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Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development
Nat. Prod. Bioprospect. DOI 10.1007/s13659-016-0115-5 REVIEW Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development Satheesh Kumar Palanisamy . N. M. Rajendran . Angela Marino Received: 19 November 2016 / Accepted: 14 December 2016 Ó The Author(s) 2017. This article is published with open access at Springerlink.com Abstract This present study reviewed the chemical diversity of marine ascidians and their pharmacological applications, challenges and recent developments in marine drug discovery reported during 1994–2014, highlighting the structural activity of compounds produced by these specimens. Till date only 5% of living ascidian species were studied from\3000 species, this study represented from family didemnidae (32%), polyclinidae (22%), styelidae and polycitoridae (11–12%) exhibiting the highest number of promising MNPs. Close to 580 compound structures are here discussed in terms of their occurrence, structural type and reported biological activity. Anti-cancer drugs are the main area of interest in the screening of MNPs from ascidians (64%), followed by anti-malarial (6%) and remaining others. FDA approved ascidian compounds mechanism of action along with other compounds status of clinical trials (phase 1 to phase 3) are discussed here in. This review highlights recent developments in the area of natural products chemistry and biotechnological approaches are emphasized. Keywords Cancer Á Cytotoxicity Á Diversity Á Metabolites Á Pharmacology 1 Introduction from marine invertebrates, especially sponges, ascidians, bryozoans and molluscs in which some of them are The study of marine natural products (MNPs) is becoming approved by FDA and currently utilized in clinical trials ever more sophisticated and an increasingly collaborative [1]. -
A Redescription of Syncarpa Composita (Ascidiacea, Stolidobranchia) with an Inference of Its Phylogenetic Position Within Styelidae
A peer-reviewed open-access journal ZooKeys 857: 1–15 (2019) Redescription of Syncarpa composita 1 doi: 10.3897/zookeys.857.32654 RESEARCH ARTICLE http://zookeys.pensoft.net Launched to accelerate biodiversity research A redescription of Syncarpa composita (Ascidiacea, Stolidobranchia) with an inference of its phylogenetic position within Styelidae Naohiro Hasegawa1, Hiroshi Kajihara2 1 Department of Natural History Sciences, Graduate School of Science, Hokkaido University, Kita 10 Nishi 8 Kitaku, Sapporo, Hokkaido 060-0810, Japan 2 Faculty of Science, Hokkaido University, Kita 10 Nishi 8 Kitaku, Sapporo, Hokkaido 060-0810, Japan Corresponding author: Naohiro Hasegawa ([email protected]) Academic editor: Tito Lotufo | Received 25 December 2018 | Accepted 6 May 2019 | Published 24 June 2019 http://zoobank.org/2183A9EC-C4B7-4863-B03B-EB5346D7B95E Citation: Hasegawa N, Kajihara H (2019) A redescription of Syncarpa composita (Ascidiacea, Stolidobranchia) with an inference of its phylogenetic position within Styelidae. ZooKeys 857: 1–15. https://doi.org/10.3897/ zookeys.857.32654 Abstract Two species of styelid colonial ascidians in the genus Syncarpa Redikorzev, 1913 are known from the northwest Pacific. The valid status of the lesser known species, Syncarpa composita (Tokioka, 1951) (type locality: Akkeshi, Japan), is assessed here. To assess the taxonomic identity of S. composita, we com- pared one of the syntypes and freshly collected topotypes of S. composita with a syntype of S. oviformis Redikorzev, 1913 (type locality: Ul’banskij Bay, Russia). Specimens of S. composita consistently differed from the syntype of S. oviformis in the number of oral tentacles, the number of size-classes of transverse vessels, and the number of anal lobes. -
P30 Laboratory Cultivation of Ciona and Other Tunicates
Cover and back cover designed by Laurel Hiebert – Drawings modified fromLahille, M.F., 1890. Contributions à l’étude anatomique et taxonomique des Tuniciers. Ph.D. Thesis, Fac. Sciences Paris. Toulouse. ORGANIZING COMMITTEE Stefano Tiozzo Rémi Dumollard Alexandre Alié Janet Chenevert Elisabeth Christians Clare Hudson Alex McDougall Hitoyoshi Yasuo WEBSITE AND COMMUNICATION COMMITTEE Faisal Bekkouche Frédéric Bonino Delphine Dauga SCIENTIFIC COMMITTEE Rémi Dumollard (Sorbonne University, CNRS – France) Stefano Tiozzo (Sorbonne University, CNRS – France) Cristian Cañestro (Universitat de Barcelona – Spain) Bo Dong (Ocean University of China – China) Kaoru Imai (Osaka University – Japan) Kazuo Inaba (University of Tsukuba – Japan) Marie Nydam (Centre College – USA) Rosana Rocha (Universidade Federal do Paraná – Brazil) Ute Rothbächer (Universität Innsbruck – Austria) Antonietta Spagnuolo (Stazione Zoologica Anton Dohrn – Italy) Bob Zeller (San Diego State University – USA) CONTENTS GENERAL INFORMATION ..........................................pag. 5 INFORMATION ON THE MEETING .........................pag. 7 PROGRAM AT GLANCE ...............................................pag. 8 PROGRAM ........................................................................pag. 10 TALKS ABSTRACTS ......................................................pag. 15 POSTERS ABSTRACTS .................................................pag. 85 LIST OF PARTICIPANTS ...............................................pag. 151 SPONSORS AND HOST INSTITUTIONS ................pag. -
Ascidiacea (Chordata: Tunicata) Do Litoral Tropical Brasileiro
1 Tito Monteiro da Cruz Lotufo Ascidiacea (Chordata: Tunicata) do litoral tropical brasileiro São Paulo 2002 2 Tito Monteiro da Cruz Lotufo Ascidiacea (Chordata: Tunicata) do litoral tropical brasileiro Tese apresentada ao Insituto de Biociências da Universidade de São Paulo, para obtenção do Título de Doutor em Ciências, na Área de Zoologia. Oridentador: Prof. Dr. Sérgio de Almeida Rodrigues São Paulo 2002 3 Ficha Catalográfica Lotufo, Tito Monteiro da Cruz Ascidiacea (Chordata: Tunicata) do litoral tropical brasileiro 183 pp. Tese (Doutorado) - Instituto de Biociências da Universidade de São Paulo. Departamento de Zoologia. 1. Ascidiacea 2. Tunicata 3. Ascídias I. Universidade de São Paulo. Instituto de Biociências. Zoologia. Comissão Julgadora ______________________________ _______________________________ Prof. Dr. Edmundo Ferraz Nonato Profa. Dra. Rosana Moreira da Rocha ______________________________ _______________________________ Profa. Dra. Antonia Cecilia Z. Amaral Prof. Dr. Alvaro Esteves Migotto _________________________________ Prof. Dr. Sérgio de Almeida Rodigues Orientador 4 ctÜt _xà•v|t? Åxâ tÅÉÜ? ÑxÄt ÖâtÄ xâ àxÇ{É t Åt|á á|ÇvxÜt twÅ|Üt†ûÉ 5 “Se você deseja avançar para o infinito, explore o finito em todas as direções.” Johann Wolfgang von Goethe (1749-1832) 6 Agradecimentos Os resultados apresentados nesta tese não foram fruto unicamente do meu trabalho, mas de um grande número de colaboradores, como se esperaria de um projeto com esta abrangência. Desta forma, tomo a liberdade de estender-me um pouco neste item. Esta é uma tentativa de se fazer justiça a algumas das pessoas que contribuíram de uma forma ou de outra para a realização deste projeto. Assim sendo, desejo expressar meus mais sinceros agradecimentos : Ao Prof. -
Phylogenetic Comparison of Egg Transparency in Ascidians by Hyperspectral Imaging Takumi T
www.nature.com/scientificreports OPEN Phylogenetic comparison of egg transparency in ascidians by hyperspectral imaging Takumi T. Shito1, Naohiro Hasegawa2, Kotaro Oka1,3,4* & Kohji Hotta1* The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to frst characterize the transparency of ascidian eggs across diferent species and to infer a phylogenetic relationship among multiple taxa in the class Ascidiacea. We measured the transmittance of 199 eggs from 21 individuals using a hyperspectral camera. The spectrum of the visual range of wavelengths (400– 760 nm) varied among individuals and we calculated each average transmittance of the visual range as bio-transparency. When combined with phylogenetic analysis based on the nuclear 18S rRNA and the mitochondrial cytochrome c oxidase subunit I gene sequences, the bio-transparencies of 13 species were derived from four diferent families: Ascidiidae, Cionidae, Pyuridae, and Styelidae. The bio-transparency varied 10–90% and likely evolved independently in each family. Ascidiella aspersa showed extremely high (88.0 ± 1.6%) bio-transparency in eggs that was maintained in the “invisible” larva. In addition, it was indicated that species of the Ascidiidae family may have a phylogenetic constraint of egg transparency. Many marine organisms such as jellyfsh, siphonophores, some crustaceans, pteropods, some squids, salps, and fsh larvae are transparent1–6. Somewhat surprisingly, the biological role of transparency in living organ- isms appears to have received little attention presumably though it confers a selective advantage such as aiding approach to prey or avoidance of predators 2,4,7,8.