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Particle Characterization in the Cosmetics Industry

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Particle Characterization in the Cosmetics Industry Particle Characterization in the Cosmetics Industry Mark Bumiller [email protected] © 2010 HORIBA, Ltd. All rights reserved. Particles in Cosmetics Any product containing a powder Pigments, talc, mica Emulsions (creams, lotions) Liposomes; simple, complex Types of cosmetics containing particles (emulsion droplets) © 2009 HORIBA, Ltd. All rights reserved. Original Foundation: Pan-Cake Foundation and powder in one Base was talc (particle), not oil or wax Applied with wet sponge Patent in 1937 By 1940 1 in 3 N American women owned & wore Pan- Cake © 2009 HORIBA, Ltd. All rights reserved. Create our Own Product Base They’re all zTalc, rice powder particles! Pigment Can measure zIron oxide size of all Filler using one system: zClay LA-950 Glitter zMica SPF zTiO2 © 2009 HORIBA, Ltd. All rights reserved. Measuring Powders as Powders •Direct flow of powder to cell •0 to 4 bar •Report P used •Feedback to control powder flow LA-950 Add powder to vibrating tray, flows through cell where measurement made. Quick, easy, no glassware to clean. © 2009 HORIBA, Ltd. All rights reserved. Base: Rice Powder © 2009 HORIBA, Ltd. All rights reserved. Iron Oxide – 170 Shade Use ultrasound? LA-950 wet accessories Disperse powder into a liquid Can measure down to 30 nm © 2009 HORIBA, Ltd. All rights reserved. Gold Glitter Powder Measure wet + dry, choose preferred Verify correct P for dry powder feeder Wet Dry © 2009 HORIBA, Ltd. All rights reserved. Gold Glitter Image Analysis Optics Powder Disperser © 2009 HORIBA, Ltd. All rights reserved. Shape Parameters ISO 9276-6:2008 :Representation of results of particle size analysis – Part 6: Descriptive and quantitative representation of particle shape and morphology Meso-shape descriptors How round? Circularity: C = 4 π A P2 Aspect ratio? AR = xFmin/xFmax not for very elongated Convexity = Pc/P Pc = convex hull perimeter © 2009 HORIBA, Ltd. All rights reserved. Mica © 2009 HORIBA, Ltd. All rights reserved. Kaolin Clay Note: small % below 100 nm, making this a “nanoparticle. Safety concerns? © 2009 HORIBA, Ltd. All rights reserved. Sunscreen: TiO2 Powder dispersed in water using surfactant and ultrasound. Note: 14.5% < 100nm Safety concerns? © 2009 HORIBA, Ltd. All rights reserved. Sunscreen w/ZnO Note: %< 100nm depends on sample treatment (ultrasound) © 2009 HORIBA, Ltd. All rights reserved. Sunscreen: ZnO © 2009 HORIBA, Ltd. All rights reserved. Nanoparticle Safety: Cosmetics “Preliminary scientific research has shown that many types of nanoparticles can be toxic to human tissue and cell cultures…” Suggests banning all cosmetics with particles <100nm Many sunscreens contain ZnO or TiO2 particles <100 nm © 2009 HORIBA, Ltd. All rights reserved. Nanoparticle Safety NGO Friends of the Earth issue report requesting ban on all skin care products w/particles <100nm Claim: some nano-articles are dangerous, so ban all Industry claims some nano-particles are safe, so don’t worry FDA says we only believe data in peer reviewed journals, but form task force to investigate In 2012 Cosmetics manufactures must notify European Commission of any “nanoscale materials” in products © 2009 HORIBA, Ltd. All rights reserved. Nanoparticle or Not? SSA = 6/ρD ultrasound 50 nm D from SEM ~50 nm Used ultrasound to disperse D from SSA ~60-70 nm to primary particles or use D from DLS ~250 nm weak acid to break bonds (light scattering due to D from DLS ~50 nm Brownian motion) So: is this a nanoparticle? © 2009 HORIBA, Ltd. All rights reserved. Acoustics: ZnO Study POWDER Name, Median size, Cum % of nano- Manufacturer microns particles <100 nm Zinc oxide, 99.5+% by Acros 0.273±0.01 11.0±1.4 Organics Zinc oxide, reagent ACS by 0.430±0.02 7.0±0.5 Acros Organics Z50-500 USP powder 0.561±0.017 2.7±0.39 packaged by Fisher Scientific Z52-500 USP powder 0.660±0.037 1.9±0.4 packaged by Fisher Scientific Base S80249 by Fisher Scientific 0.398 ± 0.001 6.1±0.2 Zinc oxide ACS reagent grade 0.349±0.017 8.2±2.1 by MO Biomedicals, LLC Zinc oxide Polystormor by 0.223±0.009 19.6±1.8 Mallinckrodt Chemicals Dopant Zinc oxide Nanopowder by 0.631±0.1 4.7±2.5 American Elements © 2009 HORIBA, Ltd. All rights reserved. Acoustics: ZnO Study Zinc oxide, reagent ACS by Acros Organics Zinc oxide, 99.5+% Acros Organics Z50-500 USP Z52-500 USP 1.2 S80249 by Fisher Scientific Zinc oxide 99.99% by Alfa Aesar Zinc oxide ACS MO Biomedicals, LLC PolystormorTM by Mallinckrodt Chemicals 1.0 Nanopowder America Elements s i 0.8 s a b t h g i 0.6 e w , D S 0.4 P 0.2 0.0 10-2 10-1 100 101 Diameter [um] © 2009 HORIBA, Ltd. All rights reserved. © reserved. rights Ltd.All HORIBA, 2009 Attenuation [dB/cm/MHz] 0 1 2 3 4 5 6 7 8 10 0 Frequency [MHz] zinc oxideAinsolvent Acoustics: ZnOStudy 10 1 zinc oxideBinwater 10 2 PSD, weight basis 100 1.6 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 20 40 60 80 0 10 -2 zinc oxideA nano-particles range 10 Diameter [um] -1 10 0 zinc oxideB 10 1 Acoustics: ZnO Study Percentage of nano particles 7 in Z52-500 sample after incremental additions of the 6 Mallinckrodt Chemicals sample. The X-axis is a percentage d e r 5 u s calculated from the known a e m , amount of the added Mallinckrodt s e l c i 4 t r sample, assuming that it contains a p - o 20% on nano-particles, according n a n 3 % to the Table 1. The Y-axis is a percentage calculated from the 2 attenuation spectra, which is measured for the mixture. 1 1 2 3 4 5 6 % nano-particles, estimated © 2009 HORIBA, Ltd. All rights reserved. DT-1201 Hardware sample © 2009 HORIBA, Ltd. All rights reserved. Electroacoustics – Zeta Potential Piezo crystal Electrodes A Zeta Potential Probe ColloidVibrationCurrent ρρpm− CVI= Cϕμd∇ P ρm Dynamic..Mobility ε mεoς (ρ p − ρs )ρm Ks μd = η (ρ p − ρm )ρs Km © 2009 HORIBA, Ltd. All rights reserved. Zeta Potential If surface has + charge, then - ions attracted to surface + ions attracted to – ions, builds electric double layer Slipping plane: distance from particle surface where ions move with particle ZP = potential (mV) at slipping plane © 2009 HORIBA, Ltd. All rights reserved. Stability Want stable dispersion good Either suspensions or emulsions Suspensions bad sediment & flocculate Emulsions phase separate, creaming good or coalescence bad © 2009 HORIBA, Ltd. All rights reserved. Stabilization Steric stabilization: coat surface with polymers Particles can’t touch so they don’t interact Electrostatic stabilization: alter surface chemistry to put charge on particle surface Repel like magnets © 2009 HORIBA, Ltd. All rights reserved. pH Titration of Rutile 7%vl & Alumina 4%vl 85 nm 300 nm PSD unstable @ IEP aggregates form © 2009 HORIBA, Ltd. All rights reserved. Skin Cream Emulsion w/SPF 15 © 2009 HORIBA, Ltd. All rights reserved. Emulsion Stability Greater zeta potential Add surfactant to Stabilize emulsion Test zeta potential Vs. surfactant conc. © 2009 HORIBA, Ltd. All rights reserved. Emulsions Creams: semi-solid emulsions, mixtures of oil & water Ointment : viscous semisolid preparation used topically zVehicle of an ointment is known as ointment base zHydrocarbon bases e.g. hard paraffin, soft paraffin zAbsorption bases e.g. wool fat, beeswax zWater soluble bases e.g. macrogols 200, 300, 400 zEmulsifying bases e.g. emulsifying wax, cetrimide zVegetable oils e.g. olive oil, arachis oil, coconut oil © 2009 HORIBA, Ltd. All rights reserved. Emulsions Liniment, (or embrocation) is a medicated topical preparation for application to the skin. Preparations of this type are also called balm. z Liniments are of a similar viscosity to lotions (being significantly less viscous than an ointment or cream) but unlike a lotion a liniment is applied with friction; always rubbed in. z Liniments are typically sold to relieve pain and stiffness Paste: substance that behaves as a solid until a sufficiently large load or stress is applied, at which point it flows like a fluid. © 2009 HORIBA, Ltd. All rights reserved. Cosmetic Emulsion Patent Microemulsions are Transparent & thermodynamically stable, <150 nm Collected with HORIBA LB-500 LB-550 © 2009 HORIBA, Ltd. All rights reserved. Liposomes © 2009 HORIBA, Ltd. All rights reserved. Liposome Delivery Active ingredient Penetrates into skin Liposome approaches Liposome fuses with Liposome dissolves & skin barrier layer skin barrier layer releases actives (retinol?) © 2009 HORIBA, Ltd. All rights reserved. Liposomes by DLS Liposome size after 5 passes through 100 mm membrane, mean size ~ 250 nm www.horiba.com/us/en/scientific/products/particle-characterization/ Liposome size after 20 passes through 100 mm membrane, mean size ~ 150 nm © 2009 HORIBA, Ltd. All rights reserved. Retinol Formulation - Delivery “Retinal contained in the core space of the vesicle which has a mean diameter of 10~50nm”… © 2009 HORIBA, Ltd. All rights reserved. Summary Many cosmetic products either powder (particle) based, or contain powders Wide range measured by laser diffraction (LA-950) Image analysis provides additional shape information Acoustics measures size & zeta potential with no dilution DLS for sub-micron size + dilute zeta potential © 2009 HORIBA, Ltd. All rights reserved. For More Details Visit horiba.com Application Notes: z AN152 Measuring Emulsions using Acoustics z AN161 Particle Size Analysis of Cosmetics z AN171 Measuring Nanoparticles using Acoustics z AN174 Measuring Liposomes using DLS Webinars: z State of the Art Laser Diffraction Performance z The DT Series Acoustic Spectrometers z Size and Stability for Biotech and Nanotech © 2009 HORIBA, Ltd. All rights reserved..
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