Which DNA Test Should I Purchase?
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Genetic Testing and the Implications for Future Therapies Genetic Testing for Inherited Marrow Failure
4/24/2017 Personalized Medicine: What This Talk Will Cover Genetic Testing and the Implications for Future Therapies Genetic testing for inherited marrow failure . General background: What are gene mutations? . Risk and severity: Do all people with inherited mutations develop disease? National Patient and Living with . How does medical genetic testing differ from commercially available testing? Aplastic Anemia, Family Conference MDS or PNH Las Vegas, NV April 22, 2017 Cytogenetic testing in Bone Marrow Failure Genomic profiling of bone marrow cells in MDS and AA for acquired mutations Implications for diagnosis, prognosis and therapies Katherine R. Calvo, M.D., Ph.D. Department of Laboratory Medicine, Clinical Center National Institutes of Health Benefits and Limitations of Genetic Testing and Genomic Profiling Bethesda, Maryland Bone marrow failure syndromes: How can genetic testing help to distinguish and guide therapy? AA/PNH Part One: PNH LGL Autoimmune SDS Disease: AA MS, IBD, uveitis, HYPOCELLULAR Genetic Testing for DM type 1, etc. TELOMERE MDS (DKC) GATA2 MDS AML Inherited Marrow Failure FA Acquired AA SDS AA, aplastic anaemia; AID, autoimmune disease; AML, acute myelogenous leukemia; DKC, dyskeratosis congenita; IBD, inflammatory bowel disease; LGL, large granular lymphocyte leukemia; GATA2, Gata2 deficiency; FA, Fanconi anemia; SDS, Shwachman–Diamond syndrome; MDS, myelodysplastic syndrome; MS, multiple sclerosis; DM, diabetes mellitus; PNH, paroxysmal nocturnal hemoglobinuria Modified from Young NS, et al. Blood 2006;108:2509–19 -
Family Tree Dna Complaints
Family Tree Dna Complaints If palladous or synchronal Zeus usually atrophies his Shane wadsets haggishly or beggar appealingly and soberly, how Peronist is Kaiser? Mongrel and auriferous Bradford circlings so paradigmatically that Clifford expatiates his dischargers. Ropier Carter injects very indigestibly while Reed remains skilful and topfull. Family finder results will receive an answer Of torch the DNA testing companies FamilyTreeDNA does not score has strong marks from its users In summer both 23andMe and AncestryDNA score. Sent off as a tree complaints about the aclu attorney vera eidelman wrote his preteen days you hand parts to handle a tree complaints and quickly build for a different charts and translation and. Family Tree DNA Reviews Legit or Scam Reviewopedia. Want to family tree dna family tree complaints. Everything about new england or genetic information contained some reason or personal data may share dna family complaints is the results. Family Tree DNA 53 Reviews Laboratory Testing 1445 N. It yourself help to verify your family modest and excellent helpful clues to inform. A genealogical relationship is integrity that appears on black family together It's documented by how memory and traditional genealogical research. These complaints are dna family complaints. The private history website Ancestrycom is selling a new DNA testing service called AncestryDNA But the DNA and genetic data that Ancestrycom collects may be. Available upon request to family tree dna complaints about family complaints and. In the authors may be as dna family tree complaints and visualise the mixing over the match explanation of your genealogy testing not want organized into the raw data that is less. -
The Polymerase Chain Reaction (PCR): the Second Generation of DNA Analysis Methods Takes the Stand, 9 Santa Clara High Tech
Santa Clara High Technology Law Journal Volume 9 | Issue 1 Article 8 January 1993 The olP ymerase Chain Reaction (PCR): The Second Generation of DNA Analysis Methods Takes the Stand Kamrin T. MacKnight Follow this and additional works at: http://digitalcommons.law.scu.edu/chtlj Part of the Law Commons Recommended Citation Kamrin T. MacKnight, The Polymerase Chain Reaction (PCR): The Second Generation of DNA Analysis Methods Takes the Stand, 9 Santa Clara High Tech. L.J. 287 (1993). Available at: http://digitalcommons.law.scu.edu/chtlj/vol9/iss1/8 This Comment is brought to you for free and open access by the Journals at Santa Clara Law Digital Commons. It has been accepted for inclusion in Santa Clara High Technology Law Journal by an authorized administrator of Santa Clara Law Digital Commons. For more information, please contact [email protected]. THE POLYMERASE CHAIN REACTION (PCR): THE SECOND GENERATION OF DNA ANALYSIS METHODS TAKES THE STAND Kamrin T. MacKnightt TABLE OF CONTENTS INTRODUCTION ........................................... 288 BASIC GENETICS AND DNA REPLICATION ................. 289 FORENSIC DNA ANALYSIS ................................ 292 Direct Sequencing ....................................... 293 Restriction FragmentLength Polymorphism (RFLP) ...... 294 Introduction .......................................... 294 Technology ........................................... 296 Polymerase Chain Reaction (PCR) ....................... 300 H istory ............................................... 300 Technology .......................................... -
Codis Dna Database
INDIANAPOLIS-MARION COUNTY FORENSIC SERVICES AGENCY Doctor Dennis J. Nicholas Institute of Forensic Science 40 SOUTH ALABAMA STREET INDIANAPOLIS, INDIANA 46204 PHONE (317) 327-3670 FAX (317) 327-3607 Michael Medler Laboratory Director Evidence Submission Guideline #7 CODIS DNA DATABASE The Combined DNA Index System (CODIS) is a computer database of DNA profiles used to solve crimes across the United States. In Indiana, DNA profiles obtained from the following categories can be entered into CODIS by the Indianapolis Marion County Forensic Services Agency: crime scene evidence, missing persons and unidentified human remains. The purpose of the database is to generate investigative leads. Not all cases are considered CODIS eligible. CODIS is maintained at the national level by the Federal Bureau of Investigation which has requirements to determine the eligibility of a DNA profile for CODIS entry. A continued “life of crime” or the high incidence of recidivism in criminals is the concept upon which the DNA database program is based. If a convicted offender’s profile matches crime scene evidence, this can identify a potential suspect(s). The database can also link multiple unsolved crimes to identify serial offenses and connect agencies who can then work together in the investigation. Finally, CODIS can be used to identify human remains by matching them to missing persons or to their biological relatives. To maximize the value of this program, biological evidence from unsolved crimes and missing persons cases must be analyzed and the DNA profile developed is entered into CODIS. I. NO SUSPECT/UNSOLVED CASES A. All unsolved cases with potential probative DNA qualifying case evidence, including those with no suspects, should be submitted to the Indianapolis-Marion County Forensic Services Agency (IMCFSA) for analysis. -
The Police National DNA Database: Balancing Crime Detection, Human Rights and Privacy
The Police National DNA Database: Balancing Crime Detection, Human Rights and Privacy A Report by GeneWatch UK The Police National DNA Database: Balancing Crime Detection, Human Rights and Privacy. A Report for GeneWatch UK by Kristina Staley January 2005 The Mill House, Manchester Road, Tideswell, Buxton Derbyshire, SK17 8LN, UK GeneWatch Phone: 01287 871898 Fax: 01298 872531 E-mail: [email protected] UK Website: www.genewatch.org Acknowledgements GeneWatch would like to thank Jan van Aken, Sarah Sexton and Paul Johnson for their helpful comments on a draft of this report. Kristina Staley would also like to thank Val Sales for her help in preparing the report. The content of the final report remains the responsibility of GeneWatch UK. Cover photograph DNA genetic fingerprinting on fingerprint blue backdrop. © Adam Hart-Davis, http://www.adam-hart-davis.org/ GeneWatch UK 2 January 2005 Contents 1 Executive summary ................................................................................................................5 2 Introduction...........................................................................................................................10 3 What is the National DNA Database?..................................................................................11 3.1 Using DNA to identify individuals...................................................................................11 3.2 How the police use DNA................................................................................................12 3.3 Concerns -
The Canada's History Beginner's Guide to Genetic
THE CANADA’S HISTORY BEGINNER’S GUIDE TO GENETIC GENEALOGY Read in sequence or browse as you see fit by clicking on any navigation item below. Introduction C. How to proceed A. To test or not Testing strategies for beginners Reasons for testing Recovery guide for those who tested and were underwhelmed Bogus reasons for not testing Fear of the test D. Case studies “The tests are crap” Confirming a hypothesis with autosomal DNA Price Refuting a hypothesis with autosomal DNA Substantive reasons for not testing Confirming a hypothesis with Y DNA Privacy concerns Developing (and then confirming) a hypothesis with Unexpected findings autosomal DNA Developing a completely unexpected hypothesis from B. The ABCs of DNA testing autosomal DNA The four major testing companies (and others) Four types of DNA and three major genetic genealogy tests E. Assorted observations on interpreting DNA tests Mitochondrial DNA (mtDNA) Y DNA F. More resources Autosomal DNA (atDNA) Selected recent publications X DNA Basic information about genetic genealogy Summarizing the tests Blogs by notable genetic genealogists (a selective list) Tools and utilities © 2019 Paul Jones The text of this guide is protected by Canadian copyright law and published here with permission of the author. Unless otherwise noted, copyright of every image resides with the image’s owner. You should not use any of these images for any purpose without the owner’s express authorization unless this is already granted in a cited license. For further information or to report errors or omissions, please contact Paul Jones. CANADASHISTORY.CA ONLINE SPECIAL FEATURE 2019 1 Introduction The “bestest best boy in the land” recently had his DNA tested. -
Comparing the Genealogy Giants: Ancestry.Com, Familysearch, Findmypast and Myheritage Presenter: Sunny Morton
Comparing the Genealogy Giants: Ancestry.com, FamilySearch, Findmypast and MyHeritage Presenter: Sunny Morton Why you should know about all of these sites (even if you use one most often): • Each offers unique content and tools. • All continue to add new records, develop new tools and collect more user-submitted data. • No single website has everything you’ll need or want as you build your tree over time. • Each site offers individual tree building except FamilySearch, which uses a communal tree. • Free access options are available, with access to most features of these sites! Quick Facts & Highlights Ancestry.com FamilySearch.org Findmypast.com MyHeritage.com Annual $198—$298 USD Free $179 USD $129-299 USD subscription Geographic US, Australia/NZ, US, Canada, Mexico, England, Scotland, Scandinavia, England, record Canada, UK, Central/South Wales, Ireland, Germany strengths France, Germany, America, most of US/Canada, Italy, Mexico, Europe, some of Australia/New Zealand Sweden Africa and Asia Featured US census special Vital records and all Parish records: Church Scandinavian collections, historical schedules and other core of England and Germany, England, Jewish record types state- territorial genealogical records Catholic, newspapers censuses, city directories *Prices subject to change. These figures aren’t adjusted for variations in defining records and methods of counting unindexed historical records. Figures cited from company websites and additional data obtained from company representatives. Note: AncestryDNA customers without an Ancestry subscription only have access to some of the site features. What do all the sites have in common at the top membership levels? • Ability to search indexed and unindexed historical records • Core records: U.S. -
Diving Deeper Into Genetic Genealogy Handout
DIVING DEEPER INTO GENETIC GENEALOGY Presented by Melissa A. Johnson, CGSM [email protected] ETHNICITY RESULTS testing has not been particularly useful for The ethnicity information (also known as genealogy, but tests are now more refined biogeographical data) that is part of a test and this is changing. taker’s overall DNA test results is based • STR (short tandem repeat) testing examines on comparisons of the test taker’s DNA to a specific number of STR markers (as chosen sample populations. Each of the DNA testing by the test taker—typically 12, 37, 67, or 111 companies uses different calculations to markers). Tests of 37 markers or more can compare the test taker’s DNA to proprietary be genealogically useful. sample populations, as well as to publicly available sample population data. As a result, With Y-chromosome STR testing, a test taker’s a test taker’s ethnicity information will vary Y-DNA matches are determined by the number from company to company. The science behind of identical STR marker values. Identifying ethnicity results is still in its infancy. Ethnicity how closely related a test taker is to his Y-DNA results can be interesting, but they are not as matches can be difficult, as a number of factors useful for genealogical research as examining need to be considered, including: DNA matches. • the number of non-matching STR marker values in relation to the number of markers tested; and Y-CHROMOSOME DNA TESTING • the mutation rates for the tested markers Y-chromosome DNA is passed down the male (some STR markers mutate at higher rates line, from father to son. -
National DNA Databases 2011
NATIONAL FORENSIC DNA DATABASES COUNCIL FOR RESPONSIBLE GENETICS ANDREW D. THIBEDEAU, J.D. SENIOR FELLOW National DNA Databases 2011 National Forensic DNA Databases Table of Contents Executive Summary .................................................................................................................. - 5 - Summary Table ..................................................................................................................... - 5 - Laws on Point ...................................................................................................................... - 10 - Entry Criteria ...................................................................................................................... - 13 - Introduction & Trends ........................................................................................................... - 15 - National Status Reports Part I - Operational DNA Databases ........................................... - 19 - Australia............................................................................................................................... - 20 - Austria .................................................................................................................................. - 24 - Bahrain................................................................................................................................. - 27 - Belarus ................................................................................................................................. - -
Genetic Genealogy Genetic Genealogy
Family History Research Using Genetic Genealogy Genetic Genealogy ● DNA Testing Companies ● Three most common types of testing using DNA ● Y-DNA ● mtDNA ● Autosomal DNA (atDNA) (including X-dna) ● DNA Analysis Tools Genetic Genealogy ● Main testing companies to choose from: ● Family Tree DNA - www.familytreedna.com ● Y-dna ($139USD), mtDNA ($79-199USD), atDNA ($79, includes ethnicity, not medically focussed) ● Accepts transfers from some other testing companies (possibly free, or ~$19USD) ● 23 and ME – www.23andme.com ● atDNA ($249CDN, includes ethnicity, medically focussed) ● Ancestry – www.dna.ancestry.com ● atDNA ($149CDN, includes ethnicity, not medically focussed) ● MyHeritage - www.myheritage.com ● atDNA $79USD, accepts dna transfers for free ● LivingDNA - www.livingdna.com ● atDNA $143CDN, plans to accept transfers in the near future ● *https://isogg.org/wiki/Autosomal_DNA_testing_comparison_chart (comparison details) Genetic Genealogy ● Three most common types of testing using DNA ● Y-DNA ● mtDNA ● Autosomal DNA (atDNA) (including X-dna) ● Each tests a different type of dna and they CANNOT be compared to each other ! Don’t compare apples to oranges! Genetic Genealogy ● Y-DNA for direct male line (test for men only) ● mtDNA for direct female line (test for men and women) Genetic Genealogy ● Y-DNA mtDNA mtDNA Inheritance male / female Genetic Genealogy ● Y-DNA genetic testing ● The y chromosome is only passed down from a man to his son. ● Every man has a y chromosome that has been passed down to him from thousands and thousands of generations of fathers to sons going back into the dawn of humanity (National Genographic Project). ● Since the start of the use of surnames fathers have tended to pass on their surname along with a y chromosome ● “Surname” projects have become very popular as people try to link together groups of men with a certain surname. -
Where Have All the Indians Gone? Native American Eastern Seaboard Dispersal, Genealogy and DNA in Relation to Sir Walter Raleigh’S Lost Colony of Roanoke
Where Have All the Indians Gone? Native American Eastern Seaboard Dispersal, Genealogy and DNA in Relation to Sir Walter Raleigh’s Lost Colony of Roanoke. Roberta Estes Copyright 2009, all rights reserved, submitted for publication [email protected] or [email protected] Abstract Within genealogy circles, family stories of Native American1 heritage exist in many families whose American ancestry is rooted in Colonial America and traverses Appalachia. The task of finding these ancestors either genealogically or using genetic genealogy is challenging. With the advent of DNA testing, surname and other special interest projects2, tools now exist to facilitate grouping participants in a way that allows one to view populations in historical fashions. This paper references and uses data from several of these public projects, but particularly the Melungeon, Lumbee, Waccamaw, North Carolina Roots and Lost Colony projects3. The Lumbee have long claimed descent from the Lost Colony via their oral history4. The Lumbee DNA Project shows significantly less Native American ancestry than would be expected with 96% European or African Y chromosomal DNA. The Melungeons, long held to be mixed European, African and Native show only one ancestral family with Native DNA5. Clearly more testing would be advantageous in all of these projects. This phenomenon is not limited to these groups, and has been reported by other researchers such as Bolnick (et al, 2006) where she reports finding in 16 Native American populations with northeast or southeast roots that 47% of the families who believe themselves to be full blooded or no less than 75% Native with no paternal European admixture find themselves carrying European or African y-line DNA. -
Searching the Internet for Genealogical and Family History Records
Searching the Internet for Genealogical and Family History Records Welcome Spring 2019 1 Joseph Sell Gain confidence in your searching Using Genealogy sources to find records Course Objectives Improve your search skills Use research libraries and repositories 2 Bibliography • Built on the course George King has presented over several years • “The Complete Idiot’s Guide to Genealogy” Christine Rose and Kay Germain Ingalls • “The Sources – A Guidebook to American Genealogy” –(ed) Loretto Dennis Szuco and Sandra Hargreaves Luebking • “The Genealogy Handbook” – Ellen Galford • “Genealogy Online for Dummies” – Matthew L Helm and April Leigh Helm • “Genealogy Online” – Elizabeth Powell Crowe • “The Everything Guide to Online Genealogy” – Kimberly Powell • “Discover the 101 Genealogy Websites That Take the Cake in 2015” – David A Frywell (Family Tree Magazine Sept 2015 page 16) 3 Bibliography (Continued) • “Social Networking for Genealogist”, Drew Smith • “The Complete Beginner’s Guide to Genealogy, the Internet, and Your Genealogy Computer Program”, Karen Clifford • “Advanced Genealogy – Research Techniques” George G Morgan and Drew Smith • “101 of the Best Free Websites for Climbing Your Family Tree” – Nancy Hendrickson • “AARP Genealogy Online tech to connect” – Matthew L Helm and April Leigh Helm • Family Tree Magazine 4 • All records are the product of human endeavor • To err is human • Not all records are online; most General records are in local repositories Comments • Find, check, and verify the accuracy of all information • The internet is a dynamic environment with content constantly changing 5 • Tip 1: Start with the basic facts, first name, last name, a date, and a place. • Tip 2: Learn to use control to filter hits.