Balancing Science, Education and Biotechnology

2019 Report from the President FROM THE PRESIDENT

Dear Friends, Here are some of our

My challenge when I assumed the presidency of the MDI Biological accomplishments in Laboratory in 2018 was to chart a new course while maintaining a our areas of focus over connection with a scientific history that includes groundbreaking discoveries in fields ranging from oncology to kidney disease. the past year:

We are accomplishing this by strengthening the pillars – faculty, visiting scientists, education and biotechnology – that define the institution. • Faculty – Iain A. Drummond, Ph.D., will assume the position of senior scientist in September. Today, our scientists are identifying the regulatory mechanisms that He is currently associated with Harvard are critical to regeneration, which may help replace organs like the Medical School, Massachusetts General heart and kidney when they fail. They are also unraveling the secrets Hospital and the Harvard Stem Cell Institute. of longevity through their research on the cellular and molecular As senior scientist, he will provide the networks that govern aging. expertise, guidance and inspiration required At the same time, we are growing our education program and to build a critical mass of skilled faculty. translating science into cures through biotechnology. This progress is helping us realize our mission of educating the next generation of • Visiting scientist program – The summer scientists and transforming medicine through scientific discovery. visiting scientist program will be reinvigorated with the arrival of 15 investigators, four of We depend on the support of you, our donors, to advance our whom are members of the federally funded mission and thank you for all you have done to help us realize (Re)Building a Kidney (RBK) consortium, our goals. whose goal is to develop replacement kidney tissue. As the visiting scientist program grows, The theme uniting these pillars is the sharing of knowledge. While we look forward to becoming a center of RBK our distinguished legacy, beautiful setting and state-of-the-art collaborations. facilities all play a role in the discoveries that are being made here, it is the lively and robust exchange of ideas that makes the MDI • Education – We will explore a new way of Biological Laboratory what it is. looking at aging with a summer course and Like any structure, the pillars of an institution must rest on a firm follow-up fall symposium focused on the foundation. It is loyal supporters like you, who are committed to our interface between regeneration and aging. In vision, who make up the bedrock of that foundation. their cutting-edge approach and global appeal, these events will serve as templates for the We thank you for your generous support and invite you to join us series of “Acadia conferences” planned for on the exciting journey that lies ahead. 2020 and beyond.

•Biotechnology – We have already made With heartfelt gratitude, major contributions to the development of a robust science and technology sector in Maine through the establishment of the Maine Center for Biomedical Innovation and our role as an incubator for life sciences startups. Our Hermann Haller, M.D. plan is now to grow our incubator by adding President new life sciences companies.

2 | 2019 REPORT FROM THE PRESIDENT TOGETHER our research and science education programs made a major impact in 2018.

Thank you for being a partner in this critically important work.

citizen scientists from

countries

$ 12.3M in federal grants received students

faculty members and their research teams engaged in leading-edge regenerative medicine and aging research

3 | 2019 REPORT FROM THE PRESIDENT 2018 OPERATING EXPENSES AND FUNDING SOURCES (excluding depreciation)

Operating Expenses Funding Sources

6% Unrestricted Contributions Fundraising 3% 8% Foundations & Other Grants Management & General 20% 11% Reserves & Endowment

12% Program Fees & Other Income Educational Programs 23%

22% Federal Funding for Research Subawards Research 54%

41% Federal Grants & Contracts

STATEMENT OF FINANCIAL POSITION December 31, 2018

ASSETS 2018 LIABILITIES & NET ASSETS 2018

Cash & Cash Equivalents 3,013,515 Liabilities

Certificates of Deposit 4,832,443 Accounts Payable & Accrued Expenses 1,218,982

Receivables - Grants & Programs 1,263,202 Revenues & Grants Received in Advance 733,089

Receivables - Contributions & Pledges 742,642 Charitable Gift Annuities 6,519

Investments 6,573,404 Bonds Payable, net issuance costs 3,929,413

Land, Buildings & Equipment (net) 13,266,957 Total Liabilities 5,888,003

Total Assets 29,692,163 Net Assets Without Donor Restrictions 17,136,496

With Donor Restrictions 6,667,664

Total Net Assets 23,804,160

Total Liabilities & Net Assets 29,692,163

4 | 2019 REPORT FROM THE PRESIDENT STATEMENT OF ACTIVITIES December 31, 2018

OPERATING ACTIVITIES Without Donor With Donor Total Restrictions Restrictions Operating Support & Revenue Government Grants & Contracts 7,314,484 7,314,484 Contributions & Private Grants 1,467,715 582,245 2,049,960 Fees for Programs & Services 1,286,008 1,286,008 Investment Return Utilized 214,960 214,960 Interest & Other Income 103,633 7,018 110,651 Assets Released to Support Operations 14,375 (14,375) 0

Total Operating Support & Revenue 10,401,175 574,888 10,976,063

Operating Expenses Research 6,853,318 6,853,318 Educational Programs 2,977,113 2,977,113 Management & General 2,394,819 2,394,819 Fundraising 404,590 404,590 Total Operating Expenses 12,629,840 0 12,629,840 Change in Net Assets from Operating Activities (2,228,665) 574,888 (1,653,777)

NON-OPERATING ACTIVITIES Grants & Contributions for Capital Purposes 59,259 27,000 86,259 Assets Released for Capital Purposes 114,411 (114,411) 0 Gain (Loss) from Disposal of Assets (35,632) (35,632) Investment Return, Net of Amount Used 4,397 (370,617) (366,220)

Change in Net Assets from Non-Operating Activities 142,435 (458,028) (315,593)

Total Change in Net Assets (2,086,230) 116,860 (1,969,370) Net Assets, Beginning of Year 19,222,726 6,550,804 25,773,530

Net Assets, End of Year 17,136,496 6,667,664 23,804,160

The financial statements of the MDI Biological Laboratory for the fiscal year ending December 31, 2018 were audited by HMV, LLC and are available on our website or upon request. Adjustments were made to adopt FASB accounting standard ASU 2016-14 as required on January 1, 2018, and to better reflect GAAP standards for classification of Board Designated Funds and recording internal service fees.

5 | 2019 REPORT FROM THE PRESIDENT OUR DONORS

The MDI Biological Laboratory is extremely grateful to all of the donors who generously support our work. This list represents contributions made from January 1 to December 31, 2018. Every effort has been made to ensure the accuracy of our list. Our sincere apologies if any omissions or errors have occurred.

$100,000+ $2,500 – $4,999 Mr. Laurence B. Flood Cotswold Foundation Trust, Cheryl M. Coffin, M.D. and Ralph E. Topham Robert and Marthe Forrester Mr. and Mrs. I. Wistar Morris III Chuck* and Megan Dinsmore Mrs. L. Gordon Hamersley, Jr. Shelby Cullom Davis Charitable Fund John W. Bristol Fund of the Maine Community Dixie Hathaway Scott R. MacKenzie Foundation Foundation, Mr. and Mrs. Stephen B. Homer Drs. Robert* and Sondra Howe The Nature Conservancy, Maine Chapter Mrs. Caroline Huber $50,000 – $99,999 TH Maren/SK Fellner Fund of the Triangle Janet Stone Jones Foundation, Anonymous (2) Community Foundation Antoinette and Benjamin Brewster Mr. Alan W. Kornberg and Mr. Harold J. Koda Daphne* and Andrew Trotter Daniel Kniaz, M.D.* Ambassador and Mrs. Philip Lader $25,000 to $49,999 $1,000 – $2,499 Alice and Michael Lilly Long Cove Foundation, Inc., Jane* and Abass Alavi Mr. and Mrs. Lennart S. Lindegren Kristin and Michael Sant Vjera Bakovic, M.D. and Patricio Silva, M.D. Joan* and Fred Mansfield Ms. Eleanor A. Robbins Mrs. Robert O. Blake Maude and John March, Jr. Josephine A. Sollano, M.P.H., Dr.PH. Phoebe and Jim Boyer Stephen and Rebecca Milliken Alex C. Walker Foundation Anne W. Boylan* and John A. Cadwallader Farhan Panthaki Richard Bullock and Carol Woolman Brian and Leanne Pellerin $10,000 – $24,999 Lura* and Bill Clark Mr. and Mrs. R. Anderson Pew Peter J. Allen, M.D. and Ms. Sarah M. Hodder Design Group Collaborative, LLC Dr. and Mrs. Richard Pierson Dr. Edward J. Benz, Jr. and Dr. Margaret A. Vettese Sherrie S. Epstein Dr. Jerome G. Porush Dr. Thomas A. Boyd* and Mrs. Judith Boyd Mr. and Mrs. William G. Foulke, Jr. Mr. Marc A. Puntereri Phoebe C. Boyer* and Todd R. Snyder The Ganlee Fund Rockefeller Philanthropy Advisors, Mr. Terence C. Boylan* and Ms. Illiana van Meeteren Mr. Christiaan van Heerden David and Susan Rockefeller Ms. Ruth Cserr* and Dr. Robert Savell Gerrish H. Milliken Foundation Linda Seidel Field R & V Cushman Fund of the Community Dr. Patricia Hand and Mr. Victor Hand Julie and Henry Sharpe III Foundation of Jackson Hole Mr. and Mrs. James B. Harrison Slater Fund at Fidelity Charitable, Glenn Foundation for Medical Research Mr. John A. Hays* Dr. Alice D. Murphy Mr. and Mrs. Frank L. Hohmann III Becky and Doug Heden The U.S. Charitable Gift Trust, Dr. Lewis Kinter* and Ms. Terry Timberlake-Kinter Atwater Kent Foundation, Inc. Ms. Sara W. Pierce Mr. Alan B. Miller Allan and Joan Kleinman Robert Whitman and Jeffrey Munger The New York Community Trust, Mrs. Julius R. Krevans† Richard and Linda Wright Mr. and Mrs. Edward Hoffman Dr. Betty M. Massie Nancy and George† Putnam Warren Motley and Cynthia Saltzman $250 – $499 Frank Moya, M.D. Anonymous (2) $5,000 – $9,999 Elizabeth Myers, Ph.D.* and Evan Vosburgh, M.D. Judith T. and Robert P. Adelman Blum Halsey Scholars Fund Don and Heather Parker Mr.* and Mrs. Edward L. Barlow Devon Chatley and Christopher Sighinolfi* Denry Sato and Christine Chapline George P. Bayliss, M.D. Joanne and Paul Firstenberg Sharpe Family Foundation, Barbara S. Beltz Fog House Fund of the Fidelity Charitable Gift Fund Douglas and Ann Sharpe Vicky and Dick Bergman Edward & Verna Gerbic Family Foundation, Ms. Sarah A. Sharpe Anatole and Fani Besarab Mr. Peter Gerbic Ms. Kate Spokes Dr.* and Mrs. Mordecai P. Blaustein Mr. and Mrs. Richard C. Habermann Elizabeth and Bruce A. Stanton, Ph.D. Jerilyn Mitchell Bowers Drs. Elinor and Victor Kelmenson Mrs. Sohny Kang Strong The Chicago Community Foundation, Maine Community Foundation Samantha A. Vitagliano, D.M.D. James and Sally Kellogg Mr. and Mrs. Clement E. McGillicuddy Ms. Rosaleen M. Walsh Mr. and Mrs. Douglas Childs Oceans Ledge Fund of the Maine Community Drs. Mark Zeidel and Susan Freedman Sarah L. Clark Foundation, Dr. Dianna and Mr. Benjamin R. Emory Ms. Jan Coates Ms. Beth K. Pfeiffer $500 – $999 Dan and Kate Coit The Rhode Island Foundation, Anonymous (2) Brian and Sarah Cole Mr. and Mrs. Henry D. Sharpe, Jr. Ambassador and Mrs. Robert O. Blake, Jr. David and Kay Dawson Salsbury Cove Research Fund of the Maine Mr. and Mrs. Kevin P. A. Broderick Barbara and Jay* Farber Community Foundation The Florence V. Burden Foundation, W. Gregory and Linda Feero St. Louis Community Foundation, Ordway and Jean Burden Martha and Stein Feick Anonymous Judith Burger-Gossart* Gary and Giva Frashier Todd and Linda Crow Barbara Goldstein Jeanne L. DelSignore, M.D. Dr. Susanne R. Goldstein* and Mr. Jacob Blumenthal Drs. Michael* and Paula Duffy Dr. and Mrs. George Gorham Ms. Kate Ffolliott Ms. Tatiana Gott*

6 | 2019 REPORT FROM THE PRESIDENT OUR DONORS

Mr. and Mrs. Daniel Hanley Victor L. Schuster, M.D.* and Sandra K. Masur, Ph.D Ms. Ann Durkin Mike and Mary Hays Don and Rena McCrimmon Mr. Kurt A. Engleka Deborah L. Hendrie Janet Meryweather Mr. and Mrs. Russ Faeder Betsey Holtzmann Marjorie Millman David and Judith Fischer Ben and Lisa Humphreys Conrad Minnich* and Cynthia Herderick Mr.* and Mrs. Nicholas Franki Ken Mackie* Mr. and Mrs. Donal B. Murphy Mr. Michael Fraser David and Michele Marks Louisa and William V.P. Newlin Deborah S. Friedman, D.V.M. Roy A. McMorran Mary* and David* Opdyke Ms. Eve Galen* Chris and Heidi Murphy Lynn and John Orav Ms. Eleanor Gambell Charles Nicholson* and Jyoti Patel Nancy and Jim Patterson Mr. John D. Geddie Dr.* and Mrs. Robert D. Patterson Judith S. Perkins Dr.* and Mrs. Yale E. Goldman Bob and Susan Peck Mr. and Mrs. Charles L. Pugh Mrs. Lewis H. Gordon, Jr. William Penhallurick, M.D.* and Debra Chase, Ph.D. Nathaniel S. Putnam and Virginia Kozak Putnam John C. Harshbarger Nancy and Dan Poteet James A. Rawls, M.D.* Sarah and Chad* Hilty Robert and Joyce Preston Mr. and Mrs. John P. Reeves Ms. Berry Marshall Hoak Dean and Penny Read Dr.* and Mrs. Robert Rout Ann Humphrey and Aaron Glazer Elizabeth S. Roberts Mary Beth Rushton Adams* and Daniel R. Adams Ms. Ellen Kappes Dr. and Mrs. Derry Roopenian Drs. Jean M. and Joseph W. Sanger Dr. Karl Karnaky, Jr. and Ms. Sue Turner Bill and Pamela Ryckman Wilbur* and Anita Sawyer Ms. Helen Koch Robert Savage and Donna M. Fernandes, Ph.D. Arthur Shevchenko Anne Kozak Allyn* and Karen Seymour Loretta M. Shirey Dr. Eric R. Lacy* Nancy* and Mark Shumeyko Liv Rockefeller and Kenneth Shure Mr.* and Mrs. Edward LaRue Mary Douglass Ryan and Neil Smith* Erica Kirsners Silk and Adam Silk Kelly M. LaRue, Ph.D.* Ray* and Katharine Stanford David A. Spector, M.D.* Mr. Ivan B. Lee Rob Thomson and Lucy Hodder Jackie Stokes Leila Lituchy Dr.* and Mrs. Jerry Wacks Danielle and Mathew Stordy Vicki Losick, Ph.D. Mr. and Mrs. Bradford Wellman Dr.* and Mrs. Peter F. Straub Claudine Lurvey Susan and David Wheatland Dr. Kevin M. Ulmer* Stefanie Matteson William D. and Marilyn G. Wilson Peggy Crowell Walklet and Family Ms. Anne Mazlish Dr. Thomas L. Watt Donna V. Moore $100 – $249 Warwick and Mollie Wheeler Amy R. Morley Anonymous Michael and Sandra Widlitz Mr. Gene Nardi Elizabeth Allan and Brian Rahill Mr. and Mrs. Charles Wiggins Mrs. Stephen Pearson Peter Aronson and Marie Landry Charles Willand* and Sue DiMeo Brian and Trena Peisino Alan L. Baker Jacquelyn Wondergem Amy Pelletier Harold Bertrand Margot A. Woolley and Gerard F. Vasisko Mrs. Eben W. Pyne Dean and Mary Booher Torj and Kurt Wray Kris Reaman Douglas and Joan Brazinski Mr. and Mrs. Louis T. Zawislak Rita Redfield Roberta Brush Ms. Diana I. Rigg John and Jean Cameron $1 – $99 Sydney Roberts Rockefeller Clare Bates Congdon Anonymous (7) Hilda K. Roderick Drs. Gary and Abigail Conrad Curtis Abney Jarod A. Rollins, Ph.D. John and Marcie Correa Nancy Abuhaydar Maria and Bruce Runnegar Mr. Richard B. Cough Dr. Thorsten Althoff* Roger and Patricia Samuel John Emery and Guissou Dabiri Joe and Susan Anghinetti Ms. Diane C. Saunders* Dr. Megan Dethier* and Dr. David Duggins Dr. Siribhinya Benyajati* Jilliane Sawyer Michael* and Jan Duffey Amelia Bowen Roberta Sharp Dr. and Mrs. Richard R. Fox Ms. Pat Boyce Dr. Stefan Silbernagl Suzanne and Albert Frederick Dr. and Mrs. William C. Bromley Dr.* and Mrs. Thomas W. Simmons Mr. and Mrs. Richard G. Fuerst Dr. Cheryl Bunker* Ms. Christine Smith* Rev. and Mrs. Allen R. German Emily* and Dan Burke Dr. Marshall Smith and Mrs. Teresa Stephens Dr. Mary E. Gerritsen Mr.* and Mrs. Barry M. Butcher Tom and Judy Sproule Greenstein Family* Mr. and Mrs. James L. Clunan Mrs. Clare Stone Dr. and Mrs. Anthony M. Guarino Susan E. Cochran and David S. Larkin Richard TenEyck and Marie Taylor Dr.* and Mrs. Dan R. Halm Dr. and Mrs. Martin A. Connaughton Ryan J. Toso Lee M. Jampol, M.D.* and Ms. Erma Tranter Dr. and Mrs. Richard Crawford Ms. Jean Travers Mr. Lawrence C. Johnston Ms. Trillium Cserr* Dr. Paul C. Tsang* S. Joel Karp Mr.† and Mrs. David Cutler Dustin and Andrea Updike Susan Lerner and Steven Katona Dr. and Mrs. Garry Cutting Barry and Jane Young James* and Charlotte* Keller Dr. Muriel T. Davisson Maggie and Jack Kelley Anne Reed Dean† Christina* and Harold Kurland Beth Rendeiro and Steven DePaul Clive J. Lawrence Ms. Nina Derby* Ms. Susan G. Letcher* Mr. Alan A. Dolnick Irwin List Mr. Chuck Donnelly William H. and Karen V. Lyons Mr. and Mrs. John F. Doyle

7 | 2019 REPORT FROM THE PRESIDENT OUR DONORS

MDI BIOLOGICAL LABORATORY PARTNERS Patricia H. Hand Outstanding Faculty Award Mr. L. Gordon Hamersley, Jr. MDI Biological Laboratory gratefully acknowledges the Roy A. McMorran Mrs. L. Gordon Hamersley, Jr. generous support we receive from our business partners and employers that match employee contributions. Morris Scientific Discovery Fund David Karnofsky Cotswold Foundation Trust, Dr.* and Mrs. Jerry Wacks Business Partners Mr. and Mrs. I. Wistar Morris III Archeron Scientific, Inc. William B. Kinter Christie’s Americas Orkand Lectureship in Neuroscience and Cell Signaling Anonymous The Company of Biologists Limited Drs. Jean M. and Joseph W. Sanger Allyn* and Karen Seymour Cystic Fibrosis Foundation The Gerontological Society of America William Procter Scientific Innovation Fund Mr. John S. Letcher, Jr. Gilead Sciences, Inc. Anonymous Ms. Susan G. Letcher* The Glenn Foundation for Medical Research Hanscom’s Motel and Cottages Salsbury Cove Research Fund Thomas H. Maren, M.D. Harold MacQuinn, Inc. Maine Community Foundation Suzanne and Albert Frederick InSphero Inc. James A. Rawls, M.D.* Intercept Pharmaceuticals, Inc. Dr. Patricio Silva Research Fund Life Biosciences, Inc. Ms. Kate Spokes Dr. Eli K. Marshall Miele Ms. Berry Marshall Hoak Nikon Instruments, Inc. Josephine A. Sollano Fellowship Novartis Josephine A. Sollano, Dr.PH. Dr. and Mrs. Herbert Neal Skretting North America Peggy Crowell Walklet and Family Tecniplast USA, Inc. David W. Towle Fellowship Fund William D. and Marilyn G. Wilson Town of Bar Harbor Dr. Betty M. Massie Robert and Joyce Preston Dr. Hugh Clive Palfrey* Matching Gift Companies And Foundations John and Jean Cameron FM Global Foundation GIFTS RECEIVED IN MEMORY GlaxoSmithKline OF THE FOLLOWING INDIVIDUALS Edward Palincsar, Ph.D. Jefferies LLC Donor names are italicized Anonymous Pfizer Foundation Matching Gifts Program Wellington Management Company, LLP Dr. James B. Allison David P. Rall, Ph.D. Dr. Marshall Smith and Mrs. Teresa Stephens Dr. and Mrs. Anthony M. Guarino SPECIAL FUNDS Donor names are italicized Ned Ballatori, Ph.D. Dr. Raymond Rappaport Jeanne L. DelSignore, M.D. Drs. Robert* and Sondra Howe Blum Halsey Scholars Fund Dr.* and Mrs. Thomas W. Simmons Drs. Jean M. and Joseph W. Sanger Yoakum Fund of the Maine Community Foundation Mrs. Lisa Bertrand Eugene Debs Robin John W. Boylan Fellowship Harold Bertrand Dr.* and Mrs. Jerry Wacks Anne W. Boylan* and John A. Cadwallader Drs. Earl O. Butcher and Elmer D. Butcher Bernice and Leonard Silk The Bradley Stanley Fellowship Mr.* and Mrs. Barry M. Butcher Erica Kirsners Silk and Adam Silk Jane* and Abass Alavi Ashley Fister Cole Margaret Sheldon Community Environmental Health Laboratory Brian and Sarah Cole Lura* and Bill Clark Maine Community Foundation Alex C. Walker Foundation Helen Cserr Rosemarie Sollano Ken Mackie* Josephine A. Sollano, Dr.PH. Eelgrass Restoration Fund Long Cove Foundation, Inc., Dr. Margot E. Doyle Janet H. Spokes Kristin and Michael Sant Ray* and Katharine Stanford Ms. Kate Spokes The Nature Conservancy, Maine Chapter Franklin H. Epstein, M.D. Steven R. Strong, M.D. Roy P. Forster Fellowship Anatole and Fani Besarab Mrs. Sohny Kang Strong Drs. Jean M. and Joseph W. Sanger George P. Bayliss, M.D. Dr. Thomas L. Watt Sherrie S. Epstein GIFTS RECEIVED IN HONOR OF THE FOLLOWING INDIVIDUALS The Hamilton Pond Fund Michael Field, M.D. Donor names are italicized Dr. Dianna and Mr. Benjamin R. Emory Irwin List Hanscom’s Motel and Cottages Dr. Peter J. Allen Harold MacQuinn, Inc. Dr. Leon Goldstein Phoebe and Jim Boyer Dr. Lewis Kinter* and Ms. Terry Timberlake-Kinter Barbra Goldstein Maine Community Foundation Frank and Carmen Brewer Town of Bar Harbor Ms. Roxanne Greenstein Loretta M. Shirey Anne W. Boylan* and John A. Cadwallader Greenstein Family

8 | 2019 REPORT FROM THE PRESIDENT OUR DONORS

* Alumni of MDI Biological Jane E. Disney, Ph.D. Laboratory’s research Betsey Holtzmann training programs † Deceased David H. Evans, Ph.D. Don and Rena McCrimmon

Dr. John N. Forrest, Jr. Peter Aronson and Marie Landry

Dr. Hermann Haller Dr.* and Mrs. Mordecai P. Blaustein

Mr. and Mrs. Clayton Jones Leila Lituchy

Mr. Joel Karp Danielle and Mathew Stordy

Ms. Carol Kim Elizabeth Allan and Brian Rahill

Kelly M. LaRue, Ph.D.* Mr. and Mrs. Edward LaRue

Gary E. Lyons and Jayne Squirrell William H. and Karen V. Lyons

Mrs. Barbara Rappaport Nancy Abuhaydar

Ms. Clare Stone Robert Whitman and Jeffrey Munger

JOHN S. KINGLSEY SOCIETY Members of the John S. Kingsley Society have graciously supported the MDI Biological Laboratory by making a legacy gift.

Mrs. Virginia Agar Dr. Edward J. Benz, Jr. and Dr. Margaret A. Vettese Dr. and Mrs. James L. Boyer Ms. Mary M. Brandes* Mrs. Sarah L. Clark Dr. Ben Crocker Ms. Ruth Cserr and Dr. Robert Savell Dr. and Mrs. John N. Forrest, Jr. Gary and Giva Frashier Drs. Arnold* and Nora Goldschlager Dr. Lowell Hokin Dr. and Mrs. Frederick Homburger† Drs. Elinor and Victor Kelmenson Mr. and Mrs. Lennart Lindegren Don and Heather Parker Drs. Pam and Stephen Ross Mr. and Mrs. William D. Wilson

9 | 2019 REPORT FROM THE PRESIDENT OUR FELLOWSHIP RECIPIENTS

2018 FACULTY FELLOWSHIP Maine INBRE (IDeA Network of Biomedical Ryan Tebo RECIPIENTS Research Excellence), National Institute of University of Maine Presque Isle General Medical Sciences Mentor: Jarod Rollins, Ph.D. Maria Armillei Blum Halsey Scholars Fund MDI Biological Laboratory Hugo de Jonge, Ph.D. Colby College Benjamin Tero Erasmus University Medical Center, The Netherlands Mentor: Kristy Townsend, Ph.D. University of Maine Orono University of Maine Honors College Joseph Shaw, Ph.D. Mentor: Melody Neely, Ph.D. Alan Baez Dartmouth College University of Maine Orono University of Maine Honors College Victoria Vargas James L. Boyer Fellowship Mentor: Julie Gosse, Ph.D. Robert L. Morris, Ph.D. University of Maine Orono Franklin Pierce University Wheaton College Mentors: Andrew Perron, Ph.D. and Casey MacVane, Ph.D. Samuel Brill-Weil Maine Medical Center Research Institute Bowdoin College David H. Evans Visiting Faculty Fellowship Andrea Tilden, Ph.D. Mentor: Hadley Horch, Ph.D. Maine Scholars Program Adam Christianson Colby College Bowdoin College Mount Desert Island High School Ian Davis John N. Forrest, Jr. Fellowship Mentor: Andrea Tilden, Ph.D. and Joel Graber, Ph.D. Andrea Tilden, Ph.D. University of New Hampshire MDI Biological Laboratory Colby College Mentor: Joshua Martin, Ph.D. Colby College Mount Sinai School of Medicine Diamond Mensah Roy P. Forster Fellowship Andrea Tilden, Ph.D. Sharon Jordan The High School for Math, Science & Engineering Southern Maine Community College Colby College Mentor: Hermann Haller, M.D. Mentor: Lucy Liaw, Ph.D. MDI Biological Laboratory Hugo de Jonge, Ph.D. Maine Medical Center Research Institute James Slater Murphy, M.D. Fellowship Fund Erasmus University Medical Center, The Netherlands Jagjit Lally Kathryn Boit Bates College Granby Memorial High School Maine INBRE (IDeA Network of Biomedical Research Excellence), National Institute of General Mentor: Tariq Ahmad, Ph.D. Mentor: Robert Preston, Ph.D. Medical Sciences Colby College MDI Biological Laboratory Andrea Tilden, Ph.D. Eli Michaud Merline Feero Colby College University of Maine Farmington Waterville Senior High School Salsbury Cove Research Fund Mentor: Melody Neely, Ph.D. Mentor: Robert Preston, Ph.D. Robert Preston, Ph.D. University of Maine Orono MDI Biological Laboratory Illinois State University Audrey Muscato Jade Lee Joseph Shaw, Ph.D. Bowdoin College McGill University Dartmouth College Mentor: Patsy Dickinson, Ph.D. Mentor: Jane Disney, Ph.D. Bowdoin College MDI Biological Laboratory

Romario Romain Emily Xu 2018 STUDENT FELLOWSHIP University of Maine Fort Kent College of William and Mary RECIPIENTS Mentor: Samuel Beck, Ph.D. Mentor: Dustin Updike, Ph.D. MDI Biological Laboratory MDI Biological Laboratory Anonymous Donors Isabelle Russell Lauren Masse Chase McGee Southern Maine Community College University of Maine at Augusta Mount Desert Island High School Mentor: Aric Rogers, Ph.D. Mentor: Aric Rogers, Ph.D. Mentor: Joel Graber, Ph.D. MDI Biological Laboratory MDI Biological Laboratory MDI Biological Laboratory Bailey Shevenell Natalie VanderNoot Nicholas Pederson University of Maine Farmington Lebanon High School Western Washington University Mentor: Elwina Bolcun-Filas, Ph.D. Mentors: Andrea Tilden, Ph.D. and Joel Graber, Ph.D. Mentor: Jarod Rollins, Ph.D. The Jackson Laboratory MDI Biological Laboratory MDI Biological Laboratory Isabella Stone David Venator Alejandro Schmieder Bates College Concord High School Cornell University Mentor: Hermann Haller, M.D. Mentor: Joel Graber, Ph.D. Mentor: Andrea Tilden, Ph.D. MDI Biological Laboratory MDI Biological Laboratory MDI Biological Laboratory Nathan Yeung The Academy for Science and Design Mentor: Andrea Tilden, Ph.D. MDI Biological Laboratory 10 | 2019 REPORT FROM THE PRESIDENT OUR ADVISORS, FACULTY AND STAFF

2018 ADVISORS, Dustin L. Updike, Ph.D. STAFF FACULTY AND STAFF Assistant Professor Judith A. Alexander Education Events Coordinator BOARD OF SCIENTIFIC COUNSELORS Voot P. Yin, Ph.D. Dr. Barbara S. Beltz, Ph.D. Associate Professor Stephanie E. Anderson Wellesley College Scientific Resource Specialist VISITING FACULTY Dennis Brown, Ph.D. James Boyer, M.D. Caitlin Bailey Mass. General Hospital and Harvard Medical School Yale University School of Medicine Systems Developer, Webmaster

Donal Thomas Manahan, Ph.D. Hugo de Jonge, Ph.D. Hannah E. Barnhart University of Southern California Erasmus University Medical Center, The Netherlands Animal Care Technician

Andres Villu Maricq, M.D., Ph.D. Gert Fricker, Ph.D. Margaret T. Bertocci University of Utah University of Heidelberg, Germany Animal Care Technician

Eric N. Olson, Ph.D. Robert Preston, Ph.D. Rose Besen-McNally* University of Texas Southwestern Medical Center Illinois State University Research Technician

Thomas Rando, M.D., Ph.D. Mario Schiffer, M.D. Laura L. Beverly-Staggs Stanford University School of Medicine Hannover Medical School, Germany Research Assistant

Nadia A. Rosenthal, Ph.D. Joseph Shaw, Ph.D. Jessie K. Bolduc The Jackson Laboratory Indiana University Research Assistant

Alejandro Sánchez Alvarado, Ph.D. Patricio Silva, M.D. Jacqueline C. Bolt Stowers Institute for Medical Research and Howard Temple University Senior Accountant Hughes Medical Institute Bruce Stanton, Ph.D. Patricia A. Boyce E. Brad Thompson, M.D. Geisel School of Medicine at Dartmouth Accounting Assistant University of Texas Medical Branch and Univ. of Houston Andrea Tilden, Ph.D. Kristen L. Bradbury FACULTY Colby College Food Services Manager Samuel Beck, Ph.D. Assistant Professor SENIOR STAFF Rebeka M. Bullard Jerilyn M. Bowers Research Assistant James A. Coffman, Ph.D. Director of Development and Public Affairs Associate Professor; Director, Maine INBRE Bryan J. Butler (IDeA Network of Biomedical Research Excellence) Jane E. Disney, Ph.D. Physical Plant Staff Director of Education and Senior Staff Scientist Jane E. Disney, Ph.D. Michelle L. Chaloult Senior Staff Scientist; Director of Education; Hermann Haller, M.D. Dining Hall Cook Director, Community Environmental Health Laboratory President Heather L. Church James Godwin, Ph.D. Patricia H. Hand, Ph.D. Custodial Coordinator Assistant Professor Senior Advisor to the President Ari S. Dehn* Joel H. Graber, Ph.D. Mark A. Hanscome Research Assistant Senior Staff Scientist; Director, Computational Biology Director of Facilities and Bioinformatics Core Anne E. Farrell Claudine D. Lurvey Community Environmental Health Laboratory Manager Herman Haller, M.D. Director of Finance President and Professor MaryLynn F. FitzSimons, Ph.D. Stefanie N. Matteson Graduate Research Assistant Vicki P. Losick, Ph.D. Director of Communications Assistant Professor Jeremy H. Fuqua* Roy A. McMorran Research Technician Sandra Rieger, Ph.D. Director of Information Technology Assistant Professor Benjamin M. Garthoff* Patricia A. Pcolar Research Assistant Aric N. Rogers, Ph.D. Director of Human Resources Assistant Professor Judith C. Sproule Bonnie L. Gilfillan Director of Strategic Initiatives Special Events/Donor Stewardship Coordinator Kevin Strange, Ph.D. Professor; Director, Davis Center of Biomedical Research Kayla J. Gjelsvik Excellence in Regeneration and Aging Biology Graduate Research Assistant

11 | 2019 REPORT FROM THE PRESIDENT OUR ADVISORS, FACULTY AND STAFF

ABOUT US We are discovering new approaches to Navdeep Gogna, Ph.D. Amy Richards regenerative medicine by developing drugs Postdoctoral Research Fellow Executive Assistant that slow age-related degenerative diseases and activate our natural ability Gary L. Gorczyca Kristine Reaman to heal. Our unique approach has identified Physical Plant Staff Program Administrator potential therapies that could revolutionize the treatment of heart disease, muscular Janelle E. Grendler* Adriana M. Rodriguez, Ph.D. dystrophy and more. Through the Maine Research Assistant Postdoctoral Research Fellow Center for Biomedical Innovation we are preparing students for 21st century careers Ellen I. Hartig Romario Romain* and equipping entrepreneurs with the Research Assistant Resident Assistant knowledge and skills to turn discoveries into applications that improve human Jordan N. Horrocks Thomas S. Rush health and well-being. Research Assistant Physical Plant Staff BOARD OF TRUSTEES Lucie N. Hutchins Jilliane L. Sawyer Bioinformatics Software Engineer Jr. Accountant and Payroll Specialist Edward J. Benz, Jr., M.D., Acting Chairman Dana Farber Cancer Institute

Phasathon Itthipalakorn Patricia A. Schroder, Ph.D. Peter J. Allen, M.D., Vice Chairman Duke University Research Assistant Research Assistant Thomas A. Boyd, Ph.D., Treasurer Anthology BioDevelopment LLC Robert D. Landis Catherine S. Sharp* Custodian Research Assistant Alan W. Kornberg, Esq., Secretary Paul, Weiss, Rifkind, Wharton & Garrison LLP

Junyeong Lee, Ph.D. Jocelyn C. Sharp* Hermann Haller, M.D., President, ex officio Postdoctoral Research Fellow Development and Communications Assistant MDI Biological Laboratory

Phoebe C. Boyer Nathaniel J. Maki Juyoung K. Shim, Ph.D. The Children’s Aid Society Bioinformatics Training Specialist Postdoctoral Research Fellow Terence C. Boylan

Isaiah N. Mansour* Christina A. Siddons Maximiliaan J. Brenninkmeyer

Research Assistant Research Assistant Ned T. Cloonan Ned Cloonan Associates Karlee R. Markovich Ashley M. Smith Ruth Cserr Scientific Resources Coordinator Research Assistant Joanne R. Firstenberg Compass Michele D. Marks Christine M. Smith* Philanthropy Officer Assistant Director of Education John A. Hays Christie’s

Elisabeth A. Marnik, Ph.D. Santina M. Snow* Frank L. Hohmann III

Post Doctoral Researcher Research Assistant Lewis B. Kinter, Ph.D. Green Lawn Scientific Consulting LLC James L. Miller Amy L. Somes Research Assistant COBRE Program Administrator Anne H. Lehmann Alan B. Miller, Esq.

Amy R. Morley Kenneth M. Stecher I. Wistar Morris III Development Data Analyst Dining Hall Cook Penn Trust

Margaret A. Myers, M.D. Rebecca E. Morrison Ashley R. Taylor Research Laboratory Manager Community Environmental Health Laboratory Christopher P. Sighinolfi. Jefferies Data Specialist Kristoph S. Naggert* Josephine A. Sollano, M.P.H., Dr.P.H. Bioinformatics Programmer/Analyst Andrea R. Tilden, Ph.D. Bruce A. Stanton, Ph.D. Geisel School of Medicine at Dartmouth Residential Life Coordinator Mark F. Nicknair Clare Stone

Assistant Director of Facilities Kassie L. Warren Daphne W. Trotter, Esq. Dining Hall Cook McDermott Will & Emery LLP Austin T. Orecchio Scientific Resource Specialist Amber M. Wolf* Published by the Office Education Projects and Training Lab Coordinator of Communications Amy D. Pelletier Editor + Writer Stefanie Matteson Sponsored Programs Manager Toshiki Yamada, Ph.D. Design Cushman Creative Research Assistant Professor Frances C. Phalan Photography Linda O’Kresik, Rogier van Research Assistant and Research Anne Yu Bakel, Lief Oxburgh Laboratory at the Maine Medical Center Research Institute, Amber and Safety Compliance Officer Scientific Resource Specialist Wolf of the MDI Biological Laboratory

12 | 2019 REPORT FROM THE PRESIDENT PO Box 35 Salisbury Cove, ME 04672 207.288.3605 | mdibl.org

TO OUR VALUED PARTNERS,

Together with you, our valued OUR MISSION partners, we are explorers The MDI Biological Laboratory is an independent, nonprofit on the most important frontier biomedical research institution st dedicated to improving human in the 21 century science: health and well-being through the unchartered territory that basic research, education and ventures that transform lies deep within the cell. discoveries into cures. We are enormously grateful for your continued support on this path of discovery.

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13 | 2019 REPORT FROM THE PRESIDENT