Author Manuscript Published OnlineFirst on September 4, 2013; DOI: 10.1158/1078-0432.CCR-13-1337 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1 amplified ovarian cancer AUTHORS AND AFFILIATIONS Dariush Etemadmoghadam1,2,3, George Au-Yeung1,4, Meaghan Wall5, Chris Mitchell1, Maya Kansara1, Elizabeth Loehrer1, Crisoula Batzios5, Joshy George1,4, Sarah Ftouni1, Barbara A Weir6,7, Scott Carter7, Irma Gresshoff3,8, Linda Mileshkin1,2,9, Danny Rischin1,2,9, William C Hahn6,7, Paul M Waring3,8, Gad Getz7, Carleen Cullinane1,10, Lynda J Campbell5 and David Bowtell1,2,4 1Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; 2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; 3Department of Pathology, University of Melbourne, Parkville, Victoria, Australia; 4Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia; 5Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Melbourne, Victoria, Australia; 6Dana-Farber Cancer Institute, Boston, Massachusetts, USA; 7The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; 8Centre for Translational Pathology, University of Melbourne, Parkville, Victoria, Australia; 9Department of Medicine, University of Melbourne, Parkville, Victoria, Australia; 10Translational Research Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. RUNNING TITLE Resistance to CDK2 inhibitors in CCNE1 amplified cancer KEYWORDS Ovarian Cancer, Resistance, Cyclin E1, CDK inhibitors CORRESPONDING AUTHOR Professor David DL Bowtell Peter MacCallum Cancer Centre
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