Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use. This chapter was originally published in the book International Review of Neurobiology, Vol. 107 published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non- commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who know you, and providing a copy to your institution’s administrator. All other uses, reproduction and distribution, including without limitation commercial reprints, selling or licensing copies or access, or posting on open internet sites, your personal or institution’s website or repository, are prohibited. For exceptions, permission may be sought for such use through Elsevier's permissions site at: http://www.elsevier.com/locate/permissionusematerial From: Charles W. Lu, Parag G. Patil and Cynthia A. Chestek, Current Challenges to the Clinical Translation of Brain Machine Interface Technology. In Clement Hamani and Elena Moro, editors: International Review of Neurobiology, Vol. 107, Burlington: Academic Press, 2012, pp. 137-160. ISBN: 978-0-12-404706-8 © Copyright 2012 Elsevier Inc. Academic Press Author's personal copy CHAPTER SEVEN Current Challenges to the Clinical Translation of Brain Machine Interface Technology Charles W. Lu*, Parag G. Patil*,†,1, Cynthia A. Chestek* *Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA †Department of Neurosurgery, University of Michigan Health System, Ann Arbor, Michigan, USA 1Corresponding author: e-mail address:
[email protected] Contents 1. Introduction and Motivation 137 2.