Brazilian Journal of Medical and Biological Research (2007) 40: 117-125 Etoricoxib in experimental periodontitis 117 ISSN 0100-879X Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats M.C.F. Azoubel1, 1Departamento de Fisiologia e Farmacologia, A.M.A. Menezes1, 2Departamento de Morfologia, Faculdade de Medicina, D. Bezerra1, R.B. Oriá2, Universidade Federal do Ceará, Fortaleza, CE, Brasil R.A. Ribeiro1 and G.A.C. Brito2 Abstract Correspondence We investigated the effect of etoricoxib, a selective cyclooxygenase- Key words G.A.C. Brito 2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhib- • Alveolar bone loss Departamento de Fisiologia itor, on experimental periodontitis, and compared their gastrointesti- • Inflammation e Farmacologia nal side effects. A ligature was placed around the second upper left • Periodontitis Faculdade de Medicina, UFC molars of female Wistar rats (160 to 200 g). Animals (6 per group) • Cyclooxygenase inhibitors Rua Coronel Nunes de Melo, 1127 • were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg Etoricoxib 60430-270 Fortaleza, CE • Indomethacin Brasil indomethacin, or 0.2 mL saline, starting 5 days after the induction of Fax: +55-85-3366-8333 periodontitis, when bone resorption was detected, until the sacrifice E-mail:
[email protected] on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances Research supported by CNPq and between the cusp tips and the alveolar bone. The gastric mucosa was Fundação Cearense de Pesquisa e examined macroscopically and the periodontium and gastric and Cultura (FUNCAP).