The Research Road We Make: Statistics for the Uninitiated
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SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
ORIGINAL CONTRIBUTION SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis Faisal Fecto, MD; Jianhua Yan, MD, PhD; S. Pavan Vemula; Erdong Liu, MD; Yi Yang, MS; Wenjie Chen, MD; Jian Guo Zheng, MD; Yong Shi, MD, PhD; Nailah Siddique, RN, MSN; Hasan Arrat, MD; Sandra Donkervoort, MS; Senda Ajroud-Driss, MD; Robert L. Sufit, MD; Scott L. Heller, MD; Han-Xiang Deng, MD, PhD; Teepu Siddique, MD Background: The SQSTM1 gene encodes p62, a major In silico analysis of variants was performed to predict al- pathologic protein involved in neurodegeneration. terations in p62 structure and function. Objective: To examine whether SQSTM1 mutations con- Results: We identified 10 novel SQSTM1 mutations (9 tribute to familial and sporadic amyotrophic lateral scle- heterozygous missense and 1 deletion) in 15 patients (6 rosis (ALS). with familial ALS and 9 with sporadic ALS). Predictive in silico analysis classified 8 of 9 missense variants as Design: Case-control study. pathogenic. Setting: Academic research. Conclusions: Using candidate gene identification based on prior biological knowledge and the functional pre- Patients: A cohort of 546 patients with familial diction of rare variants, we identified several novel (n=340) or sporadic (n=206) ALS seen at a major aca- SQSTM1 mutations in patients with ALS. Our findings demic referral center were screened for SQSTM1 muta- provide evidence of a direct genetic role for p62 in ALS tions. pathogenesis and suggest that regulation of protein deg- radation pathways may represent an important thera- Main Outcome Measures: We evaluated the distri- peutic target in motor neuron degeneration. bution of missense, deletion, silent, and intronic vari- ants in SQSTM1 among our cohort of patients with ALS. -
Filesystems HOWTO Filesystems HOWTO Table of Contents Filesystems HOWTO
Filesystems HOWTO Filesystems HOWTO Table of Contents Filesystems HOWTO..........................................................................................................................................1 Martin Hinner < [email protected]>, http://martin.hinner.info............................................................1 1. Introduction..........................................................................................................................................1 2. Volumes...............................................................................................................................................1 3. DOS FAT 12/16/32, VFAT.................................................................................................................2 4. High Performance FileSystem (HPFS)................................................................................................2 5. New Technology FileSystem (NTFS).................................................................................................2 6. Extended filesystems (Ext, Ext2, Ext3)...............................................................................................2 7. Macintosh Hierarchical Filesystem − HFS..........................................................................................3 8. ISO 9660 − CD−ROM filesystem.......................................................................................................3 9. Other filesystems.................................................................................................................................3 -
Archives of Agriculture and Environmental Science
ISSN (Online) : 2456-6632 Archives of Agriculture and Environmental Science An International Journal Volume 4 | Issue 2 Agriculture and Environmental Science Academy www.aesacademy.org Scan to view it on the web Archives of Agriculture and Environmental Science (Abbreviation: Arch. Agr. Environ. Sci.) ISSN: 2456-6632 (Online) An International Research Journal of Agriculture and Environmental Sciences Volume 4 Number 2 2019 Abstracted/Indexed: The journal AAES is proud to be a registered member of the following leading abstracting/indexing agencies: Google Scholar, AGRIS-FAO, CrossRef, Informatics, jGate @ e-Shodh Sindhu, WorldCat Library, OpenAIRE, Zenodo ResearchShare, DataCite, Index Copernicus International, Root Indexing, Research Gate etc. All Rights Reserved © 2016-2019 Agriculture and Environmental Science Academy Disclaimer: No part of this booklet may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission of the publisher. However, all the articles published in this issue are open access articles which are distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited For information regarding permission, write us [email protected]. An official publication of Agriculture and Environmental Science Academy 86, Gurubaksh Vihar (East) Kankhal Haridwar-249408 (Uttarakhand), India Website: https://www.aesacademy.org Email: [email protected] Phone: +91-98971-89197 Archives of Agriculture and Environmental Science (An International Research Journal) (Abbreviation: Arch. Agri. Environ. Sci.) Aims & Objectives: The journal is an official publication of Agriculture and Environmental Science Academy. -
Strategies for Non-Invasive Management of High-Grade Cervical Intraepithelial Neoplasia
Strategies for non-invasive management of high-grade cervical intraepithelial neoplasia Citation for published version (APA): Koeneman, M. M. (2019). Strategies for non-invasive management of high-grade cervical intraepithelial neoplasia: prognostic biomarkers and immunotherapy. Maastricht University. https://doi.org/10.26481/dis.20190116mk Document status and date: Published: 01/01/2019 DOI: 10.26481/dis.20190116mk Document Version: Publisher's PDF, also known as Version of record Please check the document version of this publication: • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. -
Latexsample-Thesis
INTEGRAL ESTIMATION IN QUANTUM PHYSICS by Jane Doe A dissertation submitted to the faculty of The University of Utah in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Mathematics The University of Utah May 2016 Copyright c Jane Doe 2016 All Rights Reserved The University of Utah Graduate School STATEMENT OF DISSERTATION APPROVAL The dissertation of Jane Doe has been approved by the following supervisory committee members: Cornelius L´anczos , Chair(s) 17 Feb 2016 Date Approved Hans Bethe , Member 17 Feb 2016 Date Approved Niels Bohr , Member 17 Feb 2016 Date Approved Max Born , Member 17 Feb 2016 Date Approved Paul A. M. Dirac , Member 17 Feb 2016 Date Approved by Petrus Marcus Aurelius Featherstone-Hough , Chair/Dean of the Department/College/School of Mathematics and by Alice B. Toklas , Dean of The Graduate School. ABSTRACT Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. -
Mathematics of the Gateway Arch Page 220
ISSN 0002-9920 Notices of the American Mathematical Society ABCD springer.com Highlights in Springer’s eBook of the American Mathematical Society Collection February 2010 Volume 57, Number 2 An Invitation to Cauchy-Riemann NEW 4TH NEW NEW EDITION and Sub-Riemannian Geometries 2010. XIX, 294 p. 25 illus. 4th ed. 2010. VIII, 274 p. 250 2010. XII, 475 p. 79 illus., 76 in 2010. XII, 376 p. 8 illus. (Copernicus) Dustjacket illus., 6 in color. Hardcover color. (Undergraduate Texts in (Problem Books in Mathematics) page 208 ISBN 978-1-84882-538-3 ISBN 978-3-642-00855-9 Mathematics) Hardcover Hardcover $27.50 $49.95 ISBN 978-1-4419-1620-4 ISBN 978-0-387-87861-4 $69.95 $69.95 Mathematics of the Gateway Arch page 220 Model Theory and Complex Geometry 2ND page 230 JOURNAL JOURNAL EDITION NEW 2nd ed. 1993. Corr. 3rd printing 2010. XVIII, 326 p. 49 illus. ISSN 1139-1138 (print version) ISSN 0019-5588 (print version) St. Paul Meeting 2010. XVI, 528 p. (Springer Series (Universitext) Softcover ISSN 1988-2807 (electronic Journal No. 13226 in Computational Mathematics, ISBN 978-0-387-09638-4 version) page 315 Volume 8) Softcover $59.95 Journal No. 13163 ISBN 978-3-642-05163-0 Volume 57, Number 2, Pages 201–328, February 2010 $79.95 Albuquerque Meeting page 318 For access check with your librarian Easy Ways to Order for the Americas Write: Springer Order Department, PO Box 2485, Secaucus, NJ 07096-2485, USA Call: (toll free) 1-800-SPRINGER Fax: 1-201-348-4505 Email: [email protected] or for outside the Americas Write: Springer Customer Service Center GmbH, Haberstrasse 7, 69126 Heidelberg, Germany Call: +49 (0) 6221-345-4301 Fax : +49 (0) 6221-345-4229 Email: [email protected] Prices are subject to change without notice. -
Using History to Teach Computer Science and Related Disciplines
Computing Research Association Using History T o T eachComputer Science and Related Disciplines Using History To Teach Computer Science and Related Disciplines Edited by Atsushi Akera 1100 17th Street, NW, Suite 507 Rensselaer Polytechnic Institute Washington, DC 20036-4632 E-mail: [email protected] William Aspray Tel: 202-234-2111 Indiana University—Bloomington Fax: 202-667-1066 URL: http://www.cra.org The workshops and this report were made possible by the generous support of the Computer and Information Science and Engineering Directorate of the National Science Foundation (Award DUE- 0111938, Principal Investigator William Aspray). Requests for copies can be made by e-mailing [email protected]. Copyright 2004 by the Computing Research Association. Permission is granted to reproduce the con- tents, provided that such reproduction is not for profit and credit is given to the source. Table of Contents I. Introduction ………………………………………………………………………………. 1 1. Using History to Teach Computer Science and Related Disciplines ............................ 1 William Aspray and Atsushi Akera 2. The History of Computing: An Introduction for the Computer Scientist ……………….. 5 Thomas Haigh II. Curricular Issues and Strategies …………………………………………………… 27 3. The Challenge of Introducing History into a Computer Science Curriculum ………... 27 Paul E. Ceruzzi 4. History in the Computer Science Curriculum …………………………………………… 33 J.A.N. Lee 5. Using History in a Social Informatics Curriculum ....................................................... 39 William Aspray 6. Introducing Humanistic Content to Information Technology Students ……………….. 61 Atsushi Akera and Kim Fortun 7. The Synergy between Mathematical History and Education …………………………. 85 Thomas Drucker 8. Computing for the Humanities and Social Sciences …………………………………... 89 Nathan L. Ensmenger III. Specific Courses and Syllabi ………………………………………....................... 95 Course Descriptions & Syllabi 9. -
Integral Estimation in Quantum Physics
INTEGRAL ESTIMATION IN QUANTUM PHYSICS by Jane Doe A dissertation submitted to the faculty of The University of Utah in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Mathematical Physics Department of Mathematics The University of Utah May 2016 Copyright c Jane Doe 2016 All Rights Reserved The University of Utah Graduate School STATEMENT OF DISSERTATION APPROVAL The dissertation of Jane Doe has been approved by the following supervisory committee members: Cornelius L´anczos , Chair(s) 17 Feb 2016 Date Approved Hans Bethe , Member 17 Feb 2016 Date Approved Niels Bohr , Member 17 Feb 2016 Date Approved Max Born , Member 17 Feb 2016 Date Approved Paul A. M. Dirac , Member 17 Feb 2016 Date Approved by Petrus Marcus Aurelius Featherstone-Hough , Chair/Dean of the Department/College/School of Mathematics and by Alice B. Toklas , Dean of The Graduate School. ABSTRACT Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. Blah blah blah blah blah blah blah blah blah blah blah blah blah blah blah. -
Software in the Scientific Literature: Problems with Seeing, Finding, And
Software in the Scientific Literature: Problems with Seeing, Finding, and Using Software Mentioned in the Biology Literature James Howison School of Information, University of Texas at Austin, 1616 Guadalupe Street, Austin, TX 78701, USA. E-mail: [email protected] Julia Bullard School of Information, University of Texas at Austin, 1616 Guadalupe Street, Austin, TX 78701, USA. E-mail: [email protected] Software is increasingly crucial to scholarship, yet the incorporates key scientific methods; increasingly, software visibility and usefulness of software in the scientific is also key to work in humanities and the arts, indeed to work record are in question. Just as with data, the visibility of with data of all kinds (Borgman, Wallis, & Mayernik, 2012). software in publications is related to incentives to share software in reusable ways, and so promote efficient Yet, the visibility of software in the scientific record is in science. In this article, we examine software in publica- question, leading to concerns, expressed in a series of tions through content analysis of a random sample of 90 National Science Foundation (NSF)- and National Institutes biology articles. We develop a coding scheme to identify of Health–funded workshops, about the extent that scientists software “mentions” and classify them according to can understand and build upon existing scholarship (e.g., their characteristics and ability to realize the functions of citations. Overall, we find diverse and problematic Katz et al., 2014; Stewart, Almes, & Wheeler, 2010). In practices: Only between 31% and 43% of mentions particular, the questionable visibility of software is linked to involve formal citations; informal mentions are very concerns that the software underlying science is of question- common, even in high impact factor journals and across able quality. -
Assessment of the Impact of the Electronic Submission and Review Environment on the Efficiency and Effectiveness of the Review of Human Drugs – Final Report
Evaluations and Studies of New Drug Review Programs Under PDUFA IV for the FDA Contract No. HHSF223201010017B Task No. 2 Assessment of the Impact of the Electronic Submission and Review Environment on the Efficiency and Effectiveness of the Review of Human Drugs – Final Report September 9, 2011 Booz | Allen | Hamilton Assessment of the Impact of the Electronic Submission and Review Environment Final Report Table of Contents EXECUTIVE SUMMARY .............................................................................................................. 1 Assessment Overview .......................................................................................................... 1 Degree of Electronic Implementation ................................................................................... 1 Baseline Review Performance ............................................................................................. 2 Exchange and Content Data Standards ............................................................................... 4 Review Tools and Training Analysis .................................................................................... 5 Current Organization and Responsibilities ........................................................................... 6 Progress against Ideal Electronic Review Environment ....................................................... 6 Recommendations ............................................................................................................... 8 ASSESSMENT OVERVIEW ........................................................................................................ -
Analyzing Data with Graphpad Prism
Analyzing Data with GraphPad Prism A companion to GraphPad Prism version 3 Harvey Motulsky President GraphPad Software Inc. [email protected] GraphPad Software, Inc. © 1999 GraphPad Software, Inc. All rights reserved. All Rights Reserved. GraphPad Prism, Prism and InStat are registered trademarks of GraphPad Contents Software, Inc. GraphPad is a trademark of GraphPad Software, Inc. Use of the software is subject to the restrictions contained in the Preface.........................................................................................................2 accompanying software license agreement. Introduction to statistical comparisons..........................................................3 Garbage in, garbage out ...................................................................................3 Citation: H.J. Motulsky, Analyzing Data with GraphPad Prism, 1999, When do you need statistical calculations? ........................................................3 The key concept: Sampling from a population....................................................4 GraphPad Software Inc., San Diego CA, www.graphpad.com. Confidence intervals ........................................................................................8 P values ..........................................................................................................9 Hypothesis testing and statistical significance................................................... 11 Acknowledgements: The following individuals made substantial Statistical power ........................................................................................... -
Release Notes for Fedora 17
Fedora 17 Release Notes Release Notes for Fedora 17 Edited by The Fedora Docs Team Copyright © 2012 Fedora Project Contributors. The text of and illustrations in this document are licensed by Red Hat under a Creative Commons Attribution–Share Alike 3.0 Unported license ("CC-BY-SA"). An explanation of CC-BY-SA is available at http://creativecommons.org/licenses/by-sa/3.0/. The original authors of this document, and Red Hat, designate the Fedora Project as the "Attribution Party" for purposes of CC-BY-SA. In accordance with CC-BY-SA, if you distribute this document or an adaptation of it, you must provide the URL for the original version. Red Hat, as the licensor of this document, waives the right to enforce, and agrees not to assert, Section 4d of CC-BY-SA to the fullest extent permitted by applicable law. Red Hat, Red Hat Enterprise Linux, the Shadowman logo, JBoss, MetaMatrix, Fedora, the Infinity Logo, and RHCE are trademarks of Red Hat, Inc., registered in the United States and other countries. For guidelines on the permitted uses of the Fedora trademarks, refer to https:// fedoraproject.org/wiki/Legal:Trademark_guidelines. Linux® is the registered trademark of Linus Torvalds in the United States and other countries. Java® is a registered trademark of Oracle and/or its affiliates. XFS® is a trademark of Silicon Graphics International Corp. or its subsidiaries in the United States and/or other countries. MySQL® is a registered trademark of MySQL AB in the United States, the European Union and other countries. All other trademarks are the property of their respective owners.