Louisiana Opioid Epidemic Town Hall Series
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The Opioid Epidemic: What Labs Have to Do with It?
The Opioid Epidemic: What labs have to do with it? Ewa King, Ph.D. Associate Director of Health RIDOH State Health Laboratories Analysis. Answers. Action. www.aphl.org Overview • Overdose trends • Opioids and their effects • Analytical testing approaches • Toxicology laboratories Analysis. Answers. Action. www.aphl.org Opioid overdose crisis 1 Analysis. Answers. Action. www.aphl.org Opioid overdose crisis 2 Analysis. Answers. Action. www.aphl.org Opiates and Opioids • Opiates vs. Opioids • Opiates: Naturally occurring, derived from the poppy plant • Opioids: “Opiate-like” drugs in effects, not chemical structure Includes opiates • Narcotic analgesics • CNS depressants • DEA Schedule I or II controlled substances • Additive effect with other CNS depressant drugs Analysis. Answers. Action. www.aphl.org Efficacy of Opioids • How do opioids work? • Bind with opioid receptors • Brain, spinal cord, GI tract, and throughout the body • Pain, emotion, breathing, movement, and digestion Opioid Receptor Analysis. Answers. Action. www.aphl.org Effects of Opioids Physiological Psychological • Pain relief • Drowsiness/ sedation • Cough suppression • Mental confusion • GI motility • Loss of memory • Respiratory depression • Lethargy/ apathy • Pupillary constriction • Euphoria/ tranquility • Itching • Mood swings • Constipation • Depression • Dependence • Withdrawal • Dependence Analysis. Answers. Action. www.aphl.org Opiates 1 Opiates • Naturally occurring alkaloids Opium • Latex from the opium poppy plant Codeine: • Mild to moderate pain • Antitussive Morphine: • Severe pain • Metabolite of codeine and heroin Analysis. Answers. Action. www.aphl.org Opiates 2 Semi-synthetic Opiates: • Synthesized from a natural opiate Heroin: • Schedule I narcotic Hydrocodone (Vicodin): • Mild to moderate pain • Metabolizes to hydromorphone (Dilaudid) Oxycodone (Oxycontin/Percocet): • Moderate to severe pain • Metabolizes to oxymorphone (Opana) Analysis. Answers. Action. -
A Review of Unique Opioids and Their Conversions
A Review of Unique Opioids and Their Conversions Jacqueline Cleary, PharmD, BCACP Assistant Professor Albany College of Pharmacy and Health Sciences Adjunct Professor SAGE College of Nursing DISCLOSURES • Kaleo • Remitigate, LLC OBJECTIVES • Compare and contrast unique pharmacotherapy options for the treatment of chronic pain including: methadone, buprenoprhine, tapentadol, and tramadol • Select methadone, buprenorphine, tapentadol, or tramadol based on patient specific factors • Apply appropriate opioid conversion strategies to unique opioids • Understand opioid overdose risk surrounding opioid conversions and the use of unique opioids UNIQUE OPIOIDS METHADONE, BUPRENORPHINE, TRAMADOL, TAPENTADOL METHADONE My favorite drug because….? METHADONE- INDICATIONS • FDA labeled indications – (1) chronic pain (2) detoxification Oral soluble tablets for suspension NOT indicated for chronic pain treatment • Initial inpatient detoxification of opioids by a licensed trained provider with methadone and supportive care is appropriate • Methadone maintenance provider must have special credentialing and training as required by state Outpatient prescription must be for pain ONLY and say “for pain” on RX • Continuation of methadone maintenance from outside provider while patient is inpatient for another condition is appropriate http://cdn.atforum.com/wp-content/uploads/SAMHSA-2015-Guidelines-for-OTPs.pdf MECHANISM OF ACTION • Potent µ-opioid agonist • NMDA receptor antagonist • Norepinephrine reuptake inhibitor • Serotonin reuptake inhibitor ADVERSE EVENTS -
Recommended Methods for the Identification and Analysis of Fentanyl and Its Analogues in Biological Specimens
Recommended methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2017 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/53 Original language: English © United Nations, November 2017. All rights reserved. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. Barry Logan, Center for Forensic Science Research and Education, at the Fredric Rieders Family Founda- tion and NMS Labs, United States; Amanda L.A. -
Opioid & Other Drug Overdose Syndromic Surveillance Report
Opioid & Other Drug Overdose Syndromic Surveillance Report Suspected Unintentional Overdose Visits Past 14 Weeks Week Starting # of Visits 7-Week Ave. Alerts (1-Week Lag) 6/20/21 32 33.0 None 6/27/21 39 33.4 None 7/4/21 27 36.0 None 7/11/21 35 35.1 None 7/18/21 31 35.9 None 7/25/21 38 34.6 None 8/1/21 26 33.7 None 8/8/21 37 32.6 None 8/15/21 30 33.3 None 8/22/21 31 32.0 None 8/29/21 24 32.6 None 9/5/21 33 31.0 None 9/12/21 22 31.3 None 9/19/21 26 29.0 None Date report produced: 27-Sep-2021 Notes. Includes all patients 10 years and older visiting ALL Simcoe Muskoka Hospitals. Opioid and/or Toxicity related visits with a CTAS score of 1, 2, 3 or missing. Alerts are generated using the CDC EARS CUSUM Algorithm. C1 uses a 7-Week baseline with a one-Week lag. Participating Hospitals. Muskoka Algonquin Healthcare – Bracebridge (BRSH) & Muskoka Algonquin Healthcare – Huntsville (HUSH); Georgian Bay General Hospital (GBGH) & Orillia Soldiers Memorial Hospital (OSMH); Royal Victoria Regional Health Centre (RVH); Stevenson Memorial Hospital (SVMH); Collingwood General and Marine Hospital (CGMH). Data Source. Acute Care Enhanced Surveillance (ACES): a real-time syndromic surveillance system developed and maintained by Kingston, Frontenac and Lennox and Addington (KFL&A) Public Health and funded by the Ministry of Health and Long Term Care (http://www.kflaphi.ca/acute-care-enhanced-surveillance/). -
Defining Clinical Issues Around Tolerance, Hyperalgesia, And
ORIGINAL ARTICLE Defining clinical issues around tolerance, hyperalgesia, and addiction: A quantitative and qualitative outcome study of long-term opioid dosing in a chronic pain practice Jennifer P. Schneider, MD, PhD; Kenneth L. Kirsh, PhD ARTICLE INFO ABSTRACT Keywords: Treatment with opioid medications has grown over the past decades, but has been tolerance surrounded by some ongoing controversy and debate to whether it is causing more dependence opioids harm than good for patients. To this end, the field of pain management has suf- hyperalgesia fered from a lack of clarity about some basic definitions on concepts such as toler- long-term opioid therapy ance and hyperalgesia. Some characterize these issues as inevitable parts of opioid therapy while other schools of thought look at these issues as relatively rare occur- Article history: rences. Unfortunately, most of the rhetoric around these topics has occurred with Received 13 February 2010 very little in the realm of real world data. To this end, the authors have reviewed Received in revised form 26 July 2010; the charts of 197 patients treated by a pain specialist for at least 1 year to better 30 August 2010 Accepted 31 August 2010 illustrate whether notions of tolerance and hyperalgesia are common occurrences DOI:10.5055/jom.2010.0036 and, more importantly, whether they occur within any type of specified timeframe. A total of 197 patient charts were reviewed. The sample had an average age of 49.39 years (range ϭ 19-87 years; standard deviation [SD] ϭ 12.48) and com- prised 66 men (33.5 percent) and 131 women (66.5 percent). -
SAMHSA Opioid Overdose Prevention TOOLKIT
SAMHSA Opioid Overdose Prevention TOOLKIT Opioid Use Disorder Facts Five Essential Steps for First Responders Information for Prescribers Safety Advice for Patients & Family Members Recovering From Opioid Overdose TABLE OF CONTENTS SAMHSA Opioid Overdose Prevention Toolkit Opioid Use Disorder Facts.................................................................................................................. 1 Scope of the Problem....................................................................................................................... 1 Strategies to Prevent Overdose Deaths.......................................................................................... 2 Resources for Communities............................................................................................................. 4 Five Essential Steps for First Responders ........................................................................................ 5 Step 1: Evaluate for Signs of Opioid Overdose ................................................................................ 5 Step 2: Call 911 for Help .................................................................................................................. 5 Step 3: Administer Naloxone ............................................................................................................ 6 Step 4: Support the Person’s Breathing ........................................................................................... 7 Step 5: Monitor the Person’s Response .......................................................................................... -
Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics
December 6, 2000 NIDA-CTN-0007 MOTIVATIONAL INCENTIVES FOR ENHANCED DRUG ABUSE RECOVERY: METHADONE CLINICS Maxine Stitzer, Ph.D., Lead Investigator Nancy Petry, Ph.D. Co-Lead Investigator Robert Brooner, Ph.D. Co-Investigator Jessica Peirce, Project Coordinator Protocol work group: Nancy Petry New England Paul McLaughlin New England Richard Rawson Pacific Frank Flammino Pacific Bob Forman Delaware Valley Peter Barbur Northwest Sara Lamb Northwest Scott Kellogg New York Elaine Pencer New York Jack Blaine NIDA NIDA-CTN-0007 Motivational Incentives: Methadone Clinic 1 Version 6, Date December 6, 2000 December 6, 2000 TABLE OF CONTENTS 1 LIST OF ABBREVIATIONS................................................................................................. 3 2 PROTOCOL SUMMARY...................................................................................................... 4 3 BACKGROUND AND SIGNIFICANCE.............................................................................. 7 4 STUDY OBJECTIVE........................................................................................................... 10 5 SUSTAINABILITY WITHIN THE CTP’S ........................................................................ 10 6 STUDY DESIGN.................................................................................................................. 11 6.1 Drug targets....................................................................................................................... 11 6.2 Bonus incentive targets: opiates....................................................................................... -
Collision of COVID-19 on Opioid Overdose and Treatment
Emerging Issues in the Opioid Crisis Nora D. Volkow, M.D. Director National Institute on Drug Abuse @NIDAnews Overdose Deaths in 2019 Increased by 4.6% Number of Deaths Number of Deaths 40,000 Fentanyl, 37,137 18,000 Prescription opioids, 14,347 Methamphetamine, 16,539 35,000 16,000 Heroin, 14,278 Cocaine, 16,196 30,000 14,000 12,000 25,000 10,000 20,000 8,000 15,000 6,000 10,000 4,000 5,000 2,000 0 0 Overdose Death Rates: Other Synthetic Narcotics (Including Illicit Fentanyl) 2013 2018 Source: CDC WONDER. Age-adjusted death rates per 100,000. Overdose Death Rates: Psychostimulants With Abuse Potential (Including Methamphetamine) 2013 2018 Source: CDC WONDER. Age-adjusted death rates per 100,000. Intersection Between Opioid Crisis and COVID-19 ` Overdoses Grew Dramatically During COVID Pandemic ST Drug Use Increase During COVID Total US Increase 31.96% 19.96% 10.06% 12.52% 7 Millennium Health Signals Report™ COVID-19 Special Edition: Significant Changes in Drug Use During the Pandemic Volume 2.1 | Published July 2020 Total Study Population Change in Unadjusted Positivity Rate for Cocaine, Fentanyl, Heroin and Methamphetamine COVID-Related Policy Changes for Prescribing Medications for OUD Methadone Buprenorphine Prior to COVID: Prior to COVID: • Only federally-approved opioid • Prescribed through pharmacies in outpatient treatment programs settings • In-person for daily dosing • DATA 2000, limited to clinicians with bup. waivers that required additional training and Under COVID, SAMSHA allowed: federal registration • 3/16/2020: 28 day -
Appendix 1 – Data Code Values
Florida Department of Children and Families Substance Abuse and Mental Health Financial and Services Accountability Management System (FASAMS) Pamphlet 155-2 Appendix 1 Data Code Values Last Revision Date: 10/01/2021 Effective Date: 7/01/2021 Version 14.0 Pamphlet 155-2 Appendix 1, Version 14.0 Last Revision Date 10/01/2021 Effective Date: 7/01/2021 Page 1 of 64 Table of Contents 1 State/Province ................................................................................................................................................................ 3 2 County Area .................................................................................................................................................................... 4 3 Covered Service .............................................................................................................................................................. 5 4 Service Category ............................................................................................................................................................. 9 5 Project Codes .................................................................................................................................................................. 9 6 Project Codes, Method of Payment and Unit of Measure ........................................................................................... 13 7 FY 2021-22 Active OCA Codes ...................................................................................................................................... -
Wisconsin Opioid Treatment Program Patient Reference Handbook
WISCONSIN Opioid Treatment Program PATIENT REFERENCE HANDBOOK Department of Health Services Division of Care and Treatment Services Bureau of Prevention Treatment and Recovery P-23048 (09/2016) WELCOME Congratulations on taking the first step into treatment and long-term recovery from your addiction! At this point, you may be unsure of how treatment works and what to expect. This book is designed to provide you and your loved ones answers to questions you may have concerning treatment. Please note that this book is a reference tool to use. If you have questions after reading this handbook, please make sure to ask a staff person. The information that is provided in this handbook should be seen as guidelines for narcotic treatment clients. This handbook provides guidance of often difficult to understand state and federal regulations. Further, this guidance should not be construed as providing rigid answers, except in those areas where state or federal laws exist. Please refer to individual clinic policies and procedures if you have questions or are unsure of the rules when it comes to medication-assisted treatment. Life is very interesting...in the end, some of your greatest pains become your greatest strengths. Drew Barrymore Quote for Overcoming Addiction Wisconsin Department of Health Services Division of Care and Treatment Services Bureau of Prevention Treatment and Recovery State Opioid Treatment Authority 1 West Wilson Street Room 850 Madison WI 53703 October 2011 Revised September 2016 OPIOID TREATMENT SERVICE – PATIENT REFERENCE -
Lethal Fentanyl & Carfentanil Exposure
San Diego County Sheriff Training Bulletin William D. Gore, Sheriff August 2019 LETHAL FENTANYL & CARFENTANIL EXPOSURE Warning There is a significant threat to law enforcement personnel and other first responders, who may come in contact with fentanyl and other fentanyl-related substances through routine law enforcement, emergency or life-saving activities. Fentanyl and related substances are designed to be absorbed into the body by several means, including injection, oral ingestion, nose or mouth inhalation, or absorbed through the skin or eyes. Any substance suspected to contain fentanyl should be treated with extreme caution; exposure to a small amount can lead to significant health-related complications, such as respiratory failure, or death. What is Fentanyl and Carfentanil? Pharmaceutical grade fentanyl was originally developed legally to provide opioid pain management. Since then, synthetic fentanyl being smuggled in from Mexico and China has been used to create counterfeit pharmaceutical tablets such as oxycodone. Synthetic Fentanyl is also being used as replacement for heroin. Fentanyl is 80-100 times stronger than morphine and many times that of heroin. It would only take two to three milligrams of fentanyl (equivalent to five to seven grains of table salt) to induce respiratory failure and possibly death (see photograph below). Carfentanil is a fentanyl related compound commonly used as a tranquilizing agent for elephants and other large mammals. Carfentanil is 100 times more potent than fentanyl, the high potency and high profit margins of illicit produced fentanyl products are causing the alarming and growing overdose rate. Fentanyl-related substances have been identified in: • Powder (often resembling heroin & cocaine) • Pill • Capsule • Liquid • Blotter paper *Two milligrams of fentanyl; LETHAL dose for most people. -
NIDA Drug Supply Program Catalog, 25Th Edition
RESEARCH RESOURCES DRUG SUPPLY PROGRAM CATALOG 25TH EDITION MAY 2016 CHEMISTRY AND PHARMACEUTICS BRANCH DIVISION OF THERAPEUTICS AND MEDICAL CONSEQUENCES NATIONAL INSTITUTE ON DRUG ABUSE NATIONAL INSTITUTES OF HEALTH DEPARTMENT OF HEALTH AND HUMAN SERVICES 6001 EXECUTIVE BOULEVARD ROCKVILLE, MARYLAND 20852 160524 On the cover: CPK rendering of nalfurafine. TABLE OF CONTENTS A. Introduction ................................................................................................1 B. NIDA Drug Supply Program (DSP) Ordering Guidelines ..........................3 C. Drug Request Checklist .............................................................................8 D. Sample DEA Order Form 222 ....................................................................9 E. Supply & Analysis of Standard Solutions of Δ9-THC ..............................10 F. Alternate Sources for Peptides ...............................................................11 G. Instructions for Analytical Services .........................................................12 H. X-Ray Diffraction Analysis of Compounds .............................................13 I. Nicotine Research Cigarettes Drug Supply Program .............................16 J. Ordering Guidelines for Nicotine Research Cigarettes (NRCs)..............18 K. Ordering Guidelines for Marijuana and Marijuana Cigarettes ................21 L. Important Addresses, Telephone & Fax Numbers ..................................24 M. Available Drugs, Compounds, and Dosage Forms ..............................25