Memory Dysfunction INTRODUCTION Distributed Brain Networks
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Memory Part 1: Overview
FUNCTIONAL VIGNETTE Memory Part 1: Overview F.D. Raslau, A.P. Klein, J.L. Ulmer, V. Mathews, and L.P. Mark common layman’s conception of memory is the simple stor- Aage and retrieval of learned information that often evokes comparison to a filing system. Our everyday experience of mem- ory, however, is in fact a complicated multifactorial process that consists of both conscious and unconscious components, and de- pends on the integration of a variety of information from distinct functional systems, each processing different types of information by different areas of the brain (substrates), while working in a concerted fashion.1-4 In other words, memory is not a singular process. It represents an integrated network of neurologic tasks and connections. In this light, memory may evoke comparison with an orchestra composed of many different instruments, each making different sounds and responsible for different parts of the score, but when played together in the proper coordinated fash- ion, making an integrated musical experience that is greater than the simple sum of the individual instruments. Memory consists of 2 broad categories (Fig 1): short- and long-term memory.5 Short-term memory is also called work- ing memory. Long-term memory can be further divided into FIG 1. Classification of memory. declarative and nondeclarative memory. These are also re- ferred to as explicit/conscious and implicit/unconscious mem- heard (priming), and salivating when you see a favorite food ory, respectively. Declarative or explicit memory consists of (conditioning). episodic (events) and semantic (facts) memory. Nondeclara- The process of memory is dynamic with continual change over tive or implicit memory consists of priming, skill learning, and time.5 Memory traces are initially formed as a series of connections conditioning. -
Auditory Feedback Blocks Memory Benefits of Cueing During Sleep
ARTICLE Received 26 Feb 2015 | Accepted 25 Sep 2015 | Published 28 Oct 2015 DOI: 10.1038/ncomms9729 OPEN Auditory feedback blocks memory benefits of cueing during sleep Thomas Schreiner1,2, Mick Lehmann1,3 & Bjo¨rn Rasch1,2,4 It is now widely accepted that re-exposure to memory cues during sleep reactivates memories and can improve later recall. However, the underlying mechanisms are still unknown. As reactivation during wakefulness renders memories sensitive to updating, it remains an intriguing question whether reactivated memories during sleep also become susceptible to incorporating further information after the cue. Here we show that the memory benefits of cueing Dutch vocabulary during sleep are in fact completely blocked when memory cues are directly followed by either correct or conflicting auditory feedback, or a pure tone. In addition, immediate (but not delayed) auditory stimulation abolishes the characteristic increases in oscillatory theta and spindle activity typically associated with successful reactivation during sleep as revealed by high-density electroencephalography. We conclude that plastic processes associated with theta and spindle oscillations occurring during a sensitive period immediately after the cue are necessary for stabilizing reactivated memory traces during sleep. 1 Department of Psychology, University of Zurich, 8050 Zurich, Switzerland. 2 Department of Psychology, University of Fribourg, 1701 Fribourg, Switzerland. 3 Psychiatric University Hospital Zurich, Clinic of Affective Disorders and General Psychiatry, 8032 Zurich, Switzerland. 4 Zurich Center for Interdisciplinary Sleep Research (ZiS), 8091 Zurich, Switzerland. Correspondence and requests for materials should be addressed to B.R. (email: [email protected]). NATURE COMMUNICATIONS | 6:8729 | DOI: 10.1038/ncomms9729 | www.nature.com/naturecommunications 1 & 2015 Macmillan Publishers Limited. -
Group Studies in Experimental Neuropsychology
C HAPTER 3 4 GROUP STUDIES IN EXPERIMENTAL NEUROPSYCHOLOGY Lesley K. Fellows WHY NEUROPSYCHOLOGY? individual differences in skull shape (explicitly thought to be a proxy for underlying brain structure) A fundamental assumption of neuropsychology, and in relation to individual differences in behavior. of cognitive neuroscience more generally, is that Complex traits like benevolence and wit were thus behavior has a biological basis—that it results from related to particular parts of the brain. Although the processes that are executed in the nervous system. methods are clearly flawed to the eye of the modern Following from this assumption, emotions, reader, the underlying concept of localization, that thoughts, percepts, and actions can be understood brain structure and function are related, had a major in neurobiological terms. This premise was impact on the development of clinical neurology and advanced by the philosophers of ancient Greece, of experimental neuropsychology. supported, in part, by observations of patients with The work of Broca, Wernicke, and other 19th- brain injury (Gross, 1995). The fact that damage to and early 20th-century neurologists illustrated how the brain could lead to paralysis, disorders of sensa- observation in clinical populations can (a) provide tion, or even disruptions of consciousness suggested insights into how a complex behavior (like lan- that this organ was the seat of such abilities, guage) can be segmented into simpler components although the broad claim that brain function under- (e.g., production and comprehension) and (b) how lies behavior was not without controversy over the such components can be related to specific regions centuries that followed (Crivellato & Ribatti, 2007). -
NEUROLINGUISTICS Valentina Bambini*
Jan-Ola Östman & Jef Verschueren Handbook of Pragmatics (2012) © 2012 John Benjamins Publishing Company. Not to be reproduced in any form without written permission from the publisher. NEUROLINGUISTICS Valentina Bambini* 1. Definition Neurolinguistics is the study of language-brain relations. Its final goal is the com- prehension and explanation of the neural bases for language knowledge and use. Neurolinguistics is by its nature an interdisciplinary enterprise, and straddles the borders between linguistics and other disciplines that are connected to the study of the mind/brain (mainly cognitive psychology, neuropsychology and cognitive neuroscience). When approached from the point of view of the neurosciences, neurolinguistics focuses on how the brain behaves in language processes, both in healthy and pathological conditions; conversely, from a linguistics standpoint, neu- rolinguistics aims at clarifying how language structures can be instantiated in the brain, i.e. how patterns and rules exhibited in human languages are represented and grounded in the brain. In addition, neurolinguistics has a fundamental clinical impact for assessment and treatment of patients suffering from aphasia and other language pathologies. The field was officially opened up by the nineteenth-century neurologist Paul Broca with his observations of the correlation between language disturbance and brain damage. Since then, over 100 years of investigation into the organization of language in the brain were based on a lesion-deficit approach, in a localizationist perspective. The significance of a brain area was deduced through observation of deficits following a lesion to that brain region, and the exact localization of the lesion was verified through post-mortem examination. The aphasiological era developed a functional model of language production and comprehension that highlighted the 2 Valentina Bambini role of frontal and temporal regions (and connections between them) in the left hemisphere, a model that has informed diagnosis and research up to date. -
Retrieval Practice: Which Factors Should Educators Pay Attention
ARTIGO DOI: http://dx.doi.org/10.1590/2175-35392020220284 Elocid - e220284 PRÁTICA DE LEMBRAR: A QUAIS FATORES OS EDUCADORES DEVEM SE ATENTAR? Roberta Ekuni 1 ; Sabine Pompeia 2 RESUMO A prática de lembrar (retrieval practice) ou efeito da testagem (testing-effect) é uma estratégia de estudo que envolve tentar lembrar informações às quais fomos anteriormente expostos. Embora essa prática aumente o tempo de retenção de informações comparada às formas tradicionais de estudar, dentre várias outras vantagens com ampla evidência científica, essa estratégia não costuma ser a mais usada entre alunos. Educadores devem, assim, auxiliar estudantes a utilizarem essa estratégia em seu cotidiano. Com o intuito de otimizar sua aplicabilidade, o presente artigo discute quais fatores interferem nessa prática, incluindo: a importância de feedback, a forma com que a prática de lembrar é realizada e o formato de resposta dos alunos, o número de repetições de tentativas de recordar informações e o intervalo entre essas repetições. A apropriação do conhecimento sobre esses fatores influencia positivamente a implantação da técnica em sala de aula, promovendo assim uma educação baseada em evidências. Palavras-chave: processos cognitivos; aprendizagem; memória. Retrieval practice: which factors should educators pay attention to? ABSTRACT The retrieval practice or testing - effect, is a study technique that involves trying to remember information to which we were previously exposed. Although this practice increases the long term-retention of information compared to traditional study techniques, among several other advantages with ample scientific evidence, this strategy is not usually the most used among students. Educators should help students to use this technique in their daily lives. -
Neurobehavioral Anatomy, Third Edition
CONTENTS Preface to the Third Edition xi Chapter One: BEHAVIOR AND THE BRAIN 1 The Mind-Brain Problem 2 General Features of Brain Anatomy 5 The Excesses of Phrenology 13 Behavioral Neurology 14 References 21 Chapter Two: MENTAL STATUS EVALUATION 25 History and Interview 25 Mental Status Examination 28 Standardized Mental Status Testing 40 References 44 vii viii CO N TE N TS Chapter Three: DISORDERS OF AROUSAL AND ATTENTION 49 Arousal Dysfunction 51 Attentional Dysfunction 54 References 60 Chapter Four: MEMORY DISORDERS 63 Inattention 64 Amnesia 65 Remote Memory Loss 71 References 72 Chapter Five: LANGUAGE DISORDERS 75 Cerebral Dominance and Handedness 78 Aphasia 80 Alexia 86 Agraphia 89 References 90 Chapter Six: APRAXIA 95 Limb Kinetic Apraxia 97 Ideomotor Apraxia 97 Ideational Apraxia 101 References 102 Chapter Seven: AGNOSIA 105 Visual Agnosia 107 Auditory Agnosia 112 Tactile Agnosia 113 References 114 Chapter Eight: RIGHT HEMISPHERE SYNDROMES 119 Constructional Apraxia 120 Neglect 121 Spatial Disorientation 124 Dressing Apraxia 124 Aprosody 125 CO N TE N TS ix Amusia 127 Emotional Disorders 129 References 134 Chapter Nine: TEMPORAL LOBE SYNDROMES 139 The Limbic System 140 Temporal Lobe Epilepsy 143 Psychosis in Temporal Lobe Epilepsy 147 Temporal Lobe Epilepsy Personality 150 References 155 Chapter Ten: FRONTAL LOBE SYNDROMES 159 Orbitofrontal Syndrome 163 Dorsolateral Syndrome 166 Medial Frontal Syndrome 167 Functions of the Frontal Lobes 168 References 172 Chapter Eleven: TRAUMATIC BRAIN INJURY 175 Focal Lesions 176 Diffuse Lesions 178 References 185 Chapter Twelve: DEMENTIA 189 Cortical Dementias 194 Subcortical Dementias 200 White Matter Dementias 205 Mixed Dementias 214 References 218 Epilogue 227 Glossary of Neurobehavioral Terms 229 Index 241 C H AP T E R O N E BEHAVIOR AND THE BRAIN Human behavior has an enduring appeal. -
Fmri Brain-Computer Interface: a Tool for Neuroscientific Research And
Hindawi Publishing Corporation Computational Intelligence and Neuroscience Volume 2007, Article ID 25487, 10 pages doi:10.1155/2007/25487 Review Article fMRI Brain-Computer Interface: A Tool for Neuroscientific Research and Treatment Ranganatha Sitaram,1 Andrea Caria,1 Ralf Veit,1, 2 Tilman Gaber,1, 2 Giuseppina Rota,1, 3 Andrea Kuebler,1 and Niels Birbaumer1, 4 1 Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University of Tubingen,¨ 72074 Tubingen,¨ Germany 2 Max Planck Institute for Biological Cybernetics, P.O. Box 21 69, 72076 Tubingen,¨ Germany 3 Institute for Natural Language Processing, University of Stuttgart, 70174 Stuttgart, Germany 4 National Institute of Health (NIH), NINDS, Human Cortical Physiology, Bethesda, MD 20892-1428, USA Correspondence should be addressed to Ranganatha Sitaram, [email protected] Received 28 February 2007; Revised 2 August 2007; Accepted 18 September 2007 Recommended by Shangkai Gao Brain-computer interfaces based on functional magnetic resonance imaging (fMRI-BCI) allow volitional control of anatomically specific regions of the brain. Technological advancement in higher field MRI scanners, fast data acquisition sequences, prepro- cessing algorithms, and robust statistical analysis are anticipated to make fMRI-BCI more widely available and applicable. This noninvasive technique could potentially complement the traditional neuroscientific experimental methods by varying the activity of the neural substrates of a region of interest as an independent variable to study its effects on behavior. If the neurobiological basis of a disorder (e.g., chronic pain, motor diseases, psychopathy, social phobia, depression) is known in terms of abnormal activity in certain regions of the brain, fMRI-BCI can be targeted to modify activity in those regions with high specificity for treatment. -
Certification Examination in Neurology
CERTIFICATION EXAMINATION IN NEUROLOGY The American Board of Psychiatry and Neurology, Inc. (ABPN) has issued new, two- dimensional content specifications for the psychiatry, neurology and child neurology certification examinations. Questions for the September 2017 psychiatry, neurology and child neurology certification examinations will conform to these new content specifications. Within the two-dimensional format, one dimension is comprised of disorders and topics while the other is comprised of competencies and mechanisms that cut across the various disorders of the first dimension. By design, the two dimensions are interrelated and not independent of each other. All of the questions on the examination will fall into one of the disorders/topics and will be aligned with a competency/mechanism. For example, an item on substance use could focus on treatment, or it could focus on systems-based practice. The psychiatry, neurology and child neurology content specifications can be accessed from the specialty certification section of our website. Candidates should use the new detailed content specifications as a guide to preparing for a certification examination. Scores for these examinations will be reported in a standardized format rather than the previous percent correct format. Following these three certification examinations in September 2017, future examinations given by the ABPN will gradually conform to the new two-dimensional content specification starting in 2018. The American Board of Psychiatry and Neurology, Inc. is a not-for-profit corporation dedicated to serving the public interest and the professions of psychiatry and neurology by promoting excellence in practice through certification and maintenance of certification processes. For more information, please contact us at [email protected] or visit our website at www.abpn.com . -
Priming and the Brain Review
Neuron, Vol. 20, 185±195, February, 1998, Copyright 1998 by Cell Press Priming and the Brain Review Daniel L. Schacter*§ and Randy L. Buckner²³ minutes to several hours, subjects are given three-letter *Department of Psychology word stems with multiple possible completions and are Harvard University asked to complete each stem with the first word that Cambridge, Massachusetts 02138 comes to mind (e.g., mot___ for the target word ªmotelº). ² Department of Psychology Priming occurs when subjects complete the stem with Washington University a designated target completion more often for words St. Louis, Missouri 63130 that had been studied earlier than for words that were ³ MGH-NMR Center not studied previously. In a related kind of experiment, Charlestown, Massachusetts 02129 subjects study a list of words and are later given a word identification test, where words are flashed briefly (e.g., Introduction for 35 ms) and subjects attempt to identify them. Priming occurs when subjects identify more previously studied Research in cognitive psychology, neuropsychology, words than nonstudied words. Similar kinds of tasks and neuroscience has converged recently on the idea have been developed for examining priming of numer- that memory is composed of dissociable forms and sys- ous different types of stimuli, including pseudowords tems (Squire, 1992; Roediger and McDermott, 1993; (Keane et al., 1995; Bowers, 1996), familiar and unfa- Schacter and Tulving, 1994; Willingham, 1997). This con- miliar objects (Biederman and Cooper, 1991; Srinivas, clusion has been based on experimental and theoretical 1993; Schacter et al., 1993b), visual patterns (Musen analyses of a variety of different phenomena of learning and Squire, 1992), and environmental sounds (Chiu and and memory. -
Behavioral Neurology Fellowship Core Curriculum
AMERICAN ACADEMY OF NEUROLOGY BEHAVIORAL NEUROLOGY FELLOWSHIP CORE CURRICULUM 1. INTRODUCTION AND DEFINITIONS The specialty of Behavioral Neurology focuses on clinical and pathological aspects of neural processes associated with mental activity, subsuming cognitive functions, emotional states, and social behavior. Historically, the principal emphasis of Behavioral Neurology has been to characterize the phenomenology and pathophysiology of intellectual disturbances in relation to brain dysfunction, clinical diagnosis, and treatment. Representative cognitive domains of interest include attention, memory, language, high-order perceptual processing, skilled motor activities, and "frontal" or "executive" cognitive functions (adaptive problem-solving operations, abstract conceptualization, insight, planning, and sequencing, among others). Advances in cognitive neuroscience afforded by functional brain imaging techniques, electrophysiological methods, and experimental cognitive neuropsychology have nurtured the ongoing evolution and growth of Behavioral Neurology as a neurological subspecialty. Applying advances in basic neuroscience research, Behavioral Neurology is expanding our understanding of the neurobiological bases of cognition, emotions and social behavior. Although Behavioral Neurology and neuropsychiatry share some common areas of interest, the two fields differ in their scope and fundamental approaches, which reflect larger differences between neurology and psychiatry. Behavioral Neurology encompasses three general types of clinical -
Two Components of Long-Term Memory
Two components of long-term memory Piotr A. woiniak1, Edward J. ~orzela6cz~k~ and Janusz A. ~urakowski~ 1.2~aboratoryof the Applied Research at the Department of Nursing and Health Sciences, Karol Marcinkowski Medical Academy, 79 Dqbrowski St., 60-529 Pornali Poland; 3~epartmentof Physics and Astronomy, University of Delaware, Newark, DE 19716, USA Abstract. The existence of two independent components of long-term memory has been demonstrated by the authors. The evidence has been derived from the authors' findings related to the optimum spacing of repetitions in paired-associate learning. The two components are sufficient to explain the optimum spacing of repetitions as well as the spacing effect. Although the molecular counterparts of the two components of memory are not known, the authors provide a collection of guidelines that might facilitate identification of such counterparts. to whom correspondence Key words: memory, learning, paired-associate learning, spacing should be addressed repetitions, synapse, long-term potentiation, spacing effect 302 P.A. Woiniak et al. It has been found in earlier research that the op- out the spacing effect, a large number of repetitions timum spacing of repetitions in paired-associate in a very short period of time might increase the op- learning, understood as the spacing which takes a timum inter-repetition interval to an excessive minimum number of repetitions to indefinitely value, far beyond the period in which the learned as- maintain a constant level of knowledge retention sociation is important for the conditioned individ- (e.g. 95%), can roughly be expressed using the fol- ual. lowing formulae (Woiniak and Gorzelanczyk Because of a deeply-rooted evolutionary signi- 1994). -
Mild Cognitive Impairment Douglas W
Mild Cognitive Normal Impairment (MCI) Mild Cognitive Impairment Douglas W. Scharre, MD Director, Division of Cognitive Neurology Ohio State University Dementia Dementia Definition • Syndrome of acquired persistent intellectual impairment • Persistent deficits in at least three of the following: Definitions 9 Memory 9 Language 9 Visuospatial 9 Personality or emotional state 9 Cognition • Resulting in impairment in Activities of Daily Living (ADL) 1 Mild Cognitive Impairment MCI Related (MCI) Definition Conditions • Definitions vary - be careful! AAMI: Age-Associated Memory Impairment • Petersen criteria • Non-disease, aging-related decline in – Memory complaint memory – Memory loss on testing greater that 1.5 standard • Diagnostic criteria are ambiguous deviations below normal for age • Complaints of memory loss more related – Other non-memory cognitive domains normal or to affect/personality than test scores mild deficits (language, visuospatial, executive, personality or emotional state) • Prevalence in the elderly varies from 18% up to 38% depending on the study – Mostly normal activities of daily living Barker et al. Br J Psychiatry 1995;167:642-8 Arch Neurol 1999;56:303-8 Hanninen et al. Age and Aging 1996;25:201-5 MCI Related MCI Related Conditions Conditions • Age-Associated Memory Impairment Benign Senescent Forgetfulness or Mild (AAMI) Memory Impairment (MMI) • Memory tests > 2 s.d. below normal age and • Benign Senile Forgetfulness or Mild education matched individuals Memory Impairment (MMI) • Normal non-memory cognitive domains