Analytical Technology in Nutrition Analysis • Jose M
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Highly Potent Visnagin Derivatives Inhibit Cyp1 and Prevent Doxorubicin Cardiotoxicity
Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity Aarti Asnani, … , David E. Sosnovik, Randall T. Peterson JCI Insight. 2018;3(1):e96753. https://doi.org/10.1172/jci.insight.96753. Research Article Cardiology Oncology Anthracyclines such as doxorubicin are highly effective chemotherapy agents used to treat many common malignancies. However, their use is limited by cardiotoxicity. We previously identified visnagin as protecting against doxorubicin toxicity in cardiac but not tumor cells. In this study, we sought to develop more potent visnagin analogs in order to use these analogs as tools to clarify the mechanisms of visnagin-mediated cardioprotection. Structure-activity relationship studies were performed in a zebrafish model of doxorubicin cardiomyopathy. Movement of the 5-carbonyl to the 7 position and addition of short ester side chains led to development of visnagin analogs with 1,000-fold increased potency in zebrafish and 250-fold increased potency in mice. Using proteomics, we discovered that doxorubicin caused robust induction of Cytochrome P450 family 1 (CYP1) that was mitigated by visnagin and its potent analog 23. Treatment with structurally divergent CYP1 inhibitors, as well as knockdown of CYP1A, prevented doxorubicin cardiomyopathy in zebrafish. The identification of potent cardioprotective agents may facilitate the development of new therapeutic strategies for patients receiving cardiotoxic chemotherapy. Moreover, these studies support the idea that CYP1 is an important contributor to doxorubicin cardiotoxicity and suggest that modulation of this pathway could be beneficial in the clinical setting. Find the latest version: https://jci.me/96753/pdf RESEARCH ARTICLE Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity Aarti Asnani,1,2 Bahoui Zheng,1 Yan Liu,1 You Wang,1 Howard H. -
Study of the Carotenoid Composition in Membrillo, Guanabana Toreta, Jobo and Mamey Fruits
Fruits, 2015, vol. 70(3), p. 163-172 c Cirad / EDP Sciences 2015 DOI: 10.1051/fruits/2015009 Available online at: www.fruits-journal.org Original article Study of the carotenoid composition in membrillo, guanabana toreta, jobo and mamey fruits Daniele Giuffrida1,, Dania Menchaca2, Paola Dugo3,4,5, Paola Donato1, Francesco Cacciola1 and Enrique Murillo2 1 Università degli Studi di Messina, Dipartimento di Scienze dell’Ambiente, della Sicurezza, del Territorio, degli Alimenti e della Salute, Viale F. Stagno d’Alcontres 31, 98166, Messina, Italy 2 Departamento de Bioquimica, Facultad de Ciencias Naturales Exactas y Tecnologia, Universidad de Panama, Panama 3 Università degli Studi di Messina, Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Viale Annunziata, 98168, Messina, Italy 4 Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma, Italy 5 Chromaleont s.r.l. A start-up of the University of Messina, Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Italy Received 4 September 2014 – Accepted 29 January 2015 Abstract – Introduction. Many tropical fruits have great health potential due to the possible presence of bioac- tive phytochemicals. Natural food composition databases are very important sources of information relative to natural food biodiversity and nutritional properties. The objective of this study was to report for the first time on the native carotenoid composition of the fruit of four tropical species from Panama. Materials and methods. Fully mature fruit were collected in Panama and analyzed by HPLC-DAD-APCI-MS, after carotenoid extraction with acetone. Results and discussion. The carotenoid composition had never been previously reported for two of the investigated fruits, mem- brillo (Gustavia superba) and guanabana toreta (Annona purpurea). -
ZAPOTE the Popular Name Represents Many Diverse Edible Fruits of Guatemala
Sacred Animals and Exotic Tropical Plants monzón sofía photo: by Dr. Nicholas M. Hellmuth and Daniela Da’Costa Franco, FLAAR Reports ZAPOTE The popular name represents many diverse edible fruits of Guatemala ne of the tree fruits raised by the Most zapotes have a soft fruit inside and Maya long ago that is still enjoyed a “zapote brown” covering outside (except today is the zapote. Although for a few that have other external colors). It Othere are several fruits of the same name, the is typical for Spanish nomenclature of fruits popular nomenclature is pure chaos. Some of and flowers to be totally confusing. Zapote is the “zapote” fruits belong to the sapotaceae a vestige of the Nahuatl (Aztec) word tzapotl. family and all are native to Mesoamerica. The first plant on our list, Manilkara But other botanically unrelated fruits are also zapote, is commonly named chicozapote. called zapote/sapote; some are barely edible This is one of the most appreciated edible (such as the zapotón). There are probably species because of its commercial value. It even other zapote-named fruits that are not is distributed from the southeast of Mexico, all native to Mesoamerica. especially the Yucatán Peninsula into Belize 60 Dining ❬ ANTIGUA and the Petén area, where it is occasionally now collecting pertinent information related an abundant tree in the forest. The principal to the eating habits of Maya people, and all products of these trees are the fruit; the the plants they used and how they used them latex, which is used as the basis of natural for food. -
Synthesis and Biological Activities Of5h-Furo [3,2-G] [1] Benzopyran-5-One Derivatives
IndianJournalof Chemistry Vol. 37B, January1998, pp. 68 - 72 Synthesis and biological activities of5H-furo [3,2-g] [1] benzopyran-5-one derivatives JehanA A Miky& HammoudaH Sharar ChemistryDepartment,Facultyof Science(Girls) 'PharmacologyDepartment,Facultyof Medicine,Al-AzharUniversity,NasrCity,Cairo,Egypt Received30 September1996; accepted(revised)31 May 1997 The acetylation of 4-methoxy and 4,9-dimethoxy-7-methyl-5H-furo-[3,2-g] [1] benzopyran-c-one (visnagin and khellin) 1 a-b with acetic anhydride gives 3-acetyl-visnagin and khellin 2a-b which on reaction with cyanoacetamide, a-cyanothioacetamide, malononitriles or ethyl cyanoacetate yield furobenzopyranyl pyridone derivatives 3 a-h or the possible isomer 4 a-h. When 3-acetyl-visnagin or khellin is treated with bromine 6-(ro-bromoacetyl) visnagin or khellin 5 a-b is obtained. The latter compound on treatment with thiourea and amines forms the 2-substituted-4-(3-furobenzopyranyl) thiazole 6 a-b and 6-(ro-aminoacetyl) furochromone derivatives 8 a-g respectively. The 2-amino-4-(3- furobenzopyranyl) thiazole on condensation with aldehyde yields the iminosubstituted thiazole derivatives 7 a-e. Results of the biological effect of compounds la, 6b, 3a, 8a and 3d on blood pressure in experimental animals have been reported. Benzopyran derivatives are known to have wide were condensed with the appropriate aldehyde (i.e. variety of pharmacological activities!". This benzaldehyde, 4-chlorobenzaldehyde or p-N,N- prompted us to modify this ring and to explore new dimethylaminobenzaldehyde) iminosubstituted thi- activities associated with this nucleus. Herein we azole derivatives 7a-e were obtained (cf. Table I). report the synthesis and biological activity of Analytical and spectroscopic results for all the hitherto unknown derivatives of 3-acetyl-visnagin compounds were in conformity with the assigned and khellin. -
Visnagin—A New Protectant Against Doxorubicin Cardiotoxicity? Inhibition of Mitochondrial Malate Dehydrogenase 2 (MDH2) and Beyond
Editorial Page 1 of 5 Visnagin—a new protectant against doxorubicin cardiotoxicity? Inhibition of mitochondrial malate dehydrogenase 2 (MDH2) and beyond Lei Xi Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298-0204, USA Correspondence to: Lei Xi, MD, FAHA. Associate Professor, Division of Cardiology, Box 980204, Virginia Commonwealth University, 1101 East Marshall Street, Room 7-020C, Richmond, VA 23298-0204, USA. Email: [email protected]. Submitted Oct 08, 2015. Accepted for publication Oct 13, 2015. doi: 10.3978/j.issn.2305-5839.2015.10.43 View this article at: http://dx.doi.org/10.3978/j.issn.2305-5839.2015.10.43 Doxorubicin (DOX) is a broad-spectrum and potent with excessive ROS generation in mitochondria (12,13). anthracycline antibiotic that has been widely used since Due to the complex multi-factorial cellular and 1960s as a chemotherapeutic agent to treat a variety of molecular drivers underlying DOX cardiotoxicity, the human cancers (1). Despite its superior anti-cancer efficacy, optimal therapeutic approaches for protection against the clinical use of DOX is often limited by dose-dependent DOX cardiotoxicity have not yet been identified, despite cardiotoxicity, which may lead to irreversible dilated over 40 years of extensive research. Notably Herman et al. cardiomyopathy and congestive heart failure (2,3). Currently in 1972 first introduced bisdioxopiperazine compound as predominant theories for explaining DOX cardiotoxicity a cardioprotective agent against DOX cardiotoxicity (14). include the DOX-induced increase of oxidative stress in The subsequent research in this area led to identification cardiomyocytes (4), alteration of mitochondrial energetics of dexrazoxane, the only drug currently approved by the (5,6), and direct effect on DNA. -
University of Bradford Ethesis
Effect of nanoparticles on human cells from healthy individuals and patients with respiratory diseases. Item Type Thesis Authors Osman, Ilham F. Rights <a rel="license" href="http://creativecommons.org/licenses/ by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by- nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http:// creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>. Download date 23/09/2021 14:42:50 Link to Item http://hdl.handle.net/10454/4864 University of Bradford eThesis This thesis is hosted in Bradford Scholars – The University of Bradford Open Access repository. Visit the repository for full metadata or to contact the repository team © University of Bradford. This work is licenced for reuse under a Creative Commons Licence. EFFECT OF NANOPARTICLES ON HUMAN CELLS FROM HEALTHY INDIVIDUALS AND PATIENTS WITH RESPIRATORY DISEASES ILHAM F. OSMAN MBBS, Khartoum University (Sudan) MSC, Manchester University (UK) PhD UNIVERSITY OF BRADFORD 2010 i Abstract Ever increasing applications of nanomaterials (materials with one or more dimension less than 100 nm) has raised awareness of their potential genotoxicity. They have unique physico–chemical properties and so could have unpredictable effects. Zinc oxide (ZnO) and titanium dioxide (TiO 2) are widely used in a number of commercial products. There are published studies indicating that some forms of these compounds may be photo-clastogenic in mammalian cells. What has not been investigated before is the effect of nanoparticles from these compounds in human germ cells. -
Woody and Herbaceous Plants Native to Haiti for Use in Miami-Dade Landscapes1
Woody and Herbaceous Plants Native to Haiti For use in Miami-Dade Landscapes1 Haiti occupies the western one third of the island of Hispaniola with the Dominican Republic the remainder. Of all the islands within the Caribbean basin Hispaniola possesses the most varied flora after that of Cuba. The plants contained in this review have been recorded as native to Haiti, though some may now have been extirpated due in large part to severe deforestation. Less than 1.5% of the country’s original tree-cover remains. Haiti’s future is critically tied to re- forestation; loss of tree cover has been so profound that exotic fast growing trees, rather than native species, are being used to halt soil erosion and lessen the risk of mudslides. For more information concerning Haiti’s ecological plight consult references at the end of this document. For present purposes all of the trees listed below are native to Haiti, which is why non-natives such as mango (the most widely planted tree) and other important trees such as citrus, kassod tree (Senna siamea) and lead tree (Leucanea leucocephala) are not included. The latter two trees are among the fast growing species used for re-forestation. The Smithsonian National Museum of Natural History’s Flora of the West Indies was an invaluable tool in assessing the range of plants native to Haiti. Not surprisingly many of the listed trees and shrubs 1 John McLaughlin Ph.D. U.F./Miami-Dade County Extension Office, Homestead, FL 33030 Page | 1 are found in other parts of the Caribbean with some also native to South Florida. -
Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms
International Journal of Molecular Sciences Review Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms Mina Cheraghi Nirumand 1, Marziyeh Hajialyani 2, Roja Rahimi 3, Mohammad Hosein Farzaei 2,*, Stéphane Zingue 4,5 ID , Seyed Mohammad Nabavi 6 and Anupam Bishayee 7,* ID 1 Office of Persian Medicine, Ministry of Health and Medical Education, Tehran 1467664961, Iran; [email protected] 2 Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran; [email protected] 3 Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1416663361, Iran; [email protected] 4 Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, Maroua 55, Cameroon; [email protected] 5 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaounde 812, Cameroon 6 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran; [email protected] 7 Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA * Correspondence: [email protected] (M.H.F.); [email protected] or [email protected] (A.B.); Tel.: +98-831-427-6493 (M.H.F.); +1-305-760-7511 (A.B.) Received: 21 January 2018; Accepted: 25 February 2018; Published: 7 March 2018 Abstract: Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. -
Potential Health Benefits of Plant Food-Derived Bioactive Components
foods Review Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview Mrinal Samtiya 1 , Rotimi E. Aluko 2 , Tejpal Dhewa 1,* and José Manuel Moreno-Rojas 3,* 1 Department of Nutrition Biology, School of Interdisciplinary and Applied Sciences, Central University of Haryana, Mahendergarh, Haryana 123031, India; [email protected] 2 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; [email protected] 3 Department of Food Science and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Alameda del Obispo, Avda. Menéndez Pidal, SN, 14004 Córdoba, Spain * Correspondence: [email protected] (T.D.); [email protected] (J.M.M.-R.) Abstract: Plant foods are consumed worldwide due to their immense energy density and nutritive value. Their consumption has been following an increasing trend due to several metabolic disorders linked to non-vegetarian diets. In addition to their nutritive value, plant foods contain several bioactive constituents that have been shown to possess health-promoting properties. Plant-derived bioactive compounds, such as biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids, etc., have been reported to be beneficial for human health, for instance in cases of cancer, cardiovascular diseases, and diabetes, as well as for people with gut, immune function, and neurodegenerative disorders. Previous studies have reported that bioactive components possess antioxidative, anti-inflammatory, and immunomodulatory properties, in addition to improving intestinal barrier functioning etc., which contribute to their ability to mitigate the pathological impact of various human diseases. This review describes the bioactive components derived from fruit, Citation: Samtiya, M.; Aluko, R.E.; vegetables, cereals, and other plant sources with health promoting attributes, and the mechanisms Dhewa, T.; Moreno-Rojas, J.M. -
Perennial Edible Fruits of the Tropics: an and Taxonomists Throughout the World Who Have Left Inventory
United States Department of Agriculture Perennial Edible Fruits Agricultural Research Service of the Tropics Agriculture Handbook No. 642 An Inventory t Abstract Acknowledgments Martin, Franklin W., Carl W. Cannpbell, Ruth M. Puberté. We owe first thanks to the botanists, horticulturists 1987 Perennial Edible Fruits of the Tropics: An and taxonomists throughout the world who have left Inventory. U.S. Department of Agriculture, written records of the fruits they encountered. Agriculture Handbook No. 642, 252 p., illus. Second, we thank Richard A. Hamilton, who read and The edible fruits of the Tropics are nnany in number, criticized the major part of the manuscript. His help varied in form, and irregular in distribution. They can be was invaluable. categorized as major or minor. Only about 300 Tropical fruits can be considered great. These are outstanding We also thank the many individuals who read, criti- in one or more of the following: Size, beauty, flavor, and cized, or contributed to various parts of the book. In nutritional value. In contrast are the more than 3,000 alphabetical order, they are Susan Abraham (Indian fruits that can be considered minor, limited severely by fruits), Herbert Barrett (citrus fruits), Jose Calzada one or more defects, such as very small size, poor taste Benza (fruits of Peru), Clarkson (South African fruits), or appeal, limited adaptability, or limited distribution. William 0. Cooper (citrus fruits), Derek Cormack The major fruits are not all well known. Some excellent (arrangements for review in Africa), Milton de Albu- fruits which rival the commercialized greatest are still querque (Brazilian fruits), Enriquito D. -
Systematics and Biogeography of the Clusioid Clade (Malpighiales) Brad R
Eastern Kentucky University Encompass Biological Sciences Faculty and Staff Research Biological Sciences January 2011 Systematics and Biogeography of the Clusioid Clade (Malpighiales) Brad R. Ruhfel Eastern Kentucky University, [email protected] Follow this and additional works at: http://encompass.eku.edu/bio_fsresearch Part of the Plant Biology Commons Recommended Citation Ruhfel, Brad R., "Systematics and Biogeography of the Clusioid Clade (Malpighiales)" (2011). Biological Sciences Faculty and Staff Research. Paper 3. http://encompass.eku.edu/bio_fsresearch/3 This is brought to you for free and open access by the Biological Sciences at Encompass. It has been accepted for inclusion in Biological Sciences Faculty and Staff Research by an authorized administrator of Encompass. For more information, please contact [email protected]. HARVARD UNIVERSITY Graduate School of Arts and Sciences DISSERTATION ACCEPTANCE CERTIFICATE The undersigned, appointed by the Department of Organismic and Evolutionary Biology have examined a dissertation entitled Systematics and biogeography of the clusioid clade (Malpighiales) presented by Brad R. Ruhfel candidate for the degree of Doctor of Philosophy and hereby certify that it is worthy of acceptance. Signature Typed name: Prof. Charles C. Davis Signature ( ^^^M^ *-^£<& Typed name: Profy^ndrew I^4*ooll Signature / / l^'^ i •*" Typed name: Signature Typed name Signature ^ft/V ^VC^L • Typed name: Prof. Peter Sfe^cnS* Date: 29 April 2011 Systematics and biogeography of the clusioid clade (Malpighiales) A dissertation presented by Brad R. Ruhfel to The Department of Organismic and Evolutionary Biology in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the subject of Biology Harvard University Cambridge, Massachusetts May 2011 UMI Number: 3462126 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. -
The Contribution of Plant Genetic Resources to Health and Dietary Diversity
THEMATIC BACKGROUND STUDY The Contribution of Plant Genetic Resources to Health and Dietary Diversity Béatrice Mouillé, U. Ruth Charrondière and Barbara Burlingame Nutrition Assessment and Nutrient Requirements Group, Nutrition and Consumer Protection Division, FAO 2 Disclaimer The content of this document is entirely the responsibility of the authors, and does not necessarily represent the views of the Food and Agriculture Organization of the United Nations (FAO), or its Members. The designations employed and the presentation of material do not imply the expression of any opinion whatsoever on the part of FAO concerning legal or development status of any country, territory, city or area or of its authorities or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed by FAO in preference to others of a similar nature that are not mentioned. CONTENTS EXECUTIVE SUMMARY 5 1. EDIBLE PLANT GENETIC RESOURCES 7 1.1 State of crop diversity and edible plant genetic resources 7 1.2 Edible plant genetic resources in gardens 7 1.2.1 Home and school gardens 7 1.2.2 Botanic gardens 9 1.3 Edible genetic resources in forests 10 2. NUTRITION, BIODIVERSITY AND HEALTH 10 2.1 State of food systems 10 2.2 Strategies to prevent and alleviate malnutrition 11 2.2.1 Improving the nutritional value of crops 11 2.2.1.1 The traditional approach: breeding for nutritional improvements 11 2.2.1.2 The modern approach: genetic engineering for nutritional improvement 11 2.3 The contribution of biodiversity to balanced diet and health 12 2.3.1 The example of antioxidants 12 2.4 Enhancing the contribution of biodiversity to nutrition 12 3.