molecules Review The Therapeutic Potential of Psilocybin Henry Lowe 1,2,3,4, Ngeh Toyang 2,3 , Blair Steele 1,*, Henkel Valentine 1, Justin Grant 1,5, Amza Ali 1,5, Wilfred Ngwa 6 and Lorenzo Gordon 7 1 Biotech R & D Institute, University of the West Indies, Mona 99999, Jamaica;
[email protected] (H.L.);
[email protected] (H.V.);
[email protected] (J.G.);
[email protected] (A.A.) 2 Vilotos Pharmaceuticals Inc., Baltimore, MD 21202, USA; ngeh.toyang@flavocure.com 3 Flavocure Biotech Inc., Baltimore, MD 21202, USA 4 Institute of Human Virology (IHV), University of Maryland School of Medicine, Baltimore, MD 21202, USA 5 The Psyence Group, Toronto, ON M5J 2J1, Canada 6 Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;
[email protected] 7 Caribbean School of Medical Sciences, Kingston 99999, Jamaica;
[email protected] * Correspondence:
[email protected]; Tel.: +876-926-8502 Abstract: The psychedelic effects of some plants and fungi have been known and deliberately ex- ploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal source of naturally occurring psychedelics. The mushroom extract, psilocybin has historically been used as a psychedelic agent for religious and spiritual ceremonies, as well as a therapeutic option for neuropsychiatric conditions. Psychedelic use was largely associated with the “hippie” counterculture movement, which, in turn, resulted in a growing, and still lingering, negative stigmatization for psychedelics. As a result, in 1970, the U.S. government rescheduled psychedelics as Schedule 1 drugs, ultimately ending scientific research on psychedelics.