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Dna Test Kit Showdown DNA TEST KIT SHOWDOWN Presented by Melissa Potoczek-Fiskin and Kate Mills for the Alsip-Merrionette Park Public Library Zoom Program on Thursday, May 28, 2020 For additional information from Alsip Librarians: 708.926.7024 or [email protected] Y DNA? Reasons to Test • Preserve and learn about the oldest living generation’s DNA information • Learn about family health history or genomic medicine • Further your genealogy research • Help with adoption research • Curiosity, fun (there are tests for wine preference and there are even DNA tests for dogs and cats) Y DNA? Reasons Not to Test • Privacy • Security • Health Scare • Use by Law Enforcement • Finding Out Something You Don’t Want to Know DNA Definitions (the only science in the program!) • Y (yDNA) Chromosome passed from father to son for paternal, male lines • X Chromosome, women inherit from both parents, men from their mothers • Mitochondrial (mtDNA), passed on to both men and women from their mothers (*New Finding*) • Autosomal (atDNA), confirms known or suspected relationships, connects cousins, determines ethnic makeup, the standard test for most DNA kits • Haplogroup is a genetic population or group of people who share a common ancestor. Haplogroups extend pedigree journeys back thousand of generations AncestryDNA • Ancestry • Saliva Sample • Results 6-8 Weeks • DNA Matching • App: Yes (The We’re Related app has been discontinued) • Largest database, approx. 16 million • 1000 regions • Tests: AncestryDNA: $99, AncestryDNA + Traits: $119, AncestryHealth Core: $149 Kate’s Original Ancestry Results Kate’s Updated Ancestry Results AncestryDNA - Updates • The new update has twice as many samples • That means an even better understanding of genetic signatures around the world, and greater specificity and clarity in geographic ethnicity estimates, for a more detailed picture of your origins • The larger panel allows Ancestry to better distinguish between adjacent regions—like Spain and Portugal—as well as break down larger regions, like East Asia and the Americas, into more detail Kate’s Updated (Again) Ancestry Results Kate’s Ancestry Regional History Kate’s Ancestry Regional Migration Patterns DNA MATCHING Kate’s Ancestry Matches Map Ancestry ThruLines ThruLines finds connections to your DNA matches by looking through other people’s trees for you. Kate’s Traits (Ancestry) Suggests traits like hair and eye color, whether you like sweets and dislike bitter or why you might not like cilantro. Free to existing customers, $20 extra for new customers AncestryHealth The tests offered by AncestryHealth® are physician-ordered and are not diagnostic AncestryHealth® provides reports for selected conditions in the following general areas: Cancer Risk, Heart and Blood Health, Carrier Status and Wellness Purchase AncestryHealth® and answer a short questionnaire upon activation to help determine eligibility PWNHealth will determine eligibility, order your health test if appropriate, and review your reports after your sample is processed In 6-8 weeks your origins results will be available online, with your health reports ready up to 2 business days later Review your results and if you have any concerns, genetic counseling support is available or consult a healthcare provider Ancestry Health Cancer Risk (2): Hereditary Breast & Ovarian Cancer Syndrome & Lynch Syndromes Carrier Status (3): Cystic Fibrosis, Sickle Cell Anemia, Tay-Sachs Disease Heart & Blood Health (4): Cardiomyopathy, Familial Hypercholesterolemia, Hereditary hemochromatosis, Hereditary Thrombophilia Wellness Reports (8): Beta-Carotene, Caffeine Consumption, Lactose Intolerance, Omega-3, Vitamin B12, Vitamin C, Vitamin D, Vitamin E AncestryHealth - Disclaimer • AncestryHealth® includes laboratory tests developed and performed by an independent CLIA-certified laboratory partner, and with oversight from an independent clinician network of board-certified physicians and genetic counselors • The test results are not diagnostic and do not determine your overall chance of developing a disease or health condition • The tests are not cleared or approved by the U.S. Food and Drug Administration • You should consult a healthcare provider before taking any action based on AncestryHealth® reports, including before making any treatment, dietary, or lifestyle changes • AncestryHealth® is not currently available in New York, New Jersey and Rhode Island 23&Me 23&me Saliva Sample Results in 3-5 Weeks FDA-cleared for use with Genetic Health Risk and Carrier Status reports DNA Matching, Family Tree Feature App: Yes Second largest database, approx. 13 million 1500 regions Tests: Health + Ancestry: $199, Ancestry + Traits: $99. VIP Health + Ancestry, $499 (2 kits, priority lab processing, premium customer support and 30 minute results walkthrough by phone – good for one year) Can be ordered online or purchased at CVS, Target, Walgreens, Wal-Mart and Best Buy A percentage of the cost can be paid with money from your healthcare flexible spending account 23&Me Health Reports • Genetic Health Risks: Type 2 Diabetes, Celiac, Parkinson’s, BRCA ½, etc • Wellness Reports: Caffeine, Sleep, Muscle Composition, Weight, etc • Traits: Cheek Dimples, Eye Color, Freckles, Taste and Smell, etc • Carrier Status: Cystic Fibrosis, Sickle Cell Anemia, etc 23&Me DISCLAIMER • Genetic Health Risk reports are intended to provide you with genetic information to inform conversations with a healthcare professional. These reports should not be used to make medical decisions. Always consult with a healthcare professional before taking any medical action. 23&Me Drug Development 23andMe Inc., the Silicon Valley firm known for its ancestry DNA tests, has licensed an antibody it developed to treat inflammatory diseases to Spanish drugmaker Almirall SA. Leveraging its genetic data to develop drugs has become an increasingly important part of 23andMe’s business. More than 10 million customers have taken its DNA tests, and that trove of data can help illuminate new drug targets to treat disease. Drabant Conley said 23andMe is pursuing other drug targets, some of which it may put through clinical trials itself rather than licensing out to other companies. “We had this hypothesis five years ago that we could leverage our genetic data set to develop better drugs, and now we’re seeing this come to fruition,” she said. https://www.bloomberg.com/news/articles/2020-01-09/23andme-licenses-drug-compound-to-spanish-drugmaker-almirall Terry’s Ancestry Terry’s Ancestry Updated Terry’s 23&Me Ethnicity Update (Again) Terry’s Traits Terry’s 23&Me Neanderthal Ancestry Terry’s 23&Me Paternal Haplogroup Terry’s 23&Me Maternal Haplogroup Terry’s Chromosome Painting Your Chromosome Painting is another way of looking at your Ancestry Composition results. It shows a colorful representation of the 23 pairs of chromosomes that make up your genome. Terry’s 23&Me All Reports National Geographic Geno 2.0 FamilyTreeDNA • FamilyTreeDNA • Cheek Swab • Results in 2-12 weeks, depending on the chosen test • DNA Matching, with tree • App: No • Database, 1 million • 24 regions • Tests: Y-DNA: $119-$449, mtDNA: $159, Family Finder: $79, Factoids: $19-49, Factoid Bundle: $149, Health by Vitagene, $49 in addition to your chosen test, Tovana Health: $799 Kate’s FamilyTreeDNA Ancient Origins Living DNA • Living DNA • Cheek Swab • Results take 6-8 weeks since they’ve opened a lab in the US • Ancestry, Wellbeing (fitness and nutrition) • DNA Matching: Yes, called Family Networks • App: No • Database: unknown • 150 regions • Tests: Starter Kit: $49, Ancestry Kit: $99, Wellbeing Kit, $129, Ancestry + Wellbeing, $179 Kate’s Ancestry Living DNA Website Being Updated 4th November 2019 Living DNA November Update Throughout November & December, a number of improvements are being made to your Living DNA portal. These changes have been designed to make the portal easier to use for everyone. Different people will be updated in phased rollouts, at first not all features will be live for everyone, but within the next few weeks they will be. Kate’s Ancestry Updated Kate’s Ancestry Updated (Again) Kate’s Motherline Updated Haplogroup is U5b Subclade 2c2 originating 23,000 years ago from Africa to Scandinavia Kate’s Maternal Haplogroup Map Terry’s Ancestry Updated Terry’s Fatherline Updated Haplogroup J2 Subclade J-M67 originating 21,000 years ago in Asia, the Middle East, Turkey and the Mediterranean Terry’s Paternal Haplogroup Map MyHeritage • MyHeritage • Cheek Swab • Results in 3-4 Weeks • Ancestry (Autosomal), however bought Promethease for health reports • DNA Matching • App: Yes • Database: about 3 million • 42 regions • Tests DNA Kit: $79; Health + Ancestry Kit: $199 Melissa’s Ancestry MyHeritage Chromosome Browser A chromosome browser is a tool that maps a person’s chromosomes graphically. Essentially it is used to visualize shared DNA segments that people who share DNA have in common. MyHeritage AutoClusters AutoClusters — a new genetic genealogy tool that groups together DNA Matches that likely descend from common ancestors in a visual chart. This easy-to-use tool helps you explore your DNA Matches more efficiently in groups rather than as numerous individuals, and gain insights about branches in your family tree. MyHeritage Health Disclaimer • This test reflects your genetic risk for developing specific conditions. It does not tell you whether you have or will develop any condition • We analyze only some of the variants associated with each condition. It is possible that you have a variant that we do not currently
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