In the Pipeline

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Advertising Index March 2008 In The Pipeline he experimental treatment for metastic melanoma elesclomol has been Advertiser. Page Tgranted orphan drug status by the FDA, GlaxoSmithKline and Synta Pharmaceuticals announced. Elesclomol is a novel, injectable, drug candi- Abbott Laboratories. 2-5 date that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death, the companies explain. www.abbott.com In a phase 2b clinical trial, 81 patients were randomly assigned in a 2:1 (847) 937-6100 ratio to receive elesclomol in combination with paclitaxel versus paclitaxel alone. Treatment was once per week for three weeks, followed by one week with no treatment. Patient population included only Stage IV patients with Allergan . 13 one or no prior chemotherapies and no brain metastases. The primary end- www.allergan.com/site/skin point was progression-free survival (PFS), defined as the time from patient (714) 246-4500 randomization until the earliest sign of disease progression or death. Results indicated that the addition of elesclomol doubled median PFS, from 1.8 to 3.7 months, and more than doubled the percentage of patients DUSA Pharmaceuticals. 48-50 free of progression at six months, from 15 percent to 35 percent. The haz- ard ratio was 0.58, indicating a 42 percent reduction in risk of disease pro- www.dusapharma.com gression for patients receiving the combination treatment versus patients (877) 533-3872 receiving control treatment. Patients randomized to receive elesclomol plus paclitaxel experienced a substantially longer median survival com- pared to patients who initially received paclitaxel alone. Galderma. 19-20 Adverse events including hypoaesthesia, neutropenia, stomatitis, www.galdermausa.com arthralgia, and fatigue occurred with higher incidence in the elesclomol (817) 961-5000 plus paclitaxel group, though incidences of adverse evens were generally comparable between the two groups. Moreover, safety data were consis- tent with pooled safety analyses from all trials in which patients received Graceway Pharmaceuticals. 9-11 elesclomol in combination with paclitaxel. The FDA's decision allows an accelerated clinical trials program for www.gracewaypharma.com elesclomol because the patient population is small and there are currently (800) 447-4537 no adequate treatments for metastatic melanoma, GSK and Synta note. I Merz . 34-35 www.merz.com (888) 637-9872 Stiefel. 54 www.stiefel.com/USA (888) 784-3338 For advertising inquiries, please contact Tom Gangemi, Publisher (610) 238-9052, ext. 11 or [email protected].

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Experimental modeling and novel therapeutic strategies in melanoma brain metastasis Terje Sundstrøm Dissertation for the degree of philosophiae doctor (PhD) University of Bergen, Norway 2015 Dissertation date: June 9th 2015 LIST OF ABBREVIATIONS 3D 3-dimensional 5-ALA 5-aminolevulinic acid AAAS American Association for the Advancement of Science ACT Adoptive cell transfer ADC Apparent diffusion coefficient AJCC American Joint Committee on Cancer AKT Protein kinase B ALK Anaplastic lymphoma kinase APC Antigen-presenting cell APOE Apolipoprotein-E ATP Adenosine triphosphate B7-H3 B7 homolog 3 BBB Blood-brain barrier BCL2A1 Bcl-2-related protein A1 bFGF Basic fibroblast growth factor BLI Bioluminescence imaging BRAF Serine/threonine-protein kinase B-raf BRMS1 Breast cancer metastasis-suppressor 1 BTB Blood-tumor barrier CI (Mitochondrial) Complex I CC22 Chemokine (C-C motif) ligand 22 CD44v6 CD44 splicing variant 6 CDK4 Cyclin-dependent kinase 4 CDKN2A p16INK4A inhibitor of CDK4 cMAP Connectivity Map CNS Central nervous system COT Serine/threonine kinase Cot CRAF RAF proto-oncogene serine/threonine-protein kinase CT Computed tomography CTLA4 Cytotoxic T-lymphocyte-associated protein 4 CXCR4 C-X-C chemokine receptor type 4 2 Da Dalton (unit) DNA Deoxyribonucleic acid DWI Diffusion weighted imaging ECM Extracranial metastases EDNRB Endothelin receptor B EFSA European Foods Safety Authority EGFR Epidermal growth factor receptor ER Estrogen receptor ERBB2 Receptor tyrosine-protein kinase erbB-2 ERK Extracellular signal-regulated kinase ET3 Endothelin-3
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Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer
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Thesis Title Goes Here
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