DRUGS POTENTIALLY AFFECTING MIBG UPTAKE rev. 26 Oct 2009 EXCLUDED MEDICATIONS DUE TO DRUG INTERACTIONS WITH ULTRATRACE I-131-MIBG Drug Class Generic Drug Name Within Class Branded Name Checked Cocaine Cocaine □ Dexmethylphenidate Focalin, Focalin XR □ CNS Stimulants (Norepinephrine Reuptake Inhibitor) Methylphenidate Concerta, Metadate CD, Metadate ER, Methylin, Methylin ER, Ritalin, Ritalin LA, □ Ritalin-SR, Daytrana benzphetamine Didrex □

Diethylpropion Tenuate, Tenuate Dospan □ Phendimetrazine Adipost, Anorex-SR, Appecon, Bontril PDM, Bontril Slow Release, Melfiat, Obezine, CNS Stimulants (Norepinephrine and Dopamine Reuptake Inhibitor) □ Phendiet, Plegine, Prelu-2, Statobex Phenteramine Adipex-P, Ionamin, Obenix, Oby-Cap, Teramine, Zantryl □ Sibutramine Meridia □ Isocarboxazid Marplan □ Linezolid Zyvox □ Phenelzine Nardil □ Monoamine Oxidase Inhibitors selegiline (MAOa at doses > 15 mg qd) Eldepryl, Zelapar, Carbex, Atapryl, Jumex, Selgene, Emsam □ Tranylcypromine Parnate □

Reserpine Generic only. No brands available. Central Monoamine Depleting Agent □

labetolol Non-select Beta Adrenergic Blocking Agents Normodyne, Trandate □ Opiod Analagesic Tramadol Ultram, Ultram ER □ Pseudoephedrine Chlor Trimeton Nasal Decongestant, Contac Cold, Drixoral Decongestant Non- Drowsy, Elixsure Decongestant, Entex, Genaphed, Kid Kare Drops, Nasofed, Sympathomimetics : Direct Alpha 1 Agonist (found in cough/cold preps) Seudotabs, Silfedrine, Sudafed, Sudodrin, SudoGest, Suphedrin, Triaminic Softchews □ Allergy Congestion, Unifed amphetamine (various salts) □ Dextroamphetamine Dexedrine, Dexedrine Spansule, Dextrostat, ProCentra □ Sympathomimetics: Amphetamines methamphetamine (desoxyephedrine) Desoxyn, Desoxyn Gradumet □ Lisdexamfetamine Vyvanse □ Phenylephrine Ah-Chew D, Dimetapp Cold Drops, Lusonal, Nasop, Nasop12, PediaCare Children's Decongestant, Phenyl-T, Sudafed PE, Sudafed PE Children's Nasal Decongestant, Sudafed PE Quick Dissolve, Sudogest PE, Triaminic Thin Strips Cold,Neo- Sympathomimetics: Alpha 1 Adrenergic Agonists (found in cough and Synephrine, Despec-SF, Sudafed PE Extra Strength, Triaminic Thin Strips Nasal □ cold preps) Congestion, Triaminic Toddler Congestion Thin Strips, Triaminic Thin Strips Infant Decongestant, Dimetapp Children's Cold & Allergy

Ephedrine Any meds containing Ephedrine □ Phenylpropanolamine Acutrim 16 Hour, Acutrim II, Maximum Strength, Acutrim Late Day, Control, Dexatrim, Sympathomimetic: Alpha/Beta Agonist Empro, Mega-Trim, Phenyldrine, Propagest, Propan, Rhindecon, Westrim, Westrim LA, Acutrim II, Maximum Strength, Dexatrim Caffeine Free □ APPENDIX III (continued) EXCLUDED MEDICATIONS DUE TO DRUG INTERACTIONS WITH ULTRATRACE I-131-MIBG Drug Class Generic Drug Name Within Class Branded Name Checked I-desoxyephedrine □ naphazoline Clear Eyes ACR, VasoClear A □ Oxymetazoline Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four- Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A- Day,12 Hour Nasal, Zicam Extreme Congestion Relief, Zicam Sinus Relief, 12 Hour Nasal Decongestant, Neo-Synephrine 12 Hour Extra Moisturizing, Afrin No Drip Sympathomimetics: Alpha 2 Adrenergic Agonists (found in eye drops and Severe Congestion, Mucinex Moisture Smart, Mucinex Full Force, Afrin Pump Mist, □ nasal sprays) Afrin Extra Moisturizing, Afrin Severe Congestion, Afrin Severe Congestion NoDrip, Afrin NoDrip Extra Moisturizing, Afrin All Night NoDrip, Afrin No Drip Sinus, Sudafed OM Sinus Congestion, Sudafed OM Sinus Cold, Nasal Mist

Propylhexedrine Benzedrex □ Tetrahydrozoline Visine A.C., Irritation & Redness Relief □ Xylometazoline Otrivin, Triaminic Decongestant □ Amitriptyline Vanatrip, Elavil, Endep □ Amoxapine Asendin □ Atomoxetine Strattera □ Bupropion Budep rion, Wellbutrin, Wellbutrin SR, Wellbutrin XL , Zyban □ Clomipramine Anafranil □ Desipramine Norpramin □ Desvenlafaxine Pristiq □ Doxepin Adapin, Sinequan □ Tricyclic Antidepressants and Norepinephrine Reuptake Inhibitors Duloxetine Cymbalta □ Imipramine Tofranil, Tofranil-PM □ Maprotiline Ludiomil □ Mirtazapine Remeron, Remeron SolTab □ Nefazodone Serzone □ Nortriptyline Pamelor, Aventyl HCl □ Protriptyline Vivactil □ Trimipramine Surmontil □ Venlafaxine Effexor, Effexor XR □ Ephedra ma huang □ ma huang Ephedra □ St John’s Wort St. John's wort , klamath weed , John's wort , amber touch-and-heal , goatweed , rosin *Herbal therapy (Inhibits Reuptake of One or More; NE, 5HT, DA) □ rose , and millepertuis Yohimbine Erex, Testomar, Yocon, Yohimar, Yohimbe, Yohimex,Yoman, Actibine, Dayto-Himbin, □ Yovital, Aphrodyne, Mederek, Thybine *may consider avoiding all herbal therapy unless the mechanism of action is well established