ii Contents of Volume 74, 2010 CONTENTS OF VOLUME 74, 2010 Message From the Editor-in-Chief 1. Circulation Journal – A Cloud Over the Hill – Hiroaki Shimokawa ········ 1 2. Editorial Statistics and Best Reviewers Awards for 2009 Hiroaki Shimokawa ········ 211 3. Circulation Journal Awards of the Year 2009 Hiroaki Shimokawa ········ 387 4. New Editorial Team of Circulation Journal Hiroaki Shimokawa ········ 1263 5. Message From the Editor-in-Chief Hiroaki Shimokawa ········ 1499 6. Message From the Editor-in-Chief Hiroaki Shimokawa ········ 1769 Reviews 1. Tissue Factor and Cardiovascular Disease – Quo Vadis? – Alexander Breitenstein, Felix C. Tanner, Thomas F. Lüscher ········ 3 2. Mechanisms of Myocardial Regeneration Toru Hosoda, Jan Kajstura, Annarosa Leri, Piero Anversa ········ 13 3. Three-Dimensional Electroanatomic Mapping Systems in Catheter Ablation of Atrial Fibrillation Li-Wei Lo, Shih-Ann Chen ········ 18 4. Non-Invasive Vascular Function Tests – Their Pathophysiological Background and Clinical Application – Hirofumi Tomiyama, Akira Yamashina ········ 24 5. Non-Invasive Assessment and Clinical Strategy of Stable Coronary Artery Disease by Magnetic Resonance Imaging, Multislice Computed Tomography and Myocardial Perfusion SPECT Naoya Matsumoto, Ken Nagao, Atsushi Hirayama, Yuichi Sato ········ 34 6. Inflammation in Atherosclerosis – Transition From Theory to Practice – Peter Libby, Yoshihisa Okamoto, Viviane Z. Rocha, Eduardo Folco ········ 213 7. The Initiation of the Heart Beat Peng-Sheng Chen, Boyoung Joung, Tetsuji Shinohara, Mithilesh Das, Zhenhui Chen, Shien-Fong Lin ········ 221 8. Coordination of Vasomotor Responses by the Endothelium Kim A. Dora ········ 226 9. Characteristics of Chronic Rejection in Heart Transplantation – Important Elements of Pathogenesis and Future Treatments – Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai ········ 233 10. Coronary Angioscopic Evaluation for Serial Changes of Luminal Appearance After Pharmacological and Catheter Inter- ventions Masamichi Takano, Kyoichi Mizuno ········ 240 11. Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction Xian-Liang Tang, D. Gregg Rokosh, Yiru Guo, Roberto Bolli ········ 390 12. Angiotensin-Converting Enzyme 2 (ACE2) in Disease Pathogenesis Yumiko Imai, Keiji Kuba, Takayo Ohto-Nakanishi, Josef M. Penninger ········ 405 13. Acute Coronary Syndrome – Insight From Angioscopy – Yasunori Ueda, Nobuyuki Ogasawara, Koushi Matsuo, Shinichi Hirotani, Kazunori Kashiwase, Akio Hirata, Mayu Nishio, Takayoshi Nemoto, Mitsuru Wada, Yuki Masumura, Toshikazu Kashiyama, Shouzou Konishi, Hiroyuki Nakanishi, Yusuke Kobayashi, Yasuhiro Akazawa, Kazuhisa Kodama ········ 411 14. Role of the SDF-1/CXCR4 System in Myocardial Infarction Masafumi Takahashi ········ 418 15. Basic Principles of Platelet Biology and Clinical Implications Dominick J. Angiolillo, Masafumi Ueno, Shinya Goto ········ 597 16. Potassium Channels and Neurovascular Coupling Kathryn M. Dunn, Mark T. Nelson ········ 608 17. Waon Therapy for Cardiovascular Disease – Innovative Therapy for the 21st Century – Masaaki Miyata, Chuwa Tei ········ 617 Circulation Journal Vol.74, December 2010 Contents of Volume 74, 2010 iii 18. The Future of Pharmacological Therapy for Heart Failure Yusuke Sata, Henry Krum ········ 809 19. Pleiotropic Effects of Statins – Basic Research and Clinical Perspectives – Qian Zhou, James K. Liao ········ 818 20. Oxidative Stress and Central Cardiovascular Regulation – Pathogenesis of Hypertension and Therapeutic Aspects – Yoshitaka Hirooka, Yoji Sagara, Takuya Kishi, Kenji Sunagawa ········ 827 21. Prostacyclin in Vascular Diseases – Recent Insights and Future Perspectives – Jun-ichi Kawabe, Fumitaka Ushikubi, Naoyuki Hasebe ········ 836 22. Current State of Surgical Myocardial Revascularization Frank W. Sellke, Louis M. Chu, William E. Cohn ········ 1031 23. What We Have Learned From the Family of Multicenter Automatic Defibrillator Implantation Trials Arthur J. Moss ········ 1038 24. Stromal Cell Biology – A Way to Understand the Evolution of Cardiovascular Diseases – Toshihiro Tsuruda, Takuroh Imamura, Kinta Hatakeyama, Yujiro Asada, Kazuo Kitamura ········ 1042 25. Electrophysiological Characteristics of Atrial Tachycardia After Pulmonary Vein Isolation of Atrial Fibrillation Kazuhiro Satomi ········ 1051 26. Novel Heart Failure Therapy Targeting Transcriptional Pathway in Cardiomyocytes by a Natural Compound, Curcumin Tatsuya Morimoto, Yoichi Sunagawa, Masatoshi Fujita, Koji Hasegawa ········ 1059 27. Sex and Gender Differences in Myocardial Hypertrophy and Heart Failure Vera Regitz-Zagrosek, Sabine Oertelt-Prigione, Ute Seeland, Roland Hetzer ········ 1265 28. Heart Failure, Chronic Kidney Disease, and Biomarkers – An Integrated Viewpoint – Yoshitaka Iwanaga, Shunichi Miyazaki ········ 1274 29. Coronary Collateral Growth and Its Therapeutic Application to Coronary Artery Disease Masatoshi Fujita, Shigetake Sasayama ········ 1283 30. Mechanisms of Vein Graft Adaptation to the Arterial Circulation – Insights Into the Neointimal Algorithm and Man- agement Strategies – Akihito Muto, Lynn Model, Kenneth Ziegler, Sammy D.D. Eghbalieh, Alan Dardik ········· 1501 31. Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis Hidehiko Hara, Robert S. Schwartz ········ 1513 32. Heparin Cofactor II Attenuates Vascular Remodeling in Humans and Mice Ken-ichi Aihara ········ 1518 33. ISAR – A Story of Trials With Impact on Practice – Stefanie Schulz, Julinda Mehilli, Albert Schömig, Adnan Kastrati ········ 1771 34. Cardiovascular Side-Effects of Modern Cancer Therapy Manabu Minami, Shigemi Matsumoto, Hisanori Horiuchi ········ 1779 35. Cardioprotection by Hormetic Responses to Aldehyde Motoaki Sano ········ 1787 36. Diet and Risk of Atrial Fibrillation – Epidemiologic and Clinical Evidence – Noelle N. Gronroos, Alvaro Alonso ········ 2029 37. Early Repolarization Syndrome – A New Electrical Disorder Associated With Sudden Cardiac Death – Shinsuke Miyazaki, Ashok J Shah, Michel Haïssaguerre ········ 2039 38. Macrophages, Oxysterols and Atherosclerosis Norihito Shibata, Christopher K. Glass ········ 2045 39. Cyclophilin A – Promising New Target in Cardiovascular Therapy – Kimio Satoh, Hiroaki Shimokawa, Bradford C. Berk ········ 2249 40. Aging and Arterial Stiffness Hae-Young Lee, Byung-Hee Oh ········ 2257 41. Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis Tomoyuki Yasuda, Tatsuro Ishida, Daniel J. Rader ········ 2263 42. Risk Stratification and Role of Implantable Defibrillators for Prevention of Sudden Death in Patients With Hypertrophic Cardiomyopathy Barry J. Maron ········ 2271 43. Heart Failure and the Lung Kirk Kee, Matthew T. Naughton ········ 2507 44. Cardiogenesis From Human Embryonic Stem Cells – Mechanisms and Applications – John L. Mignone, Kareen L. Kreutziger, Sharon Paige, Charles E. Murry ········ 2517 45. Role of Cellular Senescence in Lifestyle-Related Disease (2009 Sato Award) Tohru Minamino ········ 2527 Circulation Journal Vol.74, December 2010 iv Contents of Volume 74, 2010 Scientific Comments The 2010 ESC Guidelines for AF 1. The 2010 Update of the ESC Guidelines for the Management of Atrial Fibrillation – What the Changes Will Mean for Clinicians – Sébastien Knecht, Stephen B. Wilton, Michel Haïssaguerre ········ 2534 2. The 2010 Update of the ESC Guidelines for the Management of Atrial Fibrillation – Beyond the Rate or Rhythm Strategy Debate – Jeffrey WH Fung, Cheuk-Man Yu ········ 2538 3. Antithrombotic Therapy – ESC Guidelines vs JCS Guidelines – Hiroshi Inoue ········ 2542 Editorials 1. Noncontact Mapping – Utility and Limitations – Yoshifusa Aizawa ········ 41 2. Japan Expects Decrements in Both the Incidence and Mortality of Acute Myocardial Infarction in the Modern Era – Likely or Just a Dream? – Masanori Asakura, Tetsuo Minamino, Masafumi Kitakaze ········ 43 3. Role of Endostatin in Cardiovascular Remodeling Koji Maemura ········ 45 4. Antenatal Glucocorticoid Therapy for Fetal Heart Development Masashi Arai ········ 47 5. Novel In Vivo Tool to Evaluate Autophagic Activity in the Heart Osamu Yamaguchi, Kinya Otsu ········ 49 6. Inflammation and Atrial Fibrillation Nobuhisa Hagiwara ········ 246 7. Green Tea Consumption and Prevention of Coronary Artery Disease Shinichi Kuriyama ········ 248 8. Is Right Ventricular Dysfunction in Obstructive Sleep Apnea a Potential Screening Tool? Masaaki Uematsu ········ 250 9. Can an Intravascular Imaging Modality Detect Really Vulnerable Plaque? Tadateru Takayama ········ 252 10. Cardiovascular Disease and Chronic Obstructive Pulmonary Disease Makoto Sata ········ 254 11. Towards a Tailored Use of Eluted Drugs for Percutaneous Coronary Interventions Marco Zimarino, Benedetta Ruggieri, Raffaele De Caterina ········ 424 12. Multidisciplinary Approach to Severe Coronary Artery Disease Masami Ochi ········ 426 13. Controversies on Obesity and CKD Sadayoshi Ito ········ 428 14. The Entire Coronary Arterial System Rather Than Just the Culprit Lesion Should be Evaluated in Patients With Acute Coronary Syndrome Shichiro Abe, Teruo Inoue, Isao Taguchi ········ 430 15. Role of Adiponectin in Cardiovascular Protection Mamoru Nanasato, Toyoaki Murohara ········ 432 16. PCI vs CABG in Complicated Diabetic Patients – Do We Need More Data to Change the Practical Guideline? – Kee-Sik Kim ········ 622 17. Long-Term Circulatory