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Home , Rabies vaccine

United States Department of Agriculture (USDA) Approved Animal

Table 1. Rabies Vaccines Licensed and Marketed in the United States, 2016 Age at For use Route of Product Name Produced by Marketed by Dose primary Booster in vaccination* A) MONOVALENT (Inactivated) RAB RABVAC 1 Boehringer Boehringer 1 ml 3 months Annually IM or SC Ingelheim Ingelheim Vetmedica Cats 1 ml 3 months Annually IM or SC Vetmedica Inc Inc License No. 124 RABVAC 3 Boehringer Boehringer Dogs 1 ml 3 months 1 year later & triennially IM or SC Ingelheim Ingelheim Vetmedica Cats 1 ml 3 months 1 year later & triennially IM or SC Vetmedica Inc Inc Horses 2 ml 3 months Annually IM License No. 124 EQUIRAB with Merck Animal Merck Animal Health Horses 1 ml 4 months Annually IM Havlogen Health License No. 165A DEFENSOR 1 Zoetis Zoetis Dogs 1 ml 3 months Annually IM or SC License No. 190 Cats 1 ml 3 months Annually SC

DEFENSOR 3 Zoetis Zoetis Dogs 1 ml 3 months 1 year later & triennially IM or SC License No. 190 Cats 1 ml 3 months 1 year later & triennially SC Sheep 2 ml 3 months Annually IM Cattle 2 ml 3 months Annually IM NOBIVAC: 1- Zoetis Merck Animal Health Dogs 1 ml 3 months Annually IM or SC Rabies License No. 190 Cats 1 ml 3 months Annually SC

NOBIVAC: 3- Zoetis Merck Animal Health Dogs 1 ml 3 months 1 year later & triennially IM or SC Rabies and 3- License No. 190 Cats 1 ml 3 months 1 year later & triennially SC Rabies CA Sheep 2 ml 3 months Annually IM Cattle 2 ml 3 months Annually IM IMRAB 1 Merial, Inc Merial, Inc Dogs 1 ml 3 months Annually SC License No. 298 Cats 1 ml 3 months Annually SC

IMRAB 1 TF Merial, Inc Merial, Inc Dogs 1 ml 3 months Annually SC License No. 298 Cats 1 ml 3 months Annually SC IMRAB 3 Merial, Inc Merial, Inc Dogs 1 ml 3 months 1 year later & triennially IM or SC License No. 298 Cats 1 ml 3 months 1 year later & triennially IM or SC Sheep 2 ml 3 months 1 year later & triennially IM or SC Cattle 2 ml 3 months Annually IM or SC Horses 2 ml 3 months Annually IM or SC 1 ml 3 months Annually SC

IMRAB 3 TF Merial, Inc Merial, Inc Dogs 1 ml 3 months 1 year later & triennially IM or SC License No. 298 Cats 1 ml 3 months 1 year later & triennially IM or SC Ferrets 1 ml 3 months Annually SC

IMRAB Merial, Inc Merial, Inc Cattle 2 ml 3 months Annually IM or SC Large Animal License No. 298 Horses 2 ml 3 months Annually IM or SC Sheep 2 ml 3 months 1 year later & triennially IM or SC

*Minimum age (or older) and one month = 28 days N/A= Not applicable, IM= Intramuscularly, SC= Subcutaneously Information is provided by the manufacturers and USDA APHIS’s Center for Veterinary Biologics and is subject to change. Age at Route of Product Name Produced by Marketed by For use in Dose primary Booster vaccination inoculation vaccination* B) MONOVALENT (Rabies glycoprotein, live canary pox vector)

PUREVAX Merial, Inc Merial, Inc Cats 1 ml 3 months Annually SC Feline License No. 298 Rabies PUREVAX Merial, Inc Merial, Inc Cats 1 ml 3 months 1 year later & triennially SC Feline License No. 298 Rabies 3YR C) COMBINATION (Inactivated) Equine Merial, Inc Merial, Inc Horses 1 ml 3 months Annually IM POTOMAVAC + License No. 298 IMRAB

D) COMBINATION (Rabies glycoprotein, live canary pox vector)

PUREVAX Merial, Merial, Inc Cats 1ml 8 weeks Every 3 to 4 weeks until 3 SC Feline 3/ Incorporated months & annually Rabies License No. 298 3 months 3 to 4 weeks later & annually

PUREVAX Merial, Inc Merial, Inc Cats 1ml 8 weeks Every 3 to 4 weeks until 3 SC Feline 4/ License No. 298 months & annually Rabies 3 months 3 to 4 weeks later & annually

E) ORAL (Rabies glycoprotein, live vaccinia vector) - RESTRICTED TO USE IN STATE AND FEDERAL RABIES CONTROL PROGRAMS

RABORAL V- Merial, Inc Merial, Inc N/A N/A As determined by local Oral RG License No. 298 authorities *Minimum age (or older) and one month = 28 days N/A= Not applicable, IM= Intramuscularly, SC= Subcutaneously Information is provided by the vaccine manufacturers and USDA APHIS’s Center for Veterinary Biologics and is subject to change.

Rabies Vaccine Descriptions Based upon information provided on the vaccine labels and provided by the manufacturers, Table 2 lists descriptions of the licensed rabies vaccines in the U.S. by vaccine name, line, virus strain, adjuvant, inactivation method, and preservative.

Table 2. Rabies Vaccine Description Manufacturer Name Cell Line Virus Strain Adjuvant Inactivation Preservative Boehringer Rabvac 1, 3 Not Disclosed Not Disclosed Yes, ß-propriolactone Gentamicin Ingelheim Not Disclosed Vetmedica Inc Zoetis Defensor 1, 3 Baby Hamster PV-Paris/BHK/ Aluminum ß-propriolactone Thimerosal Kidney purify.paff3,svr hydroxide Gentamicin 289

Merck Animal Nobivac 1, 3 Baby Hamster Pasteur Yes Chemically Gentamicin Health Inc Kidney inactivated (Marketed by Merck, produced by Zoetis) Merck Animal EquiRab with Havlogen Not Disclosed Not Disclosed Havlogen® Not Disclosed Thimerosal, Health Inc Neomycin, Polymyxin B Merial Inc Imrab 1, 3 Murine Pasteur (PV-11) Aluminum Not Disclosed Gentamicin Imrab 1, 3 TF hydroxide Imrab Large Animal Equine POTOMAVAC + Imrab Purvax Feline Rabies ------Recombinant N/A N/A Gentamicin Purvax Feline Rabies 3YR canarypox vector Purevax 3/Rabies Purvax 4/Rabies Raboral V-RG ------Recombinant ------N/A ------vaccinia vector

Table 3. Rabies Vaccine Manufacturer Contact Information Manufacturer Phone Number Internet Address

Boehringer Ingelheim Vetmedica Inc 800–638–2226 www.bi-vetmedica.com

Merck Animal Health Inc 800–521–5767 www.merck-animal-health-usa.com

Merial Inc 888–637–4251 www.us.merial.com

Zoetis 800–366–5288 www.zoetis.com

Adverse Events: Adverse events should be reported to the vaccine manufacturer and to USDA, Animal and Plant Health Inspection Service, Center for Veterinary Biologics Telephone: 800-752-6255 E-mail: [email protected] Internet address: http://www.aphis.usda.gov/animalhealth/cvb_aer