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We Stand for Children Children’s Research Institute We Stand for Children. 2013 Academic Annual Report Vision Children’s National Health System aspires to be a top five academic pediatric medical center that is recognized as leading the quest to prevent or cure many of childhood’s most serious and prevalent disorders. We will achieve this vision through a unique collaboration between clinical and research programs, innovative educational programs, enhanced academic partnerships, improved infrastructure, and a stable base of financial support. Through this approach, our role as a national and international leader in the research and treatment of childhood diseases will be significantly strengthened. On the cover: Astroglia are the star shaped cells that make up the white matter in the brain and are now recognized as important regulators of growth and signaling of the neurons. Change in their cytoplasmic calcium is central to their ability to sense and respond to the signals from neurons and other brain cells. Sequential pseudocolored images are shown for a pair of astroglial cells labeled with calcium-sensitive dye and then treated with an analogue of the brain’s main excitatory neurotransmitter glutamate. Head 1 We Stand for Children. Children’s Research Institute | 2013 Academic Annual Report Table of Contents 2 From the Directors 4 CRI Leadership 5 Children’s National Hosts Symposium on Medical Device Development 6 Understanding the Brain through Magnetic Resonance Imaging (MRI) 8 CRI Study Shows Value of Dads’ Involvement with Infants of Teen Moms 9 Noted Cell Therapy Expert Joins Children’s Research Institute 01 2013 Research Funding 11 Philanthropy 71 Clinical and Translational Science Institute at Children’s National (CTSI-CN) 91 Center for Cancer and Immunology Research 31 Center for Genetic Medicine Research 94 Center for Neuroscience Research 95 Center for Translational Science 17 Sheikh Zayed Institute for Pediatric Surgical Innovation 83 Academic Affairs 78 Office of Medical Education 98 Selected NIH Grants and Other Awards Children’s National 2013 Academic Annual Report | 1 From the Directors his 2013 Children’s Research Institute (CRI) The Center for Cancer and Immunology Research saw a annual report represents a summary of research transformational change in its vision and expansion of its T and educational programs and the respective programs with new leaders joining CRI: Dr. Yang Liu and accomplishments of our dedicated faculty and staff. Major Dr. Pan Zheng in basic science of cancer and immunity, Dr. advances have been made by all five research centers with Yuan Zhu in Neurofibromatosis research and Dr. Catherine high impact scientific discoveries and successful grant Bollard in cellular immune therapy research. funding both from federal and non-federal sources. The Center for Genetic Medicine Research under the In spite of strong national competition for scarce research leadership of Dr. Eric Hoffman continued its many dollars, our National Institutes of Health grant portfolio translational research projects in common and rare diseases currently approximates $42 million of the total CRI research and to provide core services to scientists from across CRI. funding of approximately $75 million, an increase of 8 One such project is the development of steroid analogs of percent from fiscal year 2012. In 2013, CRI submitted great promise for steroid therapy without their limiting approximately 288 grants (167 federal and 121 non-federal) serious side effects. and saw a success rate of 32 percent federal grants and 32 percent for non-federal grants (based on the first six months The Center for Neuroscience under the leadership of Dr. of FY13), continuously higher than the national average. Vittorio Gallo expanded its research program in fetal Our pilot grant program resulted in 20 percent conversion medicine with the recruitment of Dr. Anna Penn who works to extramural funding and our bridge funding program on placental factors involved in fetal brain development. continued to have a favorable return on investment. The Drs. Scafidi and Gallo published in the journal Nature that above success rate was in part due to our expanding and epidermal growth factor can mitigate neonatal brain injury, efficient grant enhancement program in the CTSI-CN led a finding that can hopefully be translated to improve the by Dr. Peter Scheidt. outcome of cerebral palsy in premature infants. CHILDREN’S RESEARCH INSTITUTE CENTERS Sheikh Zayed Cancer and Neuroscience Genetic Medicine Institute for Center for Immunology Research Research Pediatric Translational Science Research Surgical Innovation Clinical and Translational Science Institute at Children’s National Diana L. and Joseph E. Stephen A. Neuroscience Heart, Lung, Cancer and Robert, Jr., Hospital-Based Goldberg and Behavioral and Kidney Blood Disorders Center for Specialties Center for Medicine Disease Surgical Care Community Pediatric Health CHILDREN’S NATIONAL CLINICAL CENTERS 2 | Children’s National 2013 Academic Annual Report Mission Children’s Research Institute will conduct novel basic, translational, clinical, and community research and education programs within Children’s National Health System that improve the well-being of children throughout their lives. The Center for Translational Science and the Clinical and Translational Science Institute at Children’s National under the leadership of Dr. Lisa Guay-Woodford expanded its investigator initiated research programs and the reach of its Mendel Tuchman, MD NIH-funded consortia including new projects in pediatric Chief Research Officer, clinical pharmacology asthma and HIV/AIDS. Under Children’s National Health System Dr. Pam Hinds nursing research continued to thrive with Scientific Director, additional investigators and projects. Children’s Research Institute The Sheikh Zayed Institute for Pediatric Surgical Innovation under the leadership of Dr. Peter Kim was awarded a highly competitive Pediatric Device Consortia Grant (P50) by the U.S. Food and Drug Administration to develop a consortium for pediatric device innovation in the national Mark L. Batshaw, MD capital becoming a leader in pediatric bioengineering. Chief Academic Officer, Our educational programs continued to excel. Forty Physician-in-Chief, new pediatric interns from 34 different medical schools Children’s National Health System from around the world, selected from 2,400 applicants, Director, matriculated at Children’s National and our pediatric Children’s Research Institute residency program has expanded and now trains a total of 117 residents under the leadership of Drs. Mary Ottolini and Dewesh Agrawal. We celebrated Children’s academic accomplishments during Research and Education Week in which Dr. Francis Collins, Director of the NIH, was the keynote speaker. Our programs were represented by 249 posters and 26 awards in several research and education categories. Four faculty members were elected to the Society for Pediatric Research/ American Pediatric Society. This has been another successful year of enhancement of our academic programs credited to the wonderful faculty and staff with whom we have the privilege to work. ■ Children’s National 2013 Academic Annual Report | 3 CRI Leadership Senior Leadership Executive Directors Kurt D. Newman, MD Kolaleh Eskandanian, PhD, MBA, PMP President and CEO Executive Director, Sheikh Zayed Institute for Pediatric Mark L. Batshaw, MD Surgical Innovation Director and Chief Academic Officer Kerstin Hildebrandt, MSHS Physician-in-Chief Executive Director, Operations and Regulatory Affairs Mendel Tuchman, MD Carmen Mendez, MBA Chief Research Officer Executive Director, Grants, Contracts, and Finance Scientific Director Naomi Luban, MD Board of Directors Vice Chair for Faculty Affairs Mary Ottolini, MD Mark L. Batshaw, MD Vice Chair for Education Kevin M. Fickenscher, MD, PhD Fred T. Goldberg, Jr. (Vice Chairman) Center Directors and Associate Directors Ada Sue Hinshaw, PhD Yang Liu, PhD Evan Jones Director, Center for Cancer and Immunology Research Scott Koenig, MD, PhD (Chairman) Jeffrey Dome, MD Alan I. Leshner, PhD Associate Director, Center for Cancer Kurt D. Newman, MD (President) and Immunology Research Mary Alice O’Malley Yuan Zhu, PhD Associate Director, Center for Cancer Jutta K. Parsons and Immunology Research David Schlitz Eric Hoffman, PhD Jay Schnitzer, MD, PhD Director, Center for Genetic Medicine Research Elizabeth A. Singer Kanneboyina Nagaraju, DVM, PhD Robert E. Taylor, MD, PhD Associate Director, Center for Genetic Medicine Research Joel Wood Vittorio Gallo, PhD Director, Center for Neuroscience Research William D. Gaillard, MD Associate Director, Center for Neuroscience Research Lisa M. Guay-Woodford, MD Director, Center for Translational Science and the Clinical and Translational Science Institute at Children’s National Pamela S. Hinds, PhD, RN, FAAN Associate Director, Center for Translational Science Peter C.W. Kim, MD, CM, PhD Vice President, Sheikh Zayed Institute for Pediatric Surgical Innovation 4 | Children’s National 2013 Academic Annual Report Children’s National Hosts Symposium on Medical Device Development n June 2013, the Sheikh Zayed Institute for Pediatric Taking advantage of the unprecedented caliber of attendees, Surgical Innovation at Children’s National hosted the the day after the symposium the institute hosted a closed- I First Annual Pediatric Surgical Innovation Symposium. door session to gather key recommendations and reach The symposium was convened to address critical issues consensus
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