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950 febrile attacks again developed on Oct. 10th and Nov. 9th THE THOMPSON YATES AND JOHNSTON and 14th, 1903, but there was no more fever until March, LABORATORIES REPORT.1 1904. On June 2nd, 1904, the last note on this patient was, ’’ For last few days patient has complained of lack THIS interesting publication includes the Reports of of appetite and loss of energy; the swellings on face and hands a has on the chest." the Expedition to the Congo, 1903-1904 persist; papular eruption appeared Trypanosomiasis The other case recorded is that of a captain of a steamer of the School of Medi- (Memoir XIIL), Liverpool Tropical on the Congo, aged 28 years. The inference gathered cine and Medical Parasitology, by Dr. J. Everett Dutton, from a study of this case is stated as follows : " It therefore Dr. John L. Todd, and Dr. Cuthbert Christy; with a Com- seems probable that the incubation period between the time parison of the Trypanosomes of Uganda and the Congo Free of the infection with trypanosoma Gambiense and the appear- State by Dr. H. Wolferstan Thomas and Dr. Stanley F. ance of the symptoms associated with human trypanosomiasis Linton, as well as a Note on Tsetse Flies, by Mr. E. E. may be so short as four weeks." Austen. The contents of the volume are largely devoted to Article No. VII., by Mr. Ernest E. Austen, is entitled subjects appertaining to tropical medicine and to trypanoso- " Supplementary Notes on the Tsetse Flies (Genus Glossina, miasis and sleeping sickness especially. Some of the papers Wiedemann)." Since Mr. Austen’s publication of a mono- have already appeared in medical journals but it is convenient graph of the tsetse flies in 1903, when seven species of to have the important observations made by the members of tsetse flies were recognised and described, an eighth species, the various expeditions sent out by the Liverpool School of glossina Decorsei, has been described by Dr Emile Brumpt Tropical Medicine brought together in one volume. from specimens recently obtained by Dr. Decorse on the The first articles-No. I., Human Trypanosomiasis on the River Shari and the shores of Lake Chad. This parasite has Congo, No. II., Human Trypanosomiasis and its Relation to already been described together with a detailed account ’Congo Sleeping Sickness, and No. III., the Congo Floor of the several species of the tsetse flies. Maggot-have been published in various journals and formed In articles Nos. VIII., IX., X., and XI., Dr. J. W. W. ’the subjects of papers at the British Medical Association Stephens contributes four articles to the January series of meeting at Oxford in July, 1904. Dr. Dutton, Dr. Todd, and 1905 : (a) A New Hasmogregarine in an African Toad; (b) Dr. Christy were engaged in elucidating and investigating Two Cases of Intestinal Myiasis ; (e) a Note on the Pathology the various points of trypanosomiasis as it affected human of Tropical "Swellings"; and (d) Non-flagellate Typhoid beings and their careful work is well known. Bacilli. The hasmogregarine was obtained from one of a In article No. IV. Dr. Christy discusses the cerebro-spinal batch of toads received from Sierra Leone in October, 1903. fluid in sleeping sickness (trypanosomiasis) and analyses the Although the description of the cyst and its polar masses of ’results of 104 lumbar punctures. The conclusions at which this recently observed parasite differs in some respects from he arrived were : (a) That in many cases of trypanosomiasis previously described hsemogregarines in amphibians and the trypanosomes never find their way into the cerebro-spinal reptiles, Dr. Stephens, owing to the similarities which it ,fluid and in those in which they do it is during a late stage bears to others, is inclined to defer proposing a name for of the disease ; (b) that the parasites come and go in the the gregarine which he describes. The larvm of the flies met fiuid ; (c) that they may appear in the blood without being with in the intestine of two children in Liverpool were found present in the fluid and vice 6M<% ; ; and (<%) that there is no by Dr. Stephens to belong to two species-viz., those of the ’relation between the commencement of fever and other musca corvina and the homalomyia canicularis. The - symptoms and the entrance of the parasites into the cerebro- patient, the subject of tropical swellings, went to Liverpool spinal fluid. from Degama, Southern Nigeria. He was the subject of Article No. V., by Dr. H. Wolferstan Thomas and Dr. peculiar swellings in the hands, the arms, the face, and the S. F. Linton, is devoted to a Comparison of the Animal feet which were of a fugitive character and seldom occurred Reactions of the Trypanosomes of Uganda and Congo in more than one place at a time. The leucocytic count Free State Sleeping Sickness with those of Trypanosoma (600 counted) gave large mononuclears, 1 ; small mono- ’Gambiense. This article, which was published in nuclears, 23; polynuclears, 26; and eosinophiles, 50. No THE LANCET of May 14th, 1904, gives a detailed account iilarias were found. The condition appears to differ from of the investigations which succeeded in showing that the that present in "Calabar swelling." trypanosomes found in (a) the cerebro-spinal fluid of cases of z, Article No. XII., by Mr. A. E. Shipley, F.R.S., gives an Uganda sleeping sickness, (b) the cerebro-spinal fluid of cases I account of a Human Parasite from Africa, the Cladorchis - of Congo Free State sleeping sickness, (c) the blood of cases Watsoni (Conyngham). The patient came from German of Uganda trypanosome fever, and (d) the blood of cases of West Africa and was one of a gang of freed slaves. He had - Congo Free State fever are all identical in animal reactions constant diarrhoea; the stools passed contained numerous and morphology with the trypanosoma Gambiense. They reddish-yellow, translucent, gelatinous, oval bodies. After further determined : (1) that there seems to be no acquired death the oval bodies were found in the contents of the immunity against infection; (2) that there is no trans- upper part of the small intestine and proved to consist of mission of immunity to offspring ; and (3) that an animal a trematode belonging to the family paramphistomidse which seems to have recovered may months later show (Fischoeder) and to the sub-family cladorchinae. Man parasites once more, apparently as the result of lowered would appear to be but an occasional host of the parasite, vitality. the normal host being in all probability some herbivorous Article No. VI., by Dr. Dutton, Dr. Todd, and Dr. Christy, animal. gives a detailed account of Two Cases of Trypanosomiasis in Article No. XIII., by Dr. Dutton, deals with the filaria of Europeans. One case was that of a woman, aged 35 years, the African swift-Cypelus affinis. In the lice infecting the who gave the history of being severely bitten by "river flies" feathers of this bird the embryo of filaria cypseli was found. in August, 1901. This was succeeded in six days by a severe In the bird parent fiariie were found and embryos were met fever which lasted for 25 days. This attack was succeeded with in the lymph passages. The louse serves as an inter- by a weekly fever which continued for three months. mediate host and the bird by picking off the lice from Each febrile attack lasted about five days. From January amongst its feathers in all probability reinfects itself. to April, 1902, the temperature ranged between 990 and Article No. XIV. by Mr. Benjamin Moore and Mr. Herbert 100&deg; F. and was never normal. On arriving in England E. Roaf, is an elaborate account of an Experimental Study in April, 1902, the temperature gradually fell to normal of the Physical Chemistry of Anaesthesia in Relationship to and twice between the date of arrival and August, 1903, its Causation. Mr. Moore and Mr. Roaf conclude that chloro- when she returned to the Congo, did febrile attacks occur. form forms an unstable chemical compound or physical Red patches of about the size of a half-crown and lasting aggregation with the proteids experimented with and that for three or four days appeared on the legs whilst in it is carried in the blood in such a state of combination. " England. She had stiff joints and an "inflamed throat" The oxygen-carrying power of haemoglobin is not interfered and the eyes were" inflamed." On returning to the Congo with in presence of chloroform. Article No. XV. by Mr. E. S. Edie, consists of a descrip- 1 The Thompson Yates and Johnston Laboratories Report, edited by tion of experiments on the Action of Chloroform on the Rubert Boyce and Charles S. Sherrington, with H. E. Annett, Benjamin Proteids of Serum and Solution of Moore, Ronald Ross, and E. W. Hope, assisted by W. B. Warrington, upon Heamoglobin. E. E. Glynn, J. W. W. Stephens, A. E. Shipley, J. E. Dutton, J. L. Article No. XVI. is devoted to an account of a Simple Todd, H. Wolferstan Thomas, H. E. Roaf, Cuthbert Christy, S. F. Method for the Preparation and Determination of Lecithin, Linton, and E. S. Edie. Pp. 205. With illustrations and plates. Mr. Roaf and Mr. Edie. Vol. VI. (New Series). Part I, January, 1905. Published for the by University Press of Liverpool by Williams and Norgate, 14, Henrietta- street, Covent Garden, London. Price 15s. net. 2 Brit. Med. Jour., August 20th, 1904..
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