Hua-lin Zhou [email protected] Case Western Reserve University Tel: (216) 368-5730 Cleveland OH. 44106 U.S.A. (216) 212-8883

CURRENT APPOINTMENT Instructor, Institute for Transformative Molecular Medicine, CWRU

EDUCATION AND TRAINING 1994-1998 B.A. Department of Biology Science Hebei Normal University, Shijiazhang, China 1998-2001 M.S. Institute of Molecular Cell Biology Hebei Normal University, Shijiazhang, China 2001-2004 Ph.D. Institute of Genetics and Developmental Biology Chinese Academy of Science, Beijing, China 2005-2012 Postdoctoral fellow Genetics Department, Case Western Reserve University, Cleveland, Ohio

REPRESENTATIVE PUBLICATION 1. Lai T.S., Lindberg R.A., Zhou H.L., Haroon Z.A., Dewhirst M.W., Hausladen A., Juang Y.L., Stamler J.S., Greenberg C.S. (2017) Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide. Sci Rep. 2017 Nov 23;7(1): 2. Zhou H.L., and Lou H. (2016) In Vitro Analysis of Ribonucleoprotein Complex Remodeling and Disassembly. Methods Mol Biol. 2016;1421:69-78 3. Zhou H.L., Mangelsdorf M, Liu J, Zhu L, Wu JY. RNA-binding proteins in neurological diseases. Sci China Life Sci. 2014 Apr;57(4):432-44. 4. Zhou H.L., Geng C.Y., Luo G.B. and Lou H. (2013) The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP. Genes &Development 27(9):1046-1058 5. Zhou H.L., Wise J.A., Luo G.B. and Lou H. (2013) Regulation of Alternative Splicing by Local Histone Modifications: Emerging Roles for RNA-guided Mechanisms. Nucleic Acids Research 42(2):701-13 6. Hinman M.N., Zhou H.L., Sharma, A. and Lou H. All three RNA recognition motifs and the hinge region of HuC play distinct roles in the regulation of alternative splicing. Nucleic Acids Research 41(9):5049-61 7. Zhou H.L., Hinman M.N., Barron V.A., Zhou G.J., Luo G.B., Siegel R.E. and Lou H. (2011) Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. PNAS 108: E627-635.

1 Hua-Lin Zhou Ph.D 8. Zhou H.L, Lou H. (2008) Repression of pre-spliceosomal complex formation at two distinct steps by Fox-1/Fox-2 proteins. Mol. Cell. Biol. 28:5507-5516. 9. Zhou H.L., Baraniak A.P., Lou H. (2007) A role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/CGRP alternative RNA processing. Mol. Cell. Biol. 27: 830-841. 10. Zhu H., Zhou H.L., Hasman R.A., Lou H. (2006) Hu proteins regulate polyadenylation by blocking sites containing U-rich sequences. J Biol.Chem. 282: 2203-2210. 11. Zhou H.L., Cao WH, Cao Y28R, Liu J, Hao YJ, Zhang JS, Chen SY (2006) Roles of ethylene receptor NTHK1 domains in plant growth, stress response and protein phosphorylation. FEBS Letters, 580: 1239-1250. 12. Zhou H.L., He SJ, Cao YR, Chen T, Du BX, Chu CC, Zhang JS, Chen SY (2006) OsGLU1, a Putative Membrane-bound Endo-1,4-ß-D- glucanase from Rice, Affects Plant Internode Elongation. Plant Mol Biol. 60: 137-151. 13. Zhang Z.G.§, Zhou, H.L.§, Chen, T., Gong, Y., Cao, W.H., Wang, Y.J., Zhang, J.S., and Chen, S.Y. (2004) Evidence for serine/threonine and hsitidine kinase activity in the tobacco ethylene receptor protein NTHK2. Plant Physiol. 136, 2971-2981. (§Contribute equally) 14. Xie, C.§, Zhang, J.S.§, Zhou, H.L.§, Li, J., Zhang, Z.G., Wang, D.W., and Chen, S.Y. * (2003). Serine/threonine kinase activity in the putative histidine kinase-like ethylene receptor NTHK1 from tobacco. Plant J. 33, 385-393. (§Contribute equally). 15. Zhou H.L., Ma L.G., Liu M., Mao G.H., Sun D.Y. (2001) Secretion of Calmodulin in Transgenic SCaM-GFP Tobacco. Journal of Integrative Plant Biology. 43(12) 1300-1302. 16. Ma L.G., Fan Q.S., Yu Z.Q., Zhou H.L., Sun D.Y. (2000). Does Al inhibit pollen germination and tube growth via extracellular calmodulin? Plant Cell Physiology. 41:372- 376. 17. TIAN X.H., LI X.P., Zhou H.L., Zhang, J.S., Gong Z.Z., Chen, S.Y. (2005) OsDREB4 Genes in Rice Encode AP2-Containing Proteins that Bind Specifically to the Dehydration- Responsive Element. Journal of Integrative Plant Biology. 47: 467-476. 18. Zhang J.S., Xie C., Zhang Z.G., Zhou H.L., Chen S.Y. (2002) Tobacco ethylene receptor NTHK1 is involved in abiotic stress responses and possesses serine/threonine kinase activity. NATO ADVANCED RESEARCH WORKSHOP ON ETHYLENE 2002S1-P16 19. Wang Y.J., Zhang Z.G., He X.J., Zhou H.L., Wen Y.X., Dai J.X., Zhang J.S., Chen S.Y. (2003) A rice transcription factor OsbHLH1 is involved in cold stress response. Theor Appl Genet, 107(8):1402-9. 20. Cao W.H, Liu J, He X.J., Mu R.L., Zhou H.L., Chen S.Y., Zhang J.S. (2007) Modulation of Ethylene Responses Affects Plant Salt-Stress Responses. Plant Physiol. 143(2):707-719.

2 Hua-Lin Zhou Ph.D