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Historical Overview of the Human Population-Genetic Studies In
L. Lasić et al.: Population-Genetic Studies in Bosnia and Herzegovina, Coll.Coll. Antropol. Antropol. 40 40 (2016) (2016) 2: 2: 145–149 145–149 Review HHistoricalistorical OOverviewverview ofof thethe HumanHuman Population-Population- GGeneticenetic StudiesStudies inin BBosniaosnia andand Herzegovina:Herzegovina: SSmallmall Country,Country, GGreatreat DDiversityiversity LLejlaejla LasiLasić, JJasminaasmina HindijaHindija Čaakar,kar, GGabrijelaabrijela RRadosavljeviadosavljević, BBelmaelma KKalamujialamujić aandnd NarisNaris PojskiPojskić University of Sarajevo, Institute for Genetic Engineering and Biotechnology, Sarajevo, Bosnia and Herzegovina AABSTRACTB S T R A C T Modern Bosnia and Herzegovina is a multinational and multi-religious country, situated in the western part of the Balkan Peninsula in South-eastern Europe. According to recent archaeological fi ndings, Bosnia and Herzegovina has been occupied by modern humans since the Palaeolithic period. The structure of Bosnia-Herzegovina’s human populations is very complex and specifi c, due to which it is interesting for various population-genetic surveys. The population of Bos- nia and Herzegovina has been the focus of bio-anthropological and population genetics studies since the 19th century. The fi rst known bio-anthropological analyses of Bosnia-Herzegovina population were primarily based on the observation of some phenotypic traits. Later examinations included cytogenetic and DNA based molecular markers. The results of all studies which have been done up to date showed no accented genetic difference among the populations (based on geo- graphical regions) with quite high diversity within them. Human population of Bosnia and Herzegovina is closely related to other populations in the Balkans. However, there are still many interesting features hidden within the existing diver- sity of local human populations that are still waiting to be discovered and described. -
Information for Instructor
Using a Single-Nucleotide Polymorphism to Predict Bitter-Tasting Ability 21 INFORMATION FOR INSTRUCTOR CONCEPTS AND METHODS This laboratory can help students understand several important concepts of modern biology: • The relationship between genotype and phenotype. • The use of single-nucleotide polymorphisms (SNPs) in predicting drug response (pharmacogenetics). • A number of SNPs are inherited together as a haplotype. • The movement between in vitro experimentation and in silico computation. The laboratory uses several methods for modern biological research: • DNA extraction and purification. • Polymerase chain reaction (PCR). • DNA restriction. • Gel electrophoresis. • Bioinformatics. LAB SAFETY The National Association of Biology Teachers recognizes the importance of laboratory activities using human body samples and has developed safety guidelines to minimize the risk of transmitting serious disease. ("The Use of Human Body Fluids and Tissue Products in Biology," News & Views, June 1996.) These are summarized below: • Collect samples only from students under your direct supervision. • Do not use samples brought from home or obtained from an unknown source. • Do not collect samples from students who are obviously ill or are known to have a serious communicable disease. • Have students wear proper safety apparel: latex or plastic gloves, safety glasses or goggles, and lab coat or apron. • Supernatants and samples may be disposed of in public sewers (down lab drains). • Have students wash their hands at the end of the lab period. • Do not store samples in a refrigerator or freezer used for food. The risk of spreading an infectious agent by this lab method is much less likely than from natural atomizing processes, such as coughing or sneezing. -
Bitter Taste Perception in Neanderthals Through the Analysis of The
View metadata, citation and similar papers Downloadedat core.ac.uk from http://rsbl.royalsocietypublishing.org/ on March 22, 2016 brought to you by CORE provided by Repositorio Institucional de la Universidad de Oviedo Biol. Lett. (2009) 5, 809–811 The most extensively studied taste variation in doi:10.1098/rsbl.2009.0532 humans is sensitivity to a bitter substance called phe- Published online 12 August 2009 nylthiocarbamide (PTC). Although approximately 75 Evolutionary biology per cent of the world population perceives this sub- stance as intensely bitter, it is virtually tasteless for the remaining 25 per cent of the population (Kim & Bitter taste perception in Drayna 2004). This is owing to a dominant ‘taster’ allele that shows a similar frequency to the recessive Neanderthals through the ‘non-taster’ allele. PTC itself is not found in any vegetable, but chemically similar substances that analysis of the TAS2R38 produce an identical response to PTC are present in gene many plant foods (including Brussels sprouts, cabbage, broccoli and others). It was discovered Carles Lalueza-Fox1,*, Elena Gigli1, (Kim et al. 2003) that most of the variation in PTC Marco de la Rasilla2, Javier Fortea2 sensitivity is related to polymorphisms at the and Antonio Rosas3 TAS2R38 gene, a single 1002 bp coding exon that encodes a 333-amino-acid, G-protein-coupled recep- 1Institut de Biologia Evolutiva, CSIC-UPF, Dr. Aiguader 88, 08003 Barcelona, Spain tor. The TAS2R38 gene has three amino-acid changes 2A´ rea de Prehistoria, Departamento de Historia, Universidad de Oviedo, in high frequencies that determine only five main hap- Teniente Alfonso Martı´nez s/n, 33011 Oviedo, Spain lotypes. -
Hidden Nature, the Startling Insights of Viktor Schauberger
Contents Foreword by David Bellamy 11 Introduction 13 Part One: An Alternative Worldview 1. Schauberger's Vision 25 The water wizard 26; Log flumes 29; Water, source of life 31; Motion is crucial 32; Temperature controls 34; Evolution 34; Balance 35; Implosion 35; The visionary 36. 2. Different Kinds of Energy 39 Subtle energies 39; Schauberger's worldview 39; Why the mystery? 40; Degrees of energy 41; The vortex as the key to creative evolution 42; Energies as creative process 43; Spiritual science 44; Different dimensions 45; Changing octaves 47. 3. The Attraction and Repulsion of Opposites 49 The Sun as a fertilizing entity 49; Polarities 51; Opposites working towards balance 52; Gravity and levity 53. 4. Nature's Patterns and Shapes 55 Sound as resonance 55; Resonance is about qualities 58; Plants have perception and memory 59; Cymatics 60; Patterns and shapes 61; Patterns in motion 62; Rhythms within the solar system 62; The confrontation of two geometric systems 63; Sacred geometry 64; The golden mean 66; The magic of the egg form 67. Part Two: How the World Works 5. Energy Production 73 The inefficiency of modern technology 73; Entropy and ectropy 74; Scientific 'laws' 74; Energy pollution 75; The choice before us 77; Energy defines quality 79; The creative energy vortex 80. 6. Motion — the Key to Balance 85 We use the wrong form of motion 85; The 'original' motion 87; Types of motion 89. 7. The Atmosphere and Electricity 93 Earth's atmosphere 94; Electricity 96; The terrestrial biocondenser 97; Earth as an accumulator of energy 99; Electricism and magnetism 100; Storms, water vapour and climate 101. -
Deep Lights Lesson Plan
Bioluminescence 2009: ocean Living Light on the Deep Sea Floor Expedition Deep Lights www.oceanexplorer.noaa.gov Focus Light-producing processes and organisms in deep-sea environments Grade Level 7-8 (Life Science/Physical Science) Focus Question Image credit: NOAA. How do deep-sea organisms produce light in deep ocean environments? Learning Objectives ] Students will be able to compare and contrast chemiluminescence, bioluminescence, fluorescence, phosphorescence, and triboluminescence. ] Given observations on materials that emit light under certain Image credit: NOAA. conditions, students will be able to infer whether the light- producing process is chemiluminescence, fluorescence, phosphorescence, or triboluminescence. ] Students will be able to explain three ways in which the ability to produce light may be useful to deep-sea organisms. Materials @ Ultraviolet lamp (see Extensions) Image credit: NOAA. @ Materials for demonstrating fluorescence, phosphorescence, chemiluminescence, and triboluminescence; see “Learning Procedure” Step 1b and “Extensions” for a partial list of suppliers @ Watch glasses, petri dishes, bottle caps, or similar containers to hold small samples of solid materials @ Clear glass 50 ml beakers, graduated cylinders, or similar containers for liquid materials @ Plastic sandwich bags, two for each student group @ Pliers; one for each student group, or groups may share Image credit: NOAA. @ One or more large cardboard cartons to provide a darkened space for viewing materials under ultraviolet light, if the classroom -
Triboluminescence and Triboelectrification by the Motion of Mercury Over Glass Coated with Scintillator Dyes
1726 J. Electrochem. Soc.: SOLID-STATE SCIENCE AND TECHNOLOGY December 1973 Acknowledgment 2. J. R. Brown and J. H. O'Donnell, Macromolecules, 5, 109 (1972). The authors would like to recognize R. D. Heiden- 3. M. J. Bowden and L. F. Thompson, J. Appl. Poly- reich and E. D. Feit for helpful discussions and C. M. mer Sci., In press. Melliar-Smith for supplying the tungsten substrate. 4. R. Glang and L. V. Gregor, in "Handbook of Thin Film Technology," L. I. Maissel and R. Glang, Manuscript submitted March 8, 1973; revised manu- Editors, Chap. 7, McGraw-Hill, Book Company, script received July 25, 1973. New York (1970). 5. M. Hatzakis, This Journal, 116, 1033 (1971). Any discussion of this paper will appear in a Discus- 6. J. M. Shaw and J. A. Amick, RCA Rev., 31, 306 sion Section to be published in the June 1974 JOURNAL. (1970). 7. L. F. Thompson, E. D. Feit, C. M. Melliar-Smith, REFERENCES and R. D. Heidenreich, J. Appl. Phys., In press. 1. S. Magdo, M. Hatzakis, and Ch. Ting, IBM J. Res. 8. R. D. Heidenreich, E. D. Felt, L. F. Thompson, and Develop., 15, 446 (1970). C. M. Melliar-Smith, ibid., In press. Triboluminescence and Triboelectrification by the Motion of Mercury Over Glass Coated with Scintillator Dyes Csaba P. Keszthelyi* and Allen J. Bard** Department of Chemistry, The University o] Texas at Austin, Austin, Texas 78712 ABSTRACT The conversion of mechanical energy into electrical energy and light (triboelectrification and triboluminescence) by the movement of mercury over glass surfaces coated with scintillator compounds was investigated. -
Abstracts of Papers Presented at the Mammalian Genetics Group
Genet. Res., Camb. (1982), 40, pp. 99-106 gg Printed in Great Britain Abstracts of papers presented at the Mammalian Genetics Group meeting, held at the Royal Free Hospital Medical School on 26 and 27 November 1981 Are patterns of cell differentiation reflected in mammalian gene maps? BY LARS-G. LUNDIN Department of Medical and Physiological Chemistry, Biomedicum, University of Uppsala, Box 575 S-751 23, Uppsala, Sweden There are two separate types of gene homologies. New genetic material can arise by gene duplication, either by regional duplication or by tetraploidization. Both these mechanisms of gene duplication give rise to paralogous genes through subsequent divergent evolution. Thus, paralogous genes exist within a species and have a common ancestral gene. Orthologous genes are found in different species and have diverged from their common ancestral gene as part of the process of speciation and separate evolution. Linkage conservation, as reflected by orthologous chromo- somal regions, has been demonstrated for quite extensive parts of mammalian chromosomes. Three possible groups of paralogous chromosomal regions in mouse and man will be suggested. The phenomenon of differential gene silencing and its consequence for our ability to detect paralogies will be described and exemplified. It is suggested that there may be a temporal relationship between closely linked genes. This will be exemplified by genes likely to be active in cells derived from the neural crest. Thus, it seems that genes for inner ear defects in the mouse are often closely linked to coat colour genes. Some other genes clustering around pigment genes will be discussed. Comparative aspects of the evolution of 'dispersed' and 'tandem' families of sequences in species of rodents BY GABRIEL DOVER AND S. -
Mouth-Lighting.Pdf
Chemistry Mouth Lightning Primary Audience: All Ages Description: Participants will make observations about triboluminescence using Wintergreen Lifesavers. Keywords: Triboluminescence, Bioluminescence, Cold Light Concepts: • Light can be produced without heat. • Light produced without heat is called "cold light" • Cold light can be produced by crushing certain materials. • Some materials can absorb ultraviolet light, which we cannot see, and reemit it as light waves we can see. Materials: • Wintergreen Lifesavers • Pliers (optional) • Sugar Cubes (optional) Instructions: For this experiment, I'm going to give you some candy. Since the candy is part of the experiment, I want you to promise me that you won't eat the candy until I explain how to do the experiment. Okay?? Great! Each of you will get two pieces of candy. One to use in while you are in this workshop and one to take home, so you can do this experiment again after you get home! Be certain you give this bit of information before you hand out the candy! Does everyone have two pieces of candy now? Then you need to put one in your carrying bag, and carefully hold on to the other one for just a little while longer. Don't put it in your mouth just yet, because if it gets wet, the experiment won't work. If you hands are sweaty, hold the candy between your thumb and forefinger, like this. When we get ready to do this experiment, you are going to put the candy in your mouth just a little to the side, with the widest part of the candy between your teeth, like this. -
Alternatives to Relational Databases in Precision Medicine: Comparison of Nosql Approaches for Big Data Storage Using Supercomputers
ALTERNATIVES TO RELATIONAL DATABASES IN PRECISION MEDICINE: COMPARISON OF NOSQL APPROACHES FOR BIG DATA STORAGE USING SUPERCOMPUTERS by Enrique Israel Velazquez MS, University of Pittsburgh, 2011 MPH, University of Pittsburgh, 2011 MD, University of Nuevo Leon Medical School, Mexico, 2005 Submitted to the Graduate Faculty of Department of Human Genetics Graduate School of Public Health in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Pittsburgh 2015 UNIVERSITY OF PITTSBURGH Graduate School of Public Health This dissertation was presented by Enrique Israel Velazquez It was defended on June 29, 2015 and approved by Dissertation Advisor: Michael Barmada, Ph.D., Associate Professor, Department of Human Genetics, Graduate School of Public Health; Associate Professor, Department of Biomedical Informatics; Director, Center for Computational Genetics, Graduate School of Public Health; Associate Director, Center for Simulation and Modeling, University of Pittsburgh; Co-Director, Informatics Resource Center, Institute for Personalized Medicine, University of Pittsburgh Schools of the Health Sciences and University of Pittsburgh Medical Center (UPMC) Committee Members: Eleonor Feingold, Ph.D., Professor, Department of Human Genetics; Professor, Department of Biostatistics; Associate Dean for Education, Office of the Dean; Senior Associate Dean, Office of the Dean, Graduate School of Public Health, University of Pittsburgh Harry Hochheiser, Ph.D., Assistant Professor, Department of Biomedical Informatics, School of Medicine, University of Pittsburgh Alexandros Labrinidis, Ph.D., Associate Professor, Department of Computer Science; Co-Director, Advanced Data Management Technologies Laboratory, University of Pittsburgh; Adjunct Associate Professor, Computer Science Department, Carnegie Mellon University Ryan Minster, Ph.D., Assistant Professor, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh ii Copyright © by Enrique Israel Velazquez 2015 iii Michael Barmada, Ph.D. -
Surface Distribution and X-Ray Emission from Scotch Tape
Surface Distribution and X-Ray Emission From Scotch Tape by Kelly McGuire A senior thesis submitted to the Department of Physics in partial fulfillment of the requirements for the degree of Bachelor of Science Department of Physics Brigham Young University – Idaho July – 2012 BRIGHAM YOUNG UNIVERSITY – IDAHO DEPARTMENT APPROVAL of a senior thesis submitted by Kelly McGuire This thesis has been reviewed by the research committee and senior thesis coordinator/advisor and has been found to be satisfactory. Date David Oliphant, Senior Thesis Coordinator/Advisor Date Kevin Kelley, Committee Member Date Ryan Nielson, Committee Member Date Stephen Turcotte, Department Chair 1 ABSTRACT SURFACE DISTRIBUTION AND X-RAY EMISSION FROM SCOTCH TAPE Kelly McGuire Department of Physics Bachelor of Physics Triboluminescence is an optical phenomenon in which light is generated when certain materials are pulled apart, ripped or rubbed, and through the breaking of chemical bonds. This observable effect is not fully understood; however, a few strongly supported hypotheses are being developed to model the triboluminescent event. It is believed that the separation and ionization of electrical charges is the foundation for the creation of the observed light and x-rays (figure1). FIG. 1 Triboluminescent Light Time dependence of x-ray production and physical surface distribution was the primary focus of my research. This research will help in the development and support of current hypotheses, and may become the foundation for other theories in the future. Other research teams such as Putterman’s UCLA group believe that finding a definite mechanism for the x-ray emission of this type will allow them to harness the energy more efficiently, which in turn will be used in applications such as medical devices 2 to destroy tumors with bursts of x-rays. -
Phosphors and Phosphorus in Early Danish Natural Philosophy
Phosphors and Phosphorus in Early Danish Natural Philosophy by HELGE KRAGH Historisk-filosofiske Meddelelser 88 Det Kongelige Danske Videnskabernes Selskab The Royal Danish Academy of Sciences and Letters Commission Agent: C.A. Reitzel Det Kongelige Danske Videnskabernes Selskab udgiver følgende publikationsrækker: The Royal Danish Academy of Sciences and Letters issues the following series of publications: Authorized Abbreviations Historisk-filosofiske Meddelelser, 8 Hist.Fil.Medd.Dan.Vid.Selsk. (printed area 175 x 104 mm, 2700 units) Historisk-filosofiske Skrifter, 4 Hist.Filos.Skr.Dan.Vid.Selsk. (History, Philosophy, Philology, (printed area 2 columns, Archaeology, Art History) each 199 x 77 mm, 2100 units) Matematisk-fysiske Meddelelser, 8 Mat.Fys.Medd.Dan.Vid.Selsk. (Mathematics, Physics, (printed area 180 x 126 mm, 3360 units) Chemistry, Astronomy, Geology) Biologiske Skrifter, 4 Biol.Skr.Dan.Vid.Sel.sk. (Botany, Zoology, Palaeontology, (printed area 2 columns, General Biology) each 199 x 77 mm, 2100 units) Oversigt, Annual Report, 8 Overs.Dan. Vid.Selsk. The Academy invites original papers that contribute significantly to research carried on in Denmark. Foreign contributions are accepted from temporary residents in Denmark, participants in a joint project involving Danish researchers, or those in discussion with Danish contributors. Instructions to Authors Manuscripts from contributors who are not members of the Academy will be refereed by two members of the Academy. Authors of papers accepted for publication will receive galley proofs and page proofs; these should be returned promptly to the editor. Corrections other than of printer’s errors will be charged to the author(s) insofar as their costs exceeds 15% of the cost of typesetting. -
Light Producing Sugar
LOVEFOOD LOVE SCIENCE 02: light producing sugar LOVE FOOD LOVE SCIENCE: Light-producing sugar What you need: • sugar cubes • pliers • a very, very dark room What to do: For this experiment, you will be crushing sugar in the dark • Place your pliers and lumps of sugar where you can easily find them in the dark (it may even be worthwhile to practice crushing sugar before you switch off the lights) • Turn off the light and wait at least two minutes – be patient, your eyes need time to adjust to the 02 darkness • Carefully crush a lump of sugar in your pliers • Watch carefully... What you may notice: Hopefully, you should see little flashes of blue light as you crush the sugar The science behind it all: The phenomenon you This energy builds and builds are witnessing is called until you let it go and the rubber Beyond the science: triboluminescence. band shoots back, releasing all When you crush a lump of the energy that it took to stretch Triboluminescence is alteration of electric charge sugar, you are fracturing sugar it in the first place. This is very related to piezoelectricity, distribution when the molecule crystals. Although the sugar similar to what’s happening with the ability of certain materials is squeezed or stretched. molecules form an orderly the sugar crystals. to produce electricity when Asymmetric, piezoelectric arrangement, the crystals are under mechanical stress materials are more likely to slightly asymmetric. This allows When the two charges (squeezed, rubbed, etc) due be triboluminescent than positive and negative charges to eventually shoot back together to the separation of positive symmetric ones.