the Western Neuroradiological Society, Monterey, California, October 1989.

459. "Transfemoral venous embolization of vein of Galen Malformations", Dowd CF, Halbach VV, Barnwell SL, Higashida RT, Hieshima GB. Annual Meeting of the Western Neuroradiological Society, Monterey, California, October 1989.

460. "Venography and pressure monitoring in dural sinus meningiomas". Halbach VV, Barnwell SL, Higashida RT, Dowd CF, Hieshima GB. Annual Meeting of the Western Neuroradiological Society, Monterey, California, October 1989.

461. "Interventional neurovascular treatment for intracranial aneurysms: Results in 194 cases. Higashida RT, Halbach VV, Dowd C, Barnwell SL, Hieshima GB. Annual Meeting of the Western Neuroradiological Society, Monterey, California, October 1989.

462. "Vascular perforations resulting from neurointerventional procedures." Halbach VV, Higashida RT, Hieshima GB, Dowd CF, Barnwell SL. Annual Meeting of the Western Neuroradiological Society. Santa Fe, New Mexico. October 1990.

463. "Platinum coil embolization of unusual aneurysms". Dowd CF, Halbach VV, Higashida RT, Barnwell SL, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. Santa Fe, New Mexico. October 1990.

464. "Endovascular treatment of intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Barnwell SL, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. Santa Fe, New Mexico. October 1990.

465. "Mid-basilar aneurysms: Treatment by balloon occlusion of the basilar artery." Dowd CF, Halbach VV, Higashida RT, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. Laguna Nigel, California. October 1991.

466. "Treatment of giant intracranial aneurysms with mass effect." Halbach VV, Higashida RT, Dowd CF, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. Laguna Nigel, California. October 1991.

180 of 193 Prepared: October 27, 2015

467. "Treatment of giant perimedullary fistulas." Halbach VV, Higashida RT, Dowd CF, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. Laguna Nigel, California. October 1991.

468. "Endovascular neurosurgical treatment of complex intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Fraser K, Smith T, Teitelbaum G, Hieshima GB. Western Neurosurgical Society. Thirty Sixth Annual Meeting. Vancouver, British Columbia. September 19-22, 1992.

469. "Management options in the treatment of congenital vascular abnormalities in the pediatric population." Edwards ME, Hieshima GB, Halbach VV, Higashida RT. Western Neurosurgical Society. Thirty Sixth Annual Meeting. Vancouver, British Columbia. September 19-22, 1992.

470. "Endovascular therapy for vertebral dissections." Halbach VV, Higashida RT, Dowd CF, Fraser K, Smith T, Teitelbaum G, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. San Francisco, Ca. October 1992.

471. "Evaluation of the electrolytically detachable platinum coil for the treatment of fusiform aneurysms and fistulae.: Halbach VV, Higashida RT, Dowd CF, Fraser K, Smith T, Teitelbaum G, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. San Francisco, Ca. October 1992.

472. "Results of the North American Cerebral Percutaneous Transluminal Angioplasty Register." Higashida RT, Tsai FY, Halbach VV, Dowd CF, Fraser K, Smith T, Teitelbaum G, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. San Francisco, Ca. October 1992.

473. "Simultaneous cavernous sinus venous sampling." Fraser KW, Halbach VV, Smith TP, Dowd CF, Higashida RT, Teitelbaum G, Wilson C, Hieshima GB. Annual Meeting of the Western Neuroradiological Society. San Francisco, Ca. October 1992.

474. "Direct puncture coil embolization of a maxillary arteriovenous malformation and fistula." Teitelbaum G, Halbach VV, Dowd CF, Fraser K, Smith T, Higashida RT, Hieshima G. Annual Meeting of the Western Neuroradiological Society. San Francisco, Ca. October 1992.

475. "Posterior fossa pseudoaneurysm resulting from head and neck tumor biopsy". Teitelbaum GP, Higashida RT, Halbach VV, Dowd CF, Hieshima GB. 25th Annual Meeting of the Western Neuroradiological Society. Pasadena, California. October 7-10, 1993.

476. "Endovascular treatment of mural type vein of Galen malformations." Halbach VV, Higashida RT, Dowd CF, Teitelbaum GP, Hieshima GB. 25th Annual Meeting of the Western Neuroradiological Society. Pasadena, California. October 7-10, 1993.

477. "Endovascular treatment of dysplastic aneurysms associated with intracranial arteriovenous malformations." Teitelbaum GP, Higashida RT, Halbach VV, Dowd CF, Hieshima GB. 25th Annual Meeting of the Western Neuroradiological Society. Pasadena, California. October 7-10, 1993.

478. "Interventional neurovascular treatment of giant intracranial aneurysms." Higashida RT, Halbach VV, Dowd CF, Teitelbaum GP, Hieshima GB. 25th Annual Meeting of the Western Neuroradiological Society. Pasadena, California. October 7-10, 1993.

181 of 193 Prepared: October 27, 2015

479. "Metallic fragment emboli resulting from treatment with electrolytically detachable coils. Halbach VV, Higashida RT, Dowd CF, Hieshima GB. 26th Annual Meeting of the Western Neuroradiological Society. Tucson, Arizona. October 6-9, 1994.

480. "Endovascular treatment of basilar tip aneurysms using electrolytically detachable coils." Halbach VV, Higashida RT, Dowd CF, Hieshima GB. 26th Annual Meeting of the Western Neuroradiological Society. Tucson, Arizona. October 6-9, 1994.

481. "Diagnosis and management of spinal dural arteriovenous fistulas". Larsen D, Halbach VV, Higashida RT, Dowd CF, Hieshima GB. 26th Annual Meeting of the Western Neuroradiological Society. Tucson, Arizona. October 6-9, 1994.

482. "Endovascular aneurysm therapy with electrolytically detachable coils: preliminary experience in 94 patients." Dowd CF, Halbach VV, Higashida, RT, Hieshima GB. 26th Annual Meeting of the Western Neuroradiological Society. Tucson, Arizona. October 6-9, 1994.

483. "Dural arteriovenous fistulas of the marginal sinus." McDougall CG, Halbach VV, Larsen DW, Dowd CF, Higashida RT, Hieshima. 27th Annual Meeting of the Western Neuroradiological Society, October 508, 1995. Victoria, British Columbia, Canada.

484. "Large and giant aneurysms: Endovascular treatment using the GDC system." Dowd CF, Halbach VV, Higashida RT, Larsen DW, Urwin RW, Hieshima GB. . 27th Annual Meeting of the Western Neuroradiological Society, October 5-8, 1995. Victoria, British Columbia, Canada.

485. "Athero-emboli to the Brain: size threshold for causing acute neuronal cell death". Rapp JH, Pan XM, Sharp FR, Shah DM, Wille GA, Velez PM, Higashida RT, Saloner D. Western Vascular Society Meeting, Squaw Creek, Lake Tahoe, California. September 19-22, 1999.

486. Dowd C, Caragine LP, Ng P, Higashida R: "Angioplasty and Stenting for Intracranial Atherosclerotic Disease." Western Neuroradiological Society, Santa Barbara, CA, October 2001

487. Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Dowd CF, Higashida RT, Halbach VV, Lawton M, Kim H. Angioarchitecture of Brain AVMs: Age-Dependent Changes. Western Neuroradiological Society. Kona, Hawaii. October 2013.

RESEARCH PROGRAM

RESEARCH

Approximately 10-15 hours each week is spent in clinical and basic science research.

Currently basic science research is being conducted to study newer, more innovative techniques to treat a variety of neurovascular disorders including cerebral aneurysms, vascular malformations, brain tumors, and arterial vasospasm in animal models and in active clinical

182 of 193 Prepared: October 27, 2015

practice within the interventional neurovascular radiology section.

Dr. Higashida is a member of the UCSF Neurosciences & NeuroImaging service line, which brings together clinicians, basic scientists and post-doctoral fellows, within the Radiology and Biomedical Imaging Department, to coordinate and study various imaging modalities, translational research, and therapeutic treatments. Currently under investigation are the study of computational fluid hemodynamics in cerebral artery aneurysms, longitudinal growth of large and giant aneurysms by magnetic resonance angiography, cerebral blood flow imaging by xenon perfusion imaging, hemorrhagic risk factors in brain arteriovenous malformations, and imaging of hypervascular brain tumors by intra-arterial gadolinium enhancement.

In terms of innovative research and the development of new methods and tools, Dr. Higashida has encouraged his junior faculty to engage in developing new devices and techniques essential to the growing field of minimally invasive neurosurgery and interventional neuroradiology. These developments include the use of intra-arterial chemotherapy infusion for treatment of intra-ocular retinoblastoma in children; the evaluation of radiofrequency heating in endovascular microcatheters; evaluating the feasibility of harvesting endothelial cells using detachable coils; the technical feasibility to perform endovascular biopsy of tissue using capture micro- dissection and fluorescence activated cell sorting; and endovascular biopsy in a rabbit cerebral aneurysm model.

PAST RESEARCH ACCOMPLISHMENTS

Dr. Higashida has had a number of Scientific Research Grants awarded to him as Principal or Co-Principal Investigator. These include:

1. Research Grant to compare the Safety, Tolerance, and Diagnostic Efficacy of Iotrolan 280 mgI/ml and Iohexol 300 mgI/ml in patients requiring Cerebral Angiography. Awarded for (b) (4) Principal Investigator.

2. U.C.S.F. Departmental Research Grant awarded for $30,000.00 for basic science investigation of intravascular stents in an animal model. Principal Investigator.

3. Lawrence Livermore/UCSF Cooperative Research Project for (b) (4) to study endovascular release mechanisms. Principal Investigator.

4. Industry sponsored grant of (b) (4) to coordinate a clinical study to evaluate the clinical efficacy of intra-arterial thrombolysis in acute stroke therapy patients. The PROACT I/II Trial, as

183 of 193 Prepared: October 27, 2015

the National Co-Principal Investigator.

5. CARNEROS I Trial: To study the safety and efficacy of Alfimiprase in acute ischemic stroke, for (b) (4) as the National Principal Investigator.

6. MAVERIC II/III Carotid artery stent with distal protection trial, for (b) (4) , as the National Principal Investigator.

7. The Enterprise Stent for treatment of cerebral artery aneurysms, for(b) (4) as the National Principal Investigator.

8. CONSCIOUS I/II clinical trial to study the safety and dfficacy of a new vasodilatory drug, Clozosentan, for prevention of arterial vasospasm in acute subarachnoid hemorrhage, for (b) (4) as the International Co-Principal Investigator.

SUMMARY OF RESEARCH AND CREATIVE ACTIVITY

Dr. Higashida, as Chief of the Division of Interventional Neurovascular Radiology, has gained a national and international reputation in the field of minimally invasive therapy in interventional neuroradiology and endovascular neurosurgery. He has pioneered many of the techniques, devices, and indications for the treatment of a wide variety of complex neurovascular disorders.

This includes the development, clinical trials, and indications to treat surgically difficult intracranial aneurysms and has resulted in the presentation and publication of a variety of articles. These scientific peer reviewed publications include the following: # 5, 6, 9, 12, 13, 19, 27, 29, 30, 47, 56, 59, 64, 78, 82, 86, 92, 94, 98, 102, 116, 117, 128, 129, 131, 145, 150, 155, 162, 173, 175, 183, 187, 192, 264, and 281.

Dr. Higashida and the INR group have also pioneered many of the techniques for percutaneous transluminal angioplasty and stenting for the carotid artery, subclavian artery, and intracerebral vessels due to atherosclerosis and intracranial vasospasm. These publications include: # 4, 10, 11, 20, 48, 53, 79, 80, 93, 99, 115, 119, 120, 121, 126, 139, 141, 146, 148, 152, 157, 159, 160, 161, 164, 167, 176, 178, 197, 206, 213, 216, 219, 222, 227, 230, 236, 245, and 254.

184 of 193 Prepared: October 27, 2015

Treatment of intracerebral and spinal cord vascular malformations and fistulas by interventional neurovascular techniques have now become the treatment of choice or are used in conjunction with neurosurgical techniques for definitive therapy of these complex lesions. Dr. Higashida and the UCSF interventional neuroradiology group have pioneered and developed many of these techniques and devices. The scientific publications that have resulted from this research include: # 7, 8, 15, 16, 17, 18, 21, 22, 23, 25, 26, 28, 34, 35, 36, 39, 40, 41, 42, 43, 44, 45, 49, 50, 51, 54, 60, 61, 62, 63, 67, 68, 69, 75, 77, 81, 84, 87, 88, 89, 96, 97, 101, 114, 125, 135, 140, 142, 149, 158, 168, 172, 195, 204, 210, 215, 243, 250, 256, 270, 277, 280, 284, and 289.

Working in conjunction with medical device and pharmaceutical companies, Dr. Higashida has pioneered and developed many of the current "state of the art" devices and techniques used in interventional neurovascular procedures. This has resulted in making the treatment of patients safer and more effective in interventional neuroradiology. Scientific publications that reflect these technological breakthroughs include: # 2, 24, 33, 37, 38, 46, 52, 57, 58, 70, 71, 73, 76, 85, 91, 95, 100, 102, 105, 118, 124, 133, 136, 137, 138, 144, 147, 153, 156, 170, 174, 207, 233, 241, and 300.

Dr. Higashida has pioneered many of the indications, devices, drugs and treatments for acute ischemic stroke by interventional therapy. These publications include: # 72, 74, 90, 106, 109, 110, 111, 113, 143, 163, 189, 214, 234, 239, 276, 279, 282, 295, 301, and 302.

Dr. Higashida’s publications in basic science and translational research to evaluate brain tumors, arteriovenous fistulae, cerebral ischemia, modeling of hemodynamic blood flow in complex cerebral artery aneurysms and malformations has also been very extensive, in collaboration with basic scientists and post-doctoral fellows. These have resulted in a number of additional publications including: # 1, 3, 14, 32, 55, 104, 122, 123, 132, 179, 185, 191, 205, 209, 212, 221, 224, 225, 226, 231, 237, 246, 248, 251, 255, 257, 263, 285, 286, 287, 292, 293, and 294.

Dr. Higashida has been involved in a number of national and international clinical trials as the principal and/or co-principal investigator for a number of landmark studies in the field of interventional neuroradiology and acute ischemic and hemorrhagic stroke treatments. These have resulted in a number of significant publications which include: # 107, 108, 127, 130, 134, 151, 154, 177, 188, 190, 193, 194, 198, 200, 201, 202, 217, 218, 220, 228, 229, 232, 238, 240, 242, 247, 249, 252, 253, 258, 259, 260, 265, 271, 272, 274, 275, 283, 290, and 299.

Dr. Higashida has been involved with a number of national and international scientific organizations including the American Heart Association, the American Stroke Association, Society of Neuro Interventional Surgery, the American Society of Neuroradiology, the Joint

185 of 193 Prepared: October 27, 2015

Section of Cerebrovascular Neurosurgery, the American Association of Neurological Surgeons, the Congress of Neurosurgery, the American Acadamy of Neurology, and the U.S. FDA (Food & Drug Administration) to write a number of “standards of practice”, “stroke guidelines”, “imaging guidelines” and “recommendations” papers for hospitals, practicing physicians, and societies in the neurosciences. These publications include: # 165, 166, 171, 180, 181, 182, 184, 186, 196, 199, 203, 208, 211, 223, 235, 244, 261, 262, 266, 267, 268, 269, 273, 278, 288, 291, 296, 294, 298. 303, and 304.

Dr. Higashida’s on-going basic scientific and clinical research areas include the continued study of complex intracranial aneurysms, arterial vasospasm, arteriovenous fistulas and malformations, acute ischemic and hemorrhagic stroke, and intravascular stents.

SUMMARY OF CURRENT RESEARCH PROGRAM

The Interventional Neurovascular Radiology Section is currently involved in a number of clinical and basic science research protocols for which Dr. Higashida is the principal or co-principal investigator, or senior clinical advisor, in conjunction with basic scientists, post-doctoral fellows, medical students, and physician colleagues from the departments of neurosurgery, neurology, anesthesiology, radiology and biomedical engineering.

These research projects include:

1. Evaluation of brain tumors, using MRI/MRA perfusion imaging, for pre-operative assessment of tumor neovascularity.

2. Evaluation of magnetic resonance perfusion imaging for assessment of cerebral ischemia in patients with arterial vasospasm and intracranial atherosclerosis.

3. Serial non-invasive imaging of cerebral arterial aneurysms by longitudinal assessment with quantitative assessment by Magnetic Resonance Imaging and Angiography.

4. Hemodynamic blood flow assessment of large and giant intracranial cerebral artery aneurysms. Evaluation by computational fluid dynamics.

186 of 193 Prepared: October 27, 2015

5. Flow diverters for treatment of inoperable cerebral artery large and giant aneurysms.

6. Carotid artery stenting with distal embolic protection, for treatment of symptomatic and asymptomatic carotid artery atherosclerosis.

7. Blood flow hemodynamics in brain arteriovenous malformations. Parameters that may influence hemorrhage.

8. Endovascular endothelial cell biopsy of cerebral artery aneurysms, by novel intravascular techniques.

9. Intra-arterial Melphalan treatment of pediatric patients with malignant retinoblastoma’s, by direct intra-arterial infusion into the ophthalmic artery for tumor regression.

10. The NIH ARUBA Trial: Evaluation of patients with brain arteriovenous malformations, into a randomized clinical trial to evaluate patient’s prospectively for future incidence of cerebral hemorrhage.

11. Evaluation of vertebral artery dissection as a cause of acute ischemic stroke in the pediatric population, by extension and flexion injury.

12. Evaluation of complex spinal cord vascular abnormalities in the pediatric population.

SIGNIFICANT PUBLICATIONS

1. Higashida RT, Hopkins LN, Berenstein A, Halbach VV, Kerber C, and the American Society of Interventional and Therapeutic Neuroradiology, Joint Section for Cerebrovascular Neurosurgery, Congress of Neurological Surgeons, American Association of Neurological Surgeons, American Society of Neuroradiology: Program Requirements for Residency/Fellowship Education in Neuroendovascular Surgery/Interventional Neuroradiology. American Journal of Neuroradiology. Volume 21, Pages 1153-1159. 2000.

Dr. Higashida provided substantial contributions to conception and design of this study; acquisition of data, analysis, and interpretation of the data; drafting of the article; revisions of the article for intellectual content; and for final approval of the version to be published.

187 of 193 Prepared: October 27, 2015

Dr. Higashida brought together a collaboration of 5 major societies including the American Society of Interventional and Therapeutic Neuroradiology, the Joint Section of Cerebrovascular Neurosurgery, the American Association of Neurological Surgeon, the Congress of Neurological Surgery, and the American Society of Neuroradiology, to agree on a concensus document, which specifies the training requirements of a formalized one year training program, in the field of interventional neuroradiology/endovascular neurosurgery.

This document has formed the basis for adopting these training standard guidelines nationally in the United States and Canada, and worldwide in training programs in Europe, Asia, and South America.

In 2001-2002, these training standards were also adopted by the Accreditation Council for Graduate Medical Education (ACGME), which formalized the field of Interventional Neuroradiology/Endovascular Neurosurgery into a formal accredited ACGME program, and established this field as a new subspecialty in medicine.

2. Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D, for the Technology Assessment Committees of the American Society of Interventional and Therapeutic Neuroradiology and the Society of Interventional Radiology. Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke. Stroke, 2003: Volume 34. Pages 1923-1924. and Stroke 2003; 34:e109-e137. and the Journal of Vascular and Interventional Radiology 2003; 14:945-946.

Dr. Higashida provided substantial contributions to conception and design of this study; acquisition of data, analysis, and interpretation of the data; drafting of the article; revisions of the article for intellectual content; and for final approval of the version to be published.

Dr Higashida published the first document in the field of "reporting standards and guidelines" for designing trials in intra-arterial therapies for patients presenting with an acute ischemic stroke. Dr. Higashida was a consultant to the U.S. FDA and representative for multiple societies including the Society of Interventional and Therpeutic Neuroradiology (ASITN), Joint Section of Cerebrovascular Neurosurgery, the Society of Interventional Radiology, and the American Association of Neurology, in which agreed to standards for designing interventional trials in stroke could be standardized.

This document has served as the basis for trial design and reporting of many major ongoing interventional trials involving stroke patients throughout the U.S. and internationally.

3. Higashida RT, Cognard C, Bracard S: Initial clinical experience with a new complex- shaped detachable platinum coil system for the treatment of intracranial cerebral aneurysms: The Cordis Trufill DCS Detachable Coil System. Interventional Neuroradiology. Volume 12, Number 2, Page 123-130. 2006.

Dr. Higashida provided substantial contributions to conception and design of this study; acquisition of data, analysis, and interpretation of the data; drafting of the article; revisions of the article for intellectual content; and for final approval of the version to be published.

Dr. Higashida was the national and international Principal Investigator for this study, which evaluated the initial and long term clinical outcomes of a new detachable coil system for the treatment of patients who presented with an acutely ruptured or unruptured cerebral artery aneurysm.

188 of 193 Prepared: October 27, 2015

This study was a 2 year trial which involved 112 patients with 116 cerebral aneurysms, treated with the new Cordis Detachable Coil system, and involved 23 medical centers internationally. This study demonstrated that this new coil was safe, effective, and had long term durable results, with excellent patient treatment outcomes, and has become one of the coils now used worldwide to treat patients by these minimally invasive techniques.

4. Higashida RT, Lahue B, Torbey MT, Hopkins LN, Leip E, Hanley DF: Treatment of unruptured intracranial aneurysms. A nationwide assessment of effectiveness. American Journal of Neuroradiology. Volume 28. Pages 146-151. 2007.

Dr. Higashida provided substantial contributions to conception and design of this study; acquisition of data, analysis, and interpretation of the data; drafting of the article; revisions of the article for intellectual content; and for final approval of the version to be published.

This was a retrospective analysis cohort study, using data collected over a 1 year time interval, from 429 hospitals, in 18 states, and representing 58% of the US population. A total of 2535 patient records were evaluated, for treatment by endovascular coiling vs. surgical clipping for an unruptured cerebral artery aneurysm.

Outcome measures included mortality (in-hospital death), adverse outcomes (death or discharge to a rehabilitation or nursing facility), length of stay, and hospital charges. Univariate analysis compared endovascular versus neurosurgical discharge outcomes.

Endovascular treatment was associated with fewer adverse outcomes, decreased mortality, shorter lengths of stay, and lower hospital charges, compared with neurosurgical treatment.

This study indicated that endovascular therapy vs. open neurosurgical clipping should be offered as a viable therapeutic option in all patients undergoing treatment of an unruptured cerebral artery aneurysm, and has been instrumental worldwide in shifting the standard of care from open neurosurgery to interventional treatment, as the therapy of choice.

5. Higashida RT, Popma JJ, Apruzzese P, Zimetbaum P, Maveric I and II Investigators: Evaluation of the Medtronic Exponent Self-Expanding Carotid Stent System With the Medtronic Guardwire Temporary Occlusion and Aspiration System in the Treatment of Carotid Stenosis. Combined from the Maveric (Medtronic AVE Self-expanding CaRotid Stent System with distal protection In the treatment of Carotid Stenosis) I and Maveric II Trials. Stroke 2009. December 28, 2009. Online at: http://stroke.ahajournals.org. Issn: Online: 1524-4628. Print Issn: 0039-2499.

Dr. Higashida provided substantial contributions to conception and design of this study; acquisition of data, analysis, and interpretation of the data; drafting of the article; revisions of the article for intellectual content; and for final approval of the version to be published.

Dr. Higashida served as the National Principal Investigator for this Phase II/III clinical trial. A total of 498 patients were enrolled between 2001-2004, from 40 sites, and followed for long term outcomes at 1 year. The patients were treated with a newly developed carotid artery stent combined with a novel distal embolic protection device, for patients judged to be at "high surgical risk" for carotid endarterectomy, who presented with a symptomatic or high grade asymptomatic carotid artery stenosis.

The 1 year adverse event rate, which was defined as death, stroke, or myocardial infarction was 12.5%, and the incidence of neurologic death was 1.1%. This study demonstrated that the peri-

189 of 193

Prepared: October 27, 2015

In 2001, Dr. Higashida published a concensus document on "training standards for INR physicians", in collaboration with the five major societies representing this specialty. Shortly thereafter, these standards were adopted by the ACGME, and became formalized into post- graduate studies for fellowship training after completion of residency in either radiology, neurosurgery, or neurology. This document has also been used to establish training standards worldwide in Europe, Asia, and South America, and the INR field has since become officially recognized as a separate subspecialty, within the neurosciences, requiring formal post-graduate training and standards of practice.

Dr. Higashida has been extremely active in developing this field. He is the Past President of the Society of Neuro Interventional Surgery (SNIS), the national organization representing INR specialists. He was on the executive committee of the Joint Section of Cerebrovascular Neurosurgery for 10 years. He is a senior member of the American Society of Neuroradiology (ASNR), and served on the executive committee, was the chair of the education committee, and served on the intersociety liaison committee, rules committee, coding and reimbursement committee, and programing committee.

Dr. Higashida was actively involved with the American Heart Association (AHA) and the American Stroke Association (ASA). He has served as Chair of the Cardiovascular Radiology and Interventions Council, executive committee of the AHA scientific council, Chair of the Neuroradiology committee, and has served on over twelve writing groups of the AHA/ASA to develop standards, guidelines, and policies for hospitals and physicians, regarding evaluation, management, and treatment of hemorrhagic and ischemic stroke patients.

Dr. Higashida has been a consultant to the U.S. FDA for 21 years, interacting with both the Biological Division and the Medical Devices Division, advising them on policies regarding new drugs and devices for use in neurological procedures. He currently is a physician panelist and reviewer for the FDA Neurological Devices division.

Dr. Higashida has also been a consultant for the National Institutes of Health - Neurological Disorder and Stroke Division (NINDS), providing input on clinical trials and development of stroke protocols. He has served on the NINDS Data Safety and Monitoring Board of the CREST (Carotid Revascularization by Endarterectomy vs Stenting Trial) study, which required monitoring of this $40M funded study, and 10 years of review. This trial ultimately demonstrated that carotid artery stenting was equivalent to carotid artery surgery for the treatment of cervical atherosclerosis, the number two most frequent vascular surgical procedure in the U.S. after .

Over the past 28 years, Dr. Higashida and the INR group have pioneered the interventional treatment of ruptured and unruptured cerebral artery aneurysms by detachable coil treatment; acute ischemic stroke therapy by intra-arterial thrombolysis and clot removal; treatment of arterial vasospasm by balloon angioplasty; devascularization of tumors of the head, neck, and

191 of 193 Prepared: October 27, 2015 spine for pre-surgical removal; treatment of cerebral arteriovenous malformations (AVM's) and arteriovenous fistula's (AVF's); treatment of carotid artery atherosclerosis by stenting; and the diagnosis and treatment of complex spinal cord lesions.

Dr. Higashida has travelled worldwide to give lectures, teach these techniques, treat patients, and train other physicians in radiology, neurosurgery, and neurology on how to correctly perform these procedures. Currently, the UCSF INR service is one of the busiest and most active centers in the U.S., performing >1200 procedures per year, on patients referred from across the U.S. and worldwide .

Dr. Higashida is recognized nationally and internationally as one of the leaders and pioneering INR physicians in this field. He has presented at more than 470 conferences and given over 800 lectures throughout the U.S. and worldwide on these procedures and techniques. Dr. Higashida has published more than 300 peer reviewed scientific articles, written more than 120 book chapters, co-authored 4 books, and has been a Distinguished Visiting Professor at more than 90 medical centers and teaching institutions worldwide.

The INR division, has helped to establish UCSF as one of the worldwide leaders in the neurosciences, in pioneering research, leading clinical trials, academic teaching, and above all excellent care for patients with complex cerebrovascular disorders.

Summary of Academic Accomplishments

Peer Reviewed Scientific Papers: 332

• Published: 313 (b) • In-Press/Submitted: (4)

Chapters in Medical Textbooks: 125

192 of 193 Prepared: October 27, 2015

Textbooks Published: 4

Service to Professional Publications: 30 (Including 18 Editorial Boards of Scientific Journals)

Invited Presentations:

• International: 189 • National: 176 • Regional: 109 • Total: 474

Scientific Poster Presentations:

• International: 33 • National: 51 • Total: 84

Scientific Presentations at Meetings (includes presentations by other authors)

• International: 143 • National: 182 • Regional: 60 • Total: 385

193 of 193