nutrients Article Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults Carolyn S. Kaufman 1, Eric D. Vidoni 2, Jeffrey M. Burns 2, Mohammed R. Alwatban 3 and Sandra A. Billinger 1,3,* 1 Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA;
[email protected] 2 University of Kansas Alzheimer’s Disease Center, Fairway, KS 66103, USA;
[email protected] (E.D.V.);
[email protected] (J.M.B.) 3 Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 2002, Kansas City, KS 66160, USA;
[email protected] * Correspondence:
[email protected] Received: 21 February 2020; Accepted: 2 March 2020; Published: 5 March 2020 Abstract: Cerebral blood flow (CBF) decreases across the lifespan, and chronic conditions such as dementia and stroke accelerate this decline. Impaired CBF results in reduced delivery of oxygen and nutrients, which can damage the brain over time. Thus, there is a need to identify lifestyle interventions, including diet and exercise, to maintain CBF with aging and in the presence of chronic disease. In the present study, we used transcranial Doppler ultrasound to record middle cerebral artery velocity (MCAv), a surrogate measure of CBF, during moderate-intensity exercise in sedentary, cognitively normal older adults (n = 90). A multiple linear regression model (F(4, 85) = 3.21, p = 0.02) showed that self-reported omega-3 supplement use significantly moderated the association between age and mean exercising MCAv in these individuals (p = 0.01).