ii Contents of Volume 74, 2010

CONTENTS OF VOLUME 74, 2010

Message From the Editor-in-Chief

1. Circulation Journal – A Cloud Over the Hill – Hiroaki Shimokawa ········· 1 2. Editorial Statistics and Best Reviewers Awards for 2009 Hiroaki Shimokawa ········· 211 3. Circulation Journal Awards of the Year 2009 Hiroaki Shimokawa ········· 387 4. New Editorial Team of Circulation Journal Hiroaki Shimokawa ········· 1263 5. Message From the Editor-in-Chief Hiroaki Shimokawa ········· 1499 6. Message From the Editor-in-Chief Hiroaki Shimokawa ········· 1769

Reviews

1. Tissue Factor and Cardiovascular Disease – Quo Vadis? – Alexander Breitenstein, Felix C. Tanner, Thomas F. Lüscher ········· 3 2. Mechanisms of Myocardial Regeneration Toru Hosoda, Jan Kajstura, Annarosa Leri, Piero Anversa ········· 13 3. Three-Dimensional Electroanatomic Mapping Systems in Catheter Ablation of Atrial Fibrillation Li-Wei Lo, Shih-Ann Chen ········· 18 4. Non-Invasive Vascular Function Tests – Their Pathophysiological Background and Clinical Application – Hirofumi Tomiyama, Akira Yamashina ········· 24 5. Non-Invasive Assessment and Clinical Strategy of Stable Coronary Artery Disease by Magnetic Resonance Imaging, Multislice Computed Tomography and Myocardial Perfusion SPECT Naoya Matsumoto, Ken Nagao, Atsushi Hirayama, Yuichi Sato ········· 34 6. Inflammation in Atherosclerosis – Transition From Theory to Practice – Peter Libby, Yoshihisa Okamoto, Viviane Z. Rocha, Eduardo Folco ········· 213 7. The Initiation of the Heart Beat Peng-Sheng Chen, Boyoung Joung, Tetsuji Shinohara, Mithilesh Das, Zhenhui Chen, Shien-Fong Lin ········· 221 8. Coordination of Vasomotor Responses by the Endothelium Kim A. Dora ········· 226 9. Characteristics of Chronic Rejection in Heart Transplantation – Important Elements of Pathogenesis and Future Treatments – Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai ········· 233 10. Coronary Angioscopic Evaluation for Serial Changes of Luminal Appearance After Pharmacological and Catheter Inter- ventions Masamichi Takano, Kyoichi Mizuno ········· 240 11. Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction Xian-Liang Tang, D. Gregg Rokosh, Yiru Guo, Roberto Bolli ········· 390 12. Angiotensin-Converting Enzyme 2 (ACE2) in Disease Pathogenesis Yumiko Imai, Keiji Kuba, Takayo Ohto-Nakanishi, Josef M. Penninger ········· 405 13. Acute Coronary Syndrome – Insight From Angioscopy – Yasunori Ueda, Nobuyuki Ogasawara, Koushi Matsuo, Shinichi Hirotani, Kazunori Kashiwase, Akio Hirata, Mayu Nishio, Takayoshi Nemoto, Mitsuru Wada, Yuki Masumura, Toshikazu Kashiyama, Shouzou Konishi, Hiroyuki Nakanishi, Yusuke Kobayashi, Yasuhiro Akazawa, Kazuhisa Kodama ········· 411 14. Role of the SDF-1/CXCR4 System in Myocardial Infarction Masafumi Takahashi ········· 418 15. Basic Principles of Platelet Biology and Clinical Implications Dominick J. Angiolillo, Masafumi Ueno, Shinya Goto ········· 597 16. Potassium Channels and Neurovascular Coupling Kathryn M. Dunn, Mark T. Nelson ········· 608 17. Waon Therapy for Cardiovascular Disease – Innovative Therapy for the 21st Century – Masaaki Miyata, Chuwa Tei ········· 617

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 iii

18. The Future of Pharmacological Therapy for Heart Failure Yusuke Sata, Henry Krum ········· 809 19. Pleiotropic Effects of Statins – Basic Research and Clinical Perspectives – Qian Zhou, James K. Liao ········· 818 20. Oxidative Stress and Central Cardiovascular Regulation – Pathogenesis of Hypertension and Therapeutic Aspects – Yoshitaka Hirooka, Yoji Sagara, Takuya Kishi, Kenji Sunagawa ········· 827 21. Prostacyclin in Vascular Diseases – Recent Insights and Future Perspectives – Jun-ichi Kawabe, Fumitaka Ushikubi, Naoyuki Hasebe ········· 836 22. Current State of Surgical Myocardial Revascularization Frank W. Sellke, Louis M. Chu, William E. Cohn ········· 1031 23. What We Have Learned From the Family of Multicenter Automatic Defibrillator Implantation Trials Arthur J. Moss ········· 1038 24. Stromal Cell Biology – A Way to Understand the Evolution of Cardiovascular Diseases – Toshihiro Tsuruda, Takuroh Imamura, Kinta Hatakeyama, Yujiro Asada, Kazuo Kitamura ········· 1042 25. Electrophysiological Characteristics of Atrial Tachycardia After Pulmonary Vein Isolation of Atrial Fibrillation Kazuhiro Satomi ········· 1051 26. Novel Heart Failure Therapy Targeting Transcriptional Pathway in Cardiomyocytes by a Natural Compound, Curcumin Tatsuya Morimoto, Yoichi Sunagawa, Masatoshi Fujita, Koji Hasegawa ········· 1059 27. Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure Vera Regitz-Zagrosek, Sabine Oertelt-Prigione, Ute Seeland, Roland Hetzer ········· 1265 28. Heart Failure, Chronic Kidney Disease, and Biomarkers – An Integrated Viewpoint – Yoshitaka Iwanaga, Shunichi Miyazaki ········· 1274 29. Coronary Collateral Growth and Its Therapeutic Application to Coronary Artery Disease Masatoshi Fujita, Shigetake Sasayama ········· 1283 30. Mechanisms of Vein Graft Adaptation to the Arterial Circulation – Insights Into the Neointimal Algorithm and Man- agement Strategies – Akihito Muto, Lynn Model, Kenneth Ziegler, Sammy D.D. Eghbalieh, Alan Dardik ·········· 1501 31. Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis Hidehiko Hara, Robert S. Schwartz ········· 1513 32. Heparin Cofactor II Attenuates Vascular Remodeling in Humans and Mice Ken-ichi Aihara ········· 1518 33. ISAR – A Story of Trials With Impact on Practice – Stefanie Schulz, Julinda Mehilli, Albert Schömig, Adnan Kastrati ········· 1771 34. Cardiovascular Side-Effects of Modern Cancer Therapy Manabu Minami, Shigemi Matsumoto, Hisanori Horiuchi ········· 1779 35. Cardioprotection by Hormetic Responses to Aldehyde Motoaki Sano ········· 1787 36. Diet and Risk of Atrial Fibrillation – Epidemiologic and Clinical Evidence – Noelle N. Gronroos, Alvaro Alonso ········· 2029 37. Early Repolarization Syndrome – A New Electrical Disorder Associated With Sudden Cardiac Death – Shinsuke Miyazaki, Ashok J Shah, Michel Haïssaguerre ········· 2039 38. Macrophages, Oxysterols and Atherosclerosis Norihito Shibata, Christopher K. Glass ········· 2045 39. Cyclophilin A – Promising New Target in Cardiovascular Therapy – Kimio Satoh, Hiroaki Shimokawa, Bradford C. Berk ········· 2249 40. Aging and Arterial Stiffness Hae-Young Lee, Byung-Hee Oh ········· 2257 41. Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis Tomoyuki Yasuda, Tatsuro Ishida, Daniel J. Rader ········· 2263 42. Risk Stratification and Role of Implantable Defibrillators for Prevention of Sudden Death in Patients With Hypertrophic Cardiomyopathy Barry J. Maron ········· 2271 43. Heart Failure and the Lung Kirk Kee, Matthew T. Naughton ········· 2507 44. Cardiogenesis From Human Embryonic Stem Cells – Mechanisms and Applications – John L. Mignone, Kareen L. Kreutziger, Sharon Paige, Charles E. Murry ········· 2517 45. Role of Cellular Senescence in Lifestyle-Related Disease (2009 Sato Award) Tohru Minamino ········· 2527

Circulation Journal Vol.74, December 2010 iv Contents of Volume 74, 2010

Scientific Comments

The 2010 ESC Guidelines for AF 1. The 2010 Update of the ESC Guidelines for the Management of Atrial Fibrillation – What the Changes Will Mean for Clinicians – Sébastien Knecht, Stephen B. Wilton, Michel Haïssaguerre ········· 2534 2. The 2010 Update of the ESC Guidelines for the Management of Atrial Fibrillation – Beyond the Rate or Rhythm Strategy Debate – Jeffrey WH Fung, Cheuk-Man Yu ········· 2538 3. Antithrombotic Therapy – ESC Guidelines vs JCS Guidelines – Hiroshi Inoue ········· 2542

Editorials

1. Noncontact Mapping – Utility and Limitations – Yoshifusa Aizawa ········· 41 2. Japan Expects Decrements in Both the Incidence and Mortality of Acute Myocardial Infarction in the Modern Era – Likely or Just a Dream? – Masanori Asakura, Tetsuo Minamino, Masafumi Kitakaze ········· 43 3. Role of Endostatin in Cardiovascular Remodeling Koji Maemura ········· 45 4. Antenatal Glucocorticoid Therapy for Fetal Heart Development Masashi Arai ········· 47 5. Novel In Vivo Tool to Evaluate Autophagic Activity in the Heart Osamu Yamaguchi, Kinya Otsu ········· 49 6. Inflammation and Atrial Fibrillation Nobuhisa Hagiwara ········· 246 7. Green Tea Consumption and Prevention of Coronary Artery Disease Shinichi Kuriyama ········· 248 8. Is Right Ventricular Dysfunction in Obstructive Sleep Apnea a Potential Screening Tool? Masaaki Uematsu ········· 250 9. Can an Intravascular Imaging Modality Detect Really Vulnerable Plaque? Tadateru Takayama ········· 252 10. Cardiovascular Disease and Chronic Obstructive Pulmonary Disease Makoto Sata ········· 254 11. Towards a Tailored Use of Eluted Drugs for Percutaneous Coronary Interventions Marco Zimarino, Benedetta Ruggieri, Raffaele De Caterina ········· 424 12. Multidisciplinary Approach to Severe Coronary Artery Disease Masami Ochi ········· 426 13. Controversies on Obesity and CKD Sadayoshi Ito ········· 428 14. The Entire Coronary Arterial System Rather Than Just the Culprit Lesion Should be Evaluated in Patients With Acute Coronary Syndrome Shichiro Abe, Teruo Inoue, Isao Taguchi ········· 430 15. Role of Adiponectin in Cardiovascular Protection Mamoru Nanasato, Toyoaki Murohara ········· 432 16. PCI vs CABG in Complicated Diabetic Patients – Do We Need More Data to Change the Practical Guideline? – Kee-Sik Kim ········· 622 17. Long-Term Circulatory Support With a Left Ventricular Assist Device Therapy in Japan Satoshi Saito, Tomohiro Nishinaka, Kenji Yamazaki ········· 624 18. S100A8/A9 Complex – More Than Just a Biomarker of Cardiovascular Risk? – Kevin Croce ········· 626 19. Smoking Is a Disease and Smokers Are Patients Hisayoshi Fujiwara ········· 628 20. Clinical Significance of Mild Lipid-Lowering by Statins for Prevention of Cardiovascular Disease in Japanese High-Risk Patients Tetsuro Miyazaki, Hiroyuki Daida ········· 630 21. Significance of B-Type Natriuretic Peptide Measurement in Patients With Chronic Kidney Disease Yasunobu Hirata ········· 632 22. True Comparison of Different Stents in the Same Coronary Artery Yasunori Ueda ········· 844 23. Myocardial Transfection of Adeno-Hypoxia Inducible Factor-1α – A Novel Strategy to Potentiate Vasculogenesis in

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 

Ischemic Myocardium – Pavan Atluri ········· 846 24. Should β-Blockers Be Prescribed More Frequently to Japanese Patients With Coronary Artery Disease? Takuroh Imamura ········· 848 25. Is a “Pharmacogenomic Algorithm” Helpful for Adjusting the Initial Dose of Warfarin in Patients to Be Treated by War- farin Therapy? Shinya Goto ········· 850 26. True Autologous Approach in Cell Therapy – Using Your Own Serum for Cell Culture – Sung-Whan Kim, Young-Sup Yoon ········· 852 27. Adventitia as a Critical Player in the Functional Integrity of Arteries – Additional Support for Novel Clinical Procedures – Siu Ling Wong, Yu Huang ········· 854 28. Is Trance Esophageal Echocardiography Necessary Prior to Every Procedure of AF Ablation? – Balance of Risk vs Benefit – Kazuo Matsumoto ········· 1067 29. Acute Kidney Injury After Off-Pump Coronary Artery Bypass Grafting Teiji Oda ········· 1069 30. How Is Combination Therapy With ACEI and ARB Applied in Patients With Acute Myocardial Infarction? Kazuhiro Yamamoto ········· 1071 31. Regression-Resistant Plaque in Diabetic Patients Junya Ako, Shin-ichi Momomura ········· 1073 32. Does the Tongue Eloquently Address the Question of Cardiac Regeneration? Genzou Takemura ········· 1075 33. Platelet Reactivity With Prolonged Aspirin Treatment – Steady Going at 2 Years – Andrew L. Frelinger III ········· 1077 34. Antiplatelet Therapy in the Treatment of Takayasu Arteritis Masafumi Ueno ········· 1079 35. Tactics for the Reduction of Inappropriate Implantable Cardioverter Defibrillator Shocks Yuji Okuyama ········· 1290 36. Understanding the Essential Role of Monocytes in Atherosclerosis Shinzo Kimura, Takahisa Sawada ········· 1292 37. Is Low-Density Lipoprotein/High-Density Lipoprotein (LDL/HDL)-Cholesterol Ratio a More Important Predictor of Vulnerable Plaque in Coronary Artery Disease Than LDL- or HDL-Cholesterol? Kojiro Awano ········· 1294 38. Risk Assessment for Cardiovascular Disease – Microvascular Dysfunction – Yasushi Matsuzawa, Kiyoshi Hibi, Kazuo Kimura ········· 1296 39. Eicosapentaenoic Acid as the Gold Standard for Patients With Peripheral Artery Disease? – Subanalysis of the JELIS Trial – Dai Yamanouchi, Kimihiro Komori ········· 1298 40. Perivascular Adipose Tissue, a Janus-Faced Regulator of Vascular Function Toshihiro Ichiki ········· 1300 41. Magnetic Resonance Imaging for Evaluation of Left Atrial Lesions After Catheter Ablation of Atrial Fibrillation Osamu Igawa ········· 1524 42. We Should Not Hesitate to Use β-Blockers for Systolic Heart Failure With Concomitant Renal Dysfunction Naoki Matsuda ········· 1526 43. Glycoprotein IIb/IIIa Inhibitors to Facilitate Percutaneous Intervention in ST-Elevation Myocardial Infarction – The Sooner not Necessarily the Better – Luis A Guzman ········· 1528 44. Do We Facilitate Facilitated Percutaneous Coronary Intervention and Pre-Intervention Thrombolysis? Daisaku Nakatani, Hiroshi Sato ········· 1530 45. Application of Drug Eluting Stents to Clinical Practice in Japan – Are We Going in the Right Direction? – Jiro Aoki ········· 1532 46. Correction of the QT Interval in Children Naokata Sumitomo ········· 1534 47. Pharmacological Engineering of Endothelial Function and Vessel Response to Drug-Eluting Stents – Do-It-Yourself With Calcium-Channel and Angiotensin-Receptor Blockers? – Giuseppe Sangiorgi, Giuseppe Biondi-Zoccai ········· 1536 48. Systemic Acidosis in Acute Myocardial Ischemia – Cause or Result of Life-Threatening Ventricular Arrhythmia? – Shinichi Niwano, Taiki Tojo ········· 1794 49. Interventions for Drug-Eluting Stent Restenosis – To Cut, or not to Cut: Is that the Question? – Fernando Alfonso ········· 1796 50. Potential Use of Statins in Reducing Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery Satoshi Muraki, Nobuyoshi Kawaharada, Tetsuya Higami ········· 1798 51. Role of Renin-Angiotensin System Inhibitors in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting

Circulation Journal Vol.74, December 2010 vi Contents of Volume 74, 2010

Takeshi Kinoshita, Tohru Asai ········· 1800 52. Is There an Evening Peak in the Occurrence of Out-of-Hospital Cardiac Arrest in Japanese? – Special Situations With Circadian Variation – Hiroshi Nonogi ········· 1802 53. Could Circulating Progenitor Cell Count Be a Barometer for Coronary Artery Disease Progression? Jeong Ae Park, Young-Guen Kwon ········· 1804 54. Class Differences in Calcium-Channel Blockers in Vasospastic Angina Sang Hong Baek ········· 1806 55. Biodegradable Polymer for Drug-Eluting Stents – A True Advantage or Only Perception? – Ron Waksman, Kohei Wakabayashi ········· 2052 56. Modifying the Drug Elution Profile for Neointimal Control – Distance and Accuracy Improved Simultaneously With a New Driver? – Yoshihiro Morino ········· 2054 57. Hypothetical Mechanism of the Improvement by Adaptive Servo-Ventilation of the Pathophysiology of Heart Failure Associated With Sleep-Disordered Breathing Hiroshi Asanuma, Masafumi Kitakaze ········· 2056 58. Carotid Stenosis, Baroreceptor Sensitivity and Cerebral Autoregulation – Implication for Cerebral Hyperperfusion Syn- drome – Kazuo Kitagawa ········· 2058 59. Influenza Myocarditis Makoto Kodama ········· 2060 60. Dose-Dependent Reduction in Pulmonary Vascular Resistance With Epoprostenol in Pulmonary Arterial Hypertension Satoshi Homma ········· 2062 61. Soluble Fms-Like Tyrosine Kinase-1 – A Novel Marker for Atherosclerotic Progression? – Burak Pamukcu, Eduard Shantsila, Gregory Y.H. Lip ········· 2064 62. Resume Driving After a Refueling Pit Stop Yasushi Oginosawa, Haruhiko Abe, Ritsuko Kohno, Hitoshi Minamiguchi ········· 2283 63. Nifekalant Hydrochloride for Patients With Cardiac Arrest Caused by Shockable Rhythm Ken Nagao ········· 2285 64. Combined Renin-Angiotensin System-Inhibition Therapy – What Really Accounts for the Additive Benefits? – Shoji Sanada, Masafumi Kitakaze ········· 2288 65. Still Searching for a New Therapeutic Strategy for Acute Myocardial Infarction Yoshihiko Saito ········· 2290 66. Impaired Coronary Vasomotion After Coronary Intervention With Drug-Eluting Stents Masaharu Ishihara ········· 2293 67. Cytoskeletal Proteins – Hidden Targets of Cytoprotective Signaling? – Tetsuji Miura ········· 2295 68. Excessive Apoptosis as a Downstream Molecular Event During the Development of Congenital Heart Diseases Shinji Kaichi, Koji Hasegawa, Tatsuya Morimoto ········· 2297 69. Developmental Origins of Cardiovascular Disease – Cholesterol Metabolism and Higher Carotid Artery Intima-Media Thickness in Young Adults Born Small for Gestational Age – Tomoo Okada ········· 2299 70. Gene Mutations Associated With Atrioventricular Block Complicated by Long QT Syndrome Mitsuhiro Nishizaki, Masayasu Hiraoka ········· 2546 71. Exercise Training in Post-CABG Patients at Low Prognostic Risk – Beyond Recovery From Surgery – Yoichi Goto ········· 2548 72. Metabolic Syndrome and Heart Failure Kazuhiro Yamamoto ········· 2550 73. Sympathoinhibitory Effects of Atorvastatin in Hypertension Takuya Kishi, Yoshitaka Hirooka ········· 2552 74. Is What You See in Color Intravascular Ultrasound What You Want to Get? Takafumi Hiro ········· 2554 75. The Nitric Oxide Synthase Family and Left Ventricular Diastolic Function Yasuchika Takeishi ········· 2556 76. Does Remodeling of Gap Junctions and Connexin Expression Contribute to Arrhythmogenesis? – Study in an Immobi- lization Rat Model – Hideharu Hayashi ········· 2558 77. Energy States in Mitochondrial Cardiomyopathy – In Vivo Functional Imaging and L-Arginine Therapy – Masamichi Ikawa, Makoto Yoneda, Masashi Tanaka ········· 2560

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 vii

Original Articles

Aortic Disease 1. Combined Assessment of Carotid Vulnerable Plaque, Renal Insufficiency, Eosinophilia, and hs-CRP for Predicting Risky Aortic Plaque of Cholesterol Crystal Embolism Tomoko Machino-Ohtsuka, Yoshihiro Seo, Tomoko Ishizu, Yukio Sekiguchi, Akira Sato, Hiroshi Tada, Shigeyuki Watanabe, Kazutaka Aonuma ········· 51 2. Reduction of the PaO2/FiO2 Ratio in Acute Aortic Dissection – Relationship Between the Extent of Dissection and Inflammation – Manabu Kurabayashi, Kaoru Okishige, Koji Azegami, Daisuke Ueshima, Koji Sugiyama, Tsukasa Shimura, Minetaka Maeda, Hideshi Aoyagi, Mitsuaki Isobe ········· 2066 Arrhythmia/Electrophysiology 3. Radiofrequency Catheter Ablation of Atrial Tachycardia Under Navigation Using the EnSite Array Sumito Narita, Koji Miyamoto, Takeshi Tsuchiya, Yasutsugu Nagamoto, Takanori Yamaguchi ········· 59 4. Body Size and Atrial Fibrillation in Japanese Outpatients Shinya Suzuki, Takeshi Yamashita, Takayuki Ohtsuka, Koichi Sagara, Tokuhisa Uejima, Yuji Oikawa, Junji Yajima, Akira Koike, Kazuyuki Nagashima, Hajime Kirigaya, Ken Ogasawara, Hitoshi Sawada, Tsutomu Yamazaki, Tadanori Aizawa ········· 66 5. Comparison of Antiarrhythmics Used in Patients With Paroxysmal Atrial Fibrillation – Subanalysis of J-RHYTHM Study – Yoshiyasu Aizawa, Shun Kohsaka, Shinya Suzuki, Hirotsugu Atarashi, Shiro Kamakura, Masayuki Sakurai, Haruaki Nakaya, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki, Takeshi Yamashita, Satoshi Ogawa, J-RHYTHM Investigators ········· 71 6. Novel ECG Predictor of Difficult Cases of Outflow Tract Ventricular Tachycardia – Peak Deflection Index on an Infe- rior Lead – Hitoshi Hachiya, Kenzo Hirao, Takeshi Sasaki, Koji Higuchi, Tatsuya Hayashi, Yasuaki Tanaka, Mihoko Kawabata, Mitsuaki Isobe ········· 256 7. Recruitment of Immune Cells Across Atrial Endocardium in Human Atrial Fibrillation Takeshi Yamashita, Akiko Sekiguchi, Yu-ki Iwasaki, Taro Date, Koichi Sagara, Hiroaki Tanabe, Hisayoshi Suma, Hitoshi Sawada, Tadanori Aizawa ········· 262 8. Prevalence of the Brugada-Type Electrocardiogram and Incidence of Brugada Syndrome in Patients With Sick Sinus Syndrome Hidemori Hayashi, Masataka Sumiyoshi, Masayuki Yasuda, Kaoru Komatsu, Gaku Sekita, Yasunobu Kawano, Takashi Tokano, Yuji Nakazato, Hiroyuki Daida ········· 271 9. Mechanism of Regular Atrial Tachyarrhythmias During Combined Pulomonary Vein Isolation and Complex Fraction- ated Electrogram Ablation in Patients With Atrial Fibrillation Gi-Byoung Nam, Eun-Sun Jin, HyungOh Choi, Hae-Geun Song, Sung-Hwan Kim, Ki-Hun Kim, Eui-Seock Hwang, Kyoung-Min Park, Jun Kim, Kyoung-Suk Rhee, Kee-Joon Choi, You-Ho Kim ········· 434 10. Protective Effects of Estrogen Against Reperfusion Arrhythmias Following Severe Myocardial Ischemia in Rats Yan Wang, Qi Wang, Yingnan Zhao, Dezheng Gong, Dongmei Wang, Cong Li, Henan Zhao ········· 634 11. Risks and Benefits of an Open Irrigation Tip Catheter in Intensive Radiofrequency Catheter Ablation in Patients With Non-Paroxysmal Atrial Fibrillation Eui-Seock Hwang, Hui-Nam Pak, Sang Weon Park, Jong Sung Park, Boyoung Joung, Donghoon Choi, Moon-Hyoung Lee, Young Hoon Kim ········· 644 12. Sex-Related Differences in the Risk Factor Profile and Medications of Patients With Atrial Fibrillation Recruited in J- TRACE Hiroshi Inoue, Takashi Nozawa, Tadakazu Hirai, Shinya Goto, Hideki Origasa, Kazuyuki Shimada, Shinichiro Uchiyama, Takayuki Hirabayashi, Yukihiro Koretsune, Shiro Ono, Tooru Hasegawa, Yasuo Sasagawa, Yoshiaki Kaneko, Yasuo Ikeda for the J-TRACE Investigators ········· 650 13. Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat Zhaoliang Shan, Junjin Yan, Junyan Zhou, Xiangmin Shi, Jianping Guo, Hongtao Yuan, Maurits A. Allessie, Yutang Wang ········· 655 14. Abnormal Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Brugada Syndrome Sonoko Ashino, Ichiro Watanabe, Masayoshi Kofune, Koichi Nagashima, Kimie Ohkubo, Yasuo Okumura, Toshiko Nakai, Yuji Kasamaki, Atsushi Hirayama ········· 664 15. Effects of Landiolol, an Ultra-Short-Acting β1-Selective Blocker, on Electrical Storm Refractory to Class III Antiarrhyth- mic Drugs Yosuke Miwa, Takanori Ikeda, Hisaaki Mera, Mutsumi Miyakoshi, Kyoko Hoshida, Ryoji Yanagisawa, Haruhisa Ishiguro, Takehiro Tsukada, Atsuko Abe, Satoru Yusu, Hideaki Yoshino ········· 856 16. Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia – Retrospec- tive Case Series – Satoru Komura, Masaomi Chinushi, Hiroshi Furushima, Yukio Hosaka, Daisuke Izumi, Kenichi Iijima, Hiroshi Watanabe, Nobue Yagihara, Yoshifusa Aizawa ········· 864 17. Impact of Drug Alteration to Maintain Rhythm Control in Paroxysmal Atrial Fibrillation – Subanalysis From J-RHYTHM Study –

Circulation Journal Vol.74, December 2010 viii Contents of Volume 74, 2010

Ayaka Endo, Shun Kohsaka, Shinya Suzuki, Hirotsugu Atarashi, Shiro Kamakura, Masayuki Sakurai, Haruaki Nakaya, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki, Takeshi Yamashita, Satoshi Ogawa, J-RHYTHM Investigators ········· 870 18. Importance of Morphological Changes in T-U Waves During Bepridil Therapy as a Predictor of Ventricular Arrhythmic Event Sayaka Kurokawa, Shinichi Niwano, Michiro Kiryu, Masami Murakami, Shoko Ishikawa, Yoshihiro Yumoto, Masahiko Moriguchi, Hiroe Niwano, Tomoko Kosukegawa, Tohru Izumi ········· 876 19. Effect of Epicardial Fat Pad Ablation on Acute Atrial Electrical Remodeling and Inducibility of Atrial Fibrillation Dong Chang, Shulong Zhang, Donghui Yang, Lianjun Gao, Yubi Lin, Zhenliang Chu, Xiaoxiao Jiang, Xiaomeng Yin, Zhitao Zheng, Xianjing Wei, Dejun You, Xianjie Xiao, Peixin Cong, Xiaoming Bian, Yunlong Xia, Yanzong Yang ········· 885 20. Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation – Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration – Kenichi Iijima, Masaomi Chinushi, Daisuke Izumi, Shizue Ahara, Hiroshi Furushima, Satoru Komura, Yukio Hosaka, Akiko Sanada, Akinori Sato, Yoshifusa Aizawa ········· 895 21. Transesophageal Echocardiography for Thrombus Screening Prior to Left Atrial Catheter Ablation Eiji Yamashita, Hiroto Takamatsu, Hiroshi Tada, Hiroyuki Toide, Hiroki Okaniwa, Naoki Takemura, Takehito Sasaki, Yuko Miki, Etsuko Fuke, Tatsuya Hayashi, Tamotsu Sakamoto, Koki Nakamura, Rie Fukazawa, Chizuru Sato, Koji Goto, Kenichi Kaseno, Koji Kumagai, Shigeto Naito, Hiroshi Hoshizaki, Shigeru Oshima ········· 1081 22. Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats Kana Unuma, Kaori Shintani-Ishida, Kensuke Tsushima, Tatsuo Shimosawa, Takashi Ueyama, Masayoshi Kuwahara, Ken-ichi Yoshida ········· 1087 23. Long-Term Effects of Box Isolation on Sympathovagal Balance in Atrial Fibrillation Yoshio Yamaguchi, Koichiro Kumagai, Hideko Nakashima, Keijiro Saku ········· 1096 24. Relationship Between Oral Amiodarone and Inappropriate Therapy From an Implantable Cardioverter Defibrillator Takayuki Nagai, Kazuhiro Satomi, Takashi Noda, Hideo Okamura, Yuko Yamada, Wataru Shimizu, Kazuhiro Suyama, Naohiko Aihara, Shiro Kamakura, Takashi Kurita ········· 1302 25. Single-Site Bachmann’s Bundle Pacing Is Beneficial While Coronary Sinus Pacing Results in Echocardiographic Right Heart Pacemaker Syndrome in Brady-Tachycardia Patients Alicja Da˛browska-Kugacka, Ewa Lewicka-Nowak, Piotr Ruci´nski, Dariusz Kozłowski, Grzegorz Raczak, Andrzej Kutarski ········· 1308 26. High-Normal Thyroid Function and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation Ri-Bo Tang, Dong-Ling Liu, Jian-Zeng Dong, Xing-Peng Liu, De-Yong Long, Rong-Hui Yu, Fu-Li Hu, Jia-Hui Wu, Xiao-Hui Liu, Chang-Sheng Ma ········· 1316 27. Radiofrequency Catheter Ablation of Ventricular Tachyarrhythmia Under Navigation Using EnSite Array Koji Miyamoto, Takeshi Tsuchiya, Sumito Narita, Yasutsugu Nagamoto, Takanori Yamaguchi, Shin-ichi Ando, Kiyoshi Hayashida, Yoshito Tanioka, Naohiko Takahashi ········· 1322 28. Thickening of the Left Atrial Wall Shortly After Radiofrequency Ablation Predicts Early Recurrence of Atrial Fibrillation Miki Yokokawa, Hiroshi Tada, Keiko Koyama, Toshihiko Ino, Shigeto Naito, Shigeru Oshima, Koichi Taniguchi ········· 1538 29. Oxidative Stress on Pulmonary Vein and Left Atrium Arrhythmogenesis Yung-Kuo Lin, Feng-Zhi Lin, Yao-Chang Chen, Chen-Chuan Cheng, Cheng-I Lin, Yi-Jen Chen, Shih-Ann Chen ·········· 1547 30. Characteristics of Complex Fractionated Atrial Electrogram in the Electroanatomically Remodeled Left Atrium of Patients With Atrial Fibrillation Jae Hyung Park, Sang Weon Park, Jong Youn Kim, Sook Kyoung Kim, Boyoung Jeoung, Moon-Hyung Lee, Chun Hwang, Young-Hoon Kim, Sung Soon Kim, Hui-Nam Pak ········· 1557 31. Impact of Systemic Acidosis on the Development of Malignant Ventricular Arrhythmias After Reperfusion Therapy for ST-Elevation Myocardial Infarction Toshiyuki Nagai, Toshihisa Anzai, Hidehiro Kaneko, Atsushi Anzai, Yoshinori Mano, Yuji Nagatomo, Shun Kohsaka, Yuichiro Maekawa, Akio Kawamura, Tsutomu Yoshikawa, Satoshi Ogawa ········· 1808 32. Is Structural Remodeling of Fibrillated Atria the Consequence of Tissue Hypoxia? Hiroshi Ogi, Yukiko Nakano, Shumpei Niida, Keigo Dote, Yukoh Hirai, Kazuyosi Suenari, Yukiji Tonouchi, Noboru Oda, Yuko Makita, Shigeyuki Ueda, Kenta Kajihara, Katsuhiko Imai, Taijro Sueda, Kazuaki Chayama, Yasuki Kihara ········· 1815 33. Predictors of Electrical Storm in Patients With Idiopathic Dilated Cardiomyopathy – How to Stratify the Risk of Electri- cal Storm – Masateru Takigawa, Takashi Noda, Takashi Kurita, Naohiko Aihara, Yuko Yamada, Hideo Okamura, Kazuhiro Satomi, Kazuhiro Suyama, Wataru Shimizu, Shiro Kamakura ········· 1822 34. The Impact of Diastolic Dysfunction on the Atrial Substrate Properties and Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation Yu-Feng Hu, Tsui-Lieh Hsu, Wen-Chung Yu, Sung-Hao Huang, Hsuan-Ming Tsao, Ching-Tai Tai, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Ta-Chuan Tuan, Chien-Jung Chang, Wen-Chin Tsai, Pi-Chang Lee, Wei-Hua Tang, Shih-Ann Chen ········· 2074 35. Synergistic Dual Automaticity in Sinoatrial Node Cell and Tissue Models Hong Zhang, Boyoung Joung, Tetsuji Shinohara, Xi Mei, Peng-Sheng Chen, Shien-Fong Lin ········· 2079 36. Clinical Effect of Implantable Cardioverter Defibrillator Replacements – When Should You Resume Driving After an

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 ix

Implantable Cardioverter Defibrillator Replacement? – Hiro Kawata, Takashi Noda, Takashi Kurita, Kenichiro Yamagata, Yuko Yamada, Hideo Okamura, Kazuhiro Satomi, Wataru Shimizu, Kazuhiro Suyama, Naohiko Aihara, Mitsuaki Isobe, Shiro Kamakura ········· 2301 37. Report From J-PULSE Multicenter Registry of Patients With Shock-Resistant Out-of-Hospital Cardiac Arrest Treated With Nifekalant Hydrochloride Satoshi Yasuda, Hirotaka Sawano, Hiroshi Hazui, Isao Ukai, Hiroyuki Yokoyama, Junko Ohashi, Kazuhiro Sase, Akiko Kada, Hiroshi Nonogi on behalf of the J-PULSE Investigators ········· 2308 38. Atrioventricular Block-Induced Torsades de Pointes With Clinical and Molecular Backgrounds Similar to Congenital Long QT Syndrome Yuko Oka, Hideki Itoh, Wei-Guang Ding, Wataru Shimizu, Takeru Makiyama, Seiko Ohno, Yukiko Nishio, Tomoko Sakaguchi, Akashi Miyamoto, Mihoko Kawamura, Hiroshi Matsuura, Minoru Horie ········· 2562 39. SCN5A Mutation Is Associated With Early and Frequent Recurrence of Ventricular Fibrillation in Patients With Brugada Syndrome Nobuhiro Nishii, Masahiro Ogawa, Hiroshi Morita, Kazufumi Nakamura, Kimikazu Banba, Daiji Miura, Naoko Kumagai, Akira Matsunaga, Hiroshi Kawamura, Shigemi Urakawa, Kohei Miyaji, Masahiro Nagai, Katsumasa Satoh, Koji Nakagawa, Masamichi Tanaka, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Satoshi Nagase, Kunihisa Kohno, Kengo Fukushima Kusano, Keijiro Saku, Tohru Ohe, Hiroshi Ito ········· 2572 40. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model Shigeki Kobayashi, Masafumi Yano, Hitoshi Uchinoumi, Takeshi Suetomi, Takehisa Susa, Makoto Ono, Xiaojuan Xu, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Takeshi Yamamoto, Masunori Matsuzaki ········· 2579 Cardiovascular Intervention 41. Two-Year Clinical Outcome After Abciximab-Coated Stent Implantation in Patients With Coronary Artery Disease Sung Soo Kim, Young Joon Hong, Myung Ho Jeong, Weon Kim, Hyun-Kuk Kim, Jum Suk Ko, Min Goo Lee, Doo Sun Sim, Keun Ho Park, Nam Sik Yoon, Hyun Ju Yoon, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Sun-Jung Song, Dong Lyun Cho, Jung Chaee Kang ········· 442 42. A 3-Year Clinical Outcome After Percutaneous Coronary Intervention Using Sirolimus-Eluting Stent and Off-Pump Coronary Artery Bypass Grafting for the Treatment of Diabetic Patients With Multivessel Disease Ken-ichirou Yamagata, Yu Kataoka, Nobuaki Kokubu, Yoichiro Kasahara, Mitsuru Abe, Hiroyuki Nakajima, Junjiro Kobayashi, Yoritaka Otsuka ········· 671 43. Impact of High-Responsiveness to Dual Antiplatelet Therapy on Bleeding Complications in Patients Receiving Drug- Eluting Stents Kengo Tsukahara, Kazuo Kimura, Satoshi Morita, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Jun Okuda, Noriaki Iwahashi, Nobuhiko Maejima, Tatsuya Nakachi, Fumiyuki Ohtsuka, Katsutaka Hashiba, Yoshio Tahara, Teruyasu Sugano, Satoshi Umemura ········· 679 44. Anatomical Study of Forearm Arteries With Ultrasound for Percutaneous Coronary Procedures Zhen-xian Yan, Yu-jie Zhou, Ying-xin Zhao, Zhi-ming Zhou, Shi-wei Yang, Zhi-jian Wang ········· 686 45. Long-Term Clinical Outcome of Chronic Total Occlusive Lesions Treated With Drug-Eluting Stents – Comparison of Sirolimus-Eluting and Paclitaxel-Eluting Stents – Seung-Pyo Lee, Song-Yi Kim, Kyung-Woo Park, Dong-Ho Shin, Hyun-Jae Kang, Bon-Kwon Koo, Jung-Won Suh, Young-Seok Cho, Tae-Jin Yeon, In-Ho Chae, Dong-Ju Choi, Hyo-Soo Kim ········· 693 46. Comparison of Different Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation Fei Gao, Yu Jie Zhou, Zhi Jian Wang, Hua Shen, Xiao Li Liu, Bin Nie, Zhen Xian Yan, Shi Wei Yang, De An Jia, Miao Yu ········· 701 47. Comparison by Optical Coherence Tomography of Paclitaxel-Eluting Stents With Sirolimus-Eluting Stents Implanted in One Coronary Artery in One Procedure – 6-Month Follow-up – Naoki Miyoshi, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata ········· 903 48. High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Hirotaka Sawano, Daisaku Masuda, Shizuya Yamashita, Ken-ichiro Okada, Shoji Kaibe, Yasuyuki Hayashi, Tatsuro Kai, Toru Hayashi ········· 909 49. Late Progression After Sirolimus-Eluting Stent Implantation for de Novo Lesions – Comparison With Bare Metal Stent Implantation – Nobuo Shiode, Kinya Shirota, Fumiyo Tsunoda, Yasuko Kato, Mai Fujiwara, Asao Mimura ········· 1104 50. ‘Real World’ Comparison of Drug-Eluting Stents vs Bare Metal Stents in the Treatment of Unselected Patients With Acute ST-Segment Elevation Myocardial Infarction Kyung Woo Park, Si-Hyuck Kang, Woo-Young Chung, Hae-Young Lee, Jin-Shik Park, Hyun-Jae Kang, Young-Seok Cho, Tae-Jin Youn, Bon-Kwon Koo, In-Ho Chae, Dong-Ju Choi, Seokyung Hahn, Byung-Joo Park, Hyo-Soo Kim ········· 1111 51. Formation of Web- and Membrane-Like Structures on the Edges of Bare-Metal Coronary Stents Yasumi Uchida, Yasuto Uchida, Akimasa Matsuyama, Atsushi Koga, Masahito Kanai, Takeshi Sakurai ········· 1830 52. Comparison of Plain Balloon and Cutting Balloon Angioplasty for the Treatment of Restenosis With Drug-Eluting Stents vs Bare Metal Stents

Circulation Journal Vol.74, December 2010  Contents of Volume 74, 2010

Seung-Jung Park, Kyung-Hee Kim, Il-Young Oh, Dong-Ho Shin, Kyung-Il Park, Myung-Ki Seo, Jin-Wook Chung, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Tae-Jin Youn, Hyo-Soo Kim ········· 1837 53. STELLIUM 1: First-In-Man Follow-up Evaluation of Bioabsorbable Polymer-Coated Paclitaxel-Eluting Stent Amane Kozuki, Junya Shite, Toshiro Shinke, Naoki Miyoshi, Takahiro Sawada, Farrel Hellig, Mark Abelson, Basil Brown, Sajidah Khan, Martin Mpe, Mpiko Ntsekhe, Damian Conway, Ken-ichi Hirata ········· 2089 54. Short- and Mid-Term Intravascular Ultrasound Analysis of the New Zotarolimus-Eluting Stent With Durable Poly- mer – Results From the RESOLUTE Trial – Katsuhisa Waseda, Junya Ako, Masao Yamasaki, Tomomi Koizumi, John Ormiston, Stephen G. Worthley, Robert J. Whitbourn, Darren L. Walters, Yasuhiro Honda, Ian T. Meredith, Peter J. Fitzgerald, The RESOLUTE Trial Investigators ········· 2097 55. Three-Month Dual Antiplatelet Therapy After Implantation of Zotarolimus-Eluting Stents – The DATE (Duration of Dual Antiplatelet Therapy After Implantation of Endeavor Stent) Registry – Joo-Yong Hahn, Young Bin Song, Jin-Ho Choi, Sung-Hyuk Choi, Sung Yun Lee, Hun Sik Park, Seung Ho Hur, Sahng Lee, Kyoo-Rok Han, Seung-Woon Rha, Byung Ryul Cho, Jong-Sun Park, Junghan Yoon, Do Sun Lim, Sang Hoon Lee, Hyeon-Cheol Gwon for the DATE Registry Investigators ········· 2314 56. Long-Term Clinical Results and Predictors of Adverse Outcomes After Drug-Eluting Stent Implantation for Bifurcation Lesions in a Real-World Practice – The COBIS (Coronary Bifurcation Stenting) Registry – Hyeon-Cheol Gwon, Seung-Hyuk Choi, Young Bin Song, Joo-Yong Hahn, Myung-Ho Jeong, In-Whan Seong, Hyo-Soo Kim, Seung Woon Rha, Ju-Young Yang, Jung Han Yoon, Seung-Jea Tahk, Ki Bae Seung, Yangsoo Jang, Seung-Jung Park ········· 2322 57. Repeated Sirolimus-Eluting Stent Implantation to Treat Sirolimus-Eluting Stent and Bare-Metal Stent Restenosis Kensaku Nishihira, Yoshisato Shibata, Tetsunori Ishikawa, Katsumasa Nomura, Tatsuya Nakama, Daigo Mine, Yohei Inoue, Keiichi Ashikaga, Nehiro Kuriyama, Akihiko Matsuyama, Takuroh Imamura, Yujiro Asada, Kazuo Kitamura ········· 2329 58. Comparison of Vascular Response to Zotarolimus-Eluting Stent vs Paclitaxel-Eluting Stent Implantation – Pooled IVUS Results From the ZoMaxx I and II Trials – Katsuhisa Waseda, Takao Hasegawa, Junya Ako, Yasuhiro Honda, Eberhard Grube, Robert Whitbourn, John Ormiston, Charles D. O’Shaughnessy, Timothy D. Henry, Paul Overlie, Lewis B. Schwartz, Krishnankutty Sudhir, Bernard Chevalier, William A. Gray, Alan C. Yeung, Peter J. Fitzgerald for the ZoMaxx I and II Trial Investigators ········· 2334 59. Association Between Circulating Monocyte Subsets and In-Stent Restenosis After Coronary Stent Implantation in Patients With ST-Elevation Myocardial Infarction Yong Liu, Toshio Imanishi, Hideyuki Ikejima, Hiroto Tsujioka, Yuichi Ozaki, Akio Kuroi, Keishi Okochi, Kohei Ishibashi, Takashi Tanimoto, Yasushi Ino, Hironori Kitabata, Takashi Akasaka ········· 2585 60. Impact of Insulin-Treated Diabetes and Hemodialysis on Long-Term Clinical Outcomes Following Sirolimus-Eluting Stent Deployment – Insights From a Sub-Study of The Cypher Stent Japan Post-Marketing Surveillance (Cypher J-PMS) Registry – Masato Nakamura, Hiroyoshi Yokoi, Yuji Hamazaki, Masato Watarai, Mikihiro Kijima, Kazuaki Mitsudo for the Cypher J-PMS Investigators ········· 2592 Cardiac Rehabilitation 61. Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coro- nary Artery Disease Tomo Onishi, Kazunori Shimada, Hiroyuki Sato, Eriko Seki, Yoshiro Watanabe, Satoshi Sunayama, Hirotoshi Ohmura, Yoshiyuki Masaki, Miho Nishitani, Kosuke Fukao, Atsumi Kume, Takahiro Sumide, Hiroshi Mokuno, Hisashi Naito, Sachio Kawai, Hiroyuki Daida ········· 709 62. Influence of Dynamic Training on Hemodynamic, Neurohormonal Responses to Static Exercise and on Inflammatory Markers in Patients After Coronary Artery Bypass Grafting Maria Bilin´ska, Magdalena Kosydar-Piechna, Anna Ga˛siorowska, Tomasz Mikulski, Walerian Piotrowski, Krystyna Nazar, Ryszard Piotrowicz ········· 2598 Cardiovascular Surgery 63. Early Induction of Hypothermia During Cardiac Arrest Improves Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Who Undergo Emergency Cardiopulmonary Bypass and Percutaneous Coronary Intervention Ken Nagao, Kimio Kikushima, Kazuhiro Watanabe, Eizo Tachibana, Yoshiteru Tominaga, Katsushige Tada, Mitsuru Ishii, Nobutaka Chiba, Asuka Kasai, Taketomo Soga, Masakazu Matsuzaki, Kei Nishikawa, Yutaka Tateda, Harumi Ikeda, Tsukasa Yagi ········· 77 64. Diagnosis-Based Differences in Response of Global Ventricular Performance to Modified Ultrafiltration in Children Osami Honjo, Satoru Osaki, Yasuhiro Kotani, Teiji Akagi, Shunji Sano ········· 86 65. Tricuspid Annuloplasty Using the MC3 Ring for Functional Tricuspid Regurgitation Dong Seop Jeong, Kyung-Hwan Kim ········· 278 66. Optimal Placement of a Superior Vena Cava Cannula in Minimally Invasive Robot-Assisted Cardiac Surgery Yoon Kyung Lee, Ji Yeon Sim, Jung Wook Seo, In Cheol Choi, Kyung Don Hahm, Jae Woong Choi ········· 284 67. Mid-Term Results and Costs of Coronary Artery Bypass vs Drug-Eluting Stents for Unprotected Left Main Coronary Artery Disease Tsuyoshi Shimizu, Takayuki Ohno, Jiro Ando, Hideo Fujita, Ryozo Nagai, Noboru Motomura, Minoru Ono, Shunei Kyo, Shinichi Takamoto ········· 449 68. Risk Factor Analysis of Long-Term Support With Left Ventricular Assist System Shunsuke Saito, Goro Matsumiya, Taichi Sakaguchi, Shigeru Miyagawa, Yasushi Yoshikawa, Takashi Yamauchi,

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 xi

Toru Kuratani, Yoshiki Sawa ········· 715 69. Myocardial Transfection of Hypoxia Inducible Factor-1α via an Adenoviral Vector During Coronary Artery Bypass Grafting – A Multicenter Phase I and Safety Study – Eckehard Gerd Kilian, Sebastian Sadoni, Calin Vicol, Ralph Kelly, Karen van Hulst, Markus Schwaiger, Christian Kupatt, Peter Boekstegers, Ravi Pillai, Keith Channon, Roland Hetzer, Bruno Reichart ········· 916 70. Outcomes Following Use of a Modified Duran Ring Tricuspid Valve Reconstruction Procedure for Secondary Tricuspid Regurgitation Sung-Ho Jung, Hyung Gon Je, Jong Min Song, Suk Jung Choo, Cheol Hyun Chung, Sung Cheol Yun, Jae Won Lee ········· 925 71. Metabolic Syndrome as a Risk Factor for Postoperative Kidney Injury After Off-Pump Coronary Artery Bypass Surgery Soonchang Hong, Young-Nam Youn, Kyung-Jong Yoo ········· 1121 72. Mid-Term Results of the Cox Maze III Procedure Combined With Open Mitral Commissurotomy for the Treatment of Rheumatic Mitral Stenosis Hyungtae Kim, Pyo Won Park, Kiick Sung, Young-Tak Lee, Tae-Gook Jun, Wook Sung Kim, Ji-Hyuk Yang, Joomin Hwang ········· 1332 73. Correlation of Akinesia With Graft Patency and Cardiac Enzyme After Off-Pump Coronary Artery Bypass Graft Surgery Hongseok Yang, Young-Nam Youn, Kyung Jong Yoo ········· 1564 74. Statin for Prevention of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting in Japanese Patients Takeshi Kinoshita, Tohru Asai, Osamu Nishimura, Norihiko Hiramatsu, Tomoaki Suzuki, Atsushi Kambara, Keiji Matsubayashi ········· 1846 75. Effects of Renin-Angiotensin System Inhibitors on the Occurrence of Acute Kidney Injury Following Off-Pump Coro- nary Artery Bypass Grafting Young Chul Yoo, Young-Nam Youn, Jae Kwang Shim, Jong Chan Kim, Na Young Kim, Young Lan Kwak ········· 1852 76. Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery Takashi Komatsu, Hideaki Tachibana, Yoshihiro Satoh, Mahito Ozawa, Fusanori Kunugita, Atsushi Tashiro, Hitoshi Okabayashi, Motoyuki Nakamura ········· 1859 77. Preoperative Renal Dysfunction and Mortality After Off-Pump Coronary Artery Bypass Grafting in Japanese Takeshi Kinoshita, Tohru Asai, Yoshitaka Murakami, Tomoaki Suzuki, Atsushi Kambara, Keiji Matsubayashi ········· 1866 78. Combination of Irbesartan and Amiodarone to Maintain Sinus Rhythm in Patients With Persistent Atrial Fibrillation After Rheumatic Valve Replacement Qiang Ji, Yunqing Mei, Xisheng Wang, Jing Feng, Dewei Wusha, Jianzhi Cai, Yifeng Sun, Shiliang Xie ········· 1873 79. Gender Differences in Clinical and Angiographic Outcomes After Coronary Artery Bypass Surgery Toshihiro Fukui, Shuichiro Takanashi ········· 2103 80. Preoperative Left Atrial Mechanical Dysfunction Predicts Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Operation – A Velocity Vector Imaging-Based Study – Yelda Tayyareci, Ozlem Yildirimtürk, Vedat Aytekin, Kadriye Memic, Fusun Behramoglu, I.C. Cemsid Demiroglu, Saide Aytekin ········· 2109 81. Preoperative Indexed Left Ventricular Dimensions to Predict Early Recovery of Left Ventricular Function After Aortic Valve Replacement for Chronic Aortic Regurgitation Sang-Ho Cho, Chun-Sung Byun, Kwan-Wook Kim, Byung-Chul Chang, Kyung-Jong Yoo, Sak Lee ········· 2340 Critical Care 82. Latest Management and Outcomes of Major Pulmonary Embolism in the Cardiovascular Disease Early Transport System – Tokyo CCU Network – Tokyo CCU Network Scientific Committee ········· 289 83. Diagnostic Performance of a New Multifunctional Electrocardiograph During Uninterrupted Chest Compressions in Cardiac Arrest Patients Genji Shimpuku, Naoto Morimura, Tetsuya Sakamoto, Takaaki Isshiki, Shinya Nagata, Takahisa Goto ········· 1339 84. Circadian Variation in Out-of-Hospital Cardiac Arrests due to Cardiac Cause in a Japanese Patient Population Takehiro Tsukada, Takanori Ikeda, Haruhisa Ishiguro, Atsuko Abe, Mutsumi Miyakoshi, Yosuke Miwa, Hisaaki Mera, Satoru Yusu, Yoshihiro Yamaguchi, Hideaki Yoshino ········· 1880 85. Effects of Continuous Venovenous Hemofiltration on the Pharmacology of Carperitide, a Recombinant Human Atrial Natriuretic Peptide Ryoko Takahashi, Akinori Uchiyama, Naoya Iguchi, Takashi Mashimo, Yuji Fujino ········· 1888 86. Accuracy of Pulse Checks in Terms of Basic Life Support by Lifesavers, as Lay Persons Yoshihide Nakagawa, Sadaki Inokuchi, Seiji Morita, Kazuki Akieda, Arito Kaji, Tsutomu Komine, Yuumi Inagaki, Toshiharu Yamamoto ········· 1895 Epidemiology 87. Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan – Report From the MIYAGI-AMI Registry Study – Toru Takii, Satoshi Yasuda, Jun Takahashi, Kenta Ito, Nobuyuki Shiba, Kunio Shirato, Hiroaki Shimokawa on behalf of the MIYAGI-AMI Study Investigators ········· 93 88. Association Between Green Tea Intake and Coronary Artery Disease in a Chinese Population Qi-Ming Wang, Qing-Yue Gong, Jian-Jun Yan, Jun-Zhu, Jian-Jin Tang, Ming-Wei Wang, Zhi-Jian Yang, Lian-Sheng

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Wang ········· 294 89. Impact of Blood Pressure and Other Components of the Metabolic Syndrome on the Development of Cardiovascular Disease Guodong Kang, Lu Guo, Zhirong Guo, Xiaoshu Hu, Ming Wu, Zhengyuan Zhou, Hui Zhou, Shijun Liu, Fengmei Chen ········· 456 90. Does Obesity Attenuate the Effect of Metabolic Syndrome on Chronic Kidney Disease in Patients With Coronary Artery Disease? Report From China Heart Survey Hao Liu, Jinming Yu, Fang Chen, Jinsong Wang, Shengbao Chen, Fang Wang, Dayi Hu ········· 462 91. Associations Between Lipid Measures and Metabolic Syndrome, Insulin Resistance and Adiponectin – Usefulness of Lipid Ratios in Korean Men and Women – Heejin Kimm, Sang Wha Lee, Hong Soo Lee, Kyung Won Shim, Choo Yon Cho, Ji Eun Yun, Sun Ha Jee ········· 931 92. Serum Total and Non-High-Density Lipoprotein Cholesterol and the Risk Prediction of Cardiovascular Events – The JALS-ECC – Naohito Tanabe, Hiroyasu Iso, Katsutoshi Okada, Yasuyuki Nakamura, Akiko Harada, Yasuo Ohashi, Takashi Ando, Hirotsugu Ueshima for the Japan Arteriosclerosis Longitudinal Study Group ········· 1346 93. Appropriate Waist Circumference Cut-Offs to Predict Diabetes in the Korean Population – The Korean Genome and Epidemiology Study – Sun-Ja Choi, Bhumsuk Keam, Sung-Hee Park, Hyun-Young Park ········· 1357 94. Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students Minoru Hongo, Hiroya Hidaka, Shigeko Sakaguchi, Keisuke Nakanishi, Motoki Ichikawa, Naoko Hirota, Naoki Tanaka, Goro Tsuruta, Yoshikazu Yazaki, Osamu Kinoshita, Uichi Ikeda, Kenichi Koike on behalf of the Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu ········· 1570 Heart Failure 95. Alterations in Left Ventricular Untwisting With Ageing Bas M. van Dalen, Osama I.I. Soliman, Floris Kauer, Wim B. Vletter, Heleen B. van der Zwaan, Folkert J. ten Cate, Marcel L. Geleijnse ········· 101 96. Inhibition of Endostatin/Collagen XVIII Deteriorates Left Ventricular Remodeling and Heart Failure in Rat Myocardial Infarction Model Kazuya Isobe, Keiji Kuba, Yasuhiro Maejima, Jun-ichi Suzuki, Shunichiro Kubota, Mitsuaki Isobe ········· 109 97. Overexpression of Myosin Phosphatase Reduces Ca2+ Sensitivity of Contraction and Impairs Cardiac Function Hideo Mizutani, Ryuji Okamoto, Nobuyuki Moriki, Katsuhisa Konishi, Masaya Taniguchi, Satoshi Fujita, Kaoru Dohi, Katsuya Onishi, Noboru Suzuki, Shinji Satoh, Naoki Makino, Takeo Itoh, David J. Hartshorne, Masaaki Ito ········· 120 98. Iron Regulatory Hormone Hepcidin Decreases in Chronic Heart Failure Patients With Anemia Mika Matsumoto, Takeshi Tsujino, Masaaki Lee-Kawabata, Yoshiro Naito, Hirokuni Akahori, Tsuyoshi Sakoda, Mitsumasa Ohyanagi, Naohisa Tomosugi, Tohru Masuyama ········· 301 99. Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts Tomohide Takaya, Hiromichi Wada, Tatsuya Morimoto, Yoichi Sunagawa, Teruhisa Kawamura, Rieko Takanabe-Mori, Akira Shimatsu, Yoshiko Fujita, Yuko Sato, Masatoshi Fujita, Takeshi Kimura, Tatsuya Sawamura, Koji Hasegawa ········· 723 100. Comparative Effects of Carvedilol vs Bisoprolol for Severe Congestive Heart Failure – Special Reference to Atrial Fibrillation – Masanori Konishi, Go Haraguchi, Shigeki Kimura, Hiroshi Inagaki, Mihoko Kawabata, Hitoshi Hachiya, Kenzo Hirao, Mitsuaki Isobe ········· 1127 101. Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Hisashi Yokoshiki, Sanae Hamaguchi, Takashi Yokota, Daisuke Goto, Kazutomo Goto, Akira Takeshita, Hiroyuki Tsutsui and for the JCARE-CARD Investigators ········· 1364 102. Complete Elimination of Cardiodepressant IgG3 Autoantibodies by Immunoadsorption in Patients With Severe Heart Failure Akiyasu Baba, Makoto Akaishi, Megumi Shimada, Toshiaki Monkawa, Yasuhisa Wakabayashi, Michiko Takahashi, Yuji Nagatomo, Tsutomu Yoshikawa ········· 1372 103. Differential Effects of Carvedilol and Metoprolol on Renal Function in Patients With Heart Failure Hiroyuki Ito, Yuji Nagatomo, Takashi Kohno, Toshihisa Anzai, Tomomi Meguro, Satoshi Ogawa, Tsutomu Yoshikawa ········· 1578 104. Irrelevant B-Type Natriuretic Peptide Levels in Patients With Mechanical Prostheses in the Mitral Position Presenting With Congestive Heart Failure Kensaku Higashi, Hideki Tanaka, Hiroto Shimokawahara, Norihito Nuruki, Katsuro Kashima, Masahiro Sonoda, Kazuhiko Nakamura, Hirohito Tsubouchi ········· 1584 105. Impact of Arterial Load on Left Ventricular Diastolic Function in Patients Undergoing Cardiac Catheterization for Coro- nary Artery Disease Hidekatsu Fukuta, Nobuyuki Ohte, Kazuaki Wakami, Kaoru Asada, Toshihiko Goto, Seiji Mukai, Tomomitsu Tani, Genjiro Kimura ········· 1900 106. Beneficial Effects of Adaptive Servo Ventilation in Patients With Chronic Heart Failure Takashi Koyama, Hiroyuki Watanabe, Yusuke Kobukai, Shin Makabe, Yoshiko Munehisa, Kenji Iino, Toshimitsu Kosaka, Hiroshi Ito ········· 2118 107. Addition of Losartan to Angiotensin-Converting Enzyme Inhibitors Improves Insulin Resistance in Patients With Chronic

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Heart Failure Treated Without β-Blockers Kazuhide Ogino, Masahiko Kato, Yoshiyuki Furuse, Yoshiharu Kinugasa, Yasuhiro Kaetsu, Einosuke Mizuta, Shinobu Sugihara, Katsunori Ishida, Kiyotaka Yanagihara, Ichiro Hisatome, Chiaki Shigemasa ········· 2346 108. Body Mass Index Is an Independent Predictor of Long-Term Outcomes in Patients Hospitalized With Heart Failure in Japan – A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) – Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Daisuke Goto, Takashi Yokota, Kazutomo Goto, Satoshi Yamada, Hisashi Yokoshiki, Akira Takeshita, Hiroyuki Tsutsui for the JCARE-CARD Investigators ········· 2605 109. Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure – Report From MetS-CHF Study – Yutaka Miura, Yoshihiro Fukumoto, Nobuyuki Shiba, Toshiro Miura, Kazunori Shimada, Yoshitaka Iwama, Atsutoshi Takagi, Hidenori Matsusaka, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Masanori Asakura, Shuichi Okamatsu, Hiroyuki Tsutsui, Hiroyuki Daida, Masunori Matsuzaki, Hitonobu Tomoike, Hiroaki Shimokawa ········· 2612 Hypertension and Circulatory Control 110. Impaired Erythrocyte Filterability of Spontaneously Hypertensive Rats – Investigation by Nickel Mesh Filtration Tech- nique – Kyoko Ariyoshi, Toru Maruyama, Keita Odashiro, Koichi Akashi, Takehiko Fujino, Nobuhiro Uyesaka ········· 129 111. Clinical Characteristics of Defecation Syncope Compared With Micturition Syncope Kaoru Komatsu, Masataka Sumiyoshi, Haruhiko Abe, Ritsuko Kohno, Hidemori Hayashi, Gaku Sekita, Takashi Tokano, Yuji Nakazato, Hiroyuki Daida ········· 307 112. Fluvastatin Attenuates Diabetes-Induced Cardiac Sympathetic Neuropathy in Association With a Decrease in Oxidative Stress Akira Matsuki, Takashi Nozawa, Norio Igarashi, Mitsuo Sobajima, Takashi Ohori, Takayuki Suzuki, Nozomu Fujii, Akihiko Igawa, Hiroshi Inoue ········· 468 113. Effects of Submaximal Exercise on Blood Rheology and Sympathetic Nerve Activity Nahoko Ikeda, Takanori Yasu, Ken Tsuboi, Yoshitaka Sugawara, Norifumi Kubo, Tomio Umemoto, Kenshiro Arao, Masanobu Kawakami, Shin-ichi Momomura ········· 730 114. Impact of Electrocardiographic Left Ventricular Hypertrophy on the Occurrence of Cardiovascular Events in Elderly Hypertensive Patients – The Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS) – Satoshi Jissho, Kenei Shimada, Haruyuki Taguchi, Ken Yoshida, Shota Fukuda, Hidemasa Tanaka, Junichi Yoshikawa, Minoru Yoshiyama, Masao Ishii, Yoshio Goto ········· 938 115. Association Between Exaggerated Blood Pressure Response to Exercise and Serum Asymmetric Dimethylarginine Levels Mehmet Kayrak, Ahmet Bacaksiz, Mehmet Akif Vatankulu, Selim S. Ayhan, Alparslan Taner, Ali Ünlü, Mehmet Yazici, Mehmet S. Ulgen ········· 1135 116. Baroreflex Sensitivity Predicts Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Structural Heart Disease Norihiro Okada, Naohiko Takahashi, Kunio Yufu, Yukichi Murozono, Osamu Wakisaka, Tetsuji Shinohara, Futoshi Anan, Mikiko Nakagawa, Masahide Hara, Tetsunori Saikawa, Hironobu Yoshimatsu ········· 1379 117. V-Shaped Trough in Autonomic Activity Is a Possible Precursor of Life-Threatening Cardiac Events Motohisa Osaka, Eiichi Watanabe, Hiroshige Murata, Yoshitaka Fuwamoto, Shinji Nanba, Kazuhiro Sakai, Takao Katoh ········· 1906 118. Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow Kentaro Toiyama, Kenji Hamaoka, Tatsujiro Oka, Naho Kobayashi, Kanae Noritake, Ryuichi Kato, Yoko Kawai, Seiichiro Ozawa, Masashi Nishida, Toshiyuki Itoi ········· 2125 119. Impact of Left Ventricular Hypertrophy on the Time-Course of Renal Function in Hypertensive Patients – A Subanalysis of the CASE-J Trial – Kenji Ueshima, Shinji Yasuno, Koji Oba, Akira Fujimoto, Masashi Mukoyama, Toshio Ogihara, Takao Saruta, Kazuwa Nakao ········· 2132 120. Autonomic Function and Cerebral Autoregulation in Patients Undergoing Carotid Endarterectomy Lars Mense, Manja Reimann, Heinz Rüdiger, Georg Gahn, Heinz Reichmann, Hjördis Hentschel, Tjalf Ziemssen ········· 2139 121. A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population Yumiko Hiura, Yasuharu Tabara, Yoshihiro Kokubo, Tomonori Okamura, Tetsuro Miki, Hitonobu Tomoike, Naoharu Iwai ········· 2353 122. Sympathoinhibition by Atorvastatin in Hypertensive Patients Marc E. Gomes, Cees J. Tack, Freek W. Verheugt, Paul Smits, Jacques W.M. Lenders ········· 2622 Imaging 123. Evaluation of Myocardial Bridge With Multidetector Computed Tomography So Yeon Kim, Young Soo Lee, Jin Bae Lee, Jae Kean Ryu, Ji Yong Choi, Sung Gug Chang, Kee-Sik Kim ········· 137 124. Evaluation of Subclinical Right Ventricular Dysfunction in Obstructive Sleep Apnea Patients Using Velocity Vector Imaging Aylin Tugcu, Ozlem Yildirimtürk, Yelda Tayyareci, Cemsid Demiroglu, Saide Aytekin ········· 312 125. Comparison of Neointimal Coverage of Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents Using Optical Coherence Tomography at 9 Months After Implantation Jin-Sun Kim, Jung-Sun Kim, Tae Hoon Kim, Chunyu Fan, Jung Myung Lee, Woong Kim, Young-Guk Ko, Donghoon

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Choi, Myeong-Ki Hong, Yangsoo Jang ········· 320 126. Delayed Enhancement Magnetic Resonance Imaging Is a Significant Prognostic Factor in Patients With Non-Ischemic Cardiomyopathy Jung Rae Cho, Sungha Park, Byoung Wook Choi, Seok-Min Kang, Jong-Won Ha, Namsik Chung, Kyu-Ok Choe, Seung-Yun Cho, Se-Joong Rim ········· 476 127. Prospective Electrocardiogram-Gated Axial 64-Detector Computed Tomographic Angiography vs Retrospective Gated Helical Technique to Assess Coronary Artery Bypass Graft Anastomosis – Comparison of Image Quality and Patient Radiation Dose – Haruhiko Machida, Ai Masukawa, Isao Tanaka, Rika Fukui, Kazufumi Suzuki, Eiko Ueno, Kojiro Kodera, Kiyoharu Nakano, Yun Shen ········· 735 128. Evaluation of Cardiac Allograft Vasculopathy by Multidetector Computed Tomography and Whole-Heart Magnetic Reso- nance Coronary Angiography Shinichi Nunoda, Haruhiko Machida, Akihiko Sekikawa, Kazunobu Shitakura, Kiyotaka Okajima, Yutaka Kubo, Eiko Ueno, Kuniaki Otsuka ········· 946 129. Relation Between Plaque Components and Plaque Prolapse After Drug-Eluting Stent Implantation – Virtual Histology – Intravascular Ultrasound – Young Joon Hong, Myung Ho Jeong, Sang Wook Kim, Yun Ha Choi, Eun Hae Ma, Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Yoon, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang ········· 1142 130. Prognostic Value of Post-Ischemic Stunning as Assessed by Gated Myocardial Perfusion Single-Photon Emission Com- puted Tomography – A Subanalysis of the J-ACCESS Study – Yasuhiro Usui, Taishiro Chikamori, Kenichi Nakajima, Satoshi Hida, Akira Yamashina, Tsunehiko Nishimura for the J-ACCESS Investigators ········· 1591 131. Strain Measurements During Adenosine Triphosphate Infusion Before and After Percutaneous Coronary Intervention Motoko Hosaka, Atsushi Takagi, Tsutomu Takagi, Kyomi Ashihara, Nobuhisa Hagiwara ········· 1600 132. Prognostic Value of Normal Stress Myocardial Perfusion Imaging and Ventricular Function in Japanese Asymptomatic Patients With Type 2 Diabetes – A Study Based on the J-ACCESS-2 Database – Shinro Matsuo, Kenichi Nakajima, Yoshimitsu Yamasaki, Atsunori Kashiwagi, Tsunehiko Nishimura ········· 1916 133. Volumetric Analysis of Coronary Plaque Characterization in Patients With Metabolic Syndrome Using 64-Slice Multi- Detector Computed Tomography Kosuke Arai, Hideki Ishii, Tetsuya Amano, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kiminobu Yokoi, Hirohiko Ando, Soichiro Kumagai, Ken Harada, Daiji Yoshikawa, Satoru Ohshima, Tatsuaki Matsubara, Toyoaki Murohara ········· 2146 134. Impact of Aortic Plaque Morphology on Survival Rate and Incidence of a Subsequent Embolic Event – Long-Term Follow- up Data – Chisato Izumi, Shuichi Takahashi, Makoto Miyake, Jiro Sakamoto, Koji Hanazawa, Kazuyasu Yoshitani, Kazuaki Kaitani, Toshiaki Izumi, Hiromitsu Gen, Yoshihisa Nakagawa ········· 2152 135. Automated Assessment of Myocardial Viability After Acute Myocardial Infarction by Global Longitudinal Peak Strain on Low-Dose Dobutamine Stress Echocardiography Katsuomi Iwakura, Atsushi Okamura, Yasushi Koyama, Motoo Date, Yoshiharu Higuchi, Koichi Inoue, Ryusuke Kimura, Hiroyuki Nagai, Michio Imai, Yuko Toyoshima, Makito Ozawa, Norihisa Ito, Yukinori Okazaki, Masahiko Shibuya, Shigemiki Omiya, Takashi Takagi, Daisuke Morisawa, Kenshi Fujii ········· 2158 136. Abnormal Myocardial Capillary Density in Apical Hypertrophic Cardiomyopathy Can Be Assessed by Myocardial Con- trast Echocardiography Jeonggeun Moon, In Jeong Cho, Chi Young Shim, Jong-Won Ha, Yangsoo Jang, Namsik Chung, Se-Joong Rim ········· 2166 137. Right Ventricular Infarction and Tissue Doppler Imaging – Insights From Acute Inferior Myocardial Infarction After Primary Coronary Intervention – Shih-Hung Hsiao, Kuan-Rau Chiou, Wei-Chun Huang, Chin-Chang Cheng, Feng-You Kuo, Ko-Long Lin, Shih-Kai Lin, Shoa-Lin Lin ········· 2173 138. Visualization of Lipid Components in Human Coronary Plaques Using Color Fluorescence Angioscopy Yasumi Uchida, Yasuto Uchida, Noriaki Kameda ········· 2181 139. Normalized Wall Index Specific and MRI-Based Stress Analysis of Atherosclerotic Carotid Plaques – A Study Com- paring Acutely Symptomatic and Asymptomatic Patients – Chengcheng Zhu, Zhongzhao Teng, Umar Sadat, Victoria E. Young, Martin J. Graves, Zhi Yong Li, Jonathan H. Gillard ········· 2360 140. Prevalence and Clinical Implication of Complex Atherosclerotic Plaque in the Descending Thoracic Aorta of Japanese Patients Assessed by Transesophageal Echocardiography Nobuhiko Haruki, Masaaki Takeuchi, Kyoko Kaku, Hidetoshi Yoshitani, Masahito Tamura, Haruhiko Abe, Masahiro Okazaki, Toshiyuki Ota, Yutaka Otsuji ········· 2627 141. Evaluating Microvascular Obstruction After Acute Myocardial Infarction Using Cardiac Magnetic Resonance Imaging and 201-Thallium and 99m-Technetium Pyrophosphate Scintigraphy Takayuki Onishi, Isshi Kobayashi, Yuko Onishi, Tomoyuki Kawashima, Hirotaka Muramoto, Hiroaki Nakamura, Yasutoshi Nagata, Shigeo Umezawa, Akihiro Niwa ········· 2633 142. Tissue Characterization of Coronary Plaques and Assessment of Thickness of Fibrous Cap Using Integrated Backscatter Intravascular Ultrasound – Comparison With Histology and Optical Coherence Tomography –

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Masanori Kawasaki, Arihiro Hattori, Yoshiyuki Ishihara, Munenori Okubo, Kazuhiko Nishigaki, Genzou Takemura, Masanao Saio, Tsuyoshi Takami, Shinya Minatoguchi ········· 2641 143. Assessment of the Aortic Root Using Real-Time 3D Transesophageal Echocardiography Kyoko Otani, Masaaki Takeuchi, Kyoko Kaku, Lissa Sugeng, Hidetoshi Yoshitani, Nobuhiko Haruki, Toshiyuki Ota, Victor Mor-Avi, Roberto M Lang, Yutaka Otsuji ········· 2649 Ischemic Heart Disease 144. Plaque Location in the Left Anterior Descending Coronary Artery and Tissue Characteristics in Angina Pectoris – An Integrated Backscatter Intravascular Ultrasound Study – Naohiro Komura, Kiyoshi Hibi, Ikuyoshi Kusama, Fumiyuki Otsuka, Takayuki Mitsuhashi, Mitsuaki Endo, Noriaki Iwahashi, Jun Okuda, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura ········· 142 145. Acute Impact of Right Ventricular Infarction on Early Hemodynamic Course After Inferior Myocardial Infarction Hiroto Shiraki, Hitoshi Yokozuka, Koji Negishi, Sousin Inoue, Tetsuo Takahashi, Masao Chino, Satoshi Ogawa ········· 148 146. Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease Bang-Gee Hsu, Yu-Chih Chen, Ru-Ping Lee, Chia-Chi Lee, Chung-Jen Lee, Ji-Hung Wang ········· 327 147. Relationship Between Multiple Plasma Biomarkers and Vulnerable Plaque Determined by Virtual Histology Intravas- cular Ultrasound Jong-Pil Park, Byoung Kwon Lee, Jae-Min Shim, Sung-Hwan Kim, Cheol Whan Lee, Duk-Hyun Kang, Myeong-Ki Hong ········· 332 148. Upregulation of Fractalkine and Its Receptor, CX3CR1, is Associated With Coronary Plaque Rupture in Patients With Unstable Angina Pectoris Hideyuki Ikejima, Toshio Imanishi, Hiroto Tsujioka, Manabu Kashiwagi, Akio Kuroi, Takashi Tanimoto, Hironori Kitabata, Kohei Ishibashi, Kenichi Komukai, Tatsuya Takeshita, Takashi Akasaka ········· 337 149. Documentation of Impaired Coronary Blood Flow in Chronic Obstructive Pulmonary Disease Patients Hatice Selcuk, Orhan Maden, Mehmet Timur Selcuk, Mehmet Kutlu Celenk, Bilal Geyik, Omac Tüfekcioglu ········· 346 150. Change in Ischemia-Modified Albumin and Its Clinical Significance During Exercise Stress Testing Dong-Hyeon Lee, Hui-Kyung Jeon, Hun-Jun Park, Woo-Seung Shin, Seung-Won Lee, Ho-Joong Youn, Chul-Min Kim, Hae Kyung Lee ········· 484 151. Coronary Score Adds Prognostic Information for Patients With Acute Coronary Syndrome Gang Huang, Jiang-long Zhao, Huaan Du, Xian-bin Lan, Yue-hui Yin ········· 490 152. Comparison of Case Fatality Rates for Acute Myocardial Infarction in Weekday vs Weekend Admissions in South Korea Jae Seok Hong, Hee Chung Kang, Sun Hee Lee ········· 496 153. Effects of Nicorandil on Cardiovascular Events in Patients With Coronary Artery Disease in The Japanese Coronary Artery Disease (JCAD) Study Shigeo Horinaka, Akihisa Yabe, Hiroshi Yagi, Toshihiko Ishimitsu, Tsutomu Yamazaki, Shinya Suzuki, Takahide Kohro, Ryozo Nagai for the JCAD Study Investigators ········· 503 154. Clinical Importance of Adherence to Treatment With Eicosapentaenoic Acid by Patients With Hypercholesterolemia Hideki Origasa, Mitsuhiro Yokoyama, Masunori Matsuzaki, Yasushi Saito, Yuji Matsuzawa on behalf of the JELIS Investigators, Japan ········· 510 155. Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients Takashi Katashima, Takahiko Naruko, Fumio Terasaki, Masatoshi Fujita, Kaoru Otsuka, Shougo Murakami, Akira Sato, Michiaki Hiroe, Yoshihiro Ikura, Makiko Ueda, Masaki Ikemoto, Yasushi Kitaura ········· 741 156. Mycotic DNA in Non-Atherosclerotic Aortic Wall of Coronary Patients Is Associated With sICAM-1 Expression Bogdan Jegier, Ryszard Jaszewski, Piotr Kurnatowski, Katarzyna Kuba, Malgorzata Lelonek ········· 749 157. Effect of Vessel Size on Lipid Content of Coronary Plaques Assessed by Integrated Backscatter Intravascular Ultrasound Young-Guk Ko, Jung-Woo Son, Sang Min Park, Jung-Sun Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang ········· 754 158. Coronary Plaque Regression and Lifestyle Modification in Patients Treated With Pravastatin – Assessment Mainly by Daily Aerobic Exercise and an Increase in the Serum Level of High-Density Lipoprotein Cholesterol – Shigemasa Tani, Ken Nagao, Takeo Anazawa, Hirofumi Kawamata, Shingo Furuya, Hiroshi Takahashi, Kiyoshi Iida, Michiaki Matsumoto, Takehiko Washio, Narimichi Kumabe, Atsushi Hirayama ········· 954 159. Beta-Blocker Prescription Among Japanese Cardiologists and Its Effect on Various Outcomes Takahide Kohro, Dobun Hayashi, Tsutomu Yamazaki, Ryozo Nagai, The JCAD Investigators ········· 962 160. Periodic Variation and Its Effect on Management and Prognosis of Korean Patients With Acute Myocardial Infarction Hyo Eun Park, Bon-Kwon Koo, Wonjae Lee, Youngjin Cho, Jin Sik Park, Ji-Yong Choi, Myung-Ho Jeong, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Chang-Wook Nam, Jae-Hwan Lee, Dong Hoon Choi, Taek Jong Hong, Jei Keon Chae, Jae Young Rhew, Kee Sik Kim, Hyo-Soo Kim, Byung-Hee Oh, Young Bae Park for KAMIR investigators ········· 970 161. Predictors of In-Hospital Prognosis After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Requiring Mechanical Support Devices Jun Shiraishi, Yoshio Kohno, Takahisa Sawada, Masayoshi Kimura, Makoto Ariyoshi, Akihiro Matsui, Mitsuo Takeda, Masayasu Arihara, Masayuki Hyogo, Takatomo Shima, Takashi Okada, Takeshi Nakamura, Satoaki Matoba, Hiroyuki Yamada, Akiyoshi Matsumuro, Makoto Kitamura, Keizo Furukawa, Hiroaki Matsubara on behalf of the AMI-Kyoto Multi-Center Risk Study Group ········· 1152 162. Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocar-

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dial Infarction Among Patients Treated With Trandolapril, Valsartan or Both Sakiko Miyazaki, Takatoshi Kasai, Katsumi Miyauchi, Tadashi Miyazaki, Yoshinori Akimoto, Atsutoshi Takagi, Kouichiro Aihara, Masaki Kawamura, Satoru Suwa, Satoshi Kojima, Masataka Sumiyoshi, Hiroyuki Daida ········· 1158 163. Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome – Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial) – Takafumi Hiro, Takeshi Kimura, Takeshi Morimoto, Katsumi Miyauchi, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki, Kazuo Kimura, Satoshi Saito, Tetsu Yamaguchi, Hiroyuki Daida, Masunori Matsuzaki for the JAPAN-ACS Investigators ········· 1165 164. Post-Reperfusion Enhancement of CD14+CD16– Monocytes and Microvascular Obstruction in ST-Segment Elevation Acute Myocardial Infarction Hiroto Tsujioka, Toshio Imanishi, Hideyuki Ikejima, Takashi Tanimoto, Akio Kuroi, Manabu Kashiwagi, Keishi Okochi, Kohei Ishibashi, Kenichi Komukai, Yasushi Ino, Hironori Kitabata, Takashi Akasaka ········· 1175 165. Association Between Circulating Monocytes and Coronary Plaque Progression in Patients With Acute Myocardial Infarction Naoki Nozawa, Kiyoshi Hibi, Mitsuaki Endo, Teruyasu Sugano, Toshiaki Ebina, Masami Kosuge, Kengo Tsukahara, Jun Okuda, Satoshi Umemura, Kazuo Kimura ········· 1384 166. Low-Density Lipoprotein-Cholesterol/High-Density Lipoprotein-Cholesterol Ratio Predicts Lipid-Rich Coronary Plaque in Patients With Coronary Artery Disease – Integrated-Backscatter Intravascular Ultrasound Study – Takumi Kimura, Tomonori Itoh, Tetsuya Fusazaki, Hiroki Matsui, Shoma Sugawara, Yoshinobu Ogino, Hiroshi Endo, Ken Kobayashi, Motoyuki Nakamura ········· 1392 167. Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Predicts Prognosis After Acute Coronary Syndrome – A Pilot Study – Noriaki Kume, Hirokazu Mitsuoka, Kazutaka Hayashida, Masaru Tanaka, Toru Kita ········· 1399 168. Coronary Flow Reserve Is a Comprehensive Indicator of Cardiovascular Risk Factors in Subjects With Chest Pain and Normal Coronary Angiogram Dong-Hyeon Lee, Ho-Joong Youn, Yun-Seok Choi, Chul-Soo Park, Jeong-Hwan Park, Hui-Kyung Jeon, Jae-Hyung Kim ········· 1405 169. Single-Dose Intravenous Administration of Recombinant Human Erythropoietin Is a Promising Treatment for Patients With Acute Myocardial Infarction – Randomized Controlled Pilot Trial of EPO/AMI-1 Study – Takuya Ozawa, Ken Toba, Hiroshi Suzuki, Kiminori Kato, Yoshitaka Iso, Yasushi Akutsu, Youichi Kobayashi, Youichi Takeyama, Naohiko Kobayashi, Norihiko Yoshimura, Kohei Akazawa, Yoshifusa Aizawa, EPO/AMI-1 Pilot Study Researchers ········· 1415 170. Non-Invasive Magnetocardiography for the Early Diagnosis of Coronary Artery Disease in Patients Presenting With Acute Chest Pain Hyukchan Kwon, Kiwoong Kim, Yong-Ho Lee, Jin-Mok Kim, Kwon Kyu Yu, Namsik Chung, Young-Guk Ko ········· 1424 171. Intravascular Ultrasound Criteria for Determination of Optimal Longitudinal Positioning of Sirolimus-Eluting Stents Yoshihiro Morino, Seiji Tamiya, Naoki Masuda, Yota Kawamura, Masakazu Nagaoka, Takashi Matsukage, Nobuhiko Ogata, Gaku Nakazawa, Teruhisa Tanabe, Yuji Ikari ········· 1609 172. Upstream vs Deferred Administration of Small-Molecule Glycoprotein IIb/IIIa Inhibitors in Primary Percutaneous Cor- onary Intervention for ST-Segment Elevation Myocardial Infarction – Insights From Randomized Clinical Trials – Lili Dong, Feng Zhang, Xianhong Shu ········· 1617 173. Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Inter- vention: A Prospective Randomized Trial – Five-Year Results of the IMPORTANT Study – Tomonori Itoh, Ken’ichi Fukami, Tomomi Suzuki, Takumi Kimura, Yoshinori Kanaya, Makoto Orii, Iwao Goto, Hiroki Matsui, Shoma Sugawara, Satoshi Nakajima, Tetsuya Fusazaki, Motoyuki Nakamura for the IMPORTANT investigators ········· 1625 174. Impact of Drug-Eluting Stents on Treatment Option Mix for Coronary Artery Disease in Japan Hiromasa Horiguchi, Hideo Yasunaga, Hideki Hashimoto, Shinya Matsuda ········· 1635 175. Comparative Study of Bezafibrate and Pravastatin in Patients With Coronary Artery Disease and High Levels of Remnant Lipoprotein Keita Sano, Takamitsu Nakamura, Mitsumasa Hirano, Yoshinobu Kitta, Tsuyoshi Kobayashi, Daisuke Fujioka, Yukio Saito, Toshiaki Yano, Kazuhiro Watanabe, Yosuke Watanabe, Hideto Mishina, Jyun-ei Obata, Ken-ichi Kawabata, Kiyotaka Kugiyama ········· 1644 176. Effect of Prodromal Angina Pectoris on the Infarct Progression in Patients With First ST-Elevation Acute Myocardial Infarction Tatsuya Maruhashi, Masaharu Ishihara, Ichirou Inoue, Takuji Kawagoe, Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Eisuke Kagawa, Kazuoki Dai, Junichi Matsushita, Hiroki Ikenaga ········· 1651 177. Target Lesion Thin-Cap Fibroatheroma Defined by Virtual Histology Intravascular Ultrasound Affects Microvascular Injury During Percutaneous Coronary Intervention in Patients With Angina Pectoris Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Yoji Neishi, Takahiro Kawamoto, Yoshinori Miyamoto, Koichiro Imai, Ken Saito, Tetsuo Tsuchiya, Akihiro Hayashida, Kiyoshi Yoshida ········· 1658 178. Stabilization and Regression of Coronary Plaques Treated With Pitavastatin Proven by Angioscopy and Intravascular Ultrasound – The TOGETHAR Trial – Kazuhisa Kodama, Sei Komatsu, Yasunori Ueda, Tadateru Takayama, Jyunji Yajima, Shinsuke Nanto, Hiroshi Matsuoka, Satoshi Saito, Atsushi Hirayama ········· 1922

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179. Circulating CD34+/133+ Progenitor Cells in Patients With Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention Kenshiro Arao, Takanori Yasu, Nobuhiro Ohmura, Yoshiaki Tsukamoto, Miho Murata, Norifumi Kubo, Tomio Umemoto, Nahoko Ikeda, Junya Ako, San-e Ishikawa, Masanobu Kawakami, Shin-ichi Momomura ········· 1929 180. Clinical Predictors of Culprit Plaque Rupture Assessed on Intravascular Ultrasound in Acute Coronary Syndrome Masaya Kato, Keigo Dote, Toru Naganuma, Shota Sasaki, Kentaro Ueda, Misa Okita, Yoshikazu Watanabe, Masato Kajikawa, Haruko Yokoyama, Akifumi Higashi ········· 1936 181. Prognostic Effects of Calcium Channel Blockers in Patients With Vasospastic Angina – A Meta-Analysis – Kazuhiko Nishigaki, Yukiko Inoue, Yoshio Yamanouchi, Yoshihiro Fukumoto, Satoshi Yasuda, Shozo Sueda, Hidenori Urata, Hiroaki Shimokawa, Shinya Minatoguchi ········· 1943 182. Comparison Between the Effect of Omeprazole and Rabeprazole on the Antiplatelet Action of Clopidogrel Suksiri Siriswangvat, Nakarin Sansanayudh, Surakit Nathisuwan, Duangchit Panomvana ········· 2187 183. Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After ST-Elevated Acute Myocardial Infarction (EPOC-AMI) – A Pilot, Randomized, Placebo-Controlled Study – Norimasa Taniguchi, Takeshi Nakamura, Takahisa Sawada, Kinya Matsubara, Keizo Furukawa, Mitsuyoshi Hadase, Yoshifumi Nakahara, Takashi Nakamura, Hiroaki Matsubara ········· 2365 184. Exercise Stress Test Results in Patients With Bare Metal Stents or Drug-Eluting Stents – Pathophysiological and Clinical Implications – Roberto Nerla, Antonio Di Monaco, Gregory A. Sgueglia, Irma Battipaglia, Giulia Careri, Gaetano Pinnacchio, Pierpaolo Tarzia, Gaetano Antonio Lanza, Filippo Crea ········· 2372 185. Fluffy Luminal Surface of the Non-Stenotic Culprit Coronary Artery in Patients With Acute Coronary Syndrome – An Angioscopic Study – Yasumi Uchida, Yasuto Uchida, Takeshi Sakurai, Masahito Kanai, Seiichiro Shirai, Tomomitsu Oshima, Atsushi Koga, Akimasa Matsuyama, Tsuyoshi Tabata ········· 2379 186. Primary Percutaneous Coronary Intervention Lowers the Incidence of Ischemic Mitral Regurgitation in Patients With Acute ST-Elevated Myocardial Infarction Sarah Chua, Judy Hung, Sheng-Ying Chung, Yu-Chun Lin, Morgan Fu, Chiung-Jen Wu, Chi-Ling Hang, Han-Tan Chai, Wen-Hao Liu, Cheng-Hsu Yang, Tzu-Hsien Tsai, Chien-Jen Chen, Hon Kan Yip ········· 2386 187. Diagnostic Value of Adenosine-Induced Left Ventricular Diastolic Dysfunction for Detecting Coronary Artery Restenosis in Patients Undergoing Stent Implantation by Stress ECG-Gated Myocardial Perfusion SPECT – A Pilot Study – Yoshimochi Nakano, Naoya Matsumoto, Yasuyuki Suzuki, Masahiko Kato, Takaaki Miki, Jun Iida, Shunichi Yoda, Keiko Sugiyama, Yuichi Sato, Shu Kasama, Toshio Kushiro, Ken Nagao, Atsushi Hirayama ········· 2658 188. Vasodilator Stress Impairs the Left Ventricular Function Obtained With Gated Single-Photon Emission Computed Tomography in Patients With Known or Suspected Coronary Artery Disease Keiichi Odagiri, Akihiko Uehara, Chinori Kurata ········· 2666 Molecular Cardiology 189. Aldosterone Signaling Associates With p300/GATA4 Transcriptional Pathway During the Hypertrophic Response of Cardiomyocytes Yoshinori Yoshida, Tatsuya Morimoto, Tomohide Takaya, Teruhisa Kawamura, Yoichi Sunagawa, Hiromichi Wada, Masatoshi Fujita, Akira Shimatsu, Toru Kita, Koji Hasegawa ········· 156 190. Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein Hajime Fujimoto, Hisae Kobayashi, Minoru Ohno ········· 353 191. Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese Yumiko Hiura, Yasuharu Tabara, Yoshihiro Kokubo, Tomonori Okamura, Yoichi Goto, Hiroshi Nonogi, Tetsuro Miki, Hitonobu Tomoike, Naoharu Iwai ········· 518 192. Sodium Valproate, a Histone Deacetylase Inhibitor, but Not Captopril, Prevents Right Ventricular Hypertrophy in Rats Young Kuk Cho, Gwang Hyeon Eom, Hae Jin Kee, Hyung-Seok Kim, Woo-Yeon Choi, Kwang-Il Nam, Jae Sook Ma, Hyun Kook ········· 760 193. Evaluation of Pharmacogenetic Algorithm for Warfarin Dose Requirements in Japanese Patients Fumihiko Takeuchi, Mitsuo Kashida, Osamu Okazaki, Yuriko Tanaka, Shoji Fukuda, Toshitaka Kashima, Shigeru Hosaka, Michiaki Hiroe, Sosuke Kimura, Norihiro Kato ········· 977 194. IL-10 Polymorphisms Are Associated With Coronary Artery Lesions in Acute Stage of Kawasaki Disease Ken-Pen Weng, Kai-Sheng Hsieh, Yu-Tung Hwang, Shih-Hui Huang, Tsung-Jen Lai, Yeong-Seng Yuh, Yu-Yi Hou, Chu-Chuan Lin, Shih-Chen Huang, Chian-Kai Chang, Ming-Wei Lin, Luo-Ping Ger ········· 983 195. Genetic Analysis of Young Adult Patients With Aortic Disease Not Fulfilling the Diagnostic Criteria for Marfan Syndrome Koichi Akutsu, Hiroko Morisaki, Toshiya Okajima, Tsuyoshi Yoshimuta, Yoshiaki Tsutsumi, Satoshi Takeshita, Hiroshi Nonogi, Hitoshi Ogino, Masahiro Higashi, Takayuki Morisaki ········· 990 196. Impact of Renin-Angiotensin System Polymorphisms on Development of Systolic Dysfunction in Hypertrophic Cardio- myopathy – Evidence From a Study of Genotyped Patients – Akira Funada, Tetsuo Konno, Noboru Fujino, Akihiko Muramoto, Kenshi Hayashi, Toshinari Tsubokawa, Kenji Sakata, Masa-aki Kawashiri, Yoshiyu Takeda, Hidekazu Ino, Masakazu Yamagishi ········· 2674

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Myocardial Disease 197. Beneficial Effects of Growth Hormone-Releasing Peptide on Myocardial Oxidative Stress and Left Ventricular Dysfunc- tion in Dilated Cardiomyopathic Hamsters Yosuke Kato, Mitsunori Iwase, Sahoko Ichihara, Hiroaki Kanazawa, Katsunori Hashimoto, Akiko Noda, Kohzo Nagata, Yasuo Koike, Mitsuhiro Yokota ········· 163 198. Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin Is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis Limin Ding, Haruo Hanawa, Yoshimi Ota, Go Hasegawa, Kazuhisa Hao, Fuyuki Asami, Ritsuo Watanabe, Tsuyoshi Yoshida, Ken Toba, Kaori Yoshida, Minako Ogura, Makoto Kodama, Yoshifusa Aizawa ········· 523 199. Significance of Maximal and Regional Left Ventricular Wall Thickness in Association With Arrhythmic Events in Patients With Hypertrophic Cardiomyopathy Valentina O. Puntmann, Yee Guan Yap, William McKenna, A. John Camm ········· 531 200. Long-Term Clinical Course of Patients With Isolated Myocardial Bridge Sung-Soo Kim, Myung Ho Jeong, Hyun Kuk Kim, Min Chul Kim, Kyung Hun Cho, Min Goo Lee, Jum Suk Ko, Keun Ho Park, Doo Sun Sim, Nam Sik Yoon, Hyun Ju Yoon, Hyung Wook Park, Ju Han Kim, Young Joon Hong, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang ········· 538 201. Cardioprotective Effect of Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide on Doxorubicin-Induced Cardiomyopathy in Mice Hiroyoshi Mori, Tomoya Nakamachi, Hirokazu Ohtaki, Sachiko Yofu, Atsushi Sato, Kimi Endo, Yoshitaka Iso, Hiroshi Suzuki, Youichi Takeyama, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba, Seiji Shioda ········· 1183 202. Impact of Metalloproteinases on Left Ventricular Remodeling and Heart Failure Events in Patients With Hypertrophic Cardiomyopathy Hiroaki Kitaoka, Toru Kubo, Makoto Okawa, Kayo Hayato, Naohito Yamasaki, Yoshihisa Matsumura, Yoshinori L. Doi ········· 1191 203. T-Wave Alternans and Left Ventricular Wall Thickness in Predicting Arrhythmic Risk in Patients With Hypertrophic Cardiomyopathy Valentina Otja Puntmann, Yee Guan Yap, William McKenna, John Camm ········· 1197 204. Myocardial Deformation in Acute Myocarditis With Normal Left Ventricular Wall Motion – A Cardiac Magnetic Reso- nance and 2-Dimensional Strain Echocardiographic Study – Gianluca Di Bella, Michele Gaeta, Alessandro Pingitore, Giuseppe Oreto, Concetta Zito, Fabio Minutoli, Carmelo Anfuso, Giuseppe Dattilo, Annalisa Lamari, Sebastiano Coglitore, Scipione Carerj ········· 1205 205. Electrocardiography Characteristics of Isolated Non-Compaction of Ventricular Myocardium in Japanese Adult Patients Masaaki Shoji, Takeshi Yamashita, Tokuhisa Uejima, Kazuo Asada, Hiroaki Semba, Takayuki Otsuka, Koichi Sagara, Hitoshi Sawada, Mitsuaki Isobe, Tadanori Aizawa ········· 1431 206. A National Survey on Myocarditis Associated With the 2009 Influenza A (H1N1) Pandemic in Japan Akira Ukimura, Tohru Izumi, Akira Matsumori, Clinical Research Committee on Myocarditis Associated with the 2009 Influenza A (H1N1) Pandemic in Japan organized by the Japanese Circulation Society ········· 2193 207. Inhibition of Contractile Activity During Postconditioning Enhances Cardioprotection by Restoring Sarcolemmal Dys- trophin Through Phosphatidylinositol 3-Kinase Akira Moriguchi, Hajime Otani, Kei Yoshioka, Takayuki Shimazu, Masanori Fujita, Toru Okazaki, Daisuke Sato, Shiori Kyoi, Toshiji Iwasaka ········· 2393 208. Cardiac Abnormalities in Primary Hyperoxaluria Farouk Mookadam, Travis Smith, Panupong Jiamsripong, Sherif E Moustafa, Carla G. Monico, John C. Lieske, Dawn S. Milliner ········· 2403 209. Spontaneous Development of Left Ventricular Hypertrophy and Diastolic Dysfunction in Mice Lacking All Nitric Oxide Synthases Kiyoko Shibata, Yasuko Yatera, Yumi Furuno, Ken Sabanai, Naoya Morisada, Sei Nakata, Tsuyoshi Morishita, Fumio Yamazaki, Akihide Tanimoto, Yasuyuki Sasaguri, Hiromi Tasaki, Yasuhide Nakashima, Hiroaki Shimokawa, Nobuyuki Yanagihara, Yutaka Otsuji, Masato Tsutsui ········· 2681 210. Restraint Stress Induces Connexin-43 Translocation via α-Adrenoceptors in Rat Heart Kana Unuma, Kaori Shintani-Ishida, Naoki Yahagi, Kensuke Tsushima, Tatsuo Shimosawa, Takashi Ueyama, Ken-ichi Yoshida ········· 2693 211. Abnormal Myocardial Energy-Production State in Mitochondrial Cardiomyopathy and Acute Response to L-Arginine Infusion – C-11 Acetate Kinetics Revealed by Positron Emission Tomography – Kenichiro Arakawa, Takashi Kudo, Masamichi Ikawa, Norihiro Morikawa, Yasuyuki Kawai, Ko Sahashi, Jong-Dae Lee, Masaru Kuriyama, Isamu Miyamori, Hidehiko Okazawa, Makoto Yoneda ········· 2702 212. Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restric- tive Silencing Factor Makoto Takano, Hideyuki Kinoshita, Takao Shioya, Masayuki Itoh, Kazuwa Nakao, Koichiro Kuwahara ········· 2712 Pediatric Cardiology and Adult Congenital Heart Disease 213. Antenatal Glucocorticoid Therapy Accelerates ATP Production With Creatine Kinase Increase in the Growth-Enhanced Fetal Rat Heart Masanori Mizuno, Yuko Takeba, Naoki Matsumoto, Yoshimitsu Tsuzuki, Kentaro Asoh, Masayuki Takagi, Shinichi Kobayashi, Hitoshi Yamamoto ········· 171

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214. Transcatheter Closure of Moderate-to-Large Patent Ductus Arteriosus in Infants Using Amplatzer Duct Occluder Jou-Kou Wang, Mei-Hwan Wu, Ming-Tai Lin, Shuenn-Nan Chiu, Chun-An Chen, Hsin-Hui Chiu ········· 361 215. IL-1B Polymorphism in Association With Initial Intravenous Immunoglobulin Treatment Failure in Taiwanese Chil- dren With Kawasaki Disease Ken-Pen Weng, Kai-Sheng Hsieh, Tsyr-Yuh Ho, Shih-Hui Huang, Chung-Ren Lai, Yi-Ten Chiu, Shih-Chen Huang, Chu-Chuan Lin, Yu-Tung Hwang, Luo-Ping Ger ········· 544 216. The Role of N-Terminal Pro-B-Type Natriuretic Peptide in the Diagnosis of Congestive Heart Failure in Children – Cor- relation With the Heart Failure Score and Comparison With B-Type Natriuretic Peptide – Masaya Sugimoto, Hiromi Manabe, Kouichi Nakau, Akiko Furuya, Kasumi Okushima, Hiroaki Fujiyasu, Fujio Kakuya, Kazutomo Goh, Kenji Fujieda, Hiroki Kajino ········· 998 217. Left Ventricular Outflow Tract Obstruction in Complete Transposition of the Great Arteries – Echocardiography Criteria for Surgical Strategies – Kun-Lang Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-An Chen, En-Ting Wu, Sheunn-Nan Chiu, Mei-Hwan Wu ········· 1214 218. Atherosclerosis in Patients With Cyanotic Congenital Heart Disease Mariëlle GJ Duffels, Karlijn M Mulder, Mieke D Trip, Erik de Groot, Johan Gort, Arie PJ van Dijk, Elke S Hoendermis, Luciano Daliento, Aeiko H Zwinderman, Rolf MF Berger, Barbara JM Mulder ········· 1436 219. Fetal and Neonatal Development of Ca2+ Transients and Functional Sarcoplasmic Reticulum in Beating Mouse Hearts Yoichi Kawamura, Takahiro Ishiwata, Mari Takizawa, Hideyuki Ishida, Yuh Asano, Shigeaki Nonoyama ········· 1442 220. Cut-Offs for Screening Prolonged QT Intervals From Fridericia’s Formula in Children and Adolescents Daisuke Hazeki, Masao Yoshinaga, Hideto Takahashi, Yuji Tanaka, Yasue Haraguchi, Mayumi Abe, Masami Koga, Toshiro Fukushige, Masami Nagashima ········· 1663 221. Matrix Metalloproteinase-9 in Vascular Lesions and Endothelial Regulation in Kawasaki Disease Koichi Sakata, Kenji Hamaoka, Seiichiro Ozawa, Ayumi Niboshi, Tomoyo Yahata, Maiko Fujii, Akiko Hamaoka, Kentarou Toiyama, Masashi Nishida, Toshiyuki Itoi ········· 1670 222. Stenting in Congenital Heart Disease – Medium- and Long-Term Outcomes From the JPIC Stent Survey – Hideshi Tomita, Toshio Nakanishi, Kenji Hamaoka, Toshiki Kobayashi, Yasuo Ono ········· 1676 223. Clinical Spectrum and Prognostic Factors of Pediatric Ventricular Tachycardia Mi-Kyoung Song, Jae-Suk Baek, Bo-Sang Kwon, Gi-Beom Kim, Eun-Jung Bae, Chung-Il Noh, Jung-Yun Choi ········· 1951 224. Reduced ACTC1 Expression Might Play a Role in the Onset of Congenital Heart Disease by Inducing Cardiomyocyte Apoptosis Hong-Kun Jiang, Guang-Rong Qiu, Jesse Li-Ling, Na Xin, Kai-Lai Sun ········· 2410 225. Tracking Serum Lipid Levels and the Association of Cholesterol Concentrations, Blood Pressure and Cigarette Smoking With Carotid Artery Intima – Media Thickness in Young Adults Born Small for Gestational Age Maria Salonen, Sirpa Tenhola, Tomi Laitinen, Tiina Lyyra-Laitinen, Jarkko Romppanen, Jarmo Jääskeläinen, Raimo Voutilainen ········· 2419 226. Clinical Characteristics of Patients With Kawasaki Disease and Levels of Peripheral Endothelial Progenitor Cells and Blood Monocyte Subpopulations Akio Kuroi, Toshio Imanishi, Hiroyuki Suzuki, Hideyuki Ikejima, Hiroto Tsujioka, Norishige Yoshikawa, Takashi Akasaka ········· 2720 227. Cytokine Genetic Polymorphisms and Susceptibility to Kawasaki Disease in Taiwanese Children Ken-Pen Weng, Tsyr-Yuh Ho, Ya-Hui Chiao, Jiin-Tsuey Cheng, Kai-Sheng Hsieh, Shih-Hui Huang, Shan-F Ou, Kai- His Liu, Ching-Ju Hsu, Pei-Jung Lu, Michael Hsiao, Luo-Ping Ger ········· 2726 Peripheral Vascular Disease 228. Cilostazol Increases Tissue Blood Flow in Contracting Rabbit Gastrocnemius Muscle Miranda Fong, Masuhiro Yoshitake, Junichi Kambayashi, Yongge Liu ········· 181 229. Patient-Based Outcomes Using the Walking Impairment Questionnaire for Patients With Peripheral Arterial Occlusive Disease Treated With Lipo-PGE1 Hiroshi Matsuo, Hiroshi Shigematsu ········· 365 230. Preventive Effects of Eicosapentaenoic Acid on Coronary Artery Disease in Patients With Peripheral Artery Disease – Subanalysis of the JELIS Trial – Yuichi Ishikawa, Mitsuhiro Yokoyama, Yasushi Saito, Masunori Matsuzaki, Hideki Origasa, Shinichi Oikawa, Jun Sasaki, Hitoshi Hishida, Hiroshige Itakura, Toru Kita, Akira Kitabatake, Noriaki Nakaya, Toshiie Sakata, Kazuyuki Shimada, Kunio Shirato, Yuji Matsuzawa for the JELIS Investigators, Japan ········· 1451 231. Classification of Corkscrew Collaterals in Thromboangiitis Obliterans (Buerger’s Disease) – Relationship Between Corkscrew Type and Prevalence of Ischemic Ulcers – Yuichi Fujii, Junko Soga, Shuji Nakamura, Takayuki Hidaka, Takaki Hata, Naomi Idei, Noritaka Fujimura, Kenji Nishioka, Kazuaki Chayama, Yasuki Kihara, Yukihito Higashi ········· 1684 232. Long-Term Clinical Outcome After Endovascular Treatment in Patients With Intermittent Claudication due to Iliofemoral Artery Disease Yoshimitsu Soga, Hiroyoshi Yokoi, Tomoko Urakawa, Atsushi Tosaka, Masashi Iwabuchi, Masakiyo Nobuyoshi ········· 1689 233. Determinants of Procedural Success and Patency Following Subintimal Angioplasty in Patients With TASC C and D Femoropopliteal Arterial Disease Seung Ju Kim, Weon Kim, Jong Bum Kim, Myung Ju Hong, Won Yu Kang, Sun Ho Hwang, Wan Kim ········· 1959

Circulation Journal Vol.74, December 2010 xx Contents of Volume 74, 2010

234. Characteristics of Revascularization Treatment for Arteriosclerosis Obliterans in Patients With and Without Hemodialysis Junichi Hoshino, Yo Fujimoto, Yoshihiro Naruse, Eiko Hasegawa, Tatsuya Suwabe, Naoki Sawa, Fumi Takemoto, Sugao Ishiwata, Minoru Ohno, Yoshifumi Ubara, Kunihiro Yamagata, Kenmei Takaichi ········· 2426 Preventive Medicine 235. A Randomized Controlled Open Comparative Trial of Varenicline vs Nicotine Patch in Adult Smokers – Efficacy, Safety and Withdrawal Symptoms (The VN-SEESAW Study) – Hitomi Tsukahara, Keita Noda, Keijiro Saku ········· 771 236. Standard-Dose Statin Therapy Provides Incremental Clinical Benefits in Normocholesterolemic Diabetic Patients Sunao Kojima, Tomohiro Sakamoto, Hisao Ogawa, Akira Kitagawa, Kunihiko Matsui, Hideki Shimomura, Kazuo Kimura, Yasuhiro Ogata, Naritsugu Sakaino on behalf of the Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors (MUSASHI) investigators ········· 779 237. Lifestyle Modification in Metabolic Syndrome and Associated Changes in Plasma Amino Acid Profiles Mitsumasa Kamaura, Kiyoko Nishijima, Mitsuo Takahashi, Toshihiko Ando, Shunsaku Mizushima, Osamu Tochikubo ········· 2434 Pulmonary Circulation 238. Autoimmune Thyroid Disease in Children and Adolescents With Idiopathic Pulmonary Arterial Hypertension Mari Satoh, Keiko Aso, Tomotaka Nakayama, Kazuyuki Naoi, Satoshi Ikehara, Yumiko Uchino, Hiromitsu Shimada, Shinichi Takatsuki, Hiroyuki Matsuura, Tsutomu Saji ········· 371 239. Meta-Analysis of Randomized Controlled Trials on Treatment of Pulmonary Arterial Hypertension Bing He, Fengwen Zhang, Xueying Li, Chaoshu Tang, Guosheng Lin, Junbao Du, Hongfang Jin ········· 1458 240. Effect of All-Trans-Retinoic Acid on the Development of Chronic Hypoxia-Induced Pulmonary Hypertension Erquan Zhang, Baohua Jiang, Ayumu Yokochi, Junko Maruyama, Yoshihide Mitani, Ning Ma, Kazuo Maruyama ········· 1696 241. Identification of New Prognostic Factors of Pulmonary Hypertension Yutaka Miura, Yoshihiro Fukumoto, Koichiro Sugimura, Minako Oikawa, Makoto Nakano, Shunsuke Tatebe, Saori Miyamichi, Kimio Satoh, Hiroaki Shimokawa ········· 1965 242. Marked Hemodynamic Improvements by High-Dose Epoprostenol Therapy in Patients With Idiopathic Pulmonary Arte- rial Hypertension Satoshi Akagi, Kazufumi Nakamura, Katsumasa Miyaji, Aiko Ogawa, Kengo Fukushima Kusano, Hiroshi Ito, Hiromi Matsubara ········· 2200 Regenerative Medicine 243. Ex-Vivo Expanded Umbilical Cord Blood Stem Cells Retain Capacity for Myocardial Regeneration Bernhard Schlechta, Dominik Wiedemann, Clemens Kittinger, Anita Jandrositz, Nikolaos E. Bonaros, Johannes C. Huber, Karl-Heinz Preisegger, Alfred A. Kocher ········· 188 244. Evidence for the Therapeutic Potential of Ex Vivo Expanded Human Endothelial Progenitor Cells Using Autologous Serum Takanori Shumiya, Rei Shibata, Yuuki Shimizu, Masakazu Ishii, Ryuji Kubota, Satoshi Shintani, Toyoaki Murohara ········· 1006 245. Tongue Muscle-Derived Stem Cells Express Connexin 43 and Improve Cardiac Remodeling and Survival After Myocardial Infarction in Mice Masaki Shibuya, Toshiro Miura, Yasuhiro Fukagawa, Shintaro Akashi, Takamasa Oda, Shuji Kawamura, Yasuhiro Ikeda, Masunori Matsuzaki ········· 1219 Renal Disease 246. Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients Arihiro Kiyosue, Yasunobu Hirata, Jiro Ando, Hideo Fujita, Toshihiro Morita, Masao Takahashi, Daisuke Nagata, Takahide Kohro, Yasushi Imai, Ryozo Nagai ········· 786 247. Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population Masafumi Sakuma, Motoyuki Nakamura, Fumitaka Tanaka, Toshiyuki Onoda, Kazuyoshi Itai, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Yuki Yoshida, Kazuko Kawamura, Shinji Makita, Akira Okayama ········· 792 248. A Systolic Parameter Defined as the Ratio of Brachial Pre-Ejection Period to Brachial Ejection Time Predicts Cardiovascular Events in Patients With Chronic Kidney Disease Szu-Chia Chen, Jer-Ming Chang, Jer-Chia Tsai, Tsung-Hsien Lin, Po-Chao Hsu, Ho-Ming Su, Wen-Chol Voon, Shang-Jyh Hwang, Hung-Chun Chen ········· 2206 249. Plasma Cystatin C Concentration Reflects the Severity of Coronary Artery Disease in Patients Without Chronic Kidney Disease Arihiro Kiyosue, Yasunobu Hirata, Jiro Ando, Hideo Fujita, Toshihiro Morita, Masao Takahashi, Daisuke Nagata, Takahide Kohro, Yasushi Imai, Ryozo Nagai ········· 2441 250. Association Between Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Maintenance Hemodialysis Patients – Comparison With B-Type Natriuretic Peptide and Cardiac Troponin T – Kazuaki Negishi, Mitsuru Kobayashi, Izuru Ochiai, Yuji Yamazaki, Hisashi Hasegawa, Takeyoshi Yamashita, Takehisa Shimizu, Shu Kasama, Masahiko Kurabayashi ········· 2734 Valvular Heart Disease 251. Long-Term Prognosis of Isolated Significant Tricuspid Regurgitation Jeong-Woo Lee, Jong-Min Song, Jong Pil Park, Jae Won Lee, Duk-Hyun Kang, Jae-Kwan Song ········· 375

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Vascular Medicine 252. Pitavastatin, an HMG-CoA Reductase Inhibitor, Ameliorates Endothelial Function in Chronic Smokers Osamu Yoshida, Takahisa Kondo, Yasuko Kureishi-Bando, Tomonori Sugiura, Kengo Maeda, Kenji Okumura, Toyoaki Murohara ········· 195 253. Effect of Adiponectin Overexpression on Stability of Preexisting Plaques by Inducing Prolyl-4-Hydroxylase Expression Li Li, Xiao-Jun Cai, Min Feng, Yuan-Yuan Rong, Yun Zhang, Mei Zhang ········· 552 254. Metabolic Syndrome and Carotid Artery Parameter in Koreans Aged 50 Years and Older Young-Hoon Lee, Min-Ho Shin, Sun-Seog Kweon, Jung-Ae Rhee, So-Yeon Ryu, Hye-Ran Ahn, Jin-Su Choi ········· 560 255. Calcium Channel Blockers Differentially Modulate Cytokine Production by Peripheral Blood Mononuclear Cells Akira Matsumori, Ryosuke Nishio, Yoshisuke Nose ········· 567 256. Upregulation of Monocyte Tissue Factor Activity Is Significantly Associated With Low-Grade Chronic Inflammation and Insulin Resistance in Patients With Metabolic Syndrome Akihiro Nakagomi, Mihoko Sasaki, Youhei Ishikawa, Masako Morikawa, Toshiyuki Shibui, Yoshiki Kusama, Hirotsugu Atarashi, Kyoichi Mizuno ········· 572 257. Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers Jun-ichi Oyama, Toyoki Maeda, Kazuya Kouzuma, Ryuji Ochiai, Ichiro Tokimitsu, Yoshihiro Higuchi, Masahiro Sugano, Naoki Makino ········· 578 258. Combination Therapy With Olmesartan and Azelnidipine Improves EDHF-Mediated Responses in Diabetic Apolipopro- tein E-Deficient Mice Maki Hosoya, Junko Ohashi, Ayuko Sawada, Aya Takaki, Hiroaki Shimokawa ········· 798 259. Effects of Removing the Adventitia on the Mechanical Properties of Ovine Femoral Arteries In Vivo and In Vitro Edmundo Cabrera Fischer, Daniel Bia Santana, Yanina Zócalo, Juan Camus, Eduardo de Forteza, Ricardo Armentano ········· 1014 260. Characterization of the Antiplatelet Effect of Aspirin at Enrollment and After 2-Year Follow-up in a Real Clinical Setting in Japan Tomoyuki Ikeda, Ryoji Taniguchi, Shin Watanabe, Mitsunori Kawato, Hirokazu Kondo, Ryutaro Shirakawa, Keiichiro Yamane, Masanao Toma, Toshihiro Tamura, Kanako Takahashi, Haruyo Watanabe, Yuka Yoshikawa, Arata Tabuchi, Toru Kita, Takeshi Kimura, Hisanori Horiuchi ········· 1227 261. Antiplatelet Therapy for the Prevention of Arterial Ischemic Events in Takayasu Arteritis Alexandre W. S. de Souza, Natália P. Machado, Vanessa M. Pereira, Anne E. D. Arraes, Edgard T. Reis Neto, Henrique A. Mariz, Emilia Inoue Sato ········· 1236 262. Dipyridamole Suppresses High Glucose-Induced Osteopontin Secretion and mRNA Expression in Rat Aortic Smooth Muscle Cells Ming-Song Hsieh, Wen-Bin Zhong, Shu-Chuan Yu, John Yi-Chung Lin, Wei-Ming Chi, Horng-Mo Lee ·········· 1242 263. Waveform of Ophthalmic Artery Doppler Flow Predicts the Severity of Systemic Atherosclerosis Hidetomo Maruyoshi, Sunao Kojima, Shinobu Kojima, Yasuhiro Nagayoshi, Yoko Horibata, Koichi Kaikita, Seigo Sugiyama, Hisao Ogawa ········· 1251 264. Assessment of Mechanical Properties of Common Carotid Artery in Takayasu’s Arteritis Using Velocity Vector Imaging In Jeong Cho, Chi Young Shim, Woo-In Yang, Sung-Ai Kim, Hyuk-Jae Chang, Yangsoo Jang, Namsik Chung, Jong-Won Ha ········· 1465 265. Single Administration of α-Glucosidase Inhibitors on Endothelial Function and Incretin Secretion in Diabetic Patients With Coronary Artery Disease – Juntendo University Trial: Effects of Miglitol on Endothelial Vascular Reactivity in Type 2 Diabetic Patients With Coronary Heart Disease (J-MACH) – Makoto Hiki, Kazunori Shimada, Takashi Kiyanagi, Kosuke Fukao, Kuniaki Hirose, Hiromichi Ohsaka, Yoshifumi Fukushima, Atsumi Kume, Rie Matsumori, Katsuhiko Sumiyoshi, Tetsuro Miyazaki, Hirotoshi Ohmura, Takeshi Kurata, Takashi Miida, Hiroyuki Daida ········· 1471 266. Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice Juha Ketonen, Jin Shi, Essi Martonen, Eero Mervaala ········· 1479 267. Reproducibility of High-Sensitivity C-Reactive Protein as an Inflammatory Component of Metabolic Syndrome in Japanese Eiji Oda, Ryu Kawai ········· 1488 268. Synergistic Effects of Calcium-Channel and Angiotensin-Receptor Blockers on Endothelial Function and Inflammatory Responses in a Porcine Drug-Eluting Stent Model Naozumi Kubota, Katsumi Miyauchi, Takatoshi Kasai, Takafumi Iesaki, Kan Kajimoto, Katsuhiko Sumiyoshi, Tomotaka Dohi, Hiroyuki Daida ········· 1704 269. Coadministration of Carvedilol Attenuates Nitrate Tolerance by Preventing Cytochrome P450 Depletion Atsushi Nakahira, Yukiko Minamiyama, Shigekazu Takemura, Hidekazu Hirai, Yasuyuki Sasaki, Shigeru Okada, Yoshihiko Funae, Shigefumi Suehiro ········· 1711 270. Soluble Fms-Like Tyrosine Kinase-1 and the Progression of Carotid Intima-Media Thickness – 24-Month Follow-up Study – Sanghoon Shin, Sang-Hak Lee, Sungha Park, Seok-Min Kang, Namsik Chung, Won-Heum Shim, Seung-Yun Cho, Ichiro Manabe, Yangsoo Jang ········· 2211 271. Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-κB Pathway Natsumi Masai, Junko Tatebe, Gen Yoshino, Toshisuke Morita ········· 2216 272. Gender Differences in the ST Segment – Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone –

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Kaori Ezaki, Mikiko Nakagawa, Yayoi Taniguchi, Yasuko Nagano, Yasushi Teshima, Kunio Yufu, Naohiko Takahashi, Takeo Nomura, Fuminori Satoh, Hiromitsu Mimata, Tetsunori Saikawa ········· 2448

Rapid Communications

1. Double Transgenic Mice Crossed GFP-LC3 Transgenic Mice With αMyHC-mCherry-LC3 Transgenic Mice Are a New and Useful Tool to Examine the Role of Autophagy in the Heart Mai Terada, Kiyoshi Nobori, Yoshiko Munehisa, Manabu Kakizaki, Takayoshi Ohba, Yoichiro Takahashi, Takashi Koyama, Yutaka Terata, Masaru Ishida, Kenji Iino, Toshimitsu Kosaka, Hiroyuki Watanabe, Hitoshi Hasegawa, Hiroshi Ito ········· 203 2. Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa ········· 589 3. Vascular Response to Overlapping Everolimus-Eluting Stents – Comparison With Paclitaxel-Eluting Stents – Hiromasa Otake, Yasuhiro Honda, Masao Yamasaki, Ichizo Tsujino, Takao Shimohama, Ryota Sakurai, Takao Hasegawa, Katsuhisa Waseda, Junya Ako, Peter J. Fitzgerald ········· 1023 4. Intriguing Peri-Strut Low-Intensity Area Detected by Optical Coherence Tomography After Coronary Stent Deployment Tomohiko Teramoto, Fumiaki Ikeno, Hiromasa Otake, Jennifer K. Lyons, Heleen M. M. van Beusekom, William F. Fearon, Alan C. Yeung ········· 1257 5. A Novel Program to Accurately Quantify Infarction Volume by 99mTc MIBI SPECT, and Its Application for Re-Analyzing the Effect of Erythropoietin Administration in Patients With Acute Myocardial Infarction – A Randomized Controlled Pilot Trial of the EPO/AMI-I Study – Norihiko Yoshimura, Ken Toba, Takuya Ozawa, Yoshifusa Aizawa, Tetsuo Hosoya ········· 2741

Controversies in Cardiovascular Medicine

LDL-Cholesterol: The Lower, the Better; Is It True for Asians? 1. (Pro) Clinical Significance of Intensive Lipid-Lowering Therapy Using Statins in Patients With Coronary Artery Disease Katsumi Miyauchi, Hiroyuki Daida ········· 1718 2. (Con) “Just Make It Lower” Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients Tomohiro Sakamoto, Hisao Ogawa ········· 1731 Is Catheter Ablation Established as a Treatment Option of Atrial Fibrillation? 3. (Pro) Catheter Ablation Is Established as a Treatment Option for Atrial Fibrillation Atsushi Takahashi ········· 1972 4. (Con) Is Catheter Ablation a Mature Fruit for Treatment of Atrial Fibrillation? Takeshi Yamashita ········· 1978 Should Drug-Eluting Stents Be Indicated for Patients With Acute Coronary Syndrome? 5. (Pro) What Is the Effectiveness of Drug-Eluting Stents in the Treatment of ST-Elevation Myocardial Infarction? Yoshihisa Nakagawa ········· 2225 6. (Con) Drug-Eluting Stents Are Not Indicated for Patients With Acute Coronary Syndrome Katsumi Inoue ········· 2232 Do Patients With Drug-Induced Brugada Type ECG Have Poor Prognosis? 7. (Pro) Is This a Philosophic Issue? Akihiko Shimizu ········· 2455 8. (Con) Low Risk for Arrhythmic Events in Asymptomatic Patients With Drug-Induced Type 1 ECG Mitsuhiro Nishizaki, Harumizu Sakurada, Noriyoshi Yamawake, Akiko Ueda-Tatsumoto, Masayasu Hiraoka ·········· 2464 Therapeutic Strategies for 3-Vessel Coronary Artery Disease: OPCAB vs PCI 9. (PCI-Side) Is Angioplasty Able to Become the Gold Standard of Treatment Beyond Bypass Surgery for Patients With Multivessel Coronary Artery Disease? Tadateru Takayama, Takafumi Hiro, Atsushi Hirayama ········· 2744 10. (OPCAB-Side) Off-Pump Coronary Artery Bypass vs Percutaneous Coronary Intervention Masaru Nishimi, Tadashi Tashiro ········· 2750

Images in Cardiovascular Medicine

1. Unique Myocardial Fibrosis Pattern by Late Gadolinium Enhanced Magnetic Resonance Imaging in a Patient With Iso- lated Noncompaction of the Ventricular Myocardium Tairo Kurita, Koji Matsuoka, Kyoko Hoshida, Shiro Nakamori, Yasutaka Ichikawa, Takashi Tanigawa, Katsuya Onishi, Tomoaki Nakamura, Hajime Sakuma, Masaaki Ito ········· 381

Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 xxiii

2. Vegetation With Ventricular Septal Defect Detected by Cardiac Magnetic Resonance Imaging Tairo Kurita, Masaki Tanabe, Kakuya Kitagawa, Katsuya Onishi, Hideto Shimpo, Hajime Sakuma, Masaaki Ito ········· 592 3. Three-Dimensional Transesophageal Echocardiographic Recognition of Mobile Mass Protruding Into the Left Main Cor- onary Orifice in a Patient With Aortic Stenosis Mai Iwataki, Masaaki Takeuchi, Hidetoshi Yoshitani, Nobuhiko Haruki, Kyoko Kaku, Yutaka Otsuji ········· 807 4. Assessment of a Coronary Artery Fistula Using Coronary Pressure Wire Olivier Muller, Sofie Verstreken, Marc Vanderheyden ········· 1026 5. High-Output Cardiomyopathy Regression Following Percutaneous Closure of Left Internal Mammary and Subclavian to Pulmonary Artery Fistulae Elias Adreanides, Gregory Giamouzis, Gregory Pavlides ········· 1260 6. Cardiac Magnetic Resonance Imaging and 2-Dimensional Speckle Tracking Echocardiography in Secondary Cardiac Amyloidosis Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Takao Shoichiro, Masafumi Harada, Noriko Kagawa, Eiji Kudo, Masataka Sata ········· 1494 7. Optical Coherence Tomography as a Novel Diagnostic Tool for Distal Type Chronic Thromboembolic Pulmonary Hyper- tension Shunsuke Tatebe, Yoshihiro Fukumoto, Koichiro Sugimura, Makoto Nakano, Saori Miyamichi, Kimio Satoh, Minako Oikawa, Hiroaki Shimokawa ········· 1742 8. Reversible Pulmonary Hypertension, Lactic Acidosis, and Rapidly Evolving Multiple Organ Failure as Manifestations of Shoshin Beriberi Hiro Yamasaki, Hiroshi Tada, Satoru Kawano, Kazutaka Aonuma ········· 1983 9. Left Ventricular Pseudo-False Aneurysm Detected With ECG-Gated Multidetector Computed Tomography and Cardiac Magnetic Resonance Imaging Hayato Ohtani, Hideki Katoh, Takeji Saitoh, Katsunori Shiraki, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh, Naoki Washiyama, Hitoshi Terada, Katsuji Yamashita, Hideharu Hayashi ········· 1986 10. Silent Myocardial Ischemia in Adult Bland–White–Garland Syndrome Hiromasa Hasegawa, Takanori Arimoto, Tadateru Iwayama, Daisuke Kutsuzawa, Satoshi Nishiyama, Joji Nitobe, Tetsu Watanabe, Mitsuaki Sadahiro, Isao Kubota ········· 2239 11. Dual-Source Computed Tomography for Visualization of the Abnormal Motion of the Aortic Cusp After Re-Replacement of the Mitral Valve Fumiaki Shikata, Mitsugi Nagashima, Kanji Kawachi, Teruhito Kido, Kouki Watanabe, Masahiro Ryugo, Hiroshi Imagawa, Teruhito Mochizuki ········· 2241 12. Unusual Macro-Reentrant Atrial Flutter Because of Extensive Atrial Myocardial Damage in a Seemingly Structurally Normal Heart Takanori Arimoto, Hiroshi Tada, Hiro Yamasaki, Miyako Igarashi, Yukio Sekiguchi, Kazutaka Aonuma ········· 2474 13. Second Left Ventricular Aneurysm Newly Developed in a Patient With Untreated Cardiac Sarcoidosis Takahiro Sato, Hideaki Kanzaki, Yoshio Ishida, Makoto Amaki, Takahiro Ohara, Takuya Hasegawa, Kazuhiko Hashimura, Satoshi Nakatani, Naoaki Yamada, Yoshihiko Ikeda, Hatsue Ueda-Ishibashi, Masafumi Kitakaze ·········· 2477 14. MRI Is Useful for Diagnosis of H1N1 Fulminant Myocarditis Ichiro Takeuchi, Ryuta Imaki, Takayuki Inomata, Kazui Soma, Tohru Izumi ········· 2758

JCS Guidelines

1. Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) – Digest Version – JCS Joint Working Group ········· 1745 2. Guidelines for Diagnosis and Management of Cardiovascular Sequelae in Kawasaki Disease (JCS 2008) – Digest Version – JCS Joint Working Group ········· 1989 3. Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) – Digest Version – JCS Joint Working Group ········· 2479 4. Guidelines for Radiation Safety in Interventional Cardiology (JCS 2006) – Digest Version – JCS Joint Working Group ········· 2760

Letters to the Editor

1. Optimal Cutoff Points of Waist Circumference for the Criteria of Abdominal Obesity: Comparison With the Criteria of the International Diabetes Federation Eiji Oda ········· 207 2. Optimal Cutoff Points of Waist Circumference for the Criteria of Abdominal Obesity: Comparison With the Criteria of the International Diabetes Federation – Reply – Inkyung Baik ········· 208 3. Validity of Using Body Mass Index as a Surrogate Measure of Abdominal Obesity

Circulation Journal Vol.74, December 2010 xxiv Contents of Volume 74, 2010

Toshiaki Otsuka, Tomoyuki Kawada ········· 383 4. Validity of Using Body Mass Index as a Surrogate Measure of Abdominal Obesity – Reply – Fujiko Irie ········· 384 5. Ambulatory ECG-Based T-Wave Alternans John E. Madias ········· 594 6. Ambulatory ECG-Based T-Wave Alternans: – Reply – Shingo Maeda, Mitsuhiro Nishizaki, Masayasu Hiraoka, Mitsuaki Isobe ········· 595 7. Invasive or Non-Iinvasive? That Is (Still) the Question Alessandro Desideri ········· 1028 8. Invasive or Non-Invasive? That Is (Still) the Question – Reply – Masahiro Yasutake, Teruo Takano ········· 1029 9. Whole Blood Passage Time: What Does It Mean? Kazuhiko Okamoto, Keita Odashiro, Toru Maruyama ········· 1497 10. Whole Blood Passage Time: What Does It Mean? – Reply – Takanori Yasu, Nahoko Ikeda ········· 1498 11. Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients Eiji Oda ········· 1763 12. Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients – Reply – Arihiro Kiyosue, Yasunobu Hirata ········· 1764 13. An Interplay Between Left Ventricular Wall Thickness and T-Wave Alternans in Patients With Hypertrophic Cardiomy- opathy in Predicting Ventricular Tachyarrythmic Events: Is T-Wave Amplitude Difference the Reason? John E. Madias ········· 1766 14. An Interplay Between Left Ventricular Wall Thickness and T-Wave Alternans in Patients With Hypertrophic Cardiomy- opathy in Predicting Ventricular Tachyarrythmic Events: Is T-Wave Amplitude Difference the Reason? – Reply – Valentina O. Puntmann ········· 1767 15. Drug-Eluting Stents vs Bypass Surgery for Multivessel Disease Hisato Takagi, Takuya Umemoto ········· 2021 16. Drug-Eluting Stents vs Bypass Surgery for Multivessel Disease – Reply – Yu Kataoka ········· 2023 17. Even Isolated Left Ventricular Hypertrabeculation May Indicate Multisystem Disease Josef Finsterer, Claudia Stöllberger ········· 2024 18. Even Isolated Left Ventricular Hypertrabeculation May Indicate Multisystem Disease – Reply – Masaaki Shoji ········· 2025 19. Drug-Eluting Stents vs Bypass Surgery for Unprotected Left Main Disease Hisato Takagi, Takuya Umemoto ········· 2244 20. Drug-Eluting Stents vs Bypass Surgery for Unprotected Left Main Disease – Reply – Tsuyoshi Shimizu, Minoru Ono ········· 2245 21. Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students Eiji Oda ········· 2246 22. Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students – Reply – Minoru Hongo ········· 2247 23. Waist-Height Ratio, Indicator of Central Obesity, Is Strongly Related to Waist Circumference but There Is Poor Addi- tional Information Regarding Waist Circumference Tomoyuki Kawada ········· 2501 24. Waist-Height Ratio, Indicator of Central Obesity, Is Strongly Related to Waist Circumference but There Is Poor Addi- tional Information Regarding Waist Circumference – Reply – Sung-Hee Park, Hyun-Young Park ········· 2502 25. Meta-Analysis of Randomized Controlled Trials on the Treatment of Pulmonary Arterial Hypertension Olalekan A. Uthman, Ismail Yahaya ········· 2503 26. Meta-Analysis of Randomized Controlled Trials on the Treatment of Pulmonary Arterial Hypertension – Reply – Fengwen Zhang, Junbao Du, Hongfang Jin, Xueying Li ········· 2504 27. Beneficial Effects of Eicosapentaenoic Acid in Coronary Heart Disease With Peripheral Vascular Diseases: But How and Why? Undurti N Das ········· 2786 28. Beneficial Effects of Eicosapentaenoic Acid in Coronary Heart Disease With Peripheral Vascular Diseases: But How and Why? – Reply – Yuichi Ishikawa ········· 2787 29. Effect of Preoperative Statin Therapy on Postoperative Atrial Fibrillation in Cardiac Surgery Hisato Takagi, Takuya Umemoto ········· 2788 30. Effect of Preoperative Statin Therapy on Postoperative Atrial Fibrillation in Cardiac Surgery – Reply – Qiang Ji, Yunqing Mei, Dewei Wusha ········· 2790

Circulation Journal Vol.74, December 2010