KDM7 Is a Dual Demethylase for Histone H3 Lys 9 and Lys 27 and Functions in Brain Development
Downloaded from genesdev.cshlp.org on October 1, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION elegans to humans and is characterized by the presence of KDM7 is a dual demethylase a PHD-type zinc finger motif in addition to the JmjC do- for histone H3 Lys 9 and Lys main (Supplemental Fig. S1A). Whereas the human genes for PHF8 and PHF2 are associated with X-linked mental 27 and functions in brain retardation and hereditary sensory neuropathy type I, respectively (Hasenpusch-Theil et al. 1999; Laumonnier development et al. 2005; Abidi et al. 2007; Koivisto et al. 2007), little is Yu-ichi Tsukada,1,2,3 Tohru Ishitani,4 known about KIAA1718. Bioinformatic analysis of the 1,2,5 JmjC domains of KIAA1718, PHF8, and PHF2 indicated and Keiichi I. Nakayama that predicted Fe(II)- and a-ketoglutarate (a-KG)-binding 1Division of Cell Biology, Medical Institute of Bioregulation, sites are conserved, with the exception of the former in Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan; PHF2, and that they share extensive similarity with the 2CREST, Japan Science and Technology Agency (JST), JmjC domain of JHDM1/KDM2 (Supplemental Fig. S1B). Kawaguchi, Saitama 332-0012, Japan; 3PRESTO, Japan Science Conservation of residues within the putative cofactor- and Technology Agency (JST), Kawaguchi, Saitama 332-0012, binding sites of KIAA1718 suggested that this protein Japan; 4Division of Cell Regulation Systems, Medical Institute might possess histone demethylase activity, and there- of Bioregulation, Kyushu University, Higashi-ku, Fukuoka fore might also contribute to transcriptional regulation of 812-8582, Japan genes in the nervous system.
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