A Phase 2 Study of the LSD1 Inhibitor IMG-7289 (Bomedemstat) in Patients with Advanced Myelofibrosis
A Phase 2 Study of the LSD1 Inhibitor IMG-7289 (Bomedemstat) in Patients with Advanced Myelofibrosis Harry Gill* 1, Abdulraheem Yacoub2, Kristen Pettit3, Terrence Bradley4, Aaron Gerds5, Maciej Tatarczuch6, Jake Shortt7, Natasha Curtin7, James Rossetti8, Kate Burbury9, Adam Mead10, Joachim Göthert11, SteFFen Koschmieder12, Anna Halpern13, Amber Jones14, JenniFer Peppe14, Georges Natsoulis15, Willis Navarro14, William Stevenson16, Joanne Ewing17 , Ruben Mesa18, Elisa Rumi19, Nicola Vianelli20, Monia Marchetti21, Claire Harrison22, Alessandro Vannucchi23, Justin Watts4, David Ross24, Moshe Talpaz3, Hugh RienhofF25 INTRODUCTION RESULTS RESULTS LSD1 is a key haematopoietic regulator and overexpressed in MPNs TSS at 12 weeks TSS at 24 weeks Spleen volume reduction at 24 weeks Haemoglobin and transfusion changes OBJECTIVE To study the efficacy and safety and efficacy of IMG-7289 in patient with myelofibrosis Reduction in MAF METHODS Treatment plan CONCLUSIONS AFFILIATIONS AND CONTACT 1Department of Medicine, the University of Hong Kong, Hong Kong, China, 2Hematology, University of Kansas, Kansas City, 3Rogel Cancer Center, University of Michigan, Ann Arbor, 4Sylvester Comprehensive Cancer Center, University of Miami, Miami, 5Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States, 6School of Clincal Sciences, Monash University, 7Haematology, Monash Health, Melbourne, Australia, 8Hillman Cancer Center, University of Pittsburgh, Pittsburgh, United States, 9Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia, 10Weatherall
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